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https://www.readbyqxmd.com/read/28428518/-a-case-of-malignant-lymphoma-of-the-jejunum-that-developed-stenosis-and-perforation-after-a-complete-response-to-chemotherapy
#1
Atsushi Sugimoto, Masaharu Tada, Tomoe Taji, Yudai Houjo, Yu Kanokogi, Masaaki Hirata, Yusuke Fujita, Yusuke Kawasaki, Takashi Sakamoto, Junichi Yoshikawa, Hideaki Iwama, Shinichiro Usuki, Yoshiharu Shirakata, Jun Tamura, Atsuhiko Maki
A 57-year-old woman was admitted owing to epigastric pain.Abdominal computed tomography demonstrated a tumor in the origin of the jejunum.After an endoscopic biopsy, we diagnosed diffuse large B-cell lymphoma.We treated her with CHOP chemotherapy because pancreaticoduodenectomy is highly invasive.After 1 course of chemotherapy, the tumor was reduced.However, she developed a jejunal stenosis; therefore, we performed laparoscopic gastrojejunostomy.Furthermore, she developed perforated peritonitis on the sixth day after the surgery, and therefore, an emergency partial jejunum resection was performed...
April 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28428474/evaluation-of-absorbed-dose-for-cbct-in-image-guided-radiation-therapy-comparison-of-each-devices-and-facilities
#2
Yumiko Kitazato, Noriyuki Kuga, Katsutoshi Shirieda, Masahiro Enzaki, Yuji Nakaguchi, Yoshinobu Shimohigashi, Toshihisa Kawasaki, Masahiko Toyoda, Daisuke Kawahara, Fujio Araki, Shinji Kawamura
Recently, intensity-modulated radiation therapy (IMRT) is used worldwide, highly accurate verification of the location using image-guided radiation therapy (IGRT) has become critical. However, the use of cone-beam computed tomography (CBCT) to ascertain the location each time raises concerns about its influence on radiotherapy dosage and increased radiation exposure. The purpose of this study was to measure the absorbed dose using nine kilovoltage (kV) devices and two megavoltage (MV) devices (total 11 devices) at eight facilities, compare the absorbed dose among the devices, and assess the characteristics of the respective devices to ensure optimal clinical operation...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/28427414/observational-study-of-interleukin-21-il-21-does-not-distinguish-kawasaki-disease-from-other-causes-of-fever-in-children
#3
Rachel Engelberg, Meghan Martin, Brian H Wrotniak, Mark Daniel Hicar
BACKGROUND: Kawasaki disease (KD) is a febrile childhood vasculitis of unknown etiology. The diagnosis is highly concerning as over a quarter of children who fail to receive timely treatment with intravenous immunoglobulin (IVIG) will develop coronary aneurysms. Diagnosis relies on proper symptomatology and is supported by non-specific markers of inflammation. Previous studies have identified elevated plasma levels of interleukin-21 (IL-21) as a sensitive and specific biomarker in KD...
April 20, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28427379/novel-mutation-identified-in-severe-early-onset-tumor-necrosis-factor-receptor-associated-periodic-syndrome-a-case-report
#4
Suhas M Radhakrishna, Amy Grimm, Lori Broderick
BACKGROUND: Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1-3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis. CASE PRESENTATION: Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. She was initially diagnosed with incomplete Kawasaki Disease and received IVIG and infliximab; however, her fevers quickly recurred...
April 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28426790/lethality-of-mice-bearing-a-knockout-of-the-ngly1-gene-is-partially-rescued-by-the-additional-deletion-of-the-engase-gene
#5
Haruhiko Fujihira, Yuki Masahara-Negishi, Masaru Tamura, Chengcheng Huang, Yoichiro Harada, Shigeharu Wakana, Daisuke Takakura, Nana Kawasaki, Naoyuki Taniguchi, Gen Kondoh, Tadashi Yamashita, Yoko Funakoshi, Tadashi Suzuki
The cytoplasmic peptide:N-glycanase (Ngly1 in mammals) is a de-N-glycosylating enzyme that is highly conserved among eukaryotes. It was recently reported that subjects harboring mutations in the NGLY1 gene exhibited severe systemic symptoms (NGLY1-deficiency). While the enzyme obviously has a critical role in mammals, its precise function remains unclear. In this study, we analyzed Ngly1-deficient mice and found that they are embryonic lethal in C57BL/6 background. Surprisingly, the additional deletion of the gene encoding endo-β-N-acetylglucosaminidase (Engase), which is another de-N-glycosylating enzyme but leaves a single GlcNAc at glycosylated Asn residues, resulted in the partial rescue of the lethality of the Ngly1-deficient mice...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28422845/response-to-benzodiazepines-and-the-clinical-course-in-malignant-catatonia-associated-with-schizophrenia-a-case-report
#6
Kazutaka Ohi, Aki Kuwata, Takamitsu Shimada, Toshiki Yasuyama, Yusuke Nitta, Takashi Uehara, Yasuhiro Kawasaki
BACKGROUND: Malignant catatonia (MC) is a disorder consisting of catatonic symptoms, hyperthermia, autonomic instability, and altered mental status. Neuroleptic malignant syndrome (NMS) caused by antipsychotics is considered a variant of MC. Benzodiazepine (BZD) medications are safe and effective treatments providing rapid relief from MC. This case study reports a detailed clinical course of a case of MC associated with schizophrenia initially diagnosed as NMS that responded successfully to BZDs but not to dantrolene...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422356/bilateral-femoral-neck-fractures-resulting-from-pregnancy-associated-osteoporosis-showed-bone-marrow-edema-on-magnetic-resonance-imaging
#7
Kyoko Kasahara, Nobuyuki Kita, Taku Kawasaki, Shinsuke Morisaki, Hiroko Yomo, Takashi Murakami
Femoral neck fractures resulting from pregnancy-associated osteoporosis is a rare condition. Herein, we report an undoubted case of pregnancy-associated osteoporosis in a 38-year-old primiparous patient with pre-existing anorexia nervosa who suffered bilateral femoral neck fractures in the third trimester and early post-partum period. Magnetic resonance imaging revealed femoral neck fractures as well as diffuse marrow edema involving both femoral heads, which are considered under ordinary circumstances as characteristic imaging findings of transient osteoporosis of the hip...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28417923/anemia-in-kawasaki-disease-hepcidin-as-a-potential-biomarker
#8
REVIEW
Ying-Hsien Huang, Ho-Chang Kuo
Kawasaki disease (KD) is an autoimmune-like disease and acute childhood vasculitis syndrome that affects various systems but has unknown etiology. In addition to the standard diagnostic criteria, anemia is among the most common clinical features of KD patients and is thought to have a more prolonged duration of active inflammation. In 2001, the discovery of a liver-derived peptide hormone known as hepcidin began revolutionizing our understanding of anemia's relation to a number of inflammatory diseases, including KD...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28417110/kawasaki-disease-and-labyrinthitis-an-underdiagnosed-complication
#9
Kyu Yeun Kim, Ki Hwan Kim, Yoon Ah Park, Young Joon Seo
Sensorineural hearing loss (SNHL) that is seldom cited as a Kawasaki disease (KD) complication is known as an additional, potentially severe, and frequently irreversible sequel. Furthermore the vestibular functions of KD have been underestimated and it could be an important complication combined with SNHL in KD. We described a case that a 4 year-old boy who developed vestibular loss with SNHL has recovered successfully with a combined treatment.
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28413914/prognostic-value-of-the-soluble-interleukin-2-receptor-level-after-patients-with-follicular-lymphoma-achieve-a-response-to-r-chop
#10
Kento Umino, Shin-Ichiro Fujiwara, Takashi Ikeda, Yumiko Toda, Shoko Ito, Kiyomi Mashima, Daisuke Minakata, Hirofumi Nakano, Ryoko Yamasaki, Yasufumi Kawasaki, Miyuki Sugimoto, Chihiro Yamamoto, Masahiro Ashizawa, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine, Kazuo Muroi, Yoshinobu Kanda
OBJECTIVES: Follicular lymphoma (FL) is a clinically and biologically heterogeneous disease. Therefore, it is important to identify factors that can predict its clinical outcome. METHODS: We retrospectively evaluated the usefulness of soluble interleukin-2 receptor (sIL-2R) levels after R-CHOP (posttreatment sIL-2R) in 72 patients with newly diagnosed FL who had either a complete response (CR) or partial response. With the use of a recursive partitioning analysis, we determined the cut-off values of post- and pretreatment sIL-2R levels that were associated with disease progression, which corresponded to 486...
April 17, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28409890/four-state-molecular-shuttling-of-2-rotaxanes-featuring-ammonium-aniline-anilinium-and-tetra-ethylene-glycol-stations-in-response-to-acid-base-and-alkali-metal-cation-stimuli
#11
Masaki Kimura, Takuma Mizuno, Masahiro Ueda, Shinobu Miyagawa, Tsuneomi Kawasaki, Yuji Tokunaga
In this study we synthesized [2]rotaxanes possessing three recognition sites-a dialkylammonium, an alkylarylamine, and a tetra(ethylene glycol) station-in their dumbbell-like axle component and dibenzo[24]crown-8 (DB24C8) as their macrocyclic component. These [2]rotaxanes behaved as four-state molecular shuttles: (i) under acidic conditions, the DB24C8 unit encircled both the dialkylammonium and alkylarylammonium stations; (ii) under neutral conditions, the dialkylammonium unit was the predominant station for the DB24C8 component; (iii) under basic conditions, when both ammonium centers were deprotonated, the alkylarylamine unit became a suitable station for the DB24C8 component; and (iv) under basic conditions in the presence of an alkali metal cation, the tetra(ethylene glycol) unit recognized the DB24C8 component through cooperative binding of the alkali metal ion...
April 13, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28408868/perivascular-accumulation-of-%C3%AE-sheet-rich-proteins-in-offspring-brain-following-maternal-exposure-to-carbon-black-nanoparticles
#12
Atsuto Onoda, Takayasu Kawasaki, Koichi Tsukiyama, Ken Takeda, Masakazu Umezawa
Environmental stimulation during brain development is an important risk factor for the development of neurodegenerative disease. Clinical evidence indicates that prenatal exposure to particulate air pollutants leads to diffuse damage to the neurovascular unit in the developing brain and accelerates neurodegeneration. Maternal exposure to carbon black nanoparticles (CB-NPs), used as a model for particulate air pollution, induces long-lasting diffuse perivascular abnormalities. We aimed to comprehensively characterize the perivascular abnormalities related to maternal NPs exposure using Fourier transform infrared microspectroscopy (in situ FT-IR) and classical staining analysis...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28408126/high-risk-of-coronary-artery-aneurysms-in-infants-younger-than-6-months-of-age-with-kawasaki-disease
#13
Andrea P Salgado, Negar Ashouri, Erika K Berry, Xiaoying Sun, Sonia Jain, Jane C Burns, Adriana H Tremoulet
OBJECTIVES: To characterize the clinical presentation and outcome in infants <6 months of age with Kawasaki disease (KD) and to describe the use of newer anti-inflammatory therapies in this young population. STUDY DESIGN: We evaluated 88 infants <6 months old and 632 ≥6 months old treated for KD. We compared differences in laboratory data, response to treatment, and coronary artery outcomes between the 2 cohorts. Fisher exact test was used to analyze categorical variables, whereas the Wilcoxon rank sum test was used for continuous variables...
April 10, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28407827/-values-of-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-predicting-sensitivity-to-intravenous-immunoglobulin-in-kawasaki-disease
#14
Ying-Di Yuan, Jun Sun, Peng-Fei Li, Chun-Lei Wei, Yan-Hui Yu
OBJECTIVE: To study the values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting the sensitivity to intravenous immunoglobulin (IVIG) in Kawasaki disease (KD). METHODS: A retrospective cohort study was conducted in 404 children with newly diagnosed KD. The data on routine blood tests, NLR, and PLR were collected before and after IVIG treatment. The receiver operating characteristic (ROC) curve was used to determine the cut-off values of NLR and PLR in predicting the insensitivity to IVIG...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28405375/a-modified-nanosuit%C3%A2-preserves-wet-samples-in-high-vacuum-direct-observations-on-cells-and-tissues-in-field-emission-scanning-electron-microscopy
#15
Yasuharu Takaku, Hiroshi Suzuki, Hideya Kawasaki, Isao Ohta, Daisuke Ishii, Satoshi Hirakawa, Takami Tsutsui, Haruko Matsumoto, Sayuri Takehara, Chinatsu Nakane, Kana Sakaida, Chiaki Suzuki, Yoshinori Muranaka, Hirotoshi Kikuchi, Hiroyuki Konno, Masatsugu Shimomura, Takahiko Hariyama
Although field-emission scanning electron microscopy (FE-SEM) has proven very useful in biomedical research, the high vacuum required (10(-3) to 10(-7) Pa) precludes direct observations of living cells and tissues at high resolution and often produces unwanted structural changes. We have previously described a method that allows the investigator to keep a variety of insect larvae alive in the high vacuum environment of the electron microscope by encasing the organisms in a thin, vacuum-proof suit, the 'NanoSuit®'...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28405208/a-case-of-atypical-kawasaki-disease-with-giant-coronary-artery-aneurysm-containing-thrombus
#16
Eynaud S Micallef, Montalto S Attard, V Grech
INTRODUCTION: Kawasaki disease (KD) is an acute febrile, systemic vasculitic syndrome of unknown etiology, occurring primarily in children younger than 5 years of age. Administration of IVIG within the first 10 days after onset of fever in combination with high dose aspirin reduces the risk of coronary artery damage in KD. Though rare, giant aneurysms of the coronary arteries may develop in untreated cases and prove extremely challenging to manage. CASE PRESENTATION: A 9-month-old Caucasian boy presented to our paediatric emergency department with a 4-week history of intermittent pyrexia and irritability...
July 2016: Images in Paediatric Cardiology
https://www.readbyqxmd.com/read/28401742/encephalopathy-and-pancreatitis-in-a-3-year-old-girl-with-kawasaki-disease
#17
Marie Mitani, Kazumi Ehara, Kosei Araki, Makoto Anzo, Masahiro Bamba
No abstract text is available yet for this article.
April 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28400731/il-1-inhibition-may-have-an-important-role-in-treating-refractory-kawasaki-disease
#18
REVIEW
Perrine Dusser, Isabelle Koné-Paut
Kawasaki disease (KD) is an acute inflammatory vasculitis occurring in young children before 5 years and representing at this age, the main cause of acquired heart disease. A single infusion of 2 g/kg of intravenous immunoglobulins along with aspirin has reduced the frequency of coronary artery aneurysms from 25 to 5%. However, 10-20% of patients do not respond to standard treatment and have an increased risk of cardiac complications and death. The development of more potent therapeutic approaches of KD is an urgent need...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28398645/crispr-cas9-mediated-gene-knockout-in-the-mouse-brain-using-in-utero-electroporation
#19
Yohei Shinmyo, Hiroshi Kawasaki
This unit describes a highly efficient and rapid procedure for brain-specific disruption of genes in the developing mouse brain using pX330 plasmids expressing humanized Cas9 and single-guide RNAs (sgRNAs) against target genes. The pX330 plasmids are delivered into the rodent brain using in utero electroporation. Focusing on the Satb2 gene, which encodes an AT-rich DNA-binding transcription factor, we found that the introduction of pX330-Satb2 induced insertion/deletion (indel) mutations near the predicted cleavage site in the Satb2 gene, resulting in a dramatic reduction of Satb2 expression in post-mitotic neurons...
April 10, 2017: Current Protocols in Neuroscience
https://www.readbyqxmd.com/read/28391764/physiological-positioning-strategy-alters-condylar-position-after-mandibular-ramus-sagittal-split-osteotomies-for-mandibular-prognathism
#20
Seigo Ohba, Hiroya Ozaki, Kei-Ichirou Miura, Takamitsu Koga, Takako Kawasaki, Noriaki Yoshida, Izumi Asahina
OBJECTIVE: The aim of this study was to elucidate the physiological position of the proximal segment for postoperative jaw movement in patients with mandibular prognathism. METHODS: Twenty-two patients with mandibular prognathism were treated by orthognathic surgery using bilateral mandibular sagittal split ramus osteotomies (SSRO) with a physiological positioning strategy. The skeletal stability was assessed, and the movement of the proximal segment was evaluated by cephalography and computed tomography performed preoperatively, immediately postoperatively, and one year postoperatively...
April 8, 2017: Cranio: the Journal of Craniomandibular Practice
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