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https://www.readbyqxmd.com/read/28749594/seizure-activity-per-se-does-not-induce-tissue-damage-markers-in-human-neocortical-focal-epilepsy
#1
Laura Rossini, Rita Garbelli, Vadym Gnatkovsky, Giuseppe Didato, Flavio Villani, Roberto Spreafico, Francesco Deleo, Giorgio Lo Russo, Giovanni Tringali, Francesca Gozzo, Laura Tassi, Marco de Curtis
Objective The contribute of recurring seizures to the progression of epileptogenesis is debated. Seizure-induced brain damage is not conclusively demonstrated both in humans and in animal models of epilepsy. We evaluated the expression of brain injury biomarkers on post-surgical brain tissue obtained from 20 patients with frequent seizures and a long history of drug-resistant focal epilepsy. Methods The expression patterns of specific glial, neuronal and inflammatory molecules was evaluated by immunohistochemistry in the core of type II focal cortical dysplasias (FCD-II), at the FCD boundary (perilesion) and in the adjacent normal-appearing area included in the epileptogenic region...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28748675/does-diabetes-mellitus-influence-carpal-tunnel-syndrome
#2
Yoo Hwan Kim, Kyung Sook Yang, Hanjun Kim, Hung Youl Seok, Jung Hun Lee, Myeong Hun Son, Byung Jo Kim
BACKGROUND AND PURPOSE: Diabetes mellitus (DM) has been proposed as a risk factor for carpal tunnel syndrome (CTS), but this remains controversial. We investigated the association between DM and CTS using both ultrasonography (US) and nerve conduction study (NCS) data. METHODS: We analyzed a prospectively recruited database of neuromuscular US and medical records of subjects who had undergone NCSs and electromyography for symptoms suggestive of CTS. Subjects were assigned to the follow groups: Group I, CTS with DM; Group II, CTS without DM; Group III, no CTS with DM; and Group IV, no CTS without DM...
July 2017: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/28748414/the-effect-of-arterial-curvature-on-blood-flow-in-arterio-venous-fistulae-realistic-geometries-and-pulsatile-flow
#3
L Grechy, F Iori, R W Corbett, W Gedroyc, N Duncan, C G Caro, P E Vincent
Arterio-Venous Fistulae (AVF) are regarded as the "gold standard" method of vascular access for patients with End-Stage Renal Disease (ESRD) who require haemodialysis. However, up to 60% of AVF do not mature, and hence fail, as a result of Intimal Hyperplasia (IH). Unphysiological flow and oxygen transport patterns, associated with the unnatural and often complex geometries of AVF, are believed to be implicated in the development of IH. Previous studies have investigated the effect of arterial curvature on blood flow in AVF using idealized planar AVF configurations and non-pulsatile inflow conditions...
July 26, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28748410/cytotoxic-effect-of-co-expression-of-human-hepatitis-a-virus-3c-protease-and-bifunctional-suicide-protein-fcu1-genes-in-a-bicistronic-vector
#4
Alexey Komissarov, Ilya Demidyuk, Dina Safina, Marina Roschina, Andrey Shubin, Nataliya Lunina, Maria Karaseva, Sergey Kostrov
Recent reports on various cancer models demonstrate a great potential of cytosine deaminase/5-fluorocytosine suicide system in cancer therapy. However, this approach has limited success and its application to patients has not reached the desirable clinical significance. Accordingly, the improvement of this suicide system is an actively developing trend in gene therapy. The purpose of this study was to explore the cytotoxic effect observed after co-expression of hepatitis A virus 3C protease (3C) and yeast cytosine deaminase/uracil phosphoribosyltransferase fusion protein (FCU1) in a bicistronic vector...
July 26, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28748047/immediate-vs-delayed-endosseous-integration-of-maxi-implants-a-torque-removal-animal-study
#5
Hanif Allahbakhshi, Fariborz Vafaee, Mehrdad Lotfazar, Ahmad Hasan Ahangary, Masoumeh Khoshhal, Farnoush Fotovat
Background. Delayed loading is one of the concerns in implant patients. Immediate loading can solve the problem and make patients more satisfied. The present study aimed to compare the removal torque of maxi implants under different loading (immediate and delayed) patterns. Methods. This split-mouth experimental study included 2 dogs. Impressions were made and then all the premolars were extracted under general anesthesia. After a three-month healing period, 3 implants were inserted in each quadrant (a total of 12 implants)...
2017: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/28747589/what-is-the-most-representative-parameter-for-describing-the-size-of-the-atlas-ct-morphometric-analysis-of-the-atlas-with-special-reference-to-atlas-hypoplasia
#6
Hitoshi Yamahata, Hirofumi Hirano, Satoshi Yamaguchi, Masanao Mori, Tadaaki Niiro, Hiroshi Tokimura, Kazunori Arita
The spinal canal diameter (SCD) is one of the most studied factors for the assessment of cervical spinal canal stenosis. The inner anteroposterior diameter (IAP), the SCD, and the cross-sectional area (CSA) of the atlas have been used for the evaluation of the size of the atlas in patients with atlas hypoplasia, a rare form of developmental spinal canal stenosis, however, there is little information on their relationship. The aim of this study was to identify the most useful parameter for depicting the size of the atlas...
July 27, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28747013/estrogen-can-restore-tamoxifen-sensitivity-in-breast-cancer-cells-amidst-the-complex-network-of-resistance
#7
REVIEW
Sepideh Mansouri, Leila Farahmand, Aysooda Hosseinzade, Zahra Eslami-S, Keivan Majidzadeh-A
Breast cancer-related deaths have been on the decline ever since the application of systemic therapies. Chiefly, endocrine therapy, such as Tamoxifen, enhances the survival of estrogen receptor (ER)-positive patients. More than a decade has passed since the introduction of Tamoxifen, however, drug resistance, particularly to Tamoxifen, still remains a major challenge. It has been shown that not only does chronic Tamoxifen exposures induce resistance, but estrogen deprivation can as well. There are two Tamoxifen resistant cell lines, long term estrogen deprived (LTED) cells and cells that have acquired resistance due to long-term exposure to Tamoxifen (Tam-R)...
July 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28746980/single-incision-sling-operations-for-urinary-incontinence-in-women
#8
REVIEW
Arjun Nambiar, June D Cody, Stephen T Jeffery, Patricia Aluko
BACKGROUND: Urinary incontinence has been shown to affect up to 50% of women. Studies in the USA have shown that up to 80% of these women have an element of stress urinary incontinence. This imposes significant health and economic burden on society and the women affected. Colposuspension and now mid-urethral slings have been shown to be effective in treating patients with stress incontinence. However, associated adverse events include bladder and bowel injury, groin pain and haematoma formation...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28746286/harvesting-the-buccal-fat-pad-does-not-result-in-aesthetic-deformity-in-cleft-patients-a-retrospective-analysis
#9
Katelyn G Bennett, Todd E Thurston, Christian J Vercler, Steven J Kasten, Steven R Buchman
BACKGROUND: Buccal fat is often used as a pedicled flap in cleft palate repairs to minimize scarring and fortify tenuous closures. Although many surgeons have adopted this technique, others have remained circumspect because of the concern for subsequent facial asymmetry. METHODS: Patients who underwent cleft palate repair using buccal fat pad flaps for closure between 2007 and 2015 were reviewed. Only patients with unilateral buccal fat pad flaps and three-dimensional photography were included...
August 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28746226/the-use-of-a-dorsal-double-wing-flap-without-skin-grafts-for-congenital-syndactyly-treatment-a-strobe-compliant-study
#10
Yanzhao Dong, Yisheng Wang
Numerous techniques have been developed that use various flaps to treat syndactyly. Skin grafts have often been used to cover remaining surgical defects. The long-term aim of surgery is to find new methods of separating the digits without using skin grafts. This paper describes a new surgical technique for the correction of simple, incomplete, and complete syndactyly. The technique consists of a dorsal double-wing flap to cover the newly created web space and zigzag incisions in the fingers, thus avoiding the use of skin grafts in this space...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746209/pedicled-buccal-fat-pad-for-the-augmentation-of-facial-depression-deformity-a-case-report
#11
Seiji Komatsu, Kou Ikemura, Yoshihiro Kimata
RATIONALE: Tissue augmentation of facial depression deformities can be achieved by volume replacement with autologous fat injection, dermal filler injection, etc. Here, we report a case of tissue augmentation of a facial depression deformity using a pedicled buccal fat pad (BFP). PATIENT CONCERNS: A 64-year-old woman was referred with a chief complaint of facial depression deformity. DIAGNOSES: Her molars had been removed at another hospital 12 years prior to this referral, and the patient suffered from a left cheek depression deformity as a sequela of a postextraction infection...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745555/the-effect-of-rs5758550-on-cyp2d6-2-phenotype-and-formation-of-endoxifen-in-breast-cancer-patients-using-tamoxifen
#12
Anabel B Sanchez-Spitman, Dirk-Jan Ar Moes, Hans Gelderblom, Vincent O Dezentjé, Jesse J Swen, Henk-Jan Guchelaar
AIM: CYP2D6*2 is considered fully active, but it has been suggested that it only happens in the presence of rs5758550. This study aims to elucidate the impact of this enhancer. MATERIALS & METHODS: DNA and blood samples from women enrolled in the CYPTAM study (NTR1509) were analyzed. Fourteen CYP2D6*2 carriers without the enhancer were reclassified. The relationship of CYP2D6 phenotypes and drug levels was studied. RESULTS: After correction for the absence of the enhancer, the correlation between CYP2D6 phenotypes and endoxifen did not improve (R(2): 0...
July 26, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28745388/suicidal-ideation-and-self-injurious-behavior-in-adolescents-with-eating-disorders
#13
Olalla Varela-Besteiro, Eduardo Serrano-Troncoso, Virginia Rodríguez-Vicente, Marta Curet-Santisteban, Gemma Conangla-Roselló, Raquel Cecilia-Costa, Marta Carulla-Roig, Josep L Matalí-Costa, Montserrat Dolz-Abadia
INTRODUCTION: The presence of suicidal thoughts and self-injurious behaviors in patients with eating disorders (ED) is well-known; however, this association is currently not defined empirically. The aim of the study is to determine the prevalence of suicidal ideation and self-harm in adolescents with eating disorders. A second objective is to study the association between self-injurious behavior and suicidal ideation, severity of eating disorder symptoms and symptoms of depression and anxiety, motivation to change and perfectionism...
July 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28745257/-deciding-on-surgery-for-acute-subdural-haematoma-does-a-neurosurgeon-rather-fill-nursing-homes-or-cemeteries
#14
P van Eijsden
Acute subdural haematoma is a life-threatening condition that can sometimes be mitigated by decompressive craniotomy. However, it can also increase misery when patients survive but are left with severe disabilities. A recent publication shows that neurosurgeons in Belgium and the Netherlands vary considerably in their opinion regarding if, and when, to perform this surgery. This may be due to the fact that this type of intervention asks the question whether the life saved is more favourable than the death averted...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28744801/a-retrospective-comparison-between-delayed-and-early-hip-fracture-surgery-in-patients-taking-clopidogrel-same-total-bleeding-but-different-timing-of-blood-transfusion
#15
Claire Pailleret, Zakaria Ait Hamou, Nadia Rosencher, Charles-Marc Samama, Violaine Eyraud, François Chilot, Christophe Baillard
PURPOSE: Managing hip fracture surgery in patients taking clopidogrel is challenging. The optimal timing for surgery remains unclear. Early surgery in such patients potentially increases peri-operative bleeding, whereas delayed surgery has been shown to be associated with worse postoperative outcomes. The aim of this study was to investigate whether a delay to surgery affects total blood loss, bleeding kinetics, blood transfusion requirements, or post-operative outcomes. METHODS: A retrospective monocentric study including all hip fracture patients treated with clopidogrel between 2011 and 2016 (39 patients) was carried out...
July 25, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28744725/impact-of-major-different-variants-of-papillary-thyroid-microcarcinoma-on-the-clinicopathological-characteristics-the-study-of-1041-cases
#16
Jingtai Zhi, Jingzhu Zhao, Ming Gao, Yi Pan, Jianghua Wu, Yigong Li, Dapeng Li, Yang Yu, Xiangqian Zheng
BACKGROUND: The incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results in differences in biological behavior. The aim of this study was to classify PTMCs according to the morphological features and explore the relationship with clinicopathological characteristics. Additionally, we sought to evaluate whether different variants of PTMC can be an independent predictor for lymph mode metastasis when considering other risk factors...
July 25, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28744675/potentially-inappropriate-medication-at-hospital-admission-in-patients-with-palliative-care-needs
#17
Daniel Sevilla-Sánchez, Núria Molist-Brunet, Jordi Amblàs-Novellas, Joan Espaulella-Panicot, Carles Codina-Jané
Background Potentially inappropriate medications (PIMs) are common in older patients with polypharmacy, and are related to negative clinical results. Little information is available on the characteristics and consequences of PIMs in patients with advanced chronic conditions and palliative care needs. Objective To evaluate, for this population: (i) the prevalence of PIMs; (ii) the possible risk factors associated with its onset; and (iii) the related clinical consequences. Setting Acute-hospital care Geriatric Unit (AGU) in County of Osona, Spain...
July 25, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28744666/lessons-for-patient-education-around-long-acting-injectable-prep-findings-from-a-mixed-method-study-of-phase-ii-trial-participants
#18
Kathrine Meyers, Kristina Rodriguez, Atrina L Brill, Yumeng Wu, Melissa La Mar, Debora Dunbar, Beryl Koblin, David Margolis, Magdalena E Sobieszczyk, Hong Van Tieu, Ian Frank, Martin Markowitz, Sarit A Golub
This study aimed to identify patients' physical and psychosocial experiences of an investigational long-acting injectable PrEP product to aid in the development of patient and provider education materials. Twenty-eight participants of a Phase 2 safety, tolerability, and acceptability study of long-acting integrase inhibitor cabotegravir (CAB-LA) were interviewed on their physical and psychosocial experiences of the injections. Five themes emerged through a framework analysis on these interview transcripts: (1) injection-related pain is highly variable across individuals; (2) pain is more impactful after the injections than during; (3) patient anxiety is critical, but does not determine the experience of injections and decreases over time; (4) intimacy and awkwardness of gluteal injections impacts patients' experiences; (5) patient education and care strategies can mitigate the above factors...
July 25, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28743424/blood-eosinophil-to-basophil-ratio-in-patients-with-sinonasal-polyps-does-it-have-a-clinical-role
#19
Giuseppe Brescia, Umberto Barion, Claudia Zanotti, Francesco Cinetto, Luciano Giacomelli, Alessandro Martini, Gino Marioni
BACKGROUND: In a recent preliminary study, eosinophil and basophil counts were calculated in chronic rhinosinusitis with nasal polyps (CRSwNP) using conventional histologic and immunohistochemical methods. The tissue eosinophil-to-basophil ratio differed in the CRSwNP endotypes considered. OBJECTIVE: To compare the blood eosinophil-to-basophil ratio (bEBR) in a large series of patients with CRSwNP with that in a control group of consecutive rhinological patients with no evidence of nasal, paranasal, or systemic inflammatory disorders...
July 22, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28743306/detection-of-22-common-leukemic-fusion-genes-using-a-single-step-multiplex-qrt-pcr-based-assay
#20
Xiaodong Lyu, Xianwei Wang, Lina Zhang, Zhenzhu Chen, Yu Zhao, Jieying Hu, Ruihua Fan, Yongping Song
BACKGROUND: Fusion genes generated from chromosomal translocation play an important role in hematological malignancies. Detection of fusion genes currently employ use of either conventional RT-PCR methods or fluorescent in situ hybridization (FISH), where both methods involve tedious methodologies and require prior characterization of chromosomal translocation events as determined by cytogenetic analysis. In this study, we describe a real-time quantitative reverse transcription PCR (qRT-PCR)-based multi-fusion gene screening method with the capacity to detect 22 fusion genes commonly found in leukemia...
July 25, 2017: Diagnostic Pathology
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