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Viral hemorrhagic fever

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https://www.readbyqxmd.com/read/28216208/a-rare-case-of-pediatric-lumbar-spinal-ependymoma-mimicking-meningitis
#1
Ezeali Mike Ekuma, Kiyoshi Ito, Akihiro Chiba, Yosuke Hara, Kohei Kanaya, Tetsuyoshi Horiuchi, Samuel Ohaegbulam, Kazuhiro Hongo
Spontaneous acute subarachnoid hemorrhage (SAH) from lumbar ependymoma in children is rare. We report a case of a14-year-old boy who developed sudden radicular low back pain while playing baseball. He was initially managed conservatively in a local hospital for suspected lumbar disc herniation, but later developed meningeal symptoms and fever before being referred to our hospital. There he underwent a diagnostic lumbar puncture in the emergency room; his cerebrospinal fluid suggested an SAH. Physical examination showed meningeal signs and cauda equina features...
February 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28207905/the-one-health-approach-to-identify-knowledge-attitudes-and-practices-that-affect-community-involvement-in-the-control-of-rift-valley-fever-outbreaks
#2
Osama Ahmed Hassan, Hippolyte Affognon, Joacim Rocklöv, Peter Mburu, Rosemary Sang, Clas Ahlm, Magnus Evander
Rift Valley fever (RVF) is a viral mosquito-borne disease with the potential for global expansion, causes hemorrhagic fever, and has a high case fatality rate in young animals and in humans. Using a cross-sectional community-based study design, we investigated the knowledge, attitudes and practices of people living in small village in Sudan with respect to RVF outbreaks. A special One Health questionnaire was developed to compile data from 235 heads of household concerning their knowledge, attitudes, and practices with regard to controlling RVF...
February 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28196318/common-skin-conditions-in-children-skin-infections
#3
Brian Z Rayala, Dean S Morrell
Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Recognition of their common and atypical presentations is necessary to differentiate them from other skin conditions of similar morphology. Impetigo, cellulitis, and abscess comprise the majority of childhood bacterial skin infections and are treated with topical or systemic antibiotics that cover group A Streptococcus and Staphylococcus aureus...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28194457/disposable-cartridge-platform-for-rapid-detection-of-viral-hemorrhagic-fever-viruses
#4
Steven M Scherr, David S Freedman, Krystle N Agans, Alexandru Rosca, Erik Carter, Melody Kuroda, Helen E Fawcett, Chad E Mire, Thomas W Geisbert, M Selim Ünlü, John H Connor
Light microscopy is a straightforward and highly portable imaging approach that is used for the detection of parasites, fungi, and bacteria. The detection of individual virus particles has historically not been possible through this approach. Thus, characterization of virus particles is typically performed using high-energy approaches such as electron microscopy. These approaches require purification of virions away from its normal milieu, significant levels of expertise, and only count a small number of particles at a time...
February 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28192094/filovirus-proteins-for-antiviral-drug-discovery-structure-function-bases-of-the-replication-cycle
#5
REVIEW
Baptiste Martin, Bruno Canard, Etienne Decroly
Filoviruses are important pathogens that cause severe and often fatal hemorrhagic fever in humans, for which no approved vaccines and antiviral treatments are yet available. In an earlier article (Martin et al., Antiviral Research, 2016), we reviewed the role of the filovirus surface glycoprotein in replication and as a target for drugs and vaccines. In this review, we focus on recent findings on the filovirus replication machinery and how they could be used for the identification of new therapeutic targets and the development of new antiviral compounds...
February 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28192064/aedes-borne-virus-mosquito-interactions-mass-spectrometry-strategies-and-findings
#6
Victoria Pando-Robles, Cesar V Batista
Aedes-borne viruses are responsible for high-impact neglected tropical diseases and unpredictable outbreaks such as the ongoing Zika epidemics. Aedes mosquitoes spread different arboviruses such as Dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus, among others, and are responsible for the continuous emergence and reemergence of these pathogens. These viruses have complex transmission cycles that include two hosts, namely the Aedes mosquito as a vector and susceptible vertebrate hosts. Human infection with arboviruses causes diseases that range from subclinical or mild to febrile diseases, encephalitis, and hemorrhagic fever...
February 13, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28192052/preparedness-at-japan-s-hospitals-designated-for-patients-with-highly-infectious-diseases
#7
Takao Toyokawa, Narumi Hori, Yasuyuki Kato
In 2015, in order to assess the preparedness of Japan's special hospitals that have been designated to admit and treat patients with highly infectious diseases, we conducted a cross-sectional study of all 47 hospitals with this designation, using a self-report questionnaire that addressed 5 issues: (1) hospital characteristics and the occupation of the respondents; (2) the availability and content of the hospital guidelines for managing patients with suspected or confirmed viral hemorrhagic fever; (3) the implementation of preparedness activities in the context of the recent Ebola crisis; (4) characteristics of admission rooms for patients; and (5) human resources and occupational issues...
January 2017: Health Security
https://www.readbyqxmd.com/read/28153057/unusual-presentation-of-a-severely-ill-patient-having-severe-fever-with-thrombocytopenia-syndrome-a-case-report
#8
Masahiko Kaneko, Masaki Maruta, Hisaharu Shikata, Kengo Asou, Hiroto Shinomiya, Tadaki Suzuki, Hideki Hasegawa, Masayuki Shimojima, Masayuki Saijo
BACKGROUND: Severe fever with thrombocytopenia syndrome is an emerging infectious disease caused by a novel phlebovirus belonging to the family Bunyaviridate. Emergence of encephalitis/encephalopathy during severe fever with thrombocytopenia syndrome progression has been identified as a major risk factor associated with a poor prognosis. Here we report the case of a severely ill patient with severe fever with thrombocytopenia syndrome virus-associated encephalitis/encephalopathy characterized by a lesion of the splenium, which resolved later...
February 3, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28152487/a-heparin-functionalized-carbon-nanotube-based-affinity-biosensor-for-dengue-virus
#9
Daniel Wasik, Ashok Mulchandani, Marylynn V Yates
Dengue virus is an arthropod-borne virus transmitted primarily by Aedes mosquitos and is major cause of disease in tropical and subtropical regions. Colloquially known as Dengue Fever, infection can cause hemorrhagic disorders and death in humans and non-human primates. We report a novel electronic biosensor based on a single-walled carbon nanotube network chemiresistive transducer that is functionalized with heparin for low-cost, label-free, ultra-sensitive, and rapid detection of whole dengue virus (DENV)...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28152326/safety-and-immunogenicity-of-gamevac-combi-a-heterologous-vsv-and-ad5-vectored-ebola-vaccine-an-open-phase-i-ii-trial-in-healthy-adults-in-russia
#10
I V Dolzhikova, O V Zubkova, A I Tukhvatulin, A S Dzharullaeva, N M Tukhvatulina, D V Shcheblyakov, M M Shmarov, E A Tokarskaya, Y V Simakova, D A Egorova, D N Scherbinin, I L Tutykhina, A A Lysenko, A V Kostarnoy, P G Gancheva, T A Ozharovskaya, B V Belugin, L V Kolobukhina, V B Pantyukhov, S I Syromyatnikova, I V Shatokhina, T V Sizikova, I G Rumyantseva, A F Andrus, N V Boyarskaya, A N Voytyuk, V F Babira, S V Volchikhina, D A Kutaev, A N Bel'skih, K V Zhdanov, S M Zakharenko, S V Borisevich, D Y Logunov, B S Naroditsky, A L Gintsburg
Ebola hemorrhagic fever, also known as Ebola virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed the safety, side effects, and immunogenicity of a novel, heterologous prime-boost vaccine against Ebola, which was administered in 2 doses to 84 healthy adults of both sexes between 18 and 55 years. The vaccine consists of live-attenuated recombinant vesicular stomatitis virus (VSV) and adenovirus serotype-5 (Ad5) expressing Ebola envelope glycoprotein...
February 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28137229/challenges-with-mosquito-borne-viral-diseases-outbreak-of-the-monsters
#11
Renu Gautam, Sweta Mishra, Archana Milhotra, Ritika Nagpal, Mradul Mohan, Anchal Singhal, Pratibha Kumari
The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses, all three are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day...
January 30, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28122983/innate-immune-response-of-bat-and-human-cells-to-filoviruses-commonalities-and-distinctions
#12
Ivan V Kuzmin, Toni M Schwarz, Philipp A Ilinykh, Ingo Jordan, Thomas G Ksiazek, Ravi Sachidanandam, Christopher F Basler, Alexander Bukreyev
: Marburg (MARV) and Ebola (EBOV) viruses are zoonotic pathogens that cause severe hemorrhagic fever in humans. The natural reservoir of MARV is the Egyptian rousette bat (Rousettus aegyptiacus); that of EBOV is unknown but believed to be another bat species. The Egyptian rousette develops subclinical productive infection with MARV but is refractory to EBOV. Interaction of filoviruses with hosts is greatly affected by the viral interferon (IFN)-inhibiting domains (IID). Our study was aimed at characterization of innate immune responses to filoviruses and the role of filovirus IID in bat and human cells...
January 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28122569/appearance-of-renal-hemorrhage-in-adult-mice-after-inoculation-of-patient-derived-hantavirus
#13
Kenta Shimizu, Takaaki Koma, Kumiko Yoshimatsu, Yoshimi Tsuda, Yuji Isegawa, Jiro Arikawa
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus infection is characterized by fever, renal dysfunction and hemorrhage. An animal model mimicking symptoms of HFRS remains to be established. In this study, we evaluated the pathogenicity of an HFRS patient-derived Hantaan virus (HTNV) in adult mice. METHODS: Five clones of HTNV strain KHF 83-61 BL (KHFV) that was derived from blood of an HFRS patient were obtained by plaque cloning. The pathogenicity of the virus clones was evaluated by using 6-week-old female BALB/c mice...
January 26, 2017: Virology Journal
https://www.readbyqxmd.com/read/28093544/annual-incidence-of-lassa-virus-infection-in-southern-mali
#14
David Safronetz, Nafomon Sogoba, Sory Ibrahim Diawara, Sidy Bane, Kyle Rosenke, Ousmane Maiga, Matt Boisen, Robert F Garry, Luis M Branco, L Robbin Lindsay, Sékou F Traoré, Heinz Feldmann, Seydou Doumbia
Previously, we reported a high seroprevalence rate of Lassa virus antibodies in inhabitants of three villages in southern Mali where infected rodents have been demonstrated. Herein, we report a 1-year follow-up study in which we were able to collect a second blood samples from 88.7% of participants of the same cohort. We identified 23 seroconversions for IgG antibodies reactive against Lassa virus, representing an incidence of 6.3% (95% confidence interval = 3.8-8.8%). Seroconversion was frequently seen in preteenage children (12/23, 51...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28069471/an-unexpected-fatal-cchf-case-and-management-of-exposed-health-care-workers
#15
Goksel Guven, Leyla Talan, Neriman Defne Altintas, Kemal Osman Memikoglu, Fugen Yoruk, Alpay Azap
Crimean-Congo hemorrhagic fever (CCHF) is a tick borne viral disease which can also be transmitted by direct contact with blood or tissue specimens of infected animals or humans. We present a fatal case of CCHF, who was diagnosed after death, and describe the post-exposure management plan for the health care workers (HCWs) involved in her care. In total of 52 HCWs were involved in the patient's care and they were stratified into risk groups. Overall, 20 HCWs were grouped in high and intermediate risk groups, including the HCW with needle stick injury...
January 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28051834/interferon-%C3%AE-induced-protein-10-in-dengue-virus-infection
#16
P Fallahi, G Elia
Dengue virus (DENV) infection causes dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Interferons (IFNs), and IFN-γ dependent chemokines, chemokine (C-X-C motif) ligand (CXCL)10/IFN-γ-induced protein 10 (IP-10), CXCL9/MIG and CXCL11/I-TAC, and their common receptor chemokine (C-X-C motif) receptor (CXCR)3 are induced by DENV infection; however it has been shown that the latter two could not compensate for the absence of IP-10. This paper reviews studies about DENV and IP-10. Evidences show the importance of IP-10 induction during DENV infection, in macrophages, lymphocytes, hepatic cells, denritic cells, in skin and in the brain...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28031723/economic-report-on-the-cost-of-dengue-fever-in-vietnam-case-of-a-provincial-hospital
#17
Luyen Dinh Pham, Nhat Huy Tran Phung, Nguyen Tu Dang Le, Trung Quang Vo
BACKGROUND: Dengue is a mosquito-borne viral illness with the world's fastest rate of infection. In 2014, Vietnam had recorded 43,000 cases in 53 provinces, with 28 deaths. MATERIALS AND METHODS: A 6-month cross-sectional study was conducted from September 2015 to March 2016 at Cu Chi General Hospital. Cost of illness in this study was estimated under the incidence-based approach from the societal perspective. RESULTS: The average cost per case was US$139...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28031369/mapping-the-human-memory-b-cell-and-serum-neutralizing-antibody-responses-to-dengue-virus-serotype-4-infection-and-vaccination
#18
Usha K Nivarthi, Nurgun Kose, Gopal Sapparapu, Douglas Widman, Emily Gallichotte, Jennifer M Pfaff, Benjamin J Doranz, Daniela Weiskopf, Alessandro Sette, Anna P Durbin, Steve S Whitehead, Ralph Baric, James E Crowe, Aravinda M de Silva
The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses responsible for dengue fever and dengue hemorrhagic fever. People exposed to DENV develop antibodies (Abs) that strongly neutralize the serotype responsible for infection. Historically, infection with DENV serotype 4 (DENV4) has been less common and less studied than infections with the other three serotypes. However, DENV4 has been responsible for recent large and sustained epidemics in Asia and Latin America. The neutralizing antibody responses and the epitopes targeted against DENV4 have not been characterized in human infection...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28000060/a-new-strategy-for-full-length-ebola-virus-glycoprotein-expression-in-e-coli
#19
Junjie Zai, Yinhua Yi, Han Xia, Bo Zhang, Zhiming Yuan
Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression of full-length GP in Escherichia coli hinders the further study of its function in viral pathogenesis. In this study, the vp40 gene was fused to the full-length gp gene and cloned into a prokaryotic expression vector...
December 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27999160/25-hydroxycholesterol-inhibition-of-lassa-virus-infection-through-aberrant-gp1-glycosylation
#20
Punya Shrivastava-Ranjan, Éric Bergeron, Ayan K Chakrabarti, César G Albariño, Mike Flint, Stuart T Nichol, Christina F Spiropoulou
: Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25-hydroxycholesterol (25HC). 25HC is involved in regulating cholesterol biosynthesis and has recently been identified as a potent antiviral targeting enveloped virus entry. Here, we show a previously unrecognized role of CH25H in inhibiting LASV glycoprotein glycosylation and the production of infectious virus...
December 20, 2016: MBio
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