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Aquaporin-4 antibodies

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https://www.readbyqxmd.com/read/29778487/clinical-characteristics-of-pediatric-optic-neuritis-with-myelin-oligodendrocyte-glycoprotein-seropositive-a-cohort-study
#1
Qian Chen, Guixian Zhao, Yongheng Huang, Zhenxin Li, Xinghuai Sun, Ping Lu, Yan San, Min Wang, Guohong Tian
BACKGROUND: The clinical characteristics of patients with pediatric optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibodies in Asia have not been reported. METHODS: Patients ≤18 years old with acute onset optic neuritis were enrolled. Serum myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies were detected and patients were followed-up for at least six months. The clinical features were evaluated among myelin oligodendrocyte glycoprotein-seropositive optic neuritis, aquaporin-4-seropositive optic neuritis, and double seronegative optic neuritis...
March 13, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29766684/neuromyelitis-optica-review-and-utility-of-testing-aquaporin-4-antibody-in-typical-optic-neuritis
#2
Meagan Seay, Janet C Rucker
Neuromyelitis optica (NMO) is an autoimmune, inflammatory demyelinating disorder often leading to severe vision impairment and disability. The discovery of a diagnostic biomarker, the aquaporin-4 antibody (AQP4-IgG), transformed the clinical diagnosis and treatment of NMO and broadened the spectrum of disease [NMO spectrum disorders (NMOSD)]. Though the antibody is highly sensitive and specific to NMOSD, routine testing in patients with typical optic neuritis is considered controversial. This article will provide a brief review of NMOSD and highlight the pros and cons of routine testing in typical optic neuritis...
May 16, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29755396/overlapping-autoimmune-syndromes-in-patients-with-glial-fibrillary-acidic-protein-antibodies
#3
Xinguang Yang, Huiming Xu, Meilin Ding, Qingmei Huang, Baikeng Chen, Huacai Yang, Tianni Liu, Youming Long, Cong Gao
Background: Glial fibrillary acidic protein (GFAP) astrocytopathy, an autoimmune central nervous system disorder with a specific GFAP-IgG, often coexists with other antibodies. Objective: The aim of this article was to study overlapping syndromes in autoimmune GFAP astrocytopathy. Methods: Antibody was detected by indirect immunofluorescence assay. Patient data were analyzed retrospectively. Results: Thirty patients with positive GFAP-IgG were included, of whom 10 were defined as overlapping syndrome...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29748202/mri-based-methods-for-spinal-cord-atrophy-evaluation-a-comparison-of-cervical-cord-cross-sectional-area-cervical-cord-volume-and-full-spinal-cord-volume-in-patients-with-aquaporin-4-antibody-seropositive-neuromyelitis-optica-spectrum-disorders
#4
C Chien, A U Brandt, F Schmidt, J Bellmann-Strobl, K Ruprecht, F Paul, M Scheel
BACKGROUND AND PURPOSE: Measures for spinal cord atrophy have become increasingly important as imaging biomarkers in the assessment of neuroinflammatory diseases, especially in neuromyelitis optica spectrum disorders. The most commonly used method, mean upper cervical cord area, is relatively easy to measure and can be performed on brain MRIs that capture cervical myelon. Measures of spinal cord volume (eg, cervical cord volume or total cord volume) require longer scanning and more complex analysis but are potentially better suited as spinal cord atrophy measures...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29724224/mog-encephalomyelitis-international-recommendations-on-diagnosis-and-antibody-testing
#5
REVIEW
S Jarius, F Paul, O Aktas, N Asgari, R C Dale, J de Seze, D Franciotta, K Fujihara, A Jacob, H J Kim, I Kleiter, T Kümpfel, M Levy, J Palace, K Ruprecht, A Saiz, C Trebst, B G Weinshenker, B Wildemann
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29722742/neuromyelitis-optica-and-herpes-simplex-virus-2-a-viral-trigger-for-aquaporin-4-autoimmunity
#6
I Vanessa Marin Collazo, Charles L Howe, Claudia F Lucchinetti, W Oliver Tobin
The clinical and radiographic spectrum of Neuromyelitis optica spectrum disorder has broadened following the description of the aquaporin-4 antibody. The initial triggering event and reason for disease quiescence between relapses is unclear. We present a case of myeloradiculitis associated with aquaporin-4 antibody and concomitant herpes simplex virus 2 infection.
May 2018: Neurologist
https://www.readbyqxmd.com/read/29721683/pediatric-neuromyelitis-optica-spectrum-disorders
#7
REVIEW
Grace Y Gombolay, Tanuja Chitnis
PURPOSE OF REVIEW: Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum disorders. The purpose of this review is to discuss the clinical features, along with management and treatment options, including potential future therapeutic options, in pediatric NMOSD...
May 2, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29710020/-a-15-year-old-girl-with-congenital-cytomegalovirus-infection-presenting-with-sensorineural-hearing-impairment-and-cerebral-while-matter-lesions-but-no-intellectual-disability
#8
Keiichi Nakagawa, Masato Kadoya, Hiroshi Matsumoto, Hiroyuki Moriuchi, Katsunori Ikewaki, Kenichi Kaida
A 15-year-old girl presented with non-progressive sensorineural hearing impairment in her right ear since her early childhood. She had normal intellectual development. When she was 15 years old, small deep white matter lesions around the lateral ventricles were incidentally detected in brain MRI studies through further investigation of auditory organs. Laboratory data including cerebrospinal fluid analysis and antibodies to aquaporin-4 or myelin-oligodendrocyte glycoprotein were normal. She was diagnosed as a congenital cytomegalovirus (CMV) infection based on the detection of CMV DNA from preserved umbilical cord tissue by real-time polymerase chain reaction...
April 28, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29695592/clinical-spectrum-and-prognostic-value-of-cns-mog-autoimmunity-in-adults-the-mogador-study
#9
Alvaro Cobo-Calvo, Anne Ruiz, Elisabeth Maillart, Bertrand Audoin, Helene Zephir, Bertrand Bourre, Jonathan Ciron, Nicolas Collongues, David Brassat, Francois Cotton, Caroline Papeix, Francoise Durand-Dubief, David Laplaud, Romain Deschamps, Mikaël Cohen, Damien Biotti, Xavier Ayrignac, Caroline Tilikete, Eric Thouvenot, Bruno Brochet, Cecile Dulau, Thibault Moreau, Ayman Tourbah, Pierre Lebranchu, Laure Michel, Christine Lebrun-Frenay, Alexis Montcuquet, Guillaume Mathey, Marc Debouverie, Jean Pelletier, Pierre Labauge, Nathalie Derache, Marc Coustans, Fabien Rollot, Jérôme De Seze, Sandra Vukusic, Romain Marignier
OBJECTIVE: To describe clinical and radiologic features associated with myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) in a large French nationwide adult cohort, to assess baseline prognostic features of MOG-Ab-associated diseases after a first acute demyelinating syndrome, and to evaluate the clinical value of MOG-Ab longitudinal analysis. METHODS: Clinical data were obtained from 197 MOG-Ab-positive patients ≥18 years of age. Complete imaging data were available in 108, and 54 serum samples were eligible for longitudinal evaluation...
April 25, 2018: Neurology
https://www.readbyqxmd.com/read/29685427/neuromyelitis-optica-spectrum-disorders-features-of-aquaporin-4-myelin-oligodendrocyte-glycoprotein-and-double-seronegative-mediated-subtypes
#10
REVIEW
C Alves Do Rego, N Collongues
The new diagnostic classification of neuromyelitis optica spectrum disorder (NMOSD) in 2015 highlights the central role of biomarkers, such as antibodies against aquaporin-4 (AQP4-Ab), in diagnosis. Also, in approximately 20-25% of patients without AQP4-Ab (NMOSDAQP4- ) the presence of an antibody directed against myelin oligodendrocyte glycoprotein (MOG) characterizes a specific population of NMOSD patients (NMOSDMOG+ ), according to their demographic and clinical data and prognoses. While double-seronegative cases (NMOSDNEG ) have not been fully described, they may correspond to the very first patients with opticospinal demyelination reported by Devic and Gault in 1894...
April 20, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29676196/contiguous-and-symmetrical-disease-expansion-and-massive-necrosis-of-the-cerebral-white-matter-in-a-patient-with-neuromyelitis-optica
#11
Chiho Ishida, Tokuhei Ikeda, Kiyonobu Komai, Kazuya Takahashi, Moeko Noguchi-Shinohara, Masahito Yamada
The present report discusses the case of a woman with neuromyelitis optica (NMO) who exhibited bilateral optic neuritis, longitudinally extensive myelitis, serum anti-aquaporin-4 antibodies, and a unique pattern of white matter involvement. The disease duration was 26 years, and the patient died at the age of 65 years. Sequential magnetic resonance images obtained during the last 6 years of life revealed leukoencephalopathy-like lesions extending symmetrically and contiguously from the periventricular regions, which had begun to transform into multiple cavities with semi-annular partitions...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29675599/immunoadsorption-plasmapheresis-treatment-for-the-recurrent-exacerbation-of-neuromyelitis-optica-spectrum-disorder-with-a-fluctuating-anti-aquaporin-4-antibody-level
#12
Hiroaki Nishimura, Hideki Enokida, Taiji Sakamoto, Toshiyuki Takahashi, Hiroshi Hayami, Masayuki Nakagawa
The pathogenesis in the exacerbation of neuromyelitis optica spectrum disorder (NMOSD) involves mainly the serum anti-aquaporin-4 (AQP4) immunoglobulin G antibody (anti-AQP4 antibody). If high-dose corticosteroid treatment is not achieved during remission, rescue plasmapheresis is recommended. However, there are few reports on the therapeutic efficacy of repetitive immunoadsorption plasmapheresis (IAPP) for the recurrent exacerbation of NMOSD with a fluctuating anti-AQP4 antibody level. A 36-year-old man presented with a reduction of visual acuity (VA) on the right eye (OD) to 20/250...
April 19, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29670575/mog-igg-associated-optic-neuritis-encephalitis-and-myelitis-lessons-learned-from-neuromyelitis-optica-spectrum-disorder
#13
REVIEW
Giordani Rodrigues Dos Passos, Luana Michelli Oliveira, Bruna Klein da Costa, Samira Luisa Apostolos-Pereira, Dagoberto Callegaro, Kazuo Fujihara, Douglas Kazutoshi Sato
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29665816/selective-localization-of-igg-from-cerebrospinal-fluid-to-brain-parenchyma
#14
Marlene Thorsen Mørch, Sofie Forsberg Sørensen, Reza Khorooshi, Nasrin Asgari, Trevor Owens
BACKGROUND: Encounter of autoantibodies with specific antigens can lead to hypersensitivity reactions and pathology. In multiple sclerosis and neuromyelitis optica spectrum disease (NMOSD), immunoglobulin-G (IgG) deposition has been observed in pathological lesions in the central nervous system. The paradigmatic autoantibodies in NMOSD are specific for the water channel aquaporin-4, localized to astrocytic end-feet at the blood-brain barrier and ependymal cells at the cerebrospinal fluid-brain barrier...
April 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29655487/frequency-of-aquaporin-4-immunoglobulin-g-in-longitudinally-extensive-transverse-myelitis-with-antiphospholipid-antibodies
#15
Hilda Guerra, Sean J Pittock, Kevin G Moder, James P Fryer, Avi Gadoth, Eoin P Flanagan
Antiphospholipid (aPL) antibodies have historically been postulated to cause a poorly understood inflammatory myelitis. Neuromyelitis optica spectrum disorder (NMOSD) causes an inflammatory longitudinally extensive transverse myelitis (LETM). In 2004, aquaporin-4 immunoglobulin G (AQP4-IgG) was first reported as a highly specific (>99%) serum diagnostic biomarker of NMOSD, distinguishing it from other disorders (eg, multiple sclerosis). We sought to assess the frequency of AQP4-IgG (and thus NMOSD diagnosis) in LETM with aPL antibodies...
April 11, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29623106/defining-distinct-features-of-anti-mog-antibody-associated-central-nervous-system-demyelination
#16
REVIEW
Martin S Weber, Tobias Derfuss, Imke Metz, Wolfgang Brück
Extensive research over the last decades basically failed to identify a common cause of noninfectious inflammatory central nervous system (CNS) demyelinating disease. To a great extent, this may reflect that the group of inflammatory CNS demyelinating disorders likely contains multiple pathogenetically distinct disease entities. Indeed, the greatest success so far in deciphering the pathogenesis of a CNS demyelinating disorder resulted from the discovery of anti-aquaporin (AQP)-4 antibodies (ab), which allowed progressive delineation of neuromyelitis optica (NMO), formerly considered a variant of the most common CNS demyelinating disorder, multiple sclerosis (MS), as a distinct disease...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29606515/plasma-exchange-for-neuromyelitis-optica-spectrum-disorders-in-chinese-patients-and-factors-predictive-of-short-term-outcome
#17
Yujuan Jiao, Lei Cui, Weihe Zhang, Yeqiong Zhang, Wei Wang, Linwei Zhang, Wenxiong Tang, Jinsong Jiao
PURPOSE: The purposes of this article were to evaluate the short-term outcome of plasma exchange (PLEX) for neuromyelitis optica spectrum disorders (NMOSDs) in Chinese patients and to identify the factors predictive of a favorable response to therapy. METHODS: We retrospectively analyzed data from 29 Chinese patients with NMOSD. All patients received 2 to 7 sessions of PLEX every other day. Expanded Disability Status Scale (EDSS) scores were estimated at baseline, at relapse, and before and at follow-up after PLEX...
March 29, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29573397/myelin-oligodendrocyte-glycoprotein-and-aquaporin-4-antibodies-in-children-with-acquired-demyelinating-syndromes
#18
Kevin Rostásy
No abstract text is available yet for this article.
March 24, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29571849/oligoclonal-bands-and-periventricular-lesions-in-multiple-sclerosis-will-not-increase-blood-brain-barrier-permeability
#19
Tetsuya Akaishi, Toshiyuki Takahashi, Ichiro Nakashima
OBJECTIVE: To elucidate the etiology and clinical significance of periventricular lesions (PVLs) and oligoclonal bands (OB) in multiple sclerosis (MS). METHODS: We enrolled a total of 97 MS patients (67 OB-positive and 30 OB-negative) who were negative both for anti-aquaporin-4 (AQP4) autoantibody and anti-myelin oligodendrocyte glycoprotein (MOG) antibody. In these patients, comprehensive data including clinical, laboratory, and MRI were collected to investigate the significance of OB and PVLs...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29544193/autoimmune-and-immunogenetic-profile-of-patients-with-optic-neuritis-in-a-population-based-cohort
#20
K Soelberg, A C Nilsson, C Nielsen, S Jarius, M Reindl, B Wildemann, S T Lillevang, N Asgari
BACKGROUND: Optic neuritis (ON) is an inflammatory optic neuropathy, where the genetic and autoimmune dependency remains poorly characterized. OBJECTIVE: To investigate autoimmune and immunogenetic aspects of ON. METHOD: In a prospective population-based cohort 51 patients with ON were included. At follow up 20 patients had progressed to multiple sclerosis (MS-ON). All patients were screened for neuronal and systemic autoantibodies. HLA genotypes and allele and genotype frequencies of the PTPN22 C1858T and the PD-1...
April 2018: Multiple Sclerosis and related Disorders
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