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https://www.readbyqxmd.com/read/29152163/effect-of-aging-and-lifestyle-on-photoreceptors-and-retinal-pigment-epithelium-cross-sectional-study-in-a-healthy-danish-population
#1
Jacob Harris, Yousif Subhi, Torben L Sørensen
Photoreceptors and their supporting retinal pigment epithelium constitute the key functional parts of the retina. Here, a study was undertaken to show how aging and lifestyle factors affect the photoreceptor layer and the retinal pigment epithelium and Bruch's membrane complex (RPE-BM) in vivo in a healthy Danish population using spectral-domain optical coherence tomography. This was a cross-sectional study of healthy humans aged ≥50 years. All participants were interviewed for medical history and lifestyle factors...
2017: Pathobiology of Aging & Age related Diseases
https://www.readbyqxmd.com/read/29148158/long-term-anesthetic-protocol-in-rats-feasibility-in-electrophysiology-studies-in-visual-prosthesis
#2
Alejandro Barriga-Rivera, Veronica Tatarinoff, Nigel H Lovell, John W Morley, Gregg J Suaning
Electrical stimulation of excitable cells provides therapeutic benefits for a variety of medical conditions, including restoration of partial vision to those blinded via some types of retinal degeneration. To improve visual percepts elicited by the current technology, researchers are conducting acute electrophysiology experiments, mainly in cats. However, the rat can provide a model of a range of retinal diseases and possesses a sufficiently large eye to be used in this field. This article presents a long-term anesthetic protocol to enable electrophysiology experiments to further the development of visual prostheses...
November 17, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29147565/operating-room-central-serous-chorioretinopathy
#3
Ahmad M Mansour, Rola Hamam
Objectives: The operating room is a place of surgical intervention with its accompanying bodily and cognitive strain on the performers. Stress in the operating room may lead to the onset of central serous chorioretinopathy as reported hereby in a retina surgeon and is labeled as operating room central serous chorioretinopathy. Methods: The same operator performed the optical coherence tomography scans on one retina surgeon. A masked observer estimated the maximal height of the subretinal fluid...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/29132616/imperceptible-watermarking-for-security-of-fundus-images-in-tele-ophthalmology-applications-and-computer-aided-diagnosis-of-retina-diseases
#4
Anushikha Singh, Malay Kishore Dutta
BACKGROUND AND OBJECTIVES: The authentication and integrity verification of medical images is a critical and growing issue for patients in e-health services. Accurate identification of medical images and patient verification is an essential requirement to prevent error in medical diagnosis. The proposed work presents an imperceptible watermarking system to address the security issue of medical fundus images for tele-ophthalmology applications and computer aided automated diagnosis of retinal diseases...
December 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29127485/oct-based-deep-learning-algorithm-for-the-evaluation-of-treatment-indication-with-anti-vascular-endothelial-growth-factor-medications
#5
Philipp Prahs, Viola Radeck, Christian Mayer, Yordan Cvetkov, Nadezhda Cvetkova, Horst Helbig, David Märker
PURPOSE: Intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF) medications have become the standard of care for their respective indications. Optical coherence tomography (OCT) scans of the central retina provide detailed anatomical data and are widely used by clinicians in the decision-making process of anti-VEGF indication. In recent years, significant progress has been made in artificial intelligence and computer vision research. We trained a deep convolutional artificial neural network to predict treatment indication based on central retinal OCT scans without human intervention...
November 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29121363/treatment-of-ipilimumab-induced-vogt-koyanagi-harada-syndrome-with-oral-dexamethasone
#6
Matthew T Witmer
The author presents a retrospective case report of a 54-year-old male with ipilimumab (Yervoy; Bristol-Myers Squibb, New York City, NY)-induced Vogt-Koyanagi-Harada Disease (VKH), which consisted of uveitis, optic neuritis, and choroiditis that was successfully treated with oral dexamethasone. The patient demonstrated resolution of uveitis, optic neuritis, and choroiditis 1 month following initiation of oral dexamethasone. Ipilimumab is a recently approved therapy for malignant melanoma. Reports have identified that VKH disease is a potential side effect of the medication...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29121361/valved-25-gauge-cannula-for-vitreous-tap-and-injection
#7
Theodore Leng, Darius M Moshfeghi
BACKGROUND AND OBJECTIVES: To describe a technique that reduces patient discomfort by using a valved 25-gauge trocar for vitreous tap and intravitreal injection of medications in previously vitrectomized eyes with suspected infectious endophthalmitis. PATIENTS AND METHODS: A commercially available 25-gauge valved entry system is used to enter the vitreous cavity. A 25-gauge needle attached to a syringe is used to obtain a vitreous specimen for microbiological access and administer intravitreal injections of antibiotics and steroids...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29101498/surgical-treatments-for-fibrous-tissue-extending-to-the-posterior-retina-in-eyes-with-familial-exudative-vitreoretinopathy
#8
Mari Takahashi, Tadashi Yokoi, Satoshi Katagiri, Tomoyo Yoshida-Uemura, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To describe the clinical features and surgical outcomes of macular dragging or tractional retinal detachment that occurred as a result of fibrovascular tissue (FT) progression toward the posterior retina in eyes with familial exudative vitreoretinopathy (FEVR). METHODS: The medical records of 4 patients (2 girls, 2 boys) with FEVR were reviewed retrospectively. RESULTS: All 4 patients had retinal dragging or radial retinal folds with FT in the peripheral retina in at least 1 eye at the initial visit...
November 3, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29095872/multi-categorical-deep-learning-neural-network-to-classify-retinal-images-a-pilot-study-employing-small-database
#9
Joon Yul Choi, Tae Keun Yoo, Jeong Gi Seo, Jiyong Kwak, Terry Taewoong Um, Tyler Hyungtaek Rim
Deep learning emerges as a powerful tool for analyzing medical images. Retinal disease detection by using computer-aided diagnosis from fundus image has emerged as a new method. We applied deep learning convolutional neural network by using MatConvNet for an automated detection of multiple retinal diseases with fundus photographs involved in STructured Analysis of the REtina (STARE) database. Dataset was built by expanding data on 10 categories, including normal retina and nine retinal diseases. The optimal outcomes were acquired by using a random forest transfer learning based on VGG-19 architecture...
2017: PloS One
https://www.readbyqxmd.com/read/29075777/quantitative-autofluorescence-intensities-in-acute-zonal-occult-outer-retinopathy-vs-healthy-eyes
#10
Katherine Boudreault, Kaspar Schuerch, Jin Zhao, Winston Lee, Thiago Cabral, Lawrence A Yannuzzi, Stephen H Tsang, Janet R Sparrow
Importance: Acute zonal occult outer retinopathy (AZOOR) remains a challenging diagnosis. Early recognition of the disease depends on advances in imaging modalities that can improve phenotyping and contribute to the understanding of the underlying pathogenesis. Objectives: To expand the range of approaches available to assist in the identification of AZOOR by multimodal imaging and to analyze the fundus lesions by quantifying short-wavelength fundus autofluorescence (quantitative fundus autofluorescence [qAF]) and spectral-domain optical coherence tomography...
October 26, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29060096/assisting-people-with-nystagmus-through-image-stabilization-using-an-arx-model-to-overcome-processing-delays
#11
Stephan Polzer, Klaus Miesenberger
Pathological Nystagmus is characterized by an unintended and involuntary eye-movement, which tends to impact on visual acuity. Today only view therapies (for instance medication or surgeries) to treat nystagmus are at hand and the existing therapies only show partial improvement. Only general Assistive Technology (AT) solutions like glasses, screen magnifiers, speech output, display adaptation and concepts holders are at hand to support daily living. More specific ATs to reduce the impact of nystagmus are missing...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29058245/ocular-findings-in-a-patient-with-oculofaciocardiodental-ofcd-syndrome-and-a-novel-bcor-pathogenic-variant
#12
Yujia Zhou, Antonina Wojcik, Victoria R Sanders, Bahram Rahmani, Sudhi P Kurup
PURPOSE: To report a case of OFCD associated with a de novo BCOR pathogenic variant and highlight the ocular findings and possible mechanisms. METHODS: A retrospective chart review of the patient's ocular and systemic findings was performed. The patient underwent diagnostic whole exome sequencing (WES). RESULTS: The patient had a comprehensive eye exam in infancy demonstrating bilateral congenital cataracts consisting of posterior lenticonus with a posterior cortical opacity...
October 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29055730/-management-of-wet-amd-in-france-in-2015
#13
J Zerbib, A Bourhis, P L Cornut, F De Bats, V Gualino, J Halfon, H Massé, M Srour, M Streho, S Tick, B Wolff, N San Nicolas
PURPOSE AND CONTEXT: Intravitreal administration of anti-VEGF agents, available in France since 2007, allows stabilization and improvement in visual acuity in wet age-related macular degeneration (AMD). In the past few years, the management of this disease has evolved in terms of both diagnostic methods and treatment schedules, which have been adapted to the pathophysiology of AMD. The goal of this survey, performed in a representative sample of French ophthalmologists, was to describe the evolution of medical practices one year after a similar survey (Massé et al...
November 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29050924/-progression-of-nerve-fiber-layer-defects-in-retrobulbar-optic-neuritis-by-the-macular-ganglion-cell-complex
#14
D Hong, C Bosc, F Chiambaretta
INTRODUCTION: Recent studies with SD OCT had shown early axonal damage to the macular ganglion cell complex (which consists of the three innermost layers of the retina: Inner Plexiform Layer [IPL], Ganglion Cell Layer [GCL], Retinal Nerve Fibre layer [RNFL]) in optic nerve pathology. Retrobulbar optic neuritis (RBON), occurring frequently in demyelinating diseases, leads to atrophy of the optic nerve fibers at the level of the ganglion cell axons, previously described in the literature...
November 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29050185/-optical-coherence-tomography-angiography-of-acute-vogt-koyanagi-harada-disease
#15
S S Jia, C Zhao, D Gong, Z Chen, M F Zhang
Objective: To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). Methods: This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044067/improvement-in-distance-and-near-visual-acuities-using-low-vision-devices-in-diabetic-retinopathy
#16
Sarika Gopalakrishnan, Aishwarya Muralidharan, Shwetha Chambayil Susheel, Rajiv Raman
PURPOSE: The aim of this study is to elucidate the causes and level of visual impairment (VI) in patients with different pathologies of diabetic retinopathy (DR) who presented to a low vision care (LVC) clinic, to analyze the type of distant and near devices prescribed to them and the visual benefits thereof. METHODS: A retrospective chart review was done for 100 consecutive patients with DR who were referred to the LVC clinic from June 2015 to June 2016. The reason for referral was assessed from the electronic medical records and available fundus photographs, fundus fluorescein angiograms, and optical coherence tomography images by a retina specialist...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29033824/optical-coherence-tomography-evolution-in-a-case-of-x-linked-juvenile-retinoschisis-15-years-of-follow-up
#17
Irini Chatziralli, George Theodossiadis, Dimitrios Brouzas, Ioannis Emfietzoglou, Panagiotis Theodossiadis
PURPOSE: We present the evolution of X-linked juvenile retinoschisis (XLRS) in a male patient using optical coherence tomography (OCT) with a long-term follow-up time of 15 years. CASE DESCRIPTION: A 10-year-old male patient presented at the Medical Retina Department of our hospital complaining for blurred vision in both eyes. At the initial presentation in 2001, his best corrected visual acuity (BCVA) was 6/12 in both eyes on the Snellen chart. Based on clinical and OCT findings, the diagnosis of XLRS was made, and it was confirmed by genetic testing...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29016457/optical-coherence-tomography-angiography-in-geographic-atrophy
#18
Riccardo Sacconi, Eleonora Corbelli, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To analyze choriocapillaris (CC) vessel density (VD) around geographic atrophy (GA) secondary to non-neovascular dry age-related macular degeneration using optical coherence tomography angiography. METHODS: We compared CC VD surrounding GA margin (500 μm radius) with control CC (outside GA margin) in a consecutive series of GA patients presenting between August 2016 and February 2017 at the Medical Retina and Imaging Unit of University Vita-Salute, IRCCS Ospedale San Raffaele in Milan...
October 6, 2017: Retina
https://www.readbyqxmd.com/read/28980567/-diagnostic-imaging-for-sclerochoroidal-calcifica-tion
#19
A S Stoyukhina
The article presents two clinical cases of sclerochoroidal calcification. This is a rare benign condition that usually does not display itself and is only occasionally diagnosed. It can also be accompanied by systemic disorder of mineral metabolism. The data obtained through medical imaging indicate partial destruction of the choroid at the site of the damage that causes secondary changes in the overlying retina.
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28975766/changes-in-thickness-of-central-macula-and-retinal-nerve-fibre-layer-in-severe-hypertensive-retinopathy-a-1-year-longitudinal-study
#20
Han-Min Lee, Woo-Hyuk Lee, Kyong Nam Kim, Young Joon Jo, Jung Yeul Kim
OBJECTIVE: To analyse the longitudinal changes in the thickness of the central macula and retinal nerve fibre layer (RNFL) in patients with hypertensive retinopathy (HTNR) using spectral-domain optical coherence tomography (SD-OCT). METHODS: This was a prospective cohort study. We studied 18 eyes of patients with HTNR of grade IV who had been followed up for more than 1 year, and 36 normal eyes (without any relevant medical history; the control group). Antihypertensive treatment successfully normalized the blood pressure of HTNR patients...
October 4, 2017: Acta Ophthalmologica
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