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https://www.readbyqxmd.com/read/29909501/decreasing-rates-of-major-lower-extremity-amputation-in-people-with-diabetes-but-not-in-those-without-a-nationwide-study-in-belgium
#1
Heiner Claessen, Herve Avalosse, Joeri Guillaume, Maria Narres, Tatjana Kvitkina, Werner Arend, Stephan Morbach, Patrick Lauwers, Frank Nobels, Jacques Boly, Chris Van Hul, Kris Doggen, Isabelle Dumont, Patricia Felix, Kristien Van Acker, Andrea Icks
AIMS/HYPOTHESIS: The reduction of major lower-extremity amputations (LEAs) is one of the main goals in diabetes care. Our aim was to estimate annual LEA rates in individuals with and without diabetes in Belgium, and corresponding time trends. METHODS: Data for 2009-2013 were provided by the Belgian national health insurance funds, covering more than 99% of the Belgian population (about 11 million people). We estimated the age-sex standardised annual amputation rate (first per year) in the populations with and without diabetes for major and minor LEAs, and the corresponding relative risks...
June 16, 2018: Diabetologia
https://www.readbyqxmd.com/read/29909388/lymphedema-secondary-to-limited-cutaneous-systemic-sclerosis
#2
Sónia Moreira, Jorge Crespo, Lèlita Santos
Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by vascular abnormalities, immune system activation and fibrosis. Lymphatic involvement in SSc was described more recently and starts in early stages. This report describes a 46-year-old patient who developed over the last 2 years asymmetric lymphedema in lower extremities. Compromise in lymphatic drainage was confirmed by lymphoscintigraphy. She also presented Raynaud's phenomenon, a scleroderma pattern in nailfold capillaroscopy, cutaneous thickening and anticentromere antibodies, which together resulted in a new diagnosis of limited cutaneous SSc...
June 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29909232/load-distribution-on-the-foot-and-lofstrand-crutches-of-amputee-football-players
#3
Yasar Tatar, Nejla Gercek, Nusret Ramazanoglu, Irfan Gulmez, Selda Uzun, Goktug Sanli, Cengiz Karagozoglu, Hasan Birol Cotuk
BACKGROUND: Amputee football is a worldwide popular sport with positive physical and psychological effects on the disabled. Amputee players use their hands dominantly for locomotion. However, the effect of using upper extremity which is not accommodated to loading is not very well known. RESEARCH QUESTION: The objective of this study was to determine the load distribution of amputee football players during walking, running and kicking the ball. METHODS: This study was conducted with 15 certified amputee football players (age 24...
June 9, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29909231/effects-of-unstable-shoes-on-trunk-muscle-activity-in-patients-with-chronic-low-back-pain
#4
P Salvador-Coloma, M D Arguisuelas, J Doménech-Fernández, D Sánchez-Zuriaga, J J Amer-Cuenca, J Martínez-Gramage, F J Montañez-Aguilera, J F Lisón
INTRODUCTION: Unstable shoes were developed as a walking device to strengthen the lower extremity muscles and reduce joint loading. Many studies have reported increased muscle activity throughout the gait cycle in most of the lower limb muscles in healthy adults using these shoes. However, no previous studies have explored the effects of wearing unstable shoes on trunk muscle activity in patients with chronic low back pain (CLBP). Therefore, the aim of the present study was to compare the activity of selected trunk muscles in patients with CLBP during a gait test while walking wearing unstable shoes or conventional flat shoes (control)...
June 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29907750/examining-the-associations-among-fibrocystic-breast-change-total-lean-mass-and-percent-body-fat
#5
Yuan-Yuei Chen, Wen-Hui Fang, Chung-Ching Wang, Tung-Wei Kao, Yaw-Wen Chang, Hui-Fang Yang, Chen-Jung Wu, Yu-Shan Sun, Wei-Liang Chen
Fibrocystic breast change (FBC) is extremely common and occurrs in 90% of women during their lives. The association between body composition and risk of breast cancer is well established. We hypothesized that the effect might exist during the development of FBC. Our aim was to examine the relationships of total lean mass (TLM) and percent body fat (PBF) with FBC in a general female population. In total, 8477 female subjects aged 20 years or older were enrolled in the study at the Tri-Service General Hospital in Taiwan from 2011 to 2016...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907516/repeatability-of-tibial-acceleration-measurements-made-on-children-during-walking-and-running
#6
Oren Tirosh, Guy Orland, Alon Eliakim, Dan Nemet, Nili Steinberg
OBJECTIVES: To determine the between-visit reliability of an accelerometer as a measure of lower-extremity impact acceleration at a variety of gait speeds in children. DESIGN: Absolute reliability assessment. METHODS: Ten children with no known gait pathology attended two testing sessions, three weeks apart. A tri-axial accelerometer was fixed to the child's distal tibia to measure peak positive acceleration responses while walking and running on the treadmill at three different speeds (comfortable walking, threshold walking, and jogging)...
June 5, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29906976/magnetic-quasi-long-range-ordering-in-nematic-systems-due-to-competition-between-higher-order-couplings
#7
Milan Žukovič, Georgii Kalagov
Critical properties of the two-dimensional XY model involving solely nematic-like terms of the second and third orders are investigated by spin-wave analysis and Monte Carlo simulation. It is found that, even though neither of the nematic-like terms alone can induce magnetic ordering, their coexistence and competition leads to an extended phase of the magnetic quasi-long-range-order phase, wedged between the two nematic-like phases induced by the respective couplings. Thus, except for the multicritical point, at which all the phases meet, for any finite value of the coupling parameters ratio there are two phase transition: one from the paramagnetic phase to one of the two nematic-like phases followed by another one at lower temperatures to the magnetic phase...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906811/comparison-of-hand-sewn-versus-coupled-venous-anastomoses-in-traumatic-lower-extremity-reconstruction
#8
John T Stranix, William J Rifkin, Z-Hye Lee, Lavinia Anzai, Adam Jacoby, Daniel J Ceradini, Vishal Thanik, Pierre B Saadeh, Jamie P Levine
BACKGROUND:  Microvascular reconstruction of the lower extremity has the highest reported complication and flap failure rates of any anatomical region. Despite widespread adoption of the mechanical anastomotic venous coupler and encouraging results in other anatomical regions, there are limited reports examining its use in the lower extremity. This study compares outcomes between coupled and hand-sewn venous anastomoses in traumatic lower extremity reconstruction. METHODS:  Retrospective review of our institutional flap registry from 1979 to 2016 identified soft tissue free flaps performed for the reconstruction of Gustilo type IIIB/IIIC open tibial fractures...
June 15, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29906562/amino-acid-conjugated-chitosan-nanoparticles-for-the-brain-targeting-of-a-model-dipeptidyl-peptidase-4-inhibitor
#9
Jessica Fernandes, M Vivek Ghate, Sanchari Basu Mallik, Shaila A Lewis
Saxagliptin (SAX) is dipeptidyl peptidase-4 enzyme inhibitor molecule now explored for its activity in the therapy of Alzheimer's disease. Being extremely hydrophilic, it is unable to permeate the blood-brain barrier by the conventional therapy modalities. Further repurposing the drug, SAX is associated with a reduction in the blood sugar level in the periphery. In the present study, the chitosan-L-valine conjugate was synthesized by carbodiimide chemistry. The conjugate was then used to prepare nanoparticles encapsulating SAX...
June 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29906470/the-effect-of-intracerebroventricular-allopregnanolone-on-depressive-like-behaviors-of-rats-selectively-bred-for-high-and-low-immobility-in-the-forced-swim-test
#10
Felipe Borges Almeida, Alan Rios Fonseca, Núbia Heidrich, Maurício Schüler Nin, Helena Maria Tannhauser Barros
Depression is a highly incapacitating disorder known to have a multifactorial etiology, including a hereditary genetic background. The neurosteroid allopregnanolone (ALLO) is a positive allosteric modulator of the GABAA receptor and has been shown to have an antidepressant-like effect in animals. This study aimed to assess the behavioral effect of ALLO in animals with different backgrounds of depressive-like activity. An initial population (F0) of male and female Wistar rats was screened for immobility behavior utilizing the Forced Swim Test (FST)...
June 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29905900/knee-alignment-in-adolescents-is-correlated-with-participation-in-weight-bearing-sports
#11
Laurens De Cock, Jan Dauwe, Lukas A Holzer, Johan Bellemans
PURPOSE: Weight-bearing sports might influence the alignment of the lower extremities during growth. The relationship between participation in weight-bearing sports and the alignment of the lower extremities in adolescents has not been adequately studied yet. The aim of the study was to investigate whether sports participation during growth in early adolescence is correlated with the development of genu varum. METHODS: The design was a correlation study in which 1008 (564 boys, 444 girls) healthy adolescents (from 12 to 19 years of age) were recruited in secondary schools...
June 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29905608/the-gracilis-free-flap-is-a-viable-option-for-large-extremity-wounds
#12
Nicholas A Calotta, Rachel Pedreira, E Gene Deune
BACKGROUND: Traditionally, the gracilis free flap is used for coverage of small- to medium-sized wounds (<50 cm) or as a functional muscle transfer. The purpose of this study is to examine the use of the gracilis free flap in the reconstruction of large extremity wounds (>100 cm). METHODS: We retrospectively reviewed records of 34 patients who underwent extremity soft-tissue reconstruction using gracilis free flaps for wounds larger than 100 cm from 1998 to 2016...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29905414/tips-for-pedal-access-technical-evolution-and-review
#13
Ansar Z Vance, Daniel A Leung, Timothy W Clark
Pedal access has become an indispensable technique for endovascular therapy of complex lower extremity peripheral vascular disease. From an option as a single access in a patient lacking traditional access approaches to a critical maneuver in combined antegrade-retrograde approaches during the treatment of complex chronic total occlusions, pedal access is an essential tool for any endovascular physician treating peripheral arterial disease. Anticipatory planning is critical in the successful utilization of pedal access...
June 14, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29905043/-short-term-effectiveness-of-percutaneous-endoscopic-lumbar-discectomy-in-treatment-of-buttock-pain-associated-with-lumbar-disc-herniation
#14
Peng Cai, Qingquan Kong, Yueming Song
Objective: To evaluate the short-term effectiveness of percutaneous endoscopic lumbar discectomy (PELD) in treatment of buttock pain associated with lumbar disc herniation. Methods: Between June 2015 and May 2016, 36 patients with buttock pain associated with lumbar disc herniation were treated with PELD. Of 36 cases, 26 were male and 10 were female, aged from 18 to 76 years (mean, 35.6 years). The disease duration ranged from 3 months to 10 years (mean, 14 months)...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904952/baicalin-effects-on-rats-with-spinal-cord-injury-by-anti-inflammatory-and-regulating-the-serum-metabolic-disorder
#15
Shufeng Kang, Shizhao Liu, Hongzhu Li, Dapeng Wang, Xiangbei Qi
Baicalin had neuroprotective effects on inhibiting neuronal cell apoptosis induced by spinal cord ischemic injury. This study aimed to explore the protective effects of Baicalin on rats with spinal cord injury (SCI) and its mechanism of action. The recovery of spinal cord nerve function in rats was evaluated by the Basso, Beattie, and Bresnahan (BBB) score and the combine behavioral score (CBS). The expressions of cytokines tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6 were detected by the enzyme-linked immunosorbent assay method...
June 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29904799/internal-blue-water-footprint-of-municipal-consumption-a-case-study-for-turkey
#16
Hülya Boyacıoğlu
This study aimed to develop a common approach to investigate (blue) water footprint of consumption of municipalities. Analysis framework consists of two distinct phases as: water abstraction profile and water distribution and water use profile. In the proposed approach municipal water footprint (WFmunicipal ) comprises three components: domestic water footprint (WFdomestic ), industrial/commercial water footprint (WFindustrial/commercial ), and public water footprint (WFpublic ). The application of the methodology was demonstrated in Turkey...
June 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29904700/data-on-the-effect-of-geological-and-meteorological-parameters-on-indoor-radon-and-thoron-level-case-study-kermanshah-iran
#17
Meghdad Pirsaheb, Farid Najafi, Lida Hemati, Touba Khosravi, Hooshmand Sharafi
The present study was aimed to evaluate the relationship between indoor radon and thoron concentrations, geological and meteorological parameters. The radon and thoron concentrations were determined in three hospitals in Kermanshah, the west part of Iran, using the RTM-1688-2 radon meter. Also, the type and porosity of the underlying soil and the meteorological parameters such as temperature, humidity, atmospheric pressure, rainfall and wind speed were studied and the obtained results analyzed using STATA-Ver...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904613/prevalence-of-musculoskeletal-pain-in-association-with-serum-25-hydroxyvitamin-d-concentrations-in-patients-with-type-2-diabetes-mellitus
#18
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
The aim of the present study was to investigate the prevalence of musculoskeletal pain in patients with type 2 diabetes mellitus (T2DM) in association with 25-hydroxyvitamin D levels, anxiety, depression and neuropathy. A cross-sectional study was conducted involving a total of 124 T2DM patients. Musculoskeletal pain was determined by self-reporting of painful body sites. Pain intensity was assessed using a scale of 0-10. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. Neuropathy was assessed using the PainDETECT questionnaire...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29904601/incidence-and-risk-factors-for-complications-after-definitive-skeletal-fixation-of-lower-extremity-in-multiple-injury-patients-a-retrospective-chart-review
#19
Thananit Sangkomkamhang, Wilaiphorn Thinkhamrop, Bandit Thinkhamrop, Wongsa Laohasiriwong
Background : The management of multiple injuries is complex. Type and timing of treatment for lower extremity fractures is a controversial subject. Although many studies have demonstrated the safety and effectiveness of early treatment, others have suggested that early definitive stabilization may cause complications, especially with chest and head injuries. The aim of this study was to determine the complications and effects of timing of fixation, and investigate risk factors for complications in multiple injuries patients with lower extremity fractures...
2018: F1000Research
https://www.readbyqxmd.com/read/29904405/predictive-value-of-platelet-aggregation-rate-in-postpartum-deep-venous-thrombosis-and-its-possible-mechanism
#20
Mingxia Sun, Chongdong Liu, Na Zhao, Kaikai Meng, Zhenyu Zhang
The present study investigated the predictive value of the platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism. From January 2014 to January 2016, 23 patients with postpartum deep vein thrombosis of lower extremity treated in the Department of Obstetrics of Beijing Chaoyang Hospital were as assigned as the observation group. At the same time, 25 cases with normal recovery were assigned as the control group. Blood samples were collected from all the subjects. The platelet aggregation rate was measured using a platelet aggregation apparatus...
June 2018: Experimental and Therapeutic Medicine
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