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Allergic rhinitis and combined therapy

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https://www.readbyqxmd.com/read/27882840/a-comparison-of-health-care-resource-utilization-and-costs-for-patients-with-allergic-rhinitis-on-single-product-or-free-combination-therapy-of-intranasal-steroids-and-intranasal-antihistamines
#1
Brooke Harrow, Ahmad R Sedaghat, Amanda Caldwell-Tarr, Robert Dufour
BACKGROUND: Allergic rhinitis (AR) is a common condition that can be treated with a number of different therapies. Treatments such as intranasal antihistamines (INAs) and intranasal steroids (INSs) are widely used by AR patients. For some allergy sufferers, a combination of therapies, specifically an INA and an INS, is required to address their symptoms. A new treatment, the formulation of azelastine hydrochloride and fluticasone pro-pionate used as a single spray (MP-AzeFlu), has become available for AR patients who need both types of treatment...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27872863/attention-deficit-disorder-and-allergic-rhinitis-are-they-related
#2
Isaac Melamed, Melinda Heffron
The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effective in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed with comorbid ADHD and allergy using cetirizine (n = 12), sustained-release methylphenidate (n = 12), or cetirizine + methylphenidate (n = 14)...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27608474/probiotics-and-refractory-chronic-spontaneous-urticaria
#3
E Nettis, E Di Leo, A Pastore, M Distaso, I Zaza, M Vacca, L Macchia, A Vacca
Background. In chronic spontaneous urticaria (CSU) first-line therapy with an antihistamine-based regimen may not achieve satisfactory control in patients. Thus, a continuing need exists for effective and safe treatments for refractory CSU. Aim. To evaluate the clinical efficacy and safety of an intake of a combination of 2 probiotics (Lactobacillus salivarius LS01 and Bifidobacterium breve BR03) in patients with CSU who remain symptomatic despite concomitant H1-antihistamine therapy. Methods. This report analyzes the effects of therapy with two probiotic strains on the clinical progress of 52 unselected patients with difficulty to treat CSU underwent to medical examination in two Italian specialist urticaria Clinics between September 2013 and September 2014...
September 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27532316/the-effectiveness-of-ayurvedic-oil-based-nasal-instillation-nasya-medicines-in-the-treatment-of-facial-paralysis-ardita-a-systematic-review
#4
Manuel Joseph Vivera, Judith Streak Gomersall
BACKGROUND: Ardita (facial paralysis) is a medical condition that disfigures or distorts the facial appearance of the sufferer causing facial asymmetry and malfunction. Ardita patients may benefit from considering alternative treatments such as Ayurveda, including Taila Nasya (nasal instillation of medicated oil). OBJECTIVES: To synthesize the best available evidence on the effectiveness of different Nasya oils in the treatment of Ardita. INCLUSION CRITERIA TYPES OF PARTICIPANTS: Studies conducted on adult sufferers (18-70 years) of Ardita (chronic or acute) in any setting were considered...
April 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27522261/the-efficacy-and-safety-of-h1-antihistamine-versus-montelukast-for-allergic-rhinitis-a-systematic-review-and-meta-analysis
#5
Chunhui Wei
PURPOSE: In order to verify the differences of effectiveness and safety between SAHs and Montelukast, and to find out potential uncared-for problems, we performed a systematic review and Meta-analysis to proceed a qualitative describe and quantitative assessment. METHODS: We searched the databases of Pubmed, the Cochrane Library, Nature and Science as well as Wanfang data and CNKI from 2000 to March 2016, using key words "Montelukast SAH" or "H1-antihistamine Montelukast", or "Loratadine Montelukast", or "Desloratadine Montelukast", or "Levocetirizine Montelukast", or "Cetirizen Montelukast", or "Fexofenadine Montelukast"...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27508135/comparative-study-of-apo-cetirizine-single-therapy-and-intermittent-sequential-therapy-with-cetirizine-loratadine-and-chlorpheniramine-in-allergic-rhinitis
#6
Ali Safavi Naini, Jahangir Ghorbani, Ebrahim Mazloom
There are limited numbers of articles, studying combined use of antihistamines. In this study, we compare single therapy of Apo-Cetirizine with a new regimen of intermittent sequential therapy with cetirizine, loratadine and chlorpheniramine in treatment of seasonal allergic rhinitis. This randomized clinical trial was performed between April and September at the peak prevalence of seasonal allergic rhinitis. Fifty-four eligible patients diagnosed clinically to have seasonal allergic rhinitis were randomized in two groups: 24 cases in single therapy arm, received Apo-Cetirizine 10 mg tablet daily and in other arm, 30 patients received sequential regimen of cetirizine 10 mg tablet, loratadine 10 mg tablet and chlorpheniramine 4 mg tablet, one tablet each day...
September 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27466026/role-of-antioxidants-on-the-clinical-outcome-of-patients-with-perennial-allergic-rhinitis
#7
B Chauhan, M Gupta, K Chauhan
BACKGROUND: Antioxidants have a preventive or therapeutic role in oxygen free radical-mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis. METHODS: Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks...
July 26, 2016: Allergy & Rhinology
https://www.readbyqxmd.com/read/27328556/clinical-question-nasal-saline-or-intranasal-corticosteroids-to-treat-allergic-rhinitis-in-children
#8
REVIEW
Stefani Madison, Elizabeth Aubrey Brown, Rachel Franklin, Elizabeth A Wickersham, Laine H McCarthy
CLINICAL QUESTION: In pediatric populations, is nasal saline irrigation as effective as intranasal corticosteroids at relieving allergic rhinitis symptoms? ANSWER: No. Intranasal steroids are more effective than nasal saline alone to reduce symptoms of allergic rhinitis (AR) in children. Combination therapy further improves symptom reduction. LEVEL OF EVIDENCE FOR THE ANSWER: B SEARCH TERMS: Allergic Rhinitis, Nasal Saline, Nasal corticosteroids, children younger than age 18...
April 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/27320298/case-of-suspected-sialodochitis-fibrinosa-kussmaul-s-disease
#9
Kamichika Hayashi, Takeshi Onda, Hitoshi Ohata, Nobuo Takano, Takahiko Shibahara
Here we report a case of Kussmaul's disease, or sialodochitis fibrinosa. This rare disease is characterized by recurrent swelling of the salivary glands, which then discharge clots of fibrin into the oral cavity. An 80-year-old man with a history of allergic rhinitis visited our department with the chief complaint of pain in the bilateral parotid gland area on eating. An initial examination revealed mild swelling and tenderness in this region, and indurations could be felt around the bilateral parotid papillae...
2016: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/27302143/effect-of-sodium-hyluronate-added-to-topical-corticosteroids-in-chronic-rhinosinusitis-with-nasal-polyposis
#10
E Cantone, M Iengo
BACKGROUND: Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis...
June 2, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/27276875/characteristics-of-traditional-chinese-medicine-users-and-prescription-analysis-for-pediatric-atopic-dermatitis-a-population-based-study
#11
Yu-Chun Chen, Yi-Hsuan Lin, Sindy Hu, Hsing-Yu Chen
BACKGROUND: Atopic dermatitis among children is an important issue due to relapses and skin manifestations. Traditional Chinese medicine (TCM) is commonly used to treat children with atopic dermatitis. The aim of this study was to investigate the characteristics and TCM prescriptions of patients with atopic dermatitis using a nationwide database. METHODS: Children younger than 12 years of age diagnosed with atopic dermatitis, defined as ICD-9-CM codes 691.8 and 692...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27213663/-the-modern-strategies-for-the-treatment-of-allergic-rhinitis
#12
REVIEW
E V Nosulya, I A Kim
The present literature review had the objective to analyze the published data concerning the effectiveness of intranasal administration of antihistamine preparations and intranasal glucocorticoids for the treatment of allergic rhinitis. Special emphasis is placed on the clinical significance and the further prospects for the application of a fixed combination of these medications including azelastineplusmometasonefuroateas the first choice therapy of moderately severe and severe manifestations of allergic rhinitis...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27058241/factors-affecting-ability-to-achieve-asthma-control-in-adult-patients-with-moderate-to-severe-persistent-asthma
#13
Lyne Scott, Marilyn Li, Salima Thobani, Breck Nichols, Tricia Morphew, Kenny Yat-Choi Kwong
OBJECTIVE: Despite the use of optimal therapy and guidelines, the rate of asthma control is suboptimal in adult populations. Purpose of this study is to describe factors associated with ability to achieve well-controlled asthma over time for adult patients treated in a tertiary medical center-based asthma outpatient specialty clinic. METHODS: Existing clinical data collected for 320 adult patients enrolled in a hospital-based outpatient asthma specialty clinic from July 1, 2003 through June 30, 2011 evaluated time to achieve well-controlled asthma and factors associated with well-controlled asthma such as adherence and lack of previous exacerbations...
August 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27057098/altered-expression-of-ifn-%C3%AE-2-in-allergic-airway-disorders-and-identification-of-its-cell-origins
#14
Qiuli Wang, Dong Chen, Hua Xie, Xiaoping Lin, Xuefeng Wang, Qijian Yao, Xiaoxuan Zheng, Chiyan Xu, Lingfei Chen, Shaoheng He, Huiyun Zhang
This study investigated the expression levels of interferon- (IFN-) λ2 in peripheral blood and tissues. The results showed that the levels of IFN-λ2 were elevated by 17.9% and 14.2% in the plasma of allergic rhinitis (AR) and combined rhinitis with asthma (AR + AS), which was positively correlated with the level of tryptase but negatively correlated with the level of IL-10. IFN-λ2 was predominately expressed in the CD16+ cells and CD14+ cells in healthy control subjects (HC) but upregulated only in CD8+ cells of AR and in eosinophils of asthma...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/26932169/the-clinical-effect-of-vitamin-d-supplementation-combined-with-grass-specific-sublingual-immunotherapy-in-children-with-allergic-rhinitis
#15
Joanna Jerzynska, Wlodzimierz Stelmach, Blażej Rychlik, Joanna Lechańska, Daniela Podlecka, Iwona Stelmach
BACKGROUND: An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy. OBJECTIVE: To compare the clinical efficacy of SLIT with vitamin D supplementation with placebo in children with allergic rhinitis. Secondary end points included lung function, exhaled nitric oxide concentration, methacholine bronchial provocation test, and serum level of calcifediol (25[OH]D). METHODS: Fifty children, ages 5-12 years, sensitive to grass pollen, with allergic rhinitis (eight patients had concomitant asthma) participated in a 5-month prospective, randomized, double-blind, placebo-controlled trial...
March 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/26867532/correlation-of-skin-test-results-and-specific-immunoglobulin-e-blood-levels-with-nasal-provocation-testing-for-house-dust-mite-allergies
#16
Boris R Haxel, Tilman Huppertz, Patrick Boessert, Florian Bast, Kai Fruth
BACKGROUND: Allergen-specific immunotherapy for house-dust mite (HDM) allergies is associated with lower success rates when compared with similar treatments for other inhalant allergens, such as grass or birch. One reason might be the greater difficulty in diagnosing patients with assumed HDM allergies because symptoms occur perennially and may differ from those of a conventional allergic rhinitis. OBJECTIVE: The aim of the study was to compare the different methods of diagnosis in patients with assumed HDM allergy...
January 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/26800187/recent-pharmacological-developments-in-the-treatment-of-perennial-and-persistent-allergic-rhinitis
#17
REVIEW
Ludger Klimek, Joaquim Mullol, Peter Hellings, Philippe Gevaert, Ralph Mösges, Wytske Fokkens
INTRODUCTION: Allergic rhinitis (AR) has a major negative impact on patients' quality of life (QoL) and carries a high socio economic burden. This is particularly the case for patients who experience symptoms for extended periods of time (i.e. those with perennial (PAR) or persistent AR (PER), depending on the classification system used). This review covers available pharmacological advances and recent developments in the treatment of PAR or PER. AREAS COVERED: Pharmacological AR treatment is used to reduce symptom burden and help restore patients' normal daily routine...
2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/26733401/emerging-drugs-for-the-treatment-of-perennial-allergic-rhinitis
#18
Amelia Licari, Riccardo Castagnoli, Chiara Bottino, Alessia Marseglia, GianLuigi Marseglia, Giorgio Ciprandi
INTRODUCTION: Allergic rhinitis is a worldwide health problem, currently affecting up to 40% of the general population, and characterized by the following symptoms in a variable degree of severity and duration: nasal congestion/obstruction, rhinorrhea, itchy nose and/or eyes, and/or sneezing. General symptoms like fatigue, reduced quality of sleep, impaired concentration and reduced productivity, if left untreated, may significantly affect quality of life. In addition, of being associated to various comorbidities, allergic rhinitis is also an independent risk factor for the development and worsening of asthma...
2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/26581315/recent-patents-of-complementary-and-alternative-medicine-for-allergic-rhinitis
#19
Kam L Hon, Ching K Fung, Alexander K C Leung, Hung S Lam, So L Lee
Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/ nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate pharmacotherapy...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/26545381/concomitant-corticosteroid-nasal-spray-plus-antihistamine-oral-or-local-spray-for-the-symptomatic-management-of-allergic-rhinitis
#20
Shaoyan Feng, Yunping Fan, Zibin Liang, Renqiang Ma, Wanwei Cao
The purpose of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to compare the symptomatic management of corticosteroid nasal spray plus antihistamine (oral or local spray) with that of either therapy given alone, or placebo in patients with allergic rhinitis (AR). The PRISMA guidelines for meta-analysis reporting were followed. Total nasal symptom scores and individual nasal symptom scores were pooled after assessing heterogeneity among studies. The pooled estimates were expressed as weighted mean differences (WMD) between treatments...
November 2016: European Archives of Oto-rhino-laryngology
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