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https://www.readbyqxmd.com/read/28425207/bcg-vaccination-induced-suppurative-lymphadenitis-four-signs-to-pay-attention-to
#1
Sang Oon Baek, Hyo Sun Ko, Hyun Ho Han
Suppurative lymphadenitis is one of the severe complication after BCG vaccination, but its diagnostic criteria and treatment guidelines have not yet been established. In this article, we describe a case of suppurative lymphadenitis caused by BCG vaccination and propose diagnostic criteria and treatment guidelines of the disease. The lymphadenitis was presented as skin involving mass and was completely extirpated. Pathological evaluation revealed a necrotising lymphadenitis, consistent with the diagnosis of BCG lymphadenitis...
April 19, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28413722/performance-of-interferon-%C3%AE-release-assay-in-the-diagnosis-of-tuberculous-lymphadenitis-a-meta-analysis
#2
Qianqian Liu, Wenzhang Li, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Binmiao Liang, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
BACKGROUND: The diagnostic values of interferon-gamma release assays (IGRA) in tuberculosis (TB) vary a lot with different site of infections, with especially higher sensitivities in chronic forms of TB such as tuberculosis of the lymph node. We conducted a meta-analysis to comprehensively evaluate the overall accuracy of diagnostic IGRA for tuberculous lymphadenitis. METHODS: Pubmed, Web of Science, EMBASE, Wanfang and CNKI databases up to February 17, 2017 were searched to identify published studies...
2017: PeerJ
https://www.readbyqxmd.com/read/28372894/the-additional-role-of-xpert-mtb-rif-in-the-diagnosis-of-intrathoracic-tuberculous-lymphadenitis
#3
Jinwoo Lee, Sun Mi Choi, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
BACKGROUND: Diagnosis of intrathoracic tuberculosis (TB) lymphadenitis remains a challenge because of difficulties in obtaining adequate tissue and the lack of a sensitive test. Recently, Xpert MTB/RIF assay is being used for rapid diagnosis of pulmonary TB, but it has not yet been widely validated in intrathoracic TB lymphadenitis. The aim of this study was to assess the additional role of Xpert MTB/RIF in diagnosing intrathoracic TB lymphadenitis using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimen...
March 31, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28284263/immune-thrombocytopenia-secondary-to-tuberculosis-a-case-and-review-of-literature
#4
S F Weber, S Bélard, S Rai, R Reddy, S Belurkar, K Saravu
Immune thrombocytopenia (ITP) is an auto-immune condition that results in isolated thrombocytopenia associated with possibly lethal haemorrhage. In its secondary form, ITP can be triggered by many infectious and non-infectious conditions. Secondary ITP associated with tuberculosis (TB) has rarely been described in the literature. We report on a 22-year-old patient presenting with hypermenorrhoea and petechiae due to ITP secondary to tuberculous lymphadenitis. Normalisation of thrombocytopenia was only achieved after initiation of anti-tuberculosis treatment following failure of thrombocyte substitution and immune-modulatory treatment...
April 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28249842/tb-lymphadenitis-is-associated-with-enhanced-baseline-and-antigen-specific-induction-of-type-1-and-type-17-cytokines-and-reduced-il-1%C3%AE-and-il-18-at-the-site-of-infection
#5
Gokul Raj Kathamuthu, Kadar Moideen, Dhanaraj Baskaran, Vaithilingam V Banurekha, Dina Nair, Gomathi Sekar, Rathinam Sridhar, Bharathi Vidyajayanthi, Ganeshan Gajendraraj, Dinesh Kumar Parandhaman, Alena Srinivasan, Subash Babu
Tuberculous lymphadenitis (TBL) is characterized by an expansion of Th1 and Th17 cells with altered serum levels of pro-inflammatory cytokines. However, the cytokine profile at the site of infection i.e. the affected lymph nodes, has not been examined in detail. To estimate the baseline and mycobacterial antigen - stimulated cytokine concentrations of Type 1, Type 17 and other pro-inflammatory cytokines in TBL, we examined both the baseline and the antigen - specific concentrations of these cytokines in TBL (n = 14) before and after chemotherapy and compared them with pulmonary tuberculosis infection (PTB, n = 14)...
March 1, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28161459/peptide-microarray-based-characterization-of-antibody-responses-to-host-proteins-after-bacille-calmette-gu%C3%A3-rin-vaccination
#6
REVIEW
Davide Valentini, Martin Rao, Lalit Rane, Sayma Rahman, Rebecca Axelsson-Robertson, Rainer Heuchel, Matthias Löhr, Daniel Hoft, Susanna Brighenti, Alimuddin Zumla, Markus Maeurer
BACKGROUND: Bacille Calmette-Guérin (BCG) is the world's most widely distributed vaccine, used against tuberculosis (TB), in cancer immunotherapy, and in autoimmune diseases due to its immunomodulatory properties. To date, the effect of BCG vaccination on antibody responses to host proteins has not been reported. High-content peptide microarrays (HCPM) offer a unique opportunity to gauge specific humoral immune responses. METHODS: The sera of BCG-vaccinated healthy adults were tested on a human HCPM platform (4953 randomly selected epitopes of human proteins) to detect specific immunoglobulin gamma (IgG) responses...
February 2, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28104935/neurotuberculosis-immune-reconstitution-inflammatory-syndrome-in-the-setting-of-hiv-infection-a-case-report-and-review-of-literature
#7
Deepasree Jaganmohan, Sunitha V Chakkalakkoombil, Anjana A Beena, Nagarajan Krishnan
Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated immune response which can occur with various coinfections in human immunodeficiency virus (HIV) infected patients, of which the most commonly implicated in central nervous system (CNS)-IRIS are progressive multifocal leukoencephalopathy (PML), cryptococcosis, and tuberculosis (TB). TB-IRIS is a known complication of pulmonary TB or TB lymphadenitis coinfection in HIV infected patients who are on antituberculosis treatment (ATT) after the initiation of antiretroviral therapy (ART)...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28061860/preliminary-investigation-of-the-transmission-of-tuberculosis-between-farmers-and-their-cattle-in-smallholder-farms-in-northwestern-ethiopia-a-cross-sectional-study
#8
Anwar Nuru, Gezahegne Mamo, Aboma Zewude, Yitayal Mulat, Gashaw Yitayew, Aschalew Admasu, Girmay Medhin, Rembert Pieper, Gobena Ameni
BACKGROUND: The feeding habits and close physical contact between Ethiopian farmers and their cattle promote the transmission of tuberculosis (TB) between the farmers and their cattle. This study aimed to investigate the transmission of TB between farmers and their cattle in smallholder farms in northwestern Ethiopia. RESULTS: A total of 70 human TB lymphadenitis (TBLN) cases visiting the Felegehiwot Comprehensive Specialized Hospital in Bahir Dar City and 660 cattle were investigated...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28052948/tb-or-not-to-be-kikuchi-fujimoto-disease-a-rare-but-important-differential-for-tb
#9
C McKenna, T Whitfield, N Patel, A Bonington
A 29-year-old British Pakistani woman presented with a 2-month history of drenching fevers, night sweats, lethargy and tender cervical and axillary lymphadenopathy. Initial investigations, bloods and imaging were unremarkable. Fever persisted during her admission, and treatment for tuberculosis (TB) lymphadenitis was started postbiopsy until histology confirmed a diagnosis of Kikuchi-Fujimoto's disease (KFD). KFD has a non-specific presentation of fever, night sweats and lymphadenopathy and commonly raises a clinical suspicion of a number of other serious conditions such as TB, lymphoma, HIV, systemic lupus erythematous, toxoplasmosis and infectious mononucleosis...
January 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/27887611/the-performance-of-interferon-gamma-release-assay-in-nontuberculous-mycobacterial-diseases-a-retrospective-study-in-china
#10
Mao-Shui Wang, Jun-Li Wang, Xin-Feng Wang
BACKGROUND: The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study to evaluate the performance of the T-SPOT.TB in patients with NTM diseases. METHODS: Between March, 2013 and Nov, 2015, a total of 58 patients with NTM diseases had a T-SPOT.TB performed were enrolled, 30 patients had definite NTM diseases, 28 had probable diseases...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27865239/patterns-of-granulomatous-responses-in-tb-lymphadenitis-and-their-correlation-with-treatment-outcomes
#11
Debarshi Saha, Komal Rautela, Ashwani Kumar, Pooja K Suresh
INTRODUCTION: Four patterns are noted in aspirates of TB lymphadenitis with or without concomitant HIV. They are granulomatous, necrotizing granulomatous, predominantly necrotizing and necrotizing suppurative designated pattern 1, 2, 3 and 4, respectively. The present study attempted to correlate granulomatous patterns, Acid Fast Bacilli (AFB) density with treatment outcomes. MATERIALS AND METHODS: The MGG and Papanicolaou stained slides of 56 lymphadenitis patients, 38 TB and 18 TB with seropositive HIV were studied for two years...
July 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27863623/tuberculous-lymphadenitis-of-the-head-and-neck-in-canadian-children-experience-from-a-low-burden-region
#12
Jason J Xu, Shazia Peer, Blake C Papsin, Ian Kitai, Evan J Propst
BACKGROUND: Children are more likely than adults to develop extra-pulmonary tuberculosis (EPTB), which often presents as cervical lymphadenopathy. The role of surgery in management is uncertain. We reviewed all head and neck EPTB cases presenting to our tertiary care pediatric institution over a twelve-year period. METHODS: All children 18 years of age and younger with EPTB involving the head and neck were included. We recorded clinical data and age at diagnosis, birth country, BCG vaccination status, as well as radiographic, surgical, histological, and microbiological results...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27797813/hoarse-voice-a-rare-presentation-of-tuberculosis-lymphadenitis
#13
Laurie Rigueros Springford, Krishan Ramdoo, Dilip Nair, Ali Taghi
A man aged 37 years from Indian descent presented to an inner city London hospital with hoarseness of voice, fatigue, night sweats and a 2 kg weight loss. Laryngoscopy demonstrated a left vocal fold palsy. Extensive investigations were undertaken with disseminated malignancy being primarily investigated. CT/MRI scanning showed non-specific necrotic mediastinal lymph nodes. Tuberculin skin testing, cytology and PCR were eventually undergone. Tests yielded results consistent with tuberculosis (TB) infection and the patient was started on standard TB treatment protocol, with excellent results...
October 24, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27794266/reduced-systemic-and-mycobacterial-antigen-stimulated-concentrations-of-il-1%C3%AE-and-il-18-in-tuberculous-lymphadenitis
#14
Gokul Raj Kathamuthu, Kadar Moideen, Dhanaraj Bhaskaran, Gomathi Sekar, Rathinam Sridhar, Bharathi Vidyajayanthi, Ganeshan Gajendraraj, Subash Babu
BACKGROUND: Type 1, Type 17 and other pro-inflammatory cytokines are known to play an important role in resistance to pulmonary tuberculosis. The role of these cytokines in tuberculous lymphadenitis (TBL) is not well characterized. METHODS: To estimate the systemic and mycobacterial antigen - stimulated cytokine concentrations of Type 1, Type 17, other pro-inflammatory and regulatory cytokines in TBL, we examined both the systemic and the antigen-specific concentrations of these cytokines in TBL (n=31) before and after chemotherapy, and compared them with those with latent tuberculosis infection (LTB, n=31)...
February 2017: Cytokine
https://www.readbyqxmd.com/read/27776596/molecular-typing-of-mycobacteria-isolated-from-tuberculous-lymphadenitis-cases-in-addis-ababa-ethiopia
#15
O Zewdie, A Mihret, G Ameni, A Worku, T Gemechu, T Abebe
BACKGROUND: In Ethiopia, one of the world's 22 high tuberculosis (TB) burden countries, one third of the tuberculosis (TB) cases are attributed to tuberculosis lymphadenitis (TBLN). However, information on the molecular type of the mycobacterial species and strains that cause TBLN in the country is scarce. OBJECTIVE: To identify the species and strains of mycobacteria that cause TBLN in Ethiopia. METHODS AND RESULTS: A cross-sectional study was conducted among 206 presumed TBLN cases to characterise positive culture isolates...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27766918/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-rinse-fluid-polymerase-chain-reaction-in-the-diagnosis-of-intrathoracic-tuberculous-lymphadenitis
#16
Viboon Boonsarngsuk, Siriwan Saengsri, Pitak Santanirand
BACKGROUND: Intrathoracic tuberculous (TB) lymphadenitis is a diagnostic challenge to the clinician. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can obtain a sample from the affected lymph node, the diagnosis of TB lymphadenitis by cytopathology remains inaccurate. OBJECTIVE: To evaluate the efficacy of EBUS-TBNA rinse fluid TB polymerase chain reaction (PCR) assay for the diagnosis of intrathoracic TB lymphadenitis. METHODS: A retrospective study was conducted on 102 patients who underwent EBUS-TBNA for diagnostic evaluation of intrathoracic lymphadenopathy...
March 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27762524/multifocal-tuberculosis
#17
Reeta James, S Avudaiappan, A Assistant Professor, Kumar Natarajan, S Chandrasekaran
Multifocal Tuberculosis represents the many faces of an age old disease. It is characterized by the presence of large multifocal tuberculous areas in same or different organs. A 50 year old male patient, presented with features suggestive of renal failure, low grade fever and cough with mucoid expectoration. He was found to have pulmonary TB, genitourinary TB and tuberculous lymphadenitis. He was started on antituberculous treatment to which he showed good response.
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27752009/prevalence-and-presentation-of-tuberculosis-among-hemodialysis-patients-in-khartoum-sudan
#18
Amin S I Banaga, Nihad K Siddiq, Randa T Alsayed, Rasha Babiker, Khalifa Elmusharaf
Tuberculosis (TB) is a major health problem in the developing countries. There are limited data about the prevalence of TB patients on maintenance hemodialysis (HD) in Sudan. The aim of this study is to identify the prevalence and presentation of TB among Sudanese maintenance HD patients. This is a hospital-based descriptive study. The participants of the study are all HD patients distributed in 13 HD centers in Khartoum and Khartoum North Provinces in Sudan. All patients attended the HD centers from November 1, 2014 to February 1, 2015, were interviewed by a questionnaire focused on personal and clinical data...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27749923/differential-adverse-event-profiles-associated-with-bcg-as-a-preventive-tuberculosis-vaccine-or-therapeutic-bladder-cancer-vaccine-identified-by-comparative-ontology-based-vaers-and-literature-meta-analysis
#19
Jiangan Xie, Christopher Codd, Kevin Mo, Yongqun He
M. bovis strain Bacillus Calmette-Guérin (BCG) has been the only licensed live attenuated vaccine against tuberculosis (TB) for nearly one century and has also been approved as a therapeutic vaccine for bladder cancer treatment since 1990. During its long time usage, different adverse events (AEs) have been reported. However, the AEs associated with the BCG preventive TB vaccine and therapeutic cancer vaccine have not been systematically compared. In this study, we systematically collected various BCG AE data mined from the US VAERS database and PubMed literature reports, identified statistically significant BCG-associated AEs, and ontologically classified and compared these AEs related to these two types of BCG vaccine...
2016: PloS One
https://www.readbyqxmd.com/read/27746818/tuberculous-lymphadenitis-mimicking-nodal-metastasis-in-follicular-variant-papillary-thyroid-carcinoma
#20
Marc Gregory Yu, Jenny Maureen Atun
Tuberculous (TB) lymphadenitis can mimic cervical node metastasis from papillary thyroid carcinoma (PTC) since the distribution and appearance of affected lymph nodes are similar. We present the case of an asymptomatic 50-year-old Filipino who sought consult for a gradually enlarging anterior neck mass and a single palpable cervical lymph node. Preoperative workup suggested a thyroid malignancy with nodal metastasis. He underwent total thyroidectomy with node dissection where histopathology confirmed follicular variant- (FV-) PTC...
2016: Case Reports in Medicine
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