Axel Heep, Peter Bartmann, Birgit Stoffel-Wagner, Arie Bos, Eelco Hoving, Oebele Brouwer, Albert Teelken, Carlo Schaller, Deborah Sival
INTRODUCTION: The pathophysiology involved in human neonatal high-pressure hydrocephalus (HC) includes both cerebrospinal fluid (CSF) malabsorption and obstruction. OBJECTIVE: The aim was to estimate the relative contribution between CSF malabsorption and obstruction in three different etiological groups of neonatal high-pressure HC by assessment of specific CSF biomarkers indicative of growth factor- and fibrosis-related CSF malabsorption (transforming growth factor beta-1 (TGF beta-1), aminoterminal propeptide of type 1 collagen (PC1NP)]...
October 2006: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery