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https://www.readbyqxmd.com/read/29155225/a-systematic-review-of-the-long-term-effectiveness-of-work-based-lifestyle-interventions-to-tackle-overweight-and-obesity
#1
REVIEW
Greta Tam, May P S Yeung
Obesity is one of the five leading global risks for mortality, accounting for 5% of deaths worldwide. Workplace health promotion programs have the potential to deliver population-level interventions combining physical activity and exercise. However, there is no recent critical review of trials on long-term effectiveness of multicomponent lifestyle interventions in the workplace targeting obesity. Good quality evidence is needed to develop optimal strategies to tackle adult obesity. 1035 studies were retrieved by literature search in MEDLINE, Embase, PSYCH INFO and Cochrane library from 2005 to September 2016...
November 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29154050/decreased-use-of-pesticides-for-increased-yields-of-rice-and-fish-options-for-sustainable-food-production-in-the-mekong-delta
#2
Håkan Berg, Nguyen Thanh Tam
This study assesses the use of pesticides and the attitude to pest management strategies among rice and rice-fish farmers in the Can Tho and Tien Giang provinces in Vietnam. Interviews were made with 80 farmers. The farmers were divided in to farmers cultivating only rice with a high use (RHP) and low use (RLP) of pesticides, and farmers cultivating rice and fish with a high use (RFHP) and low use (RFLP) of pesticides. 80% of the HP farmers relied mainly on pesticides to control pests, while >80% of the LP farmers also applied IPM strategies...
November 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29153769/serum-sodium-response-to-hypertonic-saline-infusion-therapy-in-traumatic-brain-injury
#3
Scott A Chapman, Eric D Irwin, Matthew Thunselle, Alicia Ronk, Patty Reicks, Barb Curran, Krishna Rangarajan, Harrison Tam, Greg J Beilman
No abstract text is available yet for this article.
November 16, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29153327/auditory-sensitivity-and-decision-criteria-oscillate-at-different-frequencies-separately-for-the-two-ears
#4
Hao Tam Ho, Johahn Leung, David C Burr, David Alais, Maria Concetta Morrone
Many behavioral measures of visual perception fluctuate continually in a rhythmic manner, reflecting the influence of endogenous brain oscillations, particularly theta (∼4-7 Hz) and alpha (∼8-12 Hz) rhythms [1-3]. However, it is unclear whether these oscillations are unique to vision or whether auditory performance also oscillates [4, 5]. Several studies report no oscillatory modulation in audition [6, 7], while those with positive findings suffer from confounds relating to neural entrainment [8-10]. Here, we used a bilateral pitch-identification task to investigate rhythmic fluctuations in auditory performance separately for the two ears and applied signal detection theory (SDT) to test for oscillations of both sensitivity and criterion (changes in decision boundary) [11, 12]...
November 10, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29152078/cd163-as-a-novel-target-gene-of-stat3-is-a-potential-therapeutic-target-for-gastric-cancer
#5
Zhenguo Cheng, Danhua Zhang, Baocheng Gong, Pengliang Wang, Funan Liu
CD163 is a member of the scavenger receptor cysteine-rich superfamily, and has been widely used to identify M2 type macrophage. However, the expression of CD163 in gastric cancer and its regulatory mechanism are still unclear. Here we show that CD163 is elevated in gastric cancer tissues. High expression of CD163 is a potential indicator to evaluate the status of tumor associated macrophages (TAMs), regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs) and cancer associated fibroblasts (Cafs)...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151975/clinical-significance-of-cd163-and-cd68-tumor-associated-macrophages-in-high-risk-hpv-related-cervical-cancer
#6
Xiao-Jing Chen, Ling-Fei Han, Xiang-Guang Wu, Wen-Fei Wei, Lan-Fang Wu, Hong-Yan Yi, Rui-Ming Yan, Xiang-Yang Bai, Mei Zhong, Yan-Hong Yu, Li Liang, Wei Wang
Objective. To explore the influence of M2-polarized tumor-associated macrophages (TAMs) on high-risk human papillomavirus (hr-HPV)-related cervical carcinogenesis and metastasis. Methods. CD68+ and CD163+ macrophages were examined immunohistochemically in a series of 130 samples, including 26 cases of normal cervical tissues, 59 cases of cervical intraepithelial neoplasia (CIN), and 45 cases of squamous cell carcinoma (SCC), and the results were statistically analyzed. The macrophage count was corrected for the epithelial and stromal compartments respectively...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151937/combination-of-plasma-ha-and-circulating-m2-like-monocytes-may-serve-as-a-diagnostic-marker-for-breast-cancer
#7
Boke Zhang, Manlin Cao, Yiqing He, Yiwen Liu, Guoliang Zhang, Cuixia Yang, Yan Du, Jing Xu, Jiajie Hu, Feng Gao
Background: Breast cancer (BC)-derived hyaluronan (HA) can induce the formation of M2-like tumor-associated macrophages (TAMs) in tumor context. However, little is known about the correlation between circulating M2-like monocytes and plasma HA in BC patients. This study focused on evaluating the relationship between circulating M2-like monocytes and plasma HA, and further appraised the diagnostic value of them in BC. Methods: The expression of M2-like TAMs and HA was determined in pathological tissues by immunohistochemistry...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151397/-i-can-t-do-this-alone-a-study-on-foreign-domestic-workers-providing-long-term-care-for-frail-seniors-at-home
#8
Wai Jia Tam, Gerald Choon-Huat Koh, Helena Legido-Quigley, Ngoc Huong Lien Ha, Philip Lin Kiat Yap
BACKGROUND: Foreign domestic workers (FDWs) play an important role in long-term caregiving of seniors at home. However, how FDWs cope with the caregiving demands, the dynamic interaction between familial and FDW caregivers and its impact on care recipients remain largely un-explored. Existing caregiver interventions mainly target familial caregivers; little assistance is available for FDW caregivers. This study explores FDWs' challenges, coping strategies, and the support they need in caring for seniors...
November 20, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29150635/one-pot-synthesis-of-trifunctional-chitosan-edta-%C3%AE-cyclodextrin-polymer-for-simultaneous-removal-of-metals-and-organic-micropollutants
#9
Feiping Zhao, Eveliina Repo, Dulin Yin, Li Chen, Simo Kalliola, Juntao Tang, Evgenia Iakovleva, Kam Chiu Tam, Mika Sillanpää
The global contamination of water resources with inorganic and organic micropollutants, such as metals and pharmaceuticals, poses a critical threat to the environment and human health. Herein, we report on a bio-derived chitosan-EDTA-β-cyclodextrin (CS-ED-CD) trifunctional adsorbent fabricated via a facile and green one-pot synthesis method using EDTA as a cross-linker, for the adsorption of toxic metals and organic micropollutants from wastewater. In this system, chitosan chain is considered as the backbone, and the immobilized cyclodextrin cavities capture the organic compounds via host-guest inclusion complexation, while EDTA-groups complex metals...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150611/uplift-of-the-central-transantarctic-mountains
#10
Phil Wannamaker, Graham Hill, John Stodt, Virginie Maris, Yasuo Ogawa, Kate Selway, Goran Boren, Edward Bertrand, Daniel Uhlmann, Bridget Ayling, A Marie Green, Daniel Feucht
The Transantarctic Mountains (TAM) are the world's longest rift shoulder but the source of their high elevation is enigmatic. To discriminate the importance of mechanical vs. thermal sources of support, a 550 km-long transect of magnetotelluric geophysical soundings spanning the central TAM was acquired. These data reveal a lithosphere of high electrical resistivity to at least 150 km depth, implying a cold stable state well into the upper mantle. Here we find that the central TAM most likely are elevated by a non-thermal, flexural cantilever mechanism which is perhaps the most clearly expressed example anywhere...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29148078/soluble-tam-receptor-tyrosine-kinases-in-rheumatoid-arthritis-correlation-with-disease-activity-and-bone-destruction
#11
Liling Xu, Fanlei Hu, Huaqun Zhu, Xu Liu, Lianjie Shi, Yun Li, Hua Zhong, Su Yin
The TAM receptor tyrosine kinases (TAM RTK) are a subfamily of receptor tyrosine kinases, the role of which in autoimmune diseases such as systemic lupus erythematosus has been well-explored, while their functions in rheumatoid arthritis (RA) remain largely unknown. In this study, we investigated the role of soluble TAM receptor tyrosine kinases (sAxl/sMer/sTyro3) in the patients with RA. 306 RA patients, 100 osteoarthritis (OA) patients and 120 healthy controls (HCs) were enrolled in this study. The serum concentrations of sAxl/sMer/sTyro3 were measured by ELISA, then the associations between sAxl/sMer/sTyro3 levels and clinical features of RA patients were analyzed...
November 17, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29143618/using-the-missed-opportunity-tool-as-an-application-of-the-lives-saved-tool-list-for-intervention-prioritization
#12
Yvonne Tam, Luwei Pearson
BACKGROUND: The Missed Opportunity tool was developed as an application in the Lives Saved Tool (LiST) to allow users to quickly compare the relative impact of interventions. Global Financing Facility (GFF) investment cases have been identified as a potential application of the Missed Opportunity analyses in Democratic Republic of the Congo (DRC), Ethiopia, Kenya, and Tanzania, to use 'lives saved' as a normative factor to set priorities. METHODS: The Missed Opportunity analysis draws on data and methods in LiST to project maternal, stillbirth, and child deaths averted based on changes in interventions' coverage...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29142959/hemodialysis-infection-prevention-protocols-ontario-shower-technique-hippo-st-a-pilot-randomized-trial
#13
S Daisy Kosa, Amiram Gafni, Andrew A House, JulieAnn Lawrence, Louise Moist, Bharat Nathoo, Paul Tam, Alicia Sarabia, Lehana Thabane, George Wu, Charmaine E Lok
Introduction: We developed the Hemodialysis Infection Prevention Protocols Ontario-Shower Technique (HIPPO-ST) to permit hemodialysis (HD) patients with central venous catheters (catheters) to shower without additional infection risk. Our primary objective was to determine the feasibility of conducting a parallel randomized controlled trial (RCT) to evaluate the impact of HIPPO-ST on catheter-related bacteremia (CRB) in adult HD patients. Methods: Adult HD patients using catheters were recruited from 11 HD units...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29142805/role-of-adjuvant-treatment-in-sinonasal-mucosal-melanoma
#14
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
Purpose  Sinonasal mucosal melanoma (SNMM) is a locally aggressive tumor. This study aimed to define the role of adjuvant treatment and its association with survival outcomes of SNMM. Methods  This retrospective study investigated 152 patients with SNMM treated between 1991 and 2016 in MD Anderson Cancer Center. Patients were divided into the following treatment groups: surgery alone, surgery with postoperative radiotherapy (PORT), surgery with postoperative chemoradiation (POCRT), and induction chemotherapy followed by surgery and PORT...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29142426/in-silico-and-in-vitro-anticancer-activity-of-isolated-novel-marker-compound-from-chemically-modified-bioactive-fraction-from-curcuma-longa-nccl
#15
Arshi Naqvi, Richa Malasoni, Swati Gupta, Akansha Srivastava, Rishi R Pandey, Anil Kumar Dwivedi
Background: Turmeric (Curcuma longa) is reported to possess wide array of biological activities. Herbal Medicament (HM) is a standardized hexane-soluble fraction of C. longa and is well known for its neuroprotective effect. Objective: In this study, we attempted to synthesize a novel chemically modified bioactive fraction from HM (NCCL) along with isolation and characterization of a novel marker compound (I). Materials and Methods: NCCL was prepared from HM...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142311/a-standardized-herbal-extract-mitigates-tumor-inflammation-and-augments-chemotherapy-effect-of-docetaxel-in-prostate-cancer
#16
Chin-Hsien Tsai, Sheue-Fen Tzeng, Shih-Chuan Hsieh, Yu-Chih Yang, Yi-Wen Hsiao, Mong-Hsun Tsai, Pei-Wen Hsiao
Activation of the NFκB pathway is often associated with advanced cancer and has thus been regarded as a rational therapeutic target. Wedelia chinensis is rich in luteolin, apigenin, and wedelolactone that act synergistically to suppress androgen receptor activity in prostate cancer. Interestingly, our evaluation of a standardized Wedelia chinensis herbal extract (WCE) concluded its efficacy on hormone-refractory prostate cancer through systemic mechanisms. Oral administration of WCE significantly attenuated tumor growth and metastasis in orthotopic PC-3 and DU145 xenografts...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142104/constraints-on-lateral-gene-transfer-in-promoting-fimbrial-usher-protein-diversity-and-function
#17
Christopher J Stubenrauch, Gordon Dougan, Trevor Lithgow, Eva Heinz
Fimbriae are long, adhesive structures widespread throughout members of the family Enterobacteriaceae. They are multimeric extrusions, which are moved out of the bacterial cell through an integral outer membrane protein called usher. The complex folding mechanics of the usher protein were recently revealed to be catalysed by the membrane-embedded translocation and assembly module (TAM). Here, we examine the diversity of usher proteins across a wide range of extraintestinal (ExPEC) and enteropathogenic (EPEC) Escherichia coli, and further focus on a so far undescribed chaperone-usher system, with this usher referred to as UshC...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29142027/underestimation-of-risk-of-carotid-subclinical-atherosclerosis-by-cardiovascular-risk-scores-in-patients-with-psoriatic-arthritis
#18
Jiayun Shen, Steven H Lam, Qing Shang, Chun-Kwok Wong, Edmund K Li, Priscilla Wong, Emily W Kun, Isaac T Cheng, Martin Li, Tena K Li, Tracy Y Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
OBJECTIVE: To test the performances of established cardiovascular (CV) risk scores in discriminating subclinical atherosclerosis (SCA) in patients with psoriatic arthritis. METHODS: These scores were calculated: Framingham risk score (FRS), QRISK2, Systematic COronary Risk Evaluation (SCORE), 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD) from the American College of Cardiology and the American Heart Association, and the European League Against Rheumatism (EULAR)-recommended modified versions (by 1...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29141914/proteotranscriptomics-reveal-signaling-networks-in-the-ovarian-cancer-microenvironment
#19
Thomas Worzfeld, Florian Finkernagel, Silke Reinartz, Anne Konzer, Till Adhikary, Andrea Nist, Thorsten Stiewe, Uwe Wagner, Mario Looso, Johannes Graumann, Rolf Müller
Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal fluid, where tumor cell spheroids (TU), tumor-associated T cells (TAT), and macrophages (TAM) create a unique microenvironment promoting cancer progression, chemoresistance and immuno-suppression. However, the underlying signaling mechanisms remain largely obscure.  To chart these signaling networks, we performed comprehensive proteomic and transcriptomic analyses of TU, TAT and TAM from ascites of ovarian cancer patients...
November 15, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29140516/effectiveness-of-masks-and-respirators-against-respiratory-infections-in-healthcare-workers-a-systematic-review-and-meta-analysis
#20
Vittoria Offeddu, Chee Fu Yung, Mabel Sheau Fong Low, Clarence C Tam
This systematic review and meta-analysis quantified the protective effect of facemasks and respirators against respiratory infections among healthcare workers. Relevant articles were retrieved from Pubmed, EMBASE, and Web of Science. Meta-analyses were conducted to calculate pooled estimates. Meta-analysis of randomized controlled trials (RCTs) indicated a protective effect of masks and respirators against clinical respiratory illness (CRI) (risk ratio [RR] = 0.59; 95% confidence interval [CI]:0.46-0.77) and influenza-like illness (ILI) (RR = 0...
November 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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