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https://www.readbyqxmd.com/read/28715816/distinct-dynamics-of-mitotic-transition-in-b-cell-lymphoma-and-reactive-b-cell-lymphoproliferations-determined-by-h3s10-phosphohistone-immunolabeling
#1
Gábor Méhes, Katalin Hegyi, Ravi Jobanputra, Lívia Beke, György Vereb, Judit Bedekovics
OBJECTIVES: Clonal selection in the follicular germinal centers in lymphatic tissues is accompanied by an intense proliferation of polyclonal B cells in a precisely regulated fashion. In contrast, B-cell neoplasias proliferate autonomously due to endogenous stimuli. The cell kinetic activity is obvious at many levels including progressive chromatin modification and elevated mitotic rates. We asked if there are differences in the kinetics of histone H3S10 phosphorylation required for mitotic entry between highly proliferating B cells of reactive germinal centers and in B-cell lymphomas with different proliferative capacity...
July 18, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28713985/microarray-expression-profiles-of-long-non-coding-rnas-in-germinal-center-like-diffuse-large-b-cell-lymphoma
#2
Hong-Yu Gao, Bin Wu, Wei Yan, Zi-Mu Gong, Qi Sun, Hui-Han Wang, Wei Yang
Long non-coding RNAs (lncRNAs) are continuously transcribed and are involved in various cellular activities. However, their contributions to the occurrence and development of germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL) remain largely unknown. We applied microarray technology to profile the expression of lncRNAs in two different GCB-DLBCL cell lines (OCI-ly1 and OCI-ly19) and normal B lymphocytes. We demonstrated that 21,539 lncRNAs were expressed in all of the samples analyzed...
July 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28713371/regulation-of-subunit-specific-germinal-center-b-cell-responses-to-the-hiv-1-envelope-glycoproteins-by-antibody-mediated-feedback
#3
Mattias N E Forsell, Linda Kvastad, Saikiran K Sedimbi, John Andersson, Mikael C I Karlsson
The regulation of germinal center (GC) B cell responses to single epitopes is well investigated. How monoclonal B cells are regulated within the polyclonal B cell response to protein antigens is less so. Here, we investigate the primary GC B cell response after injection of mice with HIV-1 envelope glycoproteins. We demonstrate that single GCs are seeded by a diverse number of B cell clones shortly after a single immunization and that the presence of Env-specific antibodies can inhibit the development of early GC B cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28712455/the-properties-of-the-unique-age-associated-b-cell-subset-reveal-a-shift-in-strategy-of-immune-response-with-age
#4
Susan L Swain, Olivia Kugler-Umana, Yi Kuang, Wenliang Zhang
In aged mice, conventional naive B cells decrease and a new population of age-associated B cells (ABC)(3) develops. When aged unprimed mice are infected with influenza virus, there is a reduced generation of helper CD4 T cell subsets and germinal center B cells, leading to limited production of IgG Ab and less generation of conventional long-lived plasma cells, compared to young. However, we find an enhanced non-follicular (GL7(-)) ABC response that is helper T cell-independent, but requires high viral dose and pathogen recognition pathways...
July 11, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28708292/fhod1-regulates-cytoplasmic-actin-based-spindle-migration-for-mouse-oocyte-asymmetric-cell-division
#5
Meng-Hao Pan, Fei Wang, Yujie Lu, Feng Tang, Xing Duan, Yu Zhang, Bo Xiong, Shao-Chen Sun
FHOD1 is a member of Diaphanous related formins (DRFs) which belongs to the Formin family. Previous studies have shown that the DFRs might affect several cellular functions such as morphogenesis, cytokinesis, cell polarity and embryonic differentiation. However, there is no evidence showing the functions of FHOD1 during oocyte meiosis. This study is aimed at exploring the roles of FHOD1 during the mammalian oocyte maturation. Immunofluorescent staining showed that FHOD1 was restricted to the nucleus in germinal vesicle (GV) stage of the oocytes, after the GV breakdown FHOD1 was primarily located at two poles of the spindle at both metaphase I and metaphase II stages...
July 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28707393/malaria-epstein-barr-virus-infection-and-the-pathogenesis-of-burkitt-s-lymphoma
#6
Anthony R Mawson, Suvankar Majumdar
A geographical and causal connection has long been recognized between malaria, Epstein-Barr virus (EBV) infection and Burkitt's lymphoma (BL), but the underlying mechanisms remain obscure. Potential clues are that the malaria parasite Plasmodium falciparum selectively absorbs vitamin A from the host and depends on it for its biological activities; secondly, alterations in vitamin A (retinoid) metabolism have been implicated in many forms of cancer, including BL. The first author has proposed that the merozoite-stage malaria parasite, emerging from the liver, uses its absorbed vitamin A as a cell membrane destabilizer to invade the red blood cells, causing anemia and other signs and symptoms of the disease as manifestations of an endogenous form of hypervitaminosis A (Mawson AR...
July 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28704473/enriched-environment-and-stress-exposure-influence-splenic-b-lymphocyte-composition
#7
Blake T Gurfein, Burcu Hasdemir, Jeffrey M Milush, Chadi Touma, Rupert Palme, Douglas F Nixon, Nicholas Darcel, Frederick M Hecht, Aditi Bhargava
Prolonged chronic stress has deleterious effects on immune function and is associated with numerous negative health outcomes. The spleen harbors one-fourth of the body's lymphocytes and mediates both innate and adaptive immune responses. However, the subset of splenic lymphocytes that respond, either adaptively or maladaptively, to various stressors remains largely unknown. Here we investigated the effects of unpredictable chronic mild stress (CMS) exposure on spleen composition in male mice housed in two different caging conditions: standard caging (Cntl) and enriched environment (EE)...
2017: PloS One
https://www.readbyqxmd.com/read/28701402/increased-durable-b-cell-and-adcc-responses-associated-with-t-helper-responses-to-hiv-1-envelope-in-macaques-vaccinated-with-gp140-occluded-at-the-cd4-receptor-binding-site
#8
Willy M J M Bogers, Susan W Barnett, Herman Oostermeijer, Ivonne G Nieuwenhuis, Niels Beenhakker, Daniella Mortier, Petra Mooij, Gerrit Koopman, Edmund Remarque, Gregoire Martin, Rachel Pei-Jen Lai, Antu K Dey, Yide Sun, Brian Burke, Guido Ferrari, David Montefiori, Loic Martin, David Davis, Indresh Srivastava, Jonathan L Heeney
Strategies are needed to improve the immunogenicity of HIV-1 envelope (Env) antigens for more long lived, efficacious HIV-1 vaccine induced B-cell responses. HIV-1 Env gp140 (native or un-cleaved molecules) or gp120 monomeric proteins elicit relatively poor B-cell responses which are short-lived. We hypothesized that Env engagement of the CD4 receptor on T-helper cells may result in anergic effects on T-cell recruitment and consequently a lack of strong robust and durable B-memory responses. To test this hypothesis we occluded the CD4 binding site (CD4bs) of gp140 by stable cross-linking with a 3kD CD4 miniprotein mimetic serving to block ligation of gp140 on CD4+T-cells while preserving CD4 inducible (CDi) neutralizing and epitopes targeted by antibody dependent cellular cytotoxic (ADCC) effector responses...
July 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28700710/t-follicular-helper-cells-regulate-the-activation-of-b-lymphocytes-and-antibody-production-during-plasmodium-vivax-infection
#9
Maria Marta Figueiredo, Pedro Augusto Carvalho Costa, Suelen Queiroz Diniz, Priscilla Miranda Henriques, Flora Satiko Kano, Mauro Sugiro Tada, Dhelio Batista Pereira, Irene Silva Soares, Olindo Assis Martins-Filho, Dragana Jankovic, Ricardo Tostes Gazzinelli, Lis Ribeiro do Valle Antonelli
Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been proposed that expansion of antigen-specific Tfh cells, interleukin (IL) 21 production and robust germinal center formation are associated with protection against malaria in mice, whether Tfh cells are found during Plasmodium vivax (P. vivax) infection and if they play a role during disease remains unknown...
July 10, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28698369/a-distinct-subpopulation-of-cd25-t-follicular-regulatory-cells-localizes-in-the-germinal-centers
#10
James Badger Wing, Yohko Kitagawa, Michela Locci, Hannah Hume, Christopher Tay, Takayoshi Morita, Yujiro Kidani, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, Shimon Sakaguchi
T-follicular helper (Tfh) cells differentiate through a multistep process, culminating in germinal center (GC) localized GC-Tfh cells that provide support to GC-B cells. T-follicular regulatory (Tfr) cells have critical roles in the control of Tfh cells and GC formation. Although Tfh-cell differentiation is inhibited by IL-2, regulatory T (Treg) cell differentiation and survival depend on it. Here, we describe a CD25(-) subpopulation within both murine and human PD1(+)CXCR5(+)Foxp3(+) Tfr cells. It is preferentially located in the GC and can be clearly differentiated from CD25(+) non-GC-Tfr, Tfh, and effector Treg (eTreg) cells by the expression of a wide range of molecules...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28692537/early-initiation-of-antiretroviral-treatment-post-siv-infection-does-not-resolve-lymphoid-tissue-activation
#11
Jung Joo Hong, Eduardo L V Silveira, Praveen K Amancha, Siddappa N Byrareddy, Sanjeev Gumber, Kyu-Tae Chang, Aftab A Ansari, Francois Villinger
OBJECTIVE: Germinal center (GC) resident follicular helper T (TFH) cells in lymphoid follicles are a potential sanctuary for HIV/SIV replication. But the dynamics of GCs upon early initiation of antiretroviral therapy (ART) and their potential role in the formation of viral sanctuaries post SIV infection are not fully understood. DESIGN: Sequential lymph node biopsies (n = 10) were collected from SIVmac239-infected rhesus macaques before infection, at 5 weeks post infection/pre ART, 6 and 12 weeks following ART initiation...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28690949/role-of-sex-hormone-levels-and-psychological-stress-in-the-pathogenesis-of-autoimmune-diseases
#12
REVIEW
Salman Assad, Hamza H Khan, Haider Ghazanfar, Zarak H Khan, Salman Mansoor, Muhammad A Rahman, Ghulam H Khan, Bilal Zafar, Usman Tariq, Shuja A Malik
The aim of this review article is to assess the connection between psychological stress and sex hormones and their effect on the development of autoimmune diseases. Psychological stress describes what people feel when they are under mental, physical, or emotional pressure. We searched for online articles using MEDLINE®, Embase, Cochrane Library and Google Scholar. Our research yielded a total of 165 articles out of which 30 articles were considered for further perusal. The articles were reviewed from February 2016 to February 2017...
June 5, 2017: Curēus
https://www.readbyqxmd.com/read/28690525/primary-type3-non-abc-non-gcb-subtype-of-extranodal-diffuse-large-b-cell-lymphoma-of-the-thyroid-bearing-no-myd88-mutation-by-padlock-probe-hybridization
#13
Yukiko Nishi, Riko Kitazawa, Ryuma Haraguchi, Ayaka Ouchi, Yasuo Ueda, Yuri Kamaoka, Ken Yamamoto, Yasuhiko Todo, Hiroaki Miyaoka, Sohei Kitazawa
Primary extranodal malignant lymphoma of the thyroid is a rare entity composed of mostly neoplastic transformation of germinal center-like B cells (GCB) or memory B cells. Other B-cell-type malignancies arising primarily in the thyroid have rarely been described. Immunohistochemical examination of autopsied primary malignant lymphoma of the thyroid in an 83-year-old Japanese female revealed the presence of a non-GCB subtype of diffuse large B-cell lymphoma (DLBCL) without the typical codon 206 or 265 missense mutation of MYD88...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28690324/proteasome-inhibition-suppresses-th17-cell-generation-and-ameliorates-autoimmune-development-in-experimental-sj%C3%A3-gren-s-syndrome
#14
Fan Xiao, Xiang Lin, Jie Tian, Xiaohui Wang, Qian Chen, Ke Rui, Jie Ma, Shengjun Wang, Qingwen Wang, Xiaoqi Wang, Dongzhou Liu, Lingyun Sun, Liwei Lu
Immunoproteasome activation in immune cells is involved in the modulation of immune responses. Increasing evidence indicates that proteasome inhibitors show beneficial effects in treating autoimmune diseases, but it remains unclear whether proteasome inhibition is an effective approach for suppressing autoimmune development in Sjögren's syndrome (SS). Our previous work has demonstrated a critical role for Th17 cells in the development of experimental SS (ESS) in mice. In this study, we detected high levels of low-molecular-weight protein 7 (LMP7), a key subunit of the immunoproteasome, in Th17 cells from ESS mice...
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28689360/regulatory-myeloid-cells-an-underexplored-continent-in-b-cell-lymphomas
#15
REVIEW
Mikael Roussel, Jonathan M Irish, Cedric Menard, Faustine Lhomme, Karin Tarte, Thierry Fest
In lymphomas arising from the germinal center, prognostic factors are linked to the myeloid compartment. In particular, high circulating monocyte or myeloid-derived suppressor cell counts are associated with poor prognosis for patients with high-grade B-cell lymphomas. Macrophages with an M2 phenotype are enriched within lymphoma tumors. However, the M1/M2 nomenclature is now deprecated and the clinical impact of this phenotype remains controversial. Across cancer types, myeloid cells are primarily thought to function as immune suppressors during tumor initiation and maintenance, but the biological mechanisms behind the myeloid signatures are still poorly understood in germinal center B-cell lymphomas...
July 8, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28688665/b-cells-in-tertiary-lymphoid-structures-are-associated-with-favorable-prognosis-in-gastric-cancer
#16
Chie Sakimura, Hiroaki Tanaka, Takahiro Okuno, Soichiro Hiramatsu, Kazuya Muguruma, Kosei Hirakawa, Hideki Wanibuchi, Masaichi Ohira
BACKGROUND: The role of tumor-infiltrating B cells in the tumor microenvironment is still unclear. Recent studies have reported that B cells and tertiary lymphoid structures (TLSs) that contain B cell follicles correlate with the favorable prognosis of cancer patients. The aim of this study was to investigate the association between tumor-infiltrating B cells and clinicopathological features in gastric cancer. METHODS: Tumor blocks were obtained from 226 patients with stage Ib to stage IV gastric cancer...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28687657/antigen-acquisition-enables-newly-arriving-b-cells-to-enter-ongoing-immunization-induced-germinal-centers
#17
Jackson S Turner, Zachary L Benet, Irina L Grigorova
Modern vaccines must be designed to generate long-lasting, high-affinity, and broadly neutralizing Ab responses against pathogens. The diversity of B cell clones recruited into germinal center (GC) responses is likely to be important for the Ag-neutralization potential of the Ab-secreting cells and memory cells generated upon immunization. However, the factors that influence the diversity of B cell clones recruited into GCs are unclear. As recirculating naive Ag-specific B cells arrive in Ag-draining secondary lymphoid organs, they may join the ongoing GC response...
July 7, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28686488/contribution-of-both-b-cell-intrinsic-alterations-as-well-as-non-hematopoietic-derived-factors-in-the-enhanced-immune-response-of-the-nod-mouse
#18
Viqar Showkat Banday, Radha Thyagarajan, Kristina Lejon
The underlying cellular and molecular mechanism for the development of Type 1 diabetes is still to be fully revealed. We have previously demonstrated that the NOD mouse, a model for Type 1 diabetes, display a prolonged and enhanced immune response to both self and non-self-antigens. The molecular explanation for this defect however, has not been determined. In this study we immunized NOD and C57BL/6 (B6) with the conventional antigen i.e. hen egg lysozyme (HEL) and analyzed B cell activation, germinal center reaction and antibody clearance...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28685417/the-lymph-node-in-hiv-pathogenesis
#19
REVIEW
Yiannis Dimopoulos, Eirini Moysi, Constantinos Petrovas
Lymph nodes play a central role in the development of adaptive immunity against pathogens and particularly the generation of antigen-specific B cell responses in specialized areas called germinal centers (GCs). Lymph node (LN) pathology was recognized as an important consequence of human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. Investigation into the structural and functional alterations induced by HIV and Simian immunodeficiency virus (SIV) has further cemented the central role that lymphoid tissue plays in HIV/SIV pathogenesis...
July 7, 2017: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/28684330/spindle-cell-variant-of-primary-cutaneous-follicle-center-b-cell-lymphomas-are-germinal-center-b-cell-lymphomas-by-gene-expression-profiling-using-formalin-fixed-paraffin-embedded-specimen
#20
Ilske Oschlies, Christian W Kohler, Monika Szczepanowski, Karoline Koch, Artur Gontarewicz, Dieter Metze, Uwe Hillen, Julia Richter, Rainer Spang, Wolfram Klapper
No abstract text is available yet for this article.
July 3, 2017: Journal of Investigative Dermatology
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