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https://www.readbyqxmd.com/read/28526535/tnf-%C3%AE-is-superior-to-conventional-inflammatory-mediators-in-forecasting-ivig-nonresponse-and-coronary-arteritis-in-chinese-children-with-kawasaki-disease
#1
Peng Hu, Guang Mei Jiang, Yue Wu, Bao Yu Huang, Si Yan Liu, Dong Dong Zhang, Yao Xu, Yang Fang Wu, Xun Xia, Wei Wei, Bo Hu
BACKGROUND: Tumor necrosis factor (TNF) -α is of inflammatory cytokines produced chiefly by activated monocyte/macrophages, and has been implicated in the pathogenesis of Kawasaki disease (KD). We elucidated the relationship of plasma TNF-α with conventional inflammatory mediators, clinical classification, intravenous immunoglobulin (IVIG) response and coronary arteritis in the course of KD. METHODS: Seventy Chinese children with KD were enrolled and divided into 6 subgroups, including complete KD, incomplete KD, IVIG-responsive KD, IVIG-nonresponsive KD, coronary artery (CA) -noninvolvement KD and CA-involvement KD...
May 16, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28525643/synthetic-mrna-devices-that-detect-endogenous-proteins-and-distinguish-mammalian-cells
#2
Shunsuke Kawasaki, Yoshihiko Fujita, Takashi Nagaike, Kozo Tomita, Hirohide Saito
Synthetic biology has great potential for future therapeutic applications including autonomous cell programming through the detection of protein signals and the production of desired outputs. Synthetic RNA devices are promising for this purpose. However, the number of available devices is limited due to the difficulty in the detection of endogenous proteins within a cell. Here, we show a strategy to construct synthetic mRNA devices that detect endogenous proteins in living cells, control translation and distinguish cell types...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28524187/a-designer-ligand-field-for-blue-green-luminescence-of-organoeuropium-ii-sandwich-complexes-with-cyclononatetraenyl-ligands
#3
Kenshiro Kawasaki, Rion Sugiyama, Takashi Tsuji, Takeshi Iwasa, Hironori Tsunoyama, Yoshiyuki Mizuhata, Norihiro Tokitoh, Atsushi Nakajima
A novel η(9)-coordinated double-decker sandwich complex of divalent europium is synthesized. The complex exhibits blue-green photoluminescence at 516 nm, which is significantly blue-shifted from those of other organoeuropium(ii) sandwich complexes (∼630 nm). The blue-shift was quantitatively explained by the weakened electrostatic field of the expanded 10-π ring.
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28523571/congenital-immature-pure-erythroid-leukemia-with-e-cadherin-expression
#4
Akihiro Tamura, Suguru Uemura, Atsuro Saito, Saki Okubo, Nanako Nino, Teppei Tahara, Takehito Yokoi, Kenji Kishimoto, Toshiaki Ishida, Daiichiro Hasegawa, Keiichiro Kawasaki, Seiji Yoshimoto, Hideto Nakao, Makiko Yoshida, Yoshiyuki Kosaka
Congenital pure erythroid leukemia is exceedingly rare and poses a diagnostic challenge. We report an atypical case of congenital pure erythroid leukemia that did not express typical erythroid markers. The patient presented with a high white blood cell count with blastic cells at birth. Although flow cytometric analyses of peripheral blood and bone marrow showed a large CD45-negative cell population, we did not identify any evidence of monoclonality. While the circulating blasts decreased with only supportive care, hepatomegaly with multiple nodules was accompanied by liver failure, disseminated intravascular coagulation, and development of hemophagocytic lymphohistiocytosis...
May 18, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28522874/calcium-deficient-hydroxyapatite-as-a-potential-sorbent-for-strontium
#5
Yurina Sekine, Ryuhei Motokawa, Naofumi Kozai, Toshihiko Ohnuki, Daiju Matsumura, Takuya Tsuji, Riku Kawasaki, Kazunari Akiyoshi
A calcium (Ca)-deficient hydroxyapatite was investigated for its potential to remove Sr(2+) from environmentally relevant water. We conducted sorption tests on solutions containing magnesium ion (Mg(2+)) and calcium ion (Ca(2+)) as competing cations at a strontium ion (Sr(2+)) concentration of 0.05 mmol/L. The Ca-deficient hydroxyapatite maintained a high Sr(2+) sorption ratio of above 80% in the presence of Mg(2+) and Ca(2+) at the concentrations between 0.1 and 1.0 mmol/L, whereas the stoichiometric hydroxyapatite showed a lower ratio even in the presence of small amounts of Mg(2+) and Ca(2+) (72% for Mg(2+) and 51% for Ca(2+) at 0...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28516913/self-folding-origami-at-any-energy-scale
#6
Matthew B Pinson, Menachem Stern, Alexandra Carruthers Ferrero, Thomas A Witten, Elizabeth Chen, Arvind Murugan
Programmable stiff sheets with a single low-energy folding motion have been sought in fields ranging from the ancient art of origami to modern meta-materials research. Despite such attention, only two extreme classes of crease patterns are usually studied; special Miura-Ori-based zero-energy patterns, in which crease folding requires no sheet bending, and random patterns with high-energy folding, in which the sheet bends as much as creases fold. We present a physical approach that allows systematic exploration of the entire space of crease patterns as a function of the folding energy...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28515407/comparison-of-the-outback-%C3%A2-elite-reentry-catheter-and-the-bi-directional-approach-after-failed-antegrade-approach-for-femoro-popliteal-occlusive-disease
#7
Daizo Kawasaki, Masashi Fukunaga, Tsuyoshi Nakata, Masaaki Kato, Nobukazu Ohkubo
AIM: A successful antegrade wire crossing for femoro-popliteal chronic total occlusion (FP-CTO) is still a technical challenge. We attempted to demonstrate the safety and feasibility of the OUTBACK(®) Elite reentry catheter and the bi-directional approach for failed FP-CTO cases with the antegrade approach. METHODS: Endovascular therapy for FP-CTO was performed in 219 lesions from May 2013 to December 2016 at Morinomiya Hospital. We retrospectively analyzed the data of 43 consecutive lesions which underwent endovascular therapy using the bi-directional approach with distal access and the mono-directional approach with the OUTBACK(®) Elite reentry catheter for FP-CTO lesions...
May 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28514726/retrospective-analysis-of-risk-factors-associated-with-kawasaki-disease-in-china
#8
Lihua Bai, Tienan Feng, Lifang Yang, Yi Zhang, Xuejuan Jiang, Jiayao Liao, Lihua Chen, Xiaoyan Feng, Yanming Rong, Yuehua Li, Zhiqiang Qin, Jing Qiao
In order to provide early intervention for coronary artery lesion (CAL) caused by Kawasaki Disease (KD), we analyzed clinical characteristics of typical and incomplete KD cases from 1998 to 2008 in Northwest and Central China. A total of 383 patients included 298 cases of typical KD and 85 cases of incomplete KD. The morbidity of incomplete KD was 28.5%, a percentage significantly lower than that of typical KD. The occurrence of bulbar conjunctiva congestion, erythra, crissum red, film-like decrustation, lip red, rhagades, raspberry tongue, bilateral toe-end decrustation, limb sclerosis, cervical lymph nodes enlargement, agitation and irritability in incomplete KD group was lower than that in the group of typical KD (p < 0...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512721/mid-term-risk-for-subclinical-atherosclerosis-and-chronic-myocarditis-in-children-with-kawasaki-disease-and-transient-coronary-abnormalities
#9
Mansingh Parihar, Surjit Singh, Pandiarajan Vignesh, Anju Gupta, Manojkumar Rohit
There is evidence for premature atherosclerosis and systemic arterial stiffening during follow-up of children with Kawasaki disease (KD) and coronary artery abnormalities (CAA). Moreover, patients with KD may also have subclinical myocardial involvement and inhomogeneous ventricular repolarization. The inhomogeneous ventricular repolarization manifests as increased QT dispersion on electrocardiography. There is a paucity of studies in endothelial dysfunction and QT dispersion in children with KD and transient CAA...
May 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28512385/association-of-pecam-1-gene-polymorphisms-with-kawasaki-disease-in-chinese-children
#10
Zhuoying Li, Dong Han, Jie Jiang, Jia Chen, Lang Tian, Zuocheng Yang
Kawasaki disease (KD) is an acute systemic vasculitis complicated by development of coronary artery lesions. PECAM-1 is a kind of cell adhesion molecule, which plays an important role in coronary artery disease. The relationship between PECAM-1 gene polymorphisms and their susceptibility to Kawasaki diseases (KD) is still unclear. In our study, we examined the PECAM-1 gene polymorphisms in 44 KD patients and 59 healthy children and revealed the correlation of PECAM-1 gene polymorphisms in KD children with and without coronary artery lesions (CAL)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28511980/reward-loss-and-the-basolateral-amygdala-a-function-in-reward-comparisons
#11
Katsuyoshi Kawasaki, Iván Annicchiarico, Amanda C Glueck, Ignacio Morón, Mauricio R Papini
The neural circuitry underlying behavior in reward loss situations is poorly understood. We considered two such situations: reward devaluation (from large to small rewards) and reward omission (from large rewards to no rewards). There is evidence that the central nucleus of the amygdala (CeA) plays a role in the negative emotion accompanying reward loss. However, little is known about the function of the basolateral nucleus (BLA) in reward loss. Two hypotheses of BLA function in reward loss, negative emotion and reward comparisons, were tested in an experiment involving pretraining excitotoxic BLA lesions followed by training in four tasks: consummatory successive negative contrast (cSNC), autoshaping (AS) acquisition and extinction, anticipatory negative contrast (ANC), and open field testing (OF)...
May 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28511718/simultaneous-development-of-kawasaki-disease-following-acute-human-adenovirus-infection-in-monozygotic-twins-a-case-report
#12
Sayaka Fukuda, Shuichi Ito, Maya Fujiwara, Jun Abe, Nozomu Hanaoka, Tsuguto Fujimoto, Hiroshi Katsumori
BACKGROUND: The etiology of Kawasaki disease (KD) remains unknown. However, many studies have suggested that specific genetic factors and/or some infectious agents underlie the onset of KD. Previous studies have suggested that human adenovirus (HAdV) is one of the triggering pathogens of KD. Here, we report monozygotic twin boys who sequentially developed KD in conjunction with acute HAdV type 3 (HAdV-3) infection. CASE PRESENTATION: The patients were four-year-old monozygotic twin boys...
May 16, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28508981/partial-remission-by-cyclosporine-monotherapy-in-a-patient-with-membranous-nephropathy-superimposed-diabetic-nephropathy
#13
Yoshiyuki Oshiro, Hisataka Tanaka, Fumiko Kawasaki, Niro Okimoto
It has been noted that cyclosporine A (CsA) is an effective drug for membranous nephropathy (MN). Diabetes is a common disease that sometimes causes nephrotic syndrome. We report the case of an 89-year-old woman with type 2 diabetes mellitus who exhibited nephrotic syndrome. Examination of a renal biopsy indicated MN and she was prescribed CsA as monotherapy. Her edema subsided and she achieved partial remission. This is the first report of a patient in diabetic condition with MN having achieved partial remission after CsA monotherapy without steroid therapy...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28508228/relationship-between-white-blood-cell-count-elevation-and-clinical-response-after-g-csf-priming-chemotherapy-for-acute-myeloid-leukemia
#14
Daisuke Minakata, Shin-Ichiro Fujiwara, Takashi Ikeda, Yumiko Toda, Shoko Ito, Kiyomi Mashima, Kento Umino, Hirofumi Nakano, Ryoko Yamasaki, Kaoru Morita, Yasufumi Kawasaki, Miyuki Sugimoto, Chihiro Yamamoto, Masahiro Ashizawa, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine, Kazuo Muroi, Yoshinobu Kanda
We retrospectively analyzed the relationship between white blood cell (WBC) count elevation after priming and clinical response in 115 patients with AML (61 untreated and 54 relapsed or refractory) treated with low-dose cytarabine, aclarubicin, and G-CSF priming. Receiver operating characteristic curve analysis showed that the ratio of maximum WBC count to pretreatment WBC count (WBCratio) was most strongly associated with complete remission (CR) in previously untreated patients among several parameters we analyzed in this study; however, the prediction accuracy was not clinically significant considering the area under the curve of 0...
May 15, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28505365/allograft-inflammatory-factor-1-links-t-cell-activation-interferon-response-and-macrophage-activation-in-chronic-kawasaki-disease-arteritis
#15
Anne H Rowley, Susan C Baker, Kwang-Youn A Kim, Stanford T Shulman, Amy Yang, David Arrollo, Matthew DeBerge, Shuling Han, Nicholas E S Sibinga, Adam J Pink, Edward B Thorp
Background.: Kawasaki disease (KD) is widely viewed as an acute arteritis. However, our pathologic studies show that chronic coronary arteritis can persist long after disease onset and is closely linked with arterial stenosis. Transcriptome profiling of acute KD arteritis tissues revealed upregulation of T lymphocyte, type I interferon, and allograft inflammatory factor-1 (AIF1) genes. We determined whether these immune responses persist in chronic KD arteritis, and we investigated the role of AIF1 in these responses...
May 15, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28503322/changes-in-oxidized-ldl-during-a-half-marathon-in-athletes-with-spinal-cord-injuries
#16
Toshihito Mitsui, Tomoyuki Ito, Yusuke Sasaki, Takashi Kawasaki, Takeshi Nakamura, Yukihide Nishimura, Tatsuru Ibusuki, Yukiharu Higuchi, Sayoko Hosoe, Fumiaki Ito, Fumihiro Tajima
INTRODUCTION: We reported previously that exercise significantly increases plasma adrenaline and oxidized low-density lipoprotein (oxLDL) in healthy subjects but not in persons with spinal cord injury (SCI). Since oxLDL and adrenaline levels are associated with oxidant/antioxidant balance, and exercise training elicits production of reactive oxygen species, we elucidated the effects of exercise on adrenaline, oxidant/antioxidant balance and oxLDL in individuals with SCI. CASE PRESENTATION: Eight subjects with cervical spinal cord injury (CSCI) and nine subjects with lower lesion of SCI (lower SCI (LSCI)) participated in a wheelchair half marathon race, and blood samples were collected before (pre), immediately after (post) and 1 h after the race (post 1 h)...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28502932/rhabdomyolysis-after-high-intensity-resistance-training
#17
Sakiko Honda, Tatsuya Kawasaki, Tadaaki Kamitani, Keisuke Kiyota
Rhabdomyolysis, which is a characteristic occurrence in associated with muscle cell necrosis, develops due to various causes. We herein report a rare case of a patient with rhabdomyolysis after high intensity resistance training, in which markedly elevated levels of serum creatine kinase (CK) and urine myoglobin were observed. A previously healthy 37-year-old man presented with severe myalgia and dark urine after performing high-intensity exercise. The patient's serum CK level was 95,100 U/L and his urine myoglobin level was 160,000 ng/mL...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28500540/prediction-of-sudden-cardiac-death-in-patients-with-chronic-heart-failure-by-regional-washout-rate-in-cardiac-mibg-spect-imaging
#18
Hironori Yamamoto, Takahisa Yamada, Shunsuke Tamaki, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tatsuhisa Ozaki, Masahiro Seo, Yoshihiro Sato, Iyo Ikeda, Eiji Fukuhara, Makoto Abe, Jun Nakamura, Masatake Fukunami
BACKGROUND: The sympathetic nervous system provides an important trigger for major arrhythmic events through regional heterogeneity of sympathetic activity, which could be evaluated by SPECT imaging as the regional MIBG washout rate (WR). There is little information available on the prognostic value of regional WR in SPECT imaging for the prediction of sudden cardiac death (SCD) in patients with chronic heart failure (CHF). METHODS: We studied 73 CHF outpatients with LVEF < 40%...
May 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28498302/reaction-of-the-bcg-scar-in-the-acute-phase-of-kawasaki-disease-in-mexican-children
#19
Luis Martín Garrido-García, Ariel Castillo-Moguel, Mirell Vázquez-Rivera, Patricia Cravioto, Galván Fernando
BACKGROUND: Kawasaki disease is an acute self-limited systemic vasculitis that primarily affects children < 5 years old. There is no specific diagnostic test. A reaction at the Bacille Calmette-Guérin inoculation site has been reported as a common finding in patients with Kawasaki disease where BCG vaccination is mandatory. The purpose of this study was to evaluate the frequency of reactivation of the BCG in Mexican children diagnosed with Kawasaki disease. METHODS: A retrospective study of all patients diagnosed with Kawasaki disease from August 1 1995 to August 31 2015 at our Institution was performed...
May 11, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28496051/molecular-investigations-of-development-and-diseases-of-the-brain-of-higher-mammals-using-the-ferret
#20
Hiroshi Kawasaki
The brains of higher mammals such as primates and carnivores contain well-developed unique brain structures. Uncovering the physiological functions, developmental mechanisms and evolution of these brain structures would greatly facilitate our understanding of the human brain and its diseases. Although the anatomical and electrophysiological features of these brain structures have been intensively investigated, our knowledge about their molecular bases is still limited. To overcome this limitation, genetic techniques for the brains of carnivores and primates have been established, and molecules whose expression patterns correspond to these brain structures were identified recently...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
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