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https://www.readbyqxmd.com/read/28535299/analysis-of-bacterial-metagenomes-from-the-southwestern-gulf-of-mexico-for-pathogens-detection
#1
Wendy Escobedo-Hinojosa, Liliana Pardo-López
Little is known about the diversity of bacteria in the Southwestern Gulf of Mexico. The aim of the study illustrated in this perspective was to search for the presence of bacterial pathogens in this ecosystem, using metagenomic data recently generated by the Mexican research group known as the Gulf of Mexico Research Consortium. Several genera of bacteria annotated as pathogens were detected in water and sediment marine samples. As expected, native and ubiquitous pathogenic bacteria genera such as Burkolderia, Halomonas, Pseudomonas, Shewanella, and Vibrio were highly represented...
May 23, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28532993/canine-leptospirosis-in-switzerland-a-prospective-cross-sectional-study-examining-seroprevalence-risk-factors-and-urinary-shedding-of-pathogenic-leptospires
#2
Alessandro Delaude, Sabrina Rodriguez-Campos, Anou Dreyfus, Michel Jacques Counotte, Thierry Francey, Ariane Schweighauser, Sophie Lettry, Simone Schuller
Leptospirosis is an important worldwide zoonosis. While human leptospirosis remains rare in Switzerland, the incidence of canine leptospirosis is unusually high compared to other European countries. The aims of this cross-sectional study were to determine the exposure of asymtomatic dogs to pathogenic Leptospira in Switzerland, to characterise risk factors associated with seropositivity and to determine the prevalence of urinary shedding. Sampling was stratified to cover the whole of Switzerland. Sera were tested by microscopic agglutination test for antibodies against a panel of 12 serovars...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28529271/evidence-of-infection-with-leptospira-interrogans-and-spotted-fever-group-rickettsiae-among-rodents-in-an-urban-area-of-osaka-city-japan
#3
Kenta Shimizu, Rie Isozumi, Kazutoshi Takami, Isao Kimata, Kanae Shiokawa, Kumiko Yoshimatsu, Yoshimi Tsuda, Sanae Nishio, Jiro Arikawa
We examined 33 rodents captured in an urban area of Osaka City, Japan for IgG antibodies against Seoul virus, severe fever with thrombocytopenia syndrome virus, hepatitis E virus, Leptospira interrogans, Yersinia pestis, spotted fever, typhus and scrub typhus group rickettsiae. We found that 3 (9.1%) and 1 (3.0%) of the 33 rodents had antibodies against L. interrogans and spotted fever group rickettsiae, respectively. DNAs of leptospires were detected from 2 of the 3 seropositive rodents, but DNA of rickettsia was not detected...
May 22, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28527874/pressor-support-during-a-jarisch-herxheimer-reaction-after-initiation-of-treatment-for-weil-s-disease
#4
Randi Connor-Schuler, Anee Khan, Nikhil Goyal, Erin Zimny
We present a case of Weil's disease complicated by a Jarisch-Herxheimer reaction (JHR) after initiation of antibiotics while in the emergency department requiring invasive monitoring and vasopressor support. The case is followed by a brief review of the JHR which is rarely observed with treatment of leptospirosis. A healthy 28-year-old female who recently returned from the Caribbean presented to the emergency department with flu-like symptoms. The patient appeared jaundiced with conjunctival suffusion and was ultimately treated with the appropriate antibiotics for leptospirosis in the ED...
April 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28527249/-sociodemographic-and-clinical-characteristics-of-patients-infected-with-leptospira-spp-treated-at-four-hospitals-in-medell%C3%A3-n-colombia-2008-2013
#5
Lina María Echeverri-Toro, Sara Penagos, Laura Castañeda, Pablo Villa, Santiago Atehortúa, Faiver Ramírez, Carlos Restrepo, Sigifredo Ospina, Yuli Agudelo, Alicia Hidrón, Paola Agudelo, Eliana Valderrama, Carlos Andrés Agudelo
INTRODUCTION: Leptospirosis remains a significant health problem in tropical regions including Latin America, where its presentation is 100 times higher than that observed in other regions of the world. Mortality reaches 10% in severe cases. Its diagnosis is challenging because clinical manifestations during the initial phase are non-specific and because of limited availability of diagnostic tests. OBJECTIVE: To describe the demographic and clinical characteristics and the outcomes in hospitalized patients with leptospirosis...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28513759/-diagnosis-of-leptospirosis-in-dogs
#6
Michèle Bergmann, Julia-Rebecca Llewellyn, Katrin Hartmann
Rapid confirmation of the diagnosis leptospirosis is important in order to apply appropriate treatment; in addition, infected dogs are a zoonotic risk. Culture and isolation of living leptospires from blood, urine, or tissues is considered the reference standard of diagnosis. However, sensitivity are low, and leptospires require weeks to months to grow. Therefore, diagnosis of leptospirosis is most commonly based on antibody testing or the detection of Leptospira spp. DNA by PCR. Microscopic agglutination test (MAT) is currently still the recommended confirmatory test for canine leptospirosis, despite its numerous limitations (e...
May 17, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28505191/lp25-membrane-protein-from-pathogenic-leptospira-spp-is-associated-with-rhabdomyolysis-and-oliguric-acute-kidney-injury-in-a-guinea-pig-model-of-leptospirosis
#7
Patrícia A E Abreu, Antonio C Seguro, Daniele Canale, Ana Maria G da Silva, Larissa do R B Matos, Tatiane B Gotti, Denize Monaris, Denise A de Jesus, Sílvio A Vasconcellos, Thales de Brito, Antonio J B Magaldi
Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp...
May 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28500802/high-resolution-melting-curve-analysis-of-the-16s-ribosomal-gene-to-detect-and-identify-pathogenic-and-saprophytic-leptospira-species-in-colombian-isolates
#8
Ronald G Peláez Sánchez, Juan Álvaro López Quintero, Martha María Pereira, Piedad Agudelo-Flórez
AbstractIt is important to identify the circulating Leptospira agent to enhance the performance of serodiagnostic tests by incorporating specific antigens of native species, develop vaccines that take into account the species/serovars circulating in different regions, and optimize prevention and control strategies. The objectives of this study were to develop a polymerase chain reaction (PCR)-high-resolution melting (HRM) assay for differentiating between species of the genus Leptospira and to verify its usefulness in identifying unknown samples to species level...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28496441/discovery-of-novel-leptospirosis-vaccine-candidates-using-reverse-and-structural-vaccinology
#9
André Alex Grassmann, Frederico Schmitt Kremer, Júlia Cougo Dos Santos, Jéssica Dias Souza, Luciano da Silva Pinto, Alan John Alexander McBride
Leptospira spp. are diderm (two membranes) bacteria that infect mammals causing leptospirosis, a public health problem with global implications. Thousands of people die every year due to leptospirosis, especially in developing countries with tropical climates. Prophylaxis is difficult due to multiple factors, including the large number of asymptomatic hosts that transmit the bacteria, poor sanitation, increasing numbers of slum dwellers, and the lack of an effective vaccine. Several leptospiral recombinant antigens were evaluated as a replacement for the inactivated (bacterin) vaccine; however, success has been limited...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28491815/lethal-pulmonary-hemorrhage-syndrome-due-to-leptospira-infection-transmitted-by-pet-rat
#10
Bernd Ludwig, Viviane Zotzmann, Christoph Bode, Dawid L Staudacher, Stefan Zschiedrich
Human infection with Leptospira interrogans can be life-threatening. Multiple organ involvement frequently presents with liver and kidney failure, less commonly including severe hemolysis and pulmonary hemorrhage syndrome. Here, we present a fulminant case of leptospirosis presenting with hemolysis and pulmonary hemorrhage. A formerly healthy 34 year old patient presented to a rural hospital with dyspnea and hemoptysis after a week of influenza-like symptoms. Initial assessment revealed severe sepsis, acute kidney failure and severe hemolysis...
2017: IDCases
https://www.readbyqxmd.com/read/28489846/-gastrointestinal-bleeding-and-acute-hepatic-failure-by-leptospirosis-an-entity-that-should-not-be-forgotten
#11
Carlos Alventosa Mateu, Lydia Plana Campos, Laura Larrey Ruíz, Raquel Acedo Mayordomo, Laura Sanchís Artero, Laura Peño Muñoz, Paola Concepción Núñez Martínez, Génesis Aurora Castillo López, Mercedes Latorre Sánchez, Juan José Urquijo Ponce, Moisés Diago Madrid, Javier Sempere García-Argüelles
Leptospirosis disease is caused by the spirochete Leptospira. It is a worldwide distribution zoonosis, with predominance in the tropics. In Spain, it is not frequent but some cases have been noticed especially in humid areas surrounded by rivers, lakes or ponds, such as Catalonia, Andalucia or the Valencian Community. It is transmitted by a variety of animals such as cows or rats, that are infected either by direct contact with these animals or their urine, or indirectly by consuming or being in contact with water contaminated by their urine...
January 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28487178/comparison-between-generalized-linear-modelling-and-additive-bayesian-network-identification-of-factors-associated-with-the-incidence-of-antibodies-against-leptospira-interrogans-sv-pomona-in-meat-workers-in-new-zealand
#12
M Pittavino, A Dreyfus, C Heuer, J Benschop, P Wilson, J Collins-Emerson, P R Torgerson, R Furrer
BACKGROUND: Additive Bayesian Network (ABN) is a graphical model which extends Generalized Linear Modelling (GLM) to multiple dependent variables. The present study compares results from GLM with those from ABN analysis used to identify factors associated with Leptospira interrogans sv Pomona (Pomona) infection by exploring the advantages and disadvantages of these two methodologies, to corroborate inferences informing health and safety measures at abattoirs in New Zealand (NZ). METHODOLOGY AND FINDINGS: in a cohort study in four sheep slaughtering abattoirs in NZ, sera were collected twice a year from 384 meat workers and tested by Microscopic Agglutination with a 91% sensitivity and 94% specificity for Pomona...
May 6, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28482843/sero-prevalence-of-specific-leptospira-serovars-in-fattening-pigs-from-5-provinces-in-vietnam
#13
Hu Suk Lee, Nguyen Viet Khong, Huyen Nguyen Xuan, Vuong Bui Nghia, Hung Nguyen-Viet, Delia Grace
BACKGROUND: Leptospirosis is a zoonotic bacterial disease with a worldwide distribution. In Vietnam, leptospirosis is considered endemic. In pigs, leptospirosis can result in reproductive problems (such as abortion and infertility) which lead to economic loss. In addition, transmission to people presents a public health risk. In Vietnam, few national studies have been conducted on sero-prevalence of leptospirosis in pigs. The main objective of this study was to evaluate the sero-prevalence and incidence of presumptive infective leptospira serovars in fattening pigs from 5 provinces in Vietnam...
May 8, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28475453/presence-of-antibodies-to-leptospira-spp-in-black-tailed-prairie-dogs-cynomys-ludovicianus-and-beavers-castor-canadensis-in-northwestern-mexico
#14
Andrés M López-Pérez, Gerardo Carreón-Arroyo, Daniel Atilano, Ana L Vigueras-Galván, Carlos Valdez, Daniel Toyos, Daniel Mendizabal, Jonathan López-Islas, Gerardo Suzán
Leptospires are widespread spirochete bacteria that infect mammals, including rodents and humans. We investigated the presence of Leptospira antibodies in two species of rodents from San Pedro River Basin (SPRB) in northwestern Mexico as part of the black-tailed prairie dog ( Cynomys ludovicianus ) monitoring plan and the North American beaver ( Castor canadensis ) reintroduction program. We sampled a total of 26 black-tailed prairie dogs and three beavers during October-November 2015. We detected antibodies against Leptospira spp...
May 5, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28472618/plurality-of-leptospira-strains-on-slaughtered-animals-suggest-a-broader-concept-of-adaptability-of-leptospires-to-cattle
#15
Priscila S Pinto, Cristiane Pestana, Marco A Medeiros, Walter Lilenbaum
Leptospirosis in bovines is in majority determined by the host-adapted serovars, mainly Hardjo (types Hardjoprajitno and Hardjobovis), that belong to the serogroup Sejroe. Members of other serogroups as Pomona and Tarassovi have been eventually reported, mainly when outbreaks occurs. Nevertheless, the real role of other strains (non-Hardjo) on determining disease or being transmitted by cattle free of apparent clinical signs of acute infection remains to be elucidated. In that context, the aim of the present study was to investigate the hypothesis that strains of serovars/serogroups other than Hardjo may also be maintained and shed by cattle free of clinical signs...
May 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28470362/pathogen-exposure-in-cattle-at-the-livestock-wildlife-interface
#16
Malavika Rajeev, Mathew Mutinda, Vanessa O Ezenwa
Land use is an important driver of variation in human infectious disease risk, but less is known about how land use affects disease risk in livestock. To understand how land use is associated with disease risk in livestock, we examined patterns of pathogen exposure in cattle across two livestock ranching systems in rural Kenya: private ranches with low- to medium-intensity cattle production and high wildlife densities, and group ranches with high-intensity cattle production and low wildlife densities. We surveyed cattle from six ranches for three pathogens: Brucella spp...
May 3, 2017: EcoHealth
https://www.readbyqxmd.com/read/28468604/simultaneous-detection-of-chikungunya-virus-dengue-virus-and-human-pathogenic-leptospira-genomes-using-a-multiplex-taqman%C3%A2-assay
#17
Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque, Marie-Christine Jaffar-Bandjee
BACKGROUND: In 2005-2006 a major epidemics of Chikungunya disease occurred in South-West Indian Ocean islands. In Reunion Island, the magnitude of Chikungunya infection related symptoms was high and with over 38% of serological prevalence in the population. This epidemics illustrated the potential threat of emerging arboviral diseases for inhabitants of Reunion Island and elsewhere since vectors are worldwide distributed. A sentinel surveillance network was set-up to detect emerging pathogens associated with fever over 38 °C and in the absence of known etiologic causes...
May 3, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28466955/-epidemiology-and-prevention-of-leptospirosis-in-dogs
#18
Michèle Bergmann, Julia-Rebecca Llewellyn, Katrin Hartmann
Leptospirosis is a zoonotic disease with increasing prevalence in dogs and humans. The various Leptospira serovars display different pathogenicity. Even healthy infected dogs can shed leptospires with their urine and thus, represent a risk for humans and other animals. Vaccination is the most important measure for prevention; it not only prevents disease in dogs, but also reduces shedding of leptospires in urine. For comprehensive protection through vaccination, tetravalent vaccines containing serovars of the serogroups relevant in the corresponding region should be used...
May 3, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28459229/acute-encephalitis-as-initial-presentation-of-leptospirosis
#19
Edmond Puca, Joana Majko, Entela Puca, Elda Qyra, Arjet Gega, Pellumb Pipero
Encephalitis is an acute inflammation of the brain matter, very often associated with viral infections, but it can also be caused by non-viral pathogens such as leptospirosis. Leptospirosis is a systemic disease caused by bacteria of the Leptospira genus. Leptospiral infection has a broad spectrum of clinical manifestations ranging from subclinical or mild illness to a fulminant life-threatening illness. In this case report we describe a young patient from Southern Albania with isolated encephalitis caused by Leptospira, where acute encephalitis was the initial presentation of the disease...
April 30, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28452041/cloning-and-characterization-of-the-type-i-baeyer-villiger-monooxygenase-from-leptospira-biflexa
#20
Romina D Ceccoli, Dario A Bianchi, Michael J Fink, Marko D Mihovilovic, Daniela V Rial
Baeyer-Villiger monooxygenases are recognized by their ability and high selectivity as oxidative biocatalysts for the generation of esters or lactones using ketones as starting materials. These enzymes represent valuable tools for biooxidative syntheses since they can catalyze reactions that otherwise involve strong oxidative reagents. In this work, we present a novel enzyme, the Type I Baeyer-Villiger monooxygenase from Leptospira biflexa. This protein is phylogenetically distant from other well-characterized BVMOs...
December 2017: AMB Express
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