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https://www.readbyqxmd.com/read/29045915/acute-psychoactive-effects-of-intravenous-ketamine-during-treatment-of-mood-disorders-analysis-of-the-clinician-administered-dissociative-state-scale
#1
Gerrit I van Schalkwyk, Samuel T Wilkinson, Larry Davidson, Wendy K Silverman, Gerard Sanacora
INTRODUCTION: Ketamine has rapid-acting antidepressant effects. Frequently, ketamine administration also causes acute psychoactive effects - in trials, these effects are commonly measured using the Clinician Administered Dissociative State Scale (CADSS). However, the CADSS was not designed for this specific purpose, having been validated in other clinical contexts, and anecdotally does not appear to fully capture ketamine's acute psychoactive effects. METHODS: Data were obtained from 110 individuals with mood disorders (predominantly major depressive disorder) who underwent intravenous ketamine infusion...
September 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29042527/-biomarkers-for-mood-disorders-and-a-novel-antidepressant-r-ketamine
#2
Kenji Hashimoto
Depression is often misdiagnosed as major depressive disorder in patients with bipolar disorder. Therapeutic drugs for these two disorders are quite different, but the anesthetic ketamine shows fast-acting antidepressant effects in treatment-resistant patients with these disorders. Here, we discuss biomarkers for both disorders, recent findings regarding ketamine, and predictable biomarkers for ketamine's antidepressant actions.
October 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29036835/therapeutic-role-of-long-non-coding-rna-tcons_00019174-in-depressive-disorders-is-dependent-on-wnt-%C3%AE-catenin-signaling-pathway
#3
Xinqiang Ni, Yingzhao Liao, Limin Li, Xiaoli Zhang, Zhengzhi Wu
Chronic stress is one of the major causes that lead to major depressive disorder (MDD), which is a prevalent mood disorder worldwide. Lots of MDD patients could not benefit from available medication due to the complex etiology of MDD. Recently, long non-coding RNAs (lncRNAs), molecular switches of downstream genes expression, have been reported to be involved in the pathogenesis of MDD. LncRNA TCONS_00019174 has been implicated in MDD risk and antidepressant effects, However, the effect of lncRNA TCONS_00019174 on antidepressant responses has not been investigated...
October 13, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29035800/exploring-mechanisms-of-change-in-schema-therapy-for-chronic-depression
#4
Fritz Renner, Robert DeRubeis, Arnoud Arntz, Frenk Peeters, Jill Lobbestael, Marcus J H Huibers
BACKGROUND AND OBJECTIVES: The underlying mechanisms of symptom change in schema therapy (ST) for chronic major depressive disorder (cMDD) have not been studied. The aim of this study was to explore the impact of two potentially important mechanisms of symptom change, maladaptive schemas (proxied by negative idiosyncratic core-beliefs) and the therapeutic alliance. METHODS: We drew data from a single-case series of ST for cMDD. Patients with cMDD (N = 20) received on average 78 repeated weekly assessments over a course of up to 65 individual sessions of ST...
October 6, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29035730/features-of-mood-associated-with-high-body-weight-in-females-with-fibromyalgia
#5
Alessandra Alciati, Fabiola Atzeni, Massimiliano Grassi, Daniela Caldirola, Piercarlo Sarzi-Puttini, Jules Angst, Giampaolo Perna
BACKGROUND: Fibromyalgia (FM) is a common syndrome whose main characteristic is chronic widespread musculoskeletal pain, the severity of which is frequently worsened by concomitant obesity. Major depression (MD), particularly as part of a bipolar spectrum disorder (BSD), is associated with both obesity and FM. OBJECTIVE: To evaluate the relationship between lifetime MD, hypomanic symptoms and the body mass index (BMI) in patients with FM. METHOD: Of the 115 patients originally screened, 87 women with FM finally entered the study...
September 6, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29035706/serious-suicide-attempts-in-outpatients-with-multiple-substance-use-disorders
#6
R Icick, E Karsinti, J-P Lépine, V Bloch, G Brousse, F Bellivier, F Vorspan
BACKGROUND: Suicide is a major public health concern and suicide attempts (SA) are frequent and burdensome in people suffering from substance use disorders (SUDs). In particular, serious SAs are a preoccupying form of attempt, which remain largely overlooked in these populations, especially regarding basic risk factors such as gender, addictive comorbidity and substance use patterns. Thus, we undertook a gender-specific approach to identify the risk factors for serious SAs in outpatients with multiple SUDs...
September 23, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29035144/risk-factors-for-multiple-suicide-attempts-among-roma-in-hungary
#7
Mónika Ditta Tóth, Szilvia Ádám, Tamás Zonda, Emma Birkás, György Purebl
In recent years, suicide rates in Hungary have been among the highest in the European Union. Attempted suicide rates in the Roma population are 2-3 times higher than in the non-Roma population. Since individuals making multiple attempts have a higher pro-bability of eventual death by suicide, and there are limited data on suicidal behaviour of the Roma population, the aim of this study was to explore the sociodemographic and psychological background factors of multiple suicide attempts in the Hungarian Roma population...
January 1, 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29034101/lamotrigine-induced-sexual-dysfunction-and-non-adherence-case-analysis-with-literature-review
#8
Kenneth R Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas
BACKGROUND: Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED treatment is adherence. Non-adherence is often related to severity of AEs. Frequently, patients do not spontaneously report, and clinicians do not specifically query, critical AEs that lead to non-adherence, including sexual dysfunction. Sexual dysfunction prevalence in patients with epilepsy ranges from 40 to 70%, often related to AEDs, epilepsy or mood states...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/29033054/temporary-stages-and-motivational-variables-two-complementary-perspectives-in-the-help-seeking-process-for-mental-disorders
#9
Gema Del Valle Del Valle, Carmen Carrió, Amparo Belloch
INTRODUCTION: Help-seeking for mental disorders is a complex process, which includes different temporary stages, and in which the motivational variables play an especially relevant role. However, there is a lack of instruments to evaluate in depth both the temporary and motivational variables involved in the help-seeking process. This study aims to analyse in detail these two sets of variables, using a specific instrument designed for the purpose, to gain a better understanding of the process of treatment seeking...
October 9, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29032046/past-present-and-future-of-genetic-research-in-borderline-personality-disorder
#10
REVIEW
Anahita Bassir Nia, Matthew C Eveleth, Jonathan M Gabbay, Yonis J Hassan, Bosi Zhang, M Mercedes Perez-Rodriguez
Borderline Personality Disorder (BPD) is a major mental illness with a lifetime prevalence of approximately 1-3%, characterized by a persistent pattern of instability in relationships, mood, impulse regulation, and sense of self. This results in impulsive self-damaging behavior, high suicide rates, and severe functional impairment. BPD has a complex, multifactorial etiology, resulting from an interaction among genetic and environmental substrates, and has moderate to high heritability based on twin and family studies...
September 12, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29031186/family-functioning-as-perceived-by-parents-and-young-offspring-at-high-and-low-risk-for-depression
#11
Shimrit Daches, Vera Vine, Kathryn M Layendecker, Charles J George, Maria Kovacs
BACKGROUND: Family dysfunction has been proposed as one of the environmental mechanisms whereby risk of depression is transmitted from mothers to their children. Using our sample of offspring at high and low familial risk for depression, we hypothesized that: a) high-risk offspring (n = 79) and their mothers will report more extensive family dysfunction than low-risk offspring (n = 82) and their mothers, b) family dysfunction will predict the extent of offspring's depressive symptoms, and c) family dysfunction will mediate the impact of mother's depression on offspring's depressive symptoms...
September 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29029678/positive-and-negative-affect-as-links-between-social-anxiety-and-depression-predicting-concurrent-and-prospective-mood-symptoms-in-unipolar-and-bipolar-mood-disorders
#12
Jonah N Cohen, M Taylor Dryman, Amanda S Morrison, Kirsten E Gilbert, Richard G Heimberg, June Gruber
The co-occurrence of social anxiety and depression is associated with increased functional impairment and a more severe course of illness. Social anxiety disorder is unique among the anxiety disorders in sharing an affective profile with depression, characterized by low levels of positive affect (PA) and high levels of negative affect (NA). Yet it remains unclear how this shared affective profile contributes to the covariation of social anxiety and depressive symptoms. We examined whether self-reported PA and NA accounted for unique variance in the association between social anxiety and depressive symptoms across three groups (individuals with remitted bipolar disorder, type I [BD; n = 32], individuals with remitted major depressive disorder [MDD; n = 31], and nonpsychiatric controls [n = 30]) at baseline and follow-ups of 6 and 12 months...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29027838/the-role-of-appraisal-in-dysphoric-affect-reactivity-to-positive-laboratory-films-and-daily-life-events-in-depression
#13
Vanessa Panaite, Alana Whittington, Alexandra Cowden Hindash
Hedonic deficits are linked to protracted dysphoric affect (DA) in depression, a disorder characterised by emotion context insensitivity (ECI). Recent findings from daily life studies contradict the ECI view. This study longitudinally investigated DA across laboratory and daily life contexts and the conditions associated with discrepancies in DA reactivity. Thirty-three healthy controls and 41 adults with major depressive disorder (MDD) provided responses to neutral and positive (a) films viewed in the laboratory and (b) daily events recorded over the course of three days using ecological momentary assessment (EMA) methodology...
October 13, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/29022126/a-systematic-review-of-cortisol-thyroid-stimulating-hormone-and-prolactin-in-peripartum-women-with-major-depression
#14
REVIEW
Mercedes J Szpunar, Barbara L Parry
Pregnancy and postpartum are periods of high susceptibility to major depression (MD) and other mood disorders. The peripartum period is also a time of considerable changes in the levels of hormones, including cortisol, thyroid-stimulating hormone (TSH), prolactin, gonadotropins, and gonadal steroids. To investigate the relationship between mood and hormonal changes during and after pregnancy, we reviewed published reports of hormonal measures during this time frame, searched via PubMed and Web of Science. Studies were included if women in the antepartum or postpartum periods were clinically diagnosed with MD, and if there were repeated measures of cortisol, TSH, or prolactin...
October 11, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29021832/pharmacogenomics-in-the-treatment-of-mood-disorders-strategies-and-opportunities-for-personalized-psychiatry
#15
REVIEW
Azmeraw T Amare, Klaus Oliver Schubert, Bernhard T Baune
Personalized medicine (personalized psychiatry in a specific setting) is a new model towards individualized care, in which knowledge from genomics and other omic pillars (microbiome, epigenomes, proteome, and metabolome) will be combined with clinical data to guide efforts to new drug development and targeted prescription of the existing treatment options. In this review, we summarize pharmacogenomic studies in mood disorders that may lay the foundation towards personalized psychiatry. In addition, we have discussed the possible strategies to integrate data from omic pillars as a future path to personalized psychiatry...
September 2017: EPMA Journal
https://www.readbyqxmd.com/read/29017334/brexpiprazole-a-new-leaf-on-the-partial-dopamine-agonist-branch
#16
Judy Hope, David Castle, Nicholas A Keks
OBJECTIVES: Brexpiprazole is a new dopamine partial agonist antipsychotic in the same class as aripiprazole. This paper will briefly review brexpiprazole and compare it with aripiprazole. CONCLUSIONS: Brexpiprazole and aripiprazole are both partial agonists at dopamine D2, and serotonin 5-HT1A and antagonists at serotonin 5-HT2A and noradrenergic α1B receptors. However, the two drugs are significantly different in potencies at various receptors; neurochemical profiles predict that brexpiprazole may be comparable with aripiprazole in its antipsychotic efficacy but may cause less akathisia, extrapyramidal side effects (EPS) and activation...
October 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28993835/delta-opioid-receptors-and-modulation-of-mood-and-emotion
#17
Isaac J Dripps, Emily M Jutkiewicz
Depression is a pervasive and debilitating mental disorder that is inadequately treated by current pharmacotherapies in a majority of patients. Although opioids have long been known to regulate mood states, the use of opioids to treat depression is rarely discussed. This chapter explores the preclinical and clinical evidence supporting the antidepressant-like effects of opioid ligands, and in particular, delta opioid receptor (DOR) agonists. DOR agonists have been shown to produce antidepressant-like effects in a number of animal models...
October 10, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28992897/inflammatory-bowel-disease-and-eating-disorders-a-systematized-review-of-comorbidity
#18
REVIEW
L Ilzarbe, M Fàbrega, R Quintero, A Bastidas, L Pintor, J García-Campayo, F Gomollón, D Ilzarbe
OBJECTIVE: Research has shown that there is an association between Inflammatory Bowel Disease, anxiety and mood disorders, however little is known about their association with Eating Disorders. In this paper we will present a case of a young female with a comorbid diagnosis of Inflammatory Bowel Disease and Eating Disorder, and then discuss the results from a systematic review of the literature, describing published cases of patients with the same condition. METHODS: A systematized review of the literature was conducted according to MOOSE guidelines...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28987512/genes-linking-mitochondrial-function-cognitive-impairment-and-depression-are-associated-with-endophenotypes-serving-precision-medicine
#19
Peter Petschner, Xenia Gonda, Daniel Baksa, Nora Eszlari, Michael Trivaks, Gabriella Juhasz, Gyorgy Bagdy
Mitochondria densely populate cells in central nervous system providing essential energy for neurons and influencing synaptic plasticity. Harm to these organelles can impair cognitive performance through damaged neurotransmission and altered Ca(2+) homeostasis. Impaired cognition could be one underlying factor which can characterize major depressive disorder, a huge burden for society marked by depressed mood and anhedonia. A growing body of evidence binds mitochondrial dysfunctions with the disease. Cognitive disturbances with different severity are also observable in several patients, suggesting that damage or inherited alterations of mitochondria may have an important role in depression...
October 5, 2017: Neuroscience
https://www.readbyqxmd.com/read/28986865/nmda-receptors-in-the-central-nervous-system
#20
Kasper B Hansen, Feng Yi, Riley E Perszyk, Frank S Menniti, Stephen F Traynelis
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major component of excitatory neurotransmission in the central nervous system (CNS). They are widely distributed at all stages of development and are critically involved in normal brain functions, including neuronal development and synaptic plasticity. NMDA receptors are also implicated in the pathophysiology of numerous neurological and psychiatric disorders, such as ischemic stroke, traumatic brain injury, Alzheimer's disease, epilepsy, mood disorders, and schizophrenia...
2017: Methods in Molecular Biology
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