keyword
MENU ▼
Read by QxMD icon Read
search

Medical retina

keyword
https://www.readbyqxmd.com/read/29772042/subfoveal-choroidal-thickness-as-a-potential-predictor-of-clinical-response-to-stereotactic-radiotherapy-for-neovascular-age-related-macular-degeneration
#1
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
BACKGROUND AND OBJECTIVE: Stereotactic radiotherapy (SRT) is a new adjuvant treatment modality that has been shown to reduce the need for repetitive intravitreal injections (IVIs) in patients with neovascular age-related macular degeneration (nAMD). The authors aimed to determine baseline predictors of clinical response to SRT. PATIENTS AND METHODS: This was a retrospective, observational case series of patients with nAMD who underwent SRT and subsequently had at least 12 months of complete follow-up...
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29770858/-management-of-anticoagulants-in-ophthalmic-surgery-a-survey-among-ophthalmic-surgeons-in-germany
#2
N Feltgen, B Mele, T Dietlein, C Erb, A Eckstein, A Hager, A Heiligenhaus, H Helbig, H Hoerauf, E Hoffmann, D Pauleikhoff, M Schittkowski, B Seitz, C Sucker, S Suffo, U Schaudig, F Tost, S Thurau, P Walter, J Koscielny
INTRODUCTION: As our population ages and comorbidities rise, ophthalmic surgeons are increasingly faced with patients on anticoagulant therapy or with clotting disorders. The ophthalmic surgeon has to weigh the perioperative risk of haemorrhage when anticoagulation continues against the risk of thromboembolism caused by discontinuation or changing the patient's medication (bridging, switching, cessation). There are currently no guidelines or recommendations. METHODS: A survey was sent to the DOG (German Ophthalmologic Society) divisions and associated surgical organizations to determine the status quo...
May 16, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29767982/dentimol-as-a-dendrimeric-timolol-analogue-for-glaucoma-therapy-synthesis-and-preliminary-efficacy-and-safety-assessment
#3
Michael G Lancina, Juan Wang, Geoffrey S Williamson, Hu Yang
In this work, we report synthesis and characterization of DenTimol, a dendrimer-based polymeric timolol analog as glaucoma medication. A timolol precursor (S)-4-[4-(oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine (OTM) was reacted with the heterobifunctional amine polyethylene glycol acetic acid (Amine-PEG-Acetic Acid, Mn=2000 g/mol) via the ring opening reaction of epoxide by an amine to form OTM-PEG conjugate. OTM-PEG was then coupled to ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimer G3 to generate DenTimol using the N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide (NHS) coupling reaction...
May 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29747356/-research-on-the-surgery-treatment-and-etiology-of-fungal-endophthalmitis
#4
H Y Zhou, J J Ye, Y Y Chen, F T Dong
Objective: To evaluate the efficacy of vitrectomy and etiological diagnosis in the treatment of fungal endophthalmitis. Methods: A retrospective survey was done on the clinical manifestation, etiological diagnosis and treatment efficacy of 15 patients (15 eyes) who had been diagnosed with fungal endophthalmitis at the inpatient department of Peking Union Medical College Hospital during 2002-2015. A total of 15 eyes of 15 patients, 3 male and 12 female patients, were included in this study. The mean age of the patients was (45...
April 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29746406/hemi-temporal-internal-limiting-membrane-peeling-is-as-effective-and-safe-as-conventional-full-peeling-for-macular-hole-surgery
#5
Akira Shiono, Jiro Kogo, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Naoto Tokuda, Yasushi Kitaoka, Hitoshi Takagi
PURPOSE: To investigate the efficacy of hemi-temporal internal limiting membrane (ILM) peeling for idiopathic macular hole. METHODS: The medical records of patients with macular holes who had undergone vitrectomy with ILM peeling were studied. Forty-two eyes with macular hole were divided into 2 groups based on surgical procedure (hemi-temporal ILM peeling [hemi group]: 15 eyes; 360° ILM peeling [360° group]: 27 eyes). The closure rates and distances between the optic disc and the intersection of two retinal vessels most closely located nasally or temporally to the macular hole were compared...
May 9, 2018: Retina
https://www.readbyqxmd.com/read/29743491/classical-and-alternative-complement-activation-on-photoreceptor-outer-segments-drives-monocyte-dependent-retinal-atrophy
#6
Kenneth J Katschke, Hongkang Xi, Christian Cox, Tom Truong, Yann Malato, Wyne P Lee, Brent McKenzie, Rommel Arceo, Jianhua Tao, Linda Rangell, Mike Reichelt, Lauri Diehl, Justin Elstrott, Robby M Weimer, Menno van Lookeren Campagne
Geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD), is characterized by progressive loss of retinal pigment epithelium cells and photoreceptors in the setting of characteristic extracellular deposits and remains a serious unmet medical need. While genetic predisposition to AMD is dominated by polymorphisms in complement genes, it remains unclear how complement activation contributes to retinal atrophy. Here we demonstrate that complement is activated on photoreceptor outer segments (POS) in the retina peripheral to atrophic lesions associated with GA...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737971/differential-electrical-responses-in-retinal-ganglion-cell-subtypes-effects-of-synaptic-blockade-and-stimulating-electrode-location
#7
Chih Yu Yang, David Tsai, Tianruo Guo, Socrates Dokos, Gregg J Suaning, John W Morley, Nigel H Lovell
OBJECTIVE: Visual prostheses have shown promising results in restoring visual perception to blind patients. The ability to differentially activate retinal ganglion cell (RGC) subtypes could further improve the efficacy of these medical devices. APPROACH: Using whole-cell patch clamp, we investigated membrane potential differences between ON and OFF RGCs in the mouse retina when their synaptic inputs were blocked by synaptic blockers, and examined the differences in stimulation thresholds under such conditions...
May 8, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29697590/clinical-features-of-lacquer-cracks-in-eyes-with-pathologic-myopia
#8
Xian Xu, Yuxin Fang, Kengo Uramoto, Natsuko Nagaoka, Kosei Shinohara, Tae Yokoi, Noriko Tanaka, Kyoko Ohno-Matsui
PURPOSE: To analyze the morphologic features of lacquer cracks (LCs), compare their detectability by different imaging instruments, and determine their progressive pattern. METHODS: The medical records of 47 highly myopic eyes of 33 patients with LCs were reviewed. Fundus fluorescein angiography was used as the primary method of identifying LCs, and the detection rate was compared with that by fundus autofluorescence and optical coherence tomography. RESULTS: A total of 176 LCs were detected in the 47 eyes...
April 24, 2018: Retina
https://www.readbyqxmd.com/read/29691928/circadian-rhythms-refractive-development-and-myopia
#9
Ranjay Chakraborty, Lisa A Ostrin, Debora L Nickla, P Michael Iuvone, Machelle T Pardue, Richard A Stone
PURPOSE: Despite extensive research, mechanisms regulating postnatal eye growth and those responsible for ametropias are poorly understood. With the marked recent increases in myopia prevalence, robust and biologically-based clinical therapies to normalize refractive development in childhood are needed. Here, we review classic and contemporary literature about how circadian biology might provide clues to develop a framework to improve the understanding of myopia etiology, and possibly lead to rational approaches to ameliorate refractive errors developing in children...
May 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29685778/multifocal-intraocular-lens-implantation-after-previous-hyperopic-corneal-refractive-laser-surgery
#10
Violette Vrijman, Jan Willem van der Linden, Ivanka J E van der Meulen, Maarten P Mourits, Ruth Lapid-Gortzak
PURPOSE: To describe the outcomes in terms of the refraction and visual acuity of multifocal intraocular lens (IOL) implantation in patients with previous hyperopic corneal refractive laser surgery. SETTING: Academic Medical Center, University of Amsterdam, Amsterdam, and Retina Total Eye Care, Driebergen, the Netherlands. DESIGN: Retrospective case series. METHODS: Results were analyzed 3 months after implantation of a multifocal IOL (Acrysof Restor SN6AD1) in patients after previous corneal refractive laser surgery for hyperopia...
April 20, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29676228/glaucoma-pathogenesis-and-neurotrophins-focus-on-the-molecular-and-genetic-basis-for-therapeutic-prospects
#11
Nitin Chitranshi, Yogita Dheer, Mojdeh Abbasi, Yuyi You, Stuart L Graham, Vivek Gupta
BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE: The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29643787/optical-coherence-tomography-angiography-of-foveal-neovascularization-in-diabetic-retinopathy
#12
Konstantinos Andreanos, Tryfon Rotsos, George Kymionis, Chryssanthi Koutsandrea, Athanasios Kotsolis, Ioannis Ladas
Purpose: To report a case of foveal neovascularization in a patient with proliferative diabetic retinopathy as seen on optical coherence tomography angiography (OCT-A). Methods: Multimodal imaging was used for diagnostic investigation. Patient: A 61-year-old male with a 16-year history of insulin-dependent diabetes mellitus was referred to our medical retina department for examination and management. Meticulous fundus examination and multimodal imaging revealed proliferative diabetic retinopathy lesions, including neovascularization located in the foveal area...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29610079/macular-oct-classification-using-a-multi-scale-convolutional-neural-network-ensemble
#13
Reza Rasti, Hossein Rabbani, Alireza Mehridehnavi, Fedra Hajizadeh
Computer-aided diagnosis (CAD) of retinal pathologies is a current active area in medical image analysis. Due to the increasing use of retinal optical coherence tomography (OCT) imaging technique, a CAD system in retinal OCT is essential to assist ophthalmologist in the early detection of ocular diseases and treatment monitoring. This paper presents a novel CAD system based on a multi-scale convolutional mixture of expert (MCME) ensemble model to identify normal retina, and two common types of macular pathologies, namely, dry age-related macular degeneration, and diabetic macular edema...
April 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29609818/reference-3-t-mri-parameters-of-the-normal-human-eye
#14
Laura Fanea
The purpose of this study is to establish magnetic resonance imaging (MRI) standard normative reference quantitative markers for future possible diagnosis in Ophthalmology based on relaxation times (T1 and T2) and retina/choroid complex (RCC) layer thickness values measured in vivo in normal human eyes. This research followed the tenets of the Declaration of Helsinki and was approved by the local Ethical Committee. 15 healthy subjects volunteered to undergo MRI of both eyes. 3 T MRI was performed using a circular surface detector coil with a 15 min acquisition protocol for each eye...
March 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29606853/the-role-of-corneal-hysteresis-during-the-evaluation-of-patients-with-possible-normal-tension-glaucoma
#15
Ming Chen, Laura Kueny, Arthur L Schwartz
Purpose: There are multiple reports of the role of corneal hysteresis (CH) as an independent risk factor for the diagnosis and risk of progression of normal-tension glaucoma (NTG). Our study measured CH with the Ocular Response Analyzer (ORA) in patients with intraocular pressure (IOP) <21 mmHg to investigate if a low CH would identify NTG in this Asian-based practice. Methods: This was a prospective cross-sectional study of patients who underwent routine eye examination during 2016 in a private practice in Honolulu, Hawaii, where most patients are Asian...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29582545/viscoelastic-properties-of-the-posterior-eye-of-normal-subjects-patients-with-age-related-macular-degeneration-and-pigs
#16
ZhenHuan Zhang, MengXin Pan, JiaTong Cai, James D Weiland, Kinon Chen
The purpose of this study is to measure, characterize, and compare the viscoelastic properties of the posterior eye of advanced dry age-related macular degeneration (AMD) patients, age-matched normal subjects, and pigs (3 groups). Ten horizontal and ten vertical strips of the macula retina and the underneath choroid and sclera were obtained for each group, respectively. They were examined by incremental stress-relaxation cycles in body-temperature saline. Mechanical response was characterized by the quasi-linear viscoelastic model...
March 26, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29576452/ipscs-from-a-hibernator-provide-a-platform-for-studying-cold-adaptation-and-its-potential-medical-applications
#17
Jingxing Ou, John M Ball, Yizhao Luan, Tantai Zhao, Kiyoharu J Miyagishima, Yufeng Xu, Huizhi Zhou, Jinguo Chen, Dana K Merriman, Zhi Xie, Barbara S Mallon, Wei Li
Hibernating mammals survive hypothermia (<10°C) without injury, a remarkable feat of cellular preservation that bears significance for potential medical applications. However, mechanisms imparting cold resistance, such as cytoskeleton stability, remain elusive. Using the first iPSC line from a hibernating mammal (13-lined ground squirrel), we uncovered cellular pathways critical for cold tolerance. Comparison between human and ground squirrel iPSC-derived neurons revealed differential mitochondrial and protein quality control responses to cold...
March 20, 2018: Cell
https://www.readbyqxmd.com/read/29575612/assessment-of-the-metabolism-and-morphology-of-the-porcine-cornea-lens-and-retina-by-two-photon-imaging
#18
Ana Batista, Hans Georg Breunig, Aisada König, António Miguel Morgado, Karsten König
Two-photon imaging is a non-invasive imaging technique with increasing importance in the biological and medical fields since it allows intratissue cell imaging with high resolution. We demonstrate the feasibility of using a single two-photon instrument to evaluate the cornea, the crystalline lens, and the retina based on their autofluorescence. Image acquisition was performed using a custom-built two-photon microscope for 5D microscopy with a near infrared broadband sub-15 femtosecond laser centered at 800 nm...
March 25, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29558906/a-white-membrane-beneath-the-inner-limiting-membrane-of-the-retina-in-a-4-year-old-child-with-ultrastructural-evidence-a-case-report
#19
Wenyi Tang, Ruiping Gu, Ting Zhang, Gezhi Xu
BACKGROUND: Epiretinal membranes (ERMs), secondary to retinal cell proliferation on the retinal surface, usually affect patients over 50 years of age but occur rarely in children. Here we report the case of a 4-year-old patient with a unilateral sub-inner limiting membrane (sub-ILM) membrane mimicking epiretinal membrane with notable ultrastructural features indicating its possible origin from old sub-ILM hemorrhage. CASE PRESENTATION: A 4-year-old boy was admitted with the complaint of poor vision in his right eye, which had been detected at school vision screening performed 6 months earlier...
March 20, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29554054/cefalium-induced-bilateral-transient-myopia-retinal-folds-and-focal-choroidal-delay
#20
Luís Augusto Arana, Mariana Bolzani Bach, Gustavo Vedana, Mathias Alexandre Volkmann, Jayme Arana
PURPOSE: To describe a case of acute bilateral transient myopia, retinal folds, and island of choroidal delay associated with oral administration of Cefalium, a medication commonly prescribed in Brazil for migraine that combines acetaminophen 500 mg, caffeine 40 mg, dihydroergotamine mesylate 1 mg, and metoclopramide hydrochloride 10 mg. METHODS: A 21-year-old woman with bilateral blurred vision 1 day after the use of Cefalium. The main outcomes measures were BCVA, ocular fundus, ocular coherence tomography, and angiography findings...
April 2018: Retinal Cases & Brief Reports
keyword
keyword
29776
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"