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https://www.readbyqxmd.com/read/29787809/eet-enhances-renal-function-in-obese-mice-resulting-in-restoration-of-mfn1-2-ho-1-signaling-and-decrease-in-hypertension-through-inhibition-of-sodium-chloride-co-transporter
#1
Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P Singh, David Bamshad, John A McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T Stier, Nader G Abraham
BACKGROUND: We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on renal and adipose tissue function, in addition to its vasodilatory action; it increases insulin sensitivity and inhibits inflammation. In an examination of the signaling mechanisms by which EET reduces renal and peri-renal fat function, we hypothesized that EET ameliorates obesity-induced renal dysfunction by improving sodium excretion, reducing the sodium-chloride cotransporter NCC, lowering blood pressure, and enhancing mitochondrial and thermogenic gene levels in PGC-1α dependent mice...
May 19, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29786168/variation-in-electrode-redox-potential-selects-for-different-microorganisms-under-cathodic-current-flow-from-electrodes-in-marine-sediments
#2
Bonita R Lam, Annette R Rowe, Kenneth H Nealson
Extracellular electron transport (EET) is a microbial process that allows microorganisms to transport electrons to and from insoluble substrates outside of the cell. Although progress has been made in understanding how microbes transfer electrons to insoluble substrates, the process of receiving electrons has largely remained unexplored. We investigated redox potentials favorable for donating electrons to dissolved and insoluble components in Catalina Harbor marine sediment by combining electrochemical techniques with geochemistry and molecular methods...
May 22, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29778538/naringenin-exhibits-the-protective-effect-on-cardiac-hypertrophy-via-eets-ppars-activation-in-streptozocin-induced-diabetic-mice
#3
Jie Zhang, Hongmei Qiu, Jiajun Huang, Shumei Ding, Bo Huang, Qin Wu, Qingsong Jiang
Cardiac hypertrophy is one of the key structural changes in diabetic cardiomyopathy. Naringenin, a dihydroflavonoid extracted from citrus plants with multiple pharmacological activities, yet the underlying effects on diabetic cardiac hypertrophy remain unclear. This study aimed to evaluate the potential effects of naringenin on cardiac hypertrophy in diabetic mice. Long-term high-fat feeding combined with streptozotocin resulted in cardiac hypertrophy after a diabetic model has been established for 4 weeks in mice, which were improved by naringenin supplementation (25 or 75 mg/kg/day, i...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29777058/gpr40-is-a-low-affinity-epoxyeicosatrienoic-acid-receptor-in-vascular-cells
#4
Sang Kyu Park, Anja Herrnreiter, Sandra L Pfister, Kathryn M Gauthier, Benjamin A Falck, John R Falck, William B Campbell
Endothelium-derived epoxyeicosatrienoic acids (EETs) have numerous vascular activities mediated by G protein--coupled receptors. Long-chain free fatty acids and EETs activate GPR40, prompting us to investigate the role of GPR40 in some vascular EET activities. 14,15-EET, 11,12-EET, arachidonic acid, and the GPR40 agonist GW9508 increase intracellular calcium concentrations in human GPR40-overexpressing HEK293 cells (EC50 = 0.58 ± 0.08 μM, 0.91 ± 0.08 μM, 3.9 ± 0.06 μM and 19 ± 0.37 nM, respectively)...
May 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29743187/the-effects-of-farnesoid-x-receptor-activation-on-arachidonic-acid-metabolism-nf-kb-signaling-and-hepatic-inflammation
#5
Zhibo Gai, Michele Visentin, Ting Gui, Lin Zhao, Wolfgang E Thasler, Stephanie Hausler, Ivan Hartling, Alessio Cremonesi, Christian Hiller, Gerd A Kullak-Ublick
Inflammation has a recognized role in non-alcoholic fatty liver disease (NAFLD) progression. The present work studied the effect of high fat diet (HFD) on arachidonic acid metabolism in the liver and investigated the role of the farnesoid X receptor (FXR, NR1H4) in eicosanoid biosynthetic pathways and NF-kB signaling, major modulators of the inflammatory cascade. Mice were fed a HFD to induce NAFLD, then, treated with the FXR ligand obeticholic acid (OCA). Histology and gene expression analysis were performed on liver tissue...
May 9, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29740312/emotion-detection-deficits-and-decreased-empathy-in-patients-with-alzheimer-s-disease-and-parkinson-s-disease-affect-caregiver-mood-and-burden
#6
Maria Martinez, Namita Multani, Cassandra J Anor, Karen Misquitta, David F Tang-Wai, Ron Keren, Susan Fox, Anthony E Lang, Connie Marras, Maria C Tartaglia
Background : Changes in social cognition occur in patients with Alzheimer's disease (AD) and Parkinson's disease (PD) and can be caused by several factors, including emotion recognition deficits and neuropsychiatric symptoms (NPS). The aims of this study were to investigate: (1) group differences on emotion detection between patients diagnosed with AD or PD and their respective caregivers; (2) the association of emotion detection with empathetic ability and NPS in individuals with AD or PD; (3) caregivers' depression and perceived burden in relation to patients' ability to detect emotions, empathize with others, presence of NPS; and (4) caregiver's awareness of emotion detection deficits in patients with AD or Parkinson...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29722806/redox-gradient-driven-electron-transport-in-a-mixed-community-anodic-biofilm
#7
Matthew D Yates, Sarah Barr Engel, Brian J Eddie, Nikolai Lebedev, Anthony P Malanoski, Leonard M Tender
Here we describe the long distance (multi-cell-length) extracellular electron transport (LD-EET) that occurs in an anode-grown mixed community biofilm (MCB) enriched from river sediment that contains 3-45% Geobacter spp. High signal-to-noise temperature-dependent electrochemical gating measurements (EGM) using interdigitated microelectrode arrays reveal a peak-shaped electrical conductivity vs. potential dependency, indicating MCB acts as a redox conductor, similar to pure culture anode-grown Geobacter sulfurreducens biofilms (GSB)...
May 2, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29717935/expression-of-soluble-epoxide-hydrolase-in-renal-tubular-epithelial-cells-regulates-macrophage-infiltration-and-polarization-in-iga-nephropathy
#8
Qian Wang, Yan Liang, Yingjin Qiao, Xiangya Zhao, Yi Yang, Shengnan Yang, Bing Li, Qianru Zhao, Ling Dong, Songxia Quan, Rui Tian, Zhangsuo Liu
Tubulointerstitial inflammatory cell infiltration and activation contribute to kidney inflammation and fibrosis. Epoxyeicosatrienoic acids (EETs), which are rapidly metabolized to dihydroxyeicosatrienoic acids by the soluble epoxide hydrolase (sEH), have multiple biological functions, including vasodilation, anti-inflammatory action, and others. Inhibition of sEH has been demonstrated to attenuate inflammation in many renal disease models. However, the relationship between sEH expression and macrophage polarization in kidney remains unknown...
May 2, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29717802/the-effect-of-enriched-environment-across-ages-a-study-of-anhedonia-and-bdnf-gene-induction
#9
Brittany E Dong, Yueqiang Xue, Kazuko Sakata
Enriched environment treatment (EET) is a potential intervention for depression by inducing brain-derived neurotrophic factor (BDNF). However, its age dependency remains unclear. We recently found that EET during early-life development (ED) was effective in increasing exploratory activity and anti-despair behavior, particularly in promoter IV-driven BDNF deficient mice (KIV), with the largest BDNF protein induction in the hippocampus and frontal cortex. Here, we further determined age dependency of EET effects on anhedonia and promoter-specific BDNF transcription, by using the sucrose preference test and qRT-PCR...
May 2, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29708543/electrochemical-detection-of-deuterium-kinetic-isotope-effect-on-extracellular-electron-transport-in-shewanella-oneidensis-mr-1
#10
Yoshihide Tokunou, Kazuhito Hashimoto, Akihiro Okamoto
Direct electrochemical detection of c-type cytochrome complexes embedded in the bacterial outer membrane (outer membrane c-type cytochrome complexes; OM c-Cyts) has recently emerged as a novel whole-cell analytical method to characterize the bacterial electron transport from the respiratory chain to the cell exterior, referred to as the extracellular electron transport (EET). While the pathway and kinetics of the electron flow during the EET reaction have been investigated, a whole-cell electrochemical method to examine the impact of cation transport associated with EET has not yet been established...
April 16, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29707604/cyp-450-epoxygenase-derived-epoxyeicosatrienoic-acid-contribute-to-reversal-of-heart-failure-in-obesity-induced-diabetic-cardiomyopathy-via-pgc-1-%C3%AE-activation
#11
S P Singh, J A McClung, L Bellner, J Cao, M Waldman, J Schragenheim, M Arad, E Hochhauser, J R Falck, J A Weingarten, S J Peterson, N G Abraham
We have previously shown that an Epoxyeicosatrienoic Acid (EET) -agonist has pleiotropic effects and reverses cardiomyopathy by decreasing inflammatory molecules and increasing antioxidant signaling. We hypothesized that administration of an EET agonist would increase Peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), which controls mitochondrial function and induction of HO-1 and negatively regulates the expression of the proinflammatory adipokines CCN3/NOV in cardiac and pericardial tissues...
2018: Cardiovascular Pharmacology: Open Access
https://www.readbyqxmd.com/read/29703148/deletion-of-soluble-epoxide-hydrolase-attenuates-mice-hyperoxic-acute-lung-injury
#12
Li-Ping Liu, Bin Li, Tian-Kui Shuai, Lei Zhu, Yu-Min Li
BACKGROUND: Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear. METHODS: ALI was induced by exposure to 100% oxygen in an airtight cage for 72 h in wild-type (WT) and sEH gene deletion (EPHX2-/- ) mice. ALI was assessed by the lung dry/wet ratio, alveolar capillary protein leak, and the infiltration of inflammatory cells in the lung. RESULTS: Hyperoxia elevated sEH activity in WT mice...
April 27, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29695613/cytochrome-p450-2j2-potential-role-in-drug-metabolism-and-cardiotoxicity
#13
Meetal Satishkumar Solanki, Amy Pointon, Barry C Jones, Karl E Herbert
Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA) derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesised by cytochrome P450 2J2 (CYP2J2). The biological effects of EETs including its protective effects on inflammation and vasodilation are diverse due, in part, to their ability to act on a variety of cell types. In addition, CYP2J2 metabolises both exogenous and endogenous substrates and is involved in phase I metabolism of a variety of structurally diverse compounds including some antihistamines, anti-cancer agents and immunosuppressants...
April 25, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29689453/cross-talk-of-cannabinoid-and-endocannabinoid-metabolism-is-mediated-via-human-cardiac-cyp2j2
#14
William R Arnold, Austin T Weigle, Aditi Das
Phytocannabinoids have well-known cardiovascular implications. For instance, Δ9-tetrahydrocannabinol (Δ9-THC), the principal component of cannabis, induces tachycardia in humans. In order to understand the impact of phytocannabinoids on human cardiovascular health, there is a need to study the metabolism of phytocannabinoids by cardiac cytochromes p450 (CYPs). CYP2J2, the primary CYP of cardiomyocytes, is responsible for the metabolism of the endocannabinoid, anandamide (AEA), into cardioprotective epoxides (EET-EAs)...
April 7, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29684084/local-and-systemic-inflammatory-lipid-profiling-in-a-rat-model-of-osteoarthritis-with-metabolic-dysregulation
#15
H M de Visser, S C Mastbergen, S Ravipati, P M J Welsing, F C Pinto, F P J G Lafeber, V Chapman, D A Barrett, H Weinans
OBJECTIVE: Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally induced osteoarthritis to investigate the potential role of oxylipins as a marker in the disease process of early osteoarthritis. DESIGN: Forty rats were randomly allocated to a standard or high-fat diet group...
2018: PloS One
https://www.readbyqxmd.com/read/29665313/refinement-of-the-endogenous-epitope-tagging-eet-technology-allows-the-identification-of-a-novel-nras-binding-partner-in-melanoma
#16
Michal Alon, Rafi Emmanuel, Nouar Qutob, Anna Bakhman, Victoria Peshti, Alexandra Brodezki, David Bassan, Mickey Kosloff, Yardena Samuels
The NRAS oncoprotein is highly mutated in melanoma. However, to date, no comprehensive proteomic study has been reported for NRAS. Here we utilized the Endogenous Epitope Tagging (EET) approach for the identification of novel NRAS binding partners. Using EET, an epitope tag is added to the endogenously expressed protein, via modification of its genomic coding sequence. Existing EET systems are not robust, suffer from high background and are labor-intensive. To this end, we present a polyadenylation signal-trap construct for N'-tagging, that generates a polycistronic mRNA with the gene of interest...
April 17, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29664681/effect-of-bronchodilation-and-exercise-training-with-behavior-modification-on-exercise-tolerance-and-downstream-effects-on-symptoms-and-physical-activity-in-copd
#17
Thierry Troosters, François Maltais, Nancy Leidy, Kim L Lavoie, Maria Sedeno, Wim Janssens, Judith Garcia-Aymerich, Damijan Erzen, Dorothy De Sousa, Lawrence Korducki, Alan Hamilton, Jean Bourbeau
RATIONALE: Bronchodilation and exercise training (ExT) improve exercise tolerance in patients with chronic obstructive pulmonary disease (COPD); however, behavior modification is required to impact on daily physical activity (PA). OBJECTIVES: To assess whether tiotropium/olodaterol, ±ExT, would improve exercise endurance time (EET) and PA compared with placebo in patients participating in a self-management behavior-modification (SMBM) program. METHODS: A 12-week, randomized, partially double-blind, placebo-controlled, parallel-group trial in patients with COPD (PHYSACTO®; NCT02085161)...
April 17, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29664635/ultrafast-through-space-electronic-energy-transfer-in-molecular-dyads-built-around-dynamic-spacer-units
#18
Raymond Ziessel, Patrycja Stachelek, Anthony Harriman, Gordon J Hedley, Thomas J Roland, Arvydas Ruseckas, Ifor David William Samuel
A pair of complimentary molecular dyads have been synthesized around a 1,2-diaminocyclohexyl spacer that itself undergoes ring inversion. Despite these conformational exchange processes, the donor and acceptor occupy quite restricted spatial regions and they are not interchangeable. The donor and acceptor pair comprise disparate boron dipyrromethene dyes selected to display favorable electronic energy transfer (EET). Steady-state emission spectroscopy con-firms that through-space EET from donor to acceptor is almost quantitative, aided by the relatively short separations...
April 17, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29659278/mechanism-of-photoinduced-triplet-intermolecular-hydrogen-transfer-between-cycloxydim-and-chlorothalonil
#19
Qi Yuan, Dimitrios Toroz, Nathan Kidley, Ian R Gould
The possible reaction mechanisms for the experimentally observed hydrogen transfer between herbicide Cycloxydim (CD) and triplet fungicide Chlorothalonil (CT) were identified with density functional theory (DFT) and time dependent density function theory (TDDFT) computations. Excited energy transfer (EET) calculations indicate that reactants for intermolecular hydrogen transfer were formed via energy transfer from triplet CT to ground state CD. Three possible reaction pathways after EET were identified, and hydrogen transfer from the hydroxyl group on the cyclohexane ring of CD to CT exhibited the lowest energy barrier...
April 16, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29649873/ph-dependency-in-anode-biofilms-of-thermincola-ferriacetica-suggests-a-proton-dependent-electrochemical-response
#20
Bradley G Lusk, Isaias Peraza, Gaurav Albal, Andrew K Marcus, Sudeep C Popat, Cesar I Torres
Monitoring the electrochemical response of anode respiring bacteria (ARB) helps elucidate the fundamental processes of anode respiration and their rate limitations. Understanding these limitations provides insights on how ARB create the complex interfacing of biochemical metabolic processes with insoluble electron acceptors and electronics. In this study, anode biofilms of the thermophilic (60 °C) Gram-positive ARB Thermincola ferriacetica were studied to determine the presence of a proton-dependent electron transfer response...
April 17, 2018: Journal of the American Chemical Society
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