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https://www.readbyqxmd.com/read/27887611/the-performance-of-interferon-gamma-release-assay-in-nontuberculous-mycobacterial-diseases-a-retrospective-study-in-china
#1
Mao-Shui Wang, Jun-Li Wang, Xin-Feng Wang
BACKGROUND: The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study to evaluate the performance of the T-SPOT.TB in patients with NTM diseases. METHODS: Between March, 2013 and Nov, 2015, a total of 58 patients with NTM diseases had a T-SPOT.TB performed were enrolled, 30 patients had definite NTM diseases, 28 had probable diseases...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27865239/patterns-of-granulomatous-responses-in-tb-lymphadenitis-and-their-correlation-with-treatment-outcomes
#2
Debarshi Saha, Komal Rautela, Ashwani Kumar, Pooja K Suresh
INTRODUCTION: Four patterns are noted in aspirates of TB lymphadenitis with or without concomitant HIV. They are granulomatous, necrotizing granulomatous, predominantly necrotizing and necrotizing suppurative designated pattern 1, 2, 3 and 4, respectively. The present study attempted to correlate granulomatous patterns, Acid Fast Bacilli (AFB) density with treatment outcomes. MATERIALS AND METHODS: The MGG and Papanicolaou stained slides of 56 lymphadenitis patients, 38 TB and 18 TB with seropositive HIV were studied for two years...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27863623/tuberculous-lymphadenitis-of-the-head-and-neck-in-canadian-children-experience-from-a-low-burden-region
#3
Jason J Xu, Shazia Peer, Blake C Papsin, Ian Kitai, Evan J Propst
BACKGROUND: Children are more likely than adults to develop extra-pulmonary tuberculosis (EPTB), which often presents as cervical lymphadenopathy. The role of surgery in management is uncertain. We reviewed all head and neck EPTB cases presenting to our tertiary care pediatric institution over a twelve-year period. METHODS: All children 18 years of age and younger with EPTB involving the head and neck were included. We recorded clinical data and age at diagnosis, birth country, BCG vaccination status, as well as radiographic, surgical, histological, and microbiological results...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27797813/hoarse-voice-a-rare-presentation-of-tuberculosis-lymphadenitis
#4
Laurie Rigueros Springford, Krishan Ramdoo, Dilip Nair, Ali Taghi
A man aged 37 years from Indian descent presented to an inner city London hospital with hoarseness of voice, fatigue, night sweats and a 2 kg weight loss. Laryngoscopy demonstrated a left vocal fold palsy. Extensive investigations were undertaken with disseminated malignancy being primarily investigated. CT/MRI scanning showed non-specific necrotic mediastinal lymph nodes. Tuberculin skin testing, cytology and PCR were eventually undergone. Tests yielded results consistent with tuberculosis (TB) infection and the patient was started on standard TB treatment protocol, with excellent results...
October 24, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27794266/reduced-systemic-and-mycobacterial-antigen-stimulated-concentrations-of-il-1%C3%AE-and-il-18-in-tuberculous-lymphadenitis
#5
Gokul Raj Kathamuthu, Kadar Moideen, Dhanaraj Bhaskaran, Gomathi Sekar, Rathinam Sridhar, Bharathi Vidyajayanthi, Ganeshan Gajendraraj, Subash Babu
BACKGROUND: Type 1, Type 17 and other pro-inflammatory cytokines are known to play an important role in resistance to pulmonary tuberculosis. The role of these cytokines in tuberculous lymphadenitis (TBL) is not well characterized. METHODS: To estimate the systemic and mycobacterial antigen - stimulated cytokine concentrations of Type 1, Type 17, other pro-inflammatory and regulatory cytokines in TBL, we examined both the systemic and the antigen-specific concentrations of these cytokines in TBL (n=31) before and after chemotherapy, and compared them with those with latent tuberculosis infection (LTB, n=31)...
October 26, 2016: Cytokine
https://www.readbyqxmd.com/read/27776596/molecular-typing-of-mycobacteria-isolated-from-tuberculous-lymphadenitis-cases-in-addis-ababa-ethiopia
#6
O Zewdie, A Mihret, G Ameni, A Worku, T Gemechu, T Abebe
BACKGROUND: In Ethiopia, one of the world's 22 high tuberculosis (TB) burden countries, one third of the tuberculosis (TB) cases are attributed to tuberculosis lymphadenitis (TBLN). However, information on the molecular type of the mycobacterial species and strains that cause TBLN in the country is scarce. OBJECTIVE: To identify the species and strains of mycobacteria that cause TBLN in Ethiopia. METHODS AND RESULTS: A cross-sectional study was conducted among 206 presumed TBLN cases to characterise positive culture isolates...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27766918/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-rinse-fluid-polymerase-chain-reaction-in-the-diagnosis-of-intrathoracic-tuberculous-lymphadenitis
#7
Viboon Boonsarngsuk, Siriwan Saengsri, Pitak Santanirand
BACKGROUND: Intrathoracic tuberculous (TB) lymphadenitis is a diagnostic challenge to the clinician. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can obtain a sample from the affected lymph node, the diagnosis of TB lymphadenitis by cytopathology remains inaccurate. OBJECTIVE: To evaluate the efficacy of EBUS-TBNA rinse fluid TB polymerase chain reaction (PCR) assay for the diagnosis of intrathoracic TB lymphadenitis. METHODS: A retrospective study was conducted on 102 patients who underwent EBUS-TBNA for diagnostic evaluation of intrathoracic lymphadenopathy...
October 21, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27762524/multifocal-tuberculosis
#8
Reeta James, S Avudaiappan, A Assistant Professor, Kumar Natarajan, S Chandrasekaran
Multifocal Tuberculosis represents the many faces of an age old disease. It is characterized by the presence of large multifocal tuberculous areas in same or different organs. A 50 year old male patient, presented with features suggestive of renal failure, low grade fever and cough with mucoid expectoration. He was found to have pulmonary TB, genitourinary TB and tuberculous lymphadenitis. He was started on antituberculous treatment to which he showed good response.
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27752009/prevalence-and-presentation-of-tuberculosis-among-hemodialysis-patients-in-khartoum-sudan
#9
Amin S I Banaga, Nihad K Siddiq, Randa T Alsayed, Rasha Babiker, Khalifa Elmusharaf
Tuberculosis (TB) is a major health problem in the developing countries. There are limited data about the prevalence of TB patients on maintenance hemodialysis (HD) in Sudan. The aim of this study is to identify the prevalence and presentation of TB among Sudanese maintenance HD patients. This is a hospital-based descriptive study. The participants of the study are all HD patients distributed in 13 HD centers in Khartoum and Khartoum North Provinces in Sudan. All patients attended the HD centers from November 1, 2014 to February 1, 2015, were interviewed by a questionnaire focused on personal and clinical data...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27749923/differential-adverse-event-profiles-associated-with-bcg-as-a-preventive-tuberculosis-vaccine-or-therapeutic-bladder-cancer-vaccine-identified-by-comparative-ontology-based-vaers-and-literature-meta-analysis
#10
Jiangan Xie, Christopher Codd, Kevin Mo, Yongqun He
M. bovis strain Bacillus Calmette-Guérin (BCG) has been the only licensed live attenuated vaccine against tuberculosis (TB) for nearly one century and has also been approved as a therapeutic vaccine for bladder cancer treatment since 1990. During its long time usage, different adverse events (AEs) have been reported. However, the AEs associated with the BCG preventive TB vaccine and therapeutic cancer vaccine have not been systematically compared. In this study, we systematically collected various BCG AE data mined from the US VAERS database and PubMed literature reports, identified statistically significant BCG-associated AEs, and ontologically classified and compared these AEs related to these two types of BCG vaccine...
2016: PloS One
https://www.readbyqxmd.com/read/27746818/tuberculous-lymphadenitis-mimicking-nodal-metastasis-in-follicular-variant-papillary-thyroid-carcinoma
#11
Marc Gregory Yu, Jenny Maureen Atun
Tuberculous (TB) lymphadenitis can mimic cervical node metastasis from papillary thyroid carcinoma (PTC) since the distribution and appearance of affected lymph nodes are similar. We present the case of an asymptomatic 50-year-old Filipino who sought consult for a gradually enlarging anterior neck mass and a single palpable cervical lymph node. Preoperative workup suggested a thyroid malignancy with nodal metastasis. He underwent total thyroidectomy with node dissection where histopathology confirmed follicular variant- (FV-) PTC...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27686557/paratesticular-rhabdomyosarcoma-associated-with-tuberculosis
#12
Neriman Sarı, Nurettin Okur, Gulin Uçmak, İnci Ergürhan İlhan
We report a 16-year-old male patient diagnosed with paratesticular rhabdomyosarcoma and mediastinal tuberculous lymphadenitis. The differential diagnosis between high or early stage of rhabdomyosarcoma and tuberculosis (TB) was critical in this patient without a history of TB. Unexpected lymphadenopathies detected during the staging of patients with malignancy should be carefully evaluated, and TB should be taken into consideration in the differential diagnosis especially in underdeveloped and developing countries...
September 28, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27649674/disseminated-bacille-calmette-gu%C3%A3-rin-disease-in-saudi-children-clinical-profile-microbiology-immunology-evaluation-and-outcome
#13
E Bukhari, F Alaklobi, H Bakheet, A Alrabiaah, F Alotibi, F Aljobair, M Alshamrani, E Alaki, F Alnahdi, A Alodyani, F Alzamil
OBJECTIVE: The bacille Calmette Guérin (BCG) vaccine is administered worldwide to prevent tuberculosis. Although, Post BCG vaccination complications like disseminated BCG infections are rare and immunocompromised children are at high risk of developing BCG-related complications including BCG-lymphadenitis and other disseminated diseases. PATIENTS AND METHODS: This was a prospective study of children who developed disseminated BCG after vaccination who were admitted in three tertiary care hospital in Riyadh, Saudi Arabia, in the year 2015...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27600661/determinants-of-treatment-related-paradoxical-reactions-during-anti-tuberculosis-therapy-a-case-control-study
#14
Colin Stewart Brown, Colette Joanne Smith, Ronan Angus MacCormick Breen, Lawrence Peter Ormerod, Rahul Mittal, Marie Fisk, Heather June Milburn, Nicholas Martin Price, Graham Henry Bothamley, Marc Caeroos Isaac Lipman
BACKGROUND: Inflammatory response following initial improvement with anti-tuberculosis (TB) treatment has been termed a paradoxical reaction (PR). HIV co-infection is a recognised risk, yet little is known about other predictors of PR, although some biochemical markers have appeared predictive. We report our findings in an ethnically diverse population of HIV-infected and uninfected adults. METHODS: Prospective and retrospective clinical and laboratory data were collected on TB patients seen between January 1999-December 2008 at four UK centres selected to represent a wide ethnic and socio-economic mix of TB patients...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27563340/tuberculous-lymphadenitis-comparison-of-cytomorphology-ziehl-neelsen-staining-and-rapid-mycobacterial-culture-at-a-pediatric-superspecialty-hospital
#15
Sonam Mahana, Reena Tomar, Rawi Agrawal, Rushika Saksena, Vikas Manchanda, Ruchika Gupta
BACKGROUND: To evaluate and compare the role of Ziehl-Neelsen (ZN) staining and mycobacterial culture in diagnosis of tuberculous lymphadenitis. MATERIALS AND METHODS: A total of 56 fine needle aspirations (FNAs) from patients who were clinically suspected to have tuberculous lymphadenitis were included. Acid-fast Bacilli detection was attempted by ZN staining on smears as well as culture on Middlebrook 7H9 broth. Percentage positivity of both smears and culture was calculated...
2016: CytoJournal
https://www.readbyqxmd.com/read/27411409/pediatric-tuberculosis-in-turkey-a-review-of-8-years-period-in-a-tertiary-care-hospital
#16
Gülsüm İclal Bayhan, Gönül Tanır, Özge Metin, Hülya Şimsek, Türkan Aydın Teke, Fatma Nur Öz, Zeynep Gökçe Gayretli Aydın
The purpose of this study was to evaluate the clinical, radiological, microbiological characteristics, side effects of anti-TB drugs and treatment outcome of childhood definite or probable TB. The medical records of all childhood TB patients were investigated in the department of pediatric infectious disease of a tertiary care hospital between January 2005 and December 2012. Patients who followed-up until the anti-TB treatment was completed were included in the study. One hundred forty four pediatric cases with active TB were included in the study (27 definite, 117 probable)...
September 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27375699/cervical-tuberculous-lymphadenitis-clinico-demographic-profiles-of-patients-in-a-secondary-level-hospital-of-bangladesh
#17
Mohammad Shah Kamal, Md Hafiz Ehsanul Hoque, Fazle Rabbi Chowdhury, Rubina Farzana
OBJECTIVE: Tuberculosis (TB) is a major public health problem in Bangladesh since long. The present incidence and prevalence rates of all forms of TB are 227 and 404/100,000 population respectively. The aim of this study was to find out the clinical characteristics of involved cervical lymph nodes, demographic characteristics of the patients and response to treatment of Cervical Tuberculous Lymphadenitis (CTL) cases. METHODS: A prospective study was performed in Shaheed Shamsuddin Ahmed Hospital, Sylhet, Bangladesh from June 2012 to June 2014...
May 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27277378/a-patient-with-grave-s-disease-and-tuberculous-lymphadenitis
#18
M F Rahaman, M H Chowdhury, A H Khan, M Rahman, T K Barman, M J Chowdhury
Immune reactivity between Mycobacteria and human antigens can play an important role in the pathogenesis of autoimmune disease. We report a case of Graves's disease and tuberculous lymphadenitis to explain the mechanism of correlation between immune-mediated diseases and tuberculosis and to raise awareness of the importance of screening for TB in this context, especially in endemic country. Screening for latent TB at immune mediated disease diagnosis and regular timely screening thereafter may be beneficial...
April 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27268404/evaluation-of-xpert%C3%A2-mtb-rif-and-ustar-easynat%C3%A2-tb-iad-for-diagnosis-of-tuberculous-lymphadenitis-of-children-in-tanzania-a-prospective-descriptive-study
#19
Maira Bholla, Neema Kapalata, Edward Masika, Hassan Chande, Levan Jugheli, Mohamed Sasamalo, Tracy R Glass, Hans-Peter Beck, Klaus Reither
BACKGROUND: Fine needle aspiration biopsy has become a standard approach for diagnosis of peripheral tuberculous lymphadenitis. The aim of this study was to compare the performance of Xpert MTB/RIF and Ustar EasyNAT TB IAD nucleic acid amplification assays, against acid-fast bacilli microscopy, cytology and mycobacterial culture for the diagnosis of TB lymphadenitis in children from a TB-endemic setting in Tanzania. METHODS: Children of 8 weeks to 16 years of age, suspected of having TB lymphadenitis, were recruited at a district hospital in Tanzania...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27264431/a-case-of-abdominal-tuberculosis-lymphadenitis-extending-into-the-gallbladder-and-duodenum-in-a-human-t-cell-lymphotropic-virus-type-1-carrier
#20
Hitoshi Mabuchi, Masaru Miyazato, Shuichi Maruwaka, Yuzuru Kinjo, Noriya Nakachi, Ryosaku Tomiyama, Hiroto Shimajiri, Hirofumi Tomori
A 69-year-old man with a history of pulmonary tuberculosis presented with fever. He tested positive for the QuantiFERON TB-2G and human T-cell lymphotropic virus type 1 antibodies. Imaging revealed a mass in the neck of the gallbladder, with periportal lymph node enlargement and penetration into the duodenum. A definite diagnosis could not be made, even with a subsequent detailed examination. Finally, cholecystectomy and a lymph node biopsy were performed. Histopathology revealed a caseating granuloma in the lymph nodes and in the serosa of the gallbladder, and polymerase chain reaction was positive for tuberculosis...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
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