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https://www.readbyqxmd.com/read/28437332/ultrasound-assessment-of-the-abdominal-muscles-at-rest-and-during-the-aslr-test-among-adolescents-with-scoliosis
#1
Paweł Linek, Edward Saulicz, Michał Kuszewski, Tomasz Wolny
STUDY DESIGN: Observational study. OBJECTIVE: Are there deviations in the thickness of abdominal muscles at rest in individuals with adolescent idiopathic scoliosis (AIS)? Are there deviations in abdominal muscular activity in people with AIS during the active straight leg raise (ASLR) test? SUMMARY OF BACKGROUND DATA: Ultrasound imaging can be used to assess the lateral abdominal muscle. Some authors suggest that scoliosis develops through a weakness or improper functioning of the abdominal muscles that cannot provide adequate support to the spinal segments...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28436466/genome-wide-profiling-of-heritable-and-de-novo-str-variations
#2
Thomas Willems, Dina Zielinski, Jie Yuan, Assaf Gordon, Melissa Gymrek, Yaniv Erlich
Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple genetic diseases, population genetics applications, and forensic casework. However, it has proven problematic to genotype STRs from high-throughput sequencing data. Here, we describe HipSTR, a novel haplotype-based method for robustly genotyping and phasing STRs from Illumina sequencing data, and we report a genome-wide analysis and validation of de novo STR mutations. HipSTR is freely available at https://hipstr-tool...
April 24, 2017: Nature Methods
https://www.readbyqxmd.com/read/28424704/draco-stem-an-automatic-tool-to-generate-high-quality-3d-meshes-of-shoot-apical-meristem-tissue-at-cell-resolution
#3
Guillaume Cerutti, Olivier Ali, Christophe Godin
Context: The shoot apical meristem (SAM), origin of all aerial organs of the plant, is a restricted niche of stem cells whose growth is regulated by a complex network of genetic, hormonal and mechanical interactions. Studying the development of this area at cell level using 3D microscopy time-lapse imaging is a newly emerging key to understand the processes controlling plant morphogenesis. Computational models have been proposed to simulate those mechanisms, however their validation on real-life data is an essential step that requires an adequate representation of the growing tissue to be carried out...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28418753/intraosseous-pressure-monitoring-in-healthy-volunteers
#4
Joshua G Salzman, Nicholas M Loken, Sandi S Wewerka, Aaron M Burnett, Abigail E Zagar, Kent R Griffith, Peter L Bliss, Bjorn K Peterson, Christopher J Ward, Ralph J Frascone
STUDY OBJECTIVE: Invasively monitoring blood pressure through the IO device has not been thoroughly demonstrated. This study attempted to establish baseline values of IO pressure in a healthy human population. METHODS: This was a prospective, healthy volunteer, observational study. Participants had two IO devices placed (humerus and tibia), and participant IO pressures, vital signs, and pain scores were monitored for up to 60 minutes. Participants were contacted at 24-hours and 7 days post-testing to assess for adverse events...
April 18, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28409486/dutch-taboo-norms
#5
Sander A Roest, Tessa A Visser, René Zeelenberg
This article provides norms for general taboo, personal taboo, insult, valence, and arousal for 672 Dutch words, including 202 taboo words. Norms were collected using a 7-point Likert scale and based on ratings by psychology students from the Erasmus University Rotterdam in The Netherlands. The sample consisted of 87 psychology students (58 females, 29 males). We obtained high reliability based on split-half analyses. Our norms show high correlations with arousal and valence ratings collected by another Dutch word-norms study (Moors et al...
April 13, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28407033/biocider-a-contextualisation-index-for-biological-resources-discovery
#6
Carlos Horro, Martin Cook, Teresa K Attwood, Michelle D Brazas, John M Hancock, Patricia Palagi, Manuel Corpas, Rafael Jimenez
Summary: The vast, uncoordinated proliferation of bioinformatics resources (databases, software tools, training materials, etc .) makes it difficult for users to find them. To facilitate their discovery, various services are being developed to collect such resources into registries. We have developed BioCIDER, which, rather like online shopping 'recommendations', provides a contextualisation index to help identify biological resources relevant to the content of the sites in which it is embedded...
April 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28402395/mzml2isa-nmrml2isa-generating-enriched-isa-tab-metadata-files-from-metabolomics-xml-data
#7
Martin Larralde, Thomas N Lawson, Ralf J M Weber, Pablo Moreno, Kenneth Haug, Philippe Rocca-Serra, Mark R Viant, Christoph Steinbeck, Reza M Salek
Summary: Submission to the MetaboLights repository for metabolomics data currently places the burden of reporting instrument and acquisition parameters in ISA-Tab format on users, who have to do it manually, a process that is time consuming and prone to user input error. Since the large majority of these parameters are embedded in instrument raw data files, an opportunity exists to capture this metadata more accurately. Here we report a set of Python packages that can automatically generate ISA-Tab metadata file stubs from raw XML metabolomics data files...
April 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28399443/the-effect-of-inspiratory-and-expiratory-loads-on-abdominal-muscle-activity-during-breathing-in-subjects-at-risk-for-the-development-of-chronic-obstructive-pulmonary-disease-and-healthy
#8
António Mesquita Montes, Carlos Crasto, Cristina Argel de Melo, Rita Santos, Susana Pereira, João Paulo Vilas-Boas
The abdominal muscle activity has been shown to be variable in subjects with chronic obstructive pulmonary disease (COPD) when respiratory demand increases and their recruitment pattern may change the mechanics, as well as the work and cost of breathing. The scientific evidence in subjects "at risk" for the development of COPD may be important to understand the natural history of this disease. This study aims to evaluate the effect of inspiratory and expiratory loads on the abdominal muscle activity during breathing in subjects "at risk" for the development of COPD and healthy...
March 31, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28395655/sbpipe-a-collection-of-pipelines-for-automating-repetitive-simulation-and-analysis-tasks
#9
Piero Dalle Pezze, Nicolas Le Novère
BACKGROUND: The rapid growth of the number of mathematical models in Systems Biology fostered the development of many tools to simulate and analyse them. The reliability and precision of these tasks often depend on multiple repetitions and they can be optimised if executed as pipelines. In addition, new formal analyses can be performed on these repeat sequences, revealing important insights about the accuracy of model predictions. RESULTS: Here we introduce SBpipe, an open source software tool for automating repetitive tasks in model building and simulation...
April 10, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28392051/evaluating-the-femoral-side-critical-corner-in-posterior-cruciate-ligament-reconstruction-the-effect-of-outside-in-versus-inside-out-creation-of-femoral-tunnels-on-graft-contact-pressure-in-a-synthetic-knee-model
#10
Steven J Narvy, George F Hatch, Hansel E Ihn, Nathanael D Heckmann, Michelle H McGarry, James E Tibone, Thay Q Lee
PURPOSE: To characterize and compare the graft contact characteristics of outside-in (OI) and inside-out (IO) femoral tunnels during single-bundle reconstruction of the anterolateral bundle of the posterior cruciate ligament in a synthetic knee model. METHODS: Femoral tunnels were separately made in 16 synthetic femora (8 OI and 8 IO). Achilles tendon allografts were fixed using suspensory fixation with a pressure sensor between the allograft and femoral tunnel...
April 6, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28389853/toward-the-development-of-a-feature-space-representation-for-a-complex-natural-category-domain
#11
Robert M Nosofsky, Craig A Sanders, Brian J Meagher, Bruce J Douglas
This article reports data sets aimed at the development of a detailed feature-space representation for a complex natural category domain, namely 30 common subtypes of the categories of igneous, metamorphic, and sedimentary rocks. We conducted web searches to develop a library of 12 tokens each of the 30 subtypes, for a total of 360 rock pictures. In one study, subjects provided ratings along a set of 18 hypothesized primary dimensions involving visual characteristics of the rocks. In other studies, subjects provided similarity judgments among pairs of the rock tokens...
April 7, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28389222/cesarean-delivery-in-the-second-stage-of-labor-and-the-risk-of-subsequent-premature-birth
#12
Stephen L Wood, Selphee Tang, Susan Crawford
BACKGROUND: Cesarean delivery is being increasingly used by obstetricians for indicated deliveries in the second stage of labor. Unplanned extension of the uterine incision involving the cervix often occurs with these surgeries. Therefore, we hypothesized that cesarean delivery in the second stage of labor may increase the rate of subsequent spontaneous premature birth. OBJECTIVE: We sought to determine if cesarean delivery in the late first stage of labor or in the second stage of labor increases the risk of a subsequent spontaneous preterm birth...
April 4, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28389059/renal-response-to-a-protein-load-in-healthy-young-adults-as-determined-by-iohexol-infusion-clearance-cimetidine-inhibited-creatinine-clearance-and-cystatin-c-estimated-glomerular-filtration-rate
#13
Kyle E Rodenbach, Dana Y Fuhrman, Paula S Maier, George J Schwartz
OBJECTIVE: Renal reserve (RR) measures the increase in glomerular filtration rate (GFR) in response to a protein load; lack of RR could indicate subclinical kidney disease but such a test is not routinely used in clinical practice. The purpose of this study was to compare a meat versus liquid protein load in a cystatin C-based (Cys-C) RR test using cimetidine-inhibited creatinine clearance (Cr Cl) and iohexol infusion clearance (Io Cl) for validation. The design was cross-sectional analysis and the setting was a Clinical Research Center...
April 4, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28388646/bayesian-evaluation-of-effect-size-after-replicating-an-original-study
#14
Robbie C M van Aert, Marcel A L M van Assen
The vast majority of published results in the literature is statistically significant, which raises concerns about their reliability. The Reproducibility Project Psychology (RPP) and Experimental Economics Replication Project (EE-RP) both replicated a large number of published studies in psychology and economics. The original study and replication were statistically significant in 36.1% in RPP and 68.8% in EE-RP suggesting many null effects among the replicated studies. However, evidence in favor of the null hypothesis cannot be examined with null hypothesis significance testing...
2017: PloS One
https://www.readbyqxmd.com/read/28383656/premosa-extracting-2d-surfaces-from-3d-microscopy-mosaics
#15
Corinna Blasse, Stephan Saalfeld, Raphaël Etournay, Andreas Sagner, Suzanne Eaton, Eugene W Myers
Motivation: A significant focus of biological research is to understand the development, organization and function of tissues. A particularly productive area of study is on single layer epithelial tissues in which the adherence junctions of cells form a 2D manifold that is fluorescently labeled. Given the size of the tissue, a microscope must collect a mosaic of overlapping 3D stacks encompassing the stained surface. Downstream interpretation is greatly simplified by preprocessing such a dataset as follows: (a) extracting and mapping the stained manifold in each stack into a single 2D projection plane, (b) correcting uneven illumination artifacts, (c) stitching the mosaic planes into a single, large 2D image, and (d) adjusting the contrast...
April 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28379024/-comments-on-current-guidelines-of-type-2-diabetes-mellitus-treatment
#16
Emil Martinka
In an effort to facilitate the widest possible application of recent findings in diabetology and the related medical fields, with regard to characteristics of medicines and current possibilities of using modern procedures, but also to their limitations due to the financial capacities of health insurance companies, SDS innovates its therapeutic recommendations for the treatment of diabetes mellitus on a regular basis. The most recent recommendations were issued by SDS in August 2016. The review discusses and describes several factors which the authors considered during their preparation: (1) Compliance with the findings of evidence-based medicine, compliance with reference recommendations (therapeutic recommendations ADA/EASD), compliance with summary characteristics of active substances in the treatment of diabetes mellitus and approved possibilities of their use, and compliance with indica-tive restrictions (IO) which define medical and economic conditions for health insurance covered treatment...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28378250/introduction-to-bayesian-inference-for-psychology
#17
Alexander Etz, Joachim Vandekerckhove
We introduce the fundamental tenets of Bayesian inference, which derive from two basic laws of probability theory. We cover the interpretation of probabilities, discrete and continuous versions of Bayes' rule, parameter estimation, and model comparison. Using seven worked examples, we illustrate these principles and set up some of the technical background for the rest of this special issue of Psychonomic Bulletin & Review. Supplemental material is available via https://osf.io/wskex/ .
April 4, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28377023/percutaneous-ultrasound-guided-vs-intraoperative-rectus-sheath-block-for-pediatric-umbilical-hernia-repair-a-randomized-clinical-trial
#18
Cristen N Litz, Sandra M Farach, Allison M Fernandez, Richard Elliott, Jenny Dolan, Nikhil Patel, Lillian Zamora, Paul M Colombani, Nebbie E Walford, Ernest K Amankwah, Christopher W Snyder, Paul D Danielson, Nicole M Chandler
BACKGROUND: Regional anesthesia is commonly used in children. Our hypothesis was that percutaneous ultrasound-guided (PERC) rectus sheath blocks would result in lower postoperative pain scores compared to intraoperative (IO) rectus sheath blocks following umbilical hernia repair. METHODS: A single-institution randomized blinded trial was conducted in pediatric patients undergoing elective umbilical hernia repair. The primary outcome was mean postoperative Wong-Baker pain score...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28373085/choose-your-cell-model-wisely-the-in-vitro-nanoneurotoxicity-of-differentially-coated-iron-oxide-nanoparticles-for-neural-cell-labeling
#19
Freya Joris, Daniel Valdepérez, Beatriz Pelaz, Tianqiang Wang, Shareen H Doak, Bella B Manshian, Stefaan J Soenen, Wolfgang J Parak, Stefaan C De Smedt, Koen Raemdonck
Currently, there is a large interest in the labeling of neural stem cells (NSCs) with iron oxide nanoparticles (IONPs) to allow MRI-guided detection after transplantation in regenerative medicine. For such biomedical applications, excluding nanotoxicity is key. Nanosafety is primarily evaluated in vitro where an immortalized or cancer cell line of murine origin is often applied, which is not necessarily an ideal cell model. Previous work revealed clear neurotoxic effects of PMA-coated IONPs in distinct cell types that could potentially be applied for nanosafety studies regarding neural cell labeling...
March 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28370793/vaginal-delivery-after-placental-abruption-with-intrauterine-fetal-death-a-20-year-single-center-experience
#20
Ayami Inoue, Eiji Kondoh, Koh Suginami, Shingo Io, Yoshitsugu Chigusa, Ikuo Konishi
AIM: The aim of this study was to elucidate the feasibility and safety of vaginal delivery (VD) when placental abruption causes fetal demise. METHODS: We conducted a retrospective study of women who were managed for placental abruption with intrauterine fetal death at Kyoto University Hospital during the period from 1995 to 2015. RESULTS: Sixteen cases were identified during the study period. VD was attempted in 15 cases and was accomplished in 14 (93...
March 28, 2017: Journal of Obstetrics and Gynaecology Research
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