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Cutaneous pathology

A-K-G Gonzaga, D-H-I-P de Oliveira, M-L-D-S Lopes, T-J-S Filho, L-M-G Queiroz, É-J-D da Silveira
BACKGROUND: Oral focal mucinosis (OFM) is a rare soft tissue lesion of unknown etiology that exhibits tumor-like growth. It is considered the oral counterpart of cutaneous focal mucinosis or cutaneous myxoid cyst. This is a retrospective study of oral OFM diagnosed over a period of 42 years at an oral pathology service. MATERIAL AND METHODS: Clinical, histopathological and immunohistochemical data were analyzed. Alcian blue staining and S-100 immunohistochemistry were performed...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
M van der Linden, M S Schuurman, J Bulten, L F A G Massuger, J IntHout, M A van der Aa, J A de Hullu
BACKGROUND: Vulvar Paget disease (VPD) is extremely rare and thought to be associated with other malignancies. OBJECTIVE: The aim of this study was to evaluate the risk of developing breast, intestinal, and urological malignancies in patients with VPD compared with the general population, and in particular focus on the risk of malignancy in patients with cutaneous non-invasive VPD. METHODS: Data on the oncologic history of patients with any type of VPD between 2000 and 2015 were obtained from PALGA, a nationwide archive containing all pathology reports in the Netherlands...
June 19, 2018: British Journal of Dermatology
Yidan Zhang, Xiujun Zhang, Shanshan Fan, Lili Song, Zhen Yang, Pengwei Zhuang, Yanjun Zhang
Cutaneous eruption is a common drug-adverse reaction, characterised by keratinocytes inflammation and apoptosis. Shuanghuanglian injeciton (SHLI) is a typical Chinese medicine injection, which is used to treat influenza. It has been reported that SHLI has the potential to induce cutaneous adverse eruptions. However, the mechanisms remain unclear. Since desmoglein 1 (DSG1) shows a crucial role in maintaining skin barrier function and cell susceptibility, we assume that DSG1 plays a critical role in the cutaneous eruptions induced by SHLI...
June 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Arpan Tahim, Sarah Ali, Leo Cheng
INTRODUCTION: The aim of surgical management of benign facial skin lumps is to remove the lesion in its entirety, with minimal damage to adjacent tissue structures, while maintaining facial aesthetics. A method to achieve these goals is to remove peri-oral lesions in the labial and buccal zones via an intra-oral approach. We report an extended cases series of facial skin lumps that were excised using an intra-oral approach. METHODS: A retrospective analysis was performed on all patients who underwent excisions of benign cutaneous lesions on the face via an intra-oral approach...
June 16, 2018: Oral and Maxillofacial Surgery
Neelam A Vashi, Nicole Patzelt, Stephen Wirya, Mayra B C Maymone, Pedro Zancanaro, Roopal V Kundu
With globalization and widespread immigration, physicians increasingly encounter patients from varying backgrounds and diverse customs. Although certain cultural practices are widely performed, there is limited medical literature describing their dermatologic and systemic effects and complications. Population diversity and sharing of traditions make it increasingly important for dermatologists to understand the role of cultural practices and recognize physiologic and pathologic sequelae. In addition, dermatologists are often adjured to assess skin findings that may be mistaken for abuse...
July 2018: Journal of the American Academy of Dermatology
Alejandra Jaque, Alexandra Mereniuk, Shachar Sade, Perla Lansang, Kevin Imrie, Neil H Shear
Eosinophilia, both peripheral and in cutaneous tissue, is not a typical finding in mycosis fungoides; in fact, when faced with a lymphoeosinophilic infiltrate, mycosis fungoides is often not part of initial differential considerations. However, eosinophilia has been described in certain subtypes of mycosis fungoides, namely, in folliculotropic mycosis fungoides. We describe three challenging cases of folliculotropic mycosis fungoides presenting with varied clinical morphologies and a dense lymphoeosinophilic infiltrate and/or severe hypereosinophilia that obscured the final diagnosis for years...
2018: SAGE Open Medical Case Reports
Catarina Faria, Ana Antunes, Henedina Antunes, Susana Carvalho
Herpes zoster, caused by varicella zoster virus (VZV) reactivation, affects mainly the adult population, although it can occur in children. This happens when primary infection (varicella) has occurred at a very young age or in immunocompromised patients. Complications are rare in healthy individuals. They include VZV cutaneous dissemination, which affects 2%-10% of immunocompromised patients.We present a previously healthy child, with history of varicella during her first month of life, which presented at age 8 with a severe case of herpes zoster, complicated with cutaneous dissemination...
June 12, 2018: BMJ Case Reports
Priya Govindaraju, Leslie Todd, Snehal Shetye, James Monslow, Ellen Puré
Cutaneous wound healing consists of three main phases: inflammation, re-epithelialization, and tissue remodeling. During normal wound healing, these processes are tightly regulated to allow restoration of skin function and biomechanics. In many instances, healing leads to an excess accumulation of fibrillar collagen (the principal protein found in the extracellular matrix - ECM), and the formation of scar tissue, which has compromised biomechanics, tested using ramp to failure tests, compared to normal skin (Corr and Hart, 2013 [1])...
June 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Louis C Grandizio, Steven Maschke, Peter J Evans
Cubital tunnel syndrome (CuTS) is the second most common compressive neuropathy in the upper extremity. There are considerable diagnostic and therapeutic challenges associated with treating patients after a failed primary procedure for CuTS. Distinguishing cases of recurrence versus persistence and identifying concomitant pathology can guide treatment. Conditions that mimic CuTS must be carefully ruled out and coexisting dysfunction of the medial antebrachial cutaneous nerve needs to be addressed. Results of revision procedures are not as reliable as primary procedures for CuTS; however, improvements in pain and paresthesias are noted in approximately 75% of patients...
June 8, 2018: Journal of Hand Surgery
Hee Sung Chae, Sung Min Han, Ha Neul Lee, Hyun Jong Jeon, Young Joon Seo
Pyoderma gangrenosum (PG) is primarily, a sterile, inflammatory, neutrophilic dermatosis, characterized by recurrent cutaneous ulceration with mucopurulent or hemorrhagic exudate. The incidence of PG is uncertain, but it is estimated to be about 3-10 patients per million per year. It occurs most commonly on the lower legs, but has been reported at other sites of the body as well. The causes of PG are unknown, but about 50-70% of cases are associated with other diseases, mainly inflammatory bowel disease. We hereby report a case of PG in a 21-year-old male, with a history of ulcerative colitis (UC)...
June 14, 2018: Journal of Audiology & Otology
Özge Vural Topuz, Fatma Arzu Görtan, Zübeyde Rana Kaya Döner, Çetin Önsel, Haluk Burçak Sayman
OBJECTIVE: We investigated the utility of PET/CT in cutaneous melanoma (CM) patients with pathological negative sentinel lymph nodes (SLN), within the first year. METHODS: The results of PET/CTs and SLN biopsy (SLNB) in 65 patients (39 male and 26 female, mean age 53.8) with a PET/CT in the first postoperative year were evaluated. Within this cohort, the utility of early PET/CT imaging was assessed in patients with negative SLNB. McNemar test was used to compare PET/CT findings with SLNB results...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Julia Luz, Daniel Zweifel, Martin Hüllner, Marco Bühler, Martin Rücker, Bernd Stadlinger
BACKGROUND: Bone necrosis of the jaw is a serious condition with a broad differential diagnosis of pathologies such as cutaneous histiocytosis, bone metastases or malignant tumours. In addition to the most common cause, medication related osteonecrosis of the jaw (MRONJ), one must consider a number of other causes, such as histiocytosis. Langerhans cell histiocytosis (LCH) is a histiocytic disorder with a large spectrum of clinical manifestations and with possible involvement of a variety of organs...
June 8, 2018: BMC Oral Health
Anna E Boniakowski, Andrew S Kimball, Amrita Joshi, Matt Schaller, Frank M Davis, Aaron denDekker, Andrea T Obi, Bethany B Moore, Steve L Kunkel, Katherine A Gallagher
Macrophages play a critical role in the establishment of a regulated inflammatory response following tissue injury. Following injury, CCR2+ monocytes are recruited from peripheral blood to wound tissue, and direct the initiation and resolution of inflammation that is essential for tissue repair. In pathologic states where chronic inflammation prevents healing, macrophages fail to transition to a reparative phenotype. Using a murine model of cutaneous wound healing, we found that CCR2-deficient mice (CCR2-/- ) demonstrate significantly impaired wound healing at all time points post-injury...
June 7, 2018: European Journal of Immunology
Delia Botezatu, Mihaela Tovaru, Simona-Roxana Georgescu, Antoanela Curici, Calin Giurcaneanu
Background: Psoriasis vulgaris is a chronic inflammatory hyper-proliferative disease of the skin, scalp, nails, and joints. It has been hypothesized that prolactin (PRL) may modulate the skin immune system and be involved in the pathogenesis of psoriasis. Psoriasis exerts significant, negative impact on patients' quality of life. Relatively high rates of depression are reported in patients with psoriasis. Objectives: The aim of this work was to study the possible role of PRL in the pathogenesis of psoriasis and its correlation with the disease activity, clinically, molecular and emotional status of patients...
March 2018: Mædica
Tom R Kupfer, Daniel M T Fessler
Currently, disgust is regarded as the main adaptation for defence against pathogens and parasites in humans. Disgust's motivational and behavioural features, including withdrawal, nausea, appetite suppression and the urge to vomit, defend effectively against ingesting or touching sources of pathogens. However, ectoparasites do not attack their hosts via ingestion, but rather actively attach themselves to the body surface. Accordingly, by itself, disgust offers limited defence against ectoparasites. We propose that, like non-human animals, humans have a distinct ectoparasite defence system that includes cutaneous sensory mechanisms, itch-generation mechanisms and grooming behaviours...
July 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Julius Katzmann, Carsten Schürfeld, Winfried März, Ulrich Laufs
Xanthomas are visibly deforming cholesterol deposits that develop after long-term exposure to high serum low-density lipoprotein cholesterol concentrations. We present the case of a 10-year-old boy suffering from homozygous familial hypercholesterolemia with generalized atherosclerosis and large xanthomas. The case impressively demonstrates the potential of low-density lipoprotein cholesterol lowering to rapidly regress pathologic cutaneous manifestations of hypercholesterolemia.
June 1, 2018: Journal of Clinical Lipidology
Jonathan L Curry, Michael T Tetzlaff, Sa A Wang, Gene Landon, Nail Alouch, Sapna P Patel, Priyadharsini Nagarajan, Shiva Gupta, Phyu P Aung, Catherine E Devine, Joseph D Khoury, Sanam Loghavi, Victor G Prieto, Courtney D DiNardo, Jeffrey E Gershenwald
Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobiliary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies...
June 1, 2018: American Journal of Dermatopathology
X X Zhang, Y Fang, L B Xu, S F Xu, Z G Zhao, C Sun, P Q Ma, T Liu, S J Yu, W J Zhang
Objective: To evaluate the clinical value of preoperative (18)F-Fludeoxyglucose ((18)F-FDG PET-CT) in lymphatic metastasis diagnosis of cutaneous melanoma on extremities and trunk. Methods: 112 patients with cutaneous melanoma pathologically of extremities and trunk from January 2006 to December 2016, who received (18)F-FDG PET-CT examination preoperatively, were retrospectively reviewed. The correlations between the maximal diameters of lymph nodes, the maximal standard uptake value (SUV) and the diagnostic impression grades of PET-CT examination, and the final pathological diagnosis were analyzed...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
S Geller, M Pulitzer, P L Myskowski
Follicular mucinosis (FM) can present as an acneiform eruption, and is usually a benign variant of primary FM unrelated to cutaneous T-cell lymphoma (CTCL). We report two cases of women in their twenties who presented with an acneiform rash on the face, arms and back. In both cases, pathological evaluation of the facial papules revealed predominantly mucinous degeneration of the follicular epithelium, with insufficient lymphocytic infiltration or atypia to diagnose mycosis fungoides. These cases are similar to previous reports of acneiform FM...
May 30, 2018: Clinical and Experimental Dermatology
Antonio Dionízio De Albuquerque Neto, André Vitor Alves Araújo, Daniel Assunção Cerqueira, Lorenzzo De Angeli Cesconetto, Nilton Provenzano, Eder Magno Ferreira de Oliveira
Paracoccidioidomycosis is a fungal infection initially described in Brazil in 1908 by Adolfo Lutz. Manifestation of this disease depends on numerous factors, such as microorganism virulence, hormonal profile, genetic predisposition, nutrition, and immune system. It is characterized classically by cutaneous lesions, lymphadenopathy, and pulmonary involvement. It presents male predilection, which can be explained by the protective effect of female hormones. Classic presentation within oral cavity is a superficial ulcer characterized by hemorrhagic dots of moriform aspect...
2018: Case Reports in Otolaryngology
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