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Cutaneous pathology

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https://www.readbyqxmd.com/read/29041952/the-response-of-muscle-progenitor-cells-to-cutaneous-thermal-injury
#1
Yusef Yousuf, Marc G Jeschke, Ahmed Shah, Ali-Reza Sadri, Andrea-Kaye Datu, Pantea Samei, Saeid Amini-Nik
BACKGROUND: Severe burn results in a systemic response that leads to significant muscle wasting. It is believed that this rapid loss in muscle mass occurs due to increased protein degradation combined with reduced protein synthesis. Alterations in the microenvironment of muscle progenitor cells may partially account for this pathology. The aim of this study was to ascertain the response of muscle progenitor cells following thermal injury in mice and to enlighten the cellular cascades that contribute to the muscle wasting...
October 17, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29026613/a-case-of-generalized-argyria-presenting-with-muscle-weakness
#2
Inha Jung, Eun-Jeong Joo, Byung Seong Suh, Cheol-Bae Ham, Ji-Min Han, You-Gyung Kim, Joon-Sup Yeom, Ju-Yeon Choi, Ji-Hye Park
BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. CASE PRESENTATION: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29024285/effect-of-a-high-cholesterol-diet-on-lipoprotein-metabolism-and-xanthoma-formation-in-rabbits
#3
Hao Hu, Yak Gao, Jing Tang, Yaozh Zhao, Hui Wang, Hua Jiang
BACKGROUND: Xanthelasma is the most common type of cutaneous xanthoma and often occurs on the eyelids. Xanthoma has been reported to be highly correlated with abnormal lipoprotein metabolism. AIMS: In this study, we wanted to investigate the effects of a high-cholesterol diet on xanthoma formation and lipoprotein metabolism in rabbits. METHODS: In animals fed with high-cholesterol diet, deteced plasma lipid [ie, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (L-DLC)] levels and pathology of xanthoma...
October 11, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29021537/elevated-levels-of-ccr6-t-helper-22-cells-correlate-with-skin-and-renal-impairment-in-systemic-lupus-erythematosus
#4
Wei Zhong, Yanfang Jiang, Hongshuang Ma, Jiang Wu, Zhenyu Jiang, Ling Zhao
Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of pathological features. Our study investigated the potential role of CCR6(+) T cells in organ impairment of SLE patients. We analyzed CCR6(+/-) T cell subset populations and compared the concentrations of IL-22, IFN-γ, TNF-α, and IL-17A cytokines in 67 patients with newly diagnosed SLE and 26 healthy controls. We found that SLE patients had elevated percentages of CCR6(+) T, CCR6(+) Th22, Th17, Th17.1, and CCR6(-) Th2 cell subsets, along with increased concentrations of IL-22, IFN-γ, TNF-α, and IL-17 cytokines...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29019164/tuberculosis-of-the-breast-in-togo-a-series-of-28-presumed-cases
#5
T Darré, M Tchaou, B N'Timon, A A Patassi, A Aboubakari, L Sonhaye, A Bassowa, K Amegbor, G Napo-Koura
Our study aimed to describe the epidemiological, clinical and histological aspects of mammary tuberculosis in Togo. This is a descriptive cross-sectional study of breast tuberculosis for which the diagnosis was presumed on histological grounds in the pathology department (LAP) of the Lomé Tokoin university hospital from January 1995 to December 2016 (20 years). A total of 28 presumed cases of mammary tuberculosis were identified. There were 26 women and 2 men, with an average age of 34.2 ± 0.3 years. The clinical signs were nodule (84...
October 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#6
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994134/first-line-treatment-in-lymphomatoid-papulosis-a-retrospective-multicentre-study
#7
R Fernández-de-Misa, B Hernández-Machín, O Servitje, F Valentí-Medina, L Maroñas-Jiménez, P L Ortiz-Romero, J Sánchez Schmidt, R M Pujol, F Gallardo, I Pau-Charles, M P García Muret, S Pérez Gala, C Román, J Cañueto, L Blanch Rius, R Izu, A Ortiz-Brugués, R M Martí, M Blanes, M Morillo, P Sánchez, Y Peñate, J Bastida, A Pérez Gil, I Lopez-Lerma, C Muniesa, T Estrach
BACKGROUND: Data regarding response to treatment in lymphomatoid papulosis (LyP) are scarce. AIM: To assess the daily clinical practice approach to LyP and the response to first-line treatments. METHODS: This was a retrospective study enrolling 252 patients with LyP. RESULTS: Topical steroids, methotrexate and phototherapy were the most common first-line treatments, prescribed for 35%, 20% and 14% of the patients, respectively...
October 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28984696/heterotopic-cutaneous-meningioma-an-unusual-presentation-occurring-in-a-patient-with-a-remote-history-of-intracranial-meningioma
#8
Chibuike Enwereuzo, Luis Moral, Jean M Henneberry
Meningioma is a neoplasm of the meninges, which usually occurs in intracranial sites. Extracranial meningioma has been frequently reported in the sinonasal tract and skull bone, often as extension of intracranial meningiomas. Isolated heterotopic meningioma without contiguous intracranial lesion is extremely rare. A 56-year-old woman presented in December 2015 with 2 firm subcutaneous scalp masses; one in the left lateral (temporal) and the other in the left superior (parietal) region. The clinical impression was that of lipoma...
September 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28984303/analysis-of-clinically-relevant-somatic-mutations-in-high-risk-head-and-neck-cutaneous-squamous-cell-carcinoma
#9
Catherine Zilberg, Matthew Weicai Lee, Bing Yu, Bruce Ashford, Spiridoula Kraitsek, Marie Ranson, Kerwin Shannon, Mark Cowley, N Gopalakrishna Iyer, Carsten E Palme, Sydney Ch'ng, Tsu-Hui Hubert Low, Sandra O'Toole, Jonathan R Clark, Ruta Gupta
Cutaneous squamous cell carcinoma is the second most prevalent malignancy, most frequently occurring in the head and neck (head and neck cutaneous squamous cell carcinoma). Treatment of locally advanced or metastatic disease is associated with functional morbidity and disfigurement. Underlying genetic mechanisms are poorly understood. Targeted sequencing of 48 clinically relevant genes was performed on DNA extracted from formalin-fixed and paraffin-embedded high-risk primary head and neck cutaneous squamous cell carcinomas that remained non-metastatic at minimum follow-up of 24 months...
October 6, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28983940/outline-of-guidelines-for-the-management-of-vasculitis-and-vascular-disorders-in-japan-2016-revised-edition
#10
Takaharu Ikeda, Fukumi Furukawa, Tamihiro Kawakami, Naoko Ishiguro, Miwa Uzuki, Shoichi Ozaki, Kensei Katsuoka, Takeshi Kono, Seiji Kawana, Masanari Kodera, Takashi Sawai, Yasuyuki Sawada, Mariko Seishima, Akiko Tanikawa, Ko-Ron Chen, Minoru Hasegawa
The proposal by the 1994 International Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitides (CHCC1994) and by the CHCC2012 markedly influenced the classification and way of considering cutaneous vasculitis. In the proposal by the CHCC1994, hypersensitivity angiitis was defined as an equivalent pathological condition to microscopic polyangiitis or cutaneous leukocytoclastic angiitis (CLA), and it was not adopted as a disease name. However, CLA which was positioned as a type of small-vessel vasculitis is only a pathological name...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28979632/-staphylococcal-toxic-shock-syndrome-at-a-chronic-hemodialysis
#11
Hassan Alaoui, Ayoub Belhadj, Younes Aissaoui, Rachid Seddiki, Mohamed Zoubir, Mohamed Bougalem
Staphylococcal toxic shock syndrome is an acute and systemic infectious syndrome associated with the super-antigenic activity of staphylococcal toxins. It is a pathology that is rather rare but remains burdened with a considerable mortality despite the therapeutic management. The gateway is usually cutaneous with secondary bacteremic spread could be subject to preventive measures. We report the case of a rapidly fatal staphylococcal toxic shock, developed in a chronic hemodialysis whose entry from the arteriovenous fistula was suspected...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28974385/inhibition-of-rubella-virus-replication-by-the-broad-spectrum-drug-nitazoxanide-in-cell-culture-and-in-a-patient-with-a-primary-immune-deficiency
#12
Ludmila Perelygina, Timo Hautala, Mikko Seppänen, Adebola Adebayo, Kathleen E Sullivan, Joseph Icenogle
Persistent rubella virus (RV) infection has been associated with various pathologies such as congenital rubella syndrome, Fuchs's uveitis, and cutaneous granulomas in patients with primary immune deficiencies (PID). Currently there are no drugs to treat RV infections. Nitazoxanide (NTZ) is an FDA-approved drug for parasitic infections, and has been recently shown to have broad-spectrum antiviral activities. Here we found that empiric 2-month therapy with oral NTZ was associated in the decline/elimination of RV antigen from lesions in a PID patient with RV positive granulomas, while peginterferon treatment had no effect...
September 30, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28973431/arteriovenous-malformations-of-the-temporalis-muscle-a-comprehensive-review
#13
Javier Ros de San Pedro, Beatriz Cuartero Pérez, Belén Ferri Ñíguez, Víctor Villanueva San Vicente
Arteriovenous malformations of the temporalis muscle (TM-AVMs) are rare lesions commonly considered as a variant of scalp AVMs. A study was designed in order to analyze TM-AVMs features and to confirm them as a certain entity different from scalp AVMs. Seven TM-AVMs cases (5 from literature plus 2 from our database) were studied. Clinical, epidemiological, radiological, and therapeutic data were analyzed and compared to common scalp AVMs features. All TM-AVMs presented as large soft tumor-like masses on the temporal region (mean diameter: 6 cm)...
July 20, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28970830/immunomodulatory-monoclonal-antibodies-in-combined-immunotherapy-trials-for-cutaneous-melanoma
#14
REVIEW
Mariana Aris, José Mordoh, María Marcela Barrio
In the last few years, there has been a twist in cancer treatment toward immunotherapy thanks to the impressive results seen in advanced patients from several tumor pathologies. Cutaneous melanoma is a highly mutated and immunogenic tumor that has been a test field for the development of immunotherapy. However, there is still a way on the road to achieving complete and long-lasting responses in most patients. It is desirable that immunotherapeutic strategies induce diverse immune reactivity specific to tumor antigens, including the so-called neoantigens, as well as the blockade of immunosuppressive mechanisms...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28969251/primary-cutaneous-amyloidosis-a-clinical-histopathological-and-immunofluorescence-study
#15
Krati Mehrotra, Rupali Dewan, Jagannath V Kumar, Abhinav Dewan
INTRODUCTION: Primary Localized Cutaneous Amyloidosis (PLCA) is a relatively rare chronic condition characterized by amyloid deposition in dermis without associated deposits in internal organs. Histopathology of cutaneous amyloidosis using Haematoxylin and Eosin (H&E) stain shows eosinophilic hyaline material in papillary dermis, which can be further confirmed by Congo Red (CR) staining or Direct Immunofluorescence (DIF) Test or immunohistochemistry. AIM: To assess the concordance between the clinical, histo pathological and DIF findings in various subtypes of (PLCA)...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966493/clinical-manifestations-of-nocardiosis-study-of-risk-factors-and-outcomes-in-a-tertiary-care-hospital
#16
Teena Wadhwa, Usha Baveja, Navin Kumar, Deepak Govil, Sharmila Sengupta
PURPOSE: The aim of this study is to evaluate the predisposing risk factors, clinical presentations, laboratory parameters, and treatments taken and outcomes in patients of nocardiosis in the span of 5 years in a tertiary care hospital. MATERIALS AND METHODS: The patients whose specimens showed Nocardia like organism in Gram-staining, Kinyoun staining and characteristic colonies in culture were included in the retrospective analysis study. Retrospective analysis of associated risk factors, clinical presentations, and radiological findings was performed...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28965629/cd30-t-cell-enriched-primary-cutaneous-cd4-small-medium-sized-pleomorphic-t-cell-lymphoma-a-distinct-variant-of-indolent-cd4-t-cell-lymphoproliferative-disease
#17
REVIEW
Cynthia M Magro, Luke C Olson, Clifton G Fulmer
Primary cutaneous CD4+ small/medium sized pleomorphic T-cell lymphoma (SMPTCL) is unique among the peripheral T-cell lymphomas because of its indolent nature, typically presenting as a solitary nodule or plaque in the head and neck area of middle-aged and older adults. Recent studies have suggested a follicular helper cell origin for these lesions. MATERIALS AND METHODS: A retrospective review was conducted on all cases of SMPTCL diagnosed between 2008 and 2017. The goal of our study was to better categorize the clinical, pathologic and molecular features of cases of SMPTCL showing a significant degree of CD30 neoplastic large cell infiltration...
October 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28956538/epidemiology-of-panton-valentine-leukocidin-harbouring-staphylococcus-aureus-in-cutaneous-infections-from-iran-a-systematic-review-and-meta-analysis
#18
Milad Shahini Shams Abadi, Iraj Nikokar, Seyedeh Mahsan Hoseini Alfatemi, Yalda Malekzadegan, Abdolah Azizi, Hadi Sedigh Ebrahim-Saraie
Panton-Valentine Leukocidin (PVL) producing Staphylococcus aureus has been associated with severity of skin infections and pathology that suggest a major role in pathogenicity. The present study aimed to determine the overall prevalence of PVL harbouring S. aureus isolates from cutaneous infections in Iran. A systematic search was performed by using Medline electronic databases (PubMed) from the papers published by Iranian authors to the end of March 2017. Ten publications which met our inclusion criteria were then selected for data extraction and analysis by Comprehensive Meta-Analysis Software...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28954874/fibrous-arthropathy-associated-with-morphea-a-new-cause-of-diffuse-acquired-joint-contractures
#19
Etienne Merlin, Sylvain Breton, Sylvie Fraitag, Jean-Louis Stéphan, Carine Wouters, Christine Bodemer, Brigitte Bader-Meunier
Etiologies for childhood-onset diffuse joint contractures encompass a large group of inherited disorders and acquired diseases, in particular a subtype of juvenile idiopathic arthritis called "dry polyarthritis," dermatomyositis, and systemic sclerosis. We report on 2 boys, aged 5 and 8 years, who developed acquired symmetric painless joint contractures preceding the development of superficial plaques of morphea by 7 to 13 months. There was no other clinical involvement, biological inflammation, or autoantibodies...
October 2017: Pediatrics
https://www.readbyqxmd.com/read/28954233/lymphatic-vessels-balance-viral-dissemination-and-immune-activation-following-cutaneous-viral-infection
#20
Christopher P Loo, Nicholas A Nelson, Ryan S Lane, Jamie L Booth, Sofia C Loprinzi Hardin, Archana Thomas, Mark K Slifka, Jeffrey C Nolz, Amanda W Lund
Lymphatic vessels lie at the interface between peripheral sites of pathogen entry, adaptive immunity, and the systemic host. Though the paradigm is that their open structure allows for passive flow of infectious particles from peripheral tissues to lymphoid organs, virus applied to skin by scarification does not spread to draining lymph nodes. Using cutaneous infection by scarification, we analyzed the effect of viral infection on lymphatic transport and evaluated its role at the host-pathogen interface. We found that, in the absence of lymphatic vessels, canonical lymph-node-dependent immune induction was impaired, resulting in exacerbated pathology and compensatory, systemic priming...
September 26, 2017: Cell Reports
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