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https://www.readbyqxmd.com/read/29350615/chimeras-could-help-in-the-fight-against-leptospirosis
#1
Jademilson C Santos, Ana Lucia To Nascimento
Understanding the structure of an antigen can guide the design of improved antigen-based vaccines.
January 19, 2018: ELife
https://www.readbyqxmd.com/read/29349716/detection-of-bovine-carriers-of-leptospira-by-serological-bacteriological-and-molecular-tools
#2
Melissa H Pinna, Gabriel Martins, Ana Paula Loureiro, Walter Lilenbaum
Bovine leptospirosis is an important infectious disease that causes reproductive problems and economic risks, particularly in the tropics. The present study aimed to determine the extent of Leptospira infection among bovines on a slaughterhouse from Rio de Janeiro, Brazil via serological, bacteriological, and molecular tests. Two hundred eight bovines were examined in total, and we obtained 208 blood samples for serology, 198 urine samples collected via direct bladder puncture for polymerase chain reaction (PCR) and culture, 208 kidney samples (one from each animal) for PCR and culture, and 92 vaginal fluid samples from sterile swabs for PCR and culture...
January 18, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29340460/first-serologic-evidence-of-human-hantavirus-infection-in-alagoas-state-in-northeastern-brazil
#3
José Alfredo Dos Santos-Júnior, Flávio Martins Dos Santos, Patrícia Alves Barros, Nedja Poliane Torres Medeiros, Gilberto Sabino-Santos Júnior, Magliones Carneiro de Lima, Luiz Tadeu Moraes Figueiredo, Alessandra Abel Borges
INTRODUCTION: Hantavirus cardiopulmonary syndrome (HCPS) is rare in Northeastern Brazil. METHODS: Prospective surveillance was conducted over a two-year period in Alagoas State, Northeastern Brazil. The prevalence of anti-hantavirus N-antigen IgM and IgG in human serum samples was determined by enzyme-linked immunosorbent assay testing. RESULTS: High avidity IgG was found in nine of 476 serum samples tested (from 102 patients with clinical manifestations compatible with HCPS, 124 patients with leptospirosis, and 250 healthy rural workers)...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340454/human-leptospirosis-in-the-federal-district-brazil-2011-2015-eco-epidemiological-characterization
#4
Ivanildo de Oliveira Correia Santos, Marina Frota de Albuquerque Landi, Laurício Monteiro Cruz, Maria Isabel Rao Bofill, Divino Eterno Dos Santos, Eduardo Maurício Mendes de Lima, Márcio Botelho de Castro
INTRODUCTION: Leptospirosis is an infectious disease that affects more than 5,000 people per year in Brazil. The Federal District (FD) lacks epidemiological studies of human leptospirosis and presents concerning rates of this disease, especially considering its lethality. METHODS: Seventy-nine autochthonous human cases of leptospirosis between 2011 and 2015 were analyzed, with the probable infection location serving as a basis for the collection and analysis of the environmental and epidemiological variables...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29332210/pathogen-specific-leptospiral-proteins-in-urine-of-patients-with-febrile-illness-aids-in-differential-diagnosis-of-leptospirosis-from-dengue
#5
R Chaurasia, K C Thresiamma, C K Eapen, B J Zachariah, R Paul, M Sritharan
Leptospirosis and dengue are two commonly seen infectious diseases of the tropics. Differential diagnosis of leptospirosis from dengue fever is often difficult due to overlapping clinical symptoms and lack of economically viable and easy-to-perform laboratory tests. The gold standard for diagnosis is the microscopic agglutination test (MAT). In this study, the diagnostic potential of screening for pathogen-specific leptospiral antigens in urine samples is presented as a non-invasive method of disease diagnosis...
January 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29326780/cardiac-magnetic-resonance-of-myocardial-involvement-in-leptospirosis
#6
Onkar B Auti, Kanav Kansal, K V Shrikanth, Vimal Raj
Leptospirosis is a zoonotic infection caused by the Leptospira interrogans. Although it is endemic in tropical countries, global incidence has increased in several temperate and developed regions. Here, we present a cardiac magnetic resonance (CMR) and multidetector computer tomography (MDCT) chest features of active systemic leptospiral infection in a 19-year-old male. The MDCT appearances of lungs and CMR appearances of myocardium in icteric leptospirosis are described. Early diagnosis and prompt treatment is important to manage the cardiothoracic complications...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29318786/detection-of-pathogenic-leptospira-species-associated-with-phyllostomid-bats-mammalia-chiroptera-from-veracruz-mexico
#7
G G Ballados-González, S Sánchez-Montes, D Romero-Salas, P Colunga Salas, R Gutiérrez-Molina, L León-Paniagua, I Becker, M L Méndez-Ojeda, C Barrientos-Salcedo, R Serna-Lagunes, A Cruz-Romero
The genus Leptospira encompass 22 species of spirochaetes, with ten pathogenic species that have been recorded in more than 160 mammals worldwide. In the last two decades, the numbers of records of these agents associated with bats have increased exponentially, particularly in America. Although order Chiroptera represents the second most diverse order of mammals in Mexico, and leptospirosis represents a human and veterinary problem in the country, few studies have been conducted to identify potential wildlife reservoirs...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29313575/a-study-of-clinical-profile-of-patients-presenting-with-complications-of-acute-febrile-illnesses-during-monsoon
#8
Kaustubh Dilip Salagre, Ravindra Nath Sahay, Amar R Pazare, Abhishek Dubey, Kunal K Marathe
Background: The objective of this study was to describe clinico-laboratory profile and outcome of complicated acute febrile illnesses among inpatients in a tertiary care hospital during monsoon. Methods: This was an observational, prospective study conducted in a tertiary care hospital in Mumbai, India. Between July 2016 to October 2016, adult patients admitted to the hospital with complicated acute febrile illness were included. Demographic, clinical and laboratory data were collected and analyzed for each patient...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29305960/antibiotic-susceptibilities-of-livestock-isolates-of-leptospira
#9
Geoffroy Liegeon, Tristan Delory, Mathieu Picardeau
Leptospirosis is the most common zoonotic disease and is endemic worldwide. The antibiotic susceptibilities of Leptospira isolated from both humans and animals are poorly documented. This issue is particularly important for isolates from food-producing animals which are regularly exposed to antibiotic treatments. In this study, we assess the susceptibility of 35 Leptospira strains isolated from food-producing animals of diverse geographical origins between 1936 and 2016 to the antimicrobial agents most commonly used in animals...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29304782/prevalence-of-bovine-viral-diarrhoea-virus-bvdv-bovine-herpes-virus-1-bhv-1-leptospirosis-and-neosporosis-and-associated-risk-factors-in-161-irish-beef-herds
#10
Damien Barrett, Mervyn Parr, John Fagan, Alan Johnson, Jamie Tratalos, Francis Lively, Michael Diskin, David Kenny
BACKGROUND: There are limited data available, in Ireland or elsewhere, to determine the extent of exposure to various endemic diseases among beef cows and factors associated with exposure to causative pathogens. The objectives of this study were to determine the herd and within herd prevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BHV-1), Leptospirosis and Neosporosis in a large scale study of commercial beef herds on the island of Ireland, and to examine herd level factors associated with exposure to these pathogens in these herds...
January 6, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29286406/high-throughput-parallel-sequencing-to-measure-fitness-of-leptospira-interrogans-transposon-insertion-mutants-during-golden-syrian-hamster-infection
#11
Kristel Lourdault, James Matsunaga, Karen V Evangelista, David A Haake
In this manuscript, we describe a transposon sequencing (Tn-Seq) technique to identify and quantify Leptospira interrogans mutants altered in fitness during infection of Golden Syrian hamsters. Tn-Seq combines random transposon mutagenesis with the power of high-throughput sequencing technology. Animals are challenged with a pool of transposon mutants (input pool), followed by harvesting of blood and tissues a few days later to identify and quantify the number of mutants in each organ (output pools). The output pools are compared to the input pool to evaluate the in vivo fitness of each mutant...
December 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29284246/changes-in-leptospirosis-etiology-in-animals-and-humans
#12
Natalia Vasylieva, Mykhaylo Andreychyn, Yulia Kravchuk, Оlena Chervinska, Iaryna Iosyk
INTRODUCTION: Leptospirosis is endemic in Ternopil region. In Ukraine, the disease is registered in almost all regions, including the Ternopil region. The aim of the research is to study the regularities of epidemic and epizootic processes of leptospirosis, and the circulation of its pathogens among different sources (small mammals, animals) and humans. MATERIAL AND METHODS: Etiologic spectrum of leptospirosis registered in Ternopil region in 1972-2016 among small mammals, farm animals and sick people was studied...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29279785/leptospira-seroprevalence-in-domestic-dogs-and-cats-on-the-caribbean-island-of-saint-kitts
#13
Nicola Pratt, Anne Conan, Sreekumari Rajeev
Leptospirosis is an important bacterial zoonotic disease that affects humans and many animal species. Knowledge of prevalence of Leptospira in a given geographic region supports the implementation of effective control/prevention programmes and thus reduces the transmission risks. This study provides Leptospira seroprevalence and serovar distribution in dogs and cats on the Caribbean island of Saint Kitts. Convenient serum samples from domestic dogs (n = 101) and cats (n = 50) were tested by the microscopic agglutination test (MAT) using 21 Leptospira serovars belonging to 17 serogroups...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/29277333/isolation-of-leptospira-kmetyi-from-residential-areas-of-patients-with-leptospirosis-in-kelantan-malaysia
#14
Mohammad Ridhuan Mohd Ali, Amira Wahida Mohamad Safiee, Nik Yuszrin Yusof, Mohd Hashairi Fauzi, Chan Yean Yean, Nabilah Ismail
BACKGROUND: Environmental sampling provides important information that enhances the understanding of the leptospiral human-environment-animal relationship. Several studies have described the distribution of Leptospira in the environment. However, more targeted sites, that is, areas surrounding leptospirosis patients' houses, remain under-explored. Therefore, this study aims to detect the presence of Leptospira spp. in the residential areas of patients with leptospirosis. METHODS: Soil and water samples near leptospirosis patients' residences were collected, processed and cultured into EMJH media...
December 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29261446/mortality-trends-in-northern-sea-otters-enhydra-lutris-kenyoni-collected-from-the-coasts-of-washington-and-oregon-2002-15
#15
C LeAnn White, Emily W Lankau, Deanna Lynch, Susan Knowles, Krysten L Schuler, Jitender P Dubey, Valerie I Shearn-Bochsler, Marcos Isidoro-Ayza, Nancy J Thomas
During 2002-15 we examined the causes of mortality in a population of northern sea otters ( Enhydra lutris kenyoni). Beachcast sea otters were collected primarily from the coast of Washington. Although there are no permanent sea otter residents in Oregon, several beachcast otters were collected from the Oregon coast. Infectious diseases were the primary cause of death (56%) for otters we examined. Sarcocystosis was the leading infectious cause of death (54%) and was observed throughout the study period. Some infectious diseases, such as morbilliviral encephalitis and leptospirosis, were documented for a limited number of years and then not detected again despite continued testing for these pathogens in necropsied animals...
December 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29250519/evaluating-the-surveillance-system-for-spotted-fever-in-brazil-using-machine-learning-techniques
#16
Diego Montenegro Lopez, Flávio Luis de Mello, Cristina Maria Giordano Dias, Paula Almeida, Milton Araújo, Monica Avelar Magalhães, Gilberto Salles Gazeta, Reginaldo Peçanha Brasil
This work analyses the performance of the Brazilian spotted fever (SF) surveillance system in diagnosing and confirming suspected cases in the state of Rio de Janeiro (RJ), from 2007 to 2016 (July) using machine-learning techniques. Of the 890 cases reported to the Disease Notification Information System (SINAN), 11.7% were confirmed as SF, 2.9% as dengue, 1.6% as leptospirosis, and 0.7% as tick bite allergy, with the remainder being diagnosed as other categories (10.5%) or unspecified (72.7%). This study confirms the existence of obstacles in the diagnostic classification of suspected cases of SF by clinical signs and symptoms...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29239713/leptospira-venezuelensis-sp-nov-a-new-member-of-the-intermediate-group-isolated-from-rodents-cattle-and-humans
#17
Rafael Puche, Ignacio Ferrés, Lizeth Caraballo, Yaritza Rangel, Mathieu Picardeau, Howard Takiff, Gregorio Iraola
Three strains, CLM-U50T, CLM-R50 and IVIC-Bov1, belonging to the genus Leptospira, were isolated in Venezuela from a patient with leptospirosis, a domestic rat (Rattus norvegicus) and a cow (Bos taurus), respectively. The initial characterisation of these strains based on the rrs gene (16S rRNA) suggested their designation as a novel species within the 'intermediates' group of the genus Leptospira. Further phylogenomic characterisation based on single copy core genes was consistent with their separation into a novel species...
December 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29236931/comparative-genomics-of-pathogenic-leptospira-interrogans-serovar-canicola-isolated-from-swine-and-human-in-brazil
#18
Luisa Z Moreno, Fabiana Miraglia, Frederico S Kremer, Marcus R Eslabao, Odir A Dellagostin, Walter Lilenbaum, Julio C Freitas, Silvio A Vasconcellos, Marcos B Heinemann, Andrea M Moreno
Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is considered highly adapted to dogs, serovar Canicola infection has already been described in other animals and even a few human cases. Here, we present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains isolated from slaughtered sows (L0-3 and L0-4) and their comparison with human strain Fiocruz LV133. It was observed that the porcine serovar Canicola strains present the genetic machinery to cause human infection and, therefore, represent a higher risk to public health...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29236923/whole-genome-sequencing-of-leptospira-interrogans-from-southern-brazil-genetic-features-of-a-highly-virulent-strain
#19
Sérgio Jorge, Frederico Schmitt Kremer, Natasha Rodrigues de Oliveira, Gabrielle de Oliveira Sanches Valerio Navarro, Amanda Munari Guimarães, Christian Domingues Sanchez, Rafael Danelon Dos Santos Woloski, Karine Forster Ridieri, Vinícius Farias Campos, Luciano da Silva Pinto, Odir Antônio Dellagostin
BACKGROUND Leptospirosis is the most widespread zoonotic disease. It is caused by infection with pathogenic Leptospira species, of which over 300 serovars have been described. The accurate identification of the causative Leptospira spp. is required to ascertain the pathogenic status of the local isolates. OBJECTIVES This study aimed to obtain the complete genome sequence of a virulent Leptospira interrogans strain isolated from southern Brazil and to describe its genetic features. METHODS The whole genome was sequenced by next-generation sequencing (Ion Torrent)...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29235397/leptospira-interrogans-outer-membrane-protein-lipl21-is-a-potent-inhibitor-of-neutrophil-myeloperoxidase
#20
Monica L Vieira, Aline F Teixeira, Giselle Pidde-Queiroz, Ana T C Ching, Denise V Tambourgi, Ana Lucia T O Nascimento, Heiko Herwald
Leptospirosis is a widespread zoonotic and neglected infectious disease of human and veterinary concern that is caused by pathogenic Leptospira species. After entrance in the host, pathogenic leptospires evade the host natural defense mechanisms in order to propagate and disseminate to multiple organs. Myeloperoxidase is an enzyme stored in neutrophils azurophilic granules, and is released upon neutrophil activation to produce mainly hypochlorous acid, a strong oxidant and potent antimicrobial agent. In the present investigation, we studied the modulation of myeloperoxidase activity by L...
December 13, 2017: Virulence
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