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https://www.readbyqxmd.com/read/28214993/scaleus-semantic-web-services-integration-for-biomedical-applications
#1
Pedro Sernadela, Lorena González-Castro, José Luís Oliveira
In recent years, we have witnessed an explosion of biological data resulting largely from the demands of life science research. The vast majority of these data are freely available via diverse bioinformatics platforms, including relational databases and conventional keyword search applications. This type of approach has achieved great results in the last few years, but proved to be unfeasible when information needs to be combined or shared among different and scattered sources. During recent years, many of these data distribution challenges have been solved with the adoption of semantic web...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28209129/orthograph-a-versatile-tool-for-mapping-coding-nucleotide-sequences-to-clusters-of-orthologous-genes
#2
Malte Petersen, Karen Meusemann, Alexander Donath, Daniel Dowling, Shanlin Liu, Ralph S Peters, Lars Podsiadlowski, Alexandros Vasilikopoulos, Xin Zhou, Bernhard Misof, Oliver Niehuis
BACKGROUND: Orthology characterizes genes of different organisms that arose from a single ancestral gene via speciation, in contrast to paralogy, which is assigned to genes that arose via gene duplication. An accurate orthology assignment is a crucial step for comparative genomic studies. Orthologous genes in two organisms can be identified by applying a so-called reciprocal search strategy, given that complete information of the organisms' gene repertoire is available. In many investigations, however, only a fraction of the gene content of the organisms under study is examined (e...
February 16, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28206774/cross-cultural-industrial-organizational-psychology-and-organizational-behavior-a-hundred-year-journey
#3
Michele J Gelfand, Zeynep Aycan, Miriam Erez, Kwok Leung
In celebration of the anniversary of the Journal of Applied Psychology (JAP), we take a hundred-year journey to examine how the science of cross-cultural industrial/organizational psychology and organizational behavior (CCIO/OB) has evolved, both in JAP and in the larger field. We review broad trends and provide illustrative examples in the theoretical, methodological, and analytic advances in CCIO/OB during 4 main periods: the early years (1917-1949), the middle 20th century (1950-1979), the later 20th century (1980-2000), and the 21st century (2000 to the present)...
February 16, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28186183/carbon-coated-honeycomb-ni-mn-co-o-inverse-opal-a-high-capacity-ternary-transition-metal-oxide-anode-for-li-ion-batteries
#4
David McNulty, Hugh Geaney, Colm O'Dwyer
We present the formation of a carbon-coated honeycomb ternary Ni-Mn-Co-O inverse opal as a conversion mode anode material for Li-ion battery applications. In order to obtain high capacity via conversion mode reactions, a single phase crystalline honeycombed IO structure of Ni-Mn-Co-O material was first formed. This Ni-Mn-Co-O IO converts via reversible redox reactions and Li2O formation to a 3D structured matrix assembly of nanoparticles of three (MnO, CoO and NiO) oxides, that facilitates efficient reactions with Li...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28185762/biochemical-control-and-toxicity-for-favorable-and-intermediate-risk-patients-using-real-time-intraoperative-inverse-optimization-prostate-seed-implant-less-is-more
#5
G Shukla, A Sarkar, A Hanlon, E Crockett, H C Chen, J Martelli-Raben, A Glick, B Benge, M Lobis, S Terranova, T Desperito, D Cozzolino, E Kemmerer, F Mourtada, A Raben
PURPOSE: To report the biochemical control rate and clinical outcomes with real-time inverse planning (inverse optimization prostate seed implant [IO-PSI]) for favorable-risk (FR) and intermediate-risk (IR) prostate adenocarcinoma in a community practice setting. This analysis is an extended followup of our initial report, with favorable early biochemical control rate (biochemical nonevidence of disease) of 97% at 4 years. METHODS AND MATERIALS: Three hundred fifty-seven evaluable patients with FR and IR prostate cancer underwent real-time IO-PSI (iodine-125/145 Gy or palladium-103/120 Gy) between 2001 and 2013...
February 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28185405/evaluation-of-long-term-combination-therapy-with-peritoneal-dialysis-and-hemodialysis
#6
Reo Kanda, Hiroaki Io, Junichiro Nakata, Yuko Makita, Yu Sasaki, Mayumi Matsumoto, Keiichi Wakabayashi, Yasuhiko Tomino, Yusuke Suzuki
It is well known that a combination therapy with peritoneal dialysis (PD) and hemodialysis (HD) is feasible and may improve clinical status in patients for whom adequate solute and fluid removal is difficult to achieve with PD alone. The objective of the present study was to evaluate whether the therapy is useful in the likelihood of long-term peritoneal membrane and cardiac function. The therapy was 6 days of PD and one session of HD per week. Physical, biochemical, dialysate-to-plasma ratio of creatinine (D/P Cr), arteriovenous fistula (AVF) blood flow, and left ventricular mass index (LVMI) data were prospectively analyzed in 30 patients with measurements performed at 0 and 6 months, and for 21 patients, 12 or 18 months after initiation of the therapy...
February 10, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28174599/deapp-an-interactive-web-interface-for-differential-expression-analysis-of-next-generation-sequence-data
#7
Yan Li, Jorge Andrade
BACKGROUND: A growing trend in the biomedical community is the use of Next Generation Sequencing (NGS) technologies in genomics research. The complexity of downstream differential expression (DE) analysis is however still challenging, as it requires sufficient computer programing and command-line knowledge. Furthermore, researchers often need to evaluate and visualize interactively the effect of using differential statistical and error models, assess the impact of selecting different parameters and cutoffs, and finally explore the overlapping consensus of cross-validated results obtained with different methods...
2017: Source Code for Biology and Medicine
https://www.readbyqxmd.com/read/28167257/tetradecanol-reduces-el-4-t-cell-growth-by-the-down-regulation-of-nf-%C3%AE%C2%BAb-mediated-il-2-secretion
#8
Jung Up Park, Bok Yun Kang, Hwa-Jeong Lee, Sunoh Kim, Donghyuck Bae, Jong-Hwan Park, Young Ran Kim
Tetradecanol is a straight-chain saturated fatty alcohol purified from Dendropanax morbifera leaves. We found that tetradecanol (30μM) reduced specifically the growth of T cells such as EL-4 T cell and isolated murine CD4(+) T cells. In this study, we investigated the effects of tetradecanol on the regulation of interlukin-2 (IL-2), a potent T cell growth factor. Tetradecanol significantly inhibited IL-2 secretion in EL-4 T cells activated with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (Io) and also in isolated murine CD4(+) T cells activated with anti-CD3 and anti-CD28 antibodies...
February 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28161626/turning-hydrophilic-bacteria-into-biorenewable-hydrophobic-material-with-potential-antimicrobial-activity-via-interaction-with-chitosan
#9
Orakan Hanpanich, Pravit Wongkongkatep, Thunyarat Pongtharangkul, Jirarut Wongkongkatep
Alteration of a bacteriocin-producing hydrophilic bacterium, Lactococcus lactis IO-1, into a hydrophobic material with potential antimicrobial activity using chitosan was investigated and compared with five other bacterial species with industrial importance. The negatively charged bacterial cells were neutralized by positively charged chitosan, resulting in a significant increase in the hydrophobicity of the bacterial cell surface. The largest Gram-positive B. megaterium ATCC 14581 showed a moderate response to chitosan while the smaller E...
January 27, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28156520/the-i-one-trial-integrative-oncology-education-for-patient-navigators-a-randomized-pilot-trial-of-web-based-distance-learning-with-or-without-small-group-retreat
#10
Karen Beard, Yuan Liu, Alice S Kerber
: 171 Background: One of the major barriers to implementation of an integrative oncology (IO) approach is appropriately trained providers. This trial investigated the effectiveness of a mixed method educational program versus web based learning only for oncology patient navigators relative to knowledge and application of IO modalities. METHODS: Patient navigators were randomized 1:1 to Web based education only (WEB) vs. WEB plus residential retreat (WEB+R). The trial was conducted as a randomized, two-group, pre-test/post-test design with 4 repeated measures...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156437/integrative-oncology-consultation-and-symptom-palliation-analysis-of-patient-reported-outcomes-at-a-comprehensive-cancer-center
#11
Jennifer Leigh McQuade, Richard T Lee, Jane Williams, Amy Spelman, Bryan Fellman, Yisheng Li, Eduardo Bruera, Lorenzo Cohen
: 84 Background: Patients (pts) receiving cancer care are increasingly interested in complementary health approaches to improve symptoms and quality of life. We report on demographics and patient reported outcomes in an integrative oncology (IO) clinic. METHODS: Pts presenting for IO consultation or follow-up completed: Measure Yourself Concerns and Wellbeing (MYCaW), Edmonton Symptom Assessment Scale (ESAS), Short Form 12 (SF-12) quality of life (QOL) scale, and an overall satisfaction questionnaire...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152809/patient-support-call-center-interaction-with-the-oncology-clinic
#12
Melissa Jameson, Kathryn Eagye, Mitra Abdullahpour, Michael A Kolodziej, Maria Sipala, Amy Supraner, J Russell Hoverman
: 84 Background: Cancer patients receiving chemotherapy can become ill, often leading to hospitalization, adding huge costs to care. This is especially true with older cancer patients. Innovent Oncology (IO), an oncology disease management program, and Texas Oncology (TO) are conducting a novel program, funded by Aetna. Patients who begin IV chemotherapy are called by an IO nurse, working remotely, but with access to TO's Electronic Medical Record. If the call center nurse detects a concern she notifies the practice...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149326/genome-wide-methylation-data-mirror-ancestry-information
#13
Elior Rahmani, Liat Shenhav, Regev Schweiger, Paul Yousefi, Karen Huen, Brenda Eskenazi, Celeste Eng, Scott Huntsman, Donglei Hu, Joshua Galanter, Sam S Oh, Melanie Waldenberger, Konstantin Strauch, Harald Grallert, Thomas Meitinger, Christian Gieger, Nina Holland, Esteban G Burchard, Noah Zaitlen, Eran Halperin
BACKGROUND: Genetic data are known to harbor information about human demographics, and genotyping data are commonly used for capturing ancestry information by leveraging genome-wide differences between populations. In contrast, it is not clear to what extent population structure is captured by whole-genome DNA methylation data. RESULTS: We demonstrate, using three large-cohort 450K methylation array data sets, that ancestry information signal is mirrored in genome-wide DNA methylation data and that it can be further isolated more effectively by leveraging the correlation structure of CpGs with cis-located SNPs...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28147710/preparation-of-iron-oxide-nanoparticles-decorated-carbon-nanotube-using-laser-ablation-in-liquid-and-their-antimicrobial-activity
#14
Khawla S Khashan, Ghassan M Sulaiman, Rafal Mahdi
The antimicrobial activity was investigated for iron oxide IO nanoparticles (NPs)-decorated carbon nanotubes CNT prepared successfully by Nd:YAG-pulsed laser ablation in the liquid process. TEM reveals the composite NP and exhibits semispherical of iron oxide NPs, which aggregate around rolled and unrolled graphene sheet. XRD pattern proved the presence of carbon and different phases of IO NPs. Then, the antibacterial activity of the NPs was examined against different bacteria using nutrient broth and nutrient agar methods, which was enhanced using IO...
February 1, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28141954/successful-management-of-intraoperative-haemorrhage-during-emergency-cervical-cerclage-using-balloon-tamponade
#15
Shota Kanbayashi, Eiji Kondoh, Koh Suginami, Shingo Io, Junzo Hamanishi, Ikuo Konishi
No abstract text is available yet for this article.
January 31, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28141874/metabox-a-toolbox-for-metabolomic-data-analysis-interpretation-and-integrative-exploration
#16
Kwanjeera Wanichthanarak, Sili Fan, Dmitry Grapov, Dinesh Kumar Barupal, Oliver Fiehn
Similar to genomic and proteomic platforms, metabolomic data acquisition and analysis is becoming a routine approach for investigating biological systems. However, computational approaches for metabolomic data analysis and integration are still maturing. Metabox is a bioinformatics toolbox for deep phenotyping analytics that combines data processing, statistical analysis, functional analysis and integrative exploration of metabolomic data within proteomic and transcriptomic contexts. With the number of options provided in each analysis module, it also supports data analysis of other 'omic' families...
2017: PloS One
https://www.readbyqxmd.com/read/28140443/onset-and-duration-of-intravenous-and-intraosseous-rocuronium-in-hypovolemic-swine
#17
Miguel Nemeth, George N Williams, Debbie Prichard, Angie McConnico, Don Johnson, Michael Loughren
OBJECTIVE: Compare the onset and duration of rocuronium administered via the intravenous (IV), and intraosseous (IO) routes in a hypovolemic swine model. DESIGN: Prospective, between subjects, experimental study. SETTING: Vivarium. SUBJECTS: Yorkshire-cross swine (N = 8). INTERVENTION: Electromyography (EMG) amplitudes were recorded at baseline and for every 15 seconds after administering 1.2 mg/kg of rocuronium via IV or IO routes to hypovolemic swine...
October 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28140438/the-comparison-of-humeral-intraosseous-and-intravenous-administration-of-vasopressin-on-return-of-spontaneous-circulation-and-pharmacokinetics-in-a-hypovolemic-cardiac-arrest-swine-model
#18
Mark H Wimmer, Kenneth Heffner, Michael Smithers, Richard Culley, Jennifer Coyner, Michael Loughren, Don Johnson
INTRODUCTION: The American Heart Association (AHA) recommends intravenous (IV) or intraosseous (IO) vasopressin in Advanced Cardiac Life Support (ACLS). Obtaining IV access in hypovolemic cardiac arrest patients can be difficult, and IO access is often obtained in these life threatening situations. No studies have been conducted to determine the effects of humeral IO (HIO) access with vasopressin in the return of spontaneous circulation (ROSC). Our study compared the kinetics of vasopressin and ROSC with HIO with IV access in the hypovolemic swine model...
October 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28140437/pharmacokinetics-of-sternal-intraossesous-atropine-administration-in-normovolemic-and-hypovolemic-swine
#19
Mark Cornell, Jaime Kelbaugh, Brian Todd, Krista Christianson, Kevin Grayson, Joseph O'Sullivan, Don Johnson, Michael Loughren
OBJECTIVE: Characterize and compare the pharmacokinetics of atropine administered via the sternal intraosseous (IO) route in a normovolemic and hypovolemic swine model. DESIGN: Prospective, experimental study. SETTING: Vivarium. SUBJECTS: Yorkshire-cross swine (N = 12). INTERVENTION: Atropine was administered via the sternal IO route to normovolemic and hypovolemic swine. Blood samples were drawn at regular intervals after atropine administration and analyzed for plasma atropine concentration...
October 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28140436/en-route-intraosseous-access-performed-in-the-combat-setting
#20
Shelia Savell, Alejandra G Mora, Crystal A Perez, Vikhyat S Bebarta, Maj Joseph K Maddry
OBJECTIVE: To describe and compare vascular access practices used by en route care providers during medical evacuation (MEDEVAC). DESIGN: This was a retrospective cohort study. Medical records of US military personnel injured in combat and transported by MEDEVAC teams were queried. PATIENTS: The subjects were transported by military en route care providers, in the combat theater during Operation Enduring Freedom (OEF) between January 2011 and March 2014...
October 2016: American Journal of Disaster Medicine
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