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https://www.readbyqxmd.com/read/28821148/a-pectic-polysaccharide-from-ligusticum-chuanxiong-promotes-intestine-antioxidant-defense-in-aged-mice
#1
Chao Huang, Xiyue Cao, Xingfu Chen, Yuping Fu, Yingguo Zhu, Zhengli Chen, Qihui Luo, Lixia Li, Xu Song, Renyong Jia, Zhongqiong Yin, Bin Feng, Yuanfeng Zou
The extensive prospects of polysaccharides in medicine and pharmaceuticals have elicited much interest. Ligusticum chuanxiong polysaccharides, previously extracted as neutral polysaccharides, exhibit antioxidant, anticancer, andantibacterial capacities in vitro. Here we show one pectic polysaccharide extracted from rhizome of L. chuanxiong(LCP-II-I). Structural analysis indicated its long homogalacturonan region is interrupted by rhamnogalacturonan type I, with arabinan and arabinogalactan type I as side chains...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821084/green-synthesis-of-oriented-xanthan-gum-graphene-oxide-hybrid-aerogels-for-water-purification
#2
Shunli Liu, Fang Yao, Olayinka Oderinde, Zhihong Zhang, Guodong Fu
Three-dimensional xanthan gum (XG)/graphene oxide (GO) hybrid aerogels were fabricated by ice crystal templating without using chemical modifiers. The hybrid aerogels were prepared by the stirring of xanthan gum-graphene oxide hybrid solution, followed by freezing at low temperature and finally by freeze-drying. The whole preparation could be completed within 12h without producing any contamination and thus considered a fast, simple, economical, and green method for aerogel fabrication. XG/GO hybrid aerogels possessed different hierarchical pore structures because of various freezing temperatures...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821078/fabrication-of-magnetic-particles-imprinted-cellulose-based-biocomposites-for-chromium-vi-removal
#3
Soodamani Periyasamy, Venkatrajan Gopalakannan, Natrayasamy Viswanathan
The present study was focused on Cr(VI) removal using eco-friendly materials like cellulose (Cel), hydrotalcite (HT), hydroxyapatite (HAp) and their composite forms. The cellulose/hydrotalcite (CelHT) and cellulose/hydroxyapatite (CelHAp) composites were synthesized by dispersing HT and HAp individually in cellulose polymeric matrix. To enhance the Cr(VI) sorption capacity (SC) and easy separation, cellulose supported magnetic composites namely iron-oxide coated cellulose/hydrotalcite (Fe3O4@CelHT) and cellulose/hydroxyapatite (Fe3O4@CelHAp) were synthesized by in situ fabrication method...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820950/combined-aerobic-and-resistance-exercise-training-for-improving-reproductive-function-in-infertile-men-a-randomized-controlled-trial
#4
Behzad Hajizadeh Maleki, Bakhtyar Tartibian
This randomized controlled trial was conducted to examine the effects of 24 weeks of combined aerobic and resistance exercise training on seminal markers of inflammation and oxidative stress as well as markers of male reproductive function and reproductive performance in infertile patients. Of a total of 1296 infertile patients (aged 25-40 years) who were screened, 556 were randomly assigned to exercise (EX, n = 278) and non-exercise (NON-EX, n = 278) groups. Semen samples were taken before, 12 and 24 weeks as well as 7 and 30 days post intervention...
August 18, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28820572/on-the-functionality-selection-principle-for-high-voltage-lithium-ion-battery-electrolyte-additives
#5
Chi-Cheung Su, Meinan He, Cameron Peebles, Li Zeng, Adam Tornheim, Chen Liao, Lu Zhang, Jie Wang, Yan Wang, Zhengcheng Zhang
A new class of electrolyte additives based on cyclic fluorinated phosphate esters was rationally desgined and identified as being able to stabilize the surface of LiNi0.5Mn0.3Co0.2O2 (NMC532) cathode when cycled at potentials higher than 4.6 V vs. Li+/Li. Cyclic fluorinated phosphates were designed to incorporate functionalities of various existing additives to maximize their utilization. The synthesis and characterization of these new additives are described and their electrochemical performance in a NMC532/graphite cell cycled between 4...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28820222/quasi-zero-dimensional-cobalt-doped-ceo2-dots-on-pd-catalysts-for-alcohol-electro-oxidation-with-enhanced-poisoning-tolerance
#6
Qiang Tan, Haiyan Zhu, Shengwu Guo, Yuanzhen Chen, Tao Jiang, Chengyong Shu, Shaokun Chong, Benjamin Hultman, Yongning Liu, Gang Wu
Deactivation of an anode catalyst resulting from the poisoning of COad-like intermediates is one of the major problems for methanol and ethanol electro-oxidation reactions (MOR & EOR), and remains a grand challenge towards achieving high performance for direct alcohol fuel cells (DAFCs). Herein, we report a new approach for the preparation of ultrafine cobalt-doped CeO2 dots (Co-CeO2, d = 3.6 nm), which can be an effective anti-poisoning promoter for Pd catalysts towards MOR and EOR in alkaline media. Compared to Pd/CeO2 and pure Pd, the hybrid Pd/Co-CeO2 nanocomposite catalyst exhibited a much enhanced activity and remarkable anti-poisoning ability for both MOR and EOR...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28819969/a-fast-and-universal-approach-to-encapsulating-transition-bimetal-oxide-nanoparticles-in-amorphous-carbon-nanotubes-under-atmospheric-environment-based-on-marangoni-effect
#7
Shuoyu Li, Yuyi Liu, Peisheng Guo, Chengxin Wang
Transitionmetal oxides nanoparticles capsuled in amorphous carbon nanotubes (ACNTs) are attractive anode materials of lithium ion batteries (LIBs). Here we firstly designed a fast and universal method with a hydromechanics conception which is called Marangoni flow to fabricating transition bimetal oxides (TBOs) in ACNTs composite with a better electrochemistry performance. Maragoni flows can produce a liquid column with several centimeters high in a tube with one side immersion in the liquid. The key point to induce a Marangoni flow is to make a gradient of the surface tension between the surface and the inside of the solution...
August 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28819666/ph-responsive-prodrug-nanoparticles-based-on-a-sodium-alginate-derivative-for-selective-co-release-of-doxorubicin-and-curcumin-into-tumor-cells
#8
Cheng Gao, Fan Tang, Guiyi Gong, Jianxiang Zhang, Maggie P M Hoi, Simon M Y Lee, Ruibing Wang
In order to realize a combination of chemotherapy and selective drug release into tumor cells, novel pH-sensitive prodrugnanoparticles were designed and prepared via the self-assembly of a synthetic amphiphilic macromolecular prodrug for the selective co-delivery of doxorubicin (Dox) and curcumin (Cur). Dox was covalently conjugated to the oxidized sodium alginate through a Schiff base reaction to produce an amphiphilic macromolecular prodrug, and the prodrug was subsequently self-assembled into nanoparticles (Dox-NPs) in an aqueous solution, which were responsive to the acidic environment in tumor cells...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28819542/mulberry-fruit-extract-affords-protection-against-ethyl-carbamate-induced-cytotoxicity-and-oxidative-stress
#9
Wei Chen, Yuting Li, Tao Bao, Vemana Gowd
Ethyl carbamate (EC) is a food and environmental toxicant and is a cause of concern for human exposure. Several studies indicated that EC-induced toxicity was associated with oxidative stress. Mulberry fruits are reported to have a wide range of bioactive compounds and pharmacological activities. The present study was therefore aimed to investigate the protective property of mulberry fruit extract (MFE) on EC-induced cytotoxicity and oxidative stress. Chemical composition analysis showed that total phenolic content and total flavonoid content in MFE were 502...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28819274/distinct-carbon-sources-affect-structural-and-functional-maturation-of-cardiomyocytes-derived-from-human-pluripotent-stem-cells
#10
Cláudia Correia, Alexey Koshkin, Patrícia Duarte, Dongjian Hu, Ana Teixeira, Ibrahim Domian, Margarida Serra, Paula M Alves
The immature phenotype of human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) constrains their potential in cell therapy and drug testing. In this study, we report that shifting hPSC-CMs from glucose-containing to galactose- and fatty acid-containing medium promotes their fast maturation into adult-like CMs with higher oxidative metabolism, transcriptional signatures closer to those of adult ventricular tissue, higher myofibril density and alignment, improved calcium handling, enhanced contractility, and more physiological action potential kinetics...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819266/amalaki-rasayana-a-traditional-indian-drug-enhances-cardiac-mitochondrial-and-contractile-functions-and-improves-cardiac-function-in-rats-with-hypertrophy
#11
Vikas Kumar, Kumar A Aneesh, K Kshemada, Kumar G S Ajith, Raj S S Binil, Neha Deora, G Sanjay, A Jaleel, T S Muraleedharan, E M Anandan, R S Mony, M S Valiathan, Kumar T R Santhosh, C C Kartha
We evaluated the cardioprotective effect of Amalaki Rasayana (AR), a rejuvenating Ayurvedic drug prepared from Phyllanthus emblica fruits in the reversal of remodeling changes in pressure overload left ventricular cardiac hypertrophy (LVH) and age-associated cardiac dysfunction in male Wistar rats. Six groups (aging groups) of 3 months old animals were given either AR or ghee and honey (GH) orally; seventh group was untreated. Ascending aorta was constricted using titanium clips in 3 months old rats (N = 24; AC groups) and after 6 months, AR or GH was given for further 12 months to two groups; one group was untreated...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819000/hypoxia-induced-myocardial-regeneration
#12
Wataru Kimura, Yuji Nakada, Hesham A Sadek
The underlying cause of systolic heart failure is the inability of the adult mammalian heart to regenerate damaged myocardium. In contrast, some vertebrate species and immature mammals are capable of full cardiac regeneration following multiple types of injury through cardiomyocyte proliferation. Little is known about what distinguishes proliferative cardiomyocytes from terminally differentiated, non-proliferative cardiomyocytes. Recently, several reports have suggested that oxygen metabolism and oxidative stress play a pivotal role in regulating the proliferative capacity of mammalian cardiomyocytes...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28818685/ethyl-carbamate-induces-cell-death-through-its-effects-on-multiple-metabolic-pathways
#13
Huichang Liu, Bo Cui, Yi Xu, Chaoyang Hu, Ying Liu, Guorun Qu, Dawei Li, Yongning Wu, Dabing Zhang, Sheng Quan, Jianxin Shi
Ethyl carbamate (EC), a multisite carcinogenic chemical causing tumors in various animal species, is probably carcinogenic to humans. However, information about the possible carcinogenic and toxicological effects of EC in humans is quite limited. Because EC is found in many dietary foods (such as fermented foods) and tobacco and its products, and exposure of humans to EC often occurs inevitably, its toxicological effects in humans need to be studied. This study was conducted to understand the metabolomic and transcriptomic changes in human hepatocellular carcinoma cells (HepG2) exposed to 100 mM EC for short term (4 h) and long term (12 h) period, respectively...
August 14, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28818066/hepatoprotective-and-antioxidant-effects-of-single-clove-garlic-against-ccl4-induced-hepatic-damage-in-rabbits
#14
Khalid Mohammed Naji, Elham Shukri Al-Shaibani, Fatima A Alhadi, Safa'a Abdulrzaq Al-Soudi, Myrene R D'souza
BACKGROUND: The increase in demand and consumption of single clove garlic or 'Solo garlic' (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antioxidant activities, oxidant-scavenging efficiency and preventive effects of SCG (single clove garlic) and MCG (multi clove garlic) on CCl4-induced acute hepatotoxicity in male rabbits. METHODS: For this purpose, rabbits were orally administered with 3 ml of CCl4 /kg of body weight, followed by 0...
August 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28817808/ppar%C3%AE-agonist-stimulated-angiogenesis-by-improving-endothelial-precursor-cell-function-via-a-nlrp3-inflammasome-pathway
#15
Yaping Deng, Xue Han, Zheng Yao, Yuannan Sun, Jiawen Yu, Jian Cai, Guofei Ren, Guojun Jiang, Feng Han
BACKGROUND: Impaired wound healing is a common complication of diabetes and is the leading cause of lower extremity amputation. Treatment with fenofibrate, a peroxisome proliferators-activated receptor α (PPARα) agonist, was associated with a lower risk of amputations, particularly minor amputations without known large-vessel diseases, probably through non-lipid mechanisms. The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice...
August 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28817487/inhibiting-protein-tyrosine-phosphatase-1b-to-improve-regenerative-functions-of-endothelial-cells
#16
Yuan Wang, Feng Yan, Wenjing Zhang, Shu Pang, Fan Jiang
Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin receptor- and vascular endothelial growth factor receptor-dependent signalings in endothelial cells. Genetic or pharmacological inhibition of PTP1B has been shown to enhance endothelial cell proliferation and migration, and increase nitric oxide production. In vivo, inhibiting PTP1B can reverse endothelial dysfunction, promote angiogenesis, and accelerate wound healing. Intense research is currently continuing in an effort to discover novel selective PTP1B inhibitors, primarily for treating insulin resistance...
August 4, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28817290/air-stable-porous-fe2n-encapsulated-in-carbon-microboxes-with-high-volumetric-lithium-storage-capacity-and-long-cycle-life
#17
Yifan Dong, Bingliang Wang, Kangning Zhao, Yanhao Yu, Xudong Wang, Liqiang Mai, Song Jin
The development of inexpensive electrode materials with high volumetric capacity and long cycle-life is a central issue for large-scale lithium-ion batteries. Here, we report a nanostructured porous Fe2N anode fully encapsulated in carbon microboxes (Fe2N@C) prepared through a facile confined anion conversion method. The resulting carbon microboxes could not only protect the air-sensitive Fe2N from oxidation, but also retain thin and stable SEI layer. The appropriate internal voids in the Fe2N cubes help to release the volume expansion during lithiation/delithiation processes and Fe2N is kept inside the carbon microboxes without breaking the shell, resulting in a very low electrode volume expansion (the electrode thickness variation upon lithiation is ~9%)...
August 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28816057/mitochondrial-complex-i-reversible-s-nitrosation-improves-bioenergetics-and-is-protective-in-parkinson-s-disease
#18
Chiara Milanese, Victor Tapias, Sylvia Gabriels, Silvia Cerri, Giovanna Levandis, Fabio Blandini, Maria Tresini, Sruti Shiva, J Timothy Greenamyre, Mark T Gladwin, Pier G Mastroberardino
AIMS: The present study was designed to explore the neuroprotective potential of inorganic nitrite as a new therapeutic avenue in Parkinson's disease (PD). RESULTS: Administration of inorganic nitrite ameliorates neuropathology in phylogenetically distinct animal models of PD. Beneficial effects are not confined to prophylactic treatment and occur also if nitrite is administered when the pathogenic cascade is already active. Mechanistically, the effect is mediated by both complex I S-nitrosation, which under nitrite administration is favored over formation of other forms of oxidation, and as well as down-stream activation of the antioxidant Nrf2 pathway...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28815865/bone-marrow-and-adipose-mesenchymal-stem-cells-attenuate-cardiac-fibrosis-induced-by-methotrexate-in-rats
#19
Ebtehal Mohammad Fikry, Wedad A Hassan, Amany M Gad
Mesenchymal stem cells (MSCs) are an ideal adult stem cell with capacity for self-renewal and differentiation with an extensive tissue distribution. The present study evaluates the therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) or adipose-derived mesenchymal stem cells (AD-MSCs) against the development of methotrexate (MTX)-induced cardiac fibrosis versus dexamethasone (DEX). Rats were allocated into five groups; group 1, received normal saline orally; group 2, received MTX (14 mg/kg/week for 2 weeks); groups 3 and 4, treated once with 2 × 10(6) cells of MTX + BM-MSCs and MTX + AD-MSCs, respectively; and group 5, MTX + DEX (0...
August 16, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28815615/trans-methylation-reactions-in-plants-focus-on-the-activated-methyl-cycle
#20
Moona Rahikainen, Sara Alegre, Andrea Trotta, Jesús Pascual, Saijaliisa Kangasjärvi
Trans-methylation reactions are vital in basic metabolism, epigenetic regulation, RNA metabolism, and post-translational control of protein function, and therefore fundamental in determining physiological processes in all living organisms. The plant kingdom is additionally characterized by production of secondary metabolites that undergo specific hydroxylation, oxidation and methylation reactions to obtain a wide array of different chemical structures. Increasing research efforts have started to reveal the enzymatic pathways underlying the biosynthesis of complex metabolites in plants...
August 16, 2017: Physiologia Plantarum
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