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Wenjie Wu, Peng Cheng, Jingtong Lyu, Zehua Zhang, Jianzhong Xu
OBJECTIVE: We developed a Tag Array chip for detecting first- and second-line anti tuberculosis drug resistance in pulmonary tuberculosis and compared the analytical performance of the gene chip to that of phenotypic drug susceptibility testing (DST). METHODS: From November 2011 to April 2016.234 consecutive culture-confirmed, clinically and imaging diagnosed patients with pulmonary tuberculosis from Southwest Hospital, Chongqing were enrolled into the study. Specimens collected during sputum or bronchoalveolar lavage fluid from the pulmonary tuberculosis patients were subjected to M...
May 2018: Tuberculosis
Laura Hedges, Susan Brown, A Kenneth MacLeod, Audrey Vardy, Edward Doyle, Gina Song, Marjory Moreau, Miyoung Yoon, Thomas G Osimitz, Brian G Lake
1. The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. 2. DLM, CPM and TPM were metabolised by human CYP2B6 and CYP2C19, with the highest apparent intrinsic clearance (CLint ) values for pyrethroid metabolism being observed with CYP2C19. Other CYP enzymes contributing to the metabolism of one or more of the three pyrethroids were CYP1A2, CYP2C8, CYP2C9*1, CYP2D6*1, CYP3A4 and CYP3A5...
May 21, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Thorvaldur Skuli Palsson, Shellie A Boudreau, Hans Jørgen Krebs, Thomas Graven-Nielsen
Facilitated pain mechanisms have been demonstrated in musculoskeletal pain but it is unclear whether a recent painful injury leaves the pain system sensitized. Pain characteristics were assessed in individuals who recently recovered from ankle pain (recovered pain group; n=25) and sex-matched controls (n=25) in response to tonic-pressure pain and saline-induced pain applied at the shin muscle. Pain intensity and pain referral patterns were recorded bilaterally after the painful muscle stimulus. Pressure pain thresholds (PPTs) were measured at the lower legs and shoulder...
May 16, 2018: Journal of Pain: Official Journal of the American Pain Society
L Daines, S McLean, A Buelo, S Lewis, A Sheikh, H Pinnock
Substantial over-diagnosis and under-diagnosis of asthma in adults and children has recently been reported. As asthma is mostly diagnosed in non-specialist settings, a clinical prediction model (CPM) to aid the diagnosis of asthma in primary care may help improve diagnostic accuracy. We aim to systematically identify, describe, compare, and synthesise existing CPMs designed to support the diagnosis of asthma in children and adults presenting with symptoms suggestive of the disease, in primary care settings or equivalent populations...
May 18, 2018: NPJ Primary Care Respiratory Medicine
Estephan J Moana-Filho, Alberto Herrero Babiloni, Nicole R Theis-Mahon
Abnormal endogenous pain modulation (EPM) was suggested as a potential mechanism for chronic pain, i.e., increased pain facilitation and/or impaired pain inhibition underlying symptoms manifestation. EPM function can be tested using psychophysical methods such as temporal summation of pain (TSP) and conditioned pain modulation (CPM), which assess pain facilitation and inhibition, respectively. Several studies have investigated EPM function in patients with non-paroxysmal orofacial pain (OFP) and reported mixed results...
April 26, 2018: Pain
Daisuke Saito, Mari Hayashida, Taro Sato, Shintaro Minowa, Osamu Ikezaki, Tatsuya Mitsui, Miki Miura, Akihito Sakuraba, Tadakazu Hisamatsu
Background/Aims: Mesalazine is an effective drug for treating ulcerative colitis (UC), but causes allergic symptoms in a few cases. Therefore, the objective of this study was to evaluate the usefulness of the drug-induced lymphocyte stimulation test (DLST) for the diagnosis of mesalazine allergy. Methods: Patients with UC treated with mesalazine with or without a history of associated adverse events (AEs) were enrolled at Kyorin University Hospital from July 2016 to April 2017...
April 2018: Intestinal Research
Paul Adler, Andrew J Scally, Brendan T Barrett
BACKGROUND: To determine the test-retest reproducibility of accommodative facility (AF) measures in an unselected sample of UK primary school children. METHODS: Using ±2.00 DS flippers and a viewing distance of 40 cm, AF was measured in 136 children (range 4-12 years, average 8.1 ± 2.1) by five testers on three occasions (average interval between successive tests: eight days, range 1-21 days). On each occasion, AF was measured monocularly and binocularly, for two minutes...
May 8, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Wajid Farhad, Mumtaz Akhtar Cheema, Hafiz Mohkum Hammad, Muhammad Farrukh Saleem, Shah Fahad, Farhat Abbas, Ikramullah Khosa, Hafiz Faiq Bakhat
Poultry manure (PM), a rich source for crop nutrients, is produced in ample quantities worldwide. It provides necessary nutrient to soil and has a potential to improve plant water holding availability under semiarid environment. The effect of composted poultry manure (CPM) and irrigation regimes on morpho-physiology of selective maize (Zea mays L.) hybrids (H1 = drought tolerant, H2 = drought sensitive) was investigated in this study. Two field experiments were conducted during 2010 and 2011 under randomized complete block design with split split-plot arrangements and three replications of each treatment...
May 8, 2018: Environmental Science and Pollution Research International
Nisreen Elsayegh, Rachel D Webster, Angelica M Gutierrez Barrera, Heather Lin, Henry M Kuerer, Jennifer K Litton, Isabelle Bedrosian, Banu K Arun
Although multigene panel testing is increasingly common in patients with cancer, the relationship between its use among breast cancer patients with non-BRCA mutations or variants of uncertain significance (VUS) and disease management decisions has not been well described. This study evaluated the rate and predictive factors of CPM patients who underwent multigene panel testing. Three hundred and fourteen patients with breast cancer who underwent multigene panel testing between 2014 and 2017 were included in the analysis...
May 7, 2018: Cancer Medicine
Shaobo Mo, Weixing Dai, Wenqiang Xiang, Qingguo Li, Renjie Wang, Guoxiang Cai
BACKGROUND: The objective of this study was to summarize the clinicopathological and molecular features of synchronous colorectal peritoneal metastases (CPM). We then combined clinical and pathological variables associated with synchronous CPM into a nomogram and confirmed its utilities using decision curve analysis. MATERIALS AND METHODS: Synchronous metastatic colorectal cancer (mCRC) patients who received primary tumor resection and underwent KRAS, NRAS, and BRAF gene mutation detection at our center from January 2014 to September 2015 were included in this retrospective study...
May 3, 2018: International Journal of Surgery
Rohit Anand, Piyush C Kothary, Monte A Del Monte
Valproic acid (VPA) has been reported to inhibit cancer cell growth and has therapeutic use in retinal diseases. However, the mechanism of this action remains unclear. In order to explore this mechanism, primary human retinal pigment epithelial (hRPE) cell cultures were established. Cell viability was assessed by the trypan blue exclusion method (T), and the cell proliferation was measured by 3 H-thymidine incorporation (3H-thy). P38 synthesis was quantitated by using 14C-methionine-labeled P38 (14C-P38) by using P38-specific antibody...
2018: Advances in Experimental Medicine and Biology
Digna M González-Otero, Sofía Ruiz de Gauna, Jesus Ruiz, Raquel Rivero, J J Gutierrez, Purificación Saiz, James K Russell
BACKGROUND: Out-of-hospital cardiac arrest is common in public locations, including public transportation sites. Feedback devices are increasingly being used to improve chest-compression quality. However, their performance during public transportation has not been studied yet. OBJECTIVE: To test two CPR feedback devices representative of the current technologies (accelerometer and electromag- netic-field) in a long-distance train. METHODS: Volunteers applied compressions on a manikin during the train route using both feedback devices...
April 20, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Gil Samuelly-Leichtag, Einat Kodesh, Yoav Meckel, Irit Weissman-Fogel
Maximal anaerobic exercise, is a short high intensity effort, involves activation of the hypothalamus-pituitary-adrenal axis, and may suggest hypoalgesic effects. In addition, this exercise-induced muscle pain may contribute to hypoalgesia via the pain inhibits pain phenomenon, which is related to the diffuse noxious inhibitory control (DNIC) mechanism. We aimed to investigate whether: 1) a single bout of 30 s maximal anaerobic exercise has an analgesic effect on experimental pain sensitivity; 2) DNIC is the underlying mechanism of anaerobic exercise-induced hypoalgesia (EIH)...
April 26, 2018: International Journal of Sports Medicine
Xiang Zhao, Matthew S Shimazu, Xitong Chen, Xianhui Bu, Pingyun Feng
In porous materials, metal sites with coordinate solvents offer opportunities for many applications, especially those promoted by host-guest chemistry, but such sites are especially hard to create for Li-based materials, because unlike transition metals, lithium does not usually possess a high-enough coordination number for both framework construction and guest binding. This challenge is addressed by mimicking the functional group ratio and metal-to-ligand charge ratio in MOF-74. A family of rod-packing lithium-organic frameworks (CPM-47, CPM-48, and CPM-49) were obtained...
April 25, 2018: Angewandte Chemie
K Kang, Q Geng, H T Xu, X Z Zheng, J T Dong, T Li, Z G Zhao, S J Gao
Objective: To evaluate the effect of promoting knee joint rehabilitation after total knee arthroplasty (TKA) with a rehabilitation training instrument NEO-GAIT. Methods: Sixty patients who received TKA from January 2017 to July 2017 in the Third Hospital of Hebei Medical University were randomly assigned to receive rehabilitation training with continuous passive motion (CPM) or NEO-GAIT with random number (30 cases in CPM group, included 8 males and 22 females; 30 cases in NEO-GAIT group, included 6 males and 24 females)...
April 17, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jian Gao, Eileen Moran, Peter L Almenoff
BACKGROUND: Accurate risk adjustment is the key to a reliable comparison of cost and quality performance among providers and hospitals. However, the existing case-mix algorithms based on age, sex, and diagnoses can only explain up to 50 percent of the cost variation. More accurate risk adjustment is desired for provider performance assessment and improvement. OBJECTIVE: To develop a case-mix algorithm that hospitals and payers can use to measure and compare cost and quality performance of their providers...
April 17, 2018: Medical Care
Jessica I Billig, Anthony Duncan, Lin Zhong, Oluseyi Aliu, Erika D Sears, Kevin C Chung, Adeyiza O Momoh
BACKGROUND: Contralateral prophylactic mastectomy (CPM) may be unnecessary from an oncologic perspective; therefore, the debate persists about the value of CPM in women with early stage unilateral breast cancer. Given finite healthcare resources, this study aims to evaluate the cost of contralateral prophylactic mastectomy and breast reconstruction. STUDY DESIGN: Women with unilateral breast cancer undergoing either unilateral mastectomy or unilateral mastectomy with CPM and immediate breast reconstruction (IBR) were selected from the Truven MarketScan databases between 2009 and 2013...
January 20, 2018: Plastic and Reconstructive Surgery
Leanne Bisset, Michelle Carty, Ashley Smith
OBJECTIVE: Lateral epicondylalgia (LE, tennis elbow) is characterised by both local tissue pathology and features indicative of secondary hyperalgesia. The aim of this study was to evaluate endogenous pain modulation characteristics in people with chronic LE, and to investigate the relationship between endogenous pain modulation and clinical characteristics. METHODS: This case control observational study included 25 participants with LE of at least 6 weeks' duration and 15 age-matched (±5▒y) healthy control participants, who were each evaluated in a single session...
April 3, 2018: Clinical Journal of Pain
Ali Alsouhibani, Henrik Bjarke Vaegter, Marie Hoeger Bement
Objective: Physically active individuals show greater conditioned pain modulation (CPM) compared with less active individuals. Understanding the effects of acute exercise on CPM may allow for a more targeted use of exercise in the management of pain. This study investigated the effects of acute isometric exercise on CPM. In addition, the between-session and within-session reliability of CPM was investigated. Design: Experimental, randomized crossover study. Setting: Laboratory at Marquette University...
April 3, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Hannah C Beird, Chia-Chin Wu, Davis R Ingram, Wei-Lien Wang, Asrar Alimohamed, Curtis Gumbs, Latasha Little, Xingzhi Song, Barry W Feig, Christina L Roland, Jianhua Zhang, Robert S Benjamin, Patrick Hwu, Alexander J Lazar, P Andrew Futreal, Neeta Somaiah
Well-differentiated (WD) liposarcoma is a low-grade mesenchymal tumor with features of mature adipocytes and high propensity for local recurrence. Often, WD patients present with or later progress to a higher-grade nonlipogenic form known as dedifferentiated (DD) liposarcoma. These DD tumors behave more aggressively and can metastasize. Both WD and DD liposarcomas harbor neochromosomes formed from amplifications and rearrangements of Chr 12q that encode oncogenes ( MDM2 , CDK4 , and YEATS2) and adipocytic differentiation factors ( HMGA2 and CPM) However, genomic changes associated with progression from WD to DD have not been well-defined...
April 2018: Cold Spring Harbor Molecular Case Studies
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