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https://www.readbyqxmd.com/read/28551941/-the-placebo-effect-neurobiological-aspects
#1
REVIEW
Asael Lubotzky, Adi Aran
Any medical treatment, whether it be medication, behavioral therapy or medical procedure, can affect the patient in a very complex way. Each of these forms of medical treatment have both psychobiological and physiological effects on the patient, with interactions between those levels. When considering the specific efficacy of a new treatment, there is therefore a need to neutralize the psychobiological effect by comparing the effect of the treatment to the effect of a placebo - a treatment involving similar characteristics which does not produce that physiological effect...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551859/cognitive-workload-reduction-in-hospital-information-systems-decision-support-for-order-set-optimization
#2
Daniel Gartner, Yiye Zhang, Rema Padman
Order sets are a critical component in hospital information systems that are expected to substantially reduce physicians' physical and cognitive workload and improve patient safety. Order sets represent time interval-clustered order items, such as medications prescribed at hospital admission, that are administered to patients during their hospital stay. In this paper, we develop a mathematical programming model and an exact and a heuristic solution procedure with the objective of minimizing physicians' cognitive workload associated with prescribing order sets...
May 27, 2017: Health Care Management Science
https://www.readbyqxmd.com/read/28551673/tissue-factor-expression-does-not-predict-mortality-in-breast-cancer-patients
#3
Simon F Stämpfli, Alexander Akhmedov, Silke Hausladen, Zsuzsanna Varga, Konstantin J Dedes, Jens Hellermann, Thomas F Lüscher, Glen Kristiansen, Felix C Tanner, Alexander Breitenstein
BACKGROUND: Tissue factor (TF), the trigger of coagulation, not only initiates thrombus formation, but also elicits tumor growth and invasion in breast cancer. However, the characterization of TF expression in breast cancer tissue and its prognostic value remain unclear. MATERIALS AND METHODS: Three hundred and three primary breast cancer specimens from the local tumor tissue database were immunostained for TF expression and evaluated semiquantitatively. Tumor characteristics (size, grade, nodal status, and ER expression) as well as patient's survival were assessed...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551664/antibiotic-use-does-not-appear-to-influence-response-to-nivolumab
#4
Coureche Kaderbhai, Corentin Richard, Jean David Fumet, Anne Aarnink, Pascal Foucher, Bruno Coudert, Laure Favier, Aurélie Lagrange, Emeric Limagne, Romain Boidot, Francois Ghiringhelli
BACKGROUND: Microbiota is known to influence response to anticancer immunotherapy. We examined whether antibiotic usage could impact nivolumab efficacy in patients treated for non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Seventy-four patients with NSCLC were included in this retrospective study. They received nivolumab between 2015 and 2016 (3 mg/kg i.v. q2w). The association between RECIST response and antibiotic usage was determined using Chi-square and Cox proportional hazard model...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551659/chronic-periodontitis-does-not-impact-serum-levels-of-prostate-specific-antigen
#5
Stephan Kruck, Jörg Hennenlotter, Bastian Amend, Maya Geiger, Elitsa Filipova, Tim Neumann, Viktoria Stühler, Tina Schubert, Tilman Todenhöfer, Steffen Rausch, Fabian Huettig, Arnulf Stenzl, Jens Bedke
BACKGROUND/AIM: Chronic periodontitis (CP) has already been associated with altered PSA values in men undergoing biopsy. This study addressed the impact of CP treatment on PSA screening. PATIENTS AND METHODS: Fifty-two asymptomatic men presenting for CP treatment were prospectively enrolled. Total (t)PSA, free (f)PSA and %PSA were determined (n=47) before and after therapy. Pre- and post-therapy values were correlated pairwise regarding patients and dental characteristics...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551653/clinical-relevance-of-serum-her2-and-circulating-tumor-cell-detection-in-metastatic-breast-cancer-patients
#6
Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter Andreas Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
BACKGROUND/AIM: Presence of circulating tumor cells (CTCs) is associated with impaired survival in metastatic breast cancer (MBC). This study was designed to evaluate whether assessment of serum HER2 (sHER2) levels provide additional prognostic information in MBC. MATERIALS AND METHODS: Two hundred and fifty-three MBC patients were enrolled in this multicentre trial. CTCs were detected before the start of first- or later-line treatment using the CellSearch system...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551598/novel-variant-of-common-variable-immunodeficiency
#7
Eileen Conaway
A 57-year-old woman with frequent respiratory infections was initially diagnosed with IgG subclass deficiency based on low levels of IgG subclasses 2 and 3. Three years later, she progressed to having IgA deficiency as well. With a normal total IgG level, she does not meet criteria for common variable immunodeficiency (CVID). This may represent a variant of CVID. This also highlights the importance of immunoglobulin subclass estimation in patients where immunodeficiency is suspected clinically. She is being treated with rotational antibiotics the first 10 days of every month, monthly intravenous immunoglobulin (IVIG) infusion and osteopathic manipulation one to two times per month...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28551197/-vitamin-c-sodium-bicarbonate-versus-sodium-bicarbonate-alone-in-preventing-contrast-induced%C3%A2-nephropathy
#8
L Laroussi, M Triki, Z Ibn Elhaj, A Ben Halima, M Boukhris, W Ben Amara, H Keskes, S Kraiem, D Lahidheb, S Marrakchi, I Kammoun, F Addad, S Kachboura
INTRODUCTION: Contrast-induced nephropathy (CIN) is a common and severe complication in interventional cardiology. OBJECTIVE: The aim of our study was to compare the incidence of contrast-induced nephropathy in two accelerated hydration protocols: the first one by the serum bicarbonate and the second combining the serum bicarbonate and oral vitamin C. METHODS: This is a multicenter prospective, randomized study conducted between October 2012 and May 2013, including 160 patients...
May 24, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28550988/safety-and-outcomes-of-aspirin-desensitization-for-aspirin-exacerbated-respiratory-disease-a-single-center-study
#9
Jeremy Waldram, Kristen Walters, Ronald Simon, Katherine Woessner, Jill Waalen, Andrew White
BACKGROUND: Aspirin desensitization is an effective treatment option for aspirin-exacerbated respiratory disease (AERD). Aspirin desensitization protocol modifications have improved the safety and efficiency of this procedure, yet some providers remain reluctant to perform it. OBJECTIVE: The primary objective of this study was to evaluate the safety and outcomes of outpatient aspirin desensitization procedures. A secondary objective was to assess for clinical characteristics that might predict reaction severity during aspirin desensitization...
May 24, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28550926/restrictions-on-surgical-resident-shift-length-does-not-impact-type-of-medical-errors
#10
Jamie E Anderson, Laura F Goodman, Guy W Jensen, Edgardo S Salcedo, Joseph M Galante
BACKGROUND: In 2011, resident duty hours were restricted in an attempt to improve patient safety and resident education. With the goal of reducing fatigue, shorter shift length leads to more patient handoffs, raising concerns about adverse effects on patient safety. This study seeks to determine whether differences in duty-hour restrictions influence types of errors made by residents. MATERIALS AND METHODS: This is a nested retrospective cohort study at a surgery department in an academic medical center...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550912/does-metabolic-alkalosis-influence-cerebral-oxygenation-in-infantile-hypertrophic-pyloric-stenosis
#11
Matthias Nissen, Grigore Cernaianu, Rene Thränhardt, Mohammad R Vahdad, Karin Barenberg, Ralf-Bodo Tröbs
BACKGROUND: This pilot study focuses on regional tissue oxygenation (rSO2) in patients with infantile hypertrophic pyloric stenosis in a perioperative setting. To investigate the influence of enhanced metabolic alkalosis (MA) on cerebral (c-rSO2) and renal (r-rSO2) tissue oxygenation, two-site near-infrared spectroscopy (NIRS) technology was applied. MATERIALS AND METHODS: Perioperative c-rSO2, r-rSO2, capillary blood gases, and electrolytes from 12 infants were retrospectively compared before and after correction of MA at admission (T1), before surgery (T2), and after surgery (T3)...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28550447/trends-in-surgical-research-in-head-and-neck-cancer
#12
REVIEW
Genrich Tolstonog, Christian Simon
The task of surgical research is to improve the efficacy of available surgical therapeutic modalities, develop new ones, and balance this well with favorable functional outcome. Therefore, surgical research is composed of a translational and a clinical component. In translational surgical research, animal models are used to better understand the biology of head and neck cancers, but even more importantly, the biology of changes to the disease and the microenvironment created by surgical interventions. Animal models additionally allow for the development of image-guided surgery systems, novel strategies of intraoperative adjuvant treatment, and patient "avatars" to test innovative anticancer drug combinations...
June 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28550394/laparoscopic-paraesophageal-hernia-repair-utilization-rates-of-mesh-in-the-usa-and-short-term-outcome-analysis
#13
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Many studies have shown that the utilization of mesh for paraesophageal hernia repair (PEHR) does not prevent recurrence. The aims of this study were (a) to assess the utilization of mesh for PEHR in the USA and (b) to compare the perioperative outcomes between PEHR with and without mesh. METHODS: A retrospective population-based analysis was performed using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database...
May 26, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28550248/cd44-splice-variants-as-potential-players-in%C3%A2-alzheimer-s-disease-pathology
#14
Elhanan Pinner, Yaron Gruper, Micha Ben Zimra, Don Kristt, Moshe Laudon, David Naor, Nava Zisapel
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive deficits, deposition of amyloid-β (Aβ) plaques, intracellular neurofibrillary tangles, and neuronal cell death. Neuroinflammation is commonly believed to participate in AD pathogenesis. CD44 is an inflammation-related gene encoding a widely-distributed family of alternatively spliced cell surface glycoproteins that have been implicated in inflammation, metastases, and inflammation-linked neuronal injuries. Here we investigated the expression patterns of CD44S (which does not contain any alternative exon) and CD44 splice variants in postmortem hippocampal samples from AD patients and matched non-AD controls...
May 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28550146/does-painless-rectal-bleeding-equate-to-a-colonic-polyp
#15
Alison Morag Campbell, Ian Sugarman
BACKGROUND: It is often stated that if a patient presents with 'painless rectal bleeding' then a rectal polyp is the probable diagnosis. The aim of this study is to review our experience of children undergoing endoscopy to assess if the above statement is correct. METHODS: The senior author keeps a prospective database of every child undergoing flexible sigmoidoscopy or colonoscopy. As part of this database, the symptoms and signs that the patient presents with, specifically abdominal pain, diarrhoea, mucous per rectum and rectal bleeding, are recorded...
May 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28549963/the-role-of-the-profundoplasty-in-the-modern-management-of-patient-with-peripheral-vascular-disease
#16
Maurizio Taurino, Francesca Persiani, Roberta Ficarelli, Federico Filippi, Raffaele Dito, Luigi Rizzo
OBJECTIVE: The occlusion of superficial femoris artery (SFA), is a common feature in peripheral vascular disease, so the profunda femoris artery (PFA) is a crucial collateral pathway for the perfusion of the lower limb. The purpose of this study is to discuss the safety, clinical and hemodynamic efficacy of profundoplasty on the basis of limb salvage, patency and freedom from reintervention rates. Furthermore this study aims to identify the risk factors linked to the failure of the procedure...
May 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28549929/pragmatic-trials-and-real-world-evidence-an-introduction-to-the-series
#17
Mira Zuidgeest, Iris Goetz, Rolf Groenwold, Elaine Irving, Ghislaine van Thiel, Diederick E Grobbee
This is the introductory paper in a series of 8 papers (see box). In this series we integrate the theoretical design options with the practice of conducting pragmatic trials. For most new market-approved treatments the clinical evidence is insufficient to fully guide physicians and policy makers in choosing the optimal treatment for their patients. Pragmatic trials can fill this gap, by providing evidence on the relative effectiveness of a treatment strategy in routine clinical practice, already in an early phase of development, while maintaining the strength of randomized controlled trials...
May 23, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28549772/codon-optimized-rpgr-improves-stability-and-efficacy-of-aav8-gene-therapy-in-two-mouse-models-of-x-linked-retinitis-pigmentosa
#18
M Dominik Fischer, Michelle E McClements, Cristina Martinez-Fernandez de la Camara, Julia-Sophia Bellingrath, Daniyar Dauletbekov, Simon C Ramsden, Doron G Hickey, Alun R Barnard, Robert E MacLaren
X-linked retinitis pigmentosa (XLRP) is generally a severe form of retinitis pigmentosa, a neurodegenerative, blinding disorder of the retina. 70% of XLRP cases are due to mutations in the retina-specific isoform of the gene encoding retinitis pigmentosa GTPase regulator (RPGR(ORF15)). Despite successful RPGR(ORF15) gene replacement with adeno-associated viral (AAV) vectors being established in a number of animal models of XLRP, progression to human trials has not yet been possible. The inherent sequence instability in the purine-rich region of RPGR(ORF15) (which contains highly repetitive nucleotide sequences) leads to unpredictable recombination errors during viral vector cloning...
May 24, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28549749/shared-decision-making-in-iran-current-and-future-trends
#19
Samira Abbasgholizadeh Rahimi, Mahasti Alizadeh, France Légaré
This paper describes the current situation of shared decision making (SDM) in the Iranian healthcare system, discusses barriers to implementation and gives future directions. What about policy regarding SDM? Although the Ministry of Health and Medical Education has enacted some legislation on informed consent and patients' rights, there is no policy specifically regarding SDM in Iran. What about decision support tools for patients? Although some Iranian researchers and clinicians have highlighted patients' desire to be informed and involved in decisions related to their health, there is no program to develop or evaluate decision support tools such as patient decision aids in Iran...
May 23, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28549744/survival-after-resection-of-perihilar-cholangiocarcinoma-in%C3%A2-patients-with-lymph-node-metastases
#20
Stefan Buettner, Jeroen L A van Vugt, Marcia P Gaspersz, Robert J S Coelen, Eva Roos, Tim A Labeur, Georgios A Margonis, Cecilia G Ethun, Shishir K Maithel, George Poultsides, Thuy Tran, Kamran Idrees, Chelsea A Isom, Ryan C Fields, Bradley A Krasnick, Sharon M Weber, Ahmed Salem, Robert C G Martin, Charles R Scoggins, Perry Shen, Harveshp D Mogal, Carl Schmidt, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Jan N M IJzermans, Thomas M van Gulik, Timothy M Pawlik, Bas Groot Koerkamp
BACKGROUND: The aim of this study was to compare patients with PHC with lymph node metastases (LN+) who underwent a resection with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy. METHODS: Consecutive LN+ patients who underwent a resection for PHC in 12 centers were compared with patients who did not undergo resection because of locally advanced disease at exploratory laparotomy in 2 centers. RESULTS: In the resected cohort of 119 patients, the median overall survival (OS) was 19 months and the estimated 1-, 3- and 5-year OS was 69%, 27% and 13%, respectively...
May 23, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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