Yunde Dou, Rusong Zhao, Han Wu, Zhiheng Yu, Changjian Yin, Jie Yang, Chaoyan Yang, Xiaohua Luan, Yixiao Cheng, Tao Huang, Yuehong Bian, Shan Han, Yuqing Zhang, Xin Xu, Zi-Jiang Chen, Han Zhao, Shigang Zhao
Polycystic ovary syndrome (PCOS) is a complex disorder. Genome-wide association studies (GWAS) have identified several genes associated with this condition, including DENND1A. DENND1A encodes a clathrin-binding protein that functions as a guanine nucleotide exchange factor involved in vesicular transport. However, the specific role of DENND1A in reproductive hormone abnormalities and follicle development disorders in PCOS remain poorly understood. In this study, we investigated DENND1A expression in ovarian granulosa cells (GCs) from PCOS patients and its correlation with hormones...
April 23, 2024: Science China. Life Sciences