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JOURNAL ARTICLE
Tun Wang, Peng Lu, Zicheng Wan, Zhenyu He, Siyuan Cheng, Yang Zhou, Sheng Liao, Mo Wang, Tianjian Wang, Chang Shu
Arteriovenous grafts (AVGs) have emerged as the preferred option for constructing hemodialysis access in numerous patients. Clinical trials have demonstrated that decellularized vascular graft exhibits superior patency and excellent biocompatibility compared to polymer materials; however, it still faces challenges such as intimal hyperplasia and luminal dilation. The absence of suitable animal models hinders our ability to describe and explain the pathological phenomena above and in vivo adaptation process of decellularized vascular graft at the molecular level...
2024: Regenerative Biomaterials
#22
MULTICENTER STUDY
Michael D Keller, Patrick J Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C Dvorak, Michael R Verneris, Donald B Kohn, Sung-Yun Pai, Blachy J Dávila Saldaña, Benjamin Hanisch, Troy C Quigg, Roberta H Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A Jensen-Wachspress, Christopher A Lazarski, Gelina Sani, John M Idso, Haili Lang, Pamela Chansky, Chase D McCann, Jay Tanna, Allistair A Abraham, Jennifer L Webb, Abeer Shibli, Amy K Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N De Oliveira, Mark T Vander Lugt, Christen L Ebens, Victor M Aquino, Jeffrey J Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T Zambidis, Elizabeth Gourdine, Catherine M Bollard, Michael A Pulsipher
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus...
April 18, 2024: Nature Communications
#23
JOURNAL ARTICLE
Kosuke Ino, Mana Wachi, Yoshinobu Utagawa, An Konno, Masahiro Takinoue, Hiroya Abe, Hitoshi Shiku
Three-dimensional (3D)-cultured cells have attracted the attention of researchers in tissue engineering- and drug screening-related fields. Among them, 3D cellular fibers have attracted significant attention because they can be stacked to prepare more complex tissues and organs. Cellular fibers are widely fabricated using extrusion 3D bioprinters. For these applications, it is necessary to evaluate cellular activities, such as the oxygen consumption rate (OCR), which is one of the major metabolic activities...
May 22, 2024: Analytica Chimica Acta
#24
JOURNAL ARTICLE
G Y Wang, L Liao, W D Tian
Objective: To investigate the impact of intermittent senescent cell clearance on the proliferation and differentiation of dental pulp stem cells (DPSC) in long-term, large-scale expansion, and to explore strategies for maintaining the youthful state of DPSC in vitro. Methods: Human-derived dental pulp stem cells were isolated from healthy permanent teeth extracted for orthodontic or impeding eruption reasons, provided by the Department of Oral and Maxillofacial Surgery at West China Hospital of Stomatology, Sichuan University...
April 18, 2024: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
#25
JOURNAL ARTICLE
Lourdes Cordón, Pedro Chorão, Beatriz Martín-Herreros, Juan Montoro, Aitana Balaguer, Manuel Guerreiro, Marta Villalba, Ana Facal, Pedro Asensi, Pilar Solves, Inés Gómez, Marta Santiago, Brais Lamas, Ana Bataller, Pablo Granados, Amparo Sempere, Guillermo F Sanz, Miguel A Sanz, Jaime Sanz
This study aimed to investigate the kinetics of immune recovery following umbilical cord blood transplantation (UCBT) in adults who received a myeloablative conditioning (MAC) regimen and antithymocyte globulin (ATG). While the immune recovery kinetics has been extensively studied in pediatric UCBT recipients, limited data exist for adults. We conducted a comprehensive analysis of 221 consecutive adult patients who underwent UCBT with MAC and ATG at a single institution. Our objective was to evaluate the influence of patient, disease, and transplant factors, along with acute graft-versus-host disease (aGVHD), on immune reconstitution and overall survival...
April 18, 2024: Annals of Hematology
#26
Tamim Alsuliman, Clotilde Aubrun, Jacques Olivier Bay, Yves Beguin, Camille Bigenwald, Eolia Brissot, Yves Chalandon, Patrice Chevallier, Simona Pagliuca, Léonardo Magro, Micha Srour
Chimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonization workshop, gathering a group of experts who analyzed this topic, has been conceived for the optimization of the management of patients presenting with post-CAR-T cell hematological toxicities...
April 16, 2024: Bulletin du Cancer
#27
JOURNAL ARTICLE
Gabriel Salinas Cisneros, Christopher C Dvorak, Janel Long-Boyle, Sandhya Kharbanda, Kristin A Shimano, Alexis Melton, Julia Chu, Lena E Winestone, Jasmeen Dara, James N Huang, Michelle L Hermiston, Matt Zinter, Christine S Higham
INTRODUCTION: Sinusoidal obstructive syndrome (SOS), or veno-occlusive disease (VOD), of the liver has been recognized as a complex, life-threatening complication in the post-hematopoietic stem cell transplant (HSCT) setting. The diagnostic criteria for SOS have evolved over the last several decades with a greater understanding of the underlying pathophysiology, with two recent diagnostic criteria introduced in 2018 (EBMT criteria) and 2020 (Cairo criteria). OBJECTIVE: We sought out to evaluate the performance characteristics in diagnosing and grading SOS in pediatric patients of the four different diagnostic criteria (Baltimore, Modified Seattle, EBMT, and Cairo) and severity grading systems (defined by the EBMT and Cairo criteria)...
April 15, 2024: Transplantation and cellular therapy
#28
REVIEW
Mariam Darwish, Rojine El Hajj, Luna Khayat, Nada Alaaeddine
Autism spectrum disorder (ASD) is a neurodevelopmental illness characterized by impaired social interaction and restricted repetitive behaviors or interests. The rising prevalence of ASD diagnosis has triggered a surge in research into investigating the underlying neuropathological processes and finding new therapeutic approaches. ASD is characterized by neuroinflammation and dysregulation of neuro-immune cross-talk, which suggests that stem cell treatment might be a potential therapeutic approach. The beneficial and restorative effects of stem cells are mainly due to their paracrine activity, in which stem cells generate and release extracellular vesicles such as exosomes and distinct secreted non-vesicle soluble proteins, including, growth factors, chemokines, cytokines, and immunomodulatory molecules referred to as the Secretome...
April 17, 2024: Stem cell reviews and reports
#29
JOURNAL ARTICLE
Omid Reza Zekavat, Yasaman Movahednezhad, Amin Shahsavani, Sezaneh Haghpanah, Negin Shokrgozar, Hossein Golmoghaddam, Mehdi Kalani, Mohammad Reza Bordbar, Nargess Arandi
BACKGROUND: Development of antibodies against infused Factor VIII (FVIII) or "inhibitors" represents a major challenge following FVIII replacement therapy in patients with hemophilia A (HA). Recent studies have shown that certain cellular compartments of the immune system contribute to the production of such antibodies. Herein, we determined the frequency of class-switched CD19+ IgD- CD27+ /non-class-switched CD19+ IgD+ CD27+ memory B cell subsets and CD19+ CD27hi CD38hi plasmablasts in patients with severe HA and their association with the development of inhibitors in these patients...
April 16, 2024: Blood Research
#30
REVIEW
Abdollah Jafarzadeh, Marzieh Motaghi, Sanand Kumar Patra, Zahra Jafarzadeh, Maryam Nemati, Bhaskar Saha
Neutrophils are the most frequent immune cell type in peripheral blood, performing an essential role against pathogens. People with neutrophil deficiencies are susceptible to deadly infections, highlighting the importance of generating these cells in host immunity. Neutrophils can be generated from hematopoietic progenitor cells (HPCs) and embryonic stem cells (ESCs) using a cocktail of cytokines. In addition, induced pluripotent stem cells (iPSCs) can be differentiated into various functional cell types, including neutrophils...
March 30, 2024: Cytotherapy
#31
JOURNAL ARTICLE
Dina Averbuch, Gloria Tridello, Lotus Wendel, Maija Itälä-Remes, Ilana Oren, Michal Karas, Nicole Blijlevens, Yves Beguin, Annoek Broers, Elisabetta Calore, Chiara Cattaneo, Cecilia Isaksson, Christine Robin, Alain Gadisseur, Johan Maertens, Ann De Becker, Catherina Lueck, Elisabetta Metafuni, Herbert Pichler, Marina Popova, Ron Ram, Moshe Yeshurun, Malgorzata Mikulska, Rafael de la Camara, Jan Styczynski
BACKGROUND: Listeriosis is rare after hematopoietic stem cell transplantation (HCT). Little is known about listeriosis in this population. OBJECTIVES: To describe listeriosis following HCT and assess risk factors for listeriosis. STUDY DESIGN: In this retrospective international case control study, we described 41 listeriosis episodes during 2000-2021 in HCT recipients (111 transplant centers; 30 countries) and assessed risk factors for listeriosis by comparing to matched controls...
April 13, 2024: Transplantation and cellular therapy
#32
JOURNAL ARTICLE
Kehong Liu, Kiyoshi Sakai, Junna Watanabe, Jiao Dong, Hiroshi Maruyama, Xinheng Li, Hideharu Hibi
Systemic transplantation of mesenchymal stem cells (MSCs) and conditioned medium derived from MSCs have been reported to recover bone loss in animal models of osteoporosis; however, the underlying mechanisms remain unclear. We recently reported that extracellular vesicles released from human mesenchymal stem cells (hMSCs) prevent senescence of stem cells in bisphosphonate-related osteonecrosis of the jaw model. In this study, we aimed to compare the effects of conditioned medium (hMSCs-CM) from early and late passage hMSCs on cellular senescence and to verify the benefits of CM from early passage hMSCs in mitigating the progression of osteoporosis through the prevention of cellular senescence...
April 1, 2024: Biochemical and Biophysical Research Communications
#33
JOURNAL ARTICLE
Kento Takaya, Kazuo Kishi
The skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in combination with quercetin (D + Q) on senescent human skin fibroblasts and aging human skin...
April 15, 2024: Biogerontology
#34
JOURNAL ARTICLE
Francesca Lazzeri-Barcelo, Pierpaolo Ciardo, Barbara Leibiger, Ingo B Leibiger, Per-Olof Berggren, Noah Moruzzi
Biomedical studies of the liver in mammals are hindered by the lack of methods for in vivo noninvasive longitudinal imaging at cellular resolution. Until now, optical imaging of the liver in situ is possible by intravital imaging, which offers high-resolution imaging at the cellular level but cannot be performed multiple times and, therefore, longitudinally in the same animal. Noninvasive imaging methods, such as bioluminescence, allow repeated imaging sessions on the same animal but do not achieve cell resolution...
March 29, 2024: Journal of Visualized Experiments: JoVE
#35
JOURNAL ARTICLE
Andrew H Karaba, Zoe Swank, Sarah Hussain, Margaret Chahoud, Christine M Durand, Dorry L Segev, Mark A Robien, Peter S Heeger, Christian P Larsen, Aaron A R Tobian, David R Walt, William A Werbel
BACKGROUND: Kidney transplant recipients (KTRs) generate lower antibody responses to messenger RNA (mRNA)-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination, yet precise mechanisms for this poor response remain uncertain. One potential contributor is suboptimal spike antigen (sAg) translation and expression owing to transplant immunosuppression, which might lead to insufficient exposure to develop humoral and/or cellular immune responses. METHODS: Within a single-arm clinical trial, 65 KTRs underwent ultrasensitive plasma sAg testing before, and 3 and 14 days after, the third mRNA vaccine doses...
April 15, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
#36
Bryce R Christensen, Chung-Ting J Kou, Lauren E Lee
We present a rare case of hemophagocytic lymphohistiocytosis (HLH) secondary to nasal-type extranodal natural killer/T-cell lymphoma (ENKL). Nasal-type ENKL is a rare subtype of non-Hodgkin's lymphoma usually associated with Epstein-Barr virus (EBV). The patient was a 19-year-old woman who presented with facial numbness, diminished hearing, and dysgeusia. She was febrile with palatal necrosis, loss of gag reflex, and cranial nerve palsies. Labs revealed neutropenia. Broad-spectrum antimicrobials, including amphotericin, were started...
March 2024: Curēus
#37
JOURNAL ARTICLE
Rita Eid, Anne Scemla, Magali Giral, Nadia Arzouk, Dominique Bertrand, Marie-Noëlle Peraldi, Laurent Mesnard, Helene Longuet, Mehdi Maanaoui, Geoffroy Desbuissons, Edouard Lefevre, Renaud Snanoudj
BACKGROUND: Efficacy and safety of belatacept have not been specifically reported for kidney transplantations from donors after circulatory death. METHODS: In this retrospective multicenter paired kidney study, we compared the outcome of kidney transplantations with a belatacept-based to a calcineurin inhibitor (CNI)-based immunosuppression. We included all kidney transplant recipients from donors after uncontrolled or controlled circulatory death performed in our center between February 2015 and October 2020 and treated with belatacept (n = 31)...
May 2024: Transplantation Direct
#38
Megan E McNamara, Sidharth S Jain, Kesha Oza, Vinona Muralidaran, Amber J Kiliti, A Patrick McDeed, Digvijay Patil, Yuki Cui, Marcel O Schmidt, Anna T Riegel, Alexander H K Kroemer, Anton Wellstein
Post-transplant complications reduce allograft and recipient survival. Current approaches for detecting allograft injury non-invasively are limited and do not differentiate between cellular mechanisms. Here, we monitor cellular damages after liver transplants from cell-free DNA (cfDNA) fragments released from dying cells into the circulation. We analyzed 130 blood samples collected from 44 patients at different time points after transplant. Sequence-based methylation of cfDNA fragments were mapped to patterns established to identify cell types in different organs...
April 5, 2024: bioRxiv
#39
Russell W Cochrane, Rob A Robino, Bryan Granger, Eva Allen, Silvia Vaena, Martin J Romeo, Aguirre A de Cubas, Stefano Berto, Leonardo M R Ferreira
Regulatory T cells (Tregs) are promising cellular therapies to induce immune tolerance in organ transplantation and autoimmune disease. The success of chimeric antigen receptor (CAR) T-cell therapy for cancer has sparked interest in using CARs to generate antigen-specific Tregs. Here, we compared CAR with endogenous T cell receptor (TCR)/CD28 activation in human Tregs. Strikingly, CAR Tregs displayed increased cytotoxicity and diminished suppression of antigen-presenting cells and effector T (Teff) cells compared with TCR/CD28 activated Tregs...
April 1, 2024: bioRxiv
#40
JOURNAL ARTICLE
Peter Ghali, Ramez M Ibrahim, David Hodge, Launia White, Hani M Wadei
BACKGROUND: Simultaneous liver kidney (SLK) transplant protects against acute cellular rejection. In 2017, UNOS implemented a "safety net" policy to allow patients with renal recovery to avoid renal transplantation. Whether kidney after liver transplantation (KALT) increases the risk of rejection is unknown. METHODS: We performed a retrospective analysis of the Organ Procurement and Transplantation Network (OPTN) database of adult patients who received liver transplant, SLK or KALT between 2010 and 2020...
April 2024: Clinical Transplantation
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