Julliane V Joviano-Santos, Priscila A C Valadão, Matheus P S Magalhães-Gomes, Lorena F Fernandes, Danuza M Diniz, Thatiane C G Machado, Kivia B Soares, Marina S Ladeira, Andre R Massensini, Marcus V Gomez, Aline S Miranda, Juan C Tápia, Cristina Guatimosim
NEW FINDINGS: What is the central question of this study? We investigated the action of intrathecal administration of a novel toxin (CTK01512-2) in a mouse model for Huntington´s disease (HD). We asked if spinal cord neurons can represent a therapeutic target, as the spinal cord seems to be involved in HD motor-symptoms. Pharmacological approaches focusing on the spinal cord and skeletal muscles might represent a more feasible strategy. What is the main finding and its importance? We provided evidence of a novel, local, neuroprotector effect of CTK01512-2, paving a path for the development of approaches to treat HD-motor symptoms beyond the brain...
April 27, 2022: Experimental Physiology