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https://www.readbyqxmd.com/read/29765101/favipiravir-t-705-protects-against-nipah-virus-infection-in-the-hamster-model
#1
Brian E Dawes, Birte Kalveram, Tetsuro Ikegami, Terry Juelich, Jennifer K Smith, Lihong Zhang, Arnold Park, Benhur Lee, Takashi Komeno, Yousuke Furuta, Alexander N Freiberg
Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates ranging from 40-75%. Despite the severe pathogenicity of these viruses and their pandemic potential, no therapeutics or vaccines are currently approved for use in humans. Favipiravir (T-705) is a purine analogue antiviral approved for use in Japan against emerging influenza strains; and several phase 2 and 3 clinical trials are ongoing in the United States and Europe...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29708971/indirect-elisa-based-on-hendra-and-nipah-virus-proteins-for-the-detection-of-henipavirus-specific-antibodies-in-pigs
#2
Kerstin Fischer, Sandra Diederich, Greg Smith, Sven Reiche, Vinicius Pinho Dos Reis, Eileen Stroh, Martin H Groschup, Hana M Weingartl, Anne Balkema-Buschmann
Hendra virus (HeV) and Nipah virus (NiV) belong to the genus Henipavirus in the family Paramyxoviridae. Henipavirus infections were first reported in the 1990's causing severe and often fatal outbreaks in domestic animals and humans in Southeast Asia and Australia. NiV infections were observed in humans in Bangladesh, India and in the first outbreak in Malaysia, where pigs were also infected. HeV infections occurred in horses in the North-Eastern regions of Australia, with singular transmission events to humans...
2018: PloS One
https://www.readbyqxmd.com/read/29695428/electrostatic-interactions-between-hendra-virus-matrix-proteins-are-required-for-efficient-virus-like-particle-assembly
#3
Yu Chih Liu, Julian Grusovin, Timothy E Adams
Hendra virus (HeV) is a zoonotic paramyxovirus belonging to the genus Henipavirus. HeV is highly pathogenic, and it can cause severe neurological and respiratory illnesses in both humans and animals, with an extremely high mortality rate of up to 70%. Amongst the genes that HeV encodes, the matrix (M) protein forms an integral part of the virion structure and plays critical roles in coordinating viral assembly and budding. Nevertheless, the molecular mechanism of this process is not fully elucidated. Here, we determined the crystal structure of HeV M to 2...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29691855/virus-neutralising-antibody-responses-in-horses-following-vaccination-with-equivac%C3%A2-hev-a-field-study
#4
Rhh Tan, A Hodge, R Klein, N Edwards, J A Huang, D Middleton, S P Watts
OBJECTIVE: To determine the antibody responses to a commercial Hendra virus vaccine (Equivac® HeV) in a field environment. METHODS: A group of 61 horses received a primary vaccination course comprising two doses administered 3-6 weeks apart (V1, V2) and a 3rd dose (V3) given 6 months after the second. This was followed by booster vaccinations at 12 monthly intervals (V4, V5). Antibody titres were assessed using a virus-neutralisation test. RESULTS: Neutralising antibodies against HeV were not detected prior to vaccination...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691656/exploration-of-nucleoprotein-%C3%AE-more-and-xd-interactions-of-nipah-and-hendra-viruses
#5
Xu Shang, Wenting Chu, Xiakun Chu, Liufang Xu, Sonia Longhi, Jin Wang
Henipavirus, including Hendra virus (HeV) and Nipah virus (NiV), is a newly discovered human pathogen genus. The nucleoprotein of Henipavirus contains an α-helical molecular recognition element (α-MoRE) that folds upon binding to the X domain (XD) of the phosphoprotein (P). In order to explore the conformational dynamics of free α-MoREs and the underlying binding-folding mechanism with XD, atomic force field-based and hybrid structure-based MD simulations were carried out. In our empirical force field-based simulations, characteristic structures and helicities of α-MoREs reveal the co-existence of partially structured and disordered conformations, as in the case of the well characterized cognate measles virus (MeV) α-MoRE...
April 24, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29685227/formation-of-high-order-oligomers-is-required-for-functional-bioactivity-of-an-african-bat-henipavirus-surface-glycoprotein
#6
Laura Behner, Louisa Zimmermann, Marc Ringel, Michael Weis, Andrea Maisner
Hendra virus (HeV) and Nipah virus (NiV) are highly pathogenic henipaviruses originating from fruit bats in Australia and Asia that can cause severe infections in livestock and humans. In recent years, also African bat henipaviruses were identified at the nucleic acid level. To assess their potential to replicate in non-bat species, several studies were performed to characterize the two surface glycoproteins required for virus entry and spread by cell-cell fusion. It has been shown that surface expression and fusion-helper function of the receptor-binding G protein of Kumasi virus (KV), the prototypic Ghanaian bat henipavirus, is reduced compared to other non-African henipavirus G proteins...
May 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29643201/nipah-virus-infection
#7
Brenda S P Ang, Tchoyoson C C Lim, Linfa Wang
Nipah virus, a Paramyxovirus related to Hendra first emerged in Malaysia in 1998. Clinical presentation ranges from asymptomatic infection to fatal encephalitis. Malaysia has had no more cases since 1999, but outbreaks continue to occur in Bangladesh and India. In the Malaysia-Singapore outbreak, transmission occurred primarily through contact with pigs while in Bangladesh-India, it is associated with ingestion of contaminated date palm sap and human-to-human transmission. Bats are the main reservoir for this virus which can cause disease in humans and animals...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29609927/complementary-and-alternative-medicine-for-rheumatic-diseases-a-systematic-review-of-randomized-controlled-trials
#8
REVIEW
Jie Kie Phang, Yu Heng Kwan, Hendra Goh, Victoria Ie Ching Tan, Julian Thumboo, Truls Østbye, Warren Fong
OBJECTIVES: To summarize all good quality randomized controlled trials (RCTs) using complementary and alternative medicine (CAM) interventions in patients with rheumatic diseases. METHODS: A systematic literature review guided by the Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) was performed. We excluded non-English language articles and abstract-only publications. Due to the large number of RCTs identified, we only include "good quality" RCTs with Jadad score of five...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29601894/susceptibility-of-paramyxoviruses-and-filoviruses-to-inhibition-by-2-monofluoro-and-2-difluoro-4-azidocytidine-analogs
#9
Michael K Lo, Paul C Jordan, Sarah Stevens, Yuen Tam, Jerome Deval, Stuart T Nichol, Christina F Spiropoulou
Ebolaviruses, marburgviruses, and henipaviruses are zoonotic pathogens belonging to the Filoviridae and Paramyxoviridae families. They exemplify viruses that continue to spill over into the human population, causing outbreaks characterized by high mortality and significant clinical sequelae in survivors of infection. There are currently no approved small molecule therapeutics for use in humans against these viruses. In this study, we evaluated the antiviral activity of the nucleoside analog 4'-azidocytidine (4'N3 -C, R1479) and its 2'-monofluoro- and 2'-difluoro-modified analogs (2'F-4'N3 -C and 2'diF-4'N3 -C) against representative paramyxoviruses (Nipah virus, Hendra virus, measles virus, and human parainfluenza virus 3) and filoviruses (Ebola virus, Sudan virus, and Ravn virus)...
March 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29587789/rescue-and-characterization-of-recombinant-cedar-virus-a-non-pathogenic-henipavirus-species
#10
Eric D Laing, Moushimi Amaya, Chanakha K Navaratnarajah, Yan-Ru Feng, Roberto Cattaneo, Lin-Fa Wang, Christopher C Broder
BACKGROUND: Hendra virus and Nipah virus are zoonotic viruses that have caused severe to fatal disease in livestock and human populations. The isolation of Cedar virus, a non-pathogenic virus species in the genus Henipavirus, closely-related to the highly pathogenic Hendra virus and Nipah virus offers an opportunity to investigate differences in pathogenesis and receptor tropism among these viruses. METHODS: We constructed full-length cDNA clones of Cedar virus from synthetic oligonucleotides and rescued two replication-competent, recombinant Cedar virus variants: a recombinant wild-type Cedar virus and a recombinant Cedar virus that expresses a green fluorescent protein from an open reading frame inserted between the phosphoprotein and matrix genes...
March 27, 2018: Virology Journal
https://www.readbyqxmd.com/read/29577250/in-this-issue-april-2018-dairy-calf-management-in-victoria-%C3%A2-ai-with-ovulation-re-synchrony-%C3%A2-medical-events-after-greyhound-racing-%C3%A2-poultry-behaviour-in-different-environments-%C3%A2-hendra-virus-vaccine-does-not-affect-racing-performance-%C3%A2-lack-of-consistency
#11
EDITORIAL
https://www.readbyqxmd.com/read/29562867/cortical-neurons-derived-from-equine-induced-pluripotent-stem-cells-are-susceptible-to-neurotropic-flavivirus-infection-and-replication-an-in-vitro-model-for-equine-neuropathic-diseases
#12
Patrick R J Fortuna, Helle Bielefeldt-Ohmann, Dmitry A Ovchinnikov, Ernst Jurgen Wolvetang, Deanne Jeanette Whitworth
Horses are susceptible to a number of neurotropic viruses, including West Nile virus (WNV), which is a pathogen of global significance in both horses and humans. However, there are no in vitro models with which to study infectious neuropathic diseases in the horse. In an effort to redress this we have generated neurons from equine induced pluripotent stem cells (equiPSCs) that express a range of cortical neuron-specific markers, in addition to the membrane-bound ligand Ephrin B3, which plays an important role in axon guidance as well as functioning as the receptor through which henipaviruses, such as Hendra virus, enter mammalian neurons...
March 21, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29556762/climate-change-could-increase-the-geographic-extent-of-hendra-virus-spillover-risk
#13
Gerardo Martin, Carlos Yanez-Arenas, Carla Chen, Raina K Plowright, Rebecca J Webb, Lee F Skerratt
Disease risk mapping is important for predicting and mitigating impacts of bat-borne viruses, including Hendra virus (Paramyxoviridae:Henipavirus), that can spillover to domestic animals and thence to humans. We produced two models to estimate areas at potential risk of HeV spillover explained by the climatic suitability for its flying fox reservoir hosts, Pteropus alecto and P. conspicillatus. We included additional climatic variables that might affect spillover risk through other biological processes (such as bat or horse behaviour, plant phenology and bat foraging habitat)...
March 19, 2018: EcoHealth
https://www.readbyqxmd.com/read/29538374/host-gene-expression-profiles-in-ferrets-infected-with-genetically-distinct-henipavirus-strains
#14
Alberto J Leon, Viktoriya Borisevich, Nahal Boroumand, Robert Seymour, Rebecca Nusbaum, Olivier Escaffre, Luoling Xu, David J Kelvin, Barry Rockx
Henipavirus infection causes severe respiratory and neurological disease in humans that can be fatal. To characterize the pathogenic mechanisms of henipavirus infection in vivo, we performed experimental infections in ferrets followed by genome-wide gene expression analysis of lung and brain tissues. The Hendra, Nipah-Bangladesh, and Nipah-Malaysia strains caused severe respiratory and neurological disease with animals succumbing around 7 days post infection. Despite the presence of abundant viral shedding, animal-to-animal transmission did not occur...
March 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29537479/strengthening-primary-care-through-family-medicine-around-the-world-collaborating-toward-promising-practices
#15
Katherine Rouleau, Monique Bourget, Patrick Chege, Francois Couturier, Paula Godoy-Ruiz, Paul H Grand'Maison, Melanie Henry, Kerling Israel, Videsh Kapoor, Hendra Kurniawan, Louella Lobo, Mahamane Maiga, Samantha Pereira Franca, Lynda Redwood-Campbell, Jamie Rodas, Raman Sohal, Dawit Wondimagegn, Robert Woolard
BACKGROUND AND OBJECTIVES: There is a limited evidentiary base on the development of family medicine in different contexts and countries. The lack of evidence impedes our ability to compare and characterize family medicine models and identify areas of success that have led to the effective provision of care. This paper offers a comparative compilation and analysis of the development of family medicine training programs in seven countries: Brazil, Canada, Ethiopia, Haiti, Indonesia, Kenya, and Mali...
March 8, 2018: Family Medicine
https://www.readbyqxmd.com/read/29522528/development-of-a-reverse-genetics-system-for-sosuga-virus-allows-rapid-screening-of-antiviral-compounds
#16
Stephen R Welch, Ayan K Chakrabarti, Lisa Wiggleton Guerrero, Harley M Jenks, Michael K Lo, Stuart T Nichol, Christina F Spiropoulou, César G Albariño
Sosuga virus (SOSV) is a recently discovered zoonotic paramyxovirus isolated from a single human case in 2012; it has been ecologically and epidemiologically associated with transmission by the Egyptian rousette bat (Rousettus aegyptiacus). Bats have long been recognized as sources of novel zoonotic pathogens, including highly lethal paramyxoviruses like Nipah virus (NiV) and Hendra virus (HeV). The ability of SOSV to cause severe human disease supports the need for studies on SOSV pathogenesis to better understand the potential impact of this virus and to identify effective treatments...
March 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29516895/reactive-perforating-leprosy-erythema-multiforme-like-reactions-sweet-s-syndrome-like-reactions-as-atypical-clinical-manifestations-of-type-2-leprosy-reaction
#17
Hendra Gunawan, Yuri Yogya, Risty Hafinah, Rachel Marsella, Devi Ermawaty, Oki Suwarsa
Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29463198/a-network-approach-for-provisional-assay-recognition-of-a-hendra-virus-antibody-elisa-test-validation-with-low-sample-numbers-from-infected-horses
#18
Axel Colling, Ross Lunt, Jemma Bergfeld, Leanne McNabb, Kim Halpin, Susan Juzva, Kim Newberry, Chris Morrissy, Cameron Loomes, Simone Warner, Ibrahim Diallo, Peter Kirkland, Christopher C Broder, Gemma Carlile, Mai Hlaing Loh, Caryll Waugh, Lynda Wright, James Watson, Debbie Eagles, Kurt Zuelke, Sam McCullough, Peter Daniels
Obtaining statistically sound numbers of sera from Hendra virus (HeV)-infected horses is problematic because affected individuals usually die or are euthanized before developing a serum antibody response. As a consequence, test validation becomes a challenge. Our approach is an extension of OIE principles for provisional recognition and included 7 validation panels tested across multiple laboratories that provided estimates for test performance characteristics. At a 0.4 S/P cutoff, 16 of 19 sera from HeV-infected horses gave positive results in the HeV soluble G, indirect ELISA (HeVsG iELISA; DSe 84...
May 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29436564/the-effects-of-celery-leaf-apium-graveolens-l-treatment-on-blood-glucose-and-insulin-levels-in-elderly-pre-diabetics
#19
Yusni Yusni, Hendra Zufry, Firdalena Meutia, Krishna W Sucipto
To analyze the effect of celery leaf extract on blood glucose and plasma insulin levels in elderly pre-diabetics. Methods: This study was conducted between March and November 2014 at the Faculty of Medicine, Syiah Kuala University, Banda Aceh, Indonesia. A quasi-experimental pretest-posttest with a control group was conducted with elderly pre-diabetic volunteers. The subjects included 16 elderly pre-diabetics older than 60 (6 males and 10 females). The subjects were randomly divided into 2 groups: a control group (placebo-treated) and a treatment group (celery-treated)...
February 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29399777/investigation-of-the-effect-of-equivac%C3%A2-hev-hendra-virus-vaccination-on-thoroughbred-racing-performance
#20
K Schemann, E J Annand, P A Reid, M F Lenz, P C Thomson, N K Dhand
OBJECTIVE: To evaluate the effect of Equivac® HeV Hendra virus vaccine on Thoroughbred racing performance. DESIGN: Retrospective pre-post intervention study. METHODS: Thoroughbreds with at least one start at one of six major south-eastern Queensland race tracks between 1 July 2012 and 31 December 2016 and with starts in the 3-month periods before and after Hendra virus vaccinations were identified. Piecewise linear mixed models compared the trends in 'Timeform rating' and 'margin to winner' before and after initial Hendra virus vaccination...
April 2018: Australian Veterinary Journal
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