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https://www.readbyqxmd.com/read/28912489/incoherent-digital-holograms-acquired-by-interferenceless-coded-aperture-correlation-holography-system-without-refractive-lenses
#1
Manoj Kumar, A Vijayakumar, Joseph Rosen
We present a lensless, interferenceless incoherent digital holography technique based on the principle of coded aperture correlation holography. The acquired digital hologram by this technique contains a three-dimensional image of some observed scene. Light diffracted by a point object (pinhole) is modulated using a random-like coded phase mask (CPM) and the intensity pattern is recorded and composed as a point spread hologram (PSH). A library of PSHs is created using the same CPM by moving the pinhole to all possible axial locations...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903158/surgeon-influence-on-variation-in-receipt-of-contralateral-prophylactic-mastectomy-for-women-with-breast-cancer
#2
Steven J Katz, Sarah T Hawley, Ann S Hamilton, Kevin C Ward, Monica Morrow, Reshma Jagsi, Timothy P Hofer
Importance: Rates of contralateral prophylactic mastectomy (CPM) have markedly increased but we know little about the influence of surgeons on variability of the procedure in the community. Objective: To quantify the influence of the attending surgeon on rates of CPM and clinician attitudes that explained it. Design, Setting, and Participants: In this population-based survey study, we identified 7810 women with stages 0 to II breast cancer treated in 2013 to 2015 through the Surveillance, Epidemiology, and End Results registries of Georgia and Los Angeles County...
September 13, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28891721/the-regions-on-the-light-chain-of-botulinum-neurotoxin-type-a-recognized-by-t-cells-from-toxin-treated-cervical-dystonia-patients-the-complete-human-t-cell-recognition-map-of-the-toxin-molecule
#3
Minako Oshima, Philip Deitiker, Joseph Jankovic, M Zouhair Atassi
We have recently mapped the in vitro proliferative responses of T cells from botulinum neurotoxin type A (BoNT/A)-treated cervical dystonia (CD) patients with overlapping peptides encompassing BoNT/A heavy chain (residues 449-1296). In the present study, we determined the recognition profiles, by peripheral blood lymphocytes (PBL) from the same set of patients, of BoNT/A light (L) chain (residues 1-453) by using 32 synthetic overlapping peptides that encompassed the entire L chain. Profiles of the T-cell responses (expressed in stimulation index, SI; Z score based on transformed SI) to the peptides varied among the patients...
September 11, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28872693/modeling-continuous-response-variables-using-ordinal-regression
#4
Qi Liu, Bryan E Shepherd, Chun Li, Frank E Harrell
We study the application of a widely used ordinal regression model, the cumulative probability model (CPM), for continuous outcomes. Such models are attractive for the analysis of continuous response variables because they are invariant to any monotonic transformation of the outcome and because they directly model the cumulative distribution function from which summaries such as expectations and quantiles can easily be derived. Such models can also readily handle mixed type distributions. We describe the motivation, estimation, inference, model assumptions, and diagnostics...
September 5, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28870555/botulinum-toxin-alleviates-dysphagia-of-patients-with-inclusion-body-myositis
#5
Aleksi Schrey, Laura Airas, Manu Jokela, Jaakko Pulkkinen
OBJECTIVES: Oropharyngeal dysphagia is a disabling and undertreated symptom that often occurs in patients with sporadic inclusion body myositis (s-IBM). In this study, we examined the effect of botulinum neurotoxin A (BoNT-A) injections to the cricopharyngeus muscle (CPM) of patients with s-IBM and dysphagia. PATIENTS, MATERIALS AND METHODS: A single-center retrospective study involving 40 biopsy-proven s-IBM-patients treated in the District of Southwest Finland from 2000 to 2013...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28855352/low-dose-cyclophosphamide-induces-anti-tumor-t-cell-responses-which-associate-with-survival-in-metastatic-colorectal-cancer
#6
Martin J Scurr, Tom Pembroke, Anja Bloom, David J Roberts, Amanda Thomson, Kathryn Smart, Hayley Bridgeman, Richard A Adams, Alison E Brewster, Robert Jones, Sarah Gwynne, Daniel Blount, Richard Harrop, Robert Hills, Awen Gallimore, Andrew Godkin
PURPOSE: Anti-cancer T-cell responses can control tumors, but immune-suppressive mechanisms in vivo prevent their function. The role of regulatory T-cells (Tregs) in metastatic colorectal cancer (mCRC) is unclear. We have previously shown depletion of Tregs enhances CRC-specific effector T-cell responses. Low dose cyclophosphamide (CPM) targets Tregs in animal models and some human studies, however the effect of CPM in mCRC is unknown. EXPERIMENTAL DESIGN: Fifty-five mCRC patients were enrolled onto a phase I/II trial and randomized to receive two week-long courses of low-dose (50mg twice-a-day) CPM or not...
August 29, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28854251/facilitatory-and-inhibitory-pain-mechanisms-are-altered-in-patients-with-carpal-tunnel-syndrome
#7
Benjamin Soon, Bill Vicenzino, Annina B Schmid, Michel W Coppieters
Preliminary evidence from studies using quantitative sensory testing suggests the presence of central mechanisms in patients with carpal tunnel syndrome (CTS) as apparent by widespread hyperalgesia. Hallmarks of central mechanisms after nerve injuries include nociceptive facilitation and reduced endogenous pain inhibition. Methods to study nociceptive facilitation in CTS so far have been limited to quantitative sensory testing and the integrity of endogenous inhibition remains unexamined. The aim of this study was therefore to investigate changes in facilitatory and inhibitory processing in patients with CTS by studying hypersensitivity following experimentally induced pain (facilitatory mechanisms) and the efficacy of conditioned pain modulation (CPM, inhibitory mechanisms)...
2017: PloS One
https://www.readbyqxmd.com/read/28852026/a-time-series-transcriptome-analysis-of-cassava-manihot-esculenta-crantz-varieties-challenged-with-ugandan-cassava-brown-streak-virus
#8
T Amuge, D K Berger, M S Katari, A A Myburg, S L Goldman, M E Ferguson
A time-course transcriptome analysis of two cassava varieties that are either resistant or susceptible to cassava brown streak disease (CBSD) was conducted using RNASeq, after graft inoculation with Ugandan cassava brown streak virus (UCBSV). From approximately 1.92 billion short reads, the largest number of differentially expressed genes (DEGs) was obtained in the resistant (Namikonga) variety at 2 days after grafting (dag) (3887 DEGs) and 5 dag (4911 DEGs). At the same time points, several defense response genes (encoding LRR-containing, NBARC-containing, pathogenesis-related, late embryogenesis abundant, selected transcription factors, chaperones, and heat shock proteins) were highly expressed in Namikonga...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851323/evoked-potentials-after-painful-cutaneous-electrical-stimulation-depict-pain-relief-during-a-conditioned-pain-modulation
#9
Oliver Höffken, Özüm S Özgül, Elena K Enax-Krumova, Martin Tegenthoff, Christoph Maier
BACKGROUND: Conditioned pain modulation (CPM) evaluates the pain modulating effect of a noxious conditioning stimulus (CS) on another noxious test stimulus (TS), mostly based solely on subjective pain ratings. We used painful cutaneous electrical stimulation (PCES) to induce TS in a novel CPM-model. Additionally, to evaluate a more objective parameter, we recorded the corresponding changes of cortical evoked potentials (PCES-EP). METHODS: We examined the CPM-effect in 17 healthy subjects in a randomized controlled cross-over design during immersion of the non-dominant hand into 10 °C or 24 °C cold water (CS)...
August 29, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28846134/mineral-trioxide-aggregate-and-other-bioactive-endodontic-cements-an-updated-overview-part-ii-other-clinical-applications-and-complications
#10
REVIEW
M Torabinejad, M Parirokh, P M H Dummer
Mineral trioxide aggregate (MTA) is a dental material used extensively for vital pulp therapy (VPT), scaffold cover during regenerative endodontic procedures, apical barrier in teeth with necrotic pulps and open apices, perforation repair, and root canal filling and root-end filling during surgical endodontics. A number of bioactive endodontic cements (BECs) have recently been introduced to the market. Most of these materials had calcium and silicate in their compositions; however, the bioactivity is the common property of these cements...
August 28, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28844107/impacts-of-a-care-process-model-and-inpatient-electrophysiology-service-on-cardiovascular-implantable-electronic-device-infections-a-preliminary-evaluation
#11
Eugene M Tan, Avish Nagpal, Daniel C DeSimone, Brenda Anderson, Jane Linderbaum, Thomas De Ziel, Zhuo Li, Muhammad R Sohail, Yong-Mei Cha, Erica Loomis, Raul Espinosa, Paul A Friedman, Kevin Greason, Henry Schiller, Abinash Virk, Walter R Wilson, James M Steckelberg, Larry M Baddour
PURPOSE: Cardiovascular implantable electronic device infection (CIEDI) rates are rising. To improve outcomes, our institution developed an online care process model (CPM) and a specialized inpatient heart rhythm service (HRS). METHODS: This retrospective review compared hospital length of stay (LOS), mortality, and times to subspecialty consultation and procedures before and after CPM and HRS availability. RESULTS: CPM use was associated with shortened time to surgical consultation (median 2 days post-CPM vs...
August 26, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28837598/accelerometer-assessed-sedentary-work-leisure-time-and-cardio-metabolic-biomarkers-during-one-year-effectiveness-of-a-cluster-randomized-controlled-trial-in-parents-with-a-sedentary-occupation-and-young-children
#12
Arto J Pesola, Arto Laukkanen, Risto Heikkinen, Sarianna Sipilä, Arja Sääkslahti, Taija Finni
BACKGROUND: It is unknown whether reducing sedentary time at work and during leisure time is possible and effective during one year. METHODS: Office workers with young children were recruited for this one-year cluster-randomized controlled trial through kindergartens and primary schools from 7 clusters in the city of Jyväskylä, Finland. After a lecture, face-to-face tailored counseling was used to set contractually binding goals regarding reducing and breaking up sitting periods and increasing light intensity physical activity during work and leisure time...
2017: PloS One
https://www.readbyqxmd.com/read/28836288/mineral-trioxide-aggregate-and-other-bioactive-endodontic-cements-an-updated-overview-part-i-vital-pulp-therapy
#13
REVIEW
M Parirokh, M Torabinejad, P M H Dummer
Mineral trioxide aggregate (MTA) is a bioactive endodontic cement (BEC) mainly comprised of calcium and silicate elements. The cement was introduced by Torabinejad in the 1990s and has been approved by the Food and Drug Administration (FDA) to be used in the U.S. in 1997. A number of new Bioactive Endodontic Cements (BECs) have also been introduced to the market, including BioAggregate, Biodentine, BioRoot RCS, calcium enriched mixture (CEM) cement, CAPSEAL, Endo-CPM, Endocem, EndoSequence, EndoBinder, EndoSeal MTA, iRoot, MicroMega MTA, MTA Bio, MTA Fillapex, MTA Plus, Neo MTA Plus, Ortho MTA, Quick-Set, Retro MTA, Tech Biosealer, and TheraCal...
August 24, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28833988/beyond-weakness-characterization-of-pain-sensory-profile-and-conditioned-pain-modulation-in-patients-with-motor-neuron-disease-a-controlled-study
#14
L C G Lopes, R Galhardoni, V Silva, F M H Jorge, L T Yeng, D Callegaro, G Chadi, M J Teixeira, D Ciampi de Andrade
BACKGROUND: Motor neuron diseases (MND) represent a group of disorders that evolve with inexorable muscle weakness and medical management is based on symptom control. However, deeper characterization of non-motor symptoms in these patients have been rarely reported. METHODS: This cross-sectional study aimed to describe non-motor symptoms in MND and their impact on quality of life and functional status, with a focus on pain and sensory changes. Eighty patients (31 females, 55...
August 22, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28833500/primary-stability-of-a-cementless-acetabular-cup-in-a-cohort-of-patient-specific-finite-element-models
#15
Dermot O' Rourke, Rami Al-Dirini, Mark Taylor
The primary stability achieved during total hip arthroplasty determines the long-term success of cementless acetabular cups. Pre-clinical finite element testing of cups typically use a model of a single patient and assume the results can be extrapolated to the general population. This study explored the variability in predicted primary stability of a Pinnacle ® cementless acetabular cup in 103 patient-specific finite element models of the hemipelvis and examined the association between patient-related factors and the observed variability...
August 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28829938/fluoride-ion-release-of-self-adhesive-resin-cements-and-their-potential-to-inhibit-in-situ-enamel-and-dentin-demineralization
#16
V A Pellizzari, A C Michels, S T Luiz, E M de Souza, Cpm Tabchoury, R N Rached
OBJECTIVE: This study evaluated in situ the potential of a glass ionomer and self-adhesive resin cements to inhibit enamel and dentin demineralization around indirect restorations exposed to cariogenic challenge. The cumulative fluoride release (CFR) of materials was measured in water and acid. METHODS: Seventy blocks cut from human molars received two indirect composite restorations (one in enamel and another in dentin) luted with Ketac Cem EasyMix (GIC, positive control), SeT (SeT), Maxcem Elite (Max), Smart Cem2 (Smart), and RelyX Unicem 2 (Unicem2)...
September 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28821392/schisandra-chinensis-extract-decreases-chloroacetaldehyde-production-in-rats-and-attenuates-cyclophosphamide-toxicity-in-liver-kidney-and-brain
#17
Jianxiu Zhai, Feng Zhang, Shouhong Gao, Li Chen, Ge Feng, Jun Yin, Wansheng Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandra chinensis (Turcz.) Baill (S. chinensis) has been used for thousands years in China, and is usually applied in treatment of urinary tract disorders and liver injury. S. chinensis extract (SCE) has board protective effects on liver, kidney and nervous system. Schisandra lignans are generally considered as the bioactive components of SCE. AIM OF THE STUDY: To investigate the pharmacokinetic herb-drug interactions (HDIs) between SCE and cyclophosphamide (CTX)...
August 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28811185/the-effect-of-receptor-status-on-mastectomy-and-contralateral-prophylactic-mastectomy-rates-in-early-stage-invasive-breast-carcinoma
#18
Sunil W Dutta, Daniel M Trifiletti, Surbhi Grover, Kara D Romano, Einsley-Marie Janowski, Shayna L Showalter
BACKGROUND: There is an established relationship between hormone receptor (HR; estrogen and/or progesterone receptors) status, HER2 status, and locoregional recurrence. The purpose of this study was to analyze how HR and HER2 receptor status have influenced the surgical management trends among patients with early stage breast cancer. PATIENTS AND METHODS: The National Cancer Database was queried for patients with cT1 to cT3, cN0, and cM0 breast carcinoma from 2004 to 2012...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28810062/the-association-between-patient-attitudes-and-values-and-the-strength-of-consideration-for-contralateral-prophylactic-mastectomy-in-a-population-based-sample-of-breast-cancer-patients
#19
Sarah T Hawley, Kent A Griffith, Ann S Hamilton, Kevin C Ward, Monica Morrow, Nancy K Janz, Steven J Katz, Reshma Jagsi
BACKGROUND: Little is known about how the individual decision styles and values of breast cancer patients at the time of treatment decision making are associated with the consideration of different treatment options and specifically with the consideration of contralateral prophylactic mastectomy (CPM). METHODS: Newly diagnosed patients with early-stage breast cancer who were treated in 2013-2014 were identified through the Surveillance, Epidemiology, and End Results registries of Los Angeles and Georgia and were surveyed approximately 7 months after surgery (n = 2578; response rate, 71%)...
August 15, 2017: Cancer
https://www.readbyqxmd.com/read/28807096/a-five-year-surveillance-of-carbapenemase-producing-klebsiella-pneumoniae-in-a-pediatric-hospital-in-china-reveals-increased-predominance-of-ndm-1
#20
Fang Dong, Jie Lu, Yan Wang, Jin Shi, Jing Hui Zhen, Ping Chu, Yang Zhen, Shu Jing Han, Yong Li Guo, Wen Qi Song
OBJECTIVE: To characterize carbapenem (CPM)-non-susceptible Klebsiella pneumoniae (K. pneumoniae) and carbape-nemase produced by these strains isolated from Beijing Children's Hospital based on a five-year surveillance. METHODS: The Minimal Inhibition Concentration values for 15 antibiotics were assessed using the Phonix100 compact system. PCR amplification and DNA sequencing were used to detect genes encoding carbapenemases. WHONET 5.6 was finally used for resistance analysis...
August 2017: Biomedical and Environmental Sciences: BES
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