Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Chihiro Kadooka, Yutaka Tanaka, Rintaro Kishida, Daisuke Hira, Takuji Oka
UNLABELLED: The cellular surface of the pathogenic filamentous fungus Aspergillus fumigatus is enveloped in a mannose layer, featuring well-established fungal-type galactomannan and O -mannose-type galactomannan. This study reports the discovery of cell wall component in A. fumigatus mycelium, which resembles N -glycan outer chains found in yeast. The glycosyltransferases involved in its biosynthesis in A. fumigatus were identified, with a focus on two key α-(1→2)-mannosyltransferases, Mnn2 and Mnn5, and two α-(1→6)-mannosyltransferases, Mnn9 and Van1...
April 23, 2024: MSphere
#22
JOURNAL ARTICLE
Marek Niedoszytko, Aleksandra Gorska, Knut Brockow, Patrizia Bonadonna, Magdalena Lange, Hanneke Kluin-Nelemans, Hanneke Oude-Elberink, Vito Sabato, Khalid Shoumariyeh, Dagmar von Bubnoff, Sabine Müller, Anja Illerhaus, Michael Doubek, Irena Angelova-Fischer, Olivier Hermine, Michel Arock, Chiara Elena, Luca Malcovati, Akif Selim Yavuz, Tanja Daniela Schug, Anna Belloni Fortina, Várkonyi Judit, Jason Gotlib, Jens Panse, Vladan Vucinic, Andreas Reiter, Juliana Schwaab, Massimo Triggiani, Mattias Mattsson, Christine Breynaert, Jan Romantowski, Roberta Zanotti, Elisa Olivieri, Alexander Zink, Annick van de Ven, Alex Stefan, Stephane Barete, Francesca Caroppo, Cecelia Perkins, Vanessa Kennedy, Deborah Christen, Mohamad Jawhar, Johannes Luebke, Roberta Parente, Kerstin Levedahl, Emir Hadzijusufovic, Karin Hartmann, Boguslaw Nedoszytko, Wolfgang R Sperr, Peter Valent
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up...
April 23, 2024: Allergy
#23
JOURNAL ARTICLE
Cooper Sadowski, Justin P Reinert
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: To investigate the safety and efficacy of direct oral anticoagulants (DOACs) in the treatment of the acute phase of heparin-induced thrombocytopenia (HIT)...
April 23, 2024: American Journal of Health-system Pharmacy: AJHP
#24
JOURNAL ARTICLE
João Pedro Rueda Furlan, Rafael da Silva Rosa, Micaela Santana Ramos, Lucas David Rodrigues Dos Santos, Eduardo Angelino Savazzi, Eliana Guedes Stehling
BACKGROUND: Klebsiella pneumoniae species complex (KpSC) is an important disseminator of carbapenemase-encoding genes, mainly blaKPC-2 and blaNDM-1 , from hospitals to the environment. Consequently, carbapenem-resistant strains can be spread through the agrifood system, raising concerns about food safety. Therefore, this study aimed to isolate carbapenem-resistant KpSC strains from agricultural and environmental sectors and characterize them by phenotypic, molecular, and genomic analyses...
April 23, 2024: Journal of the Science of Food and Agriculture
#25
REVIEW
Petja Marinova, Kristina Tamahkyarova
Peptides, both natural and synthetic, are well suited for a wide range of purposes and offer versatile applications in different fields such as biocatalysts, injectable hydrogels, tumor treatment, and drug delivery. The research of the better part of the cited papers was conducted using various database platforms such as MetalPDB. The rising prominence of therapeutic peptides encompasses anticancer, antiviral, antimicrobial, and anti-neurodegenerative properties. The metals Na, K, Mg, Ca, Fe, Mn, Co, Cu, Zn, and Mo are ten of the twenty elements that are considered essential for life...
April 8, 2024: BioTech (Basel)
#26
REVIEW
Anna Candoni, Gabriele Coppola
Menin inhibitors are new and promising agents currently in clinical development that target the HOX/MEIS1 transcriptional program which is critical for leukemogenesis in histone-lysine N-methyltransferase 2A-rearranged (KMT2Ar) and in NPM1-mutated (NPM1mut) acute leukemias. The mechanism of action of this new class of agents is based on the disruption of the menin-KMT2A complex (consisting of chromatin remodeling proteins), leading to the differentiation and apoptosis of AML cells expressing KMT2A or with mutated NPM1...
April 18, 2024: Hematology Reports
#27
JOURNAL ARTICLE
Eleanor Watts, Aarti Bashyal, Sean D Dunham, Christopher M Crittenden, Jennifer S Brodbelt
As the development of new biotherapeutics advances, increasingly sophisticated tandem mass spectrometry methods are needed to characterize the most complex molecules, including antibody drug conjugates (ADCs). Lysine-linked ADCs, such as trastuzumab-emtansine (T-DM1), are among the most heterogeneous biotherapeutics. Here, we implement a workflow that combines limited proteolysis with HCD-triggered EThcD and UVPD mass spectrometry for the characterization of the resulting middle-down large-sized peptides of T-DM1...
April 17, 2024: Antibodies
#28
JOURNAL ARTICLE
Julio Daimar Oliveira Correa, José Artur Bogo Chies
Hepatitis C is regarded as a global health issue caused by hepatitis C virus (HCV) infection. HCV is targeted for elimination by 2030 as a global public health goal. However, the COVID-19 pandemic has changed human circulation and prevented access to diagnostics and treatment to many other diseases, including hepatitis C. COVID-19 impacted HCV global elimination efforts with implications not fully comprehended yet. The high genetic variability in HCV makes the development of vaccines and pan-genotypic drug therapies a difficult task...
April 4, 2024: Epidemiologia (Basel)
#29
JOURNAL ARTICLE
Jens R Coorssen, Matthew P Padula
With growing recognition and acknowledgement of the genuine complexity of proteomes, we are finally entering the post-proteogenomic era. Routine assessment of proteomes as inferred correlates of gene sequences (i.e., canonical 'proteins') cannot provide the necessary critical analysis of systems-level biology that is needed to understand underlying molecular mechanisms and pathways or identify the most selective biomarkers and therapeutic targets. These critical requirements demand the analysis of proteomes at the level of proteoforms/protein species, the actual active molecular players...
April 19, 2024: Proteomes
#30
JOURNAL ARTICLE
Keith L Sanders, Astrid M Manuel, Andi Liu, Boyan Leng, Xiangning Chen, Zhongming Zhao
Alzheimer's Disease (AD) is a complex disease and the leading cause of dementia in older people. We aimed to uncover aspects of AD's pathogenesis that may contribute to drug repurposing efforts by integrating DNA methylation and genetic data. Implementing the network-based tool, a dense module search of genome-wide association studies (dmGWAS), we integrated a large-scale GWAS dataset with DNA methylation data to identify gene network modules associated with AD. Our analysis yielded 286 significant gene network modules...
April 1, 2024: Epigenomes
#31
REVIEW
Stephanie Pang, Arianne Duong, Chloe Siu, Amy Indorf
OBJECTIVE: There are currently 11 antibody-drug conjugates (ADC) that are FDA approved for use in oncologic disease states, with many more in the pipeline. The authors aim to review the pharmacokinetic profiles of the components of ADCs to engage pharmacist practitioners in practical considerations in the care of patients. This article provides an overview on the use of ADCs in the setting of organ dysfunction, drug-drug interactions, and management of on- and off-target adverse effects...
April 23, 2024: Journal of Oncology Pharmacy Practice
#32
JOURNAL ARTICLE
Yusuke Tanaka, Mototsugu Tanaka, Haruna Miyazawa, Ryohei Terashima, Makoto Miyazawa, Mutsuhiro Ikuma, Yoshihiko Tomita
Drug safety communications (DSCs) are essential tools for communicating important postmarket serious drug safety information to healthcare professionals and patients. Previous studies characterized DSCs issued by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA); however, knowledge about the activities of the Pharmaceuticals and Medical Devices Agency (PMDA)/the Ministry of Health, Labor and Welfare (MHLW) is limited. This study characterized DSCs by the PMDA/MHLW in comparison with previously reported DSCs by the FDA and the EMA...
April 2024: Clinical and Translational Science
#33
JOURNAL ARTICLE
Ruixia Zhao, Sinan Cheng, Xue Bai, Danying Zhang, Hongming Fang, Wanlin Che, Wenxuan Zhang, Yujuan Zhou, Wei Duan, Qiumin Liang, Li Xiao, Guochao Nie, Yingchun Hou
Hepatocellular carcinoma (HCC) is a digestive tract cancer with high mortality and poor prognosis, especially in China. Current chemotherapeutic drugs lead to poor prognosis, low efficacy, and high side effects due to weak targeting specificity and rapidly formed multidrug resistance (MDR). Based on the previous studies on the doxorubicin (DOX) formulation for cancer targeting therapy, we developed a novel DOX delivery formulation for the targeting chemotherapy of HCC and DOX resistant HCC. HCSP4 was previously screened and casein kinase 2α (CK2α) was predicted as its specific target on HCC cells in our lab...
April 2024: Biotechnology Journal
#34
REVIEW
Kang Jun Cho, Joon Chul Kim
INTRODUCTION: Bladder storage dysfunction is associated with low quality of life in men and remains a challenging field in pharmacotherapy because of low persistence followed by patient-perceived lack of efficacy and adverse effects. The persistent desire for the development of novel pharmacotherapy is evident, leading to numerous research efforts based on its pathophysiology. AREAS COVERED: This review describes the pathophysiology, current pharmacotherapeutic strategies, and emerging novel drugs for male bladder storage dysfunction...
April 23, 2024: Expert Opinion on Pharmacotherapy
#35
REVIEW
Rosa Pirchio, Renata S Auriemma, Alice Vergura, Rosario Pivonello, Annamaria Colao
INTRODUCTION: Disease control is essential to decrease morbidity burden and mortality in acromegaly patients. In the last decades, the availability of new drugs increased the rate of disease control. However, up to 55% of patients remain uncontrolled despite available treatment strategies in real-world data. The reasons for this finding may include poor adherence, inadequate tolerability, therapeutic inertia, and high costs. Since acromegaly is a chronic disease and medical therapy is usually life-long, patient's adherence to treatment is fundamental in both achieving and maintaining disease control...
April 23, 2024: Expert Opinion on Investigational Drugs
#36
JOURNAL ARTICLE
Yongkang Zhang, Hongwei Ma, Linsen Li, Chen Sun, Changshui Yu, Lansheng Wang, Duo Xu, Xu Song, Rutong Yu
Chemotherapy of glioblastoma (GBM) has not yielded success due to inefficient blood-brain barrier (BBB) penetration and poor glioma tissue accumulation. Aerobic glycolysis, as the main mode of energy supply for GBM, safeguards the rapid growth and proliferation of GBM while affecting the efficacy of radiotherapy and chemotherapy. Therefore, to effectively inhibit aerobic glycolysis, increase drug delivery efficiency and improve drug sensitivity, we successfully designed and prepared a novel TMZ nanocapsule (ApoE-MT/siPKM2 NC) for the combined delivery of siPKM2 and TMZ...
April 23, 2024: Advanced Materials
#37
JOURNAL ARTICLE
Charlotte Buckley, Matthew D Lee, Xun Zhang, Calum Wilson, John G McCarron
BACKGROUND AND PURPOSE: The single layer of cells lining all blood vessels, the endothelium, is a sophisticated signal co-ordination centre that controls a wide range of vascular functions including the regulation of blood pressure and blood flow. To co-ordinate activities, communication among cells is required for tissue level responses to emerge. While a significant form of communication occurs by the propagation of signals between cells, the mechanism of propagation in the intact endothelium is unresolved...
April 23, 2024: British Journal of Pharmacology
#38
REVIEW
Junjie Zhang, Jiani Zhou, Longguang Tang, Jiayi Ma, Ying Wang, Hui Yang, Xiaoxiao Wang, Wenpei Fan
Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles in tumor diagnosis and treatment lie in their ability to target drug delivery, minimizing toxicity to normal tissues while enhancing therapeutic efficacy. Moreover, their responsiveness to both endogenous and exogenous stimuli opens up new possibilities for integrating multiple treatment modalities...
April 23, 2024: Small
#39
REVIEW
Kruthika Iyer, Zhonghao Yan, Susan R Ross
Arenaviruses belonging to the Arenaviridae family, genus mammarenavirus, are enveloped, single-stranded RNA viruses primarily found in rodent species, that cause severe hemorrhagic fever in humans. With high mortality rates and limited treatment options, the search for effective antivirals is imperative. Current treatments, notably ribavirin and other nucleoside inhibitors, are only partially effective and have significant side effects. The high lethality and lack of treatment, coupled with the absence of vaccines for all but Junín virus, has led to the classification of these viruses as Category A pathogens by the Centers for Disease Control (CDC)...
2024: Frontiers in Microbiology
#40
REVIEW
Jiaming Lei, Jianbao Yang, Cuiyu Bao, Feifei Lu, Qing Wu, Zihan Wu, Hong Lv, Yanhong Zhou, Yifei Liu, Ni Zhu, You Yu, Zhipeng Zhang, Meichun Hu, Li Lin
Isorhamnetin (ISO) is a phenolic compound belonging to flavonoid family, showcasing important in vitro pharmacological activities such as antitumor, anti-inflammation, and organ protection. ISO is predominantly extracted from Hippophae rhamnoides L . This plant is well-known in China and abroad because of its "medicinal and food homologous" characteristics. As a noteworthy natural drug candidate, ISO has received considerable attention in recent years owing to its low cost, wide availability, high efficacy, low toxicity, and minimal side effects...
2024: Frontiers in Pharmacology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
