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https://www.readbyqxmd.com/read/28713267/epoxyeicosatrienoic-acid-analog-decreases-renal-fibrosis-by-reducing-epithelial-to-mesenchymal-transition
#1
Melissa Skibba, Md Abdul Hye Khan, Lauren L Kolb, Michael M Yeboah, John R Falck, Radhika Amaradhi, John D Imig
Renal fibrosis, which is a critical pathophysiological event in chronic kidney diseases, is associated with renal epithelial-to-mesenchymal transition (EMT). Epoxyeicosatrienoic acids (EETs) are Cyp epoxygenase arachidonic acid metabolites that demonstrate biological actions that result in kidney protection. Herein, we investigated the ability of 14,15-EET and its synthetic analog, EET-A, to reduce kidney fibrosis induced by unilateral ureter obstruction (UUO). C57/BL6 male mice underwent sham or UUO surgical procedures and were treated with 14,15-EET or EET-A in osmotic pump (i...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28706998/the-extended-erlang-truncated-exponential-distribution-properties-and-application-to-rainfall-data
#2
I E Okorie, A C Akpanta, J Ohakwe, D C Chikezie
The Erlang-Truncated Exponential ETE distribution is modified and the new lifetime distribution is called the Extended Erlang-Truncated Exponential EETE distribution. Some statistical and reliability properties of the new distribution are given and the method of maximum likelihood estimate was proposed for estimating the model parameters. The usefulness and flexibility of the EETE distribution was illustrated with an uncensored data set and its fit was compared with that of the ETE and three other three-parameter distributions...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28704241/prognostic-value-of-electrocardiogram-exercise-testing-for-risk-stratification-in-asymptomatic-coronary-artery-disease
#3
Sara L Guerreiro, Jorge M Ferreira, João M Calqueiro, Miguel S Mendes
BACKGROUND: Several variables of electrocardiogram exercise testing (EET) predict cardiovascular events in the general population and in patients with coronary artery disease (CAD). However, most of the studies have not included patients with asymptomatic CAD. The aim of this study was to evaluate the prognostic value of EET in asymptomatic CAD patients. PATIENTS AND METHODS: We carried out a retrospective single-center analysis including all patients with asymptomatic CAD documented by angiography who underwent EET from January 2010 to December 2013...
July 12, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28698657/anaerobic-oxidation-of-methane-coupled-with-extracellular-electron-transfer-to-electrodes
#4
Yaohuan Gao, Jangho Lee, Josh D Neufeld, Joonhong Park, Bruce E Rittmann, Hyung-Sool Lee
Anaerobic oxidation of methane (AOM) is an important process for understanding the global flux of methane and its relation to the global carbon cycle. Although AOM is known to be coupled to reductions of sulfate, nitrite, and nitrate, evidence that AOM is coupled with extracellular electron transfer (EET) to conductive solids is relatively insufficient. Here, we demonstrate EET-dependent AOM in a biofilm anode dominated by Geobacter spp. and Methanobacterium spp. using carbon-fiber electrodes as the terminal electron sink...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695213/extracellular-polymeric-substances-are-transient-media-for-microbial-extracellular-electron-transfer
#5
Yong Xiao, Enhua Zhang, Jingdong Zhang, Youfen Dai, Zhaohui Yang, Hans E M Christensen, Jens Ulstrup, Feng Zhao
Microorganisms exploit extracellular electron transfer (EET) in growth and information exchange with external environments or with other cells. Every microbial cell is surrounded by extracellular polymeric substances (EPS). Understanding the roles of three-dimensional (3D) EPS in EET is essential in microbiology and microbial exploitation for mineral bio-respiration, pollutant conversion, and bioenergy production. We have addressed these challenges by comparing pure and EPS-depleted samples of three representative electrochemically active strains viz Gram-negative Shewanella oneidensis MR-1, Gram-positive Bacillus sp...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28694203/soluble-epoxide-hydrolase-inhibitor-auda-decreases-bleomycin-induced-pulmonary-toxicity-in-mice-by-inhibiting-the-p38-smad3-pathways
#6
Xin-Wei Dong, Yong-Liang Jia, Ling-Tian Ge, Bo Jiang, Jun-Xia Jiang, Shen Jian, Ya-Chao Jin, Guan Yan, Yun Sun, Qiang-Min Xie
Bleomycin (BLM) has potent tumor cell-killing properties that have given it an important place in cancer chemotherapy, but pulmonary toxicity is its major adverse effect. Soluble epoxide hydrolase (sEH) inhibitors have been reported to have protective effects in fibrosis models, but the effects of AUDA, an sEH inhibitor of BLM-induced pulmonary toxicity and fibrosis, remain to be researched. In this study, we assessed the effects of AUDA on the BLM-induced pulmonary fibrosis in a mouse model, and transforming growth factor (TGF)-β1-induced epithelial proliferation and epithelial-mesenchymal transition (EMT) in vitro by monitoring changes in pulmonary function, inflammatory response, fibrotic remodeling, and signaling pathways...
July 7, 2017: Toxicology
https://www.readbyqxmd.com/read/28687336/polymorphisms-of-cyp2c8-cyp2c9-and-cyp2c19-and-risk-of-coronary-heart-disease-in-russian-population
#7
Alexey Polonikov, Alexander Kharchenko, Marina Bykanova, Svetlana Sirotina, Irina Ponomarenko, Anna Bocharova, Kseniya Vagaytseva, Vadim Stepanov, Olga Bushueva, Mikhail Churnosov, Maria Solodilova
Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms (SNP) of genes coding cytochrome P450 2C subfamily, enzymes involved in biosynthesis of EETs, are associated with the risk of coronary heart disease (CHD). A total of 1255 unrelated Russian subjects comprising 561 patients with angiographically diagnosed CHD and 694 age- and sex-matched healthy subjects were included in the study...
July 4, 2017: Gene
https://www.readbyqxmd.com/read/28682418/effects-of-epoxyeicosatrienoic-acids-eets-on-retinal-macular-degeneration-in-rat-models
#8
F Mei, J-G Wang, Z-J Chen, Z-L Yuan
OBJECTIVE: Here we use a rat model to investigate the effects of epoxyeicosatrienoic acids (EETs) on retinal macular degeneration along with pathological and physiological mechanisms of the disease. MATERIALS AND METHODS: Six choroidal neovascularization (CNV) rats were created with a 532 nm laser and received intravitreal injections of EETs in both eyes. On day 1, 3, 7 and 14 after photocoagulation, the thickness and area of CNV were measured with HE staining and choroidal flat mounts...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28679057/real-time-quantum-dynamics-of-long-range-electronic-excitation-transfer-in-plasmonic-nanoantennas
#9
Niranjan V Ilawe, M Belén Oviedo, Bryan M Wong
Using large-scale, real-time, quantum dynamics calculations, we present a detailed analysis of electronic excitation transfer (EET) mechanisms in a multiparticle plasmonic nanoantenna system. Specifically, we utilize real-time, time-dependent, density functional tight binding (RT-TDDFTB) to provide a quantum-mechanical description (at an electronic/atomistic level of detail) for characterizing and analyzing these systems, without recourse to classical approximations. We also demonstrate highly long-range electronic couplings in these complex systems and find that the range of these couplings is more than twice the conventional cutoff limit considered by Förster resonance energy transfer (FRET)-based approaches...
July 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28676795/electricity-generation-by-shewanella-decolorationis-s12-without-cytochrome-c
#10
Yonggang Yang, Guannan Kong, Xingjuan Chen, Yingli Lian, Wenzong Liu, Meiying Xu
Bacterial extracellular electron transfer (EET) plays a key role in various natural and engineering processes. Outer membrane c-type cytochromes (OMCs) are considered to be essential in bacterial EET. However, most bacteria do not have OMCs but have redox proteins other than OMCs in their extracellular polymeric substances of biofilms. We hypothesized that these extracellular non-cytochrome c proteins (ENCP) could contribute to EET, especially with the facilitation of electron mediators. This study compared the electrode respiring capacity of wild type Shewanella decolorationis S12 and an OMC-deficient mutant...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28672788/n-3-polyunsaturated-fatty-acids-decrease-the-protein-expression-of-soluble-epoxide-hydrolase-via-oxidative-stress-induced-p38-kinase-in-rat-endothelial-cells
#11
Takashi Okada, Katsutaro Morino, Fumiyuki Nakagawa, Masashi Tawa, Keiko Kondo, Osamu Sekine, Takeshi Imamura, Tomio Okamura, Satoshi Ugi, Hiroshi Maegawa
N-3 polyunsaturated fatty acids (PUFAs) improve endothelial function. The arachidonic acid-derived metabolites (epoxyeicosatrienoic acids (EETs)) are part of the endothelial hyperpolarization factor and are vasodilators independent of nitric oxide. However, little is known regarding the regulation of EET concentration by docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in blood vessels. Sprague-Dawley rats were fed either a control or fish oil diet for 3 weeks. Compared with the control, the fish oil diet improved acetylcholine-induced vasodilation and reduced the protein expression of soluble epoxide hydrolase (sEH), a key EET metabolic enzyme, in aortic strips...
June 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28668023/resonant-energy-transfer-under-the-influence-of-the-evanescent-field-from-the-metal
#12
Amrit Poudel, Xin Chen, Mark A Ratner
We present a quantum framework based on a density matrix of a dimer system to investigate the quantum dynamics of excitation energy transfer (EET) in the presence of the evanescent field from the metal and the phonon bath. Due to the spatial correlation of the electric field in the vicinity of the metal, the spectral density of the evanescent field is similar to that of a shared phonon bath. However, the EET dynamics under the influence of the evanescent field is an open and a new problem. Here we use a thin metallic film to investigate the effect of the evanescent field on the excitation energy transfer in a dimer system based on a density matrix approach...
June 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28656267/epoxyeicosatrienoic-acid-ameliorates-cerebral-ischemia-reperfusion-injury-by-inhibiting-inflammatory-factors-and-pannexin-1
#13
Zhigang Liu, Yongfang Liu, Haixiao Zhou, Xiangyun Fu, Gang Hu
Epoxyeicosatrienoic acid (EET) has wide applications due to the unique biological effects of anti‑hyperlipidemia, inhibition of platelet aggregation, anti‑inflammation, anti‑cancer, anti‑lipid oxidation and the promotion of brain tissue development. The present study investigated whether EET ameliorates cerebral ischemia‑reperfusion injury (CIRI) by inhibiting inflammatory factors and pannexin. Specific pathogen‑free 7‑week‑old male Sprague‑Dawley rats were randomly divided into three groups: Sham, CIRI and EET...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28646029/editorial-focus-on-ms-h-00093-2017r1-are-the-epoxyeicosatrienoic-acids-eets-at-the-heart-of-the-b-eet-in-obesity-induced-cardiomyopathy
#14
Kevin C Dellsperger
This editorial focus discusses the accompanying paper in this issue as well as describing potential focus areas for future study in treating obesity induced cardiomyopathy.
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28643208/visual-outcomes-after-endoscopic-endonasal-pituitary-adenoma-resection-a-systematic-review-and-meta-analysis
#15
REVIEW
Ivo S Muskens, Amir H Zamanipoor Najafabadi, Vanessa Briceno, Nayan Lamba, Joeky T Senders, Wouter R van Furth, Marco J T Verstegen, Timothy R S Smith, Rania A Mekary, Christine A E Eenhorst, Marike L D Broekman
PURPOSE: Patients with pituitary adenomas often present with visual deficits. While the aim of endoscopic endonasal transsphenoidal surgery (EETS) is to improve these deficits, permanent worsening is a possible outcome. The aim of this meta-analysis was to evaluate the effect of EETS for pituitary adenomas on visual outcomes. METHODS: A meta-analysis was conducted according to the PRISMA guidelines. Pooled prevalence was calculated for complete recovery, improvement, and deterioration of visual field deficits, visual acuity and unspecified visual function in fixed- and random-effect models, including assessment of heterogeneity (I(2)) and publication bias (Begg's test)...
June 22, 2017: Pituitary
https://www.readbyqxmd.com/read/28628977/enhanced-performance-of-microbial-fuel-cell-with-in-situ-preparing-dual-graphene-modified-bioelectrode
#16
Junfeng Chen, Yongyou Hu, Xiaojun Tan, Lihua Zhang, Wantang Huang, Jian Sun
This study proposed a three-step method to prepare dual graphene modified bioelectrode (D-GM-BE) by in situ microbial-induced reduction of GO and polarity reversion in microbial fuel cell (MFC). Both graphene modified bioanode (GM-BA) and biocathode (GM-BC) were of 3D graphene/biofilm architectures; the viability and thickness of microbial biofilm decreased compared with control bioelectrode (C-BE). The coulombic efficiency (CE) of GM-BA was 2.1 times of the control bioanode (C-BA), which demonstrated higher rate of substrates oxidation; the relationship between peak current and scan rates data meant that GM-BC was of higher efficiency of catalyzing oxygen reduction than the control biocathode (C-BC)...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28616968/crispri-srna-transcriptional-translational-regulation-of-extracellular-electron-transfer-in-shewanella-oneidensis
#17
Yingxiu Cao, Xiaofei Li, Feng Li, Hao Song
Extracellular electron transfer (EET) in Shewanella oneidensis MR-1, which is one of the most well-studied exoelectrogens, underlies many microbial electrocatalysis processes, including microbial fuel cells, microbial electrolysis cells, and microbial electrosynthesis. However, regulating the efficiency of EET remains challenging due to the lack of efficient genome regulation tools that regulate gene expression levels in S. oneidensis. Here, we systematically established a transcriptional regulation technology, i...
June 15, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28616567/cyp2c19-variants-and-epoxyeicosatrienoic-acids-in-patients-with-microvascular-angina
#18
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto
BACKGROUND: Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the impact of CYP2C19 polymorphisms and EETs on the patients with microvascular angina (MVA) caused by coronary microvascular dysfunction. METHODS AND RESULTS: We examined CYP2C19 genotypes in patients with MVA (n = 81)...
June 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28608645/proton-transport-in-the-outer-membrane-flavocytochrome-complex-limits-the-rate-of-extracellular-electron-transport
#19
Akihiro Okamoto, Yoshihide Tokunou, Shafeer Kalathil, Kazuhito Hashimoto
The microbial transfer of electrons to extracellularly located solid compounds, termed extracellular electron transport (EET), is critical for microbial electrode catalysis. Although the components of the EET pathway in the outer membrane (OM) have been identified, the role of electron/cation coupling in EET kinetics is poorly understood. We studied the dynamics of proton transport associated with EET in an OM flavocytochrome complex in Shewanella oneidensis MR-1. Using a whole-cell electrochemical assay, a significant kinetic isotope effect (KIE) was observed following the addition of deuterated water (D2 O)...
June 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28588417/photosynthetic-pigment-protein-complexes-as-highly-connected-networks-implications-for-robust-energy-transport
#20
REVIEW
Lewis A Baker, Scott Habershon
Photosynthetic pigment-protein complexes (PPCs) are a vital component of the light-harvesting machinery of all plants and photosynthesizing bacteria, enabling efficient transport of the energy of absorbed light towards the reaction centre, where chemical energy storage is initiated. PPCs comprise a set of chromophore molecules, typically bacteriochlorophyll species, held in a well-defined arrangement by a protein scaffold; this relatively rigid distribution leads to a viewpoint in which the chromophore subsystem is treated as a network, where chromophores represent vertices and inter-chromophore electronic couplings represent edges...
May 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
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