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Status epilepticus

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https://www.readbyqxmd.com/read/29778845/predictors-of-long-term-mortality-in-status-epilepticus
#1
Somsak Tiamkao, Pawinee Saybungkla, Prapassara Sirikarn, Kittisak Sawanyawisuth
BACKGROUND: There were several studies that have reported on the long-term mortality rate of status epilepticus (SE). However, these studies were conducted mainly in Western countries using small study populations. This study aimed to evaluate predictors for long-term mortality in SE using the Thai national healthcare database. METHODS: This study was conducted using the Thai national Universal Health Coverage (UC) database. The eligibility criteria for this study were that all patients were diagnosed with SE and had been admitted to any hospital between 2005 and 2015...
May 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29778428/status-dystonicus-due-to-missense-variant-in-arx-diagnosis-and-management
#2
Kathleen M Gorman, Heather Cary, Laura Gaffney, Eva Forman, Dympna Waldron, Fowzy Al-Delami, Bryan J Lynch, Mary D King, Nicholas M Allen
Movement disorders are increasingly identified in infantile encephalopathies due to single gene disorders (e.g. SCN2A, CDKL5, ARX). The associated movement disorder can be challenging to recognise and treat. We report a 2 year-old boy with a background history of Ohtahara syndrome due to a missense variant in ARX (the aristaless-related homeobox gene) who subsequently developed status dystonicus. ARX is a transcription factor that plays a critical role in cortical neuronal development and is associated with a range of important neurodevelopmental disorders depending on the site of the pathogenic variant...
May 3, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29774448/the-expression-alteration-of-bc1-rna-and-its-interaction-with-eukaryotic-translation-initiation-factor-eif4a-post-status-epilepticus
#3
Xiangchang Zeng, Wenjing Zong, Qing Gao, Siyu Chen, Lulu Chen, Guirong Zeng, Weihua Huang, Zhenyu Li, Chang Zeng, Yuanyuan Xie, Xiaohui Li, Bo Xiao, Dongsheng-Ouyang, Kai Hu
Abnormal dendritic sprouting and synaptic remodelling are important pathological features of temporal lobe epilepsy. BC1 RNA is a translation repressor involved in the regulation of the dendritic protein synthesis and mRNA transport, which is essential for dendritic development and plasticity. The expression alteration of BC1 RNA in the pilocarpine induced epilepsy model remains unknown. It is unclear if the interactions between BC1 RNA and eukaryotic initiation factor 4A (eIF4A) exists in this model. The purpose of this study was to investigate the expression changes of BC1 RNA and its interactions with eIF4A post-status epilepticus (SE)...
May 17, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29770956/dynamic-changes-of-astrocytes-and-adenosine-signaling-in-rat-hippocampus-in-post-status-epilepticus-model-of-epileptogenesis
#4
Siqi Hong, Tingsong Li, Yuanyuan Luo, Wenjuan Li, Xiaoju Tang, Yuanzhen Ye, Peng Wu, Qiao Hu, Li Cheng, Hengsheng Chen, Li Jiang
It is of great importance to explore the development of epileptogenesis, and the adenosine and adenosine kinase (ADK) system seems to play a key role in this process. The aim of this study is to explore the dynamic changes of astrocytes and adenosine signaling during epileptogenesis in rat hippocampus in a post-status epileptogenesis (SE) model. Rat SE models were built and killed for experiments at 1 day (acute phase of epileptogenesis), 5 days (latent phase), 4 weeks (chronic phase), and 8 weeks (late chronic phase of epileptogenesis) after SE induction...
May 16, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29770676/-treatment-and-nursing-of-a-cysticercosis-patient-with-multiple-foci
#5
Fang Yu-Hua, Deng Ji-Guang
OBJECTIVE: To analyze the relevant data, including medical history, treatment and nursing of one cysticercosis patient with multiple foci in Baise City, so as to provide the evidence for improving the treatment and nursing of cysticercosis in the future. METHODS: The data of diet history, diagnosis, treatment and nursing of the patient were collected and analyzed. RESULTS: The patient was a permanent resident in a cysticercosis high endemic area and had a definite history of eating measly pork...
February 10, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29768694/de-novo-variants-in-rhobtb2-an-atypical-rho-gtpase-gene-cause-epileptic-encephalopathy
#6
Hazrat Belal, Mitsuko Nakashima, Hiroshi Matsumoto, Kenji Yokochi, Mariko Taniguchi-Ikeda, Kazushi Aoto, Mohammed Badrul Amin, Azusa Maruyama, Hiroaki Nagase, Takeshi Mizuguchi, Satoko Miyatake, Noriko Miyake, Kazumoto Iijima, Shigeaki Nonoyama, Naomichi Matsumoto, Hirotomo Saitsu
By whole exome sequencing, we identified three de novo RHOBTB2 variants in three patients with epileptic encephalopathies (EEs). Interestingly, all three patients showed acute encephalopathy (febrile status epilepticus), with magnetic resonance imaging revealing hemisphere swelling or reduced diffusion in various brain regions. RHOBTB2 encodes Rho-related BTB domain-containing protein 2, an atypical Rho GTPase that is a substrate-specific adaptor or itself is a substrate for the Cullin-3 (CUL3)-based ubiquitin/proteasome complex...
May 16, 2018: Human Mutation
https://www.readbyqxmd.com/read/29766039/beneficial-outcome-of-urethane-treatment-following-status-epilepticus-in-a-rat-organophosphorus-toxicity-model
#7
Asheebo Rojas, Wenyi Wang, Avery Glover, Zahra Manji, Yujiao Fu, Raymond Dingledine
The efficacy of benzodiazepines to terminate electrographic status epilepticus (SE) declines the longer a patient is in SE. Therefore, alternative methods for ensuring complete block of SE and refractory SE are necessary. We compared the ability of diazepam and a subanesthetic dose of urethane to terminate prolonged SE and mitigate subsequent pathologies. Adult Sprague Dawley rats were injected with diisopropylfluorophosphate (DFP) to induce SE. Rats were administered diazepam (10 mg/kg, ip) or urethane (0...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29761006/sodium-valproate-compared-to-phenytoin-in-treatment-of-status-epilepticus
#8
Mohammad Reza Amiri-Nikpour, Surena Nazarbaghi, Parisa Eftekhari, Sedra Mohammadi, Sina Dindarian, Mahdi Bagheri, Hozan Mohammadi
Background: Status epilepticus (SE) is a neurological emergency which can be life-threatening. Several medical regimens are used in order to control it. In this study, we intended to evaluate the clinical efficacy and tolerability of sodium valproate and intravenous phenytoin (IV PHT) in the control of SE. Methods: One hundred and ten consecutive patients suffering from benzodiazepine refractory SE who were referred to the emergency ward from March 2014 to March 2015 were randomly divided into two groups...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29758445/intravenous-lacosamide-lcm-in-status-epilepticus-se-weight-adjusted-dose-and-efficacy
#9
Estevo Santamarina, Montserrat González-Cuevas, Manuel Toledo, Marta Jiménez, Juan Luis Becerra, Alex Quílez, Ana Suller, J A Mauri, Ángel Fernández, Ainhoa Marinas, Manuel Quintana, Xavier Salas Puig
BACKGROUND: Some studies suggest higher efficacy of lacosamide (LCM) in status epilepticus (SE) with higher loading doses; however, this weight-adjusted dose has not been evaluated. OBJECTIVE: The objective was to evaluate the relationship between loading weight-adjusted dose and efficacy of LCM in SE. METHODS: A group of patients with SE treated with LCM from Spanish hospitals was examined retrospectively. Demographic data, type of SE, etiology, response rate, last antiepileptic drug (AED) used, treatment line in which LCM was used, total loading dose, and weight-adjusted dose were collected...
May 11, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29754107/amantadine-a-new-treatment-for-refractory-electrical-status-epilepticus-in-sleep
#10
Rujuta B Wilson, Yazan Eliyan, Raman Sankar, Shaun A Hussain
PURPOSE: Electrical status epilepticus in sleep (ESES) is an electrographic abnormality linked to language abnormalities and cognitive dysfunction and specifically associated with Landau-Kleffner syndrome (LKS), the syndrome of continuous spike and wave in slow-wave sleep (CSWS), and autistic regression with epileptiform EEG (AREE). As first-line therapies for treatment of ESES display inadequate efficacy and confer substantial risk, we set out to describe our center's experience with amantadine in the treatment of ESES...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29753573/impact-of-prior-authorization-of-antiepileptic-drugs-in-children-with-epilepsy
#11
Elaine C Wirrell, Alexander J Vanderwiel, Lauren Nickels, Saskia L Vanderwiel, Katherine C Nickels
OBJECTIVE: We assessed how commonly prior authorization results in treatment delay or missed doses in children with epilepsy. METHODS: Parents of 462 children followed in a pediatric epilepsy clinic were surveyed regarding prior authorization in the preceding year. Epilepsy and insurance details were collected. If prior authorization was required, parents were asked whether it resulted in (1) delayed initiation of a newly-prescribed antiepileptic drug, and/or (2) lapse in coverage of a current medication...
April 3, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29751371/status-epilepticus-associated-with-acute-encephalitis-long-term-follow-up-of-functional-and-cognitive-outcomes-in-72-patients
#12
Weibi Chen, Yingying Su, Mengdi Jiang, Gang Liu, Fei Tian, Guoping Ren
BACKGROUND: Continued care in patients with encephalitis and prolonged status epilepticus (SE) is controversial. Limited data is available on the functional and cognitive outcomes. METHODS: In a prospective cohort study from 2007 to 2016, patients with acute encephalitis and SE were reviewed. Long-term outcomes including motor disability (modified Rankin Scale, mRS), daily living skills (activities of daily living, ADL), cognitive ability (modified Telephone Interview for Cognitive Status, TICS-M) and epilepsy sequelae, were evaluated in those survivors at 12-month follow-up...
May 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29751355/targeting-of-microrna-21-5p-protects-against-seizure-damage-in-a-kainic-acid-induced-status-epilepticus-model-via-pten-mtor
#13
Chongyang Tang, Yunhe Gu, Haiyang Wang, Hongmei Wu, Yu Wang, Yao Meng, Zhibin Han, Yifei Gu, Wei Ma, Zhenfeng Jiang, Yuanyuan Song, Meng Na, Dunyue Lu, Zhiguo Lin
OBJECTIVE: Studies have shown that microRNAs play a role in the development of epilepsy by regulating downstream target messenger (m)RNA. The present study aims to determine the changes associated with microRNA-21-5p (miR-21-5p) during epileptogenesis in a kainic acid rat model, and to assess whether the PTEN-mTOR pathway is a target of miR-21-5p. METHOD: Reverse transcription polymerase chain reaction (RT-PCR) was used to examine the quantitative expressions of miR-21-5p and PTEN, and Western blotting was used to test the activity of mTOR in the acute, latent, and chronic stages of epileptogenesis...
May 4, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29749377/p2rx7-mapk1-2-sp1-axis-inhibits-mtor-independent-hspb1-mediated-astroglial-autophagy
#14
Ji-Eun Kim, Ah-Reum Ko, Hye-Won Hyun, Su-Ji Min, Tae-Cheon Kang
Recently, we have reported that heat shock protein B1 (HSPB1) and purinergic receptor P2X7 (P2RX7) are involved in astroglial autophagy (clasmatodendrosis), following status epilepticus (SE). However, the underlying mechanisms of astroglial autophagy have not been completely established. In the present study, we found that the lacking of P2rx7 led to prolonged astroglial HSPB1 induction due to impaired mitogen-activated protein kinase 1/2 (MAPK1/2)-mediated specificity protein 1 (SP1) phosphorylation, following kainic acid-induced SE...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29748743/erythropoietin-and-nrf2-key-factors-in-the-neuroprotection-provided-by-apo-lactoferrin
#15
E T Zakharova, A V Sokolov, N N Pavlichenko, V A Kostevich, I N Abdurasulova, A V Chechushkov, I V Voynova, A Yu Elizarova, N N Kolmakov, M G Bass, I V Semak, A I Budevich, P M Kozhin, N K Zenkov, V M Klimenko, O V Kirik, D E Korzhevskii, E B Menshchikova, V B Vasilyev
Among the properties of lactoferrin (LF) are bactericidal, antianemic, immunomodulatory, antitumour, antiphlogistic effects. Previously we demonstrated its capacity to stabilize in vivo HIF-1-alpha and HIF-2-alpha, which are redox-sensitive multiaimed transcription factors. Various tissues of animals receiving recombinant human LF (rhLF) responded by expressing the HIF-1-alpha target genes, hence such proteins as erythropoietin (EPO), ceruloplasmin, etc. were synthesized in noticeable amounts. Among organs in which EPO synthesis occurred were brain, heart, spleen, liver, kidneys and lungs...
May 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29747930/baseline-and-outcome-assessment-in-pediatric-status-epilepticus
#16
REVIEW
Saba Jafarpour, Coral M Stredny, Juan Piantino, Kevin E Chapman
PURPOSE: To summarize different aspects of short and long-term outcomes associated with SE, including mortality, recurrence, subsequent epilepsy, neurocognitive dysfunction, imaging abnormalities, and health-related quality of life. METHODS: We searched MEDLINE for studies that assessed the short-term and long-term outcome of status epilepticus in pediatric population, including mortality, recurrence of seizure and status epilepticus, neurological, cognitive, or behavioral impairment, and health-related quality of life...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29745347/febrile-infection-related-epilepsy-syndrome-fires-an-overview-of-treatment-and-recent-patents
#17
Kam Lun E Lun Hon, Alexander K C Leung, Alcy R Torres
BACKGROUND: New-onset refractory status epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile infection-related epilepsy syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient...
May 8, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29742585/cardiac-arrest-in-patients-managed-for-convulsive-status-epilepticus-characteristics-predictors-and-outcome
#18
Stephane Legriel, Edouard Bresson, Nicolas Deye, David Grimaldi, Bertrand Sauneuf, Olivier Lesieur, Jean-Baptiste Lascarrou, Laurent Argaud, Jonathan Chelly, Pascal Beuret, David Schnell, Anne-Laure Chateauneuf, Mathilde Holleville, François Perier, Virginie Lemiale, Cedric Bruel, Pierrick Cronier, Nicolas Pichon, Nicolas Mongardon, Nicolas de-Prost, Florence Dumas, Alain Cariou
OBJECTIVES: Cardiac arrest is a catastrophic event that may arise during the management of convulsive status epilepticus. We aimed to report the clinical characteristics, outcomes, and early predictors of convulsive status epilepticus-related cardiac arrest. DESIGN: Retrospective multicenter study. SETTING: Seventeen university or university affiliated participating ICUs in France and Belgium. PATIENTS: Consecutive patients admitted to the participating ICUs for management of successfully resuscitated out-of-hospital cardiac arrest complicating the initial management of convulsive status epilepticus between 2000 and 2015...
May 8, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29739085/cerebral-venous-sinus-thrombosis-with-cerebral-hemorrhage-presenting-with-status-epilepticus-in-early-pregnancy
#19
Xuemin Feng, Teng Zhao, Jingyao Liu, Chunkui Zhou
BACKGROUND: CVST is an important cause of stroke during late pregnancy and in the puerperium, but it is seldom encountered during early pregnancy. We report a case of a 34-year-old woman presenting with convulsive status epilepticus in early pregnancy. METHODS: In this case, the cranial computed tomography detected hemorrhage. Magnetic resonance imaging revealed a bilateral hypointense signal involving the frontal lobes and a hyperintense lesion on the right temporal lobe on T1-weighted imaging, and a large bilateral hyperintense area involving the frontal lobes on T2-weighted and fluid-attenuated inversion recovery imaging...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737480/notch-signaling-regulates-microglial-activation-and-inflammatory-reactions-in-a-rat-model-of-temporal-lobe-epilepsy
#20
Lei Wu, Yushuang Li, Minhua Yu, Fei Yang, Mengqi Tu, Haibo Xu
The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-related neuronal injury during the process of epileptogenesis in a rat model of temporal lobe epilepsy. By using western blotting, real-time quantitative PCR, immunohistochemistry and immunofluorescence labeling, we found that the expression of Notch signaling increased after status epilepticus and that a γ-secretase inhibitor could significantly inhibit the upregulation of Notch signaling, the activation of microglia, and the release of proinflammatory cytokines...
May 8, 2018: Neurochemical Research
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