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https://www.readbyqxmd.com/read/28730087/frequency-of-diabetic-retinopathy-and-associated-risk-factors-in-khartoum-sudan-population-based-study
#1
Einas S Elwali, Ahmed O Almobarak, Mona A Hassan, Amir A Mahmooud, Heitham Awadalla, Mohamed H Ahmed
AIM: To assess the frequency and associated risk factors of diabetic retinopathy among Sudanese individuals with diabetes attending Makka Eye complex in Khartoum, Sudan. METHODS: The cross sectional hospital based study recruited 316 individuals with diabetes from Makkah Eye Complex Retina Clinic. Standard questionnaire was used to collect demographic data, medical history and life style characteristics. Blood samples were taken to measure HbA1c and lipid profile...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28728182/endophthalmitis-and-concurrent-or-delayed-onset-rhegmatogenous-retinal-detachment-managed-with-pars-plana-vitrectomy-intravitreal-antibiotics-and-silicone-oil
#2
Vivek Pravin Dave, Avinash Pathengay, Nidhi Relhan, Pranjali Sharma, Subhadra Jalali, Rajeev Reddy Pappuru, Mudit Tyagi, Raja Narayanan, Jay Chhablani, Taraprasad Das, Harry W Flynn
BACKGROUND AND OBJECTIVE: The current study describes the treatment outcomes in patients with endophthalmitis and concurrent or delayed-onset retinal detachment managed with pars plana vitrectomy, intravitreal antibiotics, and silicone oil. PATIENTS AND METHODS: In this noncomparative, retrospective case series, the medical records of patients diagnosed with endophthalmitis and retinal detachment from January 1991 through December 2014 at a tertiary eye care center in South India were reviewed...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28712537/efficacy-and-safety-of-voretigene-neparvovec-aav2-hrpe65v2-in-patients-with-rpe65-mediated-inherited-retinal-dystrophy-a-randomised-controlled-open-label-phase-3-trial
#3
Stephen Russell, Jean Bennett, Jennifer A Wellman, Daniel C Chung, Zi-Fan Yu, Amy Tillman, Janet Wittes, Julie Pappas, Okan Elci, Sarah McCague, Dominique Cross, Kathleen A Marshall, Jean Walshire, Taylor L Kehoe, Hannah Reichert, Maria Davis, Leslie Raffini, Lindsey A George, F Parker Hudson, Laura Dingfield, Xiaosong Zhu, Julia A Haller, Elliott H Sohn, Vinit B Mahajan, Wanda Pfeifer, Michelle Weckmann, Chris Johnson, Dina Gewaily, Arlene Drack, Edwin Stone, Katie Wachtel, Francesca Simonelli, Bart P Leroy, J Fraser Wright, Katherine A High, Albert M Maguire
BACKGROUND: Phase 1 studies have shown potential benefit of gene replacement in RPE65-mediated inherited retinal dystrophy. This phase 3 study assessed the efficacy and safety of voretigene neparvovec in participants whose inherited retinal dystrophy would otherwise progress to complete blindness. METHODS: In this open-label, randomised, controlled phase 3 trial done at two sites in the USA, individuals aged 3 years or older with, in each eye, best corrected visual acuity of 20/60 or worse, or visual field less than 20 degrees in any meridian, or both, with confirmed genetic diagnosis of biallelic RPE65 mutations, sufficient viable retina, and ability to perform standardised multi-luminance mobility testing (MLMT) within the luminance range evaluated, were eligible...
July 13, 2017: Lancet
https://www.readbyqxmd.com/read/28676565/an-interview-with-bill-harris
#4
Aidan Maartens
William 'Bill' Harris is Head of the Department of Physiology, Development and Neuroscience at the University of Cambridge, UK, and a Fellow of both the Royal Society and Academy of Medical Sciences. His lab works on the development of the vertebrate nervous system, with a particular focus on cell lineage in the retina. In 2017 he was awarded the British Society for Developmental Biology's Waddington Medal for outstanding research performance and services to the community. We met Bill in his Cambridge lab to talk science, art and ice hockey...
July 1, 2017: Development
https://www.readbyqxmd.com/read/28673747/philadelphia-telemedicine-glaucoma-detection-and-follow-up-study-methods-and-screening-results
#5
Lisa A Hark, L Jay Katz, Jonathan S Myers, Michael Waisbourd, Deiana Johnson, Laura T Pizzi, Benjamin E Leiby, Scott J Fudemberg, Anand V Mantravadi, Jeffrey D Henderer, Tingting Zhan, Jeanne Molineaux, Vance Doyle, Meskerem Divers, Christine Burns, Ann P Murchison, Shae Reber, Arthur Resende, Thien Dan V Bui, Jane Lee, John E Crews, Jinan B Saaddine, Paul P Lee, Louis R Pasquale, Julia A Haller
PURPOSE: To describe methodology and screening results from the Philadelphia Telemedicine Glaucoma Detection and Follow-up Study. DESIGN: Screening program results for a prospective, randomized clinical trial. MATERIALS AND METHODS: Individuals were recruited who were African-American, Hispanic/Latino, or Asian over age 40 years; Caucasian individuals over age 65 years; any ethnicity over age 40 years with a family history of glaucoma or diabetes...
June 30, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28672976/suncon-medical-adhesive-is-a-suitable-alternative-to-fibrin-glue-in-the-23g-minimally-invasive-vitrectomy
#6
Sha Liu, Suyan Li, Zhengpei Zhang, Sujuan Ji, Haiyang Liu
Fibrin glue is frequently used to close the incision of the sclera and conjunctiva. However, its use is limited due to its blood-borne origins. The study evaluated the suitability of Suncon medical adhesive as a replacement for fibrin glue in 23G minimally invasive vitrectomy as an animal study. One eye of Japanese white rabbits (total, 18 rabbits) received an intravitreal injection of 0.05 ml of Suncon medical adhesive, while the other eye was injected with 0.05 ml of saline and served as the control eye. Slit lamp, indirect ophthalmoscope and electroretinogram (ERG) examinations were carried out before and 28 days after the interventions...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28657533/-the-ametrop%C3%A3-as-updated-review-for-non-ophthalmologists-physicians
#7
REVIEW
Virgilio Galvis, Alejandro Tello, Oscar Blanco, Andrea N Laiton, Marion R Dueñas, Priscila Alejandra Hidalgo
Refractive errors are caused by a decoupling of the power of convergence of the eye lens, the cornea and lens, which make the rays reaching the eye to focus and generate an image, and the retina, which is the biological photosensitive screen where the image will be transformed into a nerve impulse. These defects include myopia, hyperopia and astigmatism. Presbyopia can also be considered a refractive defect, but of special features, since only affects near vision in patients older than 40 years. By altering the quality of the focused image on the most sensitive area of the retina (the macula), they decrease visual acuity...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28639324/a-retina-like-dual-band-organic-photosensor-array-for-filter-free-near-infrared-to-memory-operations
#8
Hanlin Wang, Hongtao Liu, Qiang Zhao, Zhenjie Ni, Ye Zou, Jie Yang, Lifeng Wang, Yanqiu Sun, Yunlong Guo, Wenping Hu, Yunqi Liu
Human eyes use retina photoreceptor cells to absorb and distinguish photons from different wavelengths to construct an image. Mimicry of such a process and extension of its spectral response into the near-infrared (NIR) is indispensable for night surveillance, retinal prosthetics, and medical imaging applications. Currently, NIR organic photosensors demand optical filters to reduce visible interference, thus making filter-free and anti-visible NIR imaging a challenging task. To solve this limitation, a filter-free and conformal, retina-inspired NIR organic photosensor is presented...
June 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28616257/book-review-spectral-domain-optical-coherence-tomography-in-macular-diseases
#9
Müller Gonçalves Urias, Eduardo Büchele Rodrigues
This is a review of the book Spectral Domain Optical Coherence Tomography in Macular Diseases edited by Meyer et al. (Spectral domain optical coherence tomography in macular diseases. Springer, New York, [2017]). The book provides clinicians both basic and advanced understanding of OCT applications in the field of medical retina.
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28613356/outpatient-wide-field-digital-imaging-of-infants-with-retinopathy-of-prematurity
#10
Robert W Arnold, Robin L Grendahl, R Kevin Winkle, Jack Jacob
Eight infants were closely monitored for retinopathy of prematurity (ROP) while in the neonatal intensive care unit (NICU); two required laser therapy. After discharge from the NICU, they had outpatient examination with dilated, scleral depressed ROP staging, and each had digital widefield retinal imaging (Optos, Dunfermline, United Kingdom) without lid speculum, or with lid speculum if not cooperative. Images were shared remotely using ROP-Check software (Glacier Medical Software, Anchorage, AK), from which ophthalmologists made clinical impressions...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28611650/anterior-360%C3%A2-synechiolysis-in-a-case-of-late-iridocorneal-adhesions-after-25-g-vitrectomy-surgical-and-physiopathogenetic-aspects
#11
Raffaele Nuzzi, Francesca Monteu
We describe the case of an 86-year-old patient, pseudophakic in both eyes and with high myopia, who had previously had a 25-G vitrectomy with 20% C3F8 used as a tamponade due to a total retinal detachment with choroidal hemorrhages and macular hole. At the postoperative 4-month follow-up, we found 360° iridocorneal synechiae with elevated intraocular pressure due to angle closure in all sectors, with an adherent retina and in the absence of choroidal hemorrhage/detachment and of corneal edema or endothelial damage...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28609333/feasibility-of-the-digital-retinography-system-camera-in-the-pediatric-emergency-department
#12
Yaron Ivan, Sriram Ramgopal, Margarita Cardenas-Villa, Daniel G Winger, Li Wang, Melissa A Vitale, Richard A Saladino
PURPOSE: Direct ophthalmoscopy may be difficult without pupillary dilation and patient cooperation. Nonmydriatic ocular fundus photography (NMOFP) has been shown to be easily and efficiently accomplished by medical providers and improve the detection of abnormalities in adult emergency department (ED) patients. Nonmydriatic ocular fundus photography for pediatric ED patients has not been studied. The purpose of this study was to assess the ease of use of the Digital Retinography System (DRS) camera for NMOFP in ED patients aged 5 to 12 years and the quality of retinal images obtained with the DRS...
June 12, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28599600/transcriptional-changes-in-the-mouse-retina-following-ocular-blast-injury-a-role-for-the-immune-system
#13
Felix L Struebing, Rebecca King, Ying Li, Micah A Chrenek, Polina N Lyuboslavsky, Curran S Sidhu, P Michael Iuvone, Eldon E Geisert
Ocular blast injury is a major medical concern for soldiers and explosion victims due to poor visual outcomes. To define the changes in gene expression following a blast injury to the eye, we examined retinal RNA expression in 54 mouse strains five days after a single 50psi overpressure air wave blast injury. We observe that almost 40% of genes are differentially expressed with a false discovery rate of <0.001, even though the nominal changes in RNA expression are rather small. Moreover, we find through machine learning approaches that genetic networks related to the innate and acquired immune system are activated...
June 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28598043/clinical-profile-of-hypertensive-emergencies-in-an-intensive-care-unit
#14
Shubhangi V Dhadke, Vithal N Dhadke, Dhruv S Batra
AIMS AND OBJECTIVE: To study the prevalence of hypertensive emergencies in an ICU set up and to study the clinical presentation of hypertensive emergencies related to cardiovascular, neurological and renovascular system. METHODS: Type of Study: Cross-sectional, descriptive study. DURATION OF STUDY: Two years from 1st December 2011 till 30th November 2013. SAMPLE SIZE: 50 patients of hypertensive emergencies admitted to the intensive care unit of Dr...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28588773/target-volume-dose-and-clinical-outcome-in-radiotherapy-for-primary-marginal-zone-lymphoma-of-the-ocular-adnexa
#15
Natuhiko Shirota, Hidetsugu Nakayama, Sachica Shiraishi, Yoshihiko Usui, Keisuke Kimura, Tomohide Sanada, Norifumi Kennoki, Mitsuru Okubo, Hiroshi Goto, Koichi Tokuuye
The aim of the present study was to determine the optimal dose and optimal target volume for marginal zone lymphoma of the ocular adnexa. Between January, 2008 and December, 2013, 40 patients with histologically proven primary marginal zone lymphoma of the ocular adnexa who underwent radiotherapy at the Tokyo Medical University were evaluated. The prescribed dose was 30 Gy in 15 fractions to the iso-center. Doses to the gross tumor volume (GTV), conjunctiva, bulbus oculi, retina and retrobulbar space were investigated, and the association between dose-volume factors and clinical outcome was analyzed...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28586073/effects-of-the-tangningtongluo-formula-as-an-alternative-strategy-for-diabetics-via-upregulation-of-insulin-receptor-substrate-1
#16
Long Cheng, Junmei Song, Geng Li, Yue Liu, Yuming Wang, Xiangbao Meng, Guibo Sun, Xiaobo Sun
Tangningtongluo (TNTL), a traditional Chinese medicine, has been widely used in clinics for decades in southwest China. Its pharmacological properties and underlying molecular mechanisms remain unclear. The main goal of ethnopharmacology is to identify novel bioactive compounds derived from plants for use in indigenous medical practice. This knowledge can be used to develop novel pharmaceuticals. In the present study, hyperglycemic C57BL/KsJ‑db/db (db/db) mice were used to test the effect of TNTL on microvasculature of the retina and hypoglycemia...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28579549/the-use-of-microperimetry-in-assessing-visual-function-in-age-related-macular-degeneration
#17
REVIEW
Nicola K Cassels, John M Wild, Tom H Margrain, Victor Chong, Jennifer H Acton
Microperimetry is a novel technique for assessing visual function and appears particularly suitable for age-related macular degeneration (AMD). Compared to standard automated perimetry (SAP), microperimetry offers several unique features. It simultaneously images the fundus, incorporates an eye tracking system to correct the stimulus location for fixation loss, and identifies any preferred retinal loci. A systematic review of microperimetry in the assessment of visual function in AMD identified 680 articles...
June 1, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28570723/oral-tyrosine-kinase-inhibitor-for-neovascular-age-related-macular-degeneration-a-phase-1-dose-escalation-study
#18
Timothy L Jackson, David Boyer, David M Brown, Nauman Chaudhry, Michael Elman, Chris Liang, Denis O'Shaughnessy, Edward C Parsons, Sunil Patel, Jason S Slakter, Philip J Rosenfeld
Importance: An oral treatment for neovascular age-related macular degeneration would be less burdensome than repeated intravitreous injections. X-82 is an oral tyrosine kinase inhibitor active against vascular endothelial growth factor (VEGF) and platelet-derived growth factor. Objective: To undertake safety testing of oral X-82 administered for the treatment of neovascular AMD. Design, Setting, and Participants: Phase 1, open-label, uncontrolled, dose-escalation study at 5 US retinal clinics between November 2012 and March 2015 (Retina-Vitreous Associates Medical Group, Beverly Hills, California; Blanton Eye Institute, Houston Methodist Hospital, Retina Consultants of Houston, Houston, Texas; New England Retina Associates, Guilford, Connecticut; Elman Retina Group, Baltimore, Maryland; and Retina Research Institute of Texas, Abilene)...
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28553068/comparison-of-retina-specialist-preferences-regarding-spectral-domain-and-swept-source-optical-coherence-tomography-angiography
#19
Grace L Su, Douglas M Baughman, Qinqin Zhang, Kasra Rezaei, Aaron Y Lee, Cecilia S Lee
PURPOSE: The aim of this study was to compare physician preferences regarding the commercially available spectral-domain (SD) optical coherence tomography angiography (OCTA) and swept-source (SS) OCTA prototype device. DESIGN: Comparative analysis of diagnostic instruments was performed. PATIENTS AND METHODS: Subjects at the University of Washington Eye Institute and Harborview Medical Center were prospectively recruited and imaged with the Zeiss SD OCTA (HD-5000, Angioplex) and Zeiss SS OCTA (Plex Elite, Everest) devices on the same day...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28550590/exome-sequencing-identifies-candidate-genetic-modifiers-of-syndromic-and-familial-thoracic-aortic-aneurysm-severity
#20
Benjamin J Landis, Jeffrey A Schubert, Dongbing Lai, Anil G Jegga, Amy R Shikany, Tatiana Foroud, Stephanie M Ware, Robert B Hinton
Thoracic aortic aneurysm (TAA) is a genetic disease predisposing to aortic dissection. It is important to identify the genetic modifiers controlling penetrance and expressivity to improve clinical prognostication. Exome sequencing was performed in 27 subjects with syndromic or familial TAA presenting with extreme phenotypes (15 with severe TAA; 12 with mild or absent TAA). Family-based analysis of a subset of the cohort identified variants, genes, and pathways segregating with TAA severity among three families...
May 26, 2017: Journal of Cardiovascular Translational Research
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