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https://www.readbyqxmd.com/read/28726401/amidoalkylindoles-as-potent-and-selective-cannabinoid-type-2-receptor-agonists-with-in-vivo-efficacy-in-a-mouse-model-of-multiple-sclerosis
#1
Ying Shi, Yan-Hui Duan, Yue-Yang Ji, Zhi-Long Wang, Yan-Ran Wu, Hendra Gunosewoyo, Xiao-Yu Xie, Jian-Zhong Chen, Fan Yang, Jing Li, Jie Tang, Xin Xie, Li-Fang Yu
Selective CB2 agonists represent an attractive therapeutic strategy for the treatment of a variety of diseases without psychiatric side effects mediated by the CB1 receptor. We carried out a rational optimization of a black market designer drug SDB-001 that led to the identification of potent and selective CB2 agonists. A 7-methoxy or 7-methylthio substitution at the 3-amidoalkylindoles resulted in potent CB2 antagonists (27 or 28, IC50 = 16-28 nM). Replacement of the amidoalkyls from 3-position to the 2-position of the indole ring dramatically increased the agonist selectivity on the CB2 over CB1 receptor...
July 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28682615/phytochemical-studies-on-two-australian-anigozanthos-plant-species
#2
Rudi Hendra, Paul A Keller
Phytochemical studies of two Australian Anigozanthos (kangaroo paw) species, A. rufus and A. pulcherrimus, resulted in the identification of 13 secondary metabolites. 2-Amino-6-O-p-coumarylheptanedioic acid (3) and chalcone-5'-O-(4-O-p-coumaryl)-O-β-d-glucopyranoside (12) are reported as new compounds and are accompanied by nine flavonoids (2, 5-11, 13) and two anthocyanins (1, 4). Compounds 1 and 4 were isolated as red solids from A. rufus and are likely responsible for the coloration of the flowers. Compounds 1, 3, and 6 showed weak antimicrobial activities against Acinetobacter baumannii ATCC 19606 at concentrations of 52...
July 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28681249/a-systematic-review-of-the-barriers-affecting-medication-adherence-in-patients-with-rheumatic-diseases
#3
REVIEW
Hendra Goh, Yu Heng Kwan, Yi Seah, Lian Leng Low, Warren Fong, Julian Thumboo
Medication adherence is a crucial part in the management of rheumatic diseases, especially with many such patients requiring long-term medications. In this paper, we aim to systematically review the literature for the factors associated with medication adherence in the rheumatic patient population. We carried out a systematic literature search using PubMed(®), PsychInfo(®) and Embase (®) with relevant keywords and employed the PRISMA(®) criteria. We included English peer-reviewed articles that studied the factors affecting medication adherence in patients with rheumatic diseases, which were assessed by two independent reviewers...
July 5, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28680971/hendra-and-nipah-virus-infection-in-cultured-human-olfactory-epithelial-cells
#4
Viktoriya Borisevich, Mehmet Hakan Ozdener, Bilal Malik, Barry Rockx
Henipaviruses are emerging zoonotic viruses and causative agents of encephalitis in humans. However, the mechanisms of entry into the central nervous system (CNS) in humans are not known. Here, we evaluated the possible role of olfactory epithelium in virus entry into the CNS. We characterized Hendra virus (HeV) and Nipah virus (NiV) infection of primary human olfactory epithelial cultures. We show that henipaviruses can infect mature olfactory sensory neurons. Henipaviruses replicated efficiently, resulting in cytopathic effect and limited induction of host responses...
May 2017: MSphere
https://www.readbyqxmd.com/read/28674944/a-functional-genomics-approach-to-henipavirus-research-the-role-of-nuclear-proteins-micrornas-and-immune-regulators-in-infection-and-disease
#5
Cameron R Stewart, Celine Deffrasnes, Chwan Hong Foo, Andrew G D Bean, Lin-Fa Wang
Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are zoonotic RNA viruses that cause lethal disease in humans and are designated as Biosafety Level 4 (BSL4) agents. Moreover, henipaviruses belong to the same group of viruses that cause disease more commonly in humans such as measles, mumps and respiratory syncytial virus. Due to the relatively recent emergence of the henipaviruses and the practical constraints of performing functional genomics studies at high levels of containment, our understanding of the henipavirus infection cycle is incomplete...
July 4, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28672195/combination-treatment-with-the-gsk-3-inhibitor-9-ing-41-and-ccnu-cures-orthotopic-chemoresistant-glioblastoma-in-patient-derived-xenograft-models
#6
Andrey Ugolkov, Wenan Qiang, Gennadiy Bondarenko, Daniel Procissi, Irina Gaisina, C David James, James Chandler, Alan Kozikowski, Hendra Gunosewoyo, Thomas O'Halloran, Jeffrey Raizer, Andrew P Mazar
Resistance to chemotherapy remains a major challenge in the treatment of human glioblastoma (GBM). Glycogen synthase kinase-3β (GSK-3β), a positive regulator of NF-κB-mediated survival and chemoresistance of cancer cells, has been identified as a potential therapeutic target in human GBM. Our objective was to determine the antitumor effect of GSK-3 inhibitor 9-ING-41 in combination with chemotherapy in patient-derived xenograft (PDX) models of human GBM. We utilized chemoresistant PDX models of GBM, GBM6 and GBM12, to study the effect of 9-ING-41 used alone and in combination with chemotherapy on tumor progression and survival...
June 30, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28636633/playing-with-fire-what-is-influencing-horse-owners-decisions-to-not-vaccinate-their-horses-against-deadly-hendra-virus-infection
#7
Kailiea Arianna Goyen, John David Wright, Alexandra Cunneen, Joerg Henning
Hendra virus is a zoonotic paramyxovirus, which causes severe respiratory and neurological disease in horses and humans. Since 2012, the Hendra virus sub-unit G vaccine has been available for horse vaccination in Australia. Uptake of the vaccine has been limited and spill-over events of Hendra virus infection in horses continue to occur. We conducted an online, questionnaire-based cross-sectional study of 376 horse owners belonging to a variety of different equestrian clubs in Queensland, Australia, to identify risk factors for non-vaccination against Hendra virus...
2017: PloS One
https://www.readbyqxmd.com/read/28629988/4-azidocytidine-r1479-inhibits-henipaviruses-and-other-paramyxoviruses-with-high-potency
#8
Anne L Hotard, Biao He, Stuart T Nichol, Christina F Spiropoulou, Michael K Lo
The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of developing small-molecule nucleoside inhibitors against henipaviruses, we evaluated the antiviral activity of 4'-azidocytidine (R1479), a drug previously identified to inhibit flaviviruses, against henipaviruses along with other representative members of the family Paramyxoviridae...
June 17, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28616484/climatic-suitability-influences-species-specific-abundance-patterns-of-australian-flying-foxes-and-risk-of-hendra-virus-spillover
#9
Gerardo A Martin, Carlos Yanez-Arenas, Billie J Roberts, Carla Chen, Raina K Plowright, Rebecca J Webb, Lee F Skerratt
Hendra virus is a paramyxovirus of Australian flying fox bats. It was first detected in August 1994, after the death of 20 horses and one human. Since then it has occurred regularly within a portion of the geographical distribution of all Australian flying fox (fruit bat) species. There is, however, little understanding about which species are most likely responsible for spillover, or why spillover does not occur in other areas occupied by reservoir and spillover hosts. Using ecological niche models of the four flying fox species we were able to identify which species are most likely linked to spillover events using the concept of distance to the niche centroid of each species...
December 2016: One Health
https://www.readbyqxmd.com/read/28601688/structure-and-organization-of-paramyxovirus-particles
#10
REVIEW
Robert M Cox, Richard K Plemper
The paramyxovirus family comprises major human and animal pathogens such as measles virus (MeV), mumps virus (MuV), the parainfluenzaviruses, Newcastle disease virus (NDV), and the highly pathogenic zoonotic hendra (HeV) and nipah (NiV) viruses. Paramyxovirus particles are pleomorphic, with a lipid envelope, nonsegmented RNA genomes of negative polarity, and densely packed glycoproteins on the virion surface. A number of crystal structures of different paramyxovirus proteins and protein fragments were solved, but the available information concerning overall virion organization remains limited...
June 8, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28600653/how-order-and-disorder-within-paramyxoviral-nucleoproteins-and-phosphoproteins-orchestrate-the-molecular-interplay-of-transcription-and-replication
#11
REVIEW
Sonia Longhi, Louis-Marie Bloyet, Stefano Gianni, Denis Gerlier
In this review, we summarize computational and experimental data gathered so far showing that structural disorder is abundant within paramyxoviral nucleoproteins (N) and phosphoproteins (P). In particular, we focus on measles, Nipah, and Hendra viruses and highlight both commonalities and differences with respect to the closely related Sendai virus. The molecular mechanisms that control the disorder-to-order transition undergone by the intrinsically disordered C-terminal domain (NTAIL) of their N proteins upon binding to the C-terminal X domain (XD) of the homologous P proteins are described in detail...
June 9, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28559814/the-rare-case-of-pemphigus-vegetans-in-association-with-malnutrition-children-in-the-multidisciplinary-management
#12
Oki Suwarsa, Endang Sutedja, Hartati Purbo Dharmadji, Pramita Kusuma, July Rahardja, Reti Hindritiani, Hendra Gunawan
Pemphigus vegetans is a clinical variant of pemphigus vulgaris, accounting for 1-2% of all very rare pemphigus cases in children. The involvement of the oral mucosa in this disease is usually accompanied by severe pain that aggravates the patient's malnourished condition. Conversely, malnutrition may also reduce vulnerability towards autoimmune diseases. Although pemphigus vegetans has never been reported to develop in a child with marasmus before, we encountered a case of pemphigus vegetans in a severely malnourished patient...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28553176/metabolic-activity-value-in-the-posterior-cingulate-cortex-using-f-18-fluorodeoxyglucose-positron-emission-tomography-brain-to-predict-the-severity-of-alzheimer-s
#13
Aulia Huda, Achmad Hussein Sundawa Kartamihardja, Budi Darmawan, Hendra Budiawan, Martina Wiwie
Alzheimer's disease (AD) is a type of dementia which is known as one of a major problem in elderly. Clinicians commonly use mini-mental state examination (MMSE) score to determine the severity of cognitive decline, but MMSE has some limitations such as more subjective, influenced by age, educational degree, and local culture. F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) can be used to assess the process of glucose metabolism in posterior cingulate cortex (PCC) area which endures a central role in supporting cognitive function directly...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28468881/mutations-in-the-transmembrane-domain-and-cytoplasmic-tail-of-hendra-virus-fusion-protein-disrupt-virus-like-particle-assembly
#14
Nicolás Cifuentes-Muñoz, Weina Sun, Greeshma Ray, Phuong Tieu Schmitt, Stacy Webb, Kathleen Gibson, Rebecca Ellis Dutch, Anthony P Schmitt
Hendra virus (HeV) is a zoonotic paramyxovirus that causes deadly illness in horses and humans. An intriguing feature of HeV is the utilization of endosomal protease for activation of the viral fusion protein (F). Here we investigated how endosomal F trafficking affects HeV assembly. We found that the HeV matrix (M) and F proteins each induced particle release when they were expressed alone but that their coexpression led to coordinated assembly of virus-like particles (VLPs) that were morphologically and physically distinct from M-only or F-only VLPs...
July 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28460752/-we-ve-learned-to-live-with-it-a-qualitative-study-of-australian-horse-owners-attitudes-perceptions-and-practices-in-response-to-hendra-virus
#15
Anke K Wiethoelter, Kate Sawford, Nicole Schembri, Melanie R Taylor, Navneet K Dhand, Barbara Moloney, Therese Wright, Nina Kung, Hume E Field, Jenny-Ann L M L Toribio
Hendra virus causes sporadic zoonotic disease in Australia following spill over from flying foxes to horses and from horses to people. Prevention and risk mitigation strategies such as vaccination of horses or biosecurity and property management measures are widely publicised, but hinge on initiative and action taken by horse owners as they mediate management, care and treatment of their animals. Hence, underlying beliefs, values and attitudes of horse owners influence their uptake of recommended risk mitigation measures...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28446155/erratum-to-higher-serum-betatrophin-level-in-type-2-diabetes-subjects-is-associated-with-urinary-albumin-excretion-and-renal-function
#16
Chang-Chiang Chen, Hendra Susanto, Wen-Han Chuang, Ta-Yu Liu, Arivajiagane Arundhathi, Chih-Hong Wang
No abstract text is available yet for this article.
April 26, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28433050/zoonotic-potential-of-emerging-paramyxoviruses-knowns-and-unknowns
#17
Patricia A Thibault, Ruth E Watkinson, Andres Moreira-Soto, Jan F Drexler, Benhur Lee
The risk of spillover of enzootic paramyxoviruses and the susceptibility of recipient human and domestic animal populations are defined by a broad collection of ecological and molecular factors that interact in ways that are not yet fully understood. Nipah and Hendra viruses were the first highly lethal zoonotic paramyxoviruses discovered in modern times, but other paramyxoviruses from multiple genera are present in bats and other reservoirs that have unknown potential to spillover into humans. We outline our current understanding of paramyxovirus reservoir hosts and the ecological factors that may drive spillover, and we explore the molecular barriers to spillover that emergent paramyxoviruses may encounter...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28407738/-why-won-t-they-just-vaccinate-horse-owner-risk-perception-and-uptake-of-the-hendra-virus-vaccine
#18
J Manyweathers, H Field, N Longnecker, K Agho, C Smith, M Taylor
BACKGROUND: Hendra virus is a paramyxovirus that causes periodic serious disease and fatalities in horses and humans in Australia first identified in 1994. Pteropid bats (commonly known as flying-foxes) are the natural host of the virus, and the putative route of infection in horses is by ingestion or inhalation of material contaminated by flying-fox urine or other bodily fluids. Humans become infected after close contact with infected horses. Horse owners in Australia are encouraged to vaccinate their horses against Hendra virus to reduce the risk of Hendra virus infection, and to prevent potential transmission to humans...
April 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28381569/group-a-rotaviruses-in-chinese-bats-genetic-composition-serology-and-evidence-for-bat-to-human-transmission-and-reassortment
#19
Biao He, Xiaohong Huang, Fuqiang Zhang, Weilong Tan, Jelle Matthijnssens, Shaomin Qin, Lin Xu, Zihan Zhao, Ling'en Yang, Quanxi Wang, Tingsong Hu, Xiaolei Bao, Jianmin Wu, Changchun Tu
Bats are natural reservoirs for many pathogenic viruses, and increasing evidence supports the notion that bats can also harbor group A rotaviruses (RVAs), important causative agents of diarrhea in children and young animals. Currently, 8 RVA strains possessing completely novel genotype constellations or genotypes possibly originating from other mammals have been identified from African and Chinese bats. However, all the data were mainly based on detection of RVA RNA, present only during acute infections, which does not permit assessment of the true exposure of a bat population to RVA...
June 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28214468/difficulties-experienced-by-veterinarians-when-communicating-about-emerging-zoonotic-risks-with-animal-owners-the-case-of-hendra-virus
#20
Diana H Mendez, Petra Büttner, Jenny Kelly, Madeleine Nowak, Rick Speare Posthumously
BACKGROUND: Communication skills are essential for veterinarians who need to discuss animal health related matters with their clients. When dealing with an emerging zoonosis, such as Hendra virus (HeV), veterinarians also have a legal responsibility to inform their clients about the associated risks to human health. Here we report on part of a mixed methods study that examined the preparedness of, and difficulties experienced by, veterinarians communicating about HeV-related risks with their clients...
February 18, 2017: BMC Veterinary Research
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