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https://www.readbyqxmd.com/read/28422585/validation-of-the-ipaq-against-different-accelerometer-cut-points-in-older-cancer-survivors-and-adults-at-risk-of-cancer
#1
Liane S Lewis, James Hernon, Allan Clark, John M Saxton
INTRODUCTION: The present study investigated the convergent validity of an interview-administered IPAQ long version (IPAQ-L) in an older population by comparison with objective accelerometry movement data. METHODS: Data from 52 participants (mean age 67.9 years, 62% male) were included in the analysis. Treadmill derived (TM-ACC: 1952-5724 cpm) and free-living physical activity (PA) derived (FL-ACC: 760-5724 cpm) accelerometer cut-points were used as criterion. RESULTS: IPAQ-L measures (total PA, leisure-time, walking-time, sedentary time) were significantly correlated with accelerometry (P≤0...
April 19, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28421318/mental-health-care-use-in-children-of-parents-with-mental-health-problems-results-of-the-bella-study
#2
A Plass-Christl, F Klasen, C Otto, C Barkmann, H Hölling, Toni Klein, S Wiegand-Grefe, M Schulte-Markwort, U Ravens-Sieberer
Whether parental mental health problems facilitate or hinder the use of mental health care of the parents´ children is still unclear. The present cross sectional study examined mental health care use and potential predictors in a population based sample. Children of parents with mental health problems (CPM) were nearly 5 times more likely to use mental health care compared to children of parents without mental health problems. A multiple regression analysis revealed that the most important predictors of mental health care use for CPM were active family life (OR = 2...
April 18, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28420901/discrepancy-between-non-invasive-prenatal-genetic-testing-nipt-and-amniotic-chromosomal-test-due-to-placental-mosaicism-a-case-report-and-literature-review
#3
Kei Hayata, Yuji Hiramatsu, Hisashi Masuyama, Eriko Eto, Takashi Mitsui, Shoko Tamada
We experienced a case of advanced maternal age in which a fetus was found to be positive for trisomy 18 at re-examination following indeterminate non-invasive prenatal genetic testing (NIPT), the amniotic fluid chromosomal test revealed a normal karyotype, and confined placental mosaicism (CPM) was observed in an SNP microarray analysis of the placenta. The child was born with no defects or complications. In the present case, the result of the original NIPT at week 15 of pregnancy was indeterminate and the subsequent re-examination result was positive; since the definitive normal diagnosis was not reported until the latter half of week 21, the pregnant patient was subjected to psychological stress for a long period of time...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28420082/can-early-rehabilitation-prevent-posttraumatic-osteoarthritis-in-the-patellofemoral-joint-after-anterior-cruciate-ligament-rupture-understanding-the-pathological-features
#4
Nai-Jen Chang, Ming-You Shie, Kuan-Wei Lee, Pei-Hsi Chou, Chih-Chan Lin, Chih-Jou Chu
Knee instability resulting from anterior cruciate ligament (ACL) rupture is a high-risk factor for posttraumatic osteoarthritis (PTOA) in the patellofemoral joint (PFJ). However, whether non-weight-bearing and weight-bearing treatments have chondroprotective effects remains unclear. Twenty-four adult New Zealand White male rabbits were employed in this study. All animals received ACL transection in the right knee and sham surgery in the left knee. The rabbits were randomly assigned to the following groups: (I) In the sedentary (SED) group, the rabbits (n = 6) were simply kept in their cage; (II) In the continuous passive motion (CPM) group, the rabbits (n = 6) performed CPM exercise for 7 days, starting from the first postoperative day; (III) In the active treadmill exercise (TRE) group, the rabbits (n = 6) performed TRE for 2 weeks; (IV) In the CPM + TRE group, the rabbits (n = 6) executed CPM exercise, followed by TRE...
April 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28419527/the-rectosigmoid-brake-review-of-an-emerging-neuromodulation-target-for-colorectal-functional-disorders
#5
Anthony Y Lin, Phil G Dinning, Tony Milne, Ian P Bissett, Gregory O'Grady
The regulation of gastrointestinal motility encompasses several overlapping mechanisms including highly regulated and coordinated neurohormonal circuits. Various feedback mechanisms or 'brakes' have been proposed. While duodenal, jejunal, and ileal brakes are well described, a putative distal colonic brake is less well defined. Despite the high prevalence of colonic motility disorders, there is little knowledge of colonic motility owing to difficulties with organ access and technical difficulties in recording detailed motor patterns along its entire length...
April 16, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28418103/neurogenic-and-myogenic-patterns-of-electrical-activity-in-isolated-intact-mouse-colon
#6
T J Hibberd, M Costa, L Travis, S J H Brookes, D A Wattchow, J Feng, H Hu, N J Spencer
BACKGROUND: Relatively little is known about the electrical rhythmicity of the whole colon, where long neural pathways are preserved. METHODS: Smooth muscle electrical activity was recorded extracellularly from the serosa of isolated flat-sheet preparations consisting of the whole mouse colon (n=31). KEY RESULTS: Two distinct electrical patterns were observed. The first, long intense spike bursts, occurred every 349±256 seconds (0.2±0.2 cpm), firing action potentials for 31±11 seconds at 2...
April 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28409497/identification-of-myoelectric-signals-of-pregnant-rat-uterus-new-method-to-detect-myometrial-contraction
#7
Kálmán F Szűcs, György Grosz, Miklós Süle, Anikó Nagy, Zita Tiszai, Reza Samavati, Róbert Gáspár
AIM: To develop an electromyography method for pregnant rat uterus in vivo and to separate myometrial signals from the gastrointestinal tract signals. METHODS: Pregnant Sprague-Dawley rats (n=8) were anaesthetized and their stomach, small intestine, and large intestine were removed from the abdomen. A pair of thread electrodes was inserted into the uterus, while a pair of disk electrodes was placed subcutaneously above the myometrium. Additionally, a strain gauge sensor was fixed on the surface of the myometrium and cecum for the parallel detection of mechanical contractions in rats (n=18) with intact gastrointestinal tract...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28403269/mid-face-volumization-with-hyaluronic-acid-injection-technique-and-safety-aspects-from-a-controlled-randomized-double-blind-clinical-study
#8
Welf Prager, Karla Agsten, Maria Kravtsov, Prof Martina Kerscher
<p>BACKGROUND: Injection of hyaluronic acid (HA) volumizing fillers in the malar area is intended for rejuvenation of the mid-face. The choice of products, depth, and technique of injection depends on the desired level of volume enhancement and practitioners' preferences.</p> <p>OBJECTIVE: To describe a volumizing injection technique in the scope of a controlled, randomized, double-blind, single-center, split-face clinical study. MATERIALS & METHODS: A total of 45 subjects with bilateral symmetrical moderate to severe volume loss in the malar area received a single 2 mL injection of CPM®-26 (Cohesive Polydensified Matrix®) on one side and VYC®-20 (VYCROSS®) on the contralateral side of the face...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28392953/acute-psychosis-as-main-manifestation-of-central-pontine-myelinolysis
#9
Mangala Gopal, Melvin Parasram, Harsh Patel, Chike Ilorah, Hrachya Nersesyan
Central pontine myelinolysis (CPM) is an acute demyelinating neurological disorder affecting primarily the central pons and is frequently associated with rapid correction of hyponatremia. Common clinical manifestations of CPM include spastic quadriparesis, dysarthria, pseudobulbar palsy, and encephalopathy of various degrees; however, coma, "locked-in" syndrome, or death can occur in most severe cases. Rarely, CPM presents with neuropsychiatric manifestations, such as personality changes, acute psychosis, paranoia, hallucinations, or catatonia, typically associated with additional injury to the brain, described as extrapontine myelinolysis (EPM)...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28390804/open-vs-endoscopic-cricopharyngeal-myotomy-is-there-a-difference
#10
Colin Huntley, Maurits Boon, Joseph Spiegel
INTRODUCTION: The upper esophageal sphincter (UES) is composed largely of the cricopharyngeus muscle (CP) and acts as the gatekeeper to the esophagus. There are multiple methods of treating UES dysfunction, but myotomy has been shown to be the most definitive means. We aim to evaluate the difference between open and endoscopic CP myotomy (CPM). METHODS: A retrospective review of all patients undergoing endoscopic and open CPM was undertaken. We recorded demographic, clinical, operative, hospital, and postoperative data for both groups from January 2010-March 2015...
March 31, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28389183/influence-of-the-cross-linking-agent-on-mechanical-properties-of-pmma-powder-with-compromised-particle-morphology
#11
Tassanaporn Saen-Isara, Surachai Dechkunakorn, Niwat Anuwongnukroh, Toemsak Srikhirin, Siriporn Tanodekaew, Wassana Wichai
OBJECTIVE: To investigate the effect of a cross-linking agent on the mechanical properties of self-cured orthodontic acrylic resin using PMMA powder (CPM-PMMA) with a compromised microstructure. MATERIALS AND METHODS: The mechanical properties of three sample groups were investigated in this study: CPM-PMMA, orthocryl and orthoplast. CPM-PMMA powder was prepared by suspension polymerization. It was mixed with a commercially available liquid (orthocryl) to yield a test specimen and to compare its flexural properties and Vicker hardness with the two commercial products...
April 4, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28387936/the-plasticity-of-descending-controls-in-pain-translational-probing
#12
Kirsty Bannister, A H Dickenson
Descending controls, comprising pathways that originate in midbrain and brainstem regions and project onto the spinal cord, have long been recognized as key links in the multiple neural networks that interact to produce the overall pain experience. There is clear evidence from preclinical and clinical studies that both peripheral and central sensitisation play important roles in determining the level of pain perceived. Much emphasis has been put on spinal cord mechanisms in central excitability, but it now becoming clear that spinal hyperexcitability can be regulated by descending pathways from the brain that originate from predominantly noradrenergic and serotonergic systems...
April 7, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28384687/patient-reactions-to-surgeon-recommendations-about-contralateral-prophylactic-mastectomy-for-treatment-of-breast-cancer
#13
Steven J Katz, Nancy K Janz, Paul Abrahamse, Lauren P Wallner, Sarah T Hawley, Lawrence C An, Kevin C Ward, Ann S Hamilton, Monica Morrow, Reshma Jagsi
Importance: Guidelines assert that contralateral prophylactic mastectomy (CPM) should be discouraged in patients without an elevated risk for a second primary breast cancer. However, little is known about the impact of surgeons discouraging CPM on patient care satisfaction or decisions to seek treatment from another clinician. Objective: To examine the association between patient report of first-surgeon recommendation against CPM and the extent of discussion about it with 3 outcomes: patient satisfaction with surgery decisions, receipt of a second opinion, and receipt of surgery by a second surgeon...
April 5, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28383546/mosaic-trisomy-16-what-are-the-obstetric-and-long-term-childhood-outcomes
#14
Teresa N Sparks, Kao Thao, Mary E Norton
PURPOSE: To evaluate obstetric and neonatal outcomes as well as long-term neurodevelopmental outcomes and quality of life among prenatally detected cases of mosaic trisomy (MT16) and confined placental mosaicism (CPM) for trisomy 16. METHODS: We recruited participants for this cross-sectional study through an international registry of families with children diagnosed with MT16 or CPM. Parents were interviewed about expectations based on prenatal counseling as well as about actual perinatal outcomes, congenital anomalies, medical conditions, and school progress...
April 6, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28381219/cardiorespiratory-fitness-levels-and-associations-with-physical-activity-and-body-composition-in-young-south-african-adults-from-soweto
#15
A Prioreschi, S Brage, K Westgate, S A Norris, L K Micklesfield
BACKGROUND: This observational study aims to describe fitness, and objectively measured physical activity levels and patterns in 409 young black South African adults (aged 19-20 years) from Soweto, as well as to examine associations between physical activity, fitness and BMI. METHODS: A sub-maximal ramped step test was used to obtain an estimate of maximal oxygen uptake (VO2max). Physical activity was measured using ActiGraph (GT1M) for 7 days in 256 participants...
April 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28378711/input-respiratory-impedance-in-mice-comparison-between-the-flow-based-and-the-wavetube-method-to-perform-the-forced-oscillation-technique
#16
Vitor Mori, Maria Olveira, Mauro Vargas, Aline da Cunha, Rodrigo de Souza, Paulo Pitrez, Henrique Moriya
In this study, we estimated the Constant Phase Model (CPM) parameters from the respiratory impedance of male BALB/c mice by performing the forced oscillation technique (FOT) in a control group (n=8) and in a murine model of asthma (OVA) (n=10). Then, we compared the results obtained by two different methods, using a flow-based commercial equipment (flexiVent-flexiWare 7.x; SCIREQ, Montreal, Canada) (FXV) and a Wavetube method equipment (Sly et al 2003) (WVT). We believe that the results from different methods may not be comparable...
April 5, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28377848/childhood-predictors-of-adolescent-behaviour-the-prospective-association-of-familial-factors-with-meeting-physical-activity-guidelines
#17
Helen Elizabeth Brown, Kirsten Corder, Andrew J Atkin, Esther M F van Sluijs
Little is known about the longitudinal association of familial socio-demographic factors, behaviours, attitudes, or home environment with meeting physical activity guidelines. Our objective was to a) describe 4-year change in the prevalence of meeting guidelines, and characteristics of participants across categories of physical activity maintenance, and b) identify familial factors in childhood that are longitudinally associated with meeting guidelines in adolescence. Data on 17 parent- and child-reported family variables and objectively measured physical activity (ActiGraph GT1M) were available from 406 children (10...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28368614/theoretical-cross-sections-of-the-inelastic-fine-structure-transition-m-2-p1-2-ng-%C3%A2-m-2-p3-2-ng-for-m-k-rb-cs-and-ng-he-ne-ar
#18
Charlton D Lewis, David Eugene Weeks
Scattering matrix elements of the inelastic fine structure transition M((2)P1/2) + Ng ↔ M((2)P3/2) + Ng are computed using the Channel Packet Method (CPM) for alkali-metal atoms M = K, Rb, Cs, as they collide with noble-gas atoms Ng = He, Ne, Ar. The calculations are performed within the block Born-Oppenheimer approximation where excited state VA(2)Π1/2(R), VA(2)Πj(R), and VB(2)Σ(+)1/2(R) adiabatic potential energy surfaces are used together with a Hund's case (c) basis to construct a 6x6 diabatic representation of the electronic Hamiltonian...
April 3, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28355431/state-variation-in-the-receipt-of-a-contralateral-prophylactic-mastectomy-among-women-who-received-a-diagnosis-of-invasive-unilateral-early-stage-breast-cancer-in-the-united-states-2004-2012
#19
Rebecca Nash, Michael Goodman, Chun Chieh Lin, Rachel A Freedman, Laura S Dominici, Kevin Ward, Ahmedin Jemal
Importance: The use of contralateral prophylactic mastectomies (CPMs) among patients with invasive unilateral breast cancer has increased substantially during the past decade in the United States despite the lack of evidence for survival benefit. However, whether this trend varies by state or whether it is correlated with changes in proportions of reconstructive surgery among these patients is unclear. Objective: To determine state variation in the temporal trend and in the proportion of CPMs among women with early-stage unilateral breast cancer treated with surgery...
March 29, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28353057/levetiracetam-clinical-pharmacokinetic-monitoring-in-pediatric-patients-with-epilepsy
#20
REVIEW
Jason Tan, Vanessa Paquette, Marc Levine, Mary H H Ensom
Levetiracetam is a broad-spectrum antiepileptic drug (AED) with a unique mechanism of action. Older AEDs can cause serious short- and long-term adverse drug reactions and complications, rendering them undesirable to use in pediatric patients. Characteristics that make levetiracetam a near-ideal AED include its broad spectrum of activity, good tolerability profile, and minimal drug-drug interactions. Clinical pharmacokinetic monitoring (CPM) is often recommended in pediatric patients for certain AEDs due to large interindividual pharmacokinetic differences and unpredictable drug disposition...
March 28, 2017: Clinical Pharmacokinetics
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