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Calcium metabolism

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https://www.readbyqxmd.com/read/29333468/extraosseous-accumulation-of-technetium-99m-methyl-diphosphonate-99mtc-mdp-in-a-child-with-all-a-case-report
#1
Farnaz Banezhad, Narjess Ayati, Farrokh Seilanian Toosi, Samine Boloursaz, S Rasoul Zakavi
Extraosseous accumulation of technetium-99m-methyl diphosphonate (99mTc-MDP) on bone scan is not common. This phenomenon is often attributed to abnormality of calcium metabolism and has been reported in a variety of conditions including metabolic diseases and malignancies. A five years old boy is presented here, who was admitted to the pediatric emergency suffering from fatigue, respiratory symptoms, weight loss, intermittent fevers, anorexia, nausea and vomiting, edema of legs and abdominal distension for one month...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/29332191/genome-wide-characterization-of-differentially-expressed-genes-provides-insights-into-regulatory-network-of-heat-stress-response-in-radish-raphanus-sativus-l
#2
Ronghua Wang, Yi Mei, Liang Xu, Xianwen Zhu, Yan Wang, Jun Guo, Liwang Liu
Heat stress (HS) causes detrimental effects on plant morphology, physiology, and biochemistry that lead to drastic reduction in plant biomass production and economic yield worldwide. To date, little is known about HS-responsive genes involved in thermotolerance mechanism in radish. In this study, a total of 6600 differentially expressed genes (DEGs) from the control and Heat24 cDNA libraries of radish were isolated by high-throughput sequencing. With Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, some genes including MAPK, DREB, ERF, AP2, GST, Hsf, and Hsp were predominantly assigned in signal transductions, metabolic pathways, and biosynthesis and abiotic stress-responsive pathways...
January 13, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29330662/yogurt-consumption-is-associated-with-higher-nutrient-intake-diet-quality-and-favourable-metabolic-profile-in-children-a-cross-sectional-analysis-using-data-from-years-1-4-of-the-national-diet-and-nutrition-survey-uk
#3
D A Hobbs, D I Givens, J A Lovegrove
PURPOSE: Yogurt consumption has been associated with higher nutrient intakes, better diet quality and improved metabolic profiles in adults. Few studies have investigated these associations in children. This study investigated the association of yogurt consumption with nutrient intakes, diet quality and metabolic profile in British children. METHODS: Data from  1687 children aged 4-10 and 11-18 years of the National Diet and Nutrition Survey (NDNS) years 1-4 were analysed...
January 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29326306/weekly-standard-kt-vurea-and-clinical-outcomes-in-home-and-in-center-hemodialysis
#4
Matthew B Rivara, Vanessa Ravel, Elani Streja, Yoshitsugu Obi, Melissa Soohoo, Alfred K Cheung, Jonathan Himmelfarb, Kamyar Kalantar-Zadeh, Rajnish Mehrotra
BACKGROUND AND OBJECTIVES: Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used multivariable regression to examine the association of dialysis standard Kt/Vurea with BP and metabolic control (serum potassium, calcium, bicarbonate, and phosphorus) in patients incidental to dialysis treated with home (n=2373) or in-center hemodialysis (n=109,273)...
January 11, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29323106/sequential-forward-and-reverse-transport-of-the-na-ca2-exchanger-generates-ca2-oscillations-within-mitochondria
#5
Krishna Samanta, Gary R Mirams, Anant B Parekh
Mitochondrial Ca2+ homoeostasis regulates aerobic metabolism and cell survival. Ca2+ flux into mitochondria is mediated by the mitochondrial calcium uniporter (MCU) channel whereas Ca2+ export is often through an electrogenic Na+-Ca2+ exchanger. Here, we report remarkable functional versatility in mitochondrial Na+-Ca2+ exchange under conditions where mitochondria are depolarised. Following physiological stimulation of cell-surface receptors, mitochondrial Na+-Ca2+ exchange initially operates in reverse mode, transporting cytosolic Ca2+ into the matrix...
January 11, 2018: Nature Communications
https://www.readbyqxmd.com/read/29322864/effects-of-danshen-tablets-on-pharmacokinetics-of-atorvastatin-calcium-in-rats-and-its-potential-mechanism
#6
Sen Sun, Rong Wang, Jie Fan, Guoqing Zhang, Hai Zhang
CONTEXT: Danshen tablets (DST), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in the clinic. OBJECTIVE: This study investigated the effects of DST on the pharmacokinetics of AC and the potential mechanism. MATERIALS AND METHODS: The pharmacokinetics of AC (1 mg/kg) with or without pretreatment of DST (100 mg/kg) were investigated using LC-MS/MS...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29322073/high-fat-high-sucrose-diet-results-in-higher-bone-mass-in-aged-rats
#7
Akira Minematsu, Yasue Nishii, Susumu Sakata
Intake of high-fat/high-sucrose (HFS) diet or high fat diet influences bone metabolism in young rodents, but its effects on bone properties of aged rodents still remain unclear. This study aimed to examine the effects of HFS diet intake on trabecular bone architecture (TBA) and cortical bone geometry (CBG) in aged rats. Fifteen male Wistar rats over 1 year were randomly divided into two groups. One group was fed a standard laboratory diet (SLD) and the other group was fed a HFS diet for six months. The femur/tibia, obtained from both groups at the end of experimental period, were scanned by micro-computed tomography for TBA/CBG analyses...
June 2018: Bone Reports
https://www.readbyqxmd.com/read/29322026/the-pgris-and-parathyroid-splinting-concepts-for-the-analysis-and-prognosis-of-protracted-hypoparathyroidism
#8
Antonio Sitges-Serra
Most patients with hypocalcemia after total thyroidectomy will recover the parathyroid function in a few weeks, but some 20-30% of them will still be in the need for replacement therapy one month after surgery and about 5-10% of those will develop permanent hypoparathyroidism. Although postoperative hypocalcemia has been related to several demographic and metabolic causes, parathyroid hormone (PTH) decline, resulting from autotransplantation, inadvertent excision or devascularization of the parathyroid glands, is the common final pathway...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29321498/the-ppi-network-analysis-of-mrna-expression-profile-of-uterus-from-primary-dysmenorrheal-rats
#9
Pei Fan, Qiao-Hui Lin, Ying Guo, Lan-Ling Zhao, He Ning, Meng-Ying Liu, Dong-Qing Wei
To elucidate the mechanisms of molecular regulations underlying primary dysmenorrhea (PD), we used our previously published mRNA expression profile of uterus from PD syndrome rats to construct protein-protein interactions (PPI) network via STRING Interactome. Consequently, 34 subnetworks, including a "continent" (Subnetwork 1) and 33 "islands" (Subnetwork 2-34) were generated. The nodes, with relative expression ratios, were visualized in the PPI networks and their connections were identified. Through path and module exploring in the network, the bridges were found from pathways of cellular response to calcium ion, SMAD protein signal transduction, regulation of transcription from RNA polymerase II promoter in response to stress and muscle stretch that were significantly enriched by the up-regulated mRNAs, to the cascades of cAMP metabolic processes and positive regulation of cyclase activities by the down-regulated ones...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320712/serca2b-cycles-its-way-to-ucp1-independent-thermogenesis-in-beige-fat
#10
Emilio P Mottillo, Vanesa D Ramseyer, James G Granneman
A new study in Nature Medicine, by Ikeda et al. (2017), reports that calcium cycling in beige adipocytes elevates energy expenditure and glucose oxidation in the absence of uncoupling protein 1. Thermogenic calcium cycling in beige fat is mediated by SERCA2b and improves cold tolerance and metabolic status.
January 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29319775/primary-hiperoxaluria-diagnosed-after-kidney-transplantation-report-of-2-cases-and-literature-review
#11
John Fredy Nieto Rios, Monica Zuluaga, Lina Maria Serna Higuita, Adriana Florez, Diana Carolina Bello-Marquez, Arbey Aristizábal, Catalina Ocampo Kohn, Gustavo Adolfo Zuluaga
Primary hyperoxaluria (PH) is a very rare genetic disorder; it is characterized by total or partial deficiency of the enzymes related to the metabolism of glyoxylate, with an overproduction of calcium oxalate that is deposited in different organs, mainly the kidney, leading to recurrent lithiasis, nephrocalcinosis and end stage renal disease (ESRD). In patients with ESRD that receive kidney transplantation alone, the disease has a relapse of 100%, with graft loss in a high percentage of patients in the first 5 years of transplantation...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29317521/ca2-dependent-demethylation-of-phosphatase-pp2ac-promotes-glucose-deprivation-induced-cell-death-independently-of-inhibiting-glycolysis
#12
Ha Yin Lee, Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H Shawn Je, Egon Ogris, David M Virshup, Koji Itahana
Cancer cells increase glucose metabolism to support aerobic glycolysis. However, only some cancer cells are acutely sensitive to glucose withdrawal, and the underlying mechanism of this selective sensitivity is unclear. We showed that glucose deprivation initiates a cell death pathway in cancer cells that is dependent on the kinase RIPK1. Glucose withdrawal triggered rapid plasma membrane depolarization and an influx of extracellular calcium into the cell through the L-type calcium channel Cav1.3 (CACNA1D), followed by activation of the kinase CAMK1...
January 9, 2018: Science Signaling
https://www.readbyqxmd.com/read/29316405/magnesium-zinc-calcium-vitamin-d-co-supplementation-improves-glycemic-control-and-markers-of-cardio-metabolic-risk-in-gestational-diabetes-a-randomized-double-blind-placebo-controlled-trial
#13
Maryam Karamali, Shahla Bahramimoghadam, Fateme Sharifzadeh, Zatollah Asemi
To the best our knowledge, data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk in gestational diabetes mellitus (GDM) are scarce. The purpose of this study was to establish the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardio-metabolic risk of GDM patients. Sixty patients with GDM, aged 18-40 years old were randomised into two groups to intake either magnesium-zinc-calcium-vitamin D co-supplements or placebo (n=30 each group) for 6 weeks in a randomized, double-blind, placebo-controlled trial...
January 9, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29316238/composite-porous-scaffold-of-polyethylene-glycol-peg-polylactic-acid-pla-support-improved-bone-matrix-deposition-in-vitro-compared-to-pla-only-scaffolds
#14
Birru Bhaskar, Robert Owen, Hossein Bahmaee, Zena Wally, Parcha Sreenivasa Rao, Gwendolen C Reilly
Controllable pore size and architecture are essential properties for tissue-engineering scaffolds to support cell ingrowth colonization. To investigate the effect of PEG addition on porosity and bone-cell behavior, porous Polylactic acid (PLA)-Polyethylene glycol (PEG) scaffolds were developed with varied weight ratios of PLA-PEG (100/0, 90/10, 75/25) using solvent casting and porogen leaching. Sugar 200-300 µm in size was used as a porogen. To assess their suitability for bone tissue engineering, MLO-A5 murine osteoblast cells were cultured and cell metabolic activity, alkaline phosphatase (ALP) activity and bone-matrix production determined (alizarin red S staining for calcium, direct red 80 staining for collagen)...
January 9, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29315312/taking-the-metabolic-pulse-of-the-world-s-coral-reefs
#15
Tyler Cyronak, Andreas J Andersson, Chris Langdon, Rebecca Albright, Nicholas R Bates, Ken Caldeira, Renee Carlton, Jorge E Corredor, Rob B Dunbar, Ian Enochs, Jonathan Erez, Bradley D Eyre, Jean-Pierre Gattuso, Dwight Gledhill, Hajime Kayanne, David I Kline, David A Koweek, Coulson Lantz, Boaz Lazar, Derek Manzello, Ashly McMahon, Melissa Meléndez, Heather N Page, Isaac R Santos, Kai G Schulz, Emily Shaw, Jacob Silverman, Atsushi Suzuki, Lida Teneva, Atsushi Watanabe, Shoji Yamamoto
Worldwide, coral reef ecosystems are experiencing increasing pressure from a variety of anthropogenic perturbations including ocean warming and acidification, increased sedimentation, eutrophication, and overfishing, which could shift reefs to a condition of net calcium carbonate (CaCO3) dissolution and erosion. Herein, we determine the net calcification potential and the relative balance of net organic carbon metabolism (net community production; NCP) and net inorganic carbon metabolism (net community calcification; NCC) within 23 coral reef locations across the globe...
2018: PloS One
https://www.readbyqxmd.com/read/29310935/degradation-of-brown-adipocyte-purine-nucleotides-regulates-uncoupling-protein-1-activity
#16
Tobias Fromme, Karin Kleigrewe, Andreas Dunkel, Angelika Retzler, Yongguo Li, Stefanie Maurer, Natascha Fischer, Rolf Diezko, Timo Kanzleiter, Verena Hirschberg, Thomas Hofmann, Martin Klingenspor
OBJECTIVE: Non-shivering thermogenesis in mammalian brown adipose tissue depends on thermogenic uncoupling protein 1. Its activity is triggered by free fatty acids while purine nucleotides mediate inhibition. During activation, it is thought that free fatty acids overcome purine-mediated inhibition. We measured the cellular concentration and the release of purine nucleotide metabolites to uncover a possible role of purine nucleotide degradation in uncoupling protein 1 activation. METHODS: With mass spectrometry, purine nucleotide metabolites were quantified in cellular homogenates and supernatants of cultured primary brown adipocytes...
December 26, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29309397/assessment-of-bone-mineral-density-in-patients-with-cirrhosis-treated-with-third-generation-nucleos-t-ide-analogues-comparison-between-tenofovir-and-entecavir
#17
Marta Tonon, Salvatore Piano, Antonietta Romano, Silvano Fasolato, Marialuisa Stanco, Chiara Pilutti, Patrizia Pontisso, Sara Mareso, Carmine Gambino, Leonardo Sartori, Paolo Angeli
BACKGROUND AND AIM: Tenofovir and entecavir are nowadays the first-line treatment in hepatitis B virus (HBV)-related cirrhosis. Both drugs were shown to be effective in HBV suppression and well tolerated. The effects of tenofovir on bone mineral density (BMD), however, were shown to worsen the rate of osteoporosis, which is already a common feature in cirrhosis. In contrast, entecavir seems to have no effect on mineral metabolism. The aim of our study was to compare the effects of nucleos(t)ide analogs on bone density in HBV-related cirrhosis...
January 5, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29307143/prediction-of-metal-ion-binding-sites-in-proteins-from-amino-acid-sequences-by-using-simplified-amino-acid-alphabets-and-random-forest-model
#18
Suresh Kumar
Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis. In structural genomics, prediction of metal binding proteins help in the selection of suitable growth medium for overexpression's studies and also help in obtaining the functional protein. Computational prediction using machine learning approach has been widely used in various fields of bioinformatics based on the fact all the information contains in amino acid sequence...
December 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/29305813/a-simultaneous-mixed-effects-pharmacokinetic-model-for-nefopam-n-desmethylnefopam-and-nefopam-n-oxide-in-human-plasma-and-urine
#19
Aravind Mittur
BACKGROUND AND OBJECTIVE: Nefopam is a non-opioid, non-steroidal, central analgesic thought to act via multiple mechanisms including potent inhibition of serotonin-norepinephrine reuptake and modulation of voltage-sensitive calcium and sodium channels. There has been a resurgence in its use for postoperative pain and neuropathic pain. Dosing route-dependent metabolism and clinical effects have been described following intravenous and oral nefopam. N-desmethylnefopam and nefopam N-oxide are metabolites of clinical interest...
January 5, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29304200/nitro-oxidative-metabolism-during-fruit-ripening
#20
Francisco J Corpas, Luciano Freschi, Marta Rodríguez-Ruiz, Paulo T Mioto, Salvador González-Gordo, José M Palma
Pepper (Capsicum annuum L.) and tomato (Solanum lycopersicum L.), which belong to the Solanaceae family, are among the most cultivated and consumed fleshy fruits worldwide and constitute excellent sources of many essential nutrients, such as vitamins A, C, and E, calcium, and carotenoids. While fruit ripening is a highly regulated and complex process, tomato and pepper have been classified as climacteric and non-climacteric fruits, respectively. These fruits differ greatly in shape, color composition, flavor, and several other features which undergo drastic changes during the ripening process...
January 3, 2018: Journal of Experimental Botany
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