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https://www.readbyqxmd.com/read/29776776/reliability-of-the-lateral-abdominal-muscle-thickness-measurements-in-idiopathic-scoliosis-patients
#1
Pawel Linek, Anna Klepek, Tomasz Wolny, Grzegorz Mikołajowski
BACKGROUND: To date, the reliability of ultrasound imaging (US) measures of the abdominal muscle thickness in idiopathic scoliosis (IS) patients during early stages of adolescence has not been confirmed. OBJECTIVE: To assess the intra-rater reliability of US measures of the thickness of the external oblique (EO), internal oblique (IO), and transversus abdominis (TrA) on convex and concave body sides in adolescents with IS. DESIGN: One-way repeated-measures analysis of variance (ANOVA) and reliability study...
May 3, 2018: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29775800/insertion-and-presence-of-fine-wire-intramuscular-electrodes-to-the-lumbar-paraspinal-muscles-do-not-affect-muscle-performance-and-activation-during-high-exertion-spinal-extension-activities
#2
Szu-Ping Lee, Jo Armour Smith, Matthew Kimber, Kelsey Houk
BACKGROUND: Low back pain (LBP) is commonly associated with paraspinal muscle dysfunctions. A method to study deep lumbar paraspinal (i.e. multifidus) muscle function and neuromuscular activation pattern is intramuscular electromyography (EMG). Previous studies have shown that the procedure does not significantly impact muscle function during activities involving low-level muscle contractions. However, it is currently unknown how muscular function and activation are affected during high-exertion contractions...
May 15, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29771869/performance-of-the-atlas-rapid-test-for-chlamydia-trachomatis-and-women-s-attitudes-toward-point-of-care-testing
#3
Lea E Widdice, Yu-Hsiang Hsieh, Barbara Silver, Mathilda Barnes, Perry Barnes, Charlotte A Gaydos
PURPOSE: This study compared performance of Atlas io® diagnostic platform, a point-of-care (POC) PCR assay for Chlamydia trachomatis (CT), to Aptima Combo 2, a standard of care laboratory-based nucleic acid amplification assay (NAAT), and evaluated patient attitudes toward POC testing. METHODS: Women ≥14 years undergoing CT screening/testing were recruited from an urban adolescent primary care practice (Teen Health Center, THC) and a sexually transmitted disease (STD) clinic...
May 1, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29765184/the-effect-of-respiratory-exercise-on-trunk-control-pulmonary-function-and-trunk-muscle-activity-in-chronic-stroke-patients
#4
Dong-Kyu Lee, Se-Hun Kim
[Purpose] This study aims to identify the effect of respiratory exercise on trunk control, pulmonary function, and trunk muscle activity in chronic stroke patients. [Subjects and Methods] The study included 24 chronic stroke patients who were randomly assigned, 12 each, to the experimental and control groups, and received neurodevelopmental treatment. Moreover, the experimental group underwent respiratory exercise. In each patient, the trunk control was measured using the Trunk Impairment Scale (TIS); muscle activity of the trunk, through the surface electromyogram; and pulmonary function, using the pneumatometer...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29762723/pyabc-distributed-likelihood-free-inference
#5
Emmanuel Klinger, Dennis Rickert, Jan Hasenauer
Summary: Likelihood-free methods are often required for inference in systems biology. While Approximate Bayesian Computation (ABC) provides a theoretical solution, its practical application has often been challenging due to its high computational demands. To scale likelihood-free inference to computationally demanding stochastic models we developed pyABC: a distributed and scalable ABC-Sequential Monte Carlo (ABC-SMC) framework. It implements a scalable, runtime-minimizing parallelization strategy for multi-core and distributed environments scaling to thousands of cores...
May 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29760523/combination-of-fucoidan-based-magnetic-nanoparticles-and-immunomodulators-enhances-tumour-localized-immunotherapy
#6
Chih-Sheng Chiang, Yu-Jung Lin, Rachel Lee, Yen-Ho Lai, Hung-Wei Cheng, Chia-Hung Hsieh, Woei-Cherng Shyu, San-Yuan Chen
Checkpoint immunotherapy that inhibits tumour immune evasion has demonstrated significant clinical success. However, the therapeutic response is limited to certain patient populations, and immunotoxicity as well as autoimmunity have compromised the therapeutic benefits. Here, we report on an inherently therapeutic fucoidan-dextran-based magnetic nanomedicine (IO@FuDex3 ) conjugated with a checkpoint inhibitor (anti-PD-L1) and T-cell activators (anti-CD3 and anti-CD28). IO@FuDex3 can repair the immunosuppressive tumour microenvironment by reinvigorating tumour-infiltrating lymphocytes, while targeting the nanomedicine via magnetic navigation to the tumour to minimize off-target effects...
May 14, 2018: Nature Nanotechnology
https://www.readbyqxmd.com/read/29752607/farseer-nmr-automatic-treatment-analysis-and-plotting-of-large-multi-variable-nmr-data
#7
João M C Teixeira, Simon P Skinner, Miguel Arbesú, Alexander L Breeze, Miquel Pons
We present Farseer-NMR ( https://git.io/vAueU ), a software package to treat, evaluate and combine NMR spectroscopic data from sets of protein-derived peaklists covering a range of experimental conditions. The combined advances in NMR and molecular biology enable the study of complex biomolecular systems such as flexible proteins or large multibody complexes, which display a strong and functionally relevant response to their environmental conditions, e.g. the presence of ligands, site-directed mutations, post translational modifications, molecular crowders or the chemical composition of the solution...
May 11, 2018: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/29748864/the-effect-of-intraosseous-local-anesthesia-of-4-articaine-with-1-100-000-epinephrine-on-pulpal-blood-flow-and-pulpal-anesthesia-of-mandibular-molars-and-canines
#8
Kadkao Vongsavan, Tshering Samdrup, Kanittha Kijsamanmith, Praphasri Rirattanapong, Noppakun Vongsavan
OBJECTIVES: The aim of this study was to determine the effect of intraosseous (IO) anesthesia with 4% articaine and 1:100,000 epinephrine on pulpal blood flow (PBF) and pulpal anesthesia of mandibular first molars and canines in human subjects. MATERIALS AND METHODS: Ten healthy volunteers with intact mandibular first molar and canine were given an osteocentral technique of IO injection using the Quick Sleeper 5 system and 4% articaine with 1:100,000 epinephrine at distal site of mandibular first molar...
May 10, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29748008/predicting-outcomes-in-patients-with-advanced-non-small-cell-lung-cancer-enrolled-in-early-phase-immunotherapy-trials
#9
Hossein Maymani, Kenneth Hess, Roman Groisberg, David S Hong, Aung Naing, Sarina Piha-Paul, Filip Janku, Siqing Fu, Apostolia M Tsimberidou, Shubham Pant, Daniel Karp, Shuang Liu, Ming Sun, John Heymach, George Simon, Funda Meric-Bernstam, Vivek Subbiah
OBJECTIVES: Immunotherapy (IO) has altered the non-small cell lung cancer (NSCLC) therapeutic landscape. However, the majority of patients do not respond to immune-checkpoint blockade, and subsequently either receive further chemotherapy or are referred for clinical trials. Here we examined the outcomes and predictors of response to IO in early phase clinical trials. MATERIALS AND METHODS: We analyzed the records of 74 patients with metastatic NSCLC that were enrolled on phase 1 IO trials within MD Anderson Cancer Center from 1/2010 to 7/2017...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29746461/porcupine-a-visual-pipeline-tool-for-neuroimaging-analysis
#10
Tim van Mourik, Lukas Snoek, Tomas Knapen, David G Norris
The field of neuroimaging is rapidly adopting a more reproducible approach to data acquisition and analysis. Data structures and formats are being standardised and data analyses are getting more automated. However, as data analysis becomes more complicated, researchers often have to write longer analysis scripts, spanning different tools across multiple programming languages. This makes it more difficult to share or recreate code, reducing the reproducibility of the analysis. We present a tool, Porcupine, that constructs one's analysis visually and automatically produces analysis code...
May 10, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29743054/australian-integrative-oncology-services-a-mixed-method-study-exploring-the-views-of-cancer-survivors
#11
Jennifer Hunter, Jane Ussher, Chloe Parton, Andrew Kellett, Caroline Smith, Geoff Delaney, Eleanor Oyston
BACKGROUND: The significant use of traditional and complementary medicine (T&CM) by cancer survivors is well documented. The aim of this study was to explore cancer survivors' views on integrating T&CM services with conventional cancer care. METHOD: A mixed-method study design with an emphasis on qualitative methodology was used to conduct and analyse four focus group interviews and an on-line survey. Purposive sampling recruited 33 cancer survivors and caregivers from Arabic, Vietnamese, Chinese and Anglo-European Australian backgrounds who participated in one of four focus group interviews, and 121 cancer survivors who responded to an on-line survey...
May 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29740556/effects-of-abdominal-hollowing-and-abdominal-bracing-during-side-lying-hip-abduction-on-the-lateral-rotation-and-muscle-activity-of-the-pelvis
#12
Dong-Woo Kim, Tae-Ho Kim
It is important that compensatory lateral movement of the pelvis does not occur during side-lying hip abduction (SHA). The purpose of the present study is to investigate the effects of abdominal hollowing and abdominal bracing during SHA on pelvic lateral rotation (PLR) and the electromyography activity of the gluteus medius, quadratus lumborum (QL), external oblique abdominis (EO) and internal oblique abdominis (IO). A total of 22 healthy male adults participated in the study. The subjects performed three conditions in side-lying in random order: SHA with abdominal hollowing (SHA-AH), SHA with abdominal bracing (SHA-AB), and SHA without any condition (SHA-WC)...
April 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29731964/total-body-irradiation-and-iron-chelation-treatment-are-associated-with-pancreatic-injury-following-pediatric-hematopoietic-stem-cell-transplantation
#13
Natalia Maximova, Massimo Gregori, Roberto Simeone, Aurelio Sonzogni, Davide Zanon, Giulia Boz, Lorenzo D'Antiga
Whereas many studies have addressed the risk of organ dysfunction following hematopoietic stem cell transplantation (HSCT), little is known about pancreatic susceptibility in this setting. We aimed to investigate the effect of iron overload (IO) and total body irradiation (TBI) on pancreatic function of children undergoing HSCT. We retrospectively evaluated children admitted between 2012-2016 fulfilling the following criteria: normal pancreatic iron concentration (PIC), regular pancreatic function before HSCT, availability of abdominal magnetic resonance imaging with gradient-recalled-echo sequences and a full set of biochemical markers of IO and pancreatic function performed before HSCT and at discharge...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29726919/canvasdesigner-a-versatile-interactive-high-resolution-scientific-multi-panel-visualization-toolkit
#14
Baohong Zhang, Shanrong Zhao, Isaac Neuhaus
Summary: We present a bioinformatics and systems biology visualization toolkit harmonizing real time interactive exploring and analyzing of big data, full-fledged customizing of look-n-feel, and producing multi-panel publication-ready figures in PDF format simultaneously. Availability: Source code and detailed user guides are available at http://canvasxpress.org, https://baohongz.github.io/canvasDesigner, and https://baohongz.github.io/canvasDesigner/demo_video...
May 3, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29725013/iron-overload-promotes-mitochondrial-fragmentation-in-mesenchymal-stromal-cells-from-myelodysplastic-syndrome-patients-through-activation-of-the-ampk-mff-drp1-pathway
#15
Qingqing Zheng, Youshan Zhao, Juan Guo, Sida Zhao, Chengming Fei, Chao Xiao, Dong Wu, Lingyun Wu, Xiao Li, Chunkang Chang
Iron overload (IO) has been reported to contribute to mesenchymal stromal cell (MSC) damage, but the precise mechanism has yet to be clearly elucidated. In this study, we found that IO increased cell apoptosis and lowered cell viability in MSCs, accompanied by extensive mitochondrial fragmentation and autophagy enhancement. All these effects were reactive oxygen species (ROS) dependent. In MSCs with IO, the ATP concentrations were significantly reduced due to high ROS levels and low electron respiratory chain complex (ETC) II/III activity...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29718213/the-scientific-filesystem-scif
#16
Vanessa Sochat
Background: Here we present the Scientific Filesystem (SCIF), an organizational format that supports exposure of executables and metadata for discoverability of scientific applications. The format includes a known filesystem structure, a definition for a set of environment variables describing it, and functions for generation of the variables and interaction with the libraries, metadata, and executables located within. SCIF makes it easy to expose metadata, multiple environments, installation steps, files, and entrypoints to render scientific applications consistent, modular, and discoverable...
March 13, 2018: GigaScience
https://www.readbyqxmd.com/read/29709957/suffocation-due-to-acute-airway-edema-in-a-patient-with-hereditary-angioedema-highlighted-the-need-for-urgent-improvements-in-treatment-availability-in-japan
#17
Daisuke Honda, Isao Ohsawa, Yuki Shimizu, Masayuki Maiguma, Teruo Hidaka, Hitoshi Suzuki, Hiroaki Io, Satoshi Mano, Hisatsugu Takahara, Hisaki Rinno, Yasuhiko Tomino, Yusuke Suzuki
A 42-year-old Japanese man with hereditary angioedema suffered accidental trauma to his jaw in Shizuoka Prefecture, Japan, which gradually caused facial edema. Since plasma-derived human C1 inhibitor (pdh C1-INH) was unavailable, he had to be transferred to Juntendo University Hospital in Tokyo. Due to his severe edema, he suffered asphyxiation leading to cardiopulmonary arrest upon arrival. The patient was resuscitated and promptly treated with pdh C1-INH. In Japan, the self-administration of pdh C1-INH is not allowed, and every prefecture does not always possess stocks of pdh C1-INH...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29706695/effects-of-deep-breathing-on-internal-oblique-and-multifidus-muscle-activity-in-three-sitting-postures
#18
Min-Joo Ko, Eun-Joo Jung, Moon-Hwan Kim, Jae-Seop Oh
[Purpose] This study was to investigate differences in the level of activity of the external oblique (EO), internal oblique (IO), and multifidus (MF) muscles with deep breathing in three sitting postures. [Subjects and Methods] Sixteen healthy women were recruited. The muscle activity (EO, IO, MF) of all subjects was measured in three sitting postures (slumped, thoracic upright, and lumbo-pelvic upright sitting postures) using surface electromyography. The activity of the same muscles was then remeasured in the three sitting postures during deep breathing...
April 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29705574/automatic-recognition-of-holistic-functional-brain-networks-using-iteratively-optimized-convolutional-neural-networks-io-cnn-with-weak-label-initialization
#19
Yu Zhao, Fangfei Ge, Tianming Liu
fMRI data decomposition techniques have advanced significantly from shallow models such as Independent Component Analysis (ICA) and Sparse Coding and Dictionary Learning (SCDL) to deep learning models such Deep Belief Networks (DBN) and Convolutional Autoencoder (DCAE). However, interpretations of those decomposed networks are still open questions due to the lack of functional brain atlases, no correspondence across decomposed or reconstructed networks across different subjects, and significant individual variabilities...
April 26, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29704131/factors-influencing-stereopsis-in-patients-with-both-refractive-accommodative-esotropia-and-amblyopia
#20
Burçin Çakır, Özlem Bursalı, Sedat Özmen, Nilgün Özkan Aksoy, Tural Babashli, Gursoy Alagöz
PURPOSE: Potential factors influencing stereopsis were investigated in patients with both refractive accommodative esotropia (RAE) and amblyopia. MATERIALS AND METHODS: A retrospective chart review was performed to find out all patients with the diagnosis of both RAE and amblyopia. Patients are classified into two groups: group 1 (with stereopsis) and group 2 (without stereopsis). Onset age of RAE, history of strabismus in family members, time of amblyopia treatment, mean spherical equivalent, anisometropia, ocular movement disorders, especially, overaction of inferior oblique (IO) muscle, visual acuity difference (VAD) between eyes, best-corrected visual acuity (BCVA) levels of amblyopic and normal eyes and the presence of alternation of fixation (AOF) were investigated as possible factors...
April 27, 2018: International Ophthalmology
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