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https://www.readbyqxmd.com/read/28544243/evening-versus-morning-dosing-regimen-drug-therapy-for-chronic-kidney-disease-patients-with-hypertension-in-blood-pressure-patterns-a-systematic-review-and-meta-analysis
#1
Caixia Wang, Yuqiu Ye, Chunyong Liu, Yongming Zhou, Linsheng Lv, Cailian Cheng, Shaomin Li, Tanqi Lou, Xun Liu
BACKGROUND: Evening dosing regimen drug therapy on blood pressure (BP) control is used widely, but its clinical benefits and preservation or re-establishment of normal 24-hour BP dipping pattern in chronic kidney disease (CKD) patients is not known. AIMS: To investigate the effect of evening dosing regimen of antihypertensive drugs on blood pressure patterns to CKD patients with hypertension. METHODS: We did a systematic review by searching PUBMED, EMBASE, ASN-ONLINE, the Cochrane Library and the reference lists of relevant articles of published papers...
May 24, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28471650/food-quality-monitor-paper-based-plasmonic-sensors-prepared-through-reversal-nanoimprinting-for-rapid-detection-of-biogenic-amine-odorants
#2
Shih-Yu Tseng, Szu-Ying Li, Shang-Yi Yi, Aileen Y Sun, Dong-Yu Gao, Dehui Wan
This paper describes the fabrication of paper-based plasmonic refractometric sensors through the embedding of metal nanoparticles (NPs) onto flexible papers using reversal nanoimprint lithography. The NP-embedded papers can serve as gas sensors for the detection of volatile biogenic amines (BAs) released from spoiled food. Commercial inkjet papers were employed as sensor substrates-their high reflectance (>80%) and smooth surfaces (roughness: ca. 4.9 nm) providing significant optical signals for reflection-mode plasmonic refractometric sensing and high particle transfer efficiency, respectively; in addition, because inkjet papers have lightweight and are burnable and flexible, they are especially suitable for developing portable, disposable, cost-effective, eco-friendly sensing platforms...
May 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28451152/gradient-doping-of-phosphorus-in-fe2o3-nanoarray-photoanodes-for-enhanced-charge-separation
#3
Zhibin Luo, Chengcheng Li, Shanshan Liu, Tuo Wang, Jinlong Gong
Hematite (α-Fe2O3) is a promising candidate for solar-to-hydrogen energy conversion. However, the low carrier mobility and extremely high charge recombination rate limit the practical application of hematite in solar water splitting. This paper describes the fabrication of a Fe2O3 photoanode with gradient incorporation of phosphorus (P) employing a facile dipping and annealing method to improve the charge separation for enhanced photoelectrochemical water oxidation. This gradient P incorporation increases the width of band bending over a large region in Fe2O3, which is crucial for promoting the charge separation efficiency in the bulk...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28407712/relationship-between-young-s-modulus-and-film-architecture-in-cellulose-nanofibril-based-multilayered-thin-films
#4
Firas Azzam, Laurent Chaunier, Céline Moreau, Denis Lourdin, Patricia Bertoncini, Bernard Cathala
Young's moduli of cellulose nanofibril (CNF)-poly(allylamine hydrochloride) (PAH) multilayered thin films were measured using strain-induced elastic buckling instability for mechanical measurements (SIEBIMM) and the quantitative nanomechanical mapping technique (PF-QNM). To establish the relationship between structure and mechanical properties, three types of films with various architectures were built using the layer-by-layer method by changing the ionic strength of the dipping solution. Both methods demonstrate that the architecture of a film has a strong impact on its mechanical properties even though the film has similar cellulose content, emphasizing the role of the architecture...
April 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28381465/associations-of-blood-pressure-dipping-patterns-with-left-ventricular-mass-and-left-ventricular-hypertrophy-in-blacks-the-jackson-heart-study
#5
Marwah Abdalla, Melissa C Caughey, Rikki M Tanner, John N Booth, Keith M Diaz, D Edmund Anstey, Mario Sims, Joseph Ravenell, Paul Muntner, Anthony J Viera, Daichi Shimbo
BACKGROUND: Abnormal diurnal blood pressure (BP), including nondipping patterns, assessed using ambulatory BP monitoring, have been associated with increased cardiovascular risk among white and Asian adults. We examined the associations of BP dipping patterns (dipping, nondipping, and reverse dipping) with cardiovascular target organ damage (left ventricular mass index and left ventricular hypertrophy), among participants from the Jackson Heart Study, an exclusively black population-based cohort...
April 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320765/effect-of-uric-acid-lowering-on-renin-angiotensin-system-activation-and-ambulatory-bp-a-randomized-controlled-trial
#6
Ciaran J McMullan, Lea Borgi, Naomi Fisher, Gary Curhan, John Forman
BACKGROUND AND OBJECTIVES: Higher serum uric acid levels, even within the reference range, are strongly associated with increased activity of the renin-angiotensin system (RAS) and risk of incident hypertension. However, the effect of lowering serum uric acid on RAS activity in humans is unknown, although the data that lowering serum uric acid can reduce BP are conflicting. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a double-blind placebo-controlled trial conducted from 2011 to 2015, we randomly assigned 149 overweight or obese adults with serum uric acid ≥5...
March 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28266630/cluster-analysis-a-new-approach-for-identification-of-underlying-risk-factors-for-coronary-artery-disease-in-essential-hypertensive-patients
#7
Qi Guo, Xiaoni Lu, Ya Gao, Jingjing Zhang, Bin Yan, Dan Su, Anqi Song, Xi Zhao, Gang Wang
Grading of essential hypertension according to blood pressure (BP) level may not adequately reflect clinical heterogeneity of hypertensive patients. This study was carried out to explore clinical phenotypes in essential hypertensive patients using cluster analysis. This study recruited 513 hypertensive patients and evaluated BP variations with ambulatory blood pressure monitoring. Four distinct hypertension groups were identified using cluster analysis: (1) younger male smokers with relatively high BP had the most severe carotid plaque thickness but no coronary artery disease (CAD); (2) older women with relatively low diastolic BP had more diabetes; (3) non-smokers with a low systolic BP level had neither diabetes nor CAD; (4) hypertensive patients with BP reverse dipping were most likely to have CAD but had least severe carotid plaque thickness...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28236344/integration-of-high-risk-human-papillomavirus-into-cellular-cancer-related-genes-in-head-and-neck-cancer-cell-lines
#8
Heather M Walline, Christine M Goudsmit, Jonathan B McHugh, Alice L Tang, John H Owen, Bin T Teh, Erin McKean, Thomas W Glover, Martin P Graham, Mark E Prince, Douglas B Chepeha, Steven B Chinn, Robert L Ferris, Susanne M Gollin, Thomas K Hoffmann, Henning Bier, Ruud Brakenhoff, Carol R Bradford, Thomas E Carey
BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal cancer is generally associated with excellent response to therapy, but some HPV-positive tumors progress despite aggressive therapy. The purpose of this study was to evaluate viral oncogene expression and viral integration sites in HPV16- and HPV18-positive squamous cell carcinoma lines. METHODS: E6/E7 alternate transcripts were assessed by reverse transcriptase-polymerase chain reaction (RT-PCR). Detection of integrated papillomavirus sequences (DIPS-PCR) and sequencing identified viral insertion sites and affected host genes...
May 2017: Head & Neck
https://www.readbyqxmd.com/read/28231683/the-adverse-effects-of-exercise-and-supraphysiological-dose-of-testosterone-enanthate-te-on-exploratory-activity-in-elevated-plus-maze-epm-test-indications-for-using-total-exploratory-activity-tea-as-a-new-parameter-for-ex
#9
Dragica Selakovic, Jovana Joksimovic, Dragan Obradovic, Dragan Milovanovic, Milos Djuric, Gvozden Rosic
OBJECTIVES: The aim of this study was the estimation of effects induced by chronic administration of supraphysiological dose of TE and prolonged exercise in male rats on anxiety levels (alterations in exploratory activity patterns in EPM). MATERIAL AND METHODS: Two sedentary (control - C and testosterone-enanthate - T) and two exercise (exercise - E and testosterone-enanthate plus exercise - T+E) groups (n=32) underwent adequate protocols - the swimming protocol (1 h/day) and TE (20 mg/kg/w, s...
October 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28183366/effects-of-almond-consumption-on-the-post-lunch-dip-and-long-term-cognitive-function-in-energy-restricted-overweight-and-obese-adults
#10
RANDOMIZED CONTROLLED TRIAL
Jaapna Dhillon, Sze-Yen Tan, Richard D Mattes
The post-lunch dip in cognition is a well-established phenomenon of decreased alertness, memory and vigilance after lunch consumption. Lunch composition reportedly influences the post-lunch dip. Moreover, dieting is associated with cognitive function impairments. The negative effects of dieting have been reversed with nut-supplemented diets. The aims of this study were to (1) evaluate the acute effect of an almond-enriched high-fat lunch or high-carbohydrate lunch on the post-lunch decline in cognitive function, and (2) evaluate the effects of chronic almond consumption as part of an energy-restricted diet on the memory and attention domains of cognitive function...
February 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28163096/paracetamol-effect-of-early-exposure-on-neurotransmission-spatial-memory-and-motor-performance-in-rats
#11
Kamilla Blecharz-Klin, Agnieszka Piechal, Katarzyna Jawna-Zboińska, Justyna Pyrzanowska, Adriana Wawer, Ilona Joniec-Maciejak, Ewa Widy-Tyszkiewicz
In the present study we examined the effect of prenatal and early life paracetamol exposure on neurotransmission and its behavioural manifestation in rat male pups. In order to assess the ability of spatial learning and memory consolidation and the level of physical and exploratory activity we conducted a series of behavioural tests: Staircase Test, Hole Board Test and Water Maze. The concentrations of monoamines, metabolites and amino acids were determined using High Performance Liquid Chromatography in the prefrontal cortex, hippocampus and striatum...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28117539/blood-pressure-regulation-determined-by-ambulatory-blood-pressure-profiles-in-children-and-adolescents-with-type-1-diabetes-mellitus-impact-on-diabetic-complications
#12
A Dost, S Bechtold-Dalla Pozza, E Bollow, R Kovacic, P Vogel, L Feldhahn, K O Schwab, R W Holl
BACKGROUND: The combination of high blood pressure and hyperglycemia contributes to the development of diabetic complications. Ambulatory monitoring of blood pressure (ABPM) is seen as standard to assess blood pressure (BP) regulation. OBJECTIVE: We evaluated 24-hour BP regulation in 3529 children with type 1 diabetes, representing 5.6% of the patients <20 years of age documented in the DPV registry, and studied the influence of BP parameters including pulse pressure (PP) and blood pressure variability (BPV) on microalbuminuria (MA) and diabetic retinopathy (DR)...
January 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28106394/green-to-red-electrochromic-fe-ii-metallo-supramolecular-polyelectrolytes-self-assembled-from-fluorescent-2-6-bis-2-pyridyl-pyrimidine-bithiophene
#13
Sandesh Pai, Michael Moos, Maximilian H Schreck, Christoph Lambert, Dirk G Kurth
The structure and properties of metallo-supramolecular polyelectrolytes (MEPEs) self-assembled from rigid 2,6-bis(2-pyridyl)pyrimidine and the metal ions Fe(II) and Co(II) are presented. While FeL1-MEPE (L1 = 1,4-bis[2,6-bis(2-pyridyl)pyrimidin-4-yl]benzene) is deep blue, FeL2- and CoL2-MEPE (L2 = 5,5'-bis[2,6-bis(2-pyridyl)pyrimidin-4-yl]-2,2'-bithiophene) are intense green and red in color, respectively. These novel MEPEs display a high extinction coefficient and solvatochromism. Ligand L2 shows a high absolute fluorescence quantum yield (Φf = 82%)...
January 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28013220/from-the-cover-potentiation-of-drug-induced-phospholipidosis-in-vitro-through-peglyated-graphene-oxide-as-the-nanocarrier
#14
Liecheng Yang, Xiaoyan Zhong, Qian Li, Xihui Zhang, Yangyun Wang, Kai Yang, Leshuai W Zhang
Cationic amphiphilic drugs (CADs) are small molecules that can induce phospholipidosis (PLD), causing the intracellular accumulation of phospholipid in the lamellar bodies. Nanotechnology based drug delivery systems have been used widely, while it is unknown if drug-induced PLD (DIP) can be potentiated through drug retention by indigestible nanocarriers. Due to the high drug loading capacity of graphene, we investigated if PEGylated graphene oxide (PEG-GO) loaded with CAD could potentiate DIP. Tamoxifen induced the accumulation of NBD-PE, a fluorescence labeled phospholipid in human hepatoma HepG2 cells, while PEG-GO loaded with tamoxifen (PEG-GO/tamoxifen) further potentiated PLD...
March 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27926690/changes-of-blood-pressure-patterns-and-target-organ-damage-in-patients-with-chronic-kidney-disease-results-of-the-aprodite-2-study
#15
Ran-Hui Cha, Hajeong Lee, Jung Pyo Lee, Eunjeong Kang, Young Rim Song, Yon Su Kim, Sung Gyun Kim
OBJECTIVE: Blood pressure (BP) control is the most established practice for preventing the progression of chronic kidney disease (CKD). We examined the BP control and nocturnal dipping pattern changes in hypertensive patients with CKD and their effects on target organ damages. METHODS: We recruited 378 hypertensive CKD patients from four centers in Korea. The patients underwent clinic and ambulatory BP monitoring at the time of enrollment and 1 year later. RESULTS: The BP control states at the two time points were as follows: true controlled (16...
March 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27916260/arsenic-solid-phase-speciation-and-reversible-binding-in-long-term-contaminated-soils
#16
M S Rahman, M W Clark, L H Yee, M J Comarmond, T E Payne, P Kappen, L Mokhber-Shahin
Historic arsenic contamination of soils occurs throughout the world from mining, industrial and agricultural activities. In Australia, the control of cattle ticks using arsenicals from the late 19th to mid 20th century has led to some 1600 contaminated sites in northern New South Wales. The effect of aging in As-mobility in two dip-site soil types, ferralitic and sandy soils, are investigated utilizing isotopic exchange techniques, and synchrotron X-ray adsorption spectroscopy (XAS). Findings show that historic soil arsenic is highly bound to the soils with >90% irreversibly bound...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27901645/fenestrated-adipofascial-reverse-flap-a-modified-technique-for-the-reconstruction-of-fingertip-amputations
#17
Francesco Idone, Andrea Sisti, Juri Tassinari, Giuseppe Nisi
AIMS OF THE STUDY: Fingertip injuries can be treated in different ways, including shortening with primary closure, skin graft, and local or distant flaps. Several local flaps for the reconstruction of the amputated fingertip were described. We present our experience with a new concept of homodigital adipofascial reverse flap that avoids the second surgical stage and allows a complete and anatomically perfect reconstruction of nail bed, with preservation of the nail lamina. MATERIALS AND METHODS: Between March 2014 and February 2015, five patients with digital amputations (distally to the nail matrix) were treated using the Fenestrated Adipofascial Reverse (F...
November 30, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27875953/management-of-hypertension-in-patients-with-chronic-kidney-disease-in-asia
#18
Qi-Fang Huang, Satoshi Hoshide, Hao-Min Cheng, Sungha Park, Chang-Gyu Park, Chen-Huan Chen, Kazuomi Kario, Ji-Guang Wang
Hypertension is both a cause and consequence of chronic kidney disease (CKD). According to the Chinese national survey in 2007-2010, the prevalence of CKD was much higher in hypertensive patients (18.9%, n=16,691) than in the overall population sample (10.8%, n=47,204). CKD in hypertension confers risks to the kidneys as well as other organs. Probably because of high dietary salt intake, Asian hypertensive patients with CKD show high prevalence of non-dipping and reversed dipping blood pressure pattern, and may have even higher risks of cardiovascular disease...
2016: Current Hypertension Reviews
https://www.readbyqxmd.com/read/27855748/ambulatory-blood-pressure-monitoring-in-chinese-patients-with-obstructive-sleep-apnea
#19
Yan Ma, Shuchen Sun, Chung-Kang Peng, Yeming Fang, Robert J Thomas
STUDY OBJECTIVES: Nocturnal blood pressure (BP) dipping in patients with obstructive sleep apnea (OSA) has not yet been well investigated in Chinese patients, in whom the relationship of OSA and body mass index (BMI) is weaker than that in Caucasians. The aim of this study was to evaluate the BP profile, and the relationships between nocturnal BP and the severity of OSA, in Chinese patients. METHODS: Consecutive Chinese adult outpatients with suspected OSA had overnight polysomnography (PSG), office BP, and 24-h ambulatory BP monitoring (ABPM)...
March 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27853909/not-all-drug-induced-parkinsonism-are-the-same-the-effect-of-drug-class-on-motor-phenotype
#20
Renato P Munhoz, Delcio Bertucci Filho, Hélio A G Teive
Drug-induced parkinsonism (DIP) is classically described as acute/subacute, bilateral symmetric syndrome in which tremor is infrequent compared to Parkinson's disease. Most DIP cases are caused by classic (CN) and second-generation neuroleptics (SN), and calcium channel blockers (CCB). We evaluated potentially distinctive demographic and clinical features in DIP among different drug classes. This was a prospective study of reversible DIP related to single selected drugs on each class. Baseline assessment included demographic, clinical data, and scales for staging, severity of motor signs of parkinsonism, tremor, and other involuntary movements...
February 2017: Neurological Sciences
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