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https://www.readbyqxmd.com/read/28640896/beneficial-effects-of-a-gait-used-while-wearing-a-kimono-to-decrease-the-knee-adduction-moment-in-healthy-adults
#1
Susumu Ota, Yukari Ogawa, Hiroki Ota, Tomoya Fujiwara, Tadashi Sugiyama, Akira Ochi
The knee adduction moment (KAM) relates to medial knee osteoarthritis (OA). Several gait modifications to reduce the KAM for the prevention of knee OA have been studied. Most of the modifications, however, involve voluntary changes in leg alignment. Here we investigated the biomechanical effects for reducing the KAM of a walking style with a small trunk rotation and arm swing gait, which is a natural walking style used while wearing a kimono (Nanba walk) that shifts the ground reaction force toward the stance leg (reduced lever arm)...
2017: PloS One
https://www.readbyqxmd.com/read/28637183/nuclitrack-an-integrated-nuclei-tracking-application
#2
Sam Cooper, Alexis R Barr, Robert Glen, Chris Bakal
Summary: Live imaging studies give unparalleled insight into dynamic single cell behaviours and fate decisions. However, the challenge of reliably tracking single cells over long periods of time limits both the throughput and ease with which such studies can be performed. Here, we present NucliTrack, a cross platform solution for automatically segmenting, tracking and extracting features from fluorescently-labelled nuclei. NucliTrack performs similarly to other state-of-the-art cell tracking algorithms, but NucliTrack's interactive, graphical interface makes it significantly more user friendly...
June 20, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28633441/bioqueue-a-novel-pipeline-framework-to-accelerate-bioinformatics-analysis
#3
Li Yao, Heming Wang, Yuanyuan Song, Guangchao Sui
Motivation: With the rapid development of Next-Generation Sequencing, a large amount of data is now available for bioinformatics research. Meanwhile, the presence of many pipeline frameworks makes it possible to analyse these data. However, these tools concentrate mainly on their syntax and design paradigms, and dispatch jobs based on users' experience about the resources needed by the execution of a certain step in a protocol. As a result, it is difficult for these tools to maximize the potential of computing resources, and avoid errors caused by overload, such as memory overflow...
June 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28630826/predicting-the-effects-of-interventions-a-tutorial-on-the-disequilibrium-model
#4
Kenneth W Jacobs, Zachary H Morford, James E King, Linda J Hayes
The disequilibrium approach to reinforcement and punishment, derived from the probability-differential hypothesis and response deprivation hypothesis, provides a number of potentially useful mathematical models for practitioners. The disequilibrium approach and its accompanying models have proven effective in the prediction and control of behavior, yet they have not been fully espoused and integrated into clinical practice. The purpose of this tutorial is to detail the disequilibrium approach and adapt its mathematical models for use as a tool in applied settings...
June 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/28629995/intraosseous-compared-to-intravenous-drug-resuscitation-in-out-of-hospital-cardiac-arrest
#5
Bryan A Feinstein, Benjamin A Stubbs, Tom Rea, Peter J Kudenchuk
AIMS: Although the intraosseous (IO) route is increasingly used for vascular access in out-of-hospital cardiac arrest (OHCA), little is known about its comparative effectiveness relative to intravenous (IV) access. We evaluated clinical outcomes following OHCA comparing drug administration via IO versus IV routes. METHODS: This retrospective cohort study evaluated Emergency Medical Services (EMS)-treated adults with atraumatic OHCA in a large metropolitan EMS system between 9/1/2012-12/31/2014...
June 16, 2017: Resuscitation
https://www.readbyqxmd.com/read/28629337/validity-and-reliability-of-electroacoustic-probe-for-diagnosis-of-developmental-dysplasia-of-the-hip
#6
Nicolas Padilla-Raygoza, Georgina Olvera-Villanueva, Silvia Del Carmen Delgado-Sandoval, Teodoro Cordova-Fraga, Modesto Antonio Sosa-Aquino, Vicente Beltran-Campos
BACKGROUND: Sound transmission is used in the diagnosis of hip dysplasia since the end of the 80's. Aim of this study is to quantify the validity and reliability of electroacoustic probe for the diagnosis of hip dysplasia in neonates. METHODS: Diagnostic study included neonates aged 4-28 days, whose parents signed an informed consent. The probe was used three times for comparative sound transmission and with extension/flexion; hip ultrasound was performed with Graf technique as gold standard...
June 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28624044/predictors-of-a-histopathologic-diagnosis-of-complicated-appendicitis
#7
Jonathan B Imran, Tarik D Madni, Christian T Minshall, Ali A Mokdad, Madhu Subramanian, Audra T Clark, Herb A Phelan, Michael W Cripps
BACKGROUND: Despite its utilization, the intraoperative (IO) assessment of complicated appendicitis (CA) is subjective. The histopathologic (HP) diagnosis should be the gold standard in identifying patients with CA; however, it is not immediately available to guide postoperative management. The objective of this study was to identify predictors of an HP diagnosis of CA. MATERIALS AND METHODS: A retrospective review of all patients who underwent appendectomy at our institution from 2011-2013 was conducted...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28605460/modmaps3d-an-interactive-webtool-for-the-quantification-and-3d-visualization-of-interrelationships-in-a-dataset-of-dna-sequences
#8
Rallis Karamichalis, Lila Kari
Summary: MoDMaps3D (Molecular Distance Maps 3D) is an alignment-free, fast, computationally lightweight webtool for computing and visualizing the interrelationships within any dataset of DNA sequences, based on pairwise comparisons between their oligomer compositions. MoDMaps3D is a general-purpose interactive webtool that is free of any requirements on sequence composition, position of the sequences in their respective genomes, presence or absence of similarity or homology, sequence length, or even sequence origin (biological or computer-generated)...
June 10, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28598835/efficacy-of-contrast-enhanced-ultrasound-for-immediate-assessment-of-ablation-status-after-intraoperative-radiofrequency-ablation-of-hepatic-malignancies
#9
N Platz Batista da Silva, L P Beyer, M C Hottenrott, C Hackl, H J Schlitt, C Stroszczynski, P Wiggermann, E M Jung
AIM: To evaluate the Efficacy of intraoperative contrast enhanced ultrasound (Io-CEUS) for assessment of radiofrequency ablation (RFA) during liver tumor surgery. MATERIAL AND METHODS: Retrospective analyis was performed on 18 patients who underwent combined liver tumor surgery and RFA of 27 hepatic tumors between 02/2011 and 12/2016. Io-CEUS was performed by bolus injections of up to 10 ml sulphur hexaflourid microbubbles for diagnostic purposes. To guide the RFA up to 20 ml microbubbles were applied to monitor the procedure and assess the ablation status finally...
June 3, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28586299/inter-fork-strand-annealing-causes-genomic-deletions-during-the-termination-of-dna-replication
#10
Carl A Morrow, Michael O Nguyen, Andrew Fower, Io Nam Wong, Fekret Osman, Claire Bryer, Matthew C Whitby
Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. Replication fork barriers are a commonly encountered problem, which can cause fork collapse and act as hotspots for replication termination. Collapsed forks can be rescued by homologous recombination, which restarts replication. However, replication restart is relatively slow and, therefore, replication termination may frequently occur by an active fork converging on a collapsed fork...
June 6, 2017: ELife
https://www.readbyqxmd.com/read/28585071/impact-of-non-transferrin-bound-iron-ntbi-in-comparison-to-serum-ferritin-on-outcome-after-allogeneic-stem-cell-transplantation-asct
#11
Annekathrin Hilken, Claudia Langebrake, Christine Wolschke, Jan Felix Kersten, Holger Rohde, Peter Nielsen, Nicolaus Kröger
The optimal parameters and time points for the measurement of iron overload (IO) in allogeneic stem cell transplantation (ASCT) patients are still under discussion. Hyperferritinemia and IO are poor prognostic factors in ASCT. We hypothesize that non-transferrin-bound iron (NBTI) is possibly a better marker to predict the effect of IO on the outcome than serum ferritin (SF), which however is not specific for IO. The aim of this prospective observational trial was to evaluate the influence of NBTI in comparison to SF on the outcome of ASCT patients [overall survival, bloodstream infections (BSIs), and invasive fungal infections (IFIs)]...
June 6, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28582897/reflex-mediated-dynamic-neuromuscular-stabilization-in-stroke-patients-emg-processing-and-ultrasound-imaging
#12
Hyun S Yoon, Joshua Sung H You
BACKGROUND: Postural core instability is associated with poor dynamic balance and a high risk of serious falls. Both neurodevelopmental treatment (NDT) and dynamic neuromuscular stabilization (DNS) core stabilization exercises have been used to improve core stability, but the outcomes of these treatments remain unclear. OBJECTIVE: This study was undertaken to examine the therapeutic effects of NDT and DNS core stabilization exercises on muscular activity, core stability, and core muscle thickness...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28581558/effects-of-halogens-on-european-air-quality
#13
T Sherwen, M J Evans, R Sommariva, L D J Hollis, S M Ball, P S Monks, C Reed, L J Carpenter, J D Lee, G Forster, B Bandy, C E Reeves, W J Bloss
Halogens (Cl, Br) have a profound influence on stratospheric ozone (O3). They (Cl, Br and I) have recently also been shown to impact the troposphere, notably by reducing the mixing ratios of O3 and OH. Their potential for impacting regional air-quality is less well understood. We explore the impact of halogens on regional pollutants (focussing on O3) with the European grid of the GEOS-Chem model (0.25° × 0.3125°). It has recently been updated to include a representation of halogen chemistry. We focus on the summer of 2015 during the ICOZA campaign at the Weybourne Atmospheric Observatory on the North Sea coast of the UK...
June 5, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28581496/differential-analysis-of-rna-seq-incorporating-quantification-uncertainty
#14
Harold Pimentel, Nicolas L Bray, Suzette Puente, Páll Melsted, Lior Pachter
We describe sleuth (http://pachterlab.github.io/sleuth), a method for the differential analysis of gene expression data that utilizes bootstrapping in conjunction with response error linear modeling to decouple biological variance from inferential variance. sleuth is implemented in an interactive shiny app that utilizes kallisto quantifications and bootstraps for fast and accurate analysis of data from RNA-seq experiments.
June 5, 2017: Nature Methods
https://www.readbyqxmd.com/read/28575203/structurexplor-a-platform-for-the-exploration-of-structural-features-of-rna-secondary-structures
#15
Jean-Pierre Séhi Glouzon, Jean-Pierre Perreault, Shengrui Wang
Summary: Discovering function-related structural features, such as the cloverleaf shape of transfer RNA secondary structures, is essential to understand RNA function. With this aim, we have developed a platform, named Structurexplor, to facilitate the exploration of structural features in populations of RNA secondary structures. It has been designed and developed to help biologists interactively search for, evaluate and select interesting structural features that can potentially explain RNA functions...
May 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28575171/karyoploter-an-r-bioconductor-package-to-plot-customizable-genomes-displaying-arbitrary-data
#16
Bernat Gel, Eduard Serra
Motivation: Data visualization is a crucial tool for data exploration, analysis and interpretation. For the visualization of genomic data there lacks a tool to create customizable non-circular plots of whole genomes from any species. Results: We have developed karyoploteR, an R/Bioconductor package to create linear chromosomal representations of any genome with genomic annotations and experimental data plotted along them. Plot creation process is inspired in R base graphics, with a main function creating karyoplots with no data and multiple additional functions, including custom functions written by the end-user, adding data and other graphical elements...
May 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28575169/md-task-a-software-suite-for-analyzing-molecular-dynamics-trajectories
#17
David K Brown, David L Penkler, Olivier Sheik Amamuddy, Caroline Ross, Ali Rana Atilgan, Canan Atilgan, Özlem Tastan Bishop
Summary: Molecular dynamics (MD) determines the physical motions of atoms of a biological macromolecule in a cell-like environment and is an important method in structural bioinformatics. Traditionally, measurements such as root mean square deviation, root mean square fluctuation, radius of gyration, and various energy measures have been used to analyze MD simulations. Here, we present MD-TASK, a novel software suite that employs graph theory techniques, perturbation response scanning, and dynamic cross-correlation to provide unique ways for analyzing MD trajectories...
May 31, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28569135/intervene-a-tool-for-intersection-and-visualization-of-multiple-gene-or-genomic-region-sets
#18
Aziz Khan, Anthony Mathelier
BACKGROUND: A common task for scientists relies on comparing lists of genes or genomic regions derived from high-throughput sequencing experiments. While several tools exist to intersect and visualize sets of genes, similar tools dedicated to the visualization of genomic region sets are currently limited. RESULTS: To address this gap, we have developed the Intervene tool, which provides an easy and automated interface for the effective intersection and visualization of genomic region or list sets, thus facilitating their analysis and interpretation...
May 31, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28527529/image-guided-ablation-of-renal-cell-carcinoma
#19
REVIEW
T M Wah
This review article aims to provide an overview of image-guided ablation of renal cell carcinoma (RCC) since it was first introduced in 1998. This will cover the background and rationale behind its development; an overview of the evidence for current thermal technology, such as heat-based, e.g., radiofrequency ablation (RFA), microwave ablation (MWA), and cold-based energies, e.g., cryoablation used; and summarise the published evidence regarding its treatment efficacy and oncological outcome. In addition, it aims to provide an insight into the potential role of the new non-thermal ablative technology, e...
May 17, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28523601/the-provo-corpus-a-large-eye-tracking-corpus-with-predictability-norms
#20
Steven G Luke, Kiel Christianson
This article presents the Provo Corpus, a corpus of eye-tracking data with accompanying predictability norms. The predictability norms for the Provo Corpus differ from those of other corpora. In addition to traditional cloze scores that estimate the predictability of the full orthographic form of each word, the Provo Corpus also includes measures of the predictability of the morpho-syntactic and semantic information for each word. This makes the Provo Corpus ideal for studying predictive processes in reading...
May 18, 2017: Behavior Research Methods
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