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https://www.readbyqxmd.com/read/28646712/prediction-of-vocational-participation-and-global-role-functioning-in-help-seeking-young-adults-from-neurocognitive-demographic-and-clinical-variables
#1
Alice J Cairns, David J Kavanagh, Frances Dark, Steven M McPhail
BACKGROUND: The purpose of this study was to investigate neurocognitive, demographic and clinical correlates of vocational participation among a sample of young help-seeking adults. METHODS: Young people (18-25 years) accessing an early intervention youth health service participated. The Global Functioning: Role scale and level of vocational participation, participant characteristics (age, gender, socioeconomic background and family history of serious mental illness), distress, psychotic-like experiences, substance use, and mental health diagnoses were recorded...
June 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28646446/innovations-in-the-endovascular-management-of-critical-limb-ischemia-retrograde-tibiopedal-access-and-advanced-percutaneous-techniques
#2
REVIEW
Jihad A Mustapha, Larry J Diaz-Sandoval, Fadi Saab
PURPOSE OF REVIEW: Retrograde tibiopedal access and interventions have contributed to advance of endovascular techniques to treat critical limb ischemia (CLI) patients. This review encompasses the spectrum from advanced diagnostic imaging and technical therapeutic approaches for infrapopliteal occlusions, to a discussion of current standards and future directions. RECENT FINDINGS: Contemporary studies of infrapopliteal angioplasty show suboptimal short-term and 1-year clinical outcomes...
August 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28646041/concurrent-ox40-and-cd30-ligand-blockade-abrogates-the-cd4-driven-autoimmunity-associated-with-ctla4-and-pd1-blockade-while-preserving-excellent-anti-cd8-tumor-immunity
#3
Maher G Nawaf, Maria H Ulvmar, David R Withers, Fiona M McConnell, Fabrina M Gaspal, Gwilym J Webb, Nick D Jones, Hideo Yagita, James P Allison, Peter J L Lane
Although strategies that block FOXP3-dependent regulatory T cell function (CTLA4 blockade) and the inhibitory receptor PD1 have shown great promise in promoting antitumor immune responses in humans, their widespread implementation for cancer immunotherapy has been hampered by significant off-target autoimmune side effects that can be lethal. Our work has shown that absence of OX40 and CD30 costimulatory signals prevents CD4 T cell-driven autoimmunity in Foxp3-deficient mice, suggesting a novel way to block these side effects...
June 23, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28645531/new-protein-structures-provide-an-updated-understanding-of-phenylketonuria
#4
REVIEW
Eileen K Jaffe
Phenylketonuria (PKU) and less severe hyperphenylalaninemia (HPA) constitute the most common inborn error of amino acid metabolism, and is most often caused by defects in phenylalanine hydroxylase (PAH) function resulting in accumulation of Phe to neurotoxic levels. Despite the success of dietary intervention in preventing permanent neurological damage, individuals living with PKU clamor for additional non-dietary therapies. The bulk of disease-associated mutations are PAH missense variants, which occur throughout the entire 452 amino acid human PAH protein...
June 15, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28645314/neuromuscular-function-during-knee-extension-exercise-after-cold-water-immersion
#5
Hitoshi Wakabayashi, Titis Wijayanto, Yutaka Tochihara
BACKGROUND: Human adaptability to cold environment has been focused on in the physiological anthropology and related research area. Concerning the human acclimatization process in the natural climate, it is necessary to conduct a research assessing comprehensive effect of cold environment and physical activities in cold. This study investigated the effect of cold water immersion on the exercise performance and neuromuscular function during maximal and submaximal isometric knee extension...
June 23, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28644961/bisphenol-a-and-other-environmental-risk-factors-for-prostate-cancer-in-hong-kong
#6
Lap Ah Tse, Priscilla Ming Yi Lee, Wing Ming Ho, Augustine Tsan Lam, Man Kei Lee, Simon Siu Man Ng, Yonghua He, Ka-Sing Leung, Jennifer C Hartle, Howard Hu, Haidong Kan, Feng Wang, Chi Fai Ng
BACKGROUND: Environmental exposures are contributing factors to prostate cancer etiology, but these remain unclear. We aimed to document the associations between environmental risk factors and prostate cancer in Chinese, with special reference to bisphenol A (BPA). METHODS: We recruited 431 newly diagnosed prostate cancer cases and 402 age-matched controls from Prince of Wales Hospital in Hong Kong. We obtained each participant's clinical data and epidemiological information on chronic BPA exposure and other environmental risk factors (e...
June 20, 2017: Environment International
https://www.readbyqxmd.com/read/28644624/extensive-assessment-of-various-computational-methods-for-aspartate-s-pka-shift
#7
Zhaoxi Sun, Xiaohui Wang, Jianing Song
A series of computational methods for pKa shift prediction are extensively tested on a set of benchmark protein systems, aiming at identifying pitfalls and evaluating their performance on high variants. Including 19 ASP residues in 10 protein systems, the benchmark set consists of both residues with highly shifted pKa values as well as those varying little from the reference value, with an experimental RMS free energy differences of 2.49 kcal/mol with respect to blocked amino acid, namely the RMS pKa shift being 1...
June 23, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28644620/nanofibrous-smart-fabrics-from-twisted-yarns-of-electrospun-piezo-polymer
#8
Enlong Yang, Zhe Xu, Lucas Chur, Ali Behroozfar, Mahmoud Baniasadi, Salvador Moreno, Jiacheng Huang, Jules Gilligan, Majid Minary-Jolandan
Smart textiles are envisioned to make a paradigm shift in wearable technologies to directly impart functionality into the fibers rather than integrating sensors and electronics onto conformal substrates or skin in wearable devices. Among smart materials, piezoelectric fabrics have not been widely reported, yet. Piezoelectric smart fabrics can be used for mechanical energy harvesting, for thermal energy harvesting through the pyroelectric effect, for ferroelectric applications, as pressure and force sensors, for motion detection, and for ultrasonic sensing...
June 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28644487/-can-diabetes-be-treated-as-an-indirectly-work-related-disease
#9
Andrzej Marcinkiewicz, Anna Radomska, Wojciech Hanke, Jolanta Walusiak-Skorupa
In this article the authors attempted to analyze the arguments for considering diabetes as a work-related disease. An overview of literature has been done out of articles published in the years 1980-2016, with the use of combination of key words referring to employment, workplace, and diabetes. The PubMed database was the source of data. The authors indicate that the following arguments are in favor of diabetes being recognized as a work-related disease: diabetes is not an occupational disease, it is not directly related to the work environment or the way the work is performed, but there are observed adverse effects of occupational work-related nuisances, such as night shift work, long work hours, job strain or workplace standing time, which influence its development and course...
June 22, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28643445/a-novel-electrochemical-biosensor-with-dual-signal-outputs-toward-simultaneous-quantification-of-ph-and-o2-in-brain-upon-ischemia-and-in-tumor-during-cancer-therapy
#10
Li Liu, Fan Zhao, Wei Liu, Tong Zhu, Zh John Zhang, Chen Chen, Zhihui Dai, Huisheng Peng, Jun-Long Huang, Qin Hu, Wenbo Bu, Yang Tian
In this work, we develop a novel methodology for designing electrochemical biosensors with both current and potential signal outputs for simultaneous determination of two important species in the live systems. By designing a new molecule, Hemin-aminoferrocene (Hemin-Fc), we create a single electrochemical biosensor for simultaneous quantification of O2 and pH in brain upon ischemia and in tumor during cancer starvation therapy. The reduction peak current of Hemin group increases with rising concentrations of O2 from 1...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28642235/atomic-layered-au-clusters-on-%C3%AE-moc-as-catalysts-for-the-low-temperature-water-gas-shift-reaction
#11
Siyu Yao, Xiao Zhang, Wu Zhou, Rui Gao, Wenqian Xu, Yifan Ye, Lili Lin, Xiaodong Wen, Ping Liu, Bingbing Chen, Ethan Crumlin, Jinghua Guo, Zhijun Zuo, Weizhen Li, Jinglin Xie, Li Lu, Christopher J Kiely, Lin Gu, Chuan Shi, José A Rodriguez, Ding Ma
The water-gas shift (WGS) reaction (CO+H2O=H2+CO2) is an essential process for hydrogen generation and CO removal in various energy-related chemical operations. This equilibrium-limited reaction is favored at a low working temperature. Potential application in fuel cells also requires a WGS catalyst to be highly active, stable and energy-efficient and match the working temperature of on-site hydrogen generation and consumption units. We synthesized Au layered clusters on an α-MoC substrate to create an interfacial catalyst system for the ultra-low-temperature WGS reaction...
June 22, 2017: Science
https://www.readbyqxmd.com/read/28641935/fatty-acid-modified-gapmer-antisense-oligonucleotide-and-serum-albumin-constructs-for-pharmacokinetic-modulation
#12
Michael Lykke Hvam, Yunpeng Cai, Frederik Dagnæs-Hansen, Jesper Sejrup Nielsen, Jesper Wengel, Jørgen Kjems, Kenneth A Howard
Delivery technologies are required for realizing the clinical potential of molecular medicines. This work presents an alternative technology to preformulated delivery systems by harnessing the natural transport properties of serum albumin using endogenous binding of gapmer antisense oligonucleotides (ASOs)/albumin constructs. We show by an electrophoretic mobility assay that fatty acid-modified gapmer and human serum albumin (HSA) can self-assemble into constructs that offer favorable pharmacokinetics. The interaction was dependent on fatty acid type (either palmitic or myristic acid), number, and position within the gapmer ASO sequence, as well as phosphorothioate (PS) backbone modifications...
June 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28641436/doping-as-a-means-to-probe-the-potential-dependence-of-dopamine-adsorption-on-carbon-based-surfaces-a-first-principles-study
#13
Anja Aarva, Tomi Laurila, Miguel A Caro
In this work, we study the adsorption characteristics of dopamine (DA), ascorbic acid (AA), and dopaminequinone (DAox) on carbonaceous electrodes. Our goal is to obtain a better understanding of the adsorption behavior of these analytes in order to promote the development of new carbon-based electrode materials for sensitive and selective detection of dopamine in vivo. Here we employ density functional theory-based simulations to reach a level of detail that cannot be achieved experimentally. To get a broader understanding of carbonaceous surfaces with different morphological characteristics, we compare three materials: graphene, diamond, and amorphous carbon (a-C)...
June 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28641123/the-practice-environment-scale-of-the-nursing-work-index-an-updated-review-and-recommendations-for-use
#14
REVIEW
Pauline A Swiger, Patricia A Patrician, Rebecca S Susie Miltner, Dheeraj Raju, Sara Breckenridge-Sproat, Lori A Loan
OBJECTIVES: The Practice Environment Scale of the Nursing Work Index (PES-NWI) is an instrument, which measures the nursing practice environment - defined as factors that enhance or attenuate a nurse's ability to practice nursing skillfully and deliver high quality care. The purpose of this paper is to provide an updated review of the Practice Environment Scale of the Nursing Work Index's use to date and provide recommendations that may be helpful to nursing leaders and researchers who plan to use this instrument...
June 12, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28639370/b0-concomitant-field-compensation-for-mri-systems-employing-asymmetric-transverse-gradient-coils
#15
Paul T Weavers, Shengzhen Tao, Joshua D Trzasko, Louis M Frigo, Yunhong Shu, Matthew A Frick, Seung-Kyun Lee, Thomas K-F Foo, Matt A Bernstein
PURPOSE: Imaging gradients result in the generation of concomitant fields, or Maxwell fields, which are of increasing importance at higher gradient amplitudes. These time-varying fields cause additional phase accumulation, which must be compensated for to avoid image artifacts. In the case of gradient systems employing symmetric design, the concomitant fields are well described with second-order spatial variation. Gradient systems employing asymmetric design additionally generate concomitant fields with global (zeroth-order or B0 ) and linear (first-order) spatial dependence...
June 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28639331/top-down-integration-of-molybdenum-disulfide-transistors-with-wafer-scale-uniformity-and-layer-controllability
#16
Mao-Lin Shi, Lin Chen, Tian-Bao Zhang, Jing Xu, Hao Zhu, Qing-Qing Sun, David Wei Zhang
The lack of stable and efficient techniques to synthesize high-quality large-area thin films is one of the major bottlenecks for the real-world application of the 2D transition metal dichalcogenides. In this work, the growth of molybdenum disulfide (MoS2 ) on sapphire substrates by sulfurizing the MoO3 film deposited by atomic layer deposition (ALD) is reported. The advantages of the ALD method can be well inherited, and the synthesized MoS2 films exhibit excellent layer controllability, wafer-scale uniformity, and homogeneity...
June 22, 2017: Small
https://www.readbyqxmd.com/read/28639330/listening-for-commissioning-a-participatory-study-exploring-young-people-s-experiences-views-and-preferences-of-school-based-sexual-health-and-school-nursing
#17
Kay Aranda, Lester Coleman, N S Sherriff, Chris Cocking, Laetitia Zeeman, Liz Cunningham
AIMS AND OBJECTIVES: To explore the experiences, views and preferences of young people aged 11-19 years old regarding school-based sexual health and school nursing to inform commissioning for one local authority area in England during 2015. BACKGROUND: Promoting sexual health for young people remains a challenging, even controversial, but important public health issue. Concerns regarding accessibility, acceptability and efficacy in school-based sexual health and school nursing are evident in the literature...
June 21, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28638154/-assessment-of-predictive-dermal-exposure-to-chemicals-in-the-work-environment
#18
Agnieszka Jankowska, Sławomir Czerczak, Małgorzata Kupczewska-Dobecka
Assessment of dermal exposure to chemicals in the work environment is problematic, mainly as a result of the lack of measurement data on occupational exposure to chemicals. Due to common prevalence of occupational skin exposure and its health consequences it is necessary to look for efficient solutions allowing for reliable exposure assessment. The aim of the study is to present predictive models used to assess non-measured dermal exposure, as well as to acquaint Polish users with the principles of the selected model functioning...
June 14, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28638081/development-of-lysosome-mimicking-vesicles-to-study-the-effect-of-abnormal-accumulation-of-sphingosine-on-membrane-properties
#19
Ana C Carreira, Rodrigo F M de Almeida, Liana C Silva
Synthetic systems are widely used to unveil the molecular mechanisms of complex cellular events. Artificial membranes are key examples of models employed to address lipid-lipid and lipid-protein interactions. In this work, we developed a new synthetic system that more closely resembles the lysosome - the lysosome-mimicking vesicles (LMVs) - displaying stable acid-to-neutral pH gradient across the membrane. To evaluate the advantages of this synthetic system, we assessed the distinct effects of sphingosine (Sph) accumulation in membrane structure and biophysical properties of standard liposomes (no pH gradient) and in LMVs with lipid composition tuned to mimic physiological- or NPC1-like lysosomes...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28638065/colorimetric-detection-of-magnesium-ii-ions-using-tryptophan-functionalized-gold-nanoparticles
#20
Dae-Young Kim, Surendra Shinde, Gajanan Ghodake
The functional nanoparticles with specific molecular probe appear to be a promising approach for developing colorimetric nanosensor. In this work, we have synthesized tryptophan capped gold nanoparticles (AuNPs) and used to establish colorimetric detection of magnesium (Mg(2+)). The colorimetric response of the AuNPs toward Mg(2+) was noticed with naked eyes, and spectral changes were monitored by using UV-Vis spectrophotometer. The detection response was rapid (less than 1 min), with a detection limit (LOD) about 0...
June 21, 2017: Scientific Reports
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