keyword
https://read.qxmd.com/read/38615488/optical-controlled-and-nuclear-targeted-cecr2-competitor-to-downregulate-csf-1-for-metastatic-breast-cancer-immunotherapy
#21
JOURNAL ARTICLE
Yi Cen, Ying Chen, Xinxuan Li, Xiayun Chen, Baixue Yu, Mengyi Yan, Ni Yan, Hong Cheng, Shiying Li
The crosstalk between breast cancer cells and tumor associated macrophages (TAMs) greatly contributes to tumor progression and immunosuppression. In this work, cat eye syndrome chromosome region candidate 2 (CECR2) is identified to overexpress in breast cancer patients, which can recognize v-rel avian reticuloendotheliosis viral oncogene homolog A (RelA) and activate nuclear factor κB (NF-κB) to release colony stimulating factor-1 (CSF-1). Pharmacological inhibition of CECR2 by the bromodomain competitor (Bromosporine, Bro) can downregulate CSF-1 to inhibit M2 type TAMs...
April 12, 2024: Biomaterials
https://read.qxmd.com/read/38614267/potential-therapeutic-targets-in-myeloid-cell-therapy-for-overcoming-chemoresistance-and-immune-suppression-in-gastrointestinal-tumors
#22
REVIEW
Jiawei Fan, Jianshu Zhu, He Zhu, Hong Xu
In the tumor microenvironment (TME), myeloid cells play a pivotal role. Myeloid-derived immunosuppressive cells, including tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), are central components in shaping the immunosuppressive milieu of the tumor. Within the TME, a majority of TAMs assume an M2 phenotype, characterized by their pro-tumoral activity. These cells promote tumor cell growth, angiogenesis, invasion, and migration. In contrast, M1 macrophages, under appropriate activation conditions, exhibit cytotoxic capabilities against cancer cells...
April 11, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38614155/tittle-a-multimodal-tissue-perfusion-measurement-approach-for-the-evaluation-of-the-effect-of-pimobendan-an-inodilator-in-a-porcine-sepsis-model
#23
JOURNAL ARTICLE
Mathieu Magnin, Morgane Gavet, Thien-Tam Ngo, Vanessa Louzier, Tatiana Victoni, Jean Yves Ayoub, Bernard Allaouchiche, Jeanne-Marie Bonnet-Garin, Stéphane Junot
Sepsis is associated with hypoperfusion and organ failure. The aims of the study were: 1) to assess the effect of pimobendan on macrocirculation and perfusion and 2) to describe a multimodal approach to the assessment of perfusion in sepsis and compare the evolution of the perfusion parameters. Eighteen anaesthetized female piglets were equipped for macrocirculation monitoring. Sepsis was induced by an infusion of Pseudomonas aeruginosa. After the occurrence of hypotension, animals were resuscitated. Nine pigs received pimobendan at the start of resuscitation maneuvers, the others received saline...
April 11, 2024: Microvascular Research
https://read.qxmd.com/read/38613910/subtyping-of-triple-negative-breast-cancers-its-prognostication-and-implications-in-diagnosis-of-breast-origin
#24
JOURNAL ARTICLE
H Hu, K Tong, J Y Tsang, C W Ko, F Tam, T C Loong, G M Tse
BACKGROUND: Triple-negative breast cancer (TNBC) subtyping by gene profiling has provided valuable clinical information. Here, we aimed to evaluate the relevance of TNBC subtyping using immunohistochemistry (IHC), which could be a more clinically practical approach, for prognostication and applications in patient management. METHODS: A total of 123 TNBC cases were classified using androgen receptor (AR), CD8, Forkhead box C1 protein (FOXC1), and doublecortin-like kinase 1 (DCLK1) into luminal androgen receptor (LAR), basal-like immunosuppressive (BLIS), mesenchymal-like (MES), and immunomodulatory (IM) subtypes...
April 12, 2024: ESMO Open
https://read.qxmd.com/read/38613566/reaction-of-khp-with-excess-naoh-or-tris-as-standard-reactions-for-calibration-of-titration-calorimeters-from-0-to-60%C3%A2-%C3%A2-c
#25
JOURNAL ARTICLE
Jason D Kenealey, Margarida Bastos, Zaid Assaf, Guangyue Bai, Wenqi Zhao, Tyler Jarrard, Colter Tower, Lee D Hansen
Calibration of titration calorimeters is an ongoing problem, particularly with calorimeters with reaction vessel volumes < 10 mL in which an electrical calibration heater is positioned outside the calorimetric vessel. Consequently, a chemical reaction with a known enthalpy change must be used to accurately calibrate these calorimeters. This work proposes the use of standard solutions of potassium acid phthalate (KHP) titrated into solutions of excess sodium hydroxide (NaOH) or excess tris(hydroxymethyl)aminomethane (TRIS) as standard reactions to determine the collective accuracy of the relevant variables in a determination of the molar enthalpy change for a reaction...
April 13, 2024: European Biophysics Journal: EBJ
https://read.qxmd.com/read/38613283/study-of-high-transverse-momentum-higgs-boson-production-in-association-with-a-vector-boson-in-the-qqbb-final-state-with-the-atlas-detector
#26
JOURNAL ARTICLE
G Aad, B Abbott, K Abeling, N J Abicht, S H Abidi, A Aboulhorma, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, C Adam Bourdarios, L Adamczyk, S V Addepalli, M J Addison, J Adelman, A Adiguzel, T Adye, A A Affolder, Y Afik, M N Agaras, J Agarwala, A Aggarwal, C Agheorghiesei, A Ahmad, F Ahmadov, W S Ahmed, S Ahuja, X Ai, G Aielli, A Aikot, M Ait Tamlihat, B Aitbenchikh, I Aizenberg, M Akbiyik, T P A Åkesson, A V Akimov, D Akiyama, N N Akolkar, S Aktas, K Al Khoury, G L Alberghi, J Albert, P Albicocco, G L Albouy, S Alderweireldt, Z L Alegria, M Aleksa, I N Aleksandrov, C Alexa, T Alexopoulos, F Alfonsi, M Algren, M Alhroob, B Ali, H M J Ali, S Ali, S W Alibocus, M Aliev, G Alimonti, W Alkakhi, C Allaire, B M M Allbrooke, J F Allen, C A Allendes Flores, P P Allport, A Aloisio, F Alonso, C Alpigiani, M Alvarez Estevez, A Alvarez Fernandez, M Alves Cardoso, M G Alviggi, M Aly, Y Amaral Coutinho, A Ambler, C Amelung, M Amerl, C G Ames, D Amidei, S P Amor Dos Santos, K R Amos, V Ananiev, C Anastopoulos, T Andeen, J K Anders, S Y Andrean, A Andreazza, S Angelidakis, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, E Antipov, M Antonelli, F Anulli, M Aoki, T Aoki, J A Aparisi Pozo, M A Aparo, L Aperio Bella, C Appelt, A Apyan, N Aranzabal, S J Arbiol Val, C Arcangeletti, A T H Arce, E Arena, J-F Arguin, S Argyropoulos, J-H Arling, O Arnaez, H Arnold, G Artoni, H Asada, K Asai, S Asai, N A Asbah, K Assamagan, R Astalos, S Atashi, R J Atkin, M Atkinson, H Atmani, P A Atmasiddha, K Augsten, S Auricchio, A D Auriol, V A Austrup, G Avolio, K Axiotis, G Azuelos, D Babal, H Bachacou, K Bachas, A Bachiu, F Backman, A Badea, T M Baer, P Bagnaia, M Bahmani, D Bahner, A J Bailey, V R Bailey, J T Baines, L Baines, O K Baker, E Bakos, D Bakshi Gupta, V Balakrishnan, R Balasubramanian, E M Baldin, P Balek, E Ballabene, F Balli, L M Baltes, W K Balunas, J Balz, E Banas, M Bandieramonte, A Bandyopadhyay, S Bansal, L Barak, M Barakat, E L Barberio, D Barberis, M Barbero, M Z Barel, K N Barends, T Barillari, M-S Barisits, T Barklow, P Baron, D A Baron Moreno, A Baroncelli, G Barone, A J Barr, J D Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, U Barron, M G Barros Teixeira, S Barsov, F Bartels, R Bartoldus, A E Barton, P Bartos, A Basan, M Baselga, A Bassalat, M J Basso, C R Basson, R L Bates, S Batlamous, J R Batley, B Batool, M Battaglia, D Battulga, M Bauce, M Bauer, P Bauer, L T Bazzano Hurrell, J B Beacham, T Beau, J Y Beaucamp, P H Beauchemin, P Bechtle, H P Beck, K Becker, A J Beddall, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, J F Beirer, F Beisiegel, M Belfkir, G Bella, L Bellagamba, A Bellerive, P Bellos, K Beloborodov, D Benchekroun, F Bendebba, Y Benhammou, M Benoit, S Bentvelsen, L Beresford, M Beretta, E Bergeaas Kuutmann, N Berger, B Bergmann, J Beringer, G Bernardi, C Bernius, F U Bernlochner, F Bernon, A Berrocal Guardia, T Berry, P Berta, A Berthold, I A Bertram, S Bethke, A Betti, A J Bevan, N K Bhalla, M Bhamjee, S Bhatta, D S Bhattacharya, P Bhattarai, V S Bhopatkar, R Bi, R M Bianchi, G Bianco, O Biebel, R Bielski, M Biglietti, M Bindi, A Bingul, C Bini, A Biondini, C J Birch-Sykes, G A Bird, M Birman, M Biros, S Biryukov, T Bisanz, E Bisceglie, J P Biswal, D Biswas, A Bitadze, K Bjørke, I Bloch, A Blue, U Blumenschein, J Blumenthal, G J Bobbink, V S Bobrovnikov, M Boehler, B Boehm, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, M Bomben, M Bona, M Boonekamp, C D Booth, A G Borbély, I S Bordulev, H M Borecka-Bielska, G Borissov, D Bortoletto, D Boscherini, M Bosman, J D Bossio Sola, K Bouaouda, N Bouchhar, J Boudreau, E V Bouhova-Thacker, D Boumediene, R Bouquet, A Boveia, J Boyd, D Boye, I R Boyko, J Bracinik, N Brahimi, G Brandt, O Brandt, F Braren, B Brau, J E Brau, R Brener, L Brenner, R Brenner, S Bressler, D Britton, D Britzger, I Brock, G Brooijmans, W K Brooks, E Brost, L M Brown, L E Bruce, T L Bruckler, P A Bruckman de Renstrom, B Brüers, A Bruni, G Bruni, M Bruschi, N Bruscino, T Buanes, Q Buat, D Buchin, A G Buckley, O Bulekov, B A Bullard, S Burdin, C D Burgard, A M Burger, B Burghgrave, O Burlayenko, J T P Burr, C D Burton, J C Burzynski, E L Busch, V Büscher, P J Bussey, J M Butler, C M Buttar, J M Butterworth, W Buttinger, C J Buxo Vazquez, A R Buzykaev, S Cabrera Urbán, L Cadamuro, D Caforio, H Cai, Y Cai, Y Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, G Calderini, P Calfayan, G Callea, L P Caloba, D Calvet, S Calvet, M Calvetti, R Camacho Toro, S Camarda, D Camarero Munoz, P Camarri, M T Camerlingo, D Cameron, C Camincher, M Campanelli, A Camplani, V Canale, A Canesse, J Cantero, Y Cao, F Capocasa, M Capua, A Carbone, R Cardarelli, J C J Cardenas, F Cardillo, G Carducci, T Carli, G Carlino, J I Carlotto, B T Carlson, E M Carlson, L Carminati, A Carnelli, M Carnesale, S Caron, E Carquin, S Carrá, G Carratta, F Carrio Argos, J W S Carter, T M Carter, M P Casado, M Caspar, F L Castillo, L Castillo Garcia, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, V Cavaliere, N Cavalli, V Cavasinni, Y C Cekmecelioglu, E Celebi, F Celli, M S Centonze, V Cepaitis, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, B Cervato, A Cervelli, G Cesarini, S A Cetin, D Chakraborty, J Chan, W Y Chan, J D Chapman, E Chapon, B Chargeishvili, D G Charlton, M Chatterjee, C Chauhan, S Chekanov, S V Chekulaev, G A Chelkov, A Chen, B Chen, B Chen, H Chen, H Chen, J Chen, J Chen, M Chen, S Chen, S J Chen, X Chen, X Chen, Y Chen, C L Cheng, H C Cheng, S Cheong, A Cheplakov, E Cheremushkina, E Cherepanova, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, N Chiedde, G Chiodini, A S Chisholm, A Chitan, M Chitishvili, M V Chizhov, K Choi, A R Chomont, Y Chou, E Y S Chow, T Chowdhury, K L Chu, M C Chu, X Chu, J Chudoba, J J Chwastowski, D Cieri, K M Ciesla, V Cindro, A Ciocio, F Cirotto, Z H Citron, M Citterio, D A Ciubotaru, A Clark, P J Clark, C Clarry, J M Clavijo Columbie, S E Clawson, C Clement, J Clercx, Y Coadou, M Cobal, A Coccaro, R F Coelho Barrue, R Coelho Lopes De Sa, S Coelli, A E C Coimbra, B Cole, J Collot, P Conde Muiño, M P Connell, S H Connell, I A Connelly, E I Conroy, F Conventi, H G Cooke, A M Cooper-Sarkar, A Cordeiro Oudot Choi, L D Corpe, M Corradi, F Corriveau, A Cortes-Gonzalez, M J Costa, F Costanza, D Costanzo, B M Cote, G Cowan, K Cranmer, D Cremonini, S Crépé-Renaudin, F Crescioli, M Cristinziani, M Cristoforetti, V Croft, J E Crosby, G Crosetti, A Cueto, T Cuhadar Donszelmann, H Cui, Z Cui, W R Cunningham, F Curcio, P Czodrowski, M M Czurylo, M J Da Cunha Sargedas De Sousa, J V Da Fonseca Pinto, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, D Dal Santo, C Dallapiccola, M Dam, G D'amen, V D'Amico, J Damp, J R Dandoy, M Danninger, V Dao, G Darbo, S Darmora, S J Das, S D'Auria, C David, T Davidek, B Davis-Purcell, I Dawson, H A Day-Hall, K De, R De Asmundis, N De Biase, S De Castro, N De Groot, P de Jong, H De la Torre, A De Maria, A De Salvo, U De Sanctis, F De Santis, A De Santo, J B De Vivie De Regie, D V Dedovich, J Degens, A M Deiana, F Del Corso, J Del Peso, F Del Rio, L Delagrange, F Deliot, C M Delitzsch, M Della Pietra, D Della Volpe, A Dell'Acqua, L Dell'Asta, M Delmastro, P A Delsart, S Demers, M Demichev, S P Denisov, L D'Eramo, D Derendarz, F Derue, P Dervan, K Desch, C Deutsch, F A Di Bello, A Di Ciaccio, L Di Ciaccio, A Di Domenico, C Di Donato, A Di Girolamo, G Di Gregorio, A Di Luca, B Di Micco, R Di Nardo, C Diaconu, M Diamantopoulou, F A Dias, T Dias Do Vale, M A Diaz, F G Diaz Capriles, M Didenko, E B Diehl, L Diehl, S Díez Cornell, C Diez Pardos, C Dimitriadi, A Dimitrievska, J Dingfelder, I-M Dinu, S J Dittmeier, F Dittus, F Djama, T Djobava, C Doglioni, A Dohnalova, J Dolejsi, Z Dolezal, K M Dona, M Donadelli, B Dong, J Donini, A D'Onofrio, M D'Onofrio, J Dopke, A Doria, N Dos Santos Fernandes, P Dougan, M T Dova, A T Doyle, M A Draguet, E Dreyer, I Drivas-Koulouris, M Drnevich, A S Drobac, M Drozdova, D Du, T A du Pree, F Dubinin, M Dubovsky, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, E R Duden, M D'uffizi, L Duflot, M Dührssen, A E Dumitriu, M Dunford, S Dungs, K Dunne, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, B L Dwyer, G I Dyckes, M Dyndal, B S Dziedzic, Z O Earnshaw, G H Eberwein, B Eckerova, S Eggebrecht, E Egidio Purcino De Souza, L F Ehrke, G Eigen, K Einsweiler, T Ekelof, P A Ekman, S El Farkh, Y El Ghazali, H El Jarrari, A El Moussaouy, V Ellajosyula, M Ellert, F Ellinghaus, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, I Ene, S Epari, P A Erland, M Errenst, M Escalier, C Escobar, E Etzion, G Evans, H Evans, L S Evans, M O Evans, A Ezhilov, S Ezzarqtouni, F Fabbri, L Fabbri, G Facini, V Fadeyev, R M Fakhrutdinov, D Fakoudis, S Falciano, L F Falda Ulhoa Coelho, P J Falke, J Faltova, C Fan, Y Fan, Y Fang, M Fanti, M Faraj, Z Farazpay, A Farbin, A Farilla, T Farooque, S M Farrington, F Fassi, D Fassouliotis, M Faucci Giannelli, W J Fawcett, L Fayard, P Federic, P Federicova, O L Fedin, G Fedotov, M Feickert, L Feligioni, D E Fellers, C Feng, M Feng, Z Feng, M J Fenton, A B Fenyuk, L Ferencz, R A M Ferguson, S I Fernandez Luengo, P Fernandez Martinez, M J V Fernoux, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D Ferrere, C Ferretti, F Fiedler, P Fiedler, A Filipčič, E K Filmer, F Filthaut, M C N Fiolhais, L Fiorini, W C Fisher, T Fitschen, P M Fitzhugh, I Fleck, P Fleischmann, T Flick, M Flores, L R Flores Castillo, L Flores Sanz De Acedo, F M Follega, N Fomin, J H Foo, A Formica, A C Forti, E Fortin, A W Fortman, M G Foti, L Fountas, D Fournier, H Fox, P Francavilla, S Francescato, S Franchellucci, M Franchini, S Franchino, D Francis, L Franco, V Franco Lima, L Franconi, M Franklin, G Frattari, A C Freegard, W S Freund, Y Y Frid, J Friend, N Fritzsche, A Froch, D Froidevaux, J A Frost, Y Fu, S Fuenzalida Garrido, M Fujimoto, K Y Fung, E Furtado De Simas Filho, M Furukawa, J Fuster, A Gabrielli, A Gabrielli, P Gadow, G Gagliardi, L G Gagnon, E J Gallas, B J Gallop, K K Gan, S Ganguly, Y Gao, F M Garay Walls, B Garcia, C García, A Garcia Alonso, A G Garcia Caffaro, J E García Navarro, M Garcia-Sciveres, G L Gardner, R W Gardner, N Garelli, D Garg, R B Garg, J M Gargan, C A Garner, C M Garvey, P Gaspar, V K Gassmann, G Gaudio, V Gautam, P Gauzzi, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, A A Geanta, C M Gee, A Gekow, C Gemme, M H Genest, S Gentile, A D Gentry, S George, W F George, T Geralis, P Gessinger-Befurt, M E Geyik, M Ghani, M Ghneimat, K Ghorbanian, A Ghosal, A Ghosh, A Ghosh, B Giacobbe, S Giagu, T Giani, P Giannetti, A Giannini, S M Gibson, M Gignac, D T Gil, A K Gilbert, B J Gilbert, D Gillberg, G Gilles, N E K Gillwald, L Ginabat, D M Gingrich, M P Giordani, P F Giraud, G Giugliarelli, D Giugni, F Giuli, I Gkialas, L K Gladilin, C Glasman, G R Gledhill, G Glemža, M Glisic, I Gnesi, Y Go, M Goblirsch-Kolb, B Gocke, D Godin, B Gokturk, S Goldfarb, T Golling, M G D Gololo, D Golubkov, J P Gombas, A Gomes, G Gomes Da Silva, A J Gomez Delegido, R Gonçalo, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, R Y González Andana, S González de la Hoz, R Gonzalez Lopez, C Gonzalez Renteria, M V Gonzalez Rodrigues, R Gonzalez Suarez, S Gonzalez-Sevilla, G R Gonzalvo Rodriguez, L Goossens, B Gorini, E Gorini, A Gorišek, T C Gosart, A T Goshaw, M I Gostkin, S Goswami, C A Gottardo, S A Gotz, M Gouighri, V Goumarre, A G Goussiou, N Govender, I Grabowska-Bold, K Graham, E Gramstad, S Grancagnolo, M Grandi, C M Grant, P M Gravila, F G Gravili, H M Gray, M Greco, C Grefe, I M Gregor, P Grenier, S G Grewe, C Grieco, A A Grillo, K Grimm, S Grinstein, J-F Grivaz, E Gross, J Grosse-Knetter, C Grud, J C Grundy, L Guan, W Guan, C Gubbels, J G R Guerrero Rojas, G Guerrieri, F Guescini, R Gugel, J A M Guhit, A Guida, E Guilloton, S Guindon, F Guo, J Guo, L Guo, Y Guo, R Gupta, R Gupta, S Gurbuz, S S Gurdasani, G Gustavino, M Guth, P Gutierrez, L F Gutierrez Zagazeta, M Gutsche, C Gutschow, C Gwenlan, C B Gwilliam, E S Haaland, A Haas, M Habedank, C Haber, H K Hadavand, A Hadef, S Hadzic, A I Hagan, J J Hahn, E H Haines, M Haleem, J Haley, J J Hall, G D Hallewell, L Halser, K Hamano, M Hamer, G N Hamity, E J Hampshire, J Han, K Han, L Han, L Han, S Han, Y F Han, K Hanagaki, M Hance, D A Hangal, H Hanif, M D Hank, J B Hansen, P H Hansen, K Hara, D Harada, T Harenberg, S Harkusha, M L Harris, Y T Harris, J Harrison, N M Harrison, P F Harrison, N M Hartman, N M Hartmann, Y Hasegawa, R Hauser, C M Hawkes, R J Hawkings, Y Hayashi, S Hayashida, D Hayden, C Hayes, R L Hayes, C P Hays, J M Hays, H S Hayward, F He, M He, Y He, Y He, N B Heatley, V Hedberg, A L Heggelund, N D Hehir, C Heidegger, K K Heidegger, W D Heidorn, J Heilman, S Heim, T Heim, J G Heinlein, J J Heinrich, L Heinrich, J Hejbal, L Helary, A Held, S Hellesund, C M Helling, S Hellman, R C W Henderson, L Henkelmann, A M Henriques Correia, H Herde, Y Hernández Jiménez, L M Herrmann, T Herrmann, G Herten, R Hertenberger, L Hervas, M E Hesping, N P Hessey, H Hibi, E Hill, S J Hillier, J R Hinds, F Hinterkeuser, M Hirose, S Hirose, D Hirschbuehl, T G Hitchings, B Hiti, J Hobbs, R Hobincu, N Hod, M C Hodgkinson, B H Hodkinson, A Hoecker, D D Hofer, J Hofer, T Holm, M Holzbock, L B A H Hommels, B P Honan, J Hong, T M Hong, B H Hooberman, W H Hopkins, Y Horii, S Hou, A S Howard, J Howarth, J Hoya, M Hrabovsky, A Hrynevich, T Hryn'ova, P J Hsu, S-C Hsu, Q Hu, Y F Hu, S Huang, X Huang, X Huang, Y Huang, Y Huang, Z Huang, Z Hubacek, M Huebner, F Huegging, T B Huffman, C A Hugli, M Huhtinen, S K Huiberts, R Hulsken, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, J P Iddon, P Iengo, R Iguchi, T Iizawa, Y Ikegami, N Ilic, H Imam, M Ince Lezki, T Ingebretsen Carlson, G Introzzi, M Iodice, V Ippolito, R K Irwin, M Ishino, W Islam, C Issever, S Istin, H Ito, J M Iturbe Ponce, R Iuppa, A Ivina, J M Izen, V Izzo, P Jacka, P Jackson, R M Jacobs, B P Jaeger, C S Jagfeld, G Jain, P Jain, K Jakobs, T Jakoubek, J Jamieson, K W Janas, M Javurkova, F Jeanneau, L Jeanty, J Jejelava, P Jenni, C E Jessiman, S Jézéquel, C Jia, J Jia, X Jia, X Jia, Z Jia, S Jiggins, J Jimenez Pena, S Jin, A Jinaru, O Jinnouchi, P Johansson, K A Johns, J W Johnson, D M Jones, E Jones, P Jones, R W L Jones, T J Jones, H L Joos, R Joshi, J Jovicevic, X Ju, J J Junggeburth, T Junkermann, A Juste Rozas, M K Juzek, S Kabana, A Kaczmarska, M Kado, H Kagan, M Kagan, A Kahn, A Kahn, C Kahra, T Kaji, E Kajomovitz, N Kakati, I Kalaitzidou, C W Kalderon, A Kamenshchikov, N J Kang, D Kar, K Karava, M J Kareem, E Karentzos, I Karkanias, O Karkout, S N Karpov, Z M Karpova, V Kartvelishvili, A N Karyukhin, E Kasimi, J Katzy, S Kaur, K Kawade, M P Kawale, C Kawamoto, T Kawamoto, E F Kay, F I Kaya, S Kazakos, V F Kazanin, Y Ke, J M Keaveney, R Keeler, G V Kehris, J S Keller, A S Kelly, J J Kempster, K E Kennedy, P D Kennedy, O Kepka, B P Kerridge, S Kersten, B P Kerševan, S Keshri, L Keszeghova, S Ketabchi Haghighat, R A Khan, A Khanov, A G Kharlamov, T Kharlamova, E E Khoda, M Kholodenko, T J Khoo, G Khoriauli, J Khubua, Y A R Khwaira, A Kilgallon, D W Kim, Y K Kim, N Kimura, M K Kingston, A Kirchhoff, C Kirfel, F Kirfel, J Kirk, A E Kiryunin, C Kitsaki, O Kivernyk, M Klassen, C Klein, L Klein, M H Klein, M Klein, S B Klein, U Klein, P Klimek, A Klimentov, T Klioutchnikova, P Kluit, S Kluth, E Kneringer, T M Knight, A Knue, R Kobayashi, D Kobylianskii, S F Koch, M Kocian, P Kodyš, D M Koeck, P T Koenig, T Koffas, O Kolay, I Koletsou, T Komarek, K Köneke, A X Y Kong, T Kono, N Konstantinidis, P Kontaxakis, B Konya, R Kopeliansky, S Koperny, K Korcyl, K Kordas, A Korn, S Korn, I Korolkov, N Korotkova, B Kortman, O Kortner, S Kortner, W H Kostecka, V V Kostyukhin, A Kotsokechagia, A Kotwal, A Koulouris, A Kourkoumeli-Charalampidi, C Kourkoumelis, E Kourlitis, O Kovanda, R Kowalewski, W Kozanecki, A 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Undrus, G Unel, J Urban, P Urquijo, P Urrejola, G Usai, R Ushioda, M Usman, Z Uysal, V Vacek, B Vachon, K O H Vadla, T Vafeiadis, A Vaitkus, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, E Valiente Moreno, A Vallier, J A Valls Ferrer, D R Van Arneman, T R Van Daalen, A Van Der Graaf, P Van Gemmeren, M Van Rijnbach, S Van Stroud, I Van Vulpen, M Vanadia, W Vandelli, M Vandenbroucke, E R Vandewall, D Vannicola, L Vannoli, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, L Varriale, K E Varvell, M E Vasile, L Vaslin, G A Vasquez, A Vasyukov, F Vazeille, T Vazquez Schroeder, J Veatch, V Vecchio, M J Veen, I Veliscek, L M Veloce, F Veloso, S Veneziano, A Ventura, S Ventura Gonzalez, A Verbytskyi, M Verducci, C Vergis, M Verissimo De Araujo, W Verkerke, J C Vermeulen, C Vernieri, M Vessella, M C Vetterli, A Vgenopoulos, N Viaux Maira, T Vickey, O E Vickey Boeriu, G H A Viehhauser, L Vigani, M Villa, M Villaplana Perez, E M Villhauer, E Vilucchi, M G Vincter, G S Virdee, A Vishwakarma, A Visibile, C Vittori, I Vivarelli, E Voevodina, F Vogel, J C Voigt, P Vokac, Yu Volkotrub, J Von Ahnen, E Von Toerne, B Vormwald, V Vorobel, K Vorobev, M Vos, K Voss, J H Vossebeld, M Vozak, L Vozdecky, N Vranjes, M Vranjes Milosavljevic, M Vreeswijk, N K Vu, R Vuillermet, O Vujinovic, I Vukotic, S Wada, C Wagner, J M Wagner, W Wagner, S Wahdan, H Wahlberg, M Wakida, J Walder, R Walker, W Walkowiak, A Wall, T Wamorkar, A Z Wang, C Wang, C Wang, H Wang, J Wang, R-J Wang, R Wang, R Wang, S M Wang, S Wang, T Wang, W T Wang, W Wang, X Wang, X Wang, X Wang, Y Wang, Y Wang, Z Wang, Z Wang, Z Wang, A Warburton, R J Ward, N Warrack, S Waterhouse, A T Watson, H Watson, M F Watson, E Watton, G Watts, B M Waugh, C Weber, H A Weber, M S Weber, S M Weber, C Wei, Y Wei, A R Weidberg, E J Weik, J Weingarten, M Weirich, C Weiser, C J Wells, T Wenaus, B Wendland, T Wengler, N S Wenke, N Wermes, M Wessels, A M Wharton, A S White, A White, M J White, D Whiteson, L Wickremasinghe, W Wiedenmann, M Wielers, C Wiglesworth, D J Wilbern, H G Wilkens, D M Williams, H H Williams, S Williams, S Willocq, B J Wilson, P J Windischhofer, F I Winkel, F Winklmeier, B T Winter, J K Winter, M Wittgen, M Wobisch, Z Wolffs, J Wollrath, M W Wolter, H Wolters, A F Wongel, E L Woodward, S D Worm, B K Wosiek, K W Woźniak, S Wozniewski, K Wraight, C Wu, J Wu, M Wu, M Wu, S L Wu, X Wu, Y Wu, Z Wu, J Wuerzinger, T R Wyatt, B M Wynne, S Xella, L Xia, M Xia, J Xiang, M Xie, X Xie, S Xin, A Xiong, J Xiong, D Xu, H Xu, L Xu, R Xu, T Xu, Y Xu, Z Xu, Z Xu, B Yabsley, S Yacoob, Y Yamaguchi, E Yamashita, H Yamauchi, T Yamazaki, Y Yamazaki, J Yan, S Yan, Z Yan, H J Yang, H T Yang, S Yang, T Yang, X Yang, X Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, H Ye, H Ye, J Ye, S Ye, X Ye, Y Yeh, I Yeletskikh, B K Yeo, M R Yexley, P Yin, K Yorita, S Younas, C J S Young, C Young, C Yu, Y Yu, M Yuan, R Yuan, L Yue, M Zaazoua, B Zabinski, E Zaid, Z K Zak, T Zakareishvili, N Zakharchuk, S Zambito, J A Zamora Saa, J Zang, D Zanzi, O Zaplatilek, C Zeitnitz, H Zeng, J C Zeng, D T Zenger, O Zenin, T Ženiš, S Zenz, S Zerradi, D Zerwas, M Zhai, B Zhang, D F Zhang, J Zhang, J Zhang, K Zhang, L Zhang, P Zhang, R Zhang, S Zhang, S Zhang, T Zhang, X Zhang, X Zhang, Y Zhang, Y Zhang, Y Zhang, Z Zhang, Z Zhang, H Zhao, T Zhao, Y Zhao, Z Zhao, A Zhemchugov, J Zheng, K Zheng, X Zheng, Z Zheng, D Zhong, B Zhou, H Zhou, N Zhou, Y Zhou, Y Zhou, C G Zhu, J Zhu, Y Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, N I Zimine, J Zinsser, M Ziolkowski, L Živković, A Zoccoli, K Zoch, T G Zorbas, O Zormpa, W Zou, L Zwalinski
This Letter presents the first study of Higgs boson production in association with a vector boson (V=W or Z) in the fully hadronic qqbb final state using data recorded by the ATLAS detector at the LHC in proton-proton collisions at sqrt[s]=13  TeV and corresponding to an integrated luminosity of 137  fb^{-1}. The vector bosons and Higgs bosons are each reconstructed as large-radius jets and tagged using jet substructure techniques. Dedicated tagging algorithms exploiting b-tagging properties are used to identify jets consistent with Higgs bosons decaying into bb[over ¯]...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38613275/measurements-of-all-particle-energy-spectrum-and-mean-logarithmic-mass-of-cosmic-rays-from-0-3-to-30%C3%A2-pev-with-lhaaso-km2a
#27
JOURNAL ARTICLE
Zhen Cao, F Aharonian, Axikegu, Y X Bai, Y W Bao, D Bastieri, X J Bi, Y J Bi, W Bian, A V Bukevich, Q Cao, W Y Cao, Zhe Cao, J Chang, J F Chang, A M Chen, E S Chen, H X Chen, Liang Chen, Lin Chen, Long Chen, M J Chen, M L Chen, Q H Chen, S Chen, S H Chen, S Z Chen, T L Chen, Y Chen, N Cheng, Y D Cheng, M Y Cui, S W Cui, X H Cui, Y D Cui, B Z Dai, H L Dai, Z G Dai, Danzengluobu, X Q Dong, K K Duan, J H Fan, Y Z Fan, J Fang, J H Fang, K Fang, C F Feng, H Feng, L Feng, S H Feng, X T Feng, Y Feng, Y L Feng, S Gabici, B Gao, C D Gao, Q Gao, W Gao, W K Gao, M M Ge, L S Geng, G Giacinti, G H Gong, Q B Gou, M H Gu, F L Guo, X L Guo, Y Q Guo, Y Y Guo, Y A Han, M Hasan, H H He, H N He, J Y He, Y He, Y K Hor, B W Hou, C Hou, X Hou, H B Hu, Q Hu, S C Hu, D H Huang, T Q Huang, W J Huang, X T Huang, X Y Huang, Y Huang, X L Ji, H Y Jia, K Jia, K Jiang, X W Jiang, Z J Jiang, M Jin, M M Kang, I Karpikov, D Kuleshov, K Kurinov, B B Li, C M Li, Cheng Li, Cong Li, D Li, F Li, H B Li, H C Li, Jian Li, Jie Li, K Li, S D Li, W L Li, W L Li, X R Li, Xin Li, Y Z Li, Zhe Li, Zhuo Li, E W Liang, Y F Liang, S J Lin, B Liu, C Liu, D Liu, D B Liu, H Liu, H D Liu, J Liu, J L Liu, M Y Liu, R Y Liu, S M Liu, W Liu, Y Liu, Y N Liu, Q Luo, Y Luo, H K Lv, B Q Ma, L L Ma, X H Ma, J R Mao, Z Min, W Mitthumsiri, H J Mu, Y C Nan, A Neronov, L J Ou, P Pattarakijwanich, Z Y Pei, J C Qi, M Y Qi, B Q Qiao, J J Qin, A Raza, D Ruffolo, A Sáiz, M Saeed, D Semikoz, L Shao, O Shchegolev, X D Sheng, F W Shu, H C Song, Yu V Stenkin, V Stepanov, Y Su, D X Sun, Q N Sun, X N Sun, Z B Sun, J Takata, P H T Tam, Q W Tang, R Tang, Z B Tang, W W Tian, C Wang, C B Wang, G W Wang, H G Wang, H H Wang, J C Wang, Kai Wang, Kai Wang, L P Wang, L Y Wang, P H Wang, R Wang, W Wang, X G Wang, X Y Wang, Y Wang, Y D Wang, Y J Wang, Z H Wang, Z X Wang, Zhen Wang, Zheng Wang, D M Wei, J J Wei, Y J Wei, T Wen, C Y Wu, H R Wu, Q W Wu, S Wu, X F Wu, Y S Wu, S Q Xi, J Xia, G M Xiang, D X Xiao, G Xiao, Y L Xin, Y Xing, D R Xiong, Z Xiong, D L Xu, R F Xu, R X Xu, W L Xu, L Xue, D H Yan, J Z Yan, T Yan, C W Yang, C Y Yang, F Yang, F F Yang, L L Yang, M J Yang, R Z Yang, W X Yang, Y H Yao, Z G Yao, L Q Yin, N Yin, X H You, Z Y You, Y H Yu, Q Yuan, H Yue, H D Zeng, T X Zeng, W Zeng, M Zha, B B Zhang, F Zhang, H Zhang, H M Zhang, H Y Zhang, J L Zhang, Li Zhang, P F Zhang, P P Zhang, R Zhang, S B Zhang, S R Zhang, S S Zhang, X Zhang, X P Zhang, Y F Zhang, Yi Zhang, Yong Zhang, B Zhao, J Zhao, L Zhao, L Z Zhao, S P Zhao, X H Zhao, F Zheng, W J Zhong, B Zhou, H Zhou, J N Zhou, M Zhou, P Zhou, R Zhou, X X Zhou, X X Zhou, B Y Zhu, C G Zhu, F R Zhu, H Zhu, K J Zhu, Y C Zou, X Zuo
We present the measurements of all-particle energy spectrum and mean logarithmic mass of cosmic rays in the energy range of 0.3-30 PeV using data collected from LHAASO-KM2A between September 2021 and December 2022, which is based on a nearly composition-independent energy reconstruction method, achieving unprecedented accuracy. Our analysis reveals the position of the knee at 3.67±0.05±0.15  PeV. Below the knee, the spectral index is found to be -2.7413±0.0004±0.0050, while above the knee, it is -3...
March 29, 2024: Physical Review Letters
https://read.qxmd.com/read/38612943/boosting-clear-cell-renal-carcinoma-specific-drug-discovery-using-a-deep-learning-algorithm-and-single-cell-analysis
#28
JOURNAL ARTICLE
Yishu Wang, Xiaomin Chen, Ningjun Tang, Mengyao Guo, Dongmei Ai
Clear cell renal carcinoma (ccRCC), the most common subtype of renal cell carcinoma, has the high heterogeneity of a highly complex tumor microenvironment. Existing clinical intervention strategies, such as target therapy and immunotherapy, have failed to achieve good therapeutic effects. In this article, single-cell transcriptome sequencing (scRNA-seq) data from six patients downloaded from the GEO database were adopted to describe the tumor microenvironment (TME) of ccRCC, including its T cells, tumor-associated macrophages (TAMs), endothelial cells (ECs), and cancer-associated fibroblasts (CAFs)...
April 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38612457/enhanced-therapeutic-potential-of-hybrid-exosomes-loaded-with-paclitaxel-for-cancer-therapy
#29
JOURNAL ARTICLE
Xuan Wang, Dongdong Li, Gaotian Li, Jinda Chen, Yi Yang, Lijun Bian, Jingying Zhou, Yongge Wu, Yan Chen
The advancement of exosome studies has positioned engineered exosomes as crucial biomaterials for the development of advanced drug delivery systems. This study focuses on developing a hybrid exosome system by fusing mesenchymal stem cells (MSCs) exosomes with folate-targeted liposomes. The aim was to improve the drug loading capacity and target modification of exosome nanocarriers for delivering the first-line chemotherapy drug paclitaxel (PTX) and its effectiveness was assessed through cellular uptake studies to evaluate its ability to deliver drugs to tumor cells in vitro...
March 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38612413/parp14-contributes-to-the-development-of-the-tumor-associated-macrophage-phenotype
#30
JOURNAL ARTICLE
Isotta Sturniolo, Csongor Váróczy, Zsolt Regdon, Anett Mázló, Szabolcs Muzsai, Attila Bácsi, Giorgia Intili, Csaba Hegedűs, Mark R Boothby, Jacob Holechek, Dana Ferraris, Herwig Schüler, László Virág
Cancers reprogram macrophages (MΦs) to a tumor-growth-promoting TAM (tumor-associated MΦ) phenotype that is similar to the anti-inflammatory M2 phenotype. Poly(ADP-ribose) polymerase (PARP) enzymes regulate various aspects of MΦ biology, but their role in the development of TAM phenotype has not yet been investigated. Here, we show that the multispectral PARP inhibitor (PARPi) PJ34 and the PARP14 specific inhibitor MCD113 suppress the expression of M2 marker genes in IL-4-polarized primary murine MΦs, in THP-1 monocytic human MΦs, and in primary human monocyte-derived MΦs...
March 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38611749/the-effect-of-salvianolic-acid-a-on-tumor-associated-macrophage-polarization-and-its-mechanisms-in-the-tumor-microenvironment-of-triple-negative-breast-cancer
#31
JOURNAL ARTICLE
Chao Tang, Shi-Ting Jiang, Cheng-Xia Li, Xiao-Fang Jia, Wen-Li Yang
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with a high degree of malignancy and poor prognosis. Tumor-associated macrophages (TAMs) have been identified as significant contributors to the growth and metastasis of TNBC through the secretion of various growth factors and chemokines. Salvianolic acid A (SAA) has been shown to have anti-cancer activities. However, the potential activity of SAA on re-polarized TAMs remains unclear. As there is a correlation between the TAMs and TNBC, this study investigates the effect of SAA on TAMs in the TNBC microenvironment...
March 26, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38605951/new-insights-into-the-role-of-macrophages-in-cancer-immunotherapy
#32
REVIEW
Li Zhou, Tiantian Zhao, Ruzhe Zhang, Chen Chen, Jiwei Li
Macrophages are the main component of the tumor microenvironment, which are differentiated from monocytes in the blood and play an important role in cancer development. Tumor-associated macrophages (TAMs) can promote tumor growth, invasion, metastasis, and resistance to anti-programmed death receptor 1 therapy by regulating programmed cell death ligand 1 expression and interacting with other immune cells in the tumor microenvironment. However, when activated properly, macrophages can also play an anti-tumor role by enhancing the phagocytosis and cytotoxicity of tumor cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605522/a-social-work-analysis-of-facilitators-of-and-barriers-to-adopting-technology-in-older-adults-a-systematic-literature-review
#33
JOURNAL ARTICLE
Ismael Ruiz-Figueroa, M Ángeles Minguela, Pilar Munuera
Increasing concern within social work about delivering comprehensive and high-quality care to older adults necessitates exploring their interest in information and communication technologies. The aim is to determine, via a systematic review using the PRISMA method, how the scientific literature on older adults' technology experiences through the lens of the Technology Acceptance Model (TAM). The review differentiates between enabling factors and barriers that influence older adults' use and acceptance of technology from their own perspective...
April 11, 2024: Journal of Gerontological Social Work
https://read.qxmd.com/read/38605519/mrna-lnp-vaccine-induced-cd8-t-cells-protect-mice-from-lethal-sars-cov-2-infection-in-the-absence-of-specific-antibodies
#34
JOURNAL ARTICLE
Brian Montoya, Carolina R Melo-Silva, Lingjuan Tang, Samita Kafle, Peter Lidskiy, Csaba Bajusz, Máté Vadovics, Hiromi Muramatsu, Edit Abraham, Zoltan Lipinszki, Debotri Chatterjee, Gabrielle Scher, Juliana Benitez, Molly M H Sung, Ying K Tam, Nicholas J Catanzaro, Alexandra Schäfer, Raul Andino, Ralph S Baric, David R Martinez, Norbert Pardi, Luis J Sigal
The role of CD8+ T-cells in SARS-CoV-2 pathogenesis or mRNA-LNP vaccine-induced protection from lethal COVID-19 is unclear. Using mouse-adapted SARS-CoV-2 virus (MA30) in C57BL/6 mice, we show that CD8+ T-cells are unnecessary for the intrinsic resistance of female or the susceptibility of male mice to lethal SARS-CoV-2 infection. Also, mice immunized with a di-proline prefusion-stabilized full-length SARS-CoV-2 Spike (S-2P) mRNA-LNP vaccine, which induces Spike-specific antibodies and CD8+ T-cells specific for the Spike-derived VNFNFNGL peptide, are protected from SARS-CoV-2 infection-induced lethality and weight loss, while mice vaccinated with mRNA-LNPs encoding only VNFNFNGL are protected from lethality but not weight loss...
April 10, 2024: Molecular Therapy
https://read.qxmd.com/read/38604990/conditional-deficiency-of-rho-associated-kinases-disrupts-endothelial-cell-junctions-and-impairs-respiratory-function-in-adult-mice
#35
JOURNAL ARTICLE
Takahiro Akamine, Takeshi Terabayashi, Takako Sasaki, Riku Hayashi, Ichitaro Abe, Fumihiro Hirayama, Shin-Ichi Nureki, Masahito Ikawa, Haruhiko Miyata, Akinori Tokunaga, Takashi Kobayashi, Katsuhiro Hanada, Dean Thumkeo, Shuh Narumiya, Toshimasa Ishizaki
The Ras homology (Rho) family of GTPases serves various functions, including promotion of cell migration, adhesion, and transcription, through activation of effector molecule targets. One such pair of effectors, the Rho-associated coiled-coil kinases (ROCK1 and ROCK2), induce reorganization of actin cytoskeleton and focal adhesion through substrate phosphorylation. Studies on ROCK knockout mice have confirmed that ROCK proteins are essential for embryonic development, but their physiological functions in adult mice remain unknown...
April 11, 2024: FEBS Open Bio
https://read.qxmd.com/read/38604557/oral-application-of-magnesium-l-threonate-alleviates-radicular-pain-by-inhibiting-neuro-inflammation-dependent-central-sensitization-of-rats
#36
JOURNAL ARTICLE
Siyuan Li, Hongjian Yi, Fuli Yuan, Xuejuan Zhang, Yi Zhong, Yangliang Huang
BACKGROUND: We have reported neuro-inflammation is involved in radicular pain by enhancing the efficiency of pain synaptic transmission in spinal level. Recently, peers' studies have confirmed that magnesium deficiency leads to neuro-inflammation, thus contributes to memory and emotional deficits and pain hypersensitivity in antineoplastic agents treated rats. In this study, we explore the effect of oral application of magnesium-L-threonate (L-TAMS) in radicular pain induced by lumbar disc herniation (LDH) of rats and the possible mechanisms...
April 9, 2024: Brain Research
https://read.qxmd.com/read/38603777/usability-and-feasibility-evaluation-of-a-web-based-and-offline-cybersecurity-resource-for-health-care-organizations-the-essentials-of-cybersecurity-in-health-care-organizations-framework-resource-mixed-methods-study
#37
JOURNAL ARTICLE
Niki O'Brien, Roberto Fernandez Crespo, Fiona O'Driscoll, Mabel Prendergast, Deeph Chana, Ara Darzi, Saira Ghafur
BACKGROUND: Cybersecurity is a growing challenge for health systems worldwide as the rapid adoption of digital technologies has led to increased cyber vulnerabilities with implications for patients and health providers. It is critical to develop workforce awareness and training as part of a safety culture and continuous improvement within health care organizations. However, there are limited open-access, health care-specific resources to help organizations at different levels of maturity develop their cybersecurity practices...
April 11, 2024: JMIR Formative Research
https://read.qxmd.com/read/38602536/tumor-associated-macrophage-derived-exosomal-mir21-5p-promotes-tumor-angiogenesis-by-regulating-yap1-hif-1%C3%AE-axis-in-head-and-neck-squamous-cell-carcinoma
#38
JOURNAL ARTICLE
Quan Yan, Jing Liu, Yiding Liu, Zhihao Wen, Dong Jin, Fu Wang, Lu Gao
Extracellular vesicles (EVs) have recently received increasing attention as essential mediators of communication between tumor cells and their microenvironments. Tumor-associated macrophages (TAMs) play a proangiogenic role in various tumors, especially head and neck squamous cell carcinoma (HNSCC), and angiogenesis is closely related to tumor growth and metastasis. This research focused on exploring the mechanisms by which EVs derived from TAMs modulate tumor angiogenesis in HNSCC. Our results indicated that TAMs infiltration correlated positively with microvascular density in HNSCC...
April 11, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38602417/a-phase-1-study-of-kin-3248-an-irreversible-small-molecule-pan-fgfr-inhibitor-in-patients-with-advanced-fgfr-2-3-driven-solid-tumors
#39
JOURNAL ARTICLE
Benjamin Garmezy, Mitesh J Borad, Rastislav Bahleda, Cesar A Perez, Li-Tzong Chen, Shumei Kato, Do-Youn Oh, Paul Severson, Betty Y Tam, Cheng Quah, James J Harding
BACKGROUND: Despite efficacy of approved FGFR inhibitors, emergence of polyclonal secondary mutations in the FGFR kinase domain leads to acquired resistance. KIN-3248 is a selective, irreversible, orally bioavailable, small molecule inhibitor of FGFR1-4 that blocks both primary oncogenic and secondary kinase domain resistance FGFR alterations. MATERIALS AND METHODS: A first-in-human, Phase 1 study of KIN-3248 was conducted in advanced solid tumors patients harboring FGFR2 and/or FGFR3 gene alterations (NCT05242822)...
April 11, 2024: Cancer Res Commun
https://read.qxmd.com/read/38600892/a-randomized-evaluation-of-moodfx-a-patient-centred-e-health-tool-to-support-outcome-measurement-for-depression-une-%C3%A3-valuation-randomis%C3%A3-e-de-moodfx-un-outil-de-sant%C3%A3-en-ligne-centr%C3%A3-sur-le-patient-pour-soutenir-la-mesure-du-r%C3%A3-sultat-dans-la-d%C3%A3-pression
#40
JOURNAL ARTICLE
Victor W Li, Jaspreet Sahota, Deea K Dev, Dib D Gill, Vanessa C Evans, Auby Axler, Trisha Chakrabarty, André Do, Kamyar Keramatian, John-Jose Nunez, Edwin M Tam, Lakshmi N Yatham, Erin E Michalak, Jill K Murphy, Raymond W Lam
BACKGROUND: e-Health tools using validated questionnaires to assess outcomes may facilitate measurement-based care for psychiatric disorders. MoodFX was created as a free online symptom tracker to support patients for outcome measurement in their depression treatment. We conducted a pilot randomized evaluation to examine its usability, and clinical utility. METHODS: Patients presenting with a major depressive episode (within a major depressive or bipolar disorder) were randomly assigned to receive either MoodFX or a health information website as the intervention and control condition, respectively, with follow-up assessment surveys conducted online at baseline, 8 weeks and 6 months...
April 11, 2024: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
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