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https://www.readbyqxmd.com/read/27931322/interstrain-differences-in-co2-induced-pulmonary-hemorrhage-in-mice
#1
Suhrim Fisher, Winona L Burgess, Kenneth D Hines, Gary L Mason, James R Owiny
Carbon dioxide is the most commonly used gas for euthanasia of rodents. The current AVMA Guidelines recommend slowly filling the container with CO2 (SF) and now indicate that the practice of placing conscious animals in containers prefilled with CO2 (PF) is unacceptable. An investigator noted pulmonary hemorrhage (PH) in BALB/c mice euthanized by SF that was not observed after PF. Here we evaluated whether the air-displacement rate (SF compared with PF) influenced the development of PH or nasal hemorrhage (NH) in 2 commonly used mouse strains...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27923273/decision-points-in-the-treatment-of-transfusional-iron-overload-in-patients-with-myelodysplastic-syndromes-why-when-and-how-to-chelate
#2
Farhan Imran, Pradyumna Phatak
Patients with myelodysplastic syndromes (MDS) differ from those with other transfusion-dependent conditions (eg, thalassemia) as they are typically older, have comorbid conditions, and a generally shorter life expectancy. The underlying disease process in MDS and frequent use of red blood cell transfusions lead to iron accumulation and ultimately organ damage. Whether iron-reducing interventions such as chelation therapy can improve outcomes in this population is currently under investigation. Areas Covered: We reviewed published English-language articles from PubMed on the topic of iron overload (IO) in MDS, and the use of iron chelation therapies (ICTs) to alleviate iron burden...
December 7, 2016: Expert Review of Hematology
https://www.readbyqxmd.com/read/27918573/benchmarking-the-cost-per-person-of-mass-treatment-for-selected-neglected-tropical-diseases-an-approach-based-on-literature-review-and-meta-regression-with-web-based-software-application
#3
Christopher Fitzpatrick, Fiona M Fleming, Matthew Madin-Warburton, Timm Schneider, Filip Meheus, Kingsley Asiedu, Anthony W Solomon, Antonio Montresor, Gautam Biswas
BACKGROUND: Advocacy around mass treatment for the elimination of selected Neglected Tropical Diseases (NTDs) has typically put the cost per person treated at less than US$ 0.50. Whilst useful for advocacy, the focus on a single number misrepresents the complexity of delivering "free" donated medicines to about a billion people across the world. We perform a literature review and meta-regression of the cost per person per round of mass treatment against NTDs. We develop a web-based software application (https://healthy...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27905880/the-lair-a-resource-for-exploratory-analysis-of-published-rna-seq-data
#4
Harold Pimentel, Pascal Sturmfels, Nicolas Bray, Páll Melsted, Lior Pachter
Increased emphasis on reproducibility of published research in the last few years has led to the large-scale archiving of sequencing data. While this data can, in theory, be used to reproduce results in papers, it is difficult to use in practice. We introduce a series of tools for processing and analyzing RNA-Seq data in the Sequence Read Archive, that together have allowed us to build an easily extendable resource for analysis of data underlying published papers. Our system makes the exploration of data easily accessible and usable without technical expertise...
December 1, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27896026/jicbioimage-a-tool-for-automated-and-reproducible-bioimage-analysis
#5
Tjelvar S G Olsson, Matthew Hartley
There has been steady improvement in methods for capturing bioimages. However analysing these images still remains a challenge. The Python programming language provides a powerful and flexible environment for scientific computation. It has a wide range of supporting libraries for image processing but lacks native support for common bioimage formats, and requires specific code to be written to ensure that suitable audit trails are generated and analyses are reproducible. Here we describe the development of a Python tool that: (1) allows users to quickly view and explore microscopy data; (2) generate reproducible analyses, encoding a complete history of image transformations from raw data to final result; and (3) scale up analyses from initial exploration to high throughput processing pipelines, with a minimal amount of extra effort...
2016: PeerJ
https://www.readbyqxmd.com/read/27895718/consensus-diversity-plots-a-global-diversity-analysis-of-chemical-libraries
#6
Mariana González-Medina, Fernando D Prieto-Martínez, John R Owen, José L Medina-Franco
BACKGROUND: Measuring the structural diversity of compound databases is relevant in drug discovery and many other areas of chemistry. Since molecular diversity depends on molecular representation, comprehensive chemoinformatic analysis of the diversity of libraries uses multiple criteria. For instance, the diversity of the molecular libraries is typically evaluated employing molecular scaffolds, structural fingerprints, and physicochemical properties. However, the assessment with each criterion is analyzed independently and it is not straightforward to provide an evaluation of the "global diversity"...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27890546/radiological-evaluation-of-sphenozygomatic-suture-fixation-for-restoration-of-orbital-volume-a-retrospective-study
#7
Rohit Sharma, Chiyyarath Gopalan Muralidharan, Indranil Deb Roy, Narendra Kumar Jain, Seema Patrikar
PURPOSE: Lateral displacement of fracture zygomaticomaxillary complex (ZMC) can cause significant increase in orbital volume leading to enophthalmos. The aim of this study was to radiologically evaluate the efficacy of sphenozygomatic (SZ) suture fixation for restoration of orbital volume after elevation of the temporalis in cases of fracture ZMC where the fixation of zygomatic arch (ZA) was deemed necessary through latero-posterior approach. MATERIALS & METHODS: 43 operated cases of fracture ZMC using 4-point fixation were divided into two groups...
October 20, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27886146/a-robot-based-tool-for-physical-and-cognitive-rehabilitation-of-elderly-people-using-biofeedback
#8
Leire Lopez-Samaniego, Begonya Garcia-Zapirain
This publication presents a complete description of a technological solution system for the physical and cognitive rehabilitation of elderly people through a biofeedback system, which is combined with a Lego robot. The technology used was the iOS's (iPhone Operating System) Objective-C programming language and its XCode programming environment; and SQLite in order to create the database. The biofeedback system is implemented by the use of two biosensors which are, in fact, a Microsoft band 2 in order to register the user's heart rate and a MYO sensor to detect the user's arm movement...
November 24, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27882356/intra-osseous-co-transplantation-of-cd34-selected-umbilical-cord-blood-and-mesenchymal-stromal-cells
#9
Leland Metheny, Saada Eid, Karen Lingas, Jane Reese, Howard Meyerson, Alexander Tong, Marcos de Lima, Alex Y Huang
Human mesenchymal stromal cells (MSC) have been shown to support the growth and differentiation of hematopoietic stem cells (HSC). We hypothesized that intra-osseous (IO) co-transplantation of MSC and umbilical cord blood (UCB) may be effective in improving early HSC engraftment, as IO transplantation has been demonstrated to enhance UCB engraftment in NOD SCID-gamma (NSG) mice. Following non-lethal irradiation (300rads), 6 groups of NSG mice were studied: 1) intravenous (IV) UCB CD34(+) cells, 2) IV UCB CD34(+) cells and MSC, 3) IO UCB CD34(+) cells, 4) IO UCB CD34(+) cells and IO MSC, 5) IO UCB CD34(+) cells and IV MSC, and 6) IV UCB CD34(+) and IO MSC...
2016: Hematol Med Oncol
https://www.readbyqxmd.com/read/27881829/biomechanical-comparison-of-fixation-devices-for-first-metatarsocuneiform-joint-arthrodesis
#10
Ashleen R Knutsen, John F Fleming, Edward Ebramzadeh, Nathan C Ho, Tibor Warganich, Thomas G Harris, Sophia N Sangiorgio
: Common surgical treatment of first tarsal-metatarsal arthritis is by first metatarsocuneiform joint arthrodesis. While crossed-screw and locking plate fixation are the most widely used methods, a novel construct was designed to alleviate soft tissue irritation while still providing stable fixation. Using anatomic first metatarsal and medial cuneiform composites, we compared 3 arthrodesis implants (crossed-screw, dorsal locking plate, and IO Fix) under 2 cyclic bending loading scenarios (cantilever and 4-point bending)...
November 23, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27875984/plastid-nucleotide-resolution-analysis-of-next-generation-sequencing-and-genomics-data
#11
Joshua G Dunn, Jonathan S Weissman
BACKGROUND: Next-generation sequencing (NGS) informs many biological questions with unprecedented depth and nucleotide resolution. These assays have created a need for analytical tools that enable users to manipulate data nucleotide-by-nucleotide robustly and easily. Furthermore, because many NGS assays encode information jointly within multiple properties of read alignments - for example, in ribosome profiling, the locations of ribosomes are jointly encoded in alignment coordinates and length - analytical tools are often required to extract the biological meaning from the alignments before analysis...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27875172/booc-io-an-education-system-with-hierarchical-concept-maps-and-dynamic-non-linear-learning-plans
#12
Michail Schwab, Hendrik Strobelt, James Tompkin, Colin Fredericks, Connor Huff, Dana Higgins, Anton Strezhnev, Mayya Komisarchik, Gary King, Hanspeter Pfister
Information hierarchies are difficult to express when real-world space or time constraints force traversing the hierarchy in linear presentations, such as in educational books and classroom courses. We present booc.io, which allows linear and non-linear presentation and navigation of educational concepts and material. To support a breadth of material for each concept, booc.io is Web based, which allows adding material such as lecture slides, book chapters, videos, and LTIs. A visual interface assists the creation of the needed hierarchical structures...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27871384/protein-based-inverse-opals-a-novel-support-for-enzyme-immobilization
#13
Yanjun Jiang, Wenya Sun, Yaping Wang, Lihui Wang, Liya Zhou, Jing Gao, Ying He, Li Ma, Xu Zhang
In this study, protein-based inverse opals were prepared for the first time by using the colloidal crystal templating method. The preparation process involved three steps including filling the templates with protein molecules, crosslinking, and template removal. The obtained inverse opals were used to immobilize Penicillin G acylase (PGA) because of its intrinsic biocompatible property. The immobilization process was optimized and the properties of the immobilized PGA (PGA@IO) were investigated. PGA@IO exhibited improved thermal and pH stability compared with its free counterpart...
January 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27870553/comparison-of-two-intraosseous-devices-the-nio-versus-the-ez-io-by-novice-users-a-randomized-cross-over-trial
#14
Avi Shina, Erez Nissim Baruch, Amir Shlaifer, Ami Shovali, Moran Levi, Or Yosefy, David Segal, Tarif Bader, Itai Shavit, Avraham Yitzhak
BACKGROUND: During resuscitation in the field, intraosseous (IO) access may be achieved using a variety of available devices, often attempted by inexperienced users. AIM: We sought to examine the success rate and ease-of-use ratings of an IO device, the NIO® (New Intraosseous Persys Medical, Houston, TX, USA) in comparison to the Arrow® EZ-IO® (Teleflex Medical Research Triangle Park, NC, USA) by novice users. METHODS: We performed a randomized crossover trial...
November 21, 2016: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27869815/taco-produces-robust-multisample-transcriptome-assemblies-from-rna-seq
#15
Yashar S Niknafs, Balaji Pandian, Hariharan K Iyer, Arul M Chinnaiyan, Matthew K Iyer
Accurate transcript structure and abundance inference from RNA sequencing (RNA-seq) data is foundational for molecular discovery. Here we present TACO, a computational method to reconstruct a consensus transcriptome from multiple RNA-seq data sets. TACO employs novel change-point detection to demarcate transcript start and end sites, leading to improved reconstruction accuracy compared with other tools in its class. The tool is available at http://tacorna.github.io and can be readily incorporated into RNA-seq analysis workflows...
November 21, 2016: Nature Methods
https://www.readbyqxmd.com/read/27869455/an-interference-model-of-visual-working-memory
#16
Klaus Oberauer, Hsuan-Yu Lin
The article introduces an interference model of working memory for information in a continuous similarity space, such as the features of visual objects. The model incorporates the following assumptions: (a) Probability of retrieval is determined by the relative activation of each retrieval candidate at the time of retrieval; (b) activation comes from 3 sources in memory: cue-based retrieval using context cues, context-independent memory for relevant contents, and noise; (c) 1 memory object and its context can be held in the focus of attention, where it is represented with higher precision, and partly shielded against interference...
November 21, 2016: Psychological Review
https://www.readbyqxmd.com/read/27867794/the-impact-of-an-icme-on-the-jovian-x-ray-aurora
#17
William R Dunn, Graziella Branduardi-Raymont, Ronald F Elsner, Marissa F Vogt, Laurent Lamy, Peter G Ford, Andrew J Coates, G Randall Gladstone, Caitriona M Jackman, Jonathan D Nichols, I Jonathan Rae, Ali Varsani, Tomoki Kimura, Kenneth C Hansen, Jamie M Jasinski
We report the first Jupiter X-ray observations planned to coincide with an interplanetary coronal mass ejection (ICME). At the predicted ICME arrival time, we observed a factor of ∼8 enhancement in Jupiter's X-ray aurora. Within 1.5 h of this enhancement, intense bursts of non-Io decametric radio emission occurred. Spatial, spectral, and temporal characteristics also varied between ICME arrival and another X-ray observation two days later. Gladstone et al. (2002) discovered the polar X-ray hot spot and found it pulsed with 45 min quasiperiodicity...
March 2016: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/27865421/cannabidiol-cbd-induces-functional-tregs-in-response-to-low-level-t-cell-activation
#18
Saphala Dhital, John V Stokes, Nogi Park, Keun Seok Seo, Barbara L F Kaplan
Many effects of the non-psychoactive cannabinoid, cannabidiol (CBD), have been described in immune responses induced by strong immunological stimuli. It has also been shown that CBD enhances IL-2 production in response to low-level T cell stimulation. Since IL-2, in combination with TGF-β1, are critical for Treg induction, we hypothesized that CBD would induce CD4(+)CD25(+)FOXP3(+) Tregs in response to low-level stimulation. Low-level T cell stimulation conditions were established based on minimal CD25 expression in CD4(+) cells using suboptimal PMA/Io (4nM/0...
November 9, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27863334/modulation-of-the-cytokine-profile-in-caco-2-cells-by-faecal-lactobacilli-and-bifidobacteria-from-individuals-with-distinct-dietary-habits
#19
Diomira Luongo, Annachiara Coppola, Lucia Treppiccione, Paolo Bergamo, Alida Sorrentino, Ilario Ferrocino, Silvia Turroni, Erasmo Neviani, Raffaella Di Cagno, Luca Cocolin, Mauro Rossi
Enterocytes are actively involved in the defense against pathogens and they limit penetration of commensal microbes into tissues. They also have an important role in gut immunity as enterocytes confer mucosal dendritic cell specialisation. On the other hand, the microbiota is directly involved in the development and modulation of the intestinal immune system. Particularly, lactobacilli and bifidobacteria play a primary role in shaping the immune response. We further explored this issue by evaluating whether functional differences in Caco-2 cells could characterise faecal populations of lactobacilli (155 samples) and bifidobacteria (110 samples) isolated from three dietary cohorts (omnivores, ovo-lacto-vegetarians and vegans) recruited at four Italian centres (Turin, Parma, Bologna and Bari)...
November 15, 2016: Cytokine
https://www.readbyqxmd.com/read/27862743/tuning-of-silver-catalyst-mesostructure-promotes-selective-carbon-dioxide-conversion-into-fuels
#20
Youngmin Yoon, Anthony Shoji Hall, Yogesh Surendranath
An electrode's performance for catalytic CO2 conversion to fuels is a complex convolution of surface structure and transport effects. Using well-defined mesostructured silver inverse opal (Ag-IO) electrodes, it is demonstrated that mesostructure-induced transport limitations alone serve to increase the turnover frequency for CO2 activation per unit area, while simultaneously improving reaction selectivity. The specific activity for catalyzed CO evolution systematically rises by three-fold and the specific activity for catalyzed H2 evolution systematically declines by ten-fold with increasing mesostructural roughness of Ag-IOs...
November 10, 2016: Angewandte Chemie
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