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https://www.readbyqxmd.com/read/28550041/central-nervous-system-involvement-in-acute-lymphoblastic-leukemia-is-mediated-by-vascular-endothelial-growth-factor
#1
Vera Münch, Luca Trentin, Julia Herzig, Salih Demir, Felix Seyfried, Johann M Kraus, Hans A Kestler, Rolf Köhler, Thomas F E Barth, Geertruy Te Kronnie, Klaus-Michael Debatin, Lüder H Meyer
In acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is a major clinical concern. Despite non-detectable CNS leukemia in many cases, prophylactic CNS-directed conventional intrathecal chemotherapy is required for relapse free survival indicating subclinical CNS manifestation in most patients. However, CNS-directed therapy is associated with long-term sequelae including neurocognitive deficits and secondary neoplasms. Therefore, molecular mechanisms and pathways mediating leukemia cell entry into the CNS need to be understood in order to identify targets for prophylactic and therapeutic interventions and develop alternative CNS-directed treatment strategies...
May 26, 2017: Blood
https://www.readbyqxmd.com/read/28546567/thymic-homing-of-activated-cd4-t-cells-induces-degeneration-of-the-thymic-epithelium-through-excessive-rank-signaling
#2
Chen Yin, Xiao-Yan Pei, Hui Shen, Ya-Nan Gao, Xiu-Yuan Sun, Wei Wang, Qing Ge, Yu Zhang
Activated T cells have been shown to be able to recirculate into the thymus from the periphery. The present study was aimed to elucidate the functional consequences of thymic homing of activated T cells upon developing thymocytes and thymic epithelial cells (TEC). In the presence of activated T cells, especially CD4(+) T cells, T cell development was found to be inhibited in thymic organ cultures with markedly reduced cellularity. Thymic transplantation demonstrated that the inhibitory effect was most likely due to a defective microenvironment...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28546528/comparative-proteomic-profiling-of-sera-from-patients-with-refractory-multiple-myeloma-reveals-potential-biomarkers-predicting-response-to-bortezomib-based-therapy
#3
Magdalena Łuczak, Tadeusz Kubicki, Zuzanna Rzetelska, Tomasz Szczepaniak, Anna Przybyłowicz-Chalecka, Błażej Ratajczak, Joanna Czerwińska-Rybak, Adam Nowicki, Monika Joks, Andrzej Jakubowiak, Mieczysław Komarnicki, Dominik Dytfeld
INTRODUCTION    In the era of novel agent implementation in multiple myeloma (MM) regimens, drug resistance has become a key factor undermining the results of treatment. Identifying biomarkers allows the prediction of therapy outcomes with specific agents and may lead to the avoidance of resistance. OBJECTIVES    This study aimed to identify biomarkers in the pretreatment sera of patients with refractory/relapsed MM that differ from those in the sera of patients who achieved a better depth of response from bortezomib-containing therapy...
May 25, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28546469/green-tea-egcg-enhances-cardiac-function-restoration-through-expression-of-survival-signaling-in-dm-rats-with-autologous-adipose-tissue-derived-stem-cell
#4
Tung-Sheng Chen, Show-Yih Liou, Chia-Hua Kuo, Lung-Fa Pan, Yu-Lan Yeh, Jeffery Liou, V Vijaya Padma, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang
The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM), may be synergistically enhanced by oral treatment with green tea epigallocatechin gallat (ECCG). Wistar rats were divided into sham, DM, DM+ADSC (autologous transplanted 1x106 cells/rat) and DM+ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated for all rats and investigations were performed after 2-months treatment...
May 25, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28545651/the-dichotomy-of-placenta-derived-cells-in-cancer-growth
#5
Antonietta R Silini, Sara Cancelli, Patrizia Bonassi Signoroni, Anna Cargnoni, Marta Magatti, Ornella Parolini
Placenta-derived mesenchymal stromal cells (MSC) have often been considered to linger behind their equivalents from other tissues, such as MSC from bone marrow, in many aspects including their therapeutic potential in regenerative medicine. Nowadays however, it is clear that certain aspects make placental MSC attractive as a cellular therapy, such as their lack of ethical concerns and ease of isolation from human term placenta, a material long regarded as biological waste. Moreover, placental MSC virtually lack expression of human leukocyte antigens and co-stimulatory molecules, making them very attractive for transplantation in allogeneic settings...
May 18, 2017: Placenta
https://www.readbyqxmd.com/read/28544604/thymic-peripheral-crosstalk-in-lymphodepletion-therapy
#6
EDITORIAL
M E Snyder, D L Farber
T cell depletion is widely used as induction therapy in solid organ transplants and particularly in kidney transplantation, to reduce the episodes of acute cellular rejection. The resultant reduction in T cell numbers is usually temporary, as T cells are actively replenished due to thymic output and/or lymphopenia-induced proliferation of remaining, depletion-resistant T cells. However, the extent of T cell replenishment and the persistence of lymphopenia varies between individuals, with potential impacts on protective or pathogenic immune responses...
May 22, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28544497/cell-tracking-using-gold-nanoparticles-and-computed-tomography-imaging
#7
REVIEW
Rinat Meir, Rachela Popovtzer
Cell-based therapies utilize transplantation of living cells with therapeutic traits to alleviate numerous diseases and disorders. The use of such biological agents is an attractive alternative for diseases that existing medicine cannot effectively treat. Although very promising, translating cell therapy to the clinic has proven to be challenging, due to inconsistent results in preclinical and clinical studies. To examine the underlying cause for these inconsistencies, it is crucial to noninvasively monitor the accuracy of cell injection, and cell survival and migration patterns...
May 24, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28543763/7-8-3-trihydroxyflavone-protects-h-r-induced-apoptosis-and-induces-in-vivo-growth-of-human-embryonic-stem-cell-derived-cardiomyocytes
#8
Jiaxiang Li, Cuiping Wang, Bao Zhang Baiyun Tang
BACKGROUND: Cellular therapy of human embryonic stem cell-derived cardiomyocytes (hES-CMs) holds great promise for regenerating infarcted cardiac tissues. Yet, the major challenge remains as little cells survived after grafting. In this study, we examined whether treating hES-CMs with 7, 8, 3'-Trihydroxyflavone (THF) may improve hES-CMs developments both in vitro and in vivo. METHOD: HES-CMs were differentiated in vitro, and treated with 5 μ59M THF for 24 h...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28542651/cellular-migration-transition-and-interaction-during-regeneration-of-the-sponge-hymeniacidon-heliophila
#9
Cristiano C Coutinho, Ivone de Andrade Rosa, John Douglas de Oliveira Teixeira, Leonardo R Andrade, Manoel Luis Costa, Claudia Mermelstein
Sponges have a high capacity for regeneration and this process improves biomass production in some species, thus contributing to a solution for the biomass supply problem for biotechnological applications. The aim of this work is to characterize the dynamics of cell behavior during the initial stages of sponge regeneration, using bright-field microscopy, confocal microscopy and SEM. We focused on the first 20 h of regeneration, during which blastema formation and epithelium initialization occur. An innovative sponge organotypic culture of the regenerating internal region is described and investigated by confocal microscopy, cell transplantation and vital staining...
2017: PloS One
https://www.readbyqxmd.com/read/28542092/approach-to-skin-and-soft-tissue-infections-in-non-hiv-immunocompromised-hosts
#10
Victoria E Burke, Fred A Lopez
PURPOSE OF REVIEW: Skin and soft tissue infections are frequent contributors to morbidity and mortality in the immunocompromised host. This article reviews the changing epidemiology and clinical manifestations of the most common cutaneous pathogens in non-HIV immunocompromised hosts, including patients with solid organ transplants, stem cell transplants, solid tumors, hematologic malignancies, and receiving chronic immunosuppressive therapy for inflammatory disorders. RECENT FINDINGS: Defects in the innate or adaptive immune response can predispose the immunocompromised host to certain cutaneous infections in a predictive fashion...
May 24, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28541773/induction-of-salivary-gland-like-cells-from-dental-follicle-epithelial-cells
#11
Q L Xu, A Furuhashi, Q Z Zhang, C M Jiang, T-H Chang, A D Le
The dental follicle (DF), most often associated with unerupted teeth, is a condensation of ectomesenchymal cells that surrounds the tooth germ in early stages of tooth development. In the present study, we aim to isolate epithelial stem-like cells from the human DF and explore their potential differentiation into salivary gland (SG) cells. We demonstrated the expression of stem cell-related genes in the epithelial components of human DF tissues, and these epithelial progenitor cells could be isolated and ex vivo expanded in a reproducible manner...
May 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28541443/the-impact-of-multidisciplinary-care-on-early-morbidity-and-mortality-after-heart-transplantation
#12
Marie Schmidhauser, Julien Regamey, Nathalie Pilon, Manuel Pascual, Sam Rotman, Carlo Banfi, René Prêtre, Philippe Meyer, Jean-Philippe Antonietti, Roger Hullin
OBJECTIVES: The impact of multidisciplinary care on outcome after heart transplantation (HTx) remains unclear. METHODS: This retrospective study investigates the impact of multidisciplinary care on the primary end point 1-year all-cause mortality (ACM) and the secondary end point mean acute cellular rejection (ACR) grade within the first postoperative year. RESULTS: This study includes a total 140 HTx recipients (median age: 53.5 years; males: 80%; donor/recipient gender mismatch: 38...
May 24, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28540885/outcome-of-recipients-of-human-leukocyte-antigen-incompatible-kidney-transplants-who-underwent-desensitization-at-king-fahad-specialist-hospital-dammam-saudi-arabia
#13
Mohammed Abdulrahim Idris, Akhtar Hossain, Mohammed Abdulrahman Muntasir, Adnan Marmi, Ahmed Abdulfattah Aldajani, Yousef Mohammed Aljamaan, Mahmood Akhtar, Abdulrahman Housawi
In patients whom are highly sensitized immunologically, the benefit of kidney transplantation can be extended to this population through the utilization of organs from human leukocyte antigen incompatible (HLAi) donors. This retrospective observational study was designed to identify the incidence and predictors of acute antibody-mediated rejection/acute cellular rejection (AMR/ACR) in our kidney recipients from living kidney donors (sensitized and those with low immunologic risk). This single-center study has been conducted at King Fahad Specialist Hospital, Dammam (KFSH-D), Saudi Arabia; during the period of September 2008- August 2013...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28539455/functional-consequences-of-rna-5-terminal-deletions-on-coxsackievirus-b3-rna-replication-and-ribonucleoprotein-complex-formation
#14
Nicolas Lévêque, Magali Garcia, Alexis Bouin, Joseph H C Nguyen, Genevieve P Tran, Laurent Andreoletti, Bert L Semler
Group B coxsackieviruses are responsible for chronic cardiac infections. However, the molecular mechanisms by which the virus can persist in the human heart long after the signs of acute myocarditis have abated are still not completely understood. Recently, coxsackievirus B3 strains with 5' terminal deletions in genomic RNAs were isolated from a patient suffering from idiopathic dilated cardiomyopathy, suggesting that such mutant viruses may be the forms responsible for persistent infection. These deletions lacked portions of 5' stem-loop I, which is an RNA secondary structure required for viral RNA replication...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28536438/optimizing-radiotherapy-protocols-using-computer-automata-to-model-tumour-cell-death-as-a-function-of-oxygen-diffusion-processes
#15
Perrine Paul-Gilloteaux, Vincent Potiron, Grégory Delpon, Stéphane Supiot, Sophie Chiavassa, François Paris, Sylvain V Costes
The concept of hypofractionation is gaining momentum in radiation oncology centres, enabled by recent advances in radiotherapy apparatus. The gain of efficacy of this innovative treatment must be defined. We present a computer model based on translational murine data for in silico testing and optimization of various radiotherapy protocols with respect to tumour resistance and the microenvironment heterogeneity. This model combines automata approaches with image processing algorithms to simulate the cellular response of tumours exposed to ionizing radiation, modelling the alteration of oxygen permeabilization in blood vessels against repeated doses, and introducing mitotic catastrophe (as opposed to arbitrary delayed cell-death) as a means of modelling radiation-induced cell death...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536366/advances-in-the-use-of-regulatory-t-cells-for-the-prevention-and-therapy-of-graft-vs-host-disease
#16
REVIEW
Reshma Ramlal, Gerhard C Hildebrandt
Regulatory T (Tregs) cells play a crucial role in immunoregulation and promotion of immunological tolerance. Adoptive transfer of these cells has therefore been of interest in the field of bone marrow and solid organ transplantation, autoimmune diseases and allergy medicine. In bone marrow transplantation, Tregs play a pivotal role in the prevention of graft-verus-host disease (GvHD). This has generated interest in using adoptive Treg cellular therapy in the prevention and treatment of GvHD. There have been several barriers to the feasibility of Treg cellular therapy in the setting of hematopoietic stem cell transplantation (HSCT) which include low Treg concentration in peripheral blood, requiring expansion of the Treg population; instability of the expanded product with loss of FoxP3 expression; and issues related to the purity of the expanded product...
May 16, 2017: Biomedicines
https://www.readbyqxmd.com/read/28536320/-stress-response-mechanism-in-hematopoietic-stem-cells
#17
Keiyo Takubo
At steady state, hematopoietic stem cells(HSCs), the most undifferentiated cells in the hematological system, are kept quiescent in the cell cycle. Upon hematological stresses, including radiation, anti-cancer medication, infection, and transplantation, bone marrow HSCs enter the cell cycle and robustly repopulate the entire hematopoietic system via multi-lineage differentiation and self-renewal, partly due to the alteration of their surrounding microenvironment or niche. Such hematological repopulation activity is termed "stress hematopoiesis," an activity essential for homeostatic maintenance of blood production...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28536142/augmented-tme-o-glcnacylation-promotes-tumor-proliferation-through-the-inhibition-of-p38-mapk
#18
Kazumasa Moriwaki, Michio Asahi
O-GlcNAcylation is a dynamic O-linked glycosylation event that plays a crucial role in regulating cellular signaling. Recent studies indicate that increased O-GlcNAcylation is a general feature in cancer and contributes to various cancer phenotypes, including cell proliferation, survival, invasion, metastasis, and energy metabolism. However, the role of O-GlcNAcylation in the tumor microenvironment (TME) is not fully elucidated. Here, B16 melanoma cells were subcutaneously transplanted into O-GlcNAc transferase transgenic (Ogt-Tg) mice exhibiting elevated O-GlcNAcylation to examine the effect of O-GlcNAcylation in the TME on tumor progression...
May 23, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28533168/prospects-for-therapeutic-mitochondrial-transplantation
#19
REVIEW
Jenna L Gollihue, Alexander G Rabchevsky
Mitochondrial dysfunction has been implicated in a multitude of diseases and pathological conditions- the organelles that are essential for life can also be major players in contributing to cell death and disease. Because mitochondria are so well established in our existence, being present in all cell types except for red blood cells and having the responsibility of providing most of our energy needs for survival, then dysfunctional mitochondria can elicit devastating cellular pathologies that can be widespread across the entire organism...
May 19, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28531995/scavenging-free-radicals-and-soaring-osteoinduction-by-extra-cellular-matrix-protein-based-nanocomposites-on-degenerative-bone-treatments
#20
Kavitha Kandiah, Navaneethan Duraisamy, Vinoth Amirthalingam, Balagurunathan Ramasamy
A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Here, they are three different nano-composites prepared such as nano-TiO2 with chitosan (TC), nano-TiO2 with chondroitin 4-sulfate (TG), and nano-TiO2 with chitosan and chondroitin 4-sulfate (TCG), whereas nano-TiO2 act as a control...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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