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Medical retina

Takehiro Matsumura, Yoshihiro Takamura, Takeshi Tomomatsu, Shogo Arimura, Makoto Gozawa, Akira Kobori, Masaru Inatani
PURPOSE: To evaluate the efficacy of the inverted internal limiting membrane (ILM) flap technique in vitrectomy for macular hole (MH) with retinal detachment (RD) compared with vitrectomy using ILM peeling. METHODS: A retrospective case series study was performed. Twenty-two eyes of 22 patients who underwent vitrectomy for MH with RD and followed-up more than 12 months after the surgery were included in this study. We retrospectively reviewed the medical records of patients who underwent vitrectomy with inverted ILM flap technique or vitrectomy with ILM peeling...
2016: PloS One
Dierck Hillmann, Hendrik Spahr, Carola Hain, Helge Sudkamp, Gesa Franke, Clara Pfäffle, Christian Winter, Gereon Hüttmann
Certain topics in research and advancements in medical diagnostics may benefit from improved temporal and spatial resolution during non-invasive optical imaging of living tissue. However, so far no imaging technique can generate entirely diffraction-limited tomographic volumes with a single data acquisition, if the target moves or changes rapidly, such as the human retina. Additionally, the presence of aberrations may represent further difficulties. We show that a simple interferometric setup-based on parallelized optical coherence tomography-acquires volumetric data with 10 billion voxels per second, exceeding previous imaging speeds by an order of magnitude...
October 20, 2016: Scientific Reports
Elizabeth A Atchison, Ahmed F Omar, Raymond Iezzi, Andrew J Barkmeier, Sophie J Bakri
PURPOSE: To examine the safety outcomes of an intravitreal injection-only clinic where patients needing long-term anti-vascular endothelial growth factor therapy are treated with injections at a predetermined interval for a set number of injections without an accompanying clinic visit. METHODS: This is a retrospective chart review of all patients with exudative macular degeneration treated in an intravitreal injection clinic over a 4-year period. Data on the outcome measures of interest were gathered from electronic medical records...
October 18, 2016: Retina
Yue Xu, Boyu Yang, Yaguang Hu, Lin Lu, Xi Lu, Jiawei Wang, Fan Xu, Shanshan Yu, Jingjing Huang, Xiaoling Liang
Chronic neuro-inflammation is involved in the death of retinal ganglion cells (RGCs) in glaucoma. The aim of this study is to determine whether wogonin can suppress inflammatory responses and rescue RGCs death after optic nerve crush (ONC), an ideal animal model of glaucoma. Wogonin was administered intraperitoneally 10 min after establishment of ONC model. In this study, wogonin treatment reduced RGCs loss and inhibited RGCs apoptosis demonstrated by the increased Brn3a labeling RGCs at day 14 and the decreased cleaved caspase-3 expression at day 7 after ONC, respectively...
October 16, 2016: Oncotarget
Lydia Marahrens, Focke Ziemssen, Andreas Fritsche, Tjalf Ziemssen, Raimar Kern, Peter Martus, Daniel Roeck
PURPOSE: Facing the lack of time, busy retina consultants should be aware of how the patients would prefer that time is spent and whether they wish the specialist to talk more at the expense of other medical activities. METHODS: 810 persons with diabetes were asked to divide the time of 10 min between examination, consultation and treatment when envisioning a real-life scenario of diabetic retinopathy (NCT02311504). RESULTS: With the increasing duration of diabetes, patients wanted significantly more time for diagnostics (p = 0...
October 5, 2016: Ophthalmologica. Journal International D'ophtalmologie
Daniel Ontaneda, Robert J Fox
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Magnetic resonance imaging (MRI) is sensitive to lesion formation both in the brain and spinal cord. Imaging plays a prominent role in the diagnosis and monitoring of MS. Over a dozen anti-inflammatory therapies are approved for MS and the development of many of these medications was made possible through the use of contrast-enhancing lesions on MRI as a phase II outcome. A similar phase II outcome method for the neurodegeneration that underlies progressive courses of the disease is still unavailable...
October 3, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
Ama Sadaka, Robert A Sisk, James M Osher, Okan Toygar, Melinda K Duncan, Christopher D Riemann
PURPOSE: The purpose of this study was to evaluate intravitreal methotrexate infusion (IMI) during pars plana vitrectomy (PPV) for retinal detachment in patients with high risk for the development of proliferative vitreoretinopathy (PVR). METHODS: Patients presenting with severe recurrent PVR with tractional retinal detachment and/or a history of severe ocular inflammation were treated with IMI. Clinical outcomes were determined from a retrospective medical chart review...
2016: Clinical Ophthalmology
Pietro Emanuele Napoli, Alberto Cuccu, Roberta Farci, Maurizio Fossarello
BACKGROUND: Cilioretinal artery (CRA) occlusions are rare in young patients. In these cases, the most commonly associated causes are considered to be the same as those implicated in central retina artery occlusions, such as vasculitic processes, migraine, cardiac disorder, and coagulation abnormality. The aim of this article was to report for the first time the medical records and investigational results of an unusual case of simultaneous occlusion of three CRAs after scleral buckling surgery under local anesthesia...
2016: International Medical Case Reports Journal
Ben M Sörensen, Alfons J H M Houben, Tos T J M Berendschot, Jan S A G Schouten, Abraham A Kroon, Carla J H van der Kallen, Ronald M A Henry, Annemarie Koster, Simone J S Sep, Pieter C Dagnelie, Nicolaas C Schaper, Miranda T Schram, Coen D A Stehouwer
BACKGROUND: -Type 2 diabetes (T2DM) is associated with an increased risk of cardiovascular disease (CVD). This can be partly explained by large artery dysfunction, which already occurs in prediabetes ('ticking clock hypothesis'). Whether a similar phenomenon also applies to microvascular dysfunction is not known. We therefore tested the hypothesis that microvascular dysfunction is already present in prediabetes and is more severe in T2DM. To do so, we investigated the associations of prediabetes, T2DM, and measures of hyperglycemia with microvascular function measured as flicker light-induced retinal arteriolar dilation and heat-induced skin hyperemia...
September 27, 2016: Circulation
Donají Chi-Castañeda, Arturo Ortega
Circadian rhythms are periodic patterns in biological processes that allow the organisms to anticipate changes in the environment. These rhythms are driven by the suprachiasmatic nucleus (SCN), the master circadian clock in vertebrates. At a molecular level, circadian rhythms are regulated by the so-called clock genes, which oscillate in a periodic manner. The protein products of clock genes are transcription factors that control their own and other genes' transcription, collectively known as "clock-controlled genes...
October 2016: ASN Neuro
N Heim, A Faron, J Fuchs, M Martini, R H Reich, K Löffler
BACKGROUND: Investigations have shown that the internet as a source of information in medical issues is increasing in importance. For most patients information delivered or supported by hospitals and universities is considered to be the most reliable, however, the comprehensibility of available information is often considered to be wanting. Comprehensibility scores are formulae allowing a quantitative value for the readability of a document to be calculated. OBJECTIVE: The purpose of this study was to assess data by analyzing the comprehensibility of medical information published on the websites of departments for ophthalmology of German university hospitals...
September 9, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
M Becatti, R Marcucci, A M Gori, L Mannini, E Grifoni, A Alessandrello Liotta, A Sodi, R Tartaro, N Taddei, S Rizzo, D Prisco, R Abbate, C Fiorillo
: Essentials Retinal vein occlusion (RVO), characterized by blood hyperviscosity, has an unclear pathogenesis. We aimed to find out if hemorheological profile is altered by oxidative stress in RVO patients. Red blood cell (RBC) oxidative stress is associated to whole blood viscosity and RBC deformability. Reactive oxygen species alter RBC membrane rigidity, playing a key role in RVO pathogenesis. SUMMARY: Background Retinal vein occlusion (RVO) is characterized by vision loss resulting from hypoperfusion and hypoxia of the retina...
August 25, 2016: Journal of Thrombosis and Haemostasis: JTH
Franziska Ullrich, Stephan Michels, Daniel Lehmann, Roel S Pieters, Matthias Becker, Bradley J Nelson
Intravitreal therapy is the most common treatment for many chronic ophthalmic diseases, such as age-related macular degeneration. Due to the increasing worldwide demand for intravitreal injections, there exists a need to render this medical procedure more time- and cost-efficient while increasing patient safety. The authors propose a medical assistive device that injects medication intravitreally. Compared to the manual intravitreal injection procedure, an automated device has the potential to increase safety for patients, decrease procedure times, allow for integrated data storage and documentation, and reduce costs for medical staff and expensive operating rooms...
August 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Hyung Il Kim, Sun-Sook Paik, Gyu Hyun Kim, Muyan Kim, Soon Ha Kim, In-Beom Kim
NecroX-5 is a derivative of cyclopentylamino carboxymethylthiazolylindole (NecroX), an inhibitor of necrosis/necroptosis. NecroX-5 has been shown to scavenge mitochondrial reactive oxygen and nitrogen species, and thus preventing necrotic cell death against various kinds of oxidative stress in several tissues, including the brain. To examine the effect of NecroX-5 on retinal degeneration (RD), RD was induced in Sprague-Dawley rats by an intraperitoneal injection of N-methyl-N-nitrosourea and in BALB/c mice by blue light-emitting diode exposure...
October 19, 2016: Neuroreport
Yutao Liu, Jessica Cooke Bailey, Inas Helwa, W Michael Dismuke, Jingwen Cai, Michelle Drewry, Murray H Brilliant, Donald L Budenz, William G Christen, Daniel I Chasman, John H Fingert, Douglas Gaasterland, Terry Gaasterland, Mae O Gordon, Robert P Igo, Jae H Kang, Michael A Kass, Peter Kraft, Richard K Lee, Paul Lichter, Sayoko E Moroi, Anthony Realini, Julia E Richards, Robert Ritch, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Yeunjoo E Song, Douglas Vollrath, Robert Weinreb, Felipe Medeiros, Gadi Wollstein, Donald J Zack, Kang Zhang, Margaret A Pericak-Vance, Pedro Gonzalez, W Daniel Stamer, John Kuchtey, Rachel W Kuchtey, R Rand Allingham, Michael A Hauser, Louis R Pasquale, Jonathan L Haines, Janey L Wiggs
PURPOSE: Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated with primary open-angle glaucoma (POAG). METHODS: Using the NEIGHBORHOOD data set (3853 cases/33,480 controls with European ancestry), we first assessed the relation between 85 variants in 76 MIR genes and overall POAG. Subtype-specific analyses were performed in high-tension glaucoma (HTG) and normal-tension glaucoma subsets...
August 1, 2016: Investigative Ophthalmology & Visual Science
K Stingl, K U Bartz-Schmidt, A Braun, F Gekeler, U Greppmaier, A Schatz, A Stett, T Strasser, V Kitiratschky, E Zrenner
PURPOSE: The subretinal Alpha IMS visual implant is a CE-approved medical device for restoration of visual functions in blind patients with end-stage outer retina degeneration. We present a method to test the function of the implant objectively in vivo using standard electroretinographic equipment and to assess the devices' parameter range for an optimal perception. METHODS: Subretinal implant Alpha IMS (Retina Implant AG, Reutlingen, Germany) consists of 1500 photodiode-amplifier-electrode units and is implanted surgically into the subretinal space in blind retinitis pigmentosa patients...
October 2016: Documenta Ophthalmologica. Advances in Ophthalmology
Tomoko Hasegawa, Yuki Muraoka, Hanako Ohashi Ikeda, Tatsuaki Tsuruyama, Mineo Kondo, Hiroko Terasaki, Akira Kakizuka, Nagahisa Yoshimura
Retinitis pigmentosa (RP) is one of the leading causes of adult blindness and has no established therapy. We have shown that valosin-containing protein (VCP) modulators, Kyoto University Substances (KUSs), ameliorated abnormally low ATP levels by inhibiting the ATPase of VCP, thereby protected several types of cells, including retinal neurons, from cell death-inducing insults. In this study, we found that KUS121, one of the VCP modulators, effectively protects photoreceptors both morphologically and functionally, in two animal models of retinal degeneration, rd12 mice and RP rabbits with a rhodopsin (Pro347Leu) mutation...
2016: Scientific Reports
Erin A Boese, Nieraj Jain, Yali Jia, Catie L Schlechter, Cary O Harding, Simon S Gao, Rachel C Patel, David Huang, Richard G Weleber, Melanie B Gillingham, Mark E Pennesi
PURPOSE: To assess long-term effects of genotype on chorioretinopathy severity in patients with mitochondrial trifunctional protein (MTP) disorders. DESIGN: Retrospective case series. PARTICIPANTS: Consecutive patients with MTP disorders evaluated at a single center from 1994 through 2015, including 18 patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) and 3 patients with trifunctional protein deficiency (TFPD). METHODS: Local records from all visits were reviewed...
October 2016: Ophthalmology
Masaya Haze, Takatoshi Kobayashi, Keigo Kakurai, Hiromi Shoda, Nanae Takai, Sayako Takeda, Rei Tada, Kouichi Maruyama, Teruyo Kida, Tsunehiko Ikeda
PURPOSE: The purpose of this study was to report the case of a patient who underwent vitrectomy for bilateral rhegmatogenous retinal detachment caused by cytomegalovirus (CMV) retinitis while undergoing steroid and immunosuppressant therapy for systemic lupus erythematosus (SLE). CASE REPORT: We report on a 29-year-old female who was undergoing steroids and immunosuppressants treatment for SLE at Osaka Medical College Hospital, Takatsuki City, Japan. Examination of the patient due to prolonged and worsening diarrhea revealed positive test results for C7-HRP, and she was diagnosed with CMV colitis...
May 2016: Case Reports in Ophthalmology
Yi-Ju Ho, Chi-Hsiao Yeh, Chi-Chun Lai, Jerry Chien-Chieh Huang, Lan-Hsin Chuang
BACKGROUND: The aim of this study was to clarify the pathogenic mechanism and to evaluate an intervention for intractable secondary glaucoma in superior vena cava (SVC) syndrome. CASE PRESENTATION: A 66-year-old female with underlying hypertension, diabetes mellitus, ischaemic heart disease and end-stage renal disease complained of bilateral puffy eyelids for 3 months. Over three years, the patient experienced a progressive, marked face and neck swelling, which was accompanied by dyspnoea and nocturnal coughing...
2016: BMC Ophthalmology
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