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Michel Sadelain
CARs are synthetic receptors that reprogram immune cells for therapeutic purposes. They comprise three canonical domains for antigen recognition, T cell activation, and costimulation. The CAR cDNA is genetically integrated in the T cell genome. Autologous CAR T cells are generated from the patient's peripheral blood T cells and expand in the recipient to eliminate the targeted tumor. To view this Bench to Bedside, open or download the PDF.
December 14, 2017: Cell
Swetha S M Bhat, Binson Babu, Mikhail Feygenson, Joerg C Neuefeind, Manikoth M Shaijumon
Herein we report a new Na-insertion electrode material, Na2Ti9O19, as a potential candidate for Na-ion hybrid capacitors. We study the structural properties of nanostructured Na2Ti9O19, synthesized by hydrothermal technique, upon electrochemical cycling vs. Na. Average and local structure of Na2Ti9O19 are elucidated from neutron Rietveld refinement and pair distribution function (PDF), respectively, to investigate the initial discharge and charge events. Rietveld refinement reveals electrochemical cycling of Na2Ti9O19 is driven by single phase solid solution reaction during (de)sodiation without any major structural deterioration, keeping the average structure intact...
December 15, 2017: ACS Applied Materials & Interfaces
Andrés Bustamante, Juan Sotelo-Campos, Daniel G Guerra, Martin Floor, Christian A M Wilson, Carlos Bustamante, Mauricio Báez
The original version of this article contained an error in the spelling of the author Christian A.M. Wilson, which was incorrectly given as Christian M.A. Wilson. This has now been corrected in both the PDF and HTML versions of the article.
December 14, 2017: Nature Communications
Kai Liao, Xi-Long Fan, Xuheng Ding, Marek Biesiada, Zong-Hong Zhu
The original PDF version of this Article inadvertently highlighted the author surnames and omitted the publication date. These have now been corrected in the PDF version of the Article. The HTML version was correct from the time of publication.
December 12, 2017: Nature Communications
Matthew E Sykes, Jon W Stewart, Gleb M Akselrod, Xiang-Tian Kong, Zhiming Wang, David J Gosztola, Alex B F Martinson, Daniel Rosenmann, Maiken H Mikkelsen, Alexander O Govorov, Gary P Wiederrecht
The originally published version of this Article contained an error in Equation 1. The two ℏ terms were missing from this equation. This has now been corrected in the PDF and HTML versions of the Article.
December 12, 2017: Nature Communications
Ramunas Stepanauskas, Elizabeth A Fergusson, Joseph Brown, Nicole J Poulton, Ben Tupper, Jessica M Labonté, Eric D Becraft, Julia M Brown, Maria G Pachiadaki, Tadas Povilaitis, Brian P Thompson, Corianna J Mascena, Wendy K Bellows, Arvydas Lubys
The original version of this Article contained errors in the units of concentration of three reagents listed in the Methods. These errors have all been corrected in both the PDF and HTML versions of the Article.
December 12, 2017: Nature Communications
Alan Farhan, Charlotte F Petersen, Scott Dhuey, Luca Anghinolfi, Qi Hang Qin, Michael Saccone, Sven Velten, Clemens Wuth, Sebastian Gliga, Paula Mellado, Mikko J Alava, Andreas Scholl, Sebastiaan van Dijken
The original version of this article contained an error in the legend to Figure 4. The yellow scale bar should have been defined as '~600 nm', not '~600 µm'. This has now been corrected in both the PDF and HTML versions of the article.
December 12, 2017: Nature Communications
Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J Wang, Rohit Loomba, Jasmohan S Bajaj, Mitchell L Schubert, Masoumeh Sikaroodi, Patrick M Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B Ho, Jessica DePew, Xin Du, Henrik T Sørensen, Hendrik Vilstrup, Karen E Nelson, David A Brenner, Derrick E Fouts, Bernd Schnabl
In the original PDF version of this Article, which was published on 16 October 2017, the publication date was incorrectly given as 10 October 2017. This has now been corrected in the PDF; the HTML version of the paper was correct from the time of publication.
December 12, 2017: Nature Communications
Shruti Muralidharan, Viswanathan Mohan, Ranjit Mohan Anjana, Sidhant Jena, Nikhil Tandon, Steven Allender, Harish Ranjani
BACKGROUND: The prevalence of type 2 diabetes is increasing in epidemic proportions in low- and middle-income countries. There is an urgent need for novel methods to tackle the increasing incidence of diabetes. The ubiquity of mobile phone use and access to Internet makes mobile health (mHealth) technology a viable tool to prevent and manage diabetes. OBJECTIVE: The objective of this randomized controlled trial is to implement and evaluate the feasibility, cost-effectiveness, and sustainability of a reality television-based lifestyle intervention program...
December 12, 2017: JMIR Research Protocols
(no author information available yet)
Summaries of the articles in this issue are given in the PDF file.
December 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Jocelyn J Herstein, Paul D Biddinger, Shawn G Gibbs, Aurora B Le, Katelyn C Jelden, Angela L Hewlett, John J Lowe
CONTEXT: US state public health departments played key roles in planning for and responding to confirmed and suspected cases of Ebola virus disease (EVD) during the 2014-2016 outbreak, including designating select hospitals as high-level isolation units (HLIUs) for EVD treatment in conjunction with the Centers for Disease Control and Prevention. OBJECTIVE: To identify existing guidelines and perspectives of state health departments pertaining to the management and transport of patients with EVD and other highly hazardous communicable diseases (HHCDs)...
December 7, 2017: Journal of Public Health Management and Practice: JPHMP
Andrew Tessler, Kareen El Beyrouty, Natasha Crapnell
This study investigates the nature and behaviour of illegal gamblers in Hong Kong. A face-to-face street survey of 512 gamblers was conducted in Hong Kong between September and December 2015 with supplementary convenience sampling allowing for analysis of a total sample of 103 illegal gamblers. 56% of illegal gamblers recorded results consistent with this study's definition of 'excessive gambling' [i.e. moderate risk and problem gamblers under the Problem Gambling Severity Index (PGSI)]. 81% of surveyed illegal gamblers were male, 77% were aged between 30 and 49 and 67% were in blue collar occupations...
2017: Asian Journal of Gambling Issues and Public Health
Janko Nikolich-Žugich
In the version of this article initially published, the year of birth provided (1960) was incorrect. The correct year is 1961. The error has been corrected in the HTML and PDF versions of the article.
December 8, 2017: Nature Immunology
Wu-Mei Yuan, Wan-Ju Zhang, Fen-Lian Ma, Jin-Song Li, Qian Zhang, Li-Shu Zheng
Background: Many studies have investigated the characteristics and biological activities of type III interferon (IFN), finding that it has similar features to type I IFN but also unique actions because it is recognized by a different receptor. Results: A full-length recombinant human IFN-λ1 (rhIFN-λ1) cDNA was cloned into the pDF expression vector and stably expressed in Flp-In-CHO cells. After four purification steps (ammonium sulfate precipitation, SP Sepharose chromatography, Blue Sepharose 6 fast flow affinity chromatography and molecular sieve chromatography), the rhIFN-λ1 had a purity of about 90% and was found to have the predicted biological activities...
2017: Cellular & Molecular Biology Letters
Noriaki Tabata, Daisuke Sueta, Eiichiro Yamamoto, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Kenshi Yamanaga, Masanobu Ishii, Kenji Sakamoto, Hisanori Kanazawa, Koichiro Fujisue, Shinsuke Hanatani, Hirofumi Soejima, Seiji Hokimoto, Yasuhiro Izumiya, Sunao Kojima, Hiroshige Yamabe, Koichi Kaikita, Kenichi Tsujita
Background: As progress is made in successfully treating cancer, there is increasing need to focus on the risk and complexity of treating cardiovascular events in cancer survivors - thus, the field of onco-cardiology/cardio-oncology has emerged. We examined the differential incidence of cardiovascular events after percutaneous coronary intervention (PCI) in patients with or without cancer. Methods and Results: Participants were divided into a non-cancer group and a cancer group, which consisted of patients who were receiving or had ever received cancer treatment...
December 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
Patrick A Rafter, Daniel M Sigman, Katherine R M Mackey
The original version of this Article contained errors in Fig. 2b and Table 2. In Fig. 2b, the white circle labels were incorrectly positioned as they referred to scenarios that were used in an earlier version of the Article. In Table 2, the following three sentences were removed from the legend 'The last two calculations are discussed in the "Methods". The first assumes that all dissolved plus the ≈0.3 nmol kg-1 of particulate iron (measured in the eastern equatorial Pacific30) is bioavailable. The last calculation assumes EUC dissolved iron concentrations from 140° W'...
December 5, 2017: Nature Communications
Shawn M Lyons, Dorota Gudanis, Steven M Coyne, Zofia Gdaniec, Pavel Ivanov
The original version of this Article contained an error in the spelling of the author Steven M. Coyne, which was incorrectly given as Stephen M. Coyne. This has now been corrected in both the PDF and HTML versions of the Article.
December 5, 2017: Nature Communications
Adam T Devlin, David A Jay, Stefan A Talke, Edward D Zaron, Jiayi Pan, Hui Lin
Are perturbations to ocean tides correlated with changing sea-level and climate, and how will this affect high water levels? Here, we survey 152 tide gauges in the Pacific Ocean and South China Sea and statistically evaluate how the sum of the four largest tidal constituents, a proxy for the highest astronomical tide (HAT), changes over seasonal and interannual time scales. We find that the variability in HAT is significantly correlated with sea-level variability; approximately 35% of stations exhibit a greater than ±50 mm tidal change per meter sea-level fluctuation...
December 5, 2017: Scientific Reports
C J Newcomb, N P Qafoku, J W Grate, V L Bailey, J J De Yoreo
In the original version of this Article, the Acknowledgements section omitted the Department of Energy-funded Environmental and Molecular Sciences Laboratory in which the XRD measurements were performed. This error has now been corrected in both the PDF and HTML versions of the Article.
December 5, 2017: Nature Communications
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2017: Journal of Neurologic Physical Therapy: JNPT
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