keyword
MENU ▼
Read by QxMD icon Read
search

IO

keyword
https://www.readbyqxmd.com/read/28102532/time-to-epinephrine-in-out-of-hospital-cardiac-arrest-a-retrospective-analysis-of-intraosseous-versus-intravenous-access
#1
Elliot M Ross, Julian Mapp, Chetan Kharod, David A Wampler, Christopher Velasquez, David A Miramontes
INTRODUCTION: The 2015 advanced cardiac life support update continues to advocate administering epinephrine during cardiac arrest. The goal of our study is to determine if prehospital intraosseous (IO) access results in shorter time to epinephrine than prehospital peripheral intravenous (PIV) access. METHODS: The out-of-hospital cardiac arrest (OHCA) database of a large, urban, fire-based emergency medical services system was searched for consecutive cases of OHCA between January 2013 and December 2015...
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28097056/rhea-a-transparent-and-modular-r-pipeline-for-microbial-profiling-based-on-16s-rrna-gene-amplicons
#2
Ilias Lagkouvardos, Sandra Fischer, Neeraj Kumar, Thomas Clavel
The importance of 16S rRNA gene amplicon profiles for understanding the influence of microbes in a variety of environments coupled with the steep reduction in sequencing costs led to a surge of microbial sequencing projects. The expanding crowd of scientists and clinicians wanting to make use of sequencing datasets can choose among a range of multipurpose software platforms, the use of which can be intimidating for non-expert users. Among available pipeline options for high-throughput 16S rRNA gene analysis, the R programming language and software environment for statistical computing stands out for its power and increased flexibility, and the possibility to adhere to most recent best practices and to adjust to individual project needs...
2017: PeerJ
https://www.readbyqxmd.com/read/28093405/distributedfba-jl-high-level-high-performance-flux-balance-analysis-in-julia
#3
Laurent Heirendt, Ines Thiele, Ronan M T Fleming
MOTIVATION: Flux balance analysis, and its variants, are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations. RESULTS: DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on a subset or all the reactions of large and huge-scale networks, on any number of threads or nodes...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28090199/mastr-ms-a-web-based-collaborative-laboratory-information-management-system-lims-for-metabolomics
#4
Adam Hunter, Saravanan Dayalan, David De Souza, Brad Power, Rodney Lorrimar, Tamas Szabo, Thu Nguyen, Sean O'Callaghan, Jeremy Hack, James Pyke, Amsha Nahid, Roberto Barrero, Ute Roessner, Vladimir Likic, Dedreia Tull, Antony Bacic, Malcolm McConville, Matthew Bellgard
BACKGROUND: An increasing number of research laboratories and core analytical facilities around the world are developing high throughput metabolomic analytical and data processing pipelines that are capable of handling hundreds to thousands of individual samples per year, often over multiple projects, collaborations and sample types. At present, there are no Laboratory Information Management Systems (LIMS) that are specifically tailored for metabolomics laboratories that are capable of tracking samples and associated metadata from the beginning to the end of an experiment, including data processing and archiving, and which are also suitable for use in large institutional core facilities or multi-laboratory consortia as well as single laboratory environments...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28088762/the-super-n-motifs-model-a-novel-alignment-free-approach-for-representing-and-comparing-rna-secondary-structures
#5
Jean-Pierre Séhi Glouzon, Jean-Pierre Perreault, Shengrui Wang
MOTIVATION: Comparing ribonucleic acid (RNA) secondary structures of arbitrary size uncovers structural patterns that can provide a better understanding of RNA functions. However, performing fast and accurate secondary structure comparisons is challenging when we take into account the RNA configuration (i.e. linear or circular), the presence of pseudoknot and G-quadruplex (G4) motifs and the increasing number of secondary structures generated by high-throughput probing techniques. To address this challenge, we propose the super-n-motifs model based on a latent analysis of enhanced motifs comprising not only basic motifs but also adjacency relations...
January 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28078397/optimized-synthesis-of-novel-prenyl-ferulate-performed-by-feruloyl-esterases-from-myceliophthora-thermophila-in-microemulsions
#6
Io Antonopoulou, Laura Leonov, Peter Jütten, Gabriella Cerullo, Vincenza Faraco, Adamantia Papadopoulou, Dimitris Kletsas, Marianna Ralli, Ulrika Rova, Paul Christakopoulos
Five feruloyl esterases (FAEs; EC 3.1.1.73), FaeA1, FaeA2, FaeB1, and FaeB2 from Myceliophthora thermophila C1 and MtFae1a from M. thermophila ATCC 42464, were tested for their ability to catalyze the transesterification of vinyl ferulate (VFA) with prenol in detergentless microemulsions. Reaction conditions were optimized investigating parameters such as the medium composition, the substrate concentration, the enzyme load, the pH, the temperature, and agitation. FaeB2 offered the highest transesterification yield (71...
January 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28069593/knime4ngs-a-comprehensive-toolbox-for-next
#7
Maximilian Hastreiter, Tim Jeske, Jonathan Hoser, Michael Kluge, Kaarin Ahomaa, Marie-Sophie Friedl, Sebastian J Kopetzky, Jan-Dominik Quell, H- Werner Mewes, Robert Küffner
: Analysis of Next Generation Sequencing (NGS) data requires the processing of large datasets by chaining various tools with complex input and output formats. In order to automate data analysis, we propose to standardize NGS tasks into modular workflows. This simplifies reliable handling and processing of NGS data, and corresponding solutions become substantially more reproducible and easier to maintain. Here, we present a documented, linux-based, toolbox of 42 processing modules that are combined to construct workflows facilitating a variety of tasks such as DNAseq and RNAseq analysis...
January 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28061810/pyviko-an-automated-python-tool-to-design-gene-knockouts-in-complex-viruses-with-overlapping-genes
#8
Louis J Taylor, Klaus Strebel
BACKGROUND: Gene knockouts are a common tool used to study gene function in various organisms. However, designing gene knockouts is complicated in viruses, which frequently contain sequences that code for multiple overlapping genes. Designing mutants that can be traced by the creation of new or elimination of existing restriction sites further compounds the difficulty in experimental design of knockouts of overlapping genes. While software is available to rapidly identify restriction sites in a given nucleotide sequence, no existing software addresses experimental design of mutations involving multiple overlapping amino acid sequences in generating gene knockouts...
January 7, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28056760/mpd-multiplex-primer-design-for-next-generation-targeted-sequencing
#9
Thomas S Wingo, Alex Kotlar, David J Cutler
BACKGROUND: Targeted resequencing offers a cost-effective alternative to whole-genome and whole-exome sequencing when investigating regions known to be associated with a trait or disease. There are a number of approaches to targeted resequencing, including microfluidic PCR amplification, which may be enhanced by multiplex PCR. Currently, there is no open-source software that can design next-generation multiplex PCR experiments that ensures primers are unique at a genome-level and efficiently pools compatible primers...
January 5, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28018682/bent-metal-in-a-bone-a-rare-complication-of-an-emergent-procedure-or-a-deficiency-in-skill-set
#10
Mridula Krishnan, Katherine Lester, Amber Johnson, Kaye Bardeloza, Peter Edemekong, Ilya Berim
Intraosseous (IO) access is an important consideration in patients with difficult intravenous (IV) access in emergent situations. IO access in adults has become more popular due to the ease of placement and high success rates. The most common sites of access include the proximal tibia and the humeral head. The complications associated are rare but can be catastrophic: subsequent amputation of a limb has been described in the literature. We report a 25-year-old female presenting with diabetic ketoacidosis (DKA) in whom emergent IO access was complicated by needle bending inside the humerus...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28018670/inferior-oblique-weakening-and-abnormal-head-position-controlled-myotomy-versus-recession
#11
R Migliorini, R Malagola, A M Comberiati, L Arrico
Purpose. Randomized controlled trial aimed at comparing surgical outcomes in a group of patients suffering from hyperfunction of the inferior oblique (IO) muscle with abnormal head position (AHP). The surgical techniques being compared are Recession and (thread) Controlled Myotomy. Materials and Methods. The group of 20 patients suffering from medium-high hyperfunction of the IO was assessed through an ophthalmological and orthoptic examination. 10 patients underwent traditional Recession (Group  A) and 10 were treated with Controlled Myotomy (Group  B)...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28018427/successful-nonoperative-management-of-high-grade-blunt-renal-injuries
#12
Allison M May, Oussama Darwish, Brian Dang, John J Monda, Prajakta Adsul, Johar Syed, Sameer A Siddiqui
Current management of high-grade blunt renal trauma favors a nonoperative approach when possible. We performed a retrospective study of high grade blunt renal injuries at our level I trauma center to determine the indications and success of nonoperative management (NOM). 47 patients with blunt grade IV or V injuries were identified between October 2004 and December 2013. Immediate operative patients (IO) were compared to nonoperatively managed (NOM). Of the 47 patients, 3 (6.4%) were IO and 44 (95.6%) NOM. IO patients had a higher heart rate on admission, 133 versus 100 in NOM (P = 0...
2016: Advances in Urology
https://www.readbyqxmd.com/read/28012017/surgical-exploration-in-persistent-inferior-oblique-overactions
#13
Feray Koc
PURPOSE: To report the causes of persistent inferior oblique (IO) overactions after disinsertion procedure. METHODS: Surgical findings of nine eyes of eight patients who needed secondary surgery to the IO muscles because of persistent overaction after IO disinsertion were evaluated retrospectively. Inferior obliques were found partially retracted into their sheath, and some parts of the proximal muscle stumps were found to have established attachments through scar tissues to the sclera in five eyes...
December 24, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/28011779/cerebroviz-an-r-package-for-anatomical-visu-alization-of-spatiotemporal-brain-data
#14
Ethan Bahl, Tanner Koomar, Jacob J Michaelson
: Spatiotemporal transcriptomic profiling has provided valuable insight into the patterning of gene expression throughout the human brain from early fetal development to adulthood. When combined with prior knowledge of a disease's age at onset and region-specificity, these expression profiles have provided the necessary context to both strengthen putative gene-disease associations and infer new associations. While a wealth of spatiotemporal expression data exists, there are currently no tools available to visualize this data within the anatomical context of the brain, thus limiting the intuitive interpretation of many such findings...
December 22, 2016: Bioinformatics
https://www.readbyqxmd.com/read/28009818/semantic-agent-based-service-middleware-and-simulation-for-smart-cities
#15
Ming Liu, Yang Xu, Haixiao Hu, Abdul-Wahid Mohammed
With the development of Machine-to-Machine (M2M) technology, a variety of embedded and mobile devices is integrated to interact via the platform of the Internet of Things, especially in the domain of smart cities. One of the primary challenges is that selecting the appropriate services or service combination for upper layer applications is hard, which is due to the absence of a unified semantical service description pattern, as well as the service selection mechanism. In this paper, we define a semantic service representation model from four key properties: Capability (C), Deployment (D), Resource (R) and IOData (IO)...
December 21, 2016: Sensors
https://www.readbyqxmd.com/read/28009009/bacteriophage-t5-gene-d10-encodes-a-branch-migration-protein
#16
Io Nam Wong, Jon R Sayers, Cyril M Sanders
Helicases catalyze the unwinding of double-stranded nucleic acids where structure and phosphate backbone contacts, rather than nucleobase sequence, usually determines substrate specificity. We have expressed and purified a putative helicase encoded by the D10 gene of bacteriophage T5. Here we report that this hitherto uncharacterized protein possesses branch migration and DNA unwinding activity. The initiation of substrate unwinding showed some sequence dependency, while DNA binding and DNA-dependent ATPase activity did not...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28008762/a-scalable-synthesis-of-honeycomb-like-ordered-mesoporous-carbon-nanosheets-and-their-application-in-lithium-sulfur-batteries
#17
Seung-Keun Park, Jeongyeon Lee, Taejin Hwang, Byungchul Jang, Yuanzhe Piao
There is a growing need to improve the electrical conductivity of the cathode and to suppress the rapid capacity decay during cycling in lithium-sulfur (Li-S) batteries. This can be achieved by developing facile methods for the synthesis of novel nanostructured carbon materials that can function as effective cathode hosts. In this paper, we report the scalable synthesis of ordered mesoporous carbon nanosheets (OMCNS) via the etching of self-assembled iron oxide/carbon hybrid nanosheets (IO-C NS), which serve as an advanced sulfur host for Li-S batteries...
December 23, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28007885/inferring-ancestral-recombination-graphs-from-bacterial-genomic-data
#18
Timothy G Vaughan, David Welch, Alexei J Drummond, Patrick J Biggs, Tessy George, Nigel P French
Homologous recombination is a central feature of bacterial evolution, yet confounds traditional phylogenetic methods. While a number of methods specific to bacterial evolution have been developed, none of these permit joint inference of a bacterial recombination graph and associated parameters. In this paper, we present a new method which addresses this shortcoming. Our method uses a novel Markov chain Monte Carlo algorithm to perform phylogenetic inference under the ClonalOrigin model of Didelot et al. (Genetics, 2010)...
December 22, 2016: Genetics
https://www.readbyqxmd.com/read/28003983/essential-infantile-esotropia-with-inferior-oblique-hyperfunction-long-term-follow-up-of-6-muscles-approach
#19
Adriano Magli, Roberta Carelli, Elisabetta Chiariello Vecchio, Francesca Esposito, Luca Rombetto, Paolo Esposito Veneruso
AIM: To evaluate long term follow-up (10y) of 6 muscle surgical approach in essential infantile esotropia (EIE). METHODS: A 6 muscle approach to EIE was retrospectively evaluated in patients with inferior oblique (IO) hyperfunction and lateral rectus (LR) pseudoparalysis, who underwent surgery at different ages. Different clinical characters were analyzed pre- and postoperatively, in patients who underwent a 6 muscles approach ≤4 years of age. All patients underwent a multiple muscles approach: bilateral medial recti (MR) recession (4-5 mm), bilateral LR resection (lower than 7 mm) and bilateral IO recession and anteroposition...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27998615/analysis-of-intraosseous-blood-samples-using-an-epoc-point-of-care-analyzer-during-resuscitation
#20
Crystal Ives Tallman, Michael Darracq, Megann Young
BACKGROUND: In the early phases of resuscitation in a critically ill patient, especially those in cardiac arrest, intravenous (IV) access can be difficult to obtain. Intraosseous (IO) access is often used in these critical situations to allow medication administration. When no IV access is available, it is difficult to obtain blood for point of care analysis, yet this information can be crucial in directing the resuscitation. We hypothesized that IO samples may be used with a point of care device to obtain useful information when seconds really do matter...
December 12, 2016: American Journal of Emergency Medicine
keyword
keyword
29690
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"