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https://www.readbyqxmd.com/read/29144443/a-genomic-survey-of-scpp-family-genes-in-fishes-provides-novel-insights-into-the-evolution-of-fish-scales
#1
Yunyun Lv, Kazuhiko Kawasaki, Jia Li, Yanping Li, Chao Bian, Yu Huang, Xinxin You, Qiong Shi
The family of secretory calcium-binding phosphoproteins (SCPPs) have been considered vital to skeletal tissue mineralization. However, most previous SCPP studies focused on phylogenetically distant animals but not on those closely related species. Here we provide novel insights into the coevolution of SCPP genes and fish scales in 10 species from Otophysi. According to their scale phenotypes, these fishes can be divided into three groups, i.e., scaled, sparsely scaled, and scaleless. We identified homologous SCPP genes in the genomes of these species and revealed an absence of some SCPP members in some genomes, suggesting an uneven evolutionary history of SCPP genes in fishes...
November 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29143467/kawasaki-disease-an-ongoing-challenge
#2
Chui Han Chong, Senq-J Lee, Andrew Bullock, Linda Harris, Richard Loh, Geoff Knight, Kristina Rueter
No abstract text is available yet for this article.
November 16, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29143203/relapse-of-nephrotic-syndrome-triggered-by-kawasaki-disease
#3
Ryo Maeda, Yukihiko Kawasaki, Shigeo Suzuki, Shinichiro Ohara, Suyama Kazuhide, Mitsuaki Hosoya
Minor infections, allergies, insect bites, and bee stings are commonly reported causes of nephrotic syndrome (NS). Herein, we report, to the best of our knowledge, the first case of NS relapse due to Kawasaki disease (KD). An 8-year-old boy presented with high fever of 4-day duration. He had developed steroid-dependent NS at the age of 4 years and remained in remission after steroid and mizonbin therapy. Renal biopsy, performed at the age of four, showed minimal change (MC) disease. Upon examination, the patient fulfilled 5 of 6 criteria for KD under the Japanese diagnostic guidelines, with positive proteinuria...
November 15, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29142167/synergistic-cytotoxicity-caused-by-forming-a-complex-of-copper-and-2-9-dimethyl-1-10-phenanthroline-in-cultured-vascular-endothelial-cells
#4
Takehiro Nakamura, Eiko Yoshida, Tomoya Fujie, Fumihiko Ogata, Chika Yamamoto, Naohito Kawasaki, Toshiyuki Kaji
Organic-inorganic hybrid molecules, which are composed of organic-ligand(s) and metal(s), are indispensable as synthetic reagents in chemistry, but they have made very little in the way of contributions to biological research. Previously, we reported that the cytotoxicity of organic-inorganic hybrid molecules in vascular endothelial cells depends on interactions between the intramolecular metal and ligand, but remains independent of the hydrophobicity of the intramolecular metal(s). Herein, we show a synergistic cytotoxicity produced by forming a complex of copper and 2,9-dimethyl-1,10-phenanthroline in vascular endothelial cells that depends on the intracellular accumulation of copper...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29140936/increased-kawasaki-disease-incidence-associated-with-higher-precipitation-and-lower-temperatures-japan-1991-2004
#5
Joseph Y Abrams, Jennifer L Blase, Ermias B Belay, Ritei Uehara, Ryan A Maddox, Lawrence B Schonberger, Yosikazu Nakamura
BACKGROUND: Kawasaki disease (KD) is an acute febrile vasculitis which primarily affects children. The etiology of KD is unknown: while certain characteristics of the disease suggest an infectious origin, genetic or environmental factors may also be important. Seasonal patterns of KD incidence are well-documented, but it is unclear whether these patterns are caused by changes in climate or by other unknown seasonal effects. METHODS: The relationship between KD incidence and deviations from expected temperature and precipitation were analyzed using KD incidence data from Japanese nationwide epidemiological surveys (1991-2004) and climate data from 136 weather stations of the Japan Meteorological Agency...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29138379/-a-case-of-advanced-gastric-cancer-responding-to-neoadjuvant-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil-leading-to-a-pathological-complete-response
#6
Keishi Kawasaki, Dan Takeuchi, Takaaki Kaneko, Seiki Miura, Junichiro Kamiya, Yoji Miyahara, Kotaro Yoshimura, Akira Ogata
We report a 72-year-old woman who was initially diagnosed with locally advanced gastric cancer with involvement of the esophagus and pancreas. She received 3 courses of neoadjuvant chemotherapy(NAC)with docetaxel, cisplatin, and 5- fluorouracil(the DCF regimen)and achieved an excellent response. She underwent total gastrectomy with distal pancreatectomy, splenectomy, and D2 lymphadenectomy. Histological examination confirmed a pathological complete response. NAC chemotherapy can down stage/down size the disease and allow some patients to undergo curative radical surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29134187/method-for-evaluation-of-human-induced-pluripotent-stem-cell-quality-using-image-analysis-based-on-the-biological-morphology-of-cells
#7
Takashi Wakui, Tsuyoshi Matsumoto, Kenta Matsubara, Tomoyuki Kawasaki, Hiroshi Yamaguchi, Hidenori Akutsu
We propose an image analysis method for quality evaluation of human pluripotent stem cells based on biologically interpretable features. It is important to maintain the undifferentiated state of induced pluripotent stem cells (iPSCs) while culturing the cells during propagation. Cell culture experts visually select good quality cells exhibiting the morphological features characteristic of undifferentiated cells. Experts have empirically determined that these features comprise prominent and abundant nucleoli, less intercellular spacing, and fewer differentiating cellular nuclei...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29133274/gender-differences-in-the-impact-of-anemia-on-subclinical-myocardial-damage-and-cardiovascular-mortality-in-the-general-population-the-yamagata-takahata-study
#8
Yuki Honda, Tetsu Watanabe, Yoichiro Otaki, Harutoshi Tamura, Satoshi Nishiyama, Hiroki Takahashi, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Yoko Shibata, Tsuneo Konta, Ryo Kawasaki, Makoto Daimon, Yoshiyuki Ueno, Takeo Kato, Takamasa Kayama, Isao Kubota
BACKGROUND: Anemia has been shown to worsen cardiovascular diseases. However, it is unclear whether there is a gender difference in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population. METHODS: A prospective cohort study was conducted in a community based on annual health checks. Serum heart-type fatty acid binding protein (H-FABP) levels, which is a marker for myocardial damage, and blood counts were measured at baseline in subjects without previous cardiovascular diseases (n=3111)...
November 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29132503/gyrification-of-the-cerebral-cortex-requires-fgf-signaling-in-the-mammalian-brain
#9
Naoyuki Matsumoto, Yohei Shinmyo, Yoshie Ichikawa, Hiroshi Kawasaki
Although it has been believed that the evolution of cortical folds was a milestone, allowing for an increase in the number of neurons in the cerebral cortex, the mechanisms underlying the formation of cortical folds are largely unknown. Here we show regional differences in the expression of fibroblast growth factor receptors (FGFRs) in the developing cerebral cortex of ferrets even before cortical folds are formed. By taking the advantage of our in utero electroporation technique for ferrets, we found that cortical folding was impaired in the ferret cerebral cortex when FGF signaling was inhibited...
November 14, 2017: ELife
https://www.readbyqxmd.com/read/29131799/multi-slice-computed-tomography-assessment-of-everolimus-eluting-absorb-bioresorbable-scaffold-in-comparison-with-metallic-drug-eluting-stents-from-the-absorb-japan-randomized-trial
#10
Kengo Tanabe, Jeffrey J Popma, Ken Kozuma, Shigeru Saito, Toshiya Muramatsu, Sunao Nakamura, Atsuo Namiki, Yoshihiro Morino, Nobuhisa Hagiwara, Masaaki Uematsu, Tomohiro Kawasaki, Kenshi Fujii, Patrick W Serruys, Yoshinobu Onuma, Shihwa Ying, Hajime Kusano, Gregg W Stone, Takeshi Kimura
AIMS: Blooming artifacts limit accurate coronary assessment by multi-slice computed tomography (MSCT) in metallic stents. We sought to investigate whether bioresorbable vascular scaffold (BVS) could be better assessed by MSCT. Methods and Results: Among 400 patients in the randomized ABSORB Japan trial, a pre-specified MSCT sub-study was performed in 98 patients (103 lesions) in the BVS arm and 49 patients (49 lesions) in the cobalt chromium everolimus-eluting stent (CoCr-EES) arm at 13-month prior to follow-up angiography...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29131549/diagnosis-of-kawasaki-disease
#11
Surjit Singh, Ankur Kumar Jindal, Rakesh Kumar Pilania
Kawasaki disease (KD) is a medium vessel vasculitis with predilection for coronary arteries. Due to lack of a reliable confirmatory laboratory test, the diagnosis of KD is based on a constellation of clinical findings that appear in a typical temporal sequence. These diagnostic criteria have been modified from time to time and the most recent guidelines have been proposed by the American Heart Association (AHA) in 2017. However, several children may have incomplete or atypical forms of KD and the diagnosis can often be difficult, especially in infants and young children...
November 13, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29129563/da-raf-a-dominant-negative-antagonist-of-the-ras-erk-pathway-is-a-putative-tumor-suppressor
#12
Emiri Kanno, Osamu Kawasaki, Kazuya Takahashi, Kazunori Takano, Takeshi Endo
Activating mutations of RAS genes, particularly KRAS, are detected with high frequency in human tumors. Mutated Ras proteins constitutively activate the ERK pathway (Raf-MEK-ERK phosphorylation cascade), leading to cellular transformation and tumorigenesis. DA-Raf1 (DA-Raf) is a splicing variant of A-Raf and contains the Ras-binding domain (RBD) but lacks the kinase domain. Accordingly, DA-Raf antagonizes the Ras-ERK pathway in a dominant-negative fashion and suppresses constitutively activated K-Ras-induced cellular transformation...
November 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29128693/effect-of-adding-support-structures-for-overhanging-part-on-fatigue-strength-in-selective-laser-melting
#13
Yuka Kajima, Atsushi Takaichi, Takayuki Nakamoto, Takahiro Kimura, Nuttaphon Kittikundecha, Yusuke Tsutsumi, Naoyuki Nomura, Akira Kawasaki, Hidekazu Takahashi, Takao Hanawa, Noriyuki Wakabayashi
Selective laser melting (SLM) technology was recently introduced to fabricate dental prostheses. However, the fatigue strength of clasps in removable partial dentures prepared by SLM still requires improvement. In this study, we attempted to improve the fatigue strength of clasps by adding support structures for overhanging parts, which can generally be manufactured at an angle to be self-supporting. The results show that the fatigue strength of the supported specimens was more than twice that of unsupported specimens...
November 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29127646/can-we-spice-up-our-christmas-dinner-busting-the-myth-of-the-chinese-restaurant-syndrome
#14
N W E van den Berg, J Neefs, W R Berger, S W E Baalman, E Meulendijks, M Kawasaki, E M Kemper, F R Piersma, M W Veldkamp, R Wesselink, S P J Krul, J R de Groot
BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF. METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam...
November 10, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29125092/monitoring-the-south-african-population-s-salt-intake-spot-urine-v-24-h-urine
#15
Bianca Swanepoel, Aletta E Schutte, Marike Cockeran, Krisela Steyn, Edelweiss Wentzel-Viljoen
OBJECTIVE: The present study set out to determine whether morning spot urine samples can be used to monitor Na (and K) intake levels in South Africa, instead of the 'gold standard' 24 h urine sample. DESIGN: Participants collected one 24 h and one spot urine sample for Na and K analysis, after which estimations using three different formulas (Kawasaki, Tanaka and INTERSALT) were calculated. SETTING: Between 2013 and 2015, urine samples were collected from different population groups in South Africa...
November 10, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29123980/dynamic-integration-and-excision-of-filamentous-phage-xacf1-in-xanthomonas-citri-pv-citri-the-causative-agent-of-citrus-canker-disease
#16
Abdelmonim A Ahmad, Makoto Kawabe, Ahmed Askora, Takeru Kawasaki, Makoto Fujie, Takashi Yamada
Inovirus XacF1 (7325 nucleotides) is integrated into the genome of Xanthomonas citri pv. citri (Xcc) strains at the host dif site (attB) by the host XerC/D recombination system. The XacF1 attP sequence is located within the coding region of ORF12, a possible phage regulator. After integration, this open reading frame (ORF) is split into two pieces on the host genome. We examined dynamic integration/excision of XacF1 in Xcc strain MAFF 301080 and found that the integration started at 4 h postinfection (p.i.) and peaked at 12 h p...
November 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29123859/non-traumatic-bladder-rupture-showing-less-than-10-hounsfield-units-of-ascites
#17
Naoto Mizumura, Satoshi Okumura, Sho Toyoda, Atsuo Imagawa, Masao Ogawa, Masayasu Kawasaki
Aim: Bladder ruptures are commonly misdiagnosed as gastrointestinal perforations or intestinal ischemia. If a diagnosis is made preoperatively, conservative treatment is a safe and effective option. We evaluated the validity of using the attenuation value of ascites, measured by non-contrast computed tomography (CT), to identify patients with bladder ruptures. Methods: A retrospective search of our hospital database identified 7 patients with confirmed bladder ruptures between 2007 and 2013...
April 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29123838/prehospital-triage-for-endovascular-clot-removal-in-acute-stroke-patients
#18
Yu Suzuki, Yasuhiro Hasegawa, Kohtaro Tsumura, Toshihiro Ueda, Kazunari Suzuki, Makoto Sugiyama, Hiroyuki Nozaki, Shojiro Kawaguchi, Makoto Nakane, Goro Nagashima, Takayuki Kitamura, Kengo Yokomine, Jinichi Sasanuma
Aim: To establish prehospital triage in accordance with the new guidelines for endovascular therapy, we retrospectively analyzed the monitoring data of the city-wide transportation system using the Maria Prehospital Stroke Scale (MPSS), a novel prehospital stroke scale for emergency medical technicians (EMTs) to predict the likelihood of thrombolytic therapy after transportation. Methods: Kawasaki City, Japan, has six comprehensive stroke centers (CSCs) and six primary stroke centers (PSCs)...
January 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122906/safety-netting-versus-overtreatment-in-paediatrics-viral-infection-or-incomplete-kawasaki-disease
#19
Jennifer Michelle Charlesworth, Bernadette Power, Edina Moylett
Kawasaki disease (KD) is the most common systemic vasculitis of childhood. The following presentation of a 4-year-old Irish boy referred to a secondary care paediatric service from the community with prolonged fever, oral mucous membrane changes and painless blistering lesions of the hands and feet in the presence of elevated inflammatory markers serves as an opportunity to discuss the diagnostic criteria and treatment for KD and incomplete KD, an often missed diagnosis with significant paediatric morbidity outside an academic paediatric centre...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29120960/external-validation-and-comparison-of-formulae-estimating-24-h-sodium-intake-from-a-fasting-morning-urine-sample
#20
Emmanuelle Vidal-Petiot, Adrien Joseph, Matthieu Resche-Rigon, Anne Boutten, Jimmy Mullaert, Marie-Pia d' Ortho, François Vrtovsnik, Ph Gabriel Steg, Martin Flamant
OBJECTIVE: The relationship between sodium intake and cardiovascular events is controversial, but most large epidemiological studies estimated sodium intake using formulae based on single urine samples, the validity of which is debated. We evaluated sodium intake estimating formulae in a large cohort of adult patients. DESIGN AND METHODS: Patients were asked to collect 24-h urine the day before admission. Validity of the 24-h urine collection was assessed by comparing creatinine clearance from this collection to the mean creatinine clearance from six fractionated urine samples...
November 7, 2017: Journal of Hypertension
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