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https://www.readbyqxmd.com/read/28736997/distinct-histopathologic-features-of-radiation-induced-chronic-sinusitis
#1
Hannah N Kuhar, Bobby A Tajudeen, Ashley Heilingoetter, Mahboobeh Mahdavinia, Paolo Gattuso, Ritu Ghai, Ferry Gunawan, Aidnag Z Diaz, George Tolekidis, Pete S Batra
BACKGROUND: Chronic rhinosinusitis (CRS) is a commonly observed sequela after radiation therapy to the paranasal sinuses. The histopathologic features of radiation-induced CRS have yet to be determined and may have major implications in disease management. METHODS: A structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Histopathology variables, Lund-Mackay score (LMS), and 22-item Sino-Nasal Outcome Test (SNOT-22) scores were compared among patients with radiation-induced CRS (CRSr), CRS without nasal polyps (CRSsNP), and CRS with nasal polyps (CRSwNP)...
July 24, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28687917/the-application-of-surgical-procedure-manager-spm-first-experience-with-fess
#2
Katharina Feige, Iris Gollnick, Pia Schmitz, Gero Strauss
In our hypothesis, the newly developed program SPM (surgical procedure manager) will ensure successful standardization and efficiency of the FESS (functional endoscopic sinus surgery) and therefore make a decisive contribution in terms of economization and improvement of intraoperative quality. Between 27th March 2015 and 8th October 2015, data from 259 FESS procedures were collected using the SPM. The study took place at the surgical desk, an operating room in the ACQUA clinic in Leipzig, Germany. 233 FESS (90%) of the total FESS (n = 259, 100%) were conducted entirely with SPM...
July 7, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28669043/the-xpress-multi-sinus-dilation-system-for-the-treatment-of-chronic-sinusitis-a-nice-medical-technology-guidance
#3
REVIEW
Michelle Jenks, Iain Willits, Emily Eaton Turner, Neil Hewitt, Mick Arber, Helen Cole, Joyce Craig, Andrew Sims
The XprESS multi-sinus dilation system (XprESS) is a minimally invasive alternative to functional endoscopic sinus surgery (FESS) used in the treatment of people with chronic or recurrent acute sinusitis refractory to medical treatment. The manufacturer of XprESS, Entellus Medical, claims the technology is as effective as FESS in improving quality of life and is associated with quicker recovery times and reduced costs. The Medical Technologies Advisory Committee (MTAC) at the National Institute for Health and Care Excellence (NICE) selected XprESS for evaluation...
July 1, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28636087/extended-inferior-antrostomy-for-maxillary-sinus-surgery
#4
Justin Michel, Thomas Radulesco, Martin Penicaud, Patrick Dessi
Functional endoscopic sinus surgery (FESS) has considerably evolved over the past 20 years while minimally-invasive surgery also applies to sinus procedures. Development of new technologies combined with better knowledge of risks has allowed surgeons to achieve improved results in their FESS indications. One of the most difficult areas to visualize using the exclusive endoscopic approach is still the anterior recess of the maxillary sinus. Hence, external approaches, such as the Caldwell-Luc procedure, are still used by many surgeons to ensure visual control of this area in diseases such as fungal balls, mucoceles, inverted papilloma and other tumors...
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28634293/intrinsic-map-dynamics-exploration-for-uncharted-effective-free-energy-landscapes
#5
Eliodoro Chiavazzo, Roberto Covino, Ronald R Coifman, C William Gear, Anastasia S Georgiou, Gerhard Hummer, Ioannis G Kevrekidis
We describe and implement a computer-assisted approach for accelerating the exploration of uncharted effective free-energy surfaces (FESs). More generally, the aim is the extraction of coarse-grained, macroscopic information from stochastic or atomistic simulations, such as molecular dynamics (MD). The approach functionally links the MD simulator with nonlinear manifold learning techniques. The added value comes from biasing the simulator toward unexplored phase-space regions by exploiting the smoothness of the gradually revealed intrinsic low-dimensional geometry of the FES...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28598713/robot-assisted-endoscope-guidance-versus-manual-endoscope-guidance-in-functional-endonasal-sinus-surgery-fess
#6
Klaus Wolfgang Eichhorn, Ralf Westphal, Markus Rilk, Carsten Last, Friedrich Bootz, Friedrich Wahl, Mark Jakob, Thorsten Send
BACKGROUND: Having one hand occupied with the endoscope is the major disadvantage for the surgeon when it comes to functional endoscopic sinus surgery (FESS). Only the other hand is free to use the surgical instruments. Tiredness or frequent instrument changes can thus lead to shaky endoscopic images. METHODS: We collected the pose data (position and orientation) of the rigid 0° endoscope and all the instruments used in 16 FESS procedures with manual endoscope guidance as well as robot-assisted endoscope guidance...
June 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28595999/p63-transcription-factor-regulates-nuclear-shape-and-expression-of-nuclear-envelope-associated-genes-in-epidermal-keratinocytes
#7
Valentina Rapisarda, Igor Malashchuk, Inemo E Asamaowei, Krzysztof Poterlowicz, Michael Y Fessing, Andrey A Sharov, Iakowos Karakesisoglou, Vladimir A Botchkarev, Andrei Mardaryev
The maintenance of a proper nuclear architecture and 3D organization of the genes, enhancer elements and transcription machinery plays an essential role in tissue development and regeneration. Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by marked decrease in expression of several nuclear envelop-associated components (Lamin B1, Lamin A/C, SUN1, Nesprin-3, Plectin) compared to controls. Furthermore, ChIP-qPCR assay showed enrichment of p63 on Sun1, Syne3 and Plec promoters, suggesting them as p63 targets...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28584352/intravenous-clonidine-as-a-part-of-balanced-anaesthesia-for-controlled-hypotension-in-functional-endoscopic-sinus-surgery-a-randomised-controled-trial
#8
Meghna Jiwanmall, Anita Shirley Joselyn, Subramani Kandasamy
BACKGROUND AND AIMS: Controlled hypotension with balanced anaesthesia minimises blood loss. This study was done to evaluate the effectiveness of intravenous clonidine as a single bolus dose to establish controlled hypotension during functional endoscopic sinus surgery (FESS). METHODS: This randomised, double-blind, placebo-controlled study was done in a tertiary hospital in India. Sixty American Society of Anesthesiologists physical status I and II patients (18-65 years) undergoing FESS were randomly allocated to one of the two groups...
May 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28583234/bilateral-silent-sinus-syndrome-a-rare-case-and-review-of-literature
#9
Michal Trope, Joseph S Schwartz, Bobby A Tajudeen, David W Kennedy
OBJECTIVE: In this report, we presented a rare case of bilateral silent sinus syndrome (SSS) in an otherwise healthy 57-year-old man treated with functional endoscopic sinus surgery (FESS). A systematic review of the literature regarding bilateral SSS was performed. CASE REPORT: A 57-year-old man with well-controlled allergic rhinitis in the absence of previous surgery or trauma presented with bilateral SSS, which was successfully managed with bilateral FESS. METHODS: A medical literature data base search of the terms "silent sinus syndrome" "maxillary atelectasis," "imploding antrum syndrome," and "bilateral silent sinus syndrome" was performed...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28544530/denatonium-induced-sinonasal-bacterial-killing-may-play-a-role-in-chronic-rhinosinusitis-outcomes
#10
Ryan M Carey, Alan D Workman, Kyle M Hatten, Adam P Siebert, Steven G Brooks, Bei Chen, Nithin D Adappa, James N Palmer, David W Kennedy, Robert J Lee, Noam A Cohen
BACKGROUND: Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericidal antimicrobial peptides (AMPs) in neighboring ciliated epithelial cells. We hypothesized that there is patient variability in the amount of bacterial killing induced by different concentrations of denatonium and that the differences correlate with CRS clinical outcomes...
July 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28523084/survey-of-current-practice-patterns-in-the-management-of-frontal-sinus-fractures
#11
Kevin J Choi, Bora Chang, Charles R Woodard, David B Powers, Jeffrey R Marcus, Liana Puscas
The management of frontal sinus fractures has evolved in the endoscopic era. The development of functional endoscopic sinus surgery (FESS) has been incorporated into management algorithms proposed by otolaryngologists, but the extent of its influence on plastic surgeons and oral and maxillofacial surgeons is heretofore unknown. A cross-sectional survey was performed to assess the practice pattern variations in frontal sinus fracture management across multiple surgical disciplines. A total of 298 surveys were reviewed...
June 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28523041/functional-endoscopic-sinus-surgery-as-a-primary-modality-of-treatment-for-primary-and-recurrent-nasal-polyposis
#12
Mohammad Shahid Gohar, Saleem Asif Niazi, Sohail Baber Niazi
OBJECTIVES: To describe the efficacy of Functional Endoscopic Sinus Surgery(FESS) in our set up in comparison with other published studies to treat primary and recurrent nasal polyposis. METHOD: This descriptive study was conducted in 02 years at Ear Nose Throat Department Combined Military Hospital (CMH) Multan from October 2013 to October 2015. Convenient sample comprising 116 patients of both sexes of age group from 18 to 60 years were selected from ENT Out Patient Department, with documented diagnosis of nasal polyposis that underwent functional endoscopic sinus surgery...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28492611/the-effect-of-topical-treatments-for-crs-on-the-sinonasal-epithelial-barrier
#13
M Ramezanpour, A Rayan, J L P Smith, S Vreugde
BACKGROUND: Several topical treatments are used in the management of Chronic Rhinosinusitis (CRS), some of which the safety and efficacy has yet to be determined. The purpose of this study was to investigate the effect of commonly used topical treatments on the sinonasal epithelial barrier. METHODS: Normal saline (0.9% Sodium Chloride), hypertonic saline (3% Sodium Chloride), FESS Sinu-Cleanse Hypertonic, FLO Sinus Care and Budesonide 1 mg/ 2 ml were applied to the apical side of air-liquid interface (ALI) cultures of primary human nasal epithelial cells (HNECs) from CRS patients (n=3) and non-CRS controls (n=3) for 24 hours...
June 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28481017/use-of-balloon-sinuplasty-in-patients-with-chronic-rhinosinusitis-in-the-united-states
#14
Mohamad R Chaaban, Jacques G Baillargeon, Gwen Baillargeon, Vicente Resto, Yong-Fang Kuo
BACKGROUND: Over the past decade, the use of balloon sinuplasty has increased widely in the United States. Since its introduction, no nationally representative, population-based study has examined its use among chronic rhinosinusitis (CRS) patients. METHODS: We conducted a retrospective cohort study of patients diagnosed with CRS between 2011 and 2014, and compared the prevalence of conventional functional endoscopic sinus surgery (FESS), balloon sinuplasty, and hybrid sinus surgery according to surgical site and calendar year...
June 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28456848/range-of-s-100%C3%AE-levels-during-functional-endoscopic-sinus-surgery-with-moderately-controlled-hypotension
#15
Youngsuk Kwon, Ji Su Jang, Sung Mi Hwang, Jae Jun Lee, Jun Ho Lee, Sungmin Joo, In-Gon Lee, Sung Jun Hong
The aim of this study is to determine the range of S-100β levels during functional endoscopic sinus surgery (FESS) when the mean arterial pressure (MAP) was controlled within 60-70 mmHg. After anesthesia induction with propofol and remifentanil, the patient was positioned in the reverse Trendelenburg position and MAP was controlled within 60-70 mmHg during surgery. For the S-100β assay, blood was taken from a radial arterial catheter before (baseline) and at 20 (T 20) and 60 (T 60) min after setting the reverse Trendelenburg position and controlled hypotension, and at 60 (T post60) min after the end of the operation...
April 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28441365/efficacy-and-safety-of-3-nasal-packing-materials-used-after-functional-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-a-comparative-study-in-china
#16
Xi-Ling Zheng, Yu-Xiang Zhao, Min Xu
BACKGROUND This study aimed to investigate the efficacy and safety of 3 nasal packing products (silicone tube, Beschitin-F, and Aquacel1-Ag) after functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis (CRS) patients in China. MATERIAL AND METHODS Sixty-six CRS patients undergoing FESS surgery were randomly divided into 3 groups (22 patients in each group): the silicone tube group, the Beschitin-F group, and the Aquacel1-Ag group. Postoperative headache, nasal pain, nasal bleeding, and swelling of the nasal mucosa were observed at 1 month after FESS surgery...
April 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28393053/the-effect-of-topical-tranexamic-acid-on-bleeding-reduction-during-functional-endoscopic-sinus-surgery
#17
Mohammad Hossein Baradaranfar, Mohammad Hossein Dadgarnia, Hossein Mahmoudi, Nasim Behniafard, Saeid Atighechi, Vahid Zand, Amin Baradaranfar, Sedighe Vaziribozorg
INTRODUCTION: Bleeding is a common concern during functional endoscopic sinus surgery (FESS) that can increase the risk of damage to adjacent vital elements by reducing the surgeon's field of view. This study aimed to explore the efficacy of topical tranexamic acid in reducing intraoperative bleeding. MATERIALS AND METHODS: This double-blind, randomized clinical trial was conducted in 60 patients with chronic rhinosinusitis with polyposis (CRSwP) who underwent FESS...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28382115/nasalance-changes-following-various-endonasal-surgeries
#18
Hazem Saeed Amer, Ahmed Shaker Elaassar, Ahmad Mohammad Anany, Amal Saeed Quriba
Introduction There is change in nasalance post endonasal surgery which is not permanent. Objectives The objective of this study is to evaluate the long-term nasalance changes following different types of endonasal surgeries. Methods We included in this study patients who underwent sinonasal surgery at the Otorhinolaryngology Department in Zagazig University Hospitals from February 2015 until March 2016. We divided the patients into two groups according to the surgeries they underwent: Group (A) was the FESS group and group (B), the septoturbinoplasty group...
April 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28381324/quality-of-life-improvement-after-endoscopic-sinus-surgery-in-patients-with-obstructive-sleep-apnea
#19
Bobby A Tajudeen, Steven G Brooks, Carol H Yan, Edward C Kuan, Joseph S Schwartz, Jeffrey D Suh, James N Palmer, Nithin D Adappa
BACKGROUND: There is preliminary evidence that patients with chronic rhinosinusitis (CRS) and comorbid obstructive sleep apnea (OSA) have reduced quality-of-life (QOL) improvements after functional endoscopic sinus surgery (FESS) compared with patients without OSA. The effect of OSA severity on QOL improvement after FESS is unknown. OBJECTIVES: To better characterize the QOL improvement after FESS for patients with comorbid OSA and to assess whether QOL improvement is dependent on OSA severity...
March 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28296272/ergonomic-analysis-of-the-surgical-position-in-functional-endoscopic-sinus-surgery
#20
Vijay R Ramakrishnan, Benjamin M Milam
BACKGROUND: Ergonomics is the methodologic study of people's efficiency in their work environment and is based on anatomy, physiology, psychology, and engineering. Although highly studied in other work environments, little attention has been paid to surgeons until the landmark survey by Park et al in 2010. Many unique aspects of endoscopic surgery amplify task-related physical discomfort, and, because of these issues, we aimed to study the physical fatigue effects of functional endoscopic sinus surgery (FESS) performed in the standing and sitting positions...
June 2017: International Forum of Allergy & Rhinology
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