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https://www.readbyqxmd.com/read/29655960/systemic-redox-biomarkers-and-their-relationship-to-prognostic-risk-markers-in-autosomal-dominant-polycystic-kidney-disease-and-iga-nephropathy
#1
Ambreen Tariq, Mohammad A Mansoor, Hans-Peter Marti, Grete Jonsson, Audun Slettan, Pabasara Weeraman, Terje Apeland
BACKGROUND: Oxidative stress is evident from an early stage in chronic kidney disease (CKD). Therefore, we investigated redox biomarkers in polycystic kidney disease (ADPKD) and IgA nephropathy (IGAN). METHODS: This is a case-control study with three groups: ADPKD (n = 54), IGAN (n = 58) and healthy controls (n = 86). The major plasma aminothiols with their redox species were examined: homocysteine (Hcy), cysteinglycine (CG), cysteine (Cys) and glutathione (GSH)...
April 12, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29619905/etiological-analysis-of-graft-dysfunction-following-living-kidney-transplantation-a-report-of-366-biopsies
#2
Jin Zhang, Jiang Qiu, Guo-Dong Chen, Chang-Xi Wang, Chang Wang, Shuang-Jin Yu, Li-Zhong Chen
AIM: The aim of this study is to investigate the clinical features of graft dysfunction following living kidney transplantation and to assess its causes. METHODS: We retrospectively analyzed a series of 366 living kidney transplantation indication biopsies with a clear etiology and diagnosis from July 2003 to June 2016 at our center. The classifications and diagnoses were performed based on clinical and pathological characteristics. All biopsies were evaluated according to the Banff 2007 schema...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29619862/characteristics-of-patients-with-coexisting-iga-nephropathy-and-membranous-nephropathy
#3
Pei Chen, Su-Fang Shi, Zhen Qu, Na Zhao, Xin-Fang Xie, Ji-Cheng Lv, Li-Jun Liu, Hong Zhang
BACKGROUND: Coexistence of IgA nephropathy (IgAN) and membranous nephropathy (MN) in the same patient is rare. Few studies have reported the clinical and pathological features of patients with combined IgAN and MN (IgAN-MN). METHODS: The clinico-pathological features, levels of galactose-deficient IgA1 (Gd-IgA1) and autoantibodies against M-type transmembrane phospholipase A2 receptor (anti-PLA2 R) in sera were compared among IgAN-MN, IgAN, and MN patients. RESULTS: Twenty-six patients with biopsy-proven IgAN-MN were enrolled...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29607256/the-modern-spectrum-of-biopsy-proven-renal-disease-in-chinese-diabetic-patients-a-retrospective-descriptive-study
#4
Diankun Liu, Ting Huang, Nan Chen, Gang Xu, Ping Zhang, Yang Luo, Yongping Wang, Tao Lu, Long Wang, Mengqi Xiong, Jian Geng, Sheng Nie
Background: Renal biopsies performed in diabetic patients are increasing and becoming more complex. Comprehensive data on modern spectrum of biopsy-proven renal disease in Chinese diabetic patients are lacking. Methods: In a nationwide renal biopsy survey including 71,151 native biopsies from 2004 to 2014, diabetic patients were identified according to the clinical diagnosis from referral records. The clinical data were extracted from referral records and pathological reports...
2018: PeerJ
https://www.readbyqxmd.com/read/29606986/candidate-urine-peptide-biomarkers-for-iga-nephropathy-where-are-we-now
#5
REVIEW
Karolina Marek-Bukowiec, Andrzej Konieczny, Krzysztof Ratajczyk, Wojciech Witkiewicz
Early detection, prognosis, and management of IgA nephropathy (IgAN) remain a challenge. Histological examination of renal tissue still comprises the only way to confirm an IgAN diagnosis. It is of great importance to establish noninvasive diagnostic, prognostic, and predictive biomarkers that would improve the clinical care and outcome of patients suffering from IgAN. This review summarises the findings from previous mass spectrometry- (MS-) based studies dedicated to the discovery of urinary peptide profiles specific to IgAN...
2018: Disease Markers
https://www.readbyqxmd.com/read/29606258/treatment-of-iga-nephropathy-recent-advances-and-prospects
#6
REVIEW
Rosanna Coppo
IgA nephropathy, identified 50 years ago in France, is the most frequent glomerular disease worldwide. The course is variable, but in most of the cases there is a relentless decline in renal function, reaching end-stage renal failure in 10-60% of the cases after 10 years and in 40% after 20 years. These data justify the interest for finding a suitable therapeutic approach particularly in progressive cases. A supportive care, including renin-angiotensin system inhibitors is the priority in cases with slowly declining renal function, particularly when developing proteinuria...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29594140/trem-1-contributes-to-inflammation-in-iga-nephropathy
#7
Yan-Feng Zhao, Li Zhu, Li-Jun Liu, Su-Fang Shi, Ji-Cheng Lv, Hong Zhang
Background: Circulating IgA1-containing immune complexes (cIgA1) were shown to play important roles in IgA nephropathy (IgAN). They could induce the release of multiple inflammatory factors, including MCP-1 and IL-6, and elevated urinary inflammatory factors were also reported in patients with IgAN, which suggested that inflammation is a major contributor to kidney injury in IgAN. After the previous identification of the upregulated release of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) by mesangial cells under cIgA1 challenge using cytokine array, in the present study, we further explored the role of TREM-1, an amplifier of inflammation, in cIgA1-induced kidney injury...
February 2018: Kidney Diseases
https://www.readbyqxmd.com/read/29594138/changes-in-the-spectrum-of-kidney-diseases-an-analysis-of-40-759-biopsy-proven-cases-from-2003-to-2014-in-china
#8
Jin-Hua Hou, Hui-Xian Zhu, Min-Lin Zhou, Wei-Bo Le, Cai-Hong Zeng, Shao-Shan Liang, Feng Xu, Dan-Dan Liang, Si-Jia Shao, Ye Liu, Zhi-Hong Liu
Objectives: To evaluate the changing spectrum of kidney diseases over time in China using renal biopsy-proven cases. Methods: All patients over the age of 14 years who were diagnosed with a kidney disease by renal biopsy in the Renal Biopsy Registry of the National Clinical Research Center of Kidney Diseases in Jinling Hospital, Nanjing, from 2003 to 2014 were included. Results: In total, 40,759 cases of renal biopsy were analyzed. The mean age of the patients was 36...
February 2018: Kidney Diseases
https://www.readbyqxmd.com/read/29568935/integrated-analysis-of-b%C3%A2-cell-and-t%C3%A2-cell-receptors-by-high%C3%A2-throughput-sequencing-reveals-conserved-repertoires-in-iga-nephropathy
#9
Minglin Ou, Fengping Zheng, Xinzhou Zhang, Song Liu, Donge Tang, Peng Zhu, Jingjun Qiu, Yong Dai
Immunoglobulin A nephropathy (IgAN) is a type of glomerular disorder associated with immune dysregulation, and understanding B‑/T‑cell receptors (BCRs/TCRs) may be valuable for the development of specific immunotherapeutic interventions. In the present study, B and T cells were isolated from IgAN patients and healthy controls, and the composition of the BCR/TCR complementarity‑determining region (CDR)3 was analyzed by multiplex polymerase chain reaction, high‑throughput sequencing and bioinformatics...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29564665/the-features-in-iga-dominant-infection-related-glomerulonephritis-distinct-from-iga-nephropathy-a-single-center-study
#10
Takaya Handa, Hiroko Kakita, Yu Tateishi, Tomomi Endo, Hiroyuki Suzuki, Toshiro Katayama, Tatsuo Tsukamoto, Eri Muso
BACKGROUND: IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN). METHODS: Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by > 50%...
March 21, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29555434/kidney-failure-risk-prediction-equations-in-iga-nephropathy-a-multicenter-risk-assessment-study-in-chinese-patients
#11
Jingyuan Xie, Jicheng Lv, Weiming Wang, Guisen Li, Zhangsuo Liu, Hongyu Chen, Feifei Xu, Jing Sun, Yan Ouyang, Xiaoyan Zhang, Meng Yang, Manman Shi, Wen Zhang, Hong Ren, Krzysztof Kiryluk, Hong Zhang, Nan Chen
BACKGROUND: The clinical course of immunoglobulin A (IgA) nephropathy (IgAN) is highly variable, making it difficult to predict which patients are at risk for rapid progression. The aim of this study was to develop and validate a kidney failure risk prediction equation for adults with IgAN. STUDY DESIGN: Multicenter retrospective cohort study of 2,155 Chinese patients with IgAN. CANDIDATE PREDICTORS: Clinical and histology variables. OUTCOMES: Time to end-stage renal disease (ESRD)...
March 16, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29551516/interleukin-6-is-essential-for-glomerular-immunoglobulin-a-deposition-and-the-development-of-renal-pathology-in-cd37-deficient-mice
#12
Angelique L W M M Rops, Erik Jansen, Alie van der Schaaf, Elmar Pieterse, Nils Rother, Julia Hofstra, Henry B P M Dijkman, Anne-Els van de Logt, Jack Wetzels, Johan van der Vlag, Annemiek B van Spriel
Immunoglobulin A (IgA) nephropathy (IgAN), the most common glomerulonephritis worldwide, is characterized by IgA depositions in the kidney. Deficiency of CD37, a leukocyte-specific tetraspanin, leads to spontaneous development of renal pathology resembling IgAN. However, the underlying molecular mechanism has not been resolved. Here we found that CD37 expression on B cells of patients with IgAN was significantly decreased compared to B cells of healthy donors. Circulating interleukin (IL)-6 levels, but not tumor necrosis factor-α or IL-10, were elevated in Cd37-/- mice compared to wild-type mice after lipopolysaccharide treatment...
March 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29549623/tonsillitis-exacerbates-renal-injury-in-iga-nephropathy-through-promoting-th22-cells-chemotaxis
#13
Lu Gan, Mengyuan Zhu, Xiaozhao Li, Chen Chen, Ting Meng, Jiaxi Pu, Huiming Luo, Fengmin Shao, Qiaoling Zhou
BACKGROUND: Tonsillitis can promote the progression of IgA nephropathy (IgAN) by aggravating immunopathologic response. Th22 cell disorder is involved in the pathogenesis of IgAN with tonsillitis. This study was determined to explore the possible mechanism of IgAN with tonsillitis underlying Th22 cell chemotaxis response to the effect of CCL20, CCL22, and CCL27. METHODS: This research was conducted on 65 subjects including 16 healthy controls (HC group), 5 patients with  renal carcinoma (HTC group) and 44 patients with IgAN between 2015 and 2016...
March 16, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29540152/successful-treatment-of-recurrent-immunoglobulin-a-nephropathy-using-steroid-pulse-therapy-plus-tonsillectomy-10-years-after-kidney-transplantation-a-case-presentation
#14
Haruki Katsumata, Izumi Yamamoto, Yo Komatsuzaki, Mayuko Kawabe, Yusuke Okabayashi, Takafumi Yamakawa, Ai Katsuma, Yasuyuki Nakada, Akimitsu Kobayashi, Yudo Tanno, Jun Miki, Hiroki Yamada, Ichiro Ohkido, Nobuo Tsuboi, Hiroyasu Yamamoto, Takashi Yokoo
BACKGROUND: Both prevention and treatment of recurrent immunoglobulin A nephropathy (IgAN) in kidney transplant recipients are important since recurrent IgAN seems to affect long-term graft survival. We present here a case of recurrent IgAN that was successfully treated using steroid pulse therapy plus tonsillectomy 10 years after kidney transplantation. CASE PRESENTATION: A 46-year-old male was admitted for an episode biopsy with a serum creatinine level of 1...
March 14, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29539619/ctla-4-polymorphisms-in-patients-with-iga-nephropathy-correlate-with-proteinuria
#15
Marius Jacob, Kim Ohl, Tannaz Goodarzi, Sigrid Harendza, Thomas Eggermann, Christina Fitzner, Ralf-Dieter Hilgers, Anna Bolte, Jürgen Floege, Thomas Rauen, Klaus Tenbrock
BACKGROUND/AIMS: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and still constitutes one of the most important causes of end-stage renal disease. Abnormal T cell responses may play a role in IgAN pathogenesis. Co-stimulatory molecules such as cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are important for naive T cells to initiate and terminate immune responses. Single nucleotide polymorphisms (SNPs) in the CTLA4 gene locus are associated with several autoimmune diseases...
March 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29529610/glucocorticoids-reduce-aberrant-o-glycosylation-of-iga1-in-iga-nephropathy-patients
#16
Petr Kosztyu, Martin Hill, Jana Jemelkova, Lydie Czernekova, Leona Raskova Kafkova, Miroslav Hruby, Karel Matousovic, Karel Vondrak, Josef Zadrazil, Ivan Sterzl, Jiri Mestecky, Milan Raska
BACKGROUND/AIMS: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonresponding to angiotensin-converting enzyme inhibitors or angiotensin II blockers, corticosteroids are recommended. METHODS: The relationship between the corticosteroid therapy and serum levels of IgA, aberrantly O-glycosylated IgA1, IgA-containing immune complexes and their mesangioproliferative activity was analyzed in IgA nephropathy patients and disease and healthy controls...
March 6, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29529608/clinicopathological-features-to-predict-progression-of-iga-nephropathy-with-mild-proteinuria
#17
Ding Chen, Jian Liu, Shuwei Duan, Pu Chen, Li Tang, Li Zhang, Zhe Feng, Guangyan Cai, Jie Wu, Xiangmei Chen
BACKGROUND/AIMS: In the past, little attention has been paid to patients with IgA nephropathy (IgAN) who had minimal proteinuria upon the onset. The aim of this study was to analyze the clinicopathological features and the prognostic factors in patients with IgA nephropathy. METHODS: Data of patients that had their first renal biopsy in our hospital and were diagnosed with primary IgAN with proteinuria <1 g/d from January 1995 to December 2014 were retrospectively examined...
March 6, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29523019/application-of-sparse-linear-discriminant-analysis-and-elastic-net-for-diagnosis-of-iga-nephropathy-statistical-and-biological-viewpoints
#18
Tahereh Mohammadi Majd, Shiva Kalantari, Hadi Raeisi Shahraki, Mohsen Nafar, Afshin Almasi, Shiva Samavat, Mahmoud Parvin, Amirhossein Hashemian
Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis diagnosed based on renal biopsy. Mesangial IgA deposits along with the proliferation of mesangial cells are the histologic hallmark of IgAN. Non-invasive diagnostic tools may help to prompt diagnosis and therapy. The discovery of potential and reliable urinary biomarkers for diagnosis of IgAN depends on applying robust and suitable models. Applying two multivariate modeling methods on a urine proteomic dataset obtained from IgAN patients, and comparison of the results of these methods were the purpose of this study...
March 10, 2018: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29521297/the-spectrum-of-biopsy-proven-glomerular-disease-in-china-a-systematic-review
#19
REVIEW
Yue Yang, Zheng Zhang, Li Zhuo, Da-Peng Chen, Wen-Ge Li
Background: Chronic kidney disease has become a leading public health concern in China, as it is associated with increased morbidity, mortality, and costs. However, the overall situation regarding common glomerular diseases in China remains unclear. Hence, the aim of this study was to assess the national profile of the common types of glomerulonephritis in China. Methods: We searched Medline, Embase, Cochrane Library, CNKI, SinoMed, VIP, and Wanfang databases for English and Chinese language articles from inception to September 2017...
March 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29520517/initial-treatment-with-pulse-methylprednisolone-followed-by-short-term-prednisolone-and-tonsillectomy-for-childhood-iga-nephropathy
#20
Akifumi Yamada, Shuichiro Fujinaga, Koji Sakuraya, Asanuma Satoshi, Daishi Hirano
BACKGROUND: Although a combination therapy, comprising 2-year high-dose oral prednisolone (PSL), is effective for treating childhood immunoglobulin A nephropathy (IgAN), severe adverse effects and residual proteinuria occur in some patients after the therapy. METHODS: To clarify the efficacy of intravenous pulse methylprednisolone (IVMP; 15-20 mg/kg; maximum 600 mg/day; for 3 consecutive days/week for 3 weeks) followed by short-term reduced-dose PSL (initially 1 mg/kg; maximum 30 mg on alternate days; tapered off within approximately 12 months) and tonsillectomy as an initial treatment, we retrospectively reviewed the clinical courses of 54 consecutive children with IgAN (32 boys; mean age at onset, 12...
March 8, 2018: Clinical and Experimental Nephrology
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