keyword
MENU ▼
Read by QxMD icon Read
search

Kawasaki

keyword
https://www.readbyqxmd.com/read/29773519/the-neurosteroid-allopregnanolone-sulfate-inhibits-na-v-1-3-%C3%AE-subunit-containing-voltage-gated-sodium-channels-expressed-in-xenopus-oocytes
#1
Takafumi Horishita, Nobuyuki Yanagihara, Susumu Ueno, Dan Okura, Reiko Horishita, Tomoko Minami, Yuichi Ogata, Yuka Sudo, Yasuhito Uezono, Takashi Kawasaki
The neurosteroid allopregnanolone has potent analgesic effects, and its potential use for neuropathic pain is supported by recent reports. However, the analgesic mechanisms are obscure. The voltage-gated sodium channels (Nav ) α subunit Nav 1.3 is thought to play an essential role in neuropathic pain. Here, we report the effects of allopregnanolone sulfate (APAS) on sodium currents (INa ) in Xenopus oocytes expressing Nav 1.3 with β1 or β3 subunits. APAS suppressed INa of Nav 1.3 with β1 and β3 in a concentration-dependent manner (IC50 values; 75 and 26 μmol/L)...
March 30, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29772369/sciatic-neuralgia-caused-by-may-thurner-syndrome-case-report
#2
Kazuaki Yamamoto, Gakuji Gondo, Hidemitsu Ogino, Tsuyoshi Watanabe, Masahiko Tanaka, Satoshi Tanaka, Taisuke Kawasaki
BACKGROUND: Sciatic neuralgia (SN) is a type of pain commonly associated with lumbosacral radiculopathy. May-Thurner syndrome (MTS) is a disease characterized by venous congestion in the left common iliac vein (LCIV) due to right common iliac artery compression. In this report, the authors describe a case of MTS with SN as the first presenting symptom. CASE DESCRIPTION: A 53-year-old man gradually developed left SN; however, radiological examination showed no causal findings...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771771/a-therapeutic-strategy-for-resectable-pancreatic-cancer-based-on-risk-factors-of-early-recurrence
#3
Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Takaaki Arigami, Shinichiro Mori, Yuko Kijima, Shinichi Ueno, Hiroyuki Shinchi, Shoji Natsugoe
OBJECTIVES: The aim of this study was to identify risk factors for early recurrence and assess the prognostic benefit of neoadjuvant therapy (NAT) for resectable pancreatic cancer. METHODS: Patients with radiographically resectable pancreatic cancer according to the National Comprehensive Cancer Network guidelines were enrolled. We regarded recurrence within 6 months after surgery as early recurrence. RESULTS: This study involved 115 patients (80 who underwent upfront surgery and 35 who received NAT)...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29771320/immunoglobulin-profiling-identifies-unique-signatures-in-patients-with-kawasaki-disease-during-intravenous-immunoglobulin-treatment
#4
Tai-Ming Ko, Kazuma Kiyotani, Jeng-Sheng Chang, Jae-Hyun Park, Poh Yin Yew, Yuan-Tsong Chen, Jer-Yuarn Wu, Yusuke Nakamura
Identifying the causes of high fever syndromes such as Kawasaki disease (KD) remains challenging. To investigate pathogen exposure signatures in suspected pathogen-mediated diseases like KD, we performed immunoglobulin (Ig) profiling using a next-generation sequencing method. After intravenous Ig (IVIG) treatment, we observed disappearance of clonally expanded IgM clonotypes, which were dominantly observed in acute-phase patients. The complementary-determining region 3 (CDR3) sequences of dominant IgM clonotypes in acute-phase patients were commonly observed in other Ig isotypes...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29769630/locally-induced-neuronal-synchrony-precisely-propagates-to-specific-cortical-areas-without-rhythm-distortion
#5
Haruo Toda, Keisuke Kawasaki, Sho Sato, Masao Horie, Kiyoshi Nakahara, Asim K Bepari, Hirohito Sawahata, Takafumi Suzuki, Haruo Okado, Hirohide Takebayashi, Isao Hasegawa
Propagation of oscillatory spike firing activity at specific frequencies plays an important role in distributed cortical networks. However, there is limited evidence for how such frequency-specific signals are induced or how the signal spectra of the propagating signals are modulated during across-layer (radial) and inter-areal (tangential) neuronal interactions. To directly evaluate the direction specificity of spectral changes in a spiking cortical network, we selectively photostimulated infragranular excitatory neurons in the rat primary visual cortex (V1) at a supra-threshold level with various frequencies, and recorded local field potentials (LFPs) at the infragranular stimulation site, the cortical surface site immediately above the stimulation site in V1, and cortical surface sites outside V1...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768976/predictors-of-intravenous-immunoglobulin-resistance-and-coronary-artery-aneurysm-in-patients-with-kawasaki-disease
#6
Nattika Chantasiriwan, Suchaya Silvilairat, Krit Makonkawkeyoon, Yupada Pongprot, Rekwan Sittiwangkul
BACKGROUND: Patients with Kawasaki disease (KD) who have intravenous immunoglobulin (IVIG) resistance are at increased risk for development of coronary artery abnormalities. Although in Japan several risk scoring systems are able to predict patients with IVIG-resistant (KD), they do not accurately predict non-responders in other regions. AIM: The objectives of this study were to determine the predictors of IVIG resistance and coronary artery aneurysm (CAA) and to develop risk scoring systems for predicting IVIG-resistant KD in the Thai population...
May 17, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29765083/adeno-associated-virus-vector-mediated-interleukin-10-induction-prevents-vascular-inflammation-in-a-murine-model-of-kawasaki-disease
#7
Jun Nakamura, Sachiko Watanabe, Hiroaki Kimura, Motoi Kobayashi, Tadayoshi Karasawa, Ryo Kamata, Fumitake Usui-Kawanishi, Ai Sadatomo, Hiroaki Mizukami, Noriko Nagi-Miura, Naohito Ohno, Tadashi Kasahara, Seiji Minota, Masafumi Takahashi
Kawasaki disease (KD), which is the leading cause of pediatric heart disease, is characterized by coronary vasculitis and subsequent aneurysm formation. Although intravenous immunoglobulin therapy is effective for reducing aneurysm formation, a certain number of patients are resistant to this therapy. Because interleukin-10 (IL-10) was identified as a negative regulator of cardiac inflammation in a murine model of KD induced by Candida albicans water-soluble fraction (CAWS), we investigated the effect of IL-10 supplementation in CAWS-induced vasculitis...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760310/cannon-sounds
#8
Kuniyasu Harimoto, Tatsuya Kawasaki, Tadaaki Kamitani
No abstract text is available yet for this article.
May 11, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29757602/visualization-of-electronic-multiple-ordering-emo-and-its-dynamics-in-high-magnetic-field-evidence-of-emo-crystals
#9
Zhigao Sheng, Qiyuan Feng, Haibiao Zhou, Shuai Dong, Xueli Xu, Long Cheng, Caixing Liu, Yubin Hou, Wenjie Meng, Yuping Sun, Masao Nakamura, Yoshinori Tokura, Masashi Kawasaki, Qingyou Lu
Constituent atoms and electrons determine matter properties together and they can form long-range ordering respectively. Distinguishing and isolating the electronic ordering out from the lattice crystal is a crucial issue in contemporary materials science. However, the intrinsic structure of a long-range electronic ordering is difficult to observe because it can be easily affected by many external factors. Here, we present the observation of electronic multiple ordering (EMO) and its dynamics at the micrometer scale in a manganite thin film...
May 14, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29756424/incomplete-kawasaki-disease-with-coronary-aneurysms-in-a-young-infant-of-45-days-presented-as-neonatal-sepsis
#10
K Dayasiri, A Kariyawasam, R Dissanayaka, D Samarasinghe, H De Silva
No abstract text is available yet for this article.
March 31, 2018: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29756018/a-structured-light-laser-probe-for-gastrointestinal-polyp-size-measurement-a-preliminary-comparative-study
#11
Marco Visentini-Scarzanella, Hiroshi Kawasaki, Ryo Furukawa, Marco Augusto Bonino, Simone Arolfo, Giacomo Lo Secco, Alberto Arezzo, Arianna Menciassi, Paolo Dario, Gastone Ciuti
Background and study aims:  Polyp size measurement is an important diagnostic step during gastrointestinal endoscopy, and is mainly performed by visual inspection. However, lack of depth perception and objective reference points are acknowledged factors contributing to measurement errors in polyp size. In this paper, we describe the proof-of-concept of a polyp measurement device based on structured light technology for future endoscopes. Patients and methods:  Measurement accuracy, time, user confidence, and satisfaction were evaluated for polyp size assessment by (a) visual inspection, (b) open biopsy forceps of known size, (c) ruled snare, and (d) structured light probe, for a total of 392 independent polyp measurements in ex vivo porcine stomachs...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29755710/laboratory-biomarkers-to-facilitate-differential-diagnosis-between-measles-and-kawasaki-disease-in-a-pediatric-emergency-room-a-retrospective-study
#12
Danilo Buonsenso, Giulia Macchiarulo, Maria Chiara Supino, Francesco La Penna, Simona Scateni, Alessandra Marchesi, Antonino Reale, Elena Boccuzzi
This retrospective study was conducted to analyze clinical and laboratoristic parameters to individuate specific differences and facilitate differential diagnosis between Measles and Kawasaki Disease (KD) at first evaluation in an emergency room. We found similar clinical features as duration of fever and number of KD criteria (p > 0.5) but significant differences in white blood cell count, neutrophils, CRP and LDH levels (p < 0.001). LDH value ≥ 800 mg/dl had sensibility of 89% and specificity of 90% for Measles while CRP ≥ 3 mg/dl had sensibility 89% and specificity of 85% for KD...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29755089/-surgical-repair-of-kommerell-s-diverticulum-with-right-sided-aortic-arch-report-of-a-case
#13
Hiromitsu Kawasaki, Yoshihiro Nakayama, Yuichi Koga, Baku Takahashi, Hisashi Sato
A 54-year-old woman was referred for assessment of dysphagia and extrinsic compression of the esophagus detected by upper gastrointestinal endoscopy. Computed tomography revealed the rightsided aortic arch with mirror image branching and Kommerell's diverticulum. To relieve the esophageal compression, surgical intervention was indicated. Descending aortic replacement with a Dacron graft was performed through right thoracotomy under partial cardiopulmonary bypass. The patient was discharged without any complication, and her dysphagia disappeared...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29755077/-left-atrial-myxoma-with-ossification-report-of-a-case
#14
Hiroaki Hagiwara, Tomohiro Nakayama, Tomonori Kawasaki
A 69-year-old female with left atrial tumor was refered to our hospital for surgical treatment. The tumor was attached to the interatrial septum and resected completely. Histopathological analysis confirmed a myxoma with ossification(mature bone). These findings may support the hypothesis that the undifferentiated mesenchymal cells are the origin of cardiac myxoma.
March 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29753903/detection-of-nineteen-enteric-viruses-in-raw-sewage-in-japan
#15
Aksara Thongprachum, Tsuguto Fujimoto, Sayaka Takanashi, Hiroyuki Saito, Shoko Okitsu, Hiroyuki Shimizu, Pattara Khamrin, Niwat Maneekarn, Satoshi Hayakawa, Hiroshi Ushijima
One-year surveillance for enteric viruses in raw sewage was conducted in Kansai area, central part of Japan from July 2015 to June 2016. The raw sewage was collected monthly from an inlet polluted pool and was concentrated by polyethylene glycol (PEG) precipitation. Twelve sewage samples were screened for nineteen kinds of enteric viruses by using RT-PCR method and further analyzed by nucleotide sequencing. Twelve enteric viruses were found in the investigative sewage samples. Rotavirus A and norovirus GI and GII with several genotypes were detected all year round...
May 10, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29749135/variants-in-the-gene-ebf2-are-associated-with-kawasaki-disease-in-a-korean-population
#16
Yoonsun Bae, Dongjik Shin, Jiho Nam, Hye Rim Lee, Jun Sung Kim, Kyu Yeun Kim, Dong Soo Kim, Yeun Jun Chung
PURPOSE: Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. MATERIALS AND METHODS: An SNP analysis was performed by whole exon sequencing of the EBF2 gene...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29747485/sudden-child-death-due-to-thrombotic-giant-coronary-artery-aneurysms-complicated-by-atypical-kawasaki-disease-an-autopsy-case
#17
DongJa Kim, Man-Hoon Han, SangHan Lee
No abstract text is available yet for this article.
May 11, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29745742/delayed-intravenous-immunoglobulin-treatment-increased-the-risk-of-coronary-artery-lesions-in-children-with-kawasaki-disease-at-different-status
#18
Huixian Qiu, Yuee He, Xing Rong, Yue Ren, Lulu Pan, Maoping Chu, Rongzhou Wu, Hongying Shi
OBJECTIVE: Kawasaki disease (KD) is a systemic vasculitis with serious complications, especially the development of coronary artery lesions (CALs). The aim of this study was to identify the risk for the development of CALs with IVIG treatment of KD >10 days after illness onset in patients with different KD status, and explore potential moderators of the association between delayed treatment and CALs. METHODS: We performed a retrospective review of the medical records of KD patients...
May 10, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29742664/surgical-alteration-of-genital-hiatus-size-and-anatomic-failure-after-vaginal-vault-suspension
#19
Monique H Vaughan, Nazema Y Siddiqui, Laura K Newcomb, Alison C Weidner, Amie Kawasaki, Anthony G Visco, Megan S Bradley
OBJECTIVE: To compare anatomic outcomes after native tissue vaginal vault suspension among women categorized by their preoperative and 6-week postoperative genital hiatus size. METHODS: We performed a retrospective cohort study in women who underwent native tissue vaginal vault suspension between 2005 and 2015. We defined a wide genital hiatus as 4 cm or greater and a normal genital hiatus as less than 4 cm. We compared three groups: 1) women with a wide genital hiatus preoperatively and 6 weeks postoperatively (persistently wide group), 2) women with a wide genital hiatus preoperatively but normal genital hiatus 6 weeks postoperatively (improved group), and 3) women with a normal genital hiatus preoperatively and 6 weeks postoperatively (stably normal group)...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742650/murine-typhus-mimicking-kawasaki-disease-in-a-pre-adolescent-girl
#20
Maria A Karalexi, Marina Mitrogiorgou, Erato Atsali, Antonios Theodorakopoulos, Achilleas Attilakos, Vasileios Tsagris
We report the case of an 11-year-old pre-adolescent girl presenting with prolonged fever, lymphadenitis, non-purulent conjuctivitis, a generalized maculopapular rash, erythematous lips and edema of hands/feet. Although major diagnostic criteria for Kawasaki disease were met, local epidemiologic data suggested a possible vector-borne etiology. Treatment with doxycycline was initiated and defervescence occurred. Laboratory investigation confirmed the diagnosis of Rikettsia typhi infection.
May 4, 2018: Pediatric Infectious Disease Journal
keyword
keyword
29786
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"