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Imipramine

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https://www.readbyqxmd.com/read/29759225/ceo-2-cb-nanocomposite-as-a-novel-saldi-substrate-for-enhancing-the-detection-sensitivity-of-pharmaceutical-drug-molecules-in-beverage-samples
#1
Entesar Al-Hetlani, Mohamed O Amin, Metwally Madkour, Ahmed Abdel Nazeer
SALDI-MS analysis of pharmaceutical drug molecules (amitriptyline, imipramine and promazine) using carbon-based substrates, namely, activated charcoal (AC), carbon nanotubes (CNTs), carbon black (CB), graphene (rGO), graphene oxide (GO) and graphite, was explored and compared with the conventional organic matrix of MALDI. CB exhibited superior performance with respect to the other substrates in terms of detection sensitivity. Despite the effectiveness of CB to detect all drug molecules, it demonstrated a number of background signals, which may be an issue for the analysis of other molecules in the future...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29759138/impact-of-imipramine-on-proteome-of-rat-primary-glial-cells
#2
Sylwia Kedracka-Krok, Bianka Swiderska, Anna M Bielecka-Wajdman, Gabriela Prus, Bozena Skupien-Rabian, Urszula Jankowska, Ewa Obuchowicz
Microglia and astrocytes, two types of glial cells are known to be important targets for antidepressant drugs. Here we used a comprehensive proteomic analysis to examine the effect of imipramine on rat primary mixed glial culture. The two-dimensional differential gel electrophoresis method allowed us to identify 62 proteins that were altered by imipramine. Functional analysis revealed that imipramine influenced the level of proteins involved in oxidative stress; in particular, it elevated the level of glutathione transferases...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29743870/absence-of-wdr13-gene-predisposes-mice-to-mild-social-isolation-chronic-stress-leading-to-depression-like-phenotype-associated-with-differential-expression-of-synaptic-proteins
#3
Shiladitya Mitra, Ghantasala S Sameer Kumar, B Jyothi Lakshmi, Suman Thakur, Satish Kumar
We earlier reported that the male mice lacking the Wdr13 gene ( Wdr13 -/0 ) showed mild anxiety, better memory retention, and up-regulation of synaptic proteins in the hippocampus. With increasing evidences from parallel studies in our laboratory about the possible role of Wdr13 in stress response, we investigated its role in brain. We observed that Wdr13 transcript gets up-regulated in the hippocampus of the wild-type mice exposed to stress. To further dissect its function, we analyzed the behavioral and molecular phenotypes of Wdr13 -/0 mice when subjected to mild chronic psychological stress, namely; mild (attenuated) social isolation...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29743852/n1-benzenesulfonyl-2-pyrazoline-hybrids-in-neurological-disorders-syntheses-biological-screening-and-computational-studies
#4
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t ) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, applying conventional and green chemistry approaches. Among the two, microwave assisted organic synthesis (MAOS) emerged as a better synthetic tool in terms of faster reaction rate and high yield. Various physicochemical and spectral studies were conducted to characterize the synthesized derivatives including- IR, Mass, 1 H-NMR, 13 C-NMR and elemental analysis...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29742109/effect-of-single-dose-imipramine-on-chronic-low-back-and-experimental-pain-a-randomized-controlled-trial
#5
Jürg Schliessbach, Andreas Siegenthaler, Lukas Bütikofer, Andreas Limacher, Peter Juni, Pascal H Vuilleumier, Ulrike Stamer, Lars Arendt-Nielsen, Michele Curatolo
Antidepressants are frequently prescribed as co-analgesics in chronic pain. While their efficacy is well documented for neuropathic pain, the evidence is less clear in musculoskeletal pain conditions. The present study therefore evaluated the effect of the tricyclic antidepressant imipramine on chronic low-back pain in a randomized, double-blinded placebo-controlled design. To explore the mechanisms of action and the influence of drug metabolism, multimodal quantitative sensory tests (QST) and genotyping for cytochrome P450 2D6 (CYP2D6) were additionally performed...
2018: PloS One
https://www.readbyqxmd.com/read/29741917/a-systematic-review-of-pharmacologic-treatments-for-school-refusal-behavior
#6
Amalia Londono Tobon, Margot O Reed, Jerome H Taylor, Michael H Bloch
OBJECTIVE: School refusal is an important pediatric problem with significant negative short- and long-term outcomes. Specific psychosocial treatments appear effective in reducing school refusal, but many children do not respond to these treatments. Although systematic reviews have examined the efficacy of psychological interventions for school refusal, no systematic reviews on pharmacological interventions exist. METHODS: We conducted a comprehensive literature search of MEDLINE, PsycINFO, Scopus, and Embase for randomized controlled trials (RCTs) or quasi-experimental pharmacologic trials in children and adolescents with school refusal reported in English or Spanish until July 1, 2017...
May 9, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29741894/structures-of-ebolavirus-glycoprotein-complexes-with-tricyclic-antidepressant-and-antipsychotic-drugs
#7
Yuguang Zhao, Jingshan Ren, Elizabeth Evelyn Fry, Julia Xiao, Alain R Townsend, David I Stuart
A large number of Food and Drug Administration (FDA) approved drugs have been found to inhibit cell entry of Ebola virus (EBOV). However, since these drugs have various primary pharmacological targets their mechanisms of action against EBOV remain largely unknown. We have previously shown that six FDA approved drugs inhibit EBOV infection by interacting with and destabilizing the viral glycoprotein (GP). Here we show that the antidepressants imipramine and clomipramine, and antipsychotic drug thioridazine also directly interact with EBOV GP, and determine the mode of interaction by crystallographic analysis of the complexes...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29720938/isolation-and-characterization-of-two-new-secondary-metabolites-from-quercus-incana-and-their-antidepressant-and-anxiolytic-like-potential
#8
Rizwana Sarwar, Umar Farooq, Sadia Naz, Ajmal Khan, Syed M Bukhari, Haroon Khan, Nasiara Karim, Imran Khan, Ayaz Ahmed, Ahmed Al-Harrasi
The ethyl acetate fraction of Quercus incana yielded two new compounds [ 1 and 2 ]. The characterization and structure elucidation of these compounds were carried out through various spectroscopic techniques such as mass spectrometry along with one- and two-dimensional NMR techniques. The structural formula was deduced to be 2-(4-hydroxybutan-2-yl)-5-methoxyphenol [ 1 ] and 4-hydroxy-3-(hydroxymethyl) pentanoic acid [ 2 ]. The elevated plus maze (EPM) and light-dark box (LDB) tests (classical mouse models) were performed in order to reveal the anxiolytic potential of both compounds [ 1 and 2 ]...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29713785/regulation-of-somatostatin-receptor-2-in-the-context-of-antidepressant-treatment-response-in-chronic-mild-stress-in-rat
#9
Agata Faron-Górecka, Maciej Kuśmider, Joanna Solich, Magdalena Kolasa, Paulina Pabian, Piotr Gruca, Irena Romańska, Dariusz Żurawek, Marta Szlachta, Mariusz Papp, Lucyna Antkiewicz-Michaluk, Marta Dziedzicka-Wasylewska
RATIONALE: The role of somatostatin and its receptors for the stress-related neuropsychiatric disorders has been widely raised. Recently, we have also demonstrated the involvement of somatostatin receptor type 2-sst2R and dopamine receptor type 2-D2R in stress. OBJECTIVE: In this context, we decided to find if these receptors are involved in response to antidepressant treatment in animal model of depression-chronic mild stress (CMS). METHODS: Here, we report data obtained following 7-week CMS procedure...
April 30, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29712539/the-ethanolic-extract-obtained-from-campomanesia-pubescens-d-c-o-berg-fruits-exerts-anxiolytic-and-antidepressant-effects-on-chronic-mild-stress-model-and-on-anxiety-models-in-wistar-rats-behavioral-evidences
#10
Gustavo Roberto Villas Boas, Ana Paula Stefanello da Silveira, Brunna Charlla Feitosa Farinelli, Claudia Andréa Lima Cardoso, Emely Arce, Silvia Aparecida Oesterreich
OBJECTIVES: Campomanesia pubescens (DC) O.BERG (Myrtaceae) fruits contain high levels of flavonoids and are widely consumed by the South American population. In the central nervous system (CNS), some flavonoids act as modulators of GABA-A receptors and monoamine oxidase inhibitors, resulting in anxiolytic antidepressants effects, respectively. The objective of the present study was to evaluate the anxiolytic and antidepressant effects of ethanolic extract of C. pubescens fruits (EEFCP) in rats...
May 1, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29704625/tricyclic-antidepressants-inhibit-hippocampal-%C3%AE-7-and-%C3%AE-9%C3%AE-10-nicotinic-acetylcholine-receptors-by-different-mechanisms
#11
Hugo R Arias, Elizabeth Vázquez-Gómez, Andy Hernández-Abrego, Sofía Gallino, Dominik Feuerbach, Marcelo O Ortells, Ana Belén Elgoyhen, Jesús García-Colunga
The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca2+ influx and electrophysiological recordings. To determine the inhibitory mechanisms, additional functional tests and molecular docking experiments are performed. The results established that TCAs (a) inhibit Ca2+ influx in GH3-α7 cells with the following potency (IC50 in µM) rank: amitriptyline (2.7 ± 0.3) > doxepin (5...
April 25, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29697017/high-fat-diet-induces-depression-like-behaviour-in-mice-associated-with-changes-in-microbiome-neuropeptide-y-and-brain-metabolome
#12
Ahmed M Hassan, Giulia Mancano, Karl Kashofer, Esther E Fröhlich, Andrija Matak, Raphaela Mayerhofer, Florian Reichmann, Marta Olivares, Audrey M Neyrinck, Nathalie M Delzenne, Sandrine P Claus, Peter Holzer
OBJECTIVES: The biological mechanisms linking diet-related obesity and depression remain unclear. Therefore, we examined the impact of high-fat diet (HFD) on murine behaviour, intestinal microbiome, brain metabolome, neuropeptide Y (NPY) expression, and dipeptidyl peptidase-4 (DPP-4) activity. METHODS: Male C57Bl/6J mice were fed an HFD (60 kJ% from fat) or control diet (12 kJ% from fat) for 8 weeks, followed by behavioural phenotyping. Caecal microbiome was analysed by 16S rDNA sequencing, brain metabolome by 1 H nuclear magnetic resonance, NPY expression by PCR and immunoassay, and dipeptidyl peptidase-4 (DPP-4) activity by enzymatic assay...
April 26, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29689697/prostate-cancer-and-antidepressants-a-nationwide-population-based-nested-case-control-study
#13
Wei-Yu Lin, Vincent Chin-Hung Chen, Wei-Che Chiu, Samantha J Yim, Peter T Ho, Roger S McIntyre, Mong-Liang Lu, Shui-I Wu
BACKGROUND: We aimed to evaluate the association between antidepressant and prostate cancer by comparing exposures to antidepressants between those with and without prostate cancer. METHODS: A nationwide insurance claims database was used to identify our case subjects. Age- and gender-matched controls were selected at a 1:5 ratio. Conditional logistic regression model was used. RESULTS: 11,515 patients with prostate cancer were identified and matched with 55,373 controls...
February 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29688573/antidepressants-for-the-treatment-of-people-with-co-occurring-depression-and-alcohol-dependence
#14
REVIEW
Roberta Agabio, Emanuela Trogu, Pier Paolo Pani
BACKGROUND: Alcohol dependence is a major public health problem characterized by recidivism, and medical and psychosocial complications. The co-occurrence of major depression in people entering treatment for alcohol dependence is common, and represents a risk factor for morbidity and mortality, which negatively influences treatment outcomes. OBJECTIVES: To assess the benefits and risks of antidepressants for the treatment of people with co-occurring depression and alcohol dependence...
April 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29669730/drug-induced-alterations-of-mitochondrial-dna-homeostasis-in-steatotic-and-non-steatotic-heparg-cells
#15
Dounia Le Guillou, Simon Bucher, Karima Begriche, Delphine Hoet, Anne Lombes, Gilles Labbe, Bernard Fromenty
Although mitochondriotoxicity plays a major role in drug-induced hepatotoxicity, alteration of mitochondrial DNA (mtDNA) homeostasis has been described only with a few drugs. Because it requires long drug exposure, this mechanism of toxicity cannot be detected with investigations performed in isolated liver mitochondria or cultured cells exposed to drugs for several hours, or a few days. Thus, a first aim of this study was to determine whether a 2-week treatment with 9 hepatotoxic drugs could affect mtDNA homeostasis in HepaRG cells...
April 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29642692/noncardiac-chest-pain-a-2018-update
#16
Marilena Durazzo, Giuseppe Gargiulo, Rinaldo Pellicano
Noncardiac chest pain (NCCP) is defined as recurring, angina-like, chest pain of noncardiac origin. Studies have estimated that gastroesophageal reflux disease (GERD) is the most common contributing factor for NCCP. In patients with non-GERD related NCCP, esophageal motility disorders, and functional chest pain (FCP) of presumed esophageal origin are the main underlying mechanisms for symptoms. Epidemiologic studies show a high prevalence of panic disorder, anxiety and major depression in NCCP patients. The diagnostic esophageal workup starts only after that cardiac and pulmonary diseases have been ruled out...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29626770/estimating-environmental-fate-of-tricyclic-antidepressants-in-wastewater-treatment-plant
#17
Jong-Won Choi, Yufeng Zhao, John Kwame Bediako, Chul-Woong Cho, Yeoung-Sang Yun
TCAs are known to be toxicants and endocrine disrupting agents. Generally, after being used, TCAs are passed through wastewater treatment plants (WWTPs) to be treated. However, still trace amounts (ng/L to μg/L) of TCAs have been founded even in the treated water. Therefore, the aim of this study is to elucidate the environmental behaviors of TCAs in the sewage water from WWTPs (Jeonju, Korea). For the experiments, seven TCAs (amitriptyline, imipramine, clomipramine, desipramine, protriptyline, nortriptyline, and doxepin) were selected...
April 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29615471/pharmacological-characterizations-of-h05-a-novel-potent-serotonin-and-noradrenaline-reuptake-inhibitor-with-moderate-5-ht2a-antagonist-activity-for-anti-depression
#18
Xiangqing Xu, Yaqin Wei, Qiang Guo, Song Zhao, Zhiqiang Liu, Ting Xiao, Yani Liu, Yinli Qiu, Yuanyuan Hou, Guisen Zhang, Kewei Wang
Multi-target antidepressants selectively inhibiting monoaminergic transporters and 5-HT2A receptors have demonstrated higher efficacy and fewer side effects than selective serotonin reuptake inhibitors (SSRIs). In the present study, we synthesized a series of novel 3-(benzo[d] [1, 3] dioxol-4-yloxy)-3-arylpropyl amine derivatives, among which H05 was identified as a lead compound with potent inhibition effects on both serotonin (Ki=4.81 nM) and norepinephrine (Ki=6.72 nM) transporters and moderate 5-HT2A antagonist activity (IC50=60...
April 3, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29602316/effect-of-cytochrome-p450-cyp-2d6-genetic-polymorphism-on-the-inhibitory-action-of-antidepressants-on-cyp2d6-mediated-dopamine-formation-from-p-tyramine
#19
Toshiro Niwa, Mayumi Yanai, Maya Matsumoto, Marina Shizuku
PURPOSE: The inhibitory effects of antidepressants, such as imipramine, desipramine, and fluvoxamine, on dopamine formation from p-tyramine catalyzed by cytochrome P450 (CYP) 2D6.2 (Arg296Cys, Ser486Thr) and CYP2D6.10 (Pro34Ser, Ser486Thr), were compared with those on dopamine formation catalyzed by CYP2D6.1 (wild type), to investigate the effect of a CYP2D6 polymorphism on neuroactive amine metabolism in the brain. METHODS: Inhibition constants (Ki) of the antidepressants toward dopamine formation catalyzed by CYP2D6...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29582445/development-of-new-extraction-method-based-on-liquid-liquid-liquid-extraction-followed-by-dispersive-liquid-liquid-microextraction-for-extraction-of-three-tricyclic-antidepressants-in-plasma-samples
#20
Mir Ali Farajzadeh, Maryam Abbaspour
In the present study, a new extraction method based on a three-phase system liquid-liquid-liquid extraction followed by dispersive liquid-liquid microextraction has been developed and validated for the extraction and preconcentration of three commonly prescribed tricyclic antidepressant drugs including amitriptyline, imipramine, and clomipramine in human plasma prior to their analysis by gas chromatography-flame ionization detection. Three phases are an aqueous phase (plasma), acetonitrile, and n-hexane. The extraction mechanism is based on the different affinities of components of the biological sample (lipids, fatty acids, pharmaceuticals, inorganic ions, etc...
March 27, 2018: Biomedical Chromatography: BMC
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