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https://www.readbyqxmd.com/read/28738203/early-detection-monitoring-for-aquatic-non-indigenous-species-optimizing-surveillance-incorporating-advanced-technologies-and%C3%A2-identifying-research-needs
#1
REVIEW
Anett S Trebitz, Joel C Hoffman, John A Darling, Erik M Pilgrim, John R Kelly, Emily A Brown, W Lindsay Chadderton, Scott P Egan, Erin K Grey, Syed A Hashsham, Katy E Klymus, Andrew R Mahon, Jeffrey L Ram, Martin T Schultz, Carol A Stepien, James C Schardt
Following decades of ecologic and economic impacts from a growing list of nonindigenous and invasive species, government and management entities are committing to systematic early- detection monitoring (EDM). This has reinvigorated investment in the science underpinning such monitoring, as well as the need to convey that science in practical terms to those tasked with EDM implementation. Using the context of nonindigenous species in the North American Great Lakes, this article summarizes the current scientific tools and knowledge - including limitations, research needs, and likely future developments - relevant to various aspects of planning and conducting comprehensive EDM...
July 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28735035/the-lamin-code
#2
Nadir M Maraldi
Unicellular eukaryotes and metazoa present a nuclear envelope (NE) and metazoa express in it one or more lamins that give rise to the nuclear lamina. The expression of different types of lamins is related to the complexity of the organism and the expression of type-A lamins is related to the initial steps of tissue-specific cell differentiation. Several posttranslational modifications characterize the expression of lamin A in the course of cell differentiation, and the alteration of this expression pattern leads to impressive phenotypic diseases that are collectively referred to as laminopathies...
July 19, 2017: Bio Systems
https://www.readbyqxmd.com/read/28726548/wnt-yap-interactions-during-neural-tissue-patterning-of-human-induced-pluripotent-stem-cells
#3
Julie Bejoy, Liqing Song, Yi Zhou, Yan Li
Human induced pluripotent stem cells (hiPSCs) have special ability to self-assemble into neural spheroids or mini-brain like structures. During the self-assembly process, Wnt signaling plays an important role in regional patterning and establishing positional identity of hiPSC-derived neural progenitors. Recently, the role of Wnt signaling in regulating Yes-associated protein (YAP) expression (nuclear or cytoplasmic), the pivotal regulator during organ growth and tissue generation, has attracted increasing interests...
July 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28724671/accountable-care-communities
#4
Marcus Plescia, Michael Dulin
Accountable care communities are a new health model that involves multiple stakeholders working together to improve the health and well-being of their communities by addressing social determinants of health. Stakeholders include health care delivery systems, public health organizations, and community organizations. In an accountable care community, the stakeholders commit to share responsibility, resources, and data to improve community health indicators. Accountable care communities are a promising model to both decrease medical costs and improve health outcomes by placing greater emphasis on addressing social and economic issues that ultimately define health...
July 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28724531/the-tobacco-free-village-program-helping-rural-areas-implement-and-achieve-goals-of-tobacco-control-policies-in-india
#5
Nilesh Chatterjee, Deepak Patil, Rajashree Kadam, Genevie Fernandes
India has 274 million tobacco users and a tobacco use prevalence of 38% in rural areas. Tobacco consumption causes 1 million deaths and costs the health system nearly US$23 billion annually. Tobacco control policies exist but lack proper implementation. In this article, we review the Tobacco-free Village (TfV) program conducted in Maharashtra state in India and describe its process to help villages in rural India achieve "tobacco-free" status (i.e., the sale and use of tobacco are prohibited by law). We reviewed program documents and conducted 22 qualitative interviews with program staff and village-level stakeholders...
July 19, 2017: Global Health, Science and Practice
https://www.readbyqxmd.com/read/28724129/association-of-cost-sharing-with-mental-health-care-use-involuntary-commitment-and-acute-care
#6
Bastian Ravesteijn, Eli B Schachar, Aartjan T F Beekman, Richard T J M Janssen, Patrick P T Jeurissen
Importance: A higher out-of-pocket price for mental health care may lead not only to cost savings but also to negative downstream consequences. Objective: To examine the association of higher patient cost sharing with mental health care use and downstream effects, such as involuntary commitment and acute mental health care use. Design, Setting, and Participants: This difference-in-differences study compared changes in mental health care use by adults, who experienced an increase in cost sharing, with changes in youths, who did not experience the increase and thus formed a control group...
July 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28724026/-level-of-implementation-of-the-program-for-safety-and-health-at-work-in-antioquia-colombia
#7
Ninfa Del Carmen Vega-Monsalve
This study describes the level of implementation of the Program for Safety and Health at Work in companies located in the Department of Antioquia, Colombia, and associated factors. A cross-sectional survey included 73 companies with more than 50 workers each and implementation of the program. A total of 65 interviews were held, in addition to 73 checklists and process reviews. The companies showed suboptimal compliance with the management model for workplace safety and health proposed by the International Labor Organization (ILO)...
July 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28721554/feasibility-of-a-self-help-web-based-intervention-targeting-young-cancer-patients-with-sexual-problems-and-fertility-distress
#8
Maria Wiklander, Johanna Strandquist, Claire Micaux Obol, Lars E Eriksson, Jeanette Winterling, Kenny A Rodriguez-Wallberg, Kerstin Sjögren Fugl-Meyer, Johan Ahlgren, Per Ljungman, Claudia Lampic, Lena Wettergren
PURPOSE: The purpose of the study is to evaluate the feasibility of a self-help web-based intervention to alleviate sexual problems and fertility distress in adolescents and young adults with cancer. METHODS: Twenty-three persons with cancer (19 women and 4 men, age 18-43, 1-5 years post-diagnosis of lymphoma, breast, gynecologic, central nervous system, or testicular cancer) were recruited to test a 2-month web-based program targeting sexual problems or fertility distress...
July 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28720090/-we-and-the-nurses-are-now-working-with-one-voice-how-community-leaders-and-health-committee-members-describe-their-role-in-sierra-leone-s-ebola-response
#9
Shannon A McMahon, Lara S Ho, Kerry Scott, Hannah Brown, Laura Miller, Ruwan Ratnayake, Rashid Ansumana
BACKGROUND: Across low-income settings, community volunteers and health committee members support the formal health system - both routinely and amid emergencies - by engaging in health services such as referrals and health education. During the 2014-2015 Ebola epidemic, emerging reports suggest that community engagement was instrumental in interrupting transmission. Nevertheless, literature regarding community volunteers' roles during emergencies generally, and Ebola specifically, is scarce...
July 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28716091/suppression-of-the-phytoene-synthase-gene-egcrtb-alters-carotenoid-content-and-intracellular-structure-of-euglena-gracilis
#10
Shota Kato, Mika Soshino, Shinichi Takaichi, Takahiro Ishikawa, Noriko Nagata, Masashi Asahina, Tomoko Shinomura
BACKGROUND: Photosynthetic organisms utilize carotenoids for photoprotection as well as light harvesting. Our previous study revealed that high-intensity light increases the expression of the gene for phytoene synthase (EgcrtB) in Euglena gracilis (a unicellular phytoflagellate), the encoded enzyme catalyzes the first committed step of the carotenoid biosynthesis pathway. To examine carotenoid synthesis of E. gracilis in response to light stress, we analyzed carotenoid species and content in cells grown under various light intensities...
July 17, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28714568/exposure-to-reversine-affects-the-chondrocyte-morphology-and-phenotype-in-vitro
#11
S Gasparini, F Villa, L Molfetta, E Repaci, P Castagnola, R Quarto, P Giannoni
Articular chondrocytes derived from osteoarthritic tissues (OA-HAC) show a severely reduced chondrogenic commitment. This impairment undermines their use for tissue-engineered cartilage repair, which relies on cell proliferation and growth to meet the therapeutic needs but also on efficient cell plasticity to recover the chondrogenic phenotype. Reversine (Rev), a 2,6-disubstituted purine inhibitor of spindle-assembly checkpoints, was described to convert differentiated mesenchymal cells to their undifferentiated precursors...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28711650/role-of-satb2-in-distinguishing-the-site-of-origin-in-glandular-lesions-of-the-bladder-urinary-tract
#12
Giovanna Angela Giannico, Allen M Gown, Jonathan I Epstein, Frank Revetta, Justin A Bishop
The differential diagnosis of glandular lesions of the bladder/urinary tract can be challenging due to significant morphologic and immunohistochemical overlap between primary lesions and metastasis/direct extension from adjacent organs. Special AT-rich sequence-binding protein 2 (SATB2), encoded on chromosome 2q32-33, is a recently described DNA-binding protein involved in osteoblast lineage commitment and expressed in colorectal and appendiceal neoplasms. In this study, we hypothesized that immunohistochemistry for SATB2 may be of value in distinguishing primary adenocarcinoma of the bladder/urinary tract and urothelial carcinoma with glandular differentiation from gastrointestinal and endocervical primaries...
July 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28711273/treatment-methods-following-suicidal-self-administration-of-iv-organophosphate-what-can-additional-lipid-administration-change
#13
Kenan Ahmet Turkdogan, Ali Duman, Mucahit Avcil, Ayhan Akoz, Selcuk Eren Canakcı, Burcak Kantekin
Organic phosphor compounds are highly toxic and life-threatening compounds that are widely used in agriculture, households and gardens worldwide. While oral intakes are observed frequently, toxic effects can also be seen through contract or inhalation. However, toxic cases through the parenteral route have rarely been reported. We had three main aims: first, to present a male patient who self-administered 2ml of monocrotophos intravenously to commit suicide. Our second goal was to present the current multiple treatment methods, such as fast general support, antidote treatment, lipid emulsion treatment, and plasmapheresis along with the literature...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28710355/high-resolution-imaging-of-dna-methylation-dynamics-using-a-zebrafish-reporter
#14
Ranran Zhang, Lian Liu, Yuxiao Yao, Fei Fei, Feng Wang, Qian Yang, Yonghao Gui, Xu Wang
As one of the major epigenetic modifications, DNA methylation is constantly regulated during embryonic development, cell lineage commitment, and pathological processes. To facilitate real-time observation of DNA methylation, we generated a transgenic zebrafish reporter of DNA methylation (zebraRDM) via knockin of an mCherry-fused methyl-CpG binding domain (MBD) probe driven by the bactin2 promoter. The probe colocalized with heterochromatin, and its intensity was positively correlated with 5 mC immunostaining at a subcellular resolution in early embryos...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706777/using-community-based-participatory-research-and-organizational-diagnosis-to-characterize-relationships-between-community-leaders-and-academic-researchers
#15
Karen H Wang, Natasha J Ray, David N Berg, Ann T Greene, Georgina Lucas, Kenn Harris, Amy Carroll-Scott, Barbara Tinney, Marjorie S Rosenthal
Sustaining collaborations between community-based organization leaders and academic researchers in community-engaged research (CEnR) in the service of decreasing health inequities necessitates understanding the collaborations from an inter-organizational perspective. We assessed the perspectives of community leaders and university-based researchers conducting community-engaged research in a medium-sized city with a history of community-university tension. Our research team, included experts in CEnR and organizational theory, used qualitative methods and purposeful, snowball sampling to recruit local participants and performed key informant interviews from July 2011-May 2012...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28705012/the-relationship-between-core-members-social-capital-and-perceived-and-externally-evaluated-prestige-and-cooperation-among-hiv-aids-related-civil-society-organizations-in-china
#16
Danni Wang, Xiaoru Xu, Guangliang Mei, Ying Ma, Ren Chen, Xia Qin, Zhi Hu
The purpose of this study was to investigate whether the core members' social capital was associated with individually perceived and externally evaluated prestige and cooperation among the HIV/AIDS-related civil society organizations (CSOs). To accomplish this, a cross-sectional study using multistage sampling was carried out in eight provinces of China. Data were collected from the 327 core members via questionnaires and self-evaluated performance of the respondents were evaluated and measured. The interviews were conducted with all core members and the supervisory staff of the local Centers for Disease Control and Prevention...
March 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/28700915/a-model-for-adult-organ-resizing-demonstrates-stem-cell-scaling-through-a-tunable-commitment-rate
#17
XinXin Du, Lucy Erin O'Brien, Ingmar Hans Riedel-Kruse
Many adult organs grow or shrink to accommodate different physiological demands. Often, as total cell number changes, stem cell number changes proportionally in a phenomenon called "stem cell scaling". The cellular behaviors that give rise to scaling are unknown. Here we study two complementary theoretical models of the adult Drosophila midgut, a stem cell-based organ with known resizing dynamics. First, we derive a differential equations model of midgut resizing and show that the in vivo kinetics of growth can be recapitulated if the rate of fate commitment depends on the tissue's stem cell proportion...
July 11, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28693391/leading-nurses-emotional-intelligence-and-leadership-development-effectiveness
#18
Kerri Anne Crowne, Thomas M Young, Beryl Goldman, Barbara Patterson, Anne M Krouse, Jose Proenca
Purpose The purpose of this paper is to examine the effectiveness of an emotional intelligence (EI) and leadership development education program involving 20 nurse leaders at nursing homes. Also, it investigates the relationship between EI and transformational leadership. Design/methodology/approach Three research questions are posed. Correlation analysis and t-tests were conducted to answer the questions posed. Findings The findings of this paper indicate that the EI educational development was effective, while the personal leadership development was not...
July 3, 2017: Leadership in Health Services
https://www.readbyqxmd.com/read/28686860/muscle-stem-cells-undergo-extensive-clonal-drift-during-tissue-growth-via-meox1-mediated-induction-of-g2-cell-cycle-arrest
#19
Phong Dang Nguyen, David Baruch Gurevich, Carmen Sonntag, Lucy Hersey, Sara Alaei, Hieu Tri Nim, Ashley Siegel, Thomas Edward Hall, Fernando Jaime Rossello, Sarah Elizabeth Boyd, Jose Maria Polo, Peter David Currie
Organ growth requires a careful balance between stem cell self-renewal and lineage commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that mediate this balance are unresolved in most organs, including skeletal muscle. Here we identify a long-lived stem cell pool that mediates growth of the zebrafish myotome. This population exhibits extensive clonal drift, shifting from random deployment of stem cells during development to reliance on a small number of dominant clones to fuel the vast majority of muscle growth...
July 6, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28681151/three-dimensional-spatiotemporal-modeling-of-colon-cancer-organoids-reveals-that-multimodal-control-of-stem-cell-self-renewal-is-a-critical-determinant-of-size-and-shape-in-early-stages-of-tumor-growth
#20
Huaming Yan, Anna Konstorum, John S Lowengrub
We develop a three-dimensional multispecies mathematical model to simulate the growth of colon cancer organoids containing stem, progenitor and terminally differentiated cells, as a model of early (prevascular) tumor growth. Stem cells (SCs) secrete short-range self-renewal promoters (e.g., Wnt) and their long-range inhibitors (e.g., Dkk) and proliferate slowly. Committed progenitor (CP) cells proliferate more rapidly and differentiate to produce post-mitotic terminally differentiated cells that release differentiation promoters, forming negative feedback loops on SC and CP self-renewal...
July 5, 2017: Bulletin of Mathematical Biology
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