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Viral hemorrhagic fever

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https://www.readbyqxmd.com/read/28318633/capillary-leak-syndrome-etiologies-pathophysiology-and-management
#1
REVIEW
Eric Siddall, Minesh Khatri, Jai Radhakrishnan
In various human diseases, an increase in capillary permeability to proteins leads to the loss of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the disease most commonly associated with this phenomenon, many other diseases can lead to a "sepsis-like" syndrome with manifestations of diffuse pitting edema, exudative serous cavity effusions, noncardiogenic pulmonary edema, hypotension, and, in some cases, hypovolemic shock with multiple-organ failure. The term capillary leak syndrome has been used to describe this constellation of disease manifestations associated with an increased capillary permeability to proteins...
March 16, 2017: Kidney International
https://www.readbyqxmd.com/read/28317453/ebola-virus-epidemiology-diagnosis-and-control-threat-to-humans-lessons-learnt-and-preparedness-plans-an-update-on-its-40-year-s-journey
#2
Raj Kumar Singh, Kuldeep Dhama, Yashpal Singh Malik, Muthannan Andavar Ramakrishnan, Kumaragurubaran Karthik, Rekha Khandia, Ruchi Tiwari, Ashok Munjal, Mani Saminathan, Swati Sachan, Perumal Arumugam Desingu, Jobin Jose Kattoor, Hafiz M N Iqbal, Sunil Kumar Joshi
Ebola virus (EBOV) is an extremely contagious pathogen and causes lethal hemorrhagic fever disease in man and animals with high fatality rates. The recently occurred Ebola virus disease (EVD) outbreaks in the West African countries have categorized it as an international health concern. For the virus maintenance and transmission, the non-human primates and reservoir hosts like fruit bats have played a vital role. Furthermore, the virus may also get transferred through contaminated biological fluids like breast milk, tears, urine, semen, blood, etc...
March 20, 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28316015/expression-and-characterization-of-codon-optimized-crimean-congo-hemorrhagic-fever-virus-gn-glycoprotein-in-insect-cells
#3
Mehdi Rahpeyma, Alireza Samarbaf-Zadeh, Manoochehr Makvandi, Ata A Ghadiri, Stuart D Dowall, Fatemeh Fotouhi
Crimean-Congo hemorrhagic fever virus (CCHFV) is a major cause of tick-borne viral hemorrhagic disease in the world. Despite of its importance as a deadly pathogen, there is currently no licensed vaccine against CCHF disease. The attachment glycoprotein of CCHFV (Gn) is a potentially important target for protective antiviral immune responses. To characterize the expression of recombinant CCHFV Gn in an insect-cell-based system, we developed a gene expression system expressing the full-length coding sequence under a polyhedron promoter in Sf9 cells using recombinant baculovirus...
March 18, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28292653/co-circulating-serotypes-in-a-dengue-fever-outbreak-differential-hematological-profiles-and-phylogenetic-relationships-among-viruses
#4
Andreia Moreira Dos Santos Carmo, Rodrigo Buzinaro Suzuki, Aline Diniz Cabral, Renata Torres da Costa, Gabriela Pena Massari, Michele Marcondes Riquena, Helio Augusto Alves Fracasso, Andre Eterovic, Arlei Marcili, Márcia Aparecida Sperança
BACKGROUND: Dengue virus, represented by four distinct, genetically diverse serotypes, is the etiologic agent of asymptomatic to severe hemorrhagic diseases. The spatiotemporal dynamics of dengue serotypes and its association to specific diseases vary among the different regions worldwide. By 2007, and in São Paulo State, Brazil, dengue-case concentration in urban centers had changed to increased incidence in small- and medium-sized towns, the case of Marília. OBJECTIVES: The aim of this article was to distinguish dengue serotypes circulating during the 2007 Marília outbreak and define their association to demographic and hematological patient profiles, as well as the phylogenetic relationships among the different viruses...
March 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28291670/molecular-ticks-and-serological-humans-study-of-crimean-congo-hemorrhagic-fever-virus-in-the-iberian-peninsula-2013-2015
#5
Ana M Palomar, Aránzazu Portillo, Sonia Santibáñez, Lara García-Álvarez, Agustín Muñoz-Sanz, Francisco J Márquez, Lourdes Romero, José M Eiros, José A Oteo
INTRODUCTION: Crimean-Congo hemorrhagic fever (CCHF) is a viral disease, mainly transmitted through tick bite, of great importance in Public Health. In Spain, Crimean-Congo hemorrhagic fever virus (CCHFV) was detected for the first time in 2010 in Hyalomma lusitanicum ticks collected from deer in Cáceres. The aim of this study was to investigate the presence of CCHFV in ticks from Cáceres, and from other Spanish areas, and to evaluate the presence of antibodies against the virus in individuals exposed to tick bites...
March 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28290554/the-core-protein-of-a-pestivirus-protects-the-incoming-virus-against-ifn-induced-effectors
#6
Christiane Riedel, Benjamin Lamp, Benedikt Hagen, Stanislav Indik, Till Rümenapf
A multitude of viral factors - either inhibiting the induction of the IFN-system or its effectors - have been described to date. However, little is known about the role of structural components of the incoming virus particle in protecting against IFN-induced antiviral factors during or immediately after entry. In this study, we take advantage of the previously reported property of Classical swine fever virus (family Flaviviridae, genus Pestivirus) to tolerate a deletion of the core protein if a compensatory mutation is present in the NS3-helicase-domain (Vp447∆c)...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28280713/stevens-johnson-syndrome-and-abuse-of-anabolic-steroids
#7
Serena Cocca, Massimo Viviano
Stevens-Johnson syndrome (SJS) is characterized by mucocutaneous tenderness and typical hemorrhagic erosions, erythema and epidermal detachment presenting as blisters and areas of denuded skin. SJS is often observed after drug use as well as after bacterial or viral infections. Several drugs are at high risk of inducing SJS, but there are no cases in the English literature regarding anabolic steroid use triggering SJS. In our paper, we describe a case in which use of anabolic androgenic steroids (AAS) was associated with SJS...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28273071/ethnic-groups-knowledge-attitude-and-practices-and-rift-valley-fever-exposure-in-isiolo-county-of-kenya
#8
Hippolyte Affognon, Peter Mburu, Osama Ahmed Hassan, Sarah Kingori, Clas Ahlm, Rosemary Sang, Magnus Evander
Rift Valley fever (RVF) is an emerging mosquito-borne viral hemorrhagic fever in Africa and the Arabian Peninsula, affecting humans and livestock. For spread of infectious diseases, including RVF, knowledge, attitude and practices play an important role, and the understanding of the influence of behavior is crucial to improve prevention and control efforts. The objective of the study was to assess RVF exposure, in a multiethnic region in Kenya known to experience RVF outbreaks, from the behavior perspective...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28259724/current-status-of-crimean-congo-hemorrhagic-fever-in-who-eastern-mediterranean-region-issues-challenges-and-future-directions
#9
REVIEW
Seif S Al-Abri, Idris Al Abaidani, Mehdi Fazlalipour, Ehsan Mostafavi, Hakan Leblebicioglu, Natalia Pshenichnaya, Ziad A Memishemish, Roger Hewson, Jorgen Eskild Petersen, Peter Mala, Tran Minh Nhu Nguyen, Mamunur Rahman Malik, Pierre Formenty, Rosanna Lucy Jeffries
Crimean-Congo hemorrhagic fever (CCHF) is the most wide-spread, tick-borne viral disease affecting humans. The disease is endemic in many regions such as Africa, Asia, Eastern and Southern Europe, and Central Asia. Recently, the incidence of CCHF has increased rapidly in the countries of the Eastern Mediterranean Region of the World Health Organization (WHO), with sporadic human cases and outbreaks of CCHF being reported from a number of countries in the region. Despite the rapidly growing incidence of the disease, there is currently no accurate data on the burden of the disease in the region due to different surveillance systems for CCHF in the countries...
March 1, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28250262/increased-irisin-concentrations-in-patients-with-crimean-congo-hemorragic-fever
#10
Seyit Ali Büyüktuna, Halef Okan Doğan, Deniz Bakır, Serpil Erşan, Derya Koç, Sevtap Bakır
Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening viral infection. The pathogenesis of the disease is not well understood. The aim of this study was to determine the change in irisin concentrations in patients with CCHF. The study included a total of 30 patients with CCHF and 30 control subjects. Irisin concentrations were determined using a commercial ELISA kit. Median irisin concentrations were 9.03 (5.81-12.22) µg/mL and 4,.2 (3.39-7.62) µg/mL , respectively. There was no correlation between irisin and disease severity...
February 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28250127/attenuated-human-parainfluenza-virus-type-1-expressing-ebola-virus-glycoprotein-gp-administered-intranasally-is-immunogenic-in-african-green-monkeys
#11
Matthias Lingemann, Xueqiao Liu, Sonja Surman, Bo Liang, Richard Herbert, Ashley D Hackenberg, Ursula J Buchholz, Peter L Collins, Shirin Munir
The recent 2014-2016 Ebola virus (EBOV) outbreak prompted increased efforts to develop vaccines against EBOV disease. We describe the development and preclinical evaluation of an attenuated recombinant human parainfluenza virus type 1 (rHPIV1) expressing the membrane-anchored form of EBOV glycoprotein GP, as an intranasal (IN) EBOV vaccine. GP was codon optimized and expressed either as a full-length protein or an engineered chimeric form in which its transmembrane and cytoplasmic tail (TMCT) domains were substituted with those of the HPIV1 F protein in an effort to enhance packaging into the vector particle and immunogenicity...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28249811/crimean-congo-hemorrhagic-fever-in-pregnancy-a-systematic-review-and-case-series-from-russia-kazakhstan-and-turkey
#12
Natalia Yurievna Pshenichnaya, Hakan Leblebicioglu, Ilkay Bozkurt, Irina Viktorovna Sannikova, Gulzhan Narkenovna Abuova, Andrey Sergeevich Zhuravlev, Sener Barut, Mutabar Bekovna Shermetova, Tom E Fletcher
BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) is acute viral infection and a major emerging infectious diseases threat, affecting a large geographical area. There is no proven antiviral therapy and it has a case fatality rate of 4-30%. The natural history of disease and outcomes of CCHF in pregnant women is poorly understood. OBJECTIVES: To systematically review the characteristics of CCHF in pregnancy, and report a case series of 8 CCHF cases in pregnant women from Russia, Kazakhstan and Turkey...
February 26, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28243938/hemorrhagic-fever-of-bunyavirus-etiology-disease-models-and-progress-towards-new-therapies
#13
REVIEW
Brian B Gowen, Brady T Hickerson
A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use...
March 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28238876/ar-12-suppresses-dengue-virus-replication-by-down-regulation-of-pi3k-akt-and-grp78
#14
Hsin-Hsin Chen, Chien-Chin Chen, Yee-Shin Lin, Chiou-Feng Lin, Chia-Ling Chen, Chih-Peng Chang
Dengue virus (DENV) infection has become a public health issue of worldwide concern and is a serious health problem in Taiwan, yet there are no approved effective antiviral drugs to treat DENV. The replication of DENV requires both viral and cellular factors. Owing to the rapid mutation rate of viral factors, targeting host factors may serve as a more promising antiviral strategy. It has been known that up-regulation of PI3K/AKT signaling and GRP78 by DENV infection supports its replication. AR-12, a phase I trial completed anticancer drug, shows potent inhibitory activities on both PI3K/AKT signaling and GRP78 expression levels, and recently has been found to block the replication of several hemorrhagic fever viruses...
February 23, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28216208/a-rare-case-of-pediatric-lumbar-spinal-ependymoma-mimicking-meningitis
#15
Ezeali Mike Ekuma, Kiyoshi Ito, Akihiro Chiba, Yosuke Hara, Kohei Kanaya, Tetsuyoshi Horiuchi, Samuel Ohaegbulam, Kazuhiro Hongo
Spontaneous acute subarachnoid hemorrhage (SAH) from lumbar ependymoma in children is rare. We report a case of a14-year-old boy who developed sudden radicular low back pain while playing baseball. He was initially managed conservatively in a local hospital for suspected lumbar disc herniation, but later developed meningeal symptoms and fever before being referred to our hospital. There he underwent a diagnostic lumbar puncture in the emergency room; his cerebrospinal fluid suggested an SAH. Physical examination showed meningeal signs and cauda equina features...
February 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28207905/the-one-health-approach-to-identify-knowledge-attitudes-and-practices-that-affect-community-involvement-in-the-control-of-rift-valley-fever-outbreaks
#16
Osama Ahmed Hassan, Hippolyte Affognon, Joacim Rocklöv, Peter Mburu, Rosemary Sang, Clas Ahlm, Magnus Evander
Rift Valley fever (RVF) is a viral mosquito-borne disease with the potential for global expansion, causes hemorrhagic fever, and has a high case fatality rate in young animals and in humans. Using a cross-sectional community-based study design, we investigated the knowledge, attitudes and practices of people living in small village in Sudan with respect to RVF outbreaks. A special One Health questionnaire was developed to compile data from 235 heads of household concerning their knowledge, attitudes, and practices with regard to controlling RVF...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28196318/common-skin-conditions-in-children-skin-infections
#17
Brian Z Rayala, Dean S Morrell
Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Recognition of their common and atypical presentations is necessary to differentiate them from other skin conditions of similar morphology. Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194457/disposable-cartridge-platform-for-rapid-detection-of-viral-hemorrhagic-fever-viruses
#18
Steven M Scherr, David S Freedman, Krystle N Agans, Alexandru Rosca, Erik Carter, Melody Kuroda, Helen E Fawcett, Chad E Mire, Thomas W Geisbert, M Selim Ünlü, John H Connor
Light microscopy is a straightforward and highly portable imaging approach that is used for the detection of parasites, fungi, and bacteria. The detection of individual virus particles has historically not been possible through this approach. Thus, characterization of virus particles is typically performed using high-energy approaches such as electron microscopy. These approaches require purification of virions away from its normal milieu, significant levels of expertise, and only count a small number of particles at a time...
February 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28192094/filovirus-proteins-for-antiviral-drug-discovery-structure-function-bases-of-the-replication-cycle
#19
REVIEW
Baptiste Martin, Bruno Canard, Etienne Decroly
Filoviruses are important pathogens that cause severe and often fatal hemorrhagic fever in humans, for which no approved vaccines and antiviral treatments are yet available. In an earlier article (Martin et al., Antiviral Research, 2016), we reviewed the role of the filovirus surface glycoprotein in replication and as a target for drugs and vaccines. In this review, we focus on recent findings on the filovirus replication machinery and how they could be used for the identification of new therapeutic targets and the development of new antiviral compounds...
February 10, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28192064/aedes-borne-virus-mosquito-interactions-mass-spectrometry-strategies-and-findings
#20
Victoria Pando-Robles, Cesar V Batista
Aedes-borne viruses are responsible for high-impact neglected tropical diseases and unpredictable outbreaks such as the ongoing Zika epidemics. Aedes mosquitoes spread different arboviruses such as Dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus, among others, and are responsible for the continuous emergence and reemergence of these pathogens. These viruses have complex transmission cycles that include two hosts, namely the Aedes mosquito as a vector and susceptible vertebrate hosts. Human infection with arboviruses causes diseases that range from subclinical or mild to febrile diseases, encephalitis, and hemorrhagic fever...
February 13, 2017: Vector Borne and Zoonotic Diseases
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