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https://www.readbyqxmd.com/read/28527529/image-guided-ablation-of-renal-cell-carcinoma
#1
REVIEW
T M Wah
This review article aims to provide an overview of image-guided ablation of renal cell carcinoma (RCC) since it was first introduced in 1998. This will cover the background and rationale behind its development; an overview of the evidence for current thermal technology, such as heat-based, e.g., radiofrequency ablation (RFA), microwave ablation (MWA), and cold-based energies, e.g., cryoablation used; and summarise the published evidence regarding its treatment efficacy and oncological outcome. In addition, it aims to provide an insight into the potential role of the new non-thermal ablative technology, e...
May 17, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28523601/the-provo-corpus-a-large-eye-tracking-corpus-with-predictability-norms
#2
Steven G Luke, Kiel Christianson
This article presents the Provo Corpus, a corpus of eye-tracking data with accompanying predictability norms. The predictability norms for the Provo Corpus differ from those of other corpora. In addition to traditional cloze scores that estimate the predictability of the full orthographic form of each word, the Provo Corpus also includes measures of the predictability of the morpho-syntactic and semantic information for each word. This makes the Provo Corpus ideal for studying predictive processes in reading...
May 18, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28523006/virtual-plant-tissue-building-blocks-for-next-generation-plant-growth-simulation
#3
Dirk De Vos, Abdiravuf Dzhurakhalov, Sean Stijven, Przemyslaw Klosiewicz, Gerrit T S Beemster, Jan Broeckhove
Motivation: Computational modeling of plant developmental processes is becoming increasingly important. Cellular resolution plant tissue simulators have been developed, yet they are typically describing physiological processes in an isolated way, strongly delimited in space and time. Results: With plant systems biology moving toward an integrative perspective on development we have built the Virtual Plant Tissue (VPTissue) package to couple functional modules or models in the same framework and across different frameworks...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28516912/a-complete-tool-set-for-molecular-qtl-discovery-and-analysis
#4
Olivier Delaneau, Halit Ongen, Andrew A Brown, Alexandre Fort, Nikolaos I Panousis, Emmanouil T Dermitzakis
Population scale studies combining genetic information with molecular phenotypes (for example, gene expression) have become a standard to dissect the effects of genetic variants onto organismal phenotypes. These kinds of data sets require powerful, fast and versatile methods able to discover molecular Quantitative Trait Loci (molQTL). Here we propose such a solution, QTLtools, a modular framework that contains multiple new and well-established methods to prepare the data, to discover proximal and distal molQTLs and, finally, to integrate them with GWAS variants and functional annotations of the genome...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28505247/single-cell-regulome-data-analysis-by-scrat
#5
Zhicheng Ji, Weiqiang Zhou, Hongkai Ji
Summary: Emerging single-cell technologies (e.g., single-cell ATAC-seq, DNase-seq or ChIP-seq) have made it possible to assay regulome of individual cells. Single-cell regulome data are highly sparse and discrete. Analyzing such data is challenging. User-friendly software tools are still lacking. We present SCRAT, a Single-Cell Regulome Analysis Toolbox with a graphical user interface, for studying cell heterogeneity using single-cell regulome data. SCRAT can be used to conveniently summarize regulatory activities according to different features (e...
May 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28503534/effects-of-three-spinal-stabilization-techniques-on-activation-and-thickness-of-abdominal-muscle
#6
Byeong-Jo Kim, Su-Kyoung Lee
In this study, we examine the thickness of the abdominal muscle and its activity during the performance of the three drawing-in methods. The subjects were 20 healthy male and female students in their 20s. Using ultrasonography and electromyography, the experimenter measured the thickness of the transversus abdominis (TrA) muscle, internal oblique (IO) muscle and external oblique (EO) muscle. The ultrasonography measurements for the drawing-in manoeuver (DI), abdominal bracing, and posterior pelvic tilt (PT) techniques were 0...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28502411/abdominal-bracing-during-lifting-alters-trunk-muscle-activity-and-body-kinematics
#7
Pieter Coenen, Amity Campbell, Kevin Kemp-Smith, Peter O'Sullivan, Leon Straker
We assessed whether participants are able to perform abdominal bracing during lifting, and described its effects on trunk muscle activity and body kinematics. Fourteen participants performed 10 lifts (symmetrical lifting of a 15 kg load from floor level), 5 with abdominal bracing and 5 without. Activity of the lumbar multifidus (LM) and internal oblique (IO) muscles, and trunk and lower body kinematics were obtained. During non-bracing lifting, IO activity did not increase beyond rested standing levels (with average muscle activity ranging between 8...
September 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28500463/comparison-of-four-different-intraosseous-access-devices-during-simulated-pediatric-resuscitation-a-randomized-crossover-manikin-trial
#8
Karol Bielski, Lukasz Szarpak, Jacek Smereka, Jerzy R Ladny, Steve Leung, Kurt Ruetzler
The aim of the study was to compare the success rate, procedure time, and user satisfaction of pediatric NIO™ compared to Pediatric BIG®, EZ-IO®, and Jamshidi intraosseous access devices. This was a randomized, crossover manikin trial with 87 paramedics. The correct location of intraosseous access when using NIO, BIG, EZ-IO, and Jamshidi was varied and was respectively 100, 90, 90, and 90%. The time required to obtain intravascular access (time T1) in the case of NIO, BIG, EZ-IO, and Jamshidi was varied and amounted to 9 s [IQR, 8-12] for NIO, 12 s [IQR, 9-16] for BIG, 13...
May 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28498899/magenta-a-galaxy-implemented-tool-for-complete-tn-seq-analysis-and-data-visualization
#9
Katherine Maia McCoy, Margaret L Antonio, Tim van Opijnen
Motivation: Transposon insertion sequencing (Tn-Seq) is a microbial systems-level tool, that can determine on a genome-wide scale and in high-throughput, whether a gene, or a specific genomic region, is important for fitness under a specific experimental condition. Results: Here, we present MAGenTA, a suite of analysis tools which accurately calculate the growth rate for each disrupted gene in the genome to enable the discovery of: a) new leads for gene function, b) non coding RNAs; c) genes, pathways and ncRNAs that are involved in tolerating drugs or induce disease; d) higher order genome organization; and e) host-factors that affect bacterial host susceptibility...
May 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28492251/multi-phase-volcanic-resurfacing-at-loki-patera-on-io
#10
K de Kleer, M Skrutskie, J Leisenring, A G Davies, A Conrad, I de Pater, A Resnick, V Bailey, D Defrère, P Hinz, A Skemer, E Spalding, A Vaz, C Veillet, C E Woodward
The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering 21,500 square kilometres surrounding a much cooler central 'island'. The temperature gradient seen across areas of the patera indicates a systematic resurfacing process, which has been seen to occur typically every one to three years since the 1980s. Analysis of past data has indicated that the resurfacing progressed around the patera in an anti-clockwise direction at a rate of one to two kilometres per day, and that it is caused either by episodic eruptions that emplace voluminous lava flows or by a cyclically overturning lava lake contained within the patera...
May 10, 2017: Nature
https://www.readbyqxmd.com/read/28487249/combining-tdcs-with-prismatic-adaptation-for-non-invasive-neuromodulation-of-the-motor-cortex
#11
Martina Bracco, Giuseppa Renata Mangano, Patrizia Turriziani, Daniela Smirni, Massimiliano Oliveri
BACKGROUND: Prismatic adaptation (PA) shifts visual field laterally and induces lateralized deviations of spatial attention. Recently, it has been suggested that prismatic goggles are also able to modulate brain excitability, with cognitive after-effects documented even in tasks not necessarily spatial in nature. OBJECTIVE: The aim of the present study was to test whether neuromodulatory effects obtained from tDCS and prismatic goggles could interact and induce homeostatic changes in corticospinal excitability...
May 6, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28483225/mandarin-compound-vowels-produced-by-prelingually-deafened-children-with-cochlear-implants
#12
Jing Yang, Li Xu
OBJECTIVE: Compound vowels including diphthongs and triphthongs have complex, dynamic spectral features. The production of compound vowels by children with cochlear implants (CIs) has not been studied previously. The present study examined the dynamic features of compound vowels in native Mandarin-speaking children with CIs. METHODS: Fourteen prelingually deafened children with CIs (aged 2.9-8.3 years old) and 14 age-matched, normal-hearing (NH) children produced monosyllables containing six Mandarin compound vowels (i...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28482358/continental-crust-formation-on-early-earth-controlled-by-intrusive-magmatism
#13
A B Rozel, G J Golabek, C Jain, P J Tackley, T Gerya
The global geodynamic regime of early Earth, which operated before the onset of plate tectonics, remains contentious. As geological and geochemical data suggest hotter Archean mantle temperature and more intense juvenile magmatism than in the present-day Earth, two crust-mantle interaction modes differing in melt eruption efficiency have been proposed: the Io-like heat-pipe tectonics regime dominated by volcanism and the "Plutonic squishy lid" tectonics regime governed by intrusive magmatism, which is thought to apply to the dynamics of Venus...
May 8, 2017: Nature
https://www.readbyqxmd.com/read/28470979/activatable-singlet-oxygen-generation-from-lipid-hydroperoxide-nanoparticles-for-cancer-therapy
#14
Zijian Zhou, Jibin Song, Rui Tian, Zhen Yang, Guocan Yu, Lisen Lin, Guofeng Zhang, Wenpei Fan, Fuwu Zhang, Gang Niu, Liming Nie, Xiaoyuan Chen
Reactive oxygen species (ROS)-induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantage of the spatial-temporal control of ROS generation, the meticulous participation of light, photosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line cancer treatment option. An activatable system has been developed that enables tumor-specific singlet oxygen ((1) O2 ) generation for cancer therapy, based on a Fenton-like reaction between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic-pH condition...
May 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28470045/low-data-drug-discovery-with-one-shot-learning
#15
Han Altae-Tran, Bharath Ramsundar, Aneesh S Pappu, Vijay Pande
Recent advances in machine learning have made significant contributions to drug discovery. Deep neural networks in particular have been demonstrated to provide significant boosts in predictive power when inferring the properties and activities of small-molecule compounds (Ma, J. et al. J. Chem. Inf. MODEL: 2015, 55, 263-274). However, the applicability of these techniques has been limited by the requirement for large amounts of training data. In this work, we demonstrate how one-shot learning can be used to significantly lower the amounts of data required to make meaningful predictions in drug discovery applications...
April 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28464826/microtaboo-a-general-and-practical-solution-to-the-k-disjoint-problem
#16
Mohammed Al-Jaff, Eric Sandström, Manfred Grabherr
BACKGROUND: A common challenge in bioinformatics is to identify short sub-sequences that are unique in a set of genomes or reference sequences, which can efficiently be achieved by k-mer (k consecutive nucleotides) counting. However, there are several areas that would benefit from a more stringent definition of "unique", requiring that these sub-sequences of length W differ by more than k mismatches (i.e. a Hamming distance greater than k) from any other sub-sequence, which we term the k-disjoint problem...
May 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28453682/distributedfba-jl-high-level-high-performance-flux-balance-analysis-in-julia
#17
Laurent Heirendt, Ines Thiele, Ronan M T Fleming
Motivation: Flux balance analysis and its variants are widely used methods for predicting steady-state reaction rates in biochemical reaction networks. The exploration of high dimensional networks with such methods is currently hampered by software performance limitations. Results: DistributedFBA.jl is a high-level, high-performance, open-source implementation of flux balance analysis in Julia. It is tailored to solve multiple flux balance analyses on a subset or all the reactions of large and huge-scale networks, on any number of threads or nodes...
May 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28449110/veqtl-mapper-variance-association-mapping-for-molecular-phenotypes
#18
Andrew Anand Brown
Motivation: Genetic loci associated with the variance of phenotypic traits have been of recent interest as they can be signatures of genetic interactions, gene by environment interactions, parent of origin effects and canalisation. We present a fast efficient tool to map loci affecting variance of gene expression and other molecular phenotypes in cis. Results: Applied to the publicly available Geuvadis gene expression dataset, we identify 816 loci associated with variance of gene expression using an additive model, and 32 showing differences in variance between homozygous and heterozygous alleles, signatures of parent of origin effects...
April 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28442139/intraoperative-ultrasound-assisted-approach-for-endoscopic-treatment-of-vesicoureteral-reflux-in-children
#19
Elisa Zambaiti, Maria Sergio, Alessandra Casuccio, Sergio Salerno, Marcello Cimador
PURPOSE: Despite minimal invasiveness and high success rate, guidelines still prescribe voiding Cystourethrogram (VCUG) after endoscopic treatment for vesicoureteral reflux (VUR) in children. The aim of this paper was to analyze whether intraoperative ultrasound (IO-US) could improve surgical accuracy and perioperative counseling, thus potentially decreasing the need for postoperative VCUG. METHODS: We selected children treated for moderate to high grade VUR, renal scarring or repeated infections under antibiotic prophylaxis from January to December 2015...
April 18, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28438472/shared-metabolic-and-immune-inflammatory-oxidative-and-nitrosative-stress-pathways-in-the-metabolic-syndrome-and-mood-disorders
#20
REVIEW
Luiz Gustavo Piccoli de Melo, Sandra Odebrecht Vargas Nunes, George Anderson, Heber Odebrecht Vargas, Décio Sabbattini Barbosa, Piotr Galecki, André F Carvalho, Michael Maes
This review examines the shared immune-inflammatory, oxidative and nitrosative stress (IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder (BD) and major depressive disorder (MDD). Shared pathways in both MetS and mood disorders are low grade inflammation, including increased levels of pro-inflammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol...
April 21, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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