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Q L Gui, Y S Wang, S Huang, Y Wan, H P Wang, Z G Zhu, M M Li, H Y Zhu, Q S Tao, Y Y Shen, Q Zhang, H Qin
Objective: To investigate the clinical significance of tumor associated macrophages (TAM) in multiple myeloma (MM) and the relationship with angiogenesis and immunosuppression. Methods: Seventy cases of MM patients diagnosed from August 2015 to June 2017 were enrolled in the study as experimental group, 20 cases of benign hematological diseases (13 with iron deficiency anemia and 7 with megaloblastic anemia) patients as control group. Immunohistochemical method was used to detect the expression of CD163, CD34 and VEGF in bone marrow samples, and flow cytometry was used to detect the proportion of regulatory T cell (Treg cells), ELISA was used to detect the level of IL-10, and the clinical features were analyzed...
February 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Ngoc Huong Lien Ha, Mei Sian Chong, Robin Wai Munn Choo, Wai Jia Tam, Philip Lin Kiat Yap
BACKGROUND: Although foreign domestic workers (FDWs) play a significant role in caring for frail seniors in Singapore and are vulnerable to caregiving burden, there has been little research conducted hitherto. We explored caregiver burden and its determinants in this study. METHODS: FDWs (N = 221, M age = 32.3, SD = 6.23) recruited from a hospital geriatric unit completed the Zarit Burden Interview (ZBI) administered in English, Bahasa Melayu, or Burmese. Univariate and multivariate regression were employed to investigate factors influencing caregiving burden in FDWs...
March 21, 2018: International Psychogeriatrics
Jon G Persichino, Argun D Can, Tam T Van, Michele N Matthews, Scott G Filler
Invasive pulmonary mucormycosis and aspergillosis are rare, life-threatening fungal infections. Most documented cases have been reported in non-cirrhotic patients with diabetes mellitus, neutropenia, or treatment with corticosteroids. The prevalence of each infection is low among patients with hepatic cirrhosis. We report the first likely case of combined invasive pulmonary mucormycosis and aspergillosis in a male with decompensated hepatic cirrhosis. This report also highlights the first non-diabetic case of invasive pulmonary mucormycosis with decompensated hepatic cirrhosis...
September 2018: Medical Mycology Case Reports
Rei-Lin Kuo, Chi-Jene Chen, Ee-Hong Tam, Chung-Guei Huang, Li-Hsin Li, Zong-Hua Li, Pei-Chia Su, Hao-Ping Liu, Chih-Ching Wu
Influenza A virus infections can result in severe respiratory diseases. The H7N9 subtype of avian influenza A virus has been transmitted to humans and caused severe disease and death. Nonstructural protein 1 (NS1) of influenza A virus is a virulence determinant during viral infection. To elucidate the functions of the NS1 encoded by influenza A H7N9 virus (H7N9 NS1), interaction partners of H7N9 NS1 in human cells were identified with immunoprecipitation followed by SDS-PAGE coupled with liquid chromatography-tandem mass spectrometry (GeLC-MS/MS)...
March 20, 2018: Journal of Proteome Research
Honglin Jin, Chao Wan, Zhenwei Zou, Guifang Zhao, Lingling Zhang, Yuanyuan Geng, Tong Chen, Ai Huang, Fagang Jiang, Jue-Ping Feng, Jonathan F Lovell, Jing Chen, Gang Wu, Kunyu Yang
Immunosuppressive tumor microenvironments (TMEs) create tremendous obstacles for an effective cancer therapy. Herein, we developed a melittin-RADA32 hybrid peptide hydrogel loaded with doxorubicin (DOX) for a potent chemoimmunotherapy against melanoma through the active regulation of TMEs. The formed melittin-RADA32-DOX (MRD) hydrogel has an interweaving nanofiber structure and exhibits excellent biocompatibility, controlled drug release properties both in vitro and in vivo, and an enhanced killing effect to melanoma cells...
March 20, 2018: ACS Nano
Lars Wilkinson, Barnaby Hunt, Pierre Johansen, Neeraj N Iyer, Tam Dang-Tan, Richard F Pollock
INTRODUCTION: The National Health and Nutrition Examination Surveys show that many people with type 2 diabetes (T2D) in the USA fail to achieve recommended treatment targets. In the SUSTAIN 7 randomized controlled trial, once-weekly semaglutide (0.5 and 1.0 mg) was superior to comparative doses of dulaglutide (0.75 and 1.5 mg) in reducing glycated hemoglobin (HbA1c) and body weight in people with T2D. The present study estimated the cost per patient achieving HbA1c treatment targets and weight loss responses with once-weekly semaglutide and dulaglutide in the USA...
March 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Keiji Yasuda, Tam Thanh Nguyen, Yoshiyuki Asakura
Cross-sectional area distribution of broadband noise in a sonochemical reactor was measured to estimate reaction fields. A needle-type hydrophone scanned the sonochemical reactor in horizontal and vertical directions at one-millimeter interval. To show an absolute value of broadband noise, average of broadband sound pressure was defined. The distribution of sound pressures at the fundamental and second harmonic frequencies were also measured. In the case of driving frequency at 130 kHz, sonochemical reaction fields were observed in several ellipse shapes...
May 2018: Ultrasonics Sonochemistry
Sarah E Gollust, Brooke A Cunningham, Barbara G Bokhour, Howard S Gordon, Charlene Pope, Somnath S Saha, Dina M Jones, Tam Do, Diana J Burgess
Progress to address health care equity requires health care providers' commitment, but their engagement may depend on their perceptions of the factors contributing to inequity. To understand providers' perceptions of causes of racial health care disparities, a short survey was delivered to health care providers who work at 3 Veterans Health Administration sites, followed by qualitative interviews (N = 53). Survey data indicated that providers attributed the causes of disparities to social and economic conditions more than to patients' or providers' behaviors...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
Chunmei Piao, Wen-Mei Zhang, Tao-Tao Li, Cong-Cong Zhang, Shulan Qiu, Yan Liu, Sa Liu, Ming Jin, Li-Xin Jia, Wen-Chao Song, Jie Du
Inflammatory cells such as macrophages can play a pro-tumorigenic role in the tumor stroma. Tumor-associated macrophages (TAMs) generally display an M2 phenotype with tumor-promoting activity; however, the mechanisms regulating the TAM phenotype remain unclear. Complement 5a (C5a) is a cytokine-like polypeptide that is generated during complement system activation and is known to promote tumor growth. Herein, we investigated the role of C5a on macrophage polarization in colon cancer metastasis in mice. We found that deficiency of the C5a receptor (C5aR) severely impairs the metastatic ability of implanted colon cancer cells...
March 15, 2018: Experimental Cell Research
Kwang-Hyun Lee, Young-Hoon Jo, Sung-Jae Kim, Wan-Sun Choi, Chang-Hun Lee, Joo-Hak Kim
PURPOSE: The purpose of this study was to evaluate the clinical outcome of autogenous palmaris longus grafting for extensor tendon ruptures of 2 or more fingers in rheumatoid hands and to identify the factors related to the clinical outcome. METHODS: Between 2000 and 2013, a total 41 patients with advanced rheumatoid arthritis and multiple extensor tendon ruptures reconstructed with autogenous palmaris longus tendon grafts were reviewed. Extension lag at the metacarpophalangeal (MCP) joint, total active motion (TAM), and fingertip-to-palm (TTP) distance were evaluated at final follow-up...
March 15, 2018: Journal of Hand Surgery
Thai Hoang, Hong Nguyen, Ray W Shiraishi, Mai Nguyen, Trista Bingham, Diep Nguyen, Tam Nguyen, Hao Duong, Sheryl Lyss, Hien Tran
BACKGROUND: Methadone maintenance treatment (MMT) is highly effective for reducing heroin use and HIV transmission among people who inject opioids. We sought to measure and understand factors associated with continued heroin use, a critical factor affecting treatment outcome among MMT patients in Vietnam. METHOD: We collected data from medical charts of a nationally representative sample of patients who were on MMT from May 2008 to December 2013. We selected 10 MMT clinics using probability proportional to size and 50 patients/clinic by systematic random sampling...
March 15, 2018: International Journal on Drug Policy
Amer M Johri, Joshua Durbin, Joseph Newbigging, Robert Tanzola, Ryan Chow, Sabe De, James Tam
The development of small, user friendly, handheld ultrasound devices has stimulated the growth of cardiac point-of-care ultrasound (POCUS) for the purpose of rapid, bedside cardiac assessment. Medical schools have begun integrating cardiac POCUS into their curricula. In this review the authors summarize the variable approaches taken by several medical training programs with respect to duration of POCUS training, prerequisite knowledge, and methods of delivering these skills (including e-learning, hands-on training, and simulation)...
March 14, 2018: Journal of the American Society of Echocardiography
David Chi-Leung Lam, Hoi-Hin Kwok, Wai-Cho Yu, Fanny Wai-San Ko, Cheuk-Yin Tam, Arthur Chun-Wing Lau, Daniel Yee-Tak Fong, Mary Sau-Man Ip
BACKGROUND: Club cell protein-16 (CC16) expression has been associated with smoking-related lung function decline. The study hypothesis was that CC16 expression in both serum and bronchial epithelium is associated with lung function decline in smokers, and exposure to cigarette smoke will lead to reduction in CC16 expression in bronchial epithelial cells. METHODS: In a cohort of community-based male Chinese subjects recruited for lung function test in 2000, we reassessed their lung function ten years later and measured serum levels of CC16...
March 16, 2018: BMC Pulmonary Medicine
Davina Gale, Andrew R J Lawson, Karen Howarth, Mikidache Madi, Bradley Durham, Sarah Smalley, John Calaway, Shannon Blais, Greg Jones, James Clark, Peter Dimitrov, Michelle Pugh, Samuel Woodhouse, Michael Epstein, Ana Fernandez-Gonzalez, Alexandra S Whale, Jim F Huggett, Carole A Foy, Gerwyn M Jones, Hadas Raveh-Amit, Karin Schmitt, Alison Devonshire, Emma Green, Tim Forshew, Vincent Plagnol, Nitzan Rosenfeld
INTRODUCTION: Detection and monitoring of circulating tumor DNA (ctDNA) is rapidly becoming a diagnostic, prognostic and predictive tool in cancer patient care. A growing number of gene targets have been identified as diagnostic or actionable, requiring the development of reliable technology that provides analysis of multiple genes in parallel. We have developed the InVision™ liquid biopsy platform which utilizes enhanced TAm-Seq™ (eTAm-Seq™) technology, an amplicon-based next generation sequencing method for the identification of clinically-relevant somatic alterations at low frequency in ctDNA across a panel of 35 cancer-related genes...
2018: PloS One
A M Sirunyan, A Tumasyan, W Adam, F Ambrogi, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, J Grossmann, J Hrubec, M Jeitler, A König, N Krammer, I Krätschmer, D Liko, T Madlener, I Mikulec, E Pree, D Rabady, N Rad, H Rohringer, J Schieck, R Schöfbeck, M Spanring, D Spitzbart, W Waltenberger, J Wittmann, C-E Wulz, M Zarucki, V Chekhovsky, V Mossolov, J Suarez Gonzalez, E A De Wolf, D Di Croce, X Janssen, J Lauwers, H Van Haevermaet, P Van Mechelen, N Van Remortel, S Abu Zeid, F Blekman, J D'Hondt, I De Bruyn, J De Clercq, K Deroover, G Flouris, D Lontkovskyi, S Lowette, S Moortgat, L Moreels, Q Python, K Skovpen, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, H Brun, B Clerbaux, G De Lentdecker, H Delannoy, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, G Karapostoli, T Lenzi, J Luetic, T Maerschalk, A Marinov, A Randle-Conde, T Seva, C Vander Velde, P Vanlaer, D Vannerom, R Yonamine, F Zenoni, F Zhang, A Cimmino, T Cornelis, D Dobur, A Fagot, M Gul, I Khvastunov, D Poyraz, C Roskas, S Salva, M Tytgat, W Verbeke, N Zaganidis, H Bakhshiansohi, O Bondu, S Brochet, G Bruno, C Caputo, A Caudron, S De Visscher, C Delaere, M Delcourt, B Francois, A Giammanco, A Jafari, M Komm, G Krintiras, V Lemaitre, A Magitteri, A Mertens, M Musich, K Piotrzkowski, L Quertenmont, M Vidal Marono, S Wertz, N Beliy, W L Aldá Júnior, F L Alves, G A Alves, L Brito, M Correa Martins Junior, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, A Custódio, E M Da Costa, G G Da Silveira, D De Jesus Damiao, S Fonseca De Souza, L M Huertas Guativa, H Malbouisson, M Melo De Almeida, C Mora Herrera, L Mundim, H Nogima, A Santoro, A Sznajder, E J Tonelli Manganote, F Torres Da Silva De Araujo, A Vilela Pereira, S Ahuja, C A Bernardes, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, S F Novaes, Sandra S Padula, D Romero Abad, J C Ruiz Vargas, A Aleksandrov, R Hadjiiska, P Iaydjiev, M Misheva, M Rodozov, M Shopova, S Stoykova, G Sultanov, A Dimitrov, I Glushkov, L Litov, B Pavlov, P Petkov, W Fang, X Gao, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, Y Chen, C H Jiang, D Leggat, H Liao, Z Liu, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, E Yazgan, H Zhang, S Zhang, J Zhao, Y Ban, G Chen, Q Li, S Liu, Y Mao, S J Qian, D Wang, Z Xu, C Avila, A Cabrera, L F Chaparro Sierra, C Florez, C F González Hernández, J D Ruiz Alvarez, B Courbon, N Godinovic, D Lelas, I Puljak, P M Ribeiro Cipriano, T Sculac, Z Antunovic, M Kovac, V Brigljevic, D Ferencek, K Kadija, B Mesic, A Starodumov, T Susa, M W Ather, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, M Finger, M Finger, E Carrera Jarrin, Y Assran, M A Mahmoud, A Mahrous, R K Dewanjee, M Kadastik, L Perrini, M Raidal, A Tiko, C Veelken, P Eerola, J Pekkanen, M Voutilainen, J Härkönen, T Järvinen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Lehti, T Lindén, P Luukka, E Tuominen, J Tuominiemi, E Tuovinen, J Talvitie, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, J L Faure, F Ferri, S Ganjour, S Ghosh, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, I Kucher, E Locci, M Machet, J Malcles, G Negro, J Rander, A Rosowsky, M Ö Sahin, M Titov, A Abdulsalam, C Amendola, I Antropov, S Baffioni, F Beaudette, P Busson, L Cadamuro, C Charlot, R Granier de Cassagnac, M Jo, S Lisniak, A Lobanov, J Martin Blanco, M Nguyen, C Ochando, G Ortona, P Paganini, P Pigard, R Salerno, J B Sauvan, Y Sirois, A G Stahl Leiton, T Strebler, Y Yilmaz, A Zabi, A Zghiche, J-L Agram, J Andrea, D Bloch, J-M Brom, M Buttignol, E C Chabert, N Chanon, C Collard, E Conte, X Coubez, J-C Fontaine, D Gelé, U Goerlach, M Jansová, A-C Le Bihan, N Tonon, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fay, L Finco, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, A Popov, V Sordini, M Vander Donckt, S Viret, T Toriashvili, Z Tsamalaidze, C Autermann, L Feld, M K Kiesel, K Klein, M Lipinski, M Preuten, C Schomakers, J Schulz, T Verlage, V Zhukov, A Albert, E Dietz-Laursonn, D Duchardt, M Endres, M Erdmann, S Erdweg, T Esch, R Fischer, A Güth, M Hamer, T Hebbeker, C Heidemann, K Hoepfner, S Knutzen, M Merschmeyer, A Meyer, P Millet, S Mukherjee, T Pook, M Radziej, H Reithler, M Rieger, F Scheuch, D Teyssier, S Thüer, G Flügge, B Kargoll, T Kress, A Künsken, J Lingemann, T Müller, A Nehrkorn, A Nowack, C Pistone, O Pooth, A Stahl, M Aldaya Martin, T Arndt, C Asawatangtrakuldee, K Beernaert, O Behnke, U Behrens, A Bermúdez Martínez, A A Bin Anuar, K Borras, V Botta, A Campbell, P Connor, C Contreras-Campana, F Costanza, C Diez Pardos, G Eckerlin, D Eckstein, T Eichhorn, E Eren, E Gallo, J Garay Garcia, A Geiser, A Gizhko, J M Grados Luyando, A Grohsjean, P Gunnellini, M Guthoff, A Harb, J Hauk, M Hempel, H Jung, A Kalogeropoulos, M Kasemann, J Keaveney, C Kleinwort, I Korol, D Krücker, W Lange, A Lelek, T Lenz, J Leonard, K Lipka, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, G Mittag, J Mnich, A Mussgiller, E Ntomari, D Pitzl, A Raspereza, B Roland, M Savitskyi, P Saxena, R Shevchenko, S Spannagel, N Stefaniuk, G P Van Onsem, R Walsh, Y Wen, K Wichmann, C Wissing, O Zenaiev, S Bein, V Blobel, M Centis Vignali, T Dreyer, E Garutti, D Gonzalez, J Haller, A Hinzmann, M Hoffmann, A Karavdina, R Klanner, R Kogler, N Kovalchuk, S Kurz, T Lapsien, I Marchesini, D Marconi, M Meyer, M Niedziela, D Nowatschin, F Pantaleo, T Peiffer, A Perieanu, C Scharf, P Schleper, A Schmidt, S Schumann, J Schwandt, J Sonneveld, H Stadie, G Steinbrück, F M Stober, M Stöver, H Tholen, D Troendle, E Usai, L Vanelderen, A Vanhoefer, B Vormwald, M Akbiyik, C Barth, S Baur, E Butz, R Caspart, T Chwalek, F Colombo, W De Boer, A Dierlamm, B Freund, R Friese, M Giffels, D Haitz, F Hartmann, S M Heindl, U Husemann, F Kassel, S Kudella, H Mildner, M U Mozer, Th Müller, M Plagge, G Quast, K Rabbertz, M Schröder, I Shvetsov, G Sieber, H J Simonis, R Ulrich, S Wayand, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, V A Giakoumopoulou, A Kyriakis, D Loukas, I Topsis-Giotis, G Karathanasis, S Kesisoglou, A Panagiotou, N Saoulidou, K Kousouris, I Evangelou, C Foudas, P Kokkas, S Mallios, N Manthos, I Papadopoulos, E Paradas, J Strologas, F A Triantis, M Csanad, N Filipovic, G Pasztor, G I Veres, G Bencze, C Hajdu, D Horvath, Á Hunyadi, F Sikler, V Veszpremi, A J Zsigmond, N Beni, S Czellar, J Karancsi, A Makovec, J Molnar, Z Szillasi, M Bartók, P Raics, Z L Trocsanyi, B Ujvari, S Choudhury, J R Komaragiri, S Bahinipati, S Bhowmik, P Mal, K Mandal, A Nayak, D K Sahoo, N Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, R Chawla, N Dhingra, A K Kalsi, A Kaur, M Kaur, R Kumar, P Kumari, A Mehta, J B Singh, G Walia, Ashok Kumar, Aashaq Shah, A Bhardwaj, S Chauhan, B C Choudhary, R B Garg, S Keshri, A Kumar, S Malhotra, M Naimuddin, K Ranjan, R Sharma, R Bhardwaj, R Bhattacharya, S Bhattacharya, U Bhawandeep, S Dey, S Dutt, S Dutta, S Ghosh, N Majumdar, A Modak, K Mondal, S Mukhopadhyay, S Nandan, A Purohit, A Roy, D Roy, S Roy Chowdhury, S Sarkar, M Sharan, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, A K Mohanty, P K Netrakanti, L M Pant, P Shukla, A Topkar, T Aziz, S Dugad, B Mahakud, S Mitra, G B Mohanty, N Sur, B Sutar, S Banerjee, S Bhattacharya, S Chatterjee, P Das, M Guchait, Sa Jain, S Kumar, M Maity, G Majumder, K Mazumdar, T Sarkar, N Wickramage, S Chauhan, S Dube, V Hegde, A Kapoor, K Kothekar, S Pandey, A Rane, S Sharma, S Chenarani, E Eskandari Tadavani, S M Etesami, M Khakzad, M Mohammadi Najafabadi, M Naseri, S Paktinat Mehdiabadi, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, F Errico, L Fiore, G Iaselli, S Lezki, G Maggi, M Maggi, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, A Sharma, L Silvestris, R Venditti, P Verwilligen, G Abbiendi, C Battilana, D Bonacorsi, S Braibant-Giacomelli, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, D Fasanella, P Giacomelli, C Grandi, L Guiducci, S Marcellini, G Masetti, A Montanari, F L Navarria, A Perrotta, A M Rossi, T Rovelli, G P Siroli, N Tosi, S Albergo, S Costa, A Di Mattia, F Giordano, R Potenza, A Tricomi, C Tuve, G Barbagli, K Chatterjee, V Ciulli, C Civinini, R D'Alessandro, E Focardi, P Lenzi, M Meschini, S Paoletti, L Russo, G Sguazzoni, D Strom, L Viliani, L Benussi, S Bianco, F Fabbri, D Piccolo, F Primavera, V Calvelli, F Ferro, E Robutti, S Tosi, A Benaglia, L Brianza, F Brivio, V Ciriolo, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M Malberti, S Malvezzi, R A Manzoni, D Menasce, L Moroni, M Paganoni, K Pauwels, D Pedrini, S Pigazzini, S Ragazzi, N Redaelli, T Tabarelli de Fatis, S Buontempo, N Cavallo, S Di Guida, F Fabozzi, F Fienga, A O M Iorio, W A Khan, L Lista, S Meola, P Paolucci, C Sciacca, F Thyssen, P Azzi, N Bacchetta, L Benato, D Bisello, A Boletti, R Carlin, A Carvalho Antunes De Oliveira, P Checchia, P De Castro Manzano, T Dorigo, U Dosselli, F Gasparini, U Gasparini, A Gozzelino, S Lacaprara, M Margoni, A T Meneguzzo, N Pozzobon, P Ronchese, R Rossin, F Simonetto, E Torassa, M Zanetti, P Zotto, G Zumerle, A Braghieri, A Magnani, P Montagna, S P Ratti, V Re, M Ressegotti, C Riccardi, P Salvini, I Vai, P Vitulo, L Alunni Solestizi, M Biasini, G M Bilei, C Cecchi, D Ciangottini, L Fanò, P Lariccia, R Leonardi, E Manoni, G Mantovani, V Mariani, M Menichelli, A Rossi, A Santocchia, D Spiga, K Androsov, P Azzurri, G Bagliesi, T Boccali, L Borrello, R Castaldi, M A Ciocci, R Dell'Orso, G Fedi, L Giannini, A Giassi, M T Grippo, F Ligabue, T Lomtadze, E Manca, G Mandorli, L Martini, A Messineo, F Palla, A Rizzi, A Savoy-Navarro, P Spagnolo, R Tenchini, G Tonelli, A Venturi, P G Verdini, L Barone, F Cavallari, M Cipriani, D Del Re, E Di Marco, M Diemoz, S Gelli, E Longo, F Margaroli, B Marzocchi, P Meridiani, G Organtini, R Paramatti, F Preiato, S Rahatlou, C Rovelli, F Santanastasio, N Amapane, R Arcidiacono, S Argiro, M Arneodo, N Bartosik, R Bellan, C Biino, N Cartiglia, F Cenna, M Costa, R Covarelli, A Degano, N Demaria, B Kiani, C Mariotti, S Maselli, E Migliore, V Monaco, E Monteil, M Monteno, M M Obertino, L Pacher, N Pastrone, M Pelliccioni, G L Pinna Angioni, F Ravera, A Romero, M Ruspa, R Sacchi, K Shchelina, V Sola, A Solano, A Staiano, P Traczyk, S Belforte, M Casarsa, F Cossutti, G Della Ricca, A Zanetti, D H Kim, G N Kim, M S Kim, J Lee, S Lee, S W Lee, C S Moon, Y D Oh, S Sekmen, D C Son, Y C Yang, A Lee, H Kim, D H Moon, G Oh, J A Brochero Cifuentes, J Goh, T J Kim, S Cho, S Choi, Y Go, D Gyun, S Ha, B Hong, Y Jo, Y Kim, K Lee, K S Lee, S Lee, J Lim, S K Park, Y Roh, J Almond, J Kim, J S Kim, H Lee, K Lee, K Nam, S B Oh, B C Radburn-Smith, S H Seo, U K Yang, H D Yoo, G B Yu, M Choi, H Kim, J H Kim, J S H Lee, I C Park, Y Choi, C Hwang, J Lee, I Yu, V Dudenas, A Juodagalvis, J Vaitkus, I Ahmed, Z A Ibrahim, M A B Md Ali, F Mohamad Idris, W A T Wan Abdullah, M N Yusli, Z Zolkapli, R Reyes-Almanza, G Ramirez-Sanchez, M C Duran-Osuna, H Castilla-Valdez, E De La Cruz-Burelo, I Heredia-De La Cruz, R I Rabadan-Trejo, R Lopez-Fernandez, J Mejia Guisao, A Sanchez-Hernandez, S Carrillo Moreno, C Oropeza Barrera, F Vazquez Valencia, I Pedraza, H A Salazar Ibarguen, C Uribe Estrada, A Morelos Pineda, D Krofcheck, P H Butler, A Ahmad, M Ahmad, Q Hassan, H R Hoorani, A Saddique, M A Shah, M Shoaib, M Waqas, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, M Szleper, P Zalewski, K Bunkowski, A Byszuk, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, M Olszewski, A Pyskir, M Walczak, P Bargassa, C Beirão Da Cruz E Silva, A Di Francesco, P Faccioli, B Galinhas, M Gallinaro, J Hollar, N Leonardo, L Lloret Iglesias, M V Nemallapudi, J Seixas, G Strong, O Toldaiev, D Vadruccio, J Varela, S Afanasiev, P Bunin, M Gavrilenko, I Golutvin, I Gorbunov, A Kamenev, V Karjavin, A Lanev, A Malakhov, V Matveev, V Palichik, V Perelygin, S Shmatov, S Shulha, N Skatchkov, V Smirnov, N Voytishin, A Zarubin, Y Ivanov, V Kim, E Kuznetsova, P Levchenko, V Murzin, V Oreshkin, I Smirnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, A Karneyeu, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, I Pozdnyakov, G Safronov, A Spiridonov, A Stepennov, M Toms, E Vlasov, A Zhokin, T Aushev, A Bylinkin, R Chistov, M Danilov, P Parygin, D Philippov, S Polikarpov, E Tarkovskii, E Zhemchugov, V Andreev, M Azarkin, I Dremin, M Kirakosyan, A Terkulov, A Baskakov, A Belyaev, E Boos, A 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Sulak, D Zou, G Benelli, D Cutts, A Garabedian, J Hakala, U Heintz, J M Hogan, K H M Kwok, E Laird, G Landsberg, Z Mao, M Narain, S Piperov, S Sagir, R Syarif, D Yu, R Band, C Brainerd, D Burns, M Calderon De La Barca Sanchez, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, M Gardner, W Ko, R Lander, C Mclean, M Mulhearn, D Pellett, J Pilot, S Shalhout, M Shi, J Smith, D Stolp, K Tos, M Tripathi, Z Wang, M Bachtis, C Bravo, R Cousins, A Dasgupta, A Florent, J Hauser, M Ignatenko, N Mccoll, S Regnard, D Saltzberg, C Schnaible, V Valuev, E Bouvier, K Burt, R Clare, J Ellison, J W Gary, S M A Ghiasi Shirazi, G Hanson, J Heilman, P Jandir, E Kennedy, F Lacroix, O R Long, M Olmedo Negrete, M I Paneva, A Shrinivas, W Si, L Wang, H Wei, S Wimpenny, B R Yates, J G Branson, S Cittolin, M Derdzinski, B Hashemi, A Holzner, D Klein, G Kole, V Krutelyov, J Letts, I Macneill, M Masciovecchio, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, N Amin, R Bhandari, J Bradmiller-Feld, C Campagnari, A Dishaw, V Dutta, M Franco Sevilla, C George, F Golf, L Gouskos, J Gran, R Heller, J Incandela, S D Mullin, A Ovcharova, H Qu, J Richman, D Stuart, I Suarez, J Yoo, D Anderson, J Bendavid, A Bornheim, J M Lawhorn, H B Newman, T Nguyen, C Pena, M Spiropulu, J R Vlimant, S Xie, Z Zhang, R Y Zhu, M B Andrews, T Ferguson, T Mudholkar, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, M Weinberg, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, S Leontsinis, T Mulholland, K Stenson, S R Wagner, J Alexander, J Chaves, J Chu, S Dittmer, K Mcdermott, N Mirman, J R Patterson, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, S Abdullin, M Albrow, G Apollinari, A Apresyan, A Apyan, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, A Canepa, G B Cerati, H W K Cheung, F Chlebana, M Cremonesi, J Duarte, V D Elvira, J Freeman, Z Gecse, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, B Kreis, S Lammel, D Lincoln, R Lipton, M Liu, T Liu, R Lopes De Sá, J Lykken, K Maeshima, N Magini, J M Marraffino, S Maruyama, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, B Schneider, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, A Carnes, M Carver, D Curry, R D Field, I K Furic, J Konigsberg, A Korytov, K Kotov, P Ma, K Matchev, H Mei, G Mitselmakher, D Rank, D Sperka, N Terentyev, L Thomas, J Wang, S Wang, J Yelton, Y R Joshi, S Linn, P Markowitz, J L Rodriguez, A Ackert, T Adams, A Askew, S Hagopian, V Hagopian, K F Johnson, T Kolberg, G Martinez, T Perry, H Prosper, A Saha, A Santra, V Sharma, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, R Cavanaugh, X Chen, O Evdokimov, C E Gerber, D A Hangal, D J Hofman, K Jung, J Kamin, I D Sandoval Gonzalez, M B Tonjes, H Trauger, N Varelas, H Wang, Z Wu, J Zhang, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, J Roskes, U Sarica, M Swartz, M Xiao, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, J Castle, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, C Royon, S Sanders, E Schmitz, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, S Toda, F Rebassoo, D Wright, C Anelli, A Baden, O Baron, A Belloni, B Calvert, S C Eno, C Ferraioli, N J Hadley, S Jabeen, G Y Jeng, R G Kellogg, J Kunkle, A C Mignerey, F Ricci-Tam, Y H Shin, A Skuja, S C Tonwar, D Abercrombie, B Allen, V Azzolini, R Barbieri, A Baty, R Bi, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, G Gomez Ceballos, M Goncharov, D Hsu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, Y S Lai, Y-J Lee, A Levin, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Tatar, D Velicanu, J Wang, T W Wang, B Wyslouch, A C Benvenuti, R M Chatterjee, A Evans, P Hansen, S Kalafut, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, K Bloom, D R Claes, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, J Monroy, J E Siado, G R Snow, B Stieger, M Alyari, J Dolen, A Godshalk, C Harrington, I Iashvili, D Nguyen, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, D Wood, S Bhattacharya, O Charaf, K A Hahn, N Mucia, N Odell, B Pollack, M H Schmitt, K Sung, M Trovato, M Velasco, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, N Loukas, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, G Smith, S Taroni, M Wayne, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, W Ji, B Liu, W Luo, D Puigh, B L Winer, H W Wulsin, S Cooperstein, O Driga, P Elmer, J Hardenbrook, P Hebda, S Higginbotham, D Lange, J Luo, D Marlow, K Mei, I Ojalvo, J Olsen, C Palmer, P Piroué, D Stickland, C Tully, S Malik, S Norberg, A Barker, V E Barnes, S Das, S Folgueras, L Gutay, M K Jha, M Jones, A W Jung, A Khatiwada, D H Miller, N Neumeister, C C Peng, J F Schulte, J Sun, F Wang, W Xie, T Cheng, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, J Roberts, J Rorie, Z Tu, J Zabel, A Bodek, P de Barbaro, R Demina, Y T Duh, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, R Ciesielski, K Goulianos, C Mesropian, A Agapitos, J P Chou, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, R Montalvo, K Nash, M Osherson, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, M Foerster, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Castaneda Hernandez, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, T Kamon, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, J Damgov, F De Guio, P R Dudero, J Faulkner, E Gurpinar, S Kunori, K Lamichhane, S W Lee, T Libeiro, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, K Padeken, P Sheldon, S Tuo, J Velkovska, Q Xu, P Barria, B Cox, R Hirosky, M Joyce, A Ledovskoy, H Li, C Neu, T Sinthuprasith, Y Wang, E Wolfe, F Xia, R Harr, P E Karchin, J Sturdy, S Zaleski, M Brodski, J Buchanan, C Caillol, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, U Hussain, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, G A Pierro, G Polese, T Ruggles, A Savin, N Smith, W H Smith, D Taylor, N Woods
The azimuthal anisotropy Fourier coefficients (v_{n}) in 8.16 TeV p+Pb data are extracted via long-range two-particle correlations as a function of the event multiplicity and compared to corresponding results in pp and PbPb collisions. Using a four-particle cumulant technique, v_{n} correlations are measured for the first time in pp and p+Pb collisions. The v_{2} and v_{4} coefficients are found to be positively correlated in all collision systems. For high-multiplicity p+Pb collisions, an anticorrelation of v_{2} and v_{3} is observed, with a similar correlation strength as in PbPb data at the same multiplicity...
March 2, 2018: Physical Review Letters
Delphine Lumbroso, Soaad Soboh, Avi Maimon, Sagie Schif-Zuck, Amiram Ariel, Tal Burstyn-Cohen
The complete resolution of inflammation requires the uptake of apoptotic polymorphonuclear cells (PMN) by local macrophages (efferocytosis) and the consequent reprogramming of the engulfing phagocytes to reparative and pro-resolving phenotypes. The tyrosine kinase receptors TYRO3, AXL, and MERTK (collectively named TAM) are fundamental mediators in regulating inflammatory responses and efferocytosis. Protein S (PROS1) is a ligand for all TAM receptors that mediates various aspects of their activity. However, the involvement of PROS1 in the resolution of inflammation is incompletely understood...
2018: Frontiers in Immunology
Ja Hye Myung, Michael J Eblan, Joseph M Caster, Sinjung Park, Michael J Poellmann, Kyle Wang, Joel E Tepper, Kevin A Tam, Seth M Miller, Colette Shen, Ronald C Chen, Tian Zhang, Bhishamjit Chera, Andrew Z Wang, Seungpyo Hong
PURPOSE: We aimed to examine the effects of multivalent binding and biomimetic cell rolling on the sensitivity and specificity of circulating tumor cell (CTC) capture. We also investigated the clinical significance of CTCs and their kinetic profiles in cancer patients undergoing radiotherapy (RT) treatment. EXPERIMENTAL DESIGN: Patients with histologically confirmed primary carcinoma undergoing RT, with or without chemotherapy, were eligible for enrollment. Peripheral blood was collected prospectively at up to 5 time points, including prior to RT, at the first week, mid-point and final week of treatment, as well as 4 to 12 weeks after completion of RT...
March 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Liam Chung, Erik Thiele Orberg, Abby L Geis, June L Chan, Kai Fu, Christina E DeStefano Shields, Christine M Dejea, Payam Fathi, Jie Chen, Benjamin B Finard, Ada J Tam, Florencia McAllister, Hongni Fan, Xinqun Wu, Sudipto Ganguly, Andriana Lebid, Paul Metz, Sara W Van Meerbeke, David L Huso, Elizabeth C Wick, Drew M Pardoll, Fengyi Wan, Shaoguang Wu, Cynthia L Sears, Franck Housseau
No abstract text is available yet for this article.
March 14, 2018: Cell Host & Microbe
Farah Averill, Thomas G Brown, Robyn D Robertson, Angeline Tchomgang, Djamal Berbiche, Louise Nadeau, Marie Claude Ouimet
OBJECTIVES: In a pilot randomised controlled trial of contingency management (CM) and transdermal alcohol monitoring (TAM) with driving while impaired by alcohol (DWI) offenders, perceptions regarding the acceptability of a TAM device, recruitment issues, and the impact of CM and TAM on alcohol use over a six-week period were evaluated. The results aimed to inform the design of future trials and programs involving CM and TAM for DWI remediation. METHODS: TAM devices were affixed to 37 voluntary, community-recruited male DWI offenders with problem alcohol use...
March 15, 2018: Traffic Injury Prevention
Judit Karacsonyi, Ehrin J Armstrong, Huu Tam D Truong, Ryan Tsuda, Damianos G Kokkinidis, Jose Roberto Martinez-Parachini, Aya J Alame, Barbara A Danek, Aris Karatasakis, Michele Roesle, Houman Khalili, Imre Ungi, Subhash Banerjee, Emmanouil S Brilakis, Bavana V Rangan
BACKGROUND: The contemporary use and outcomes of excimer laser coronary atherectomy (ELCA) in percutaneous coronary intervention (PCI) are not well described. METHODS: We examined the baseline clinical and angiographic characteristics and procedural outcomes of 130 target lesions in 121 consecutive PCIs (n = 116 patients) in which ELCA was performed at three United States Department of Veterans Affairs (VA) medical centers between 2008 and 2016. RESULTS: Mean age was 68...
March 15, 2018: Journal of Invasive Cardiology
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