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https://www.readbyqxmd.com/read/29432215/an-update-on-predicting-renal-progression-in-iga-nephropathy
#1
Sean Barbour, Heather Reich
PURPOSE OF REVIEW: Immunoglobulin A (IgA) nephropathy (IgAN) is a heterogeneous disease, and predicting individual patient risk of renal progression is challenging. Recent studies provide new evidence regarding the use of clinical, histologic, and biomarker predictors of renal outcome in IgAN. RECENT FINDINGS: A meta-analysis of clinical trials demonstrated that early change in proteinuria is a valid surrogate outcome measure for longer term decline in renal function, which supports the use of proteinuria to dynamically re-evaluate patient prognosis over time...
February 9, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29428934/campylobacter-rectus-in-the-oral-cavity-correlates-with-proteinuria-in-immunoglobulin-a-nephropathy-patients
#2
Taro Misaki, Shuhei Naka, Kaoruko Wato, Rina Hatakeyama, Yasuyuki Nagasawa, Seigo Ito, Hiroaki Inaba, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano
BACKGROUND: Periodontitis-related pathogens, such as Campylobacter or Treponema species, have recently been shown to be associated with immunoglobulin A nephropathy (IgAN). Some strains of Streptococcus mutans, a major pathogen of dental caries, harbour the cnm gene that encodes a collagen-binding protein (Cnm). This has also been demonstrated to be associated with urinary protein levels in IgAN patients. OBJECTIVES: The purpose of the present study was to analyse the association of IgAN with C...
February 9, 2018: Nephron
https://www.readbyqxmd.com/read/29423199/iga-nephropathy-in-greece-data-from-the-registry-of-the-hellenic-society-of-nephrology
#3
Maria Stangou, Marios Papasotiriou, Dimitrios Xydakis, Theodora Oikonomaki, Smaragdi Marinaki, Synodi Zerbala, Constantinos Stylianou, Pantelitsa Kalliakmani, Aimilios Andrikos, Antonia Papadaki, Olga Balafa, Spyridon Golfinopoulos, Georgios Visvardis, Georgios Moustakas, Evangelos Papachristou, Theodora Kouloukourgiotou, Eleni Kapsia, Angeliki Panagiotou, Constantinos Koulousios, Christos Kavlakoudis, Maria Georgopoulou, Stylianos Panagoutsos, Demetrios V Vlahakos, Theophanis Apostolou, Ioannis Stefanidis, Kostas Siamopoulos, Ioannis Tzanakis, Apostolos Papadogiannakis, Eugene Daphnis, Christos Iatrou, John N Boletis, Aikaterini Papagianni, Dimitrios S Goumenos
Background: Natural history, predisposing factors to an unfavourable outcome and the effect of various therapeutic regimens were evaluated in a cohort of 457 patients with immunoglobulin A nephropathy (IgAN) and follow-up of at least 12 months. Methods: Patients with normal renal function and proteinuria <1 g/24 h as well as those with serum creatinine (SCr) >2.5 mg/dL and/or severe glomerulosclerosis received no treatment. Patients with normal or impaired renal function and proteinuria >1 g/24 h for >6 months received daily oral prednisolone or a 3-day course of intravenous (IV) methylprednisolone followed by oral prednisolone per os every other day or a combination of prednisolone and azathioprine...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423198/micrornas-a-new-avenue-to-understand-investigate-and-treat-immunoglobulin-a-nephropathy
#4
Haresh Selvaskandan, Izabella Pawluczyk, Jonathan Barratt
IgA nephropathy (IgAN) is the most common cause of primary glomerulonephritis worldwide. Up to 30% of cases develop the progressive form of the disease, eventually requiring renal replacement therapy. Diagnosis and risk stratification relies on an invasive kidney biopsy and management options are limited, with recurrence following renal transplantation being common. Thus the quest to understand the pathophysiology of IgAN has been one of great importance. MicroRNAs (miRs) are short nucleotides that suppress gene expression by hybridizing to the 3' untranslated region of messenger RNA (mRNAs), promoting mRNA degradation or disrupting translation...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29417981/immunoexpression-of-iga-receptors-cd89-cd71-in-dermatitis-herpetiformis
#5
Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Monika Bowszyc-Dmochowska, Elżbieta Kaczmarek, Marian Dmochowski
INTRODUCTION: The role of IgA receptors in dermatitis herpetiformis (DH) pathogenesis is still unknown. CD89 and CD71 may be associated with immune response during DH development. The purpose of this study was to perform semiquantitative analysis of simultaneous immunoexpression of CD89 and CD71 in DH and IgA/neutrophil-mediated non-DH dermatoses (IgAN) in relation to specific IgA autoantibodies/antibodies (tissue and epidermal transglutaminases, nonapeptides of gliadin - eTG/tTG/npG) as well neutrophil activation via the release of neutrophil elastase (NE)...
February 8, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29415664/gender-related-differences-in-clinicopathological-characteristics-and-renal-outcomes-of-chinese-patients-with-iga-nephropathy
#6
Wei Deng, Xiaojun Tan, Qian Zhou, Zhen Ai, Wenting Liu, Wei Chen, Xueqing Yu, Qiongqiong Yang
BACKGROUND: The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN. METHODS: This was a single-centre retrospective study. Patients were divided into two groups according to gender. The clinicopathological features at biopsy and renal outcomes during the follow-up were collected and analysed. Renal outcomes were defined as the doubling of baseline serum creatinine and end-stage renal disease (ESRD) (estimated glomerular filtration rate < 15 mL/min/1...
February 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29410298/renal-outcomes-in-primary-iga-nephropathy-patients-with-segmental-glomerular-necrosis-a-case-control-study
#7
Min Pan, Ji Zhang, Xiaohan You, Duo Li, Yinqiu Lv, Jianna Zhang, Xiaokai Ding, Zhanyuan Li, Feifei Xu, Chaosheng Chen
The renal prognosis and treatment of primary IgA nephropathy (IgAN) patients with segmental glomerular necrosis (SGN) remain controversial. Patients with primary IgAN confirmed by renal biopsy were enrolled. Patients with SGN on renal biopsy were selected as the necrosis group, and a propensity score matching method was used to match a control group according to age, gender, weight, height and follow-up time. A total of 825 IgAN patients were enrolled in the present study. Seventy-three (8.8%) patients with SGN were selected as the necrosis group, and 292 patients without SGN were matched as the control group...
February 1, 2018: Human Pathology
https://www.readbyqxmd.com/read/29407303/treatment-of-immunoglobulin-a-nephropathy-recurrence-post-renal-transplant
#8
P S Malhotra, T Jorna, S Bhandari
Immunoglobulin A nephropathy (IgAN) is the most commonly occurring glomerulonephritis. Recurrence of disease in the transplanted kidney can significantly reduce allograft survival rates. Currently, there is no definitive management plan for IgAN recurrence in a transplant that reduces the rate of decline of allograft function and prolongs time to dialysis or re-transplantation. Herein we present a 48-year-old man who had received a renal transplantation in 2006 following his diagnosis of IgAN. In 2015, the patient was noted to have an elevated blood pressure and proteinuria (urinary protein:creatinine ratio [uPCR] 170 mg/mmol)...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29402846/rs1520220-and-rs2195239-polymorphisms-of-igf-1-gene-associated-with-histopathological-grades-in-iga-nephropathy-in-northwestern-chinese-han-population
#9
Linting Wei, Rongguo Fu, Xinghan Liu, Li Wang, Meng Wang, Qiaoling Yu, Tian Tian, Dan Niu, Tianbo Jin, Zhijun Dai, Jie Gao
BACKGROUND/AIMS: Insulin-like growth factor-1 (IGF-1) plays important roles in cellular proliferation, differentiation, and growth. Previous studies showed that single-nucleotide polymorphisms (SNPs) of IGF-1 are associated with various diseases. This case-control study aimed to examine the relationship between IGF-1 polymorphisms and IgA nephropathy (IgAN) risk in a Chinese Han population. METHODS: We recruited 351 IgAN patients and 310 healthy controls from Northwestern China...
January 24, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29395936/a-proposed-oxford-classification-based-clinicopathological-nomogram-for-predicting-short-term-renal-outcomes-in-iga-nephropathy-after-acute-kidney-injury
#10
Ling Zhang, Xiaodong Zhuang, Xinxue Liao
BACKGROUND: This study aimed to investigate the effect of acute kidney injury (AKI) on the progression of renal disease and to develop a clinico-pathological nomogram to predict the renal outcome of IgA nephropathy (IgAN) patients, based on Oxford classification score. METHODS: This is a retrospective observational study. A total of 988 IgAN patients treated at our hospital between 2006 and 2011 were included and divided into AKI (n = 82) and non-AKI group (n = 906)...
January 30, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29395351/end-stage-renal-disease-and-mortality-outcomes-across-different-glomerulonephropathies-in-a-large-diverse-us-population
#11
John J Sim, Simran K Bhandari, Michael Batech, Aviv Hever, Teresa N Harrison, Yu-Hsiang Shu, Dean A Kujubu, Tracy Y Jonelis, Michael H Kanter, Steven J Jacobsen
OBJECTIVE: To compare renal function decline, incident end-stage renal disease (ESRD), and mortality among patients with 5 common glomerular diseases in a large diverse population. PATIENTS AND METHODS: A retrospective cohort study (between January 1, 2000, and December 31, 2011) of patients with glomerulonephropathy using the electronic health record of an integrated health system was performed. Estimated glomerular filtration rate (eGFR) change, incident ESRD, and mortality were compared among patients with biopsy-proven focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MN), minimal change disease (MCD), immunoglobulin A nephropathy (IgAN), and lupus nephritis (LN)...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29393471/expression-of-immunoglobulin-a-in-human-mesangial-cells-and-its-effects-on-cell-apoptosis-and-adhesion
#12
Hui Deng, Junfan Ma, Ziyang Jing, Zhenling Deng, Yaoxian Liang, Lata A, Yang Liu, Xiaoyan Qiu, Yue Wang
IgA nephropathy (IgAN) is characterized by predominant IgA deposition in the glomerular mesangium. It has been considered that the deposited IgA is synthesized by B cells, although recent reports have suggested the implication of other cell types. Therefore, the present study investigated whether glomerular mesangial cells could produce IgA by themselves. Semi‑quantitative reverse transcription-polymerase chain reaction, and immunostaining analysis revealed that the IgA protein and gene transcripts were expressed in primary human renal mesangial cells (HRMCs)...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29374910/-clinical-efficacy-of-tonsillectomy-in-renal-transplant-patients-with-recurrent-iga-nephropathy
#13
L Zhu, H Feng, J D Jia, S Peng, Y Q Li, J F Shao, X F He, Y Guan, H Guo, Z B Lin, G Chen
Objective: To investigate the therapeutic efficacy of tonsillectomy for patients with recurrence of IgA nephropathy (IgAN) after kidney transplantation. Methods: From May 2014, tonsillectomy was performed in 11 renal transplant patients with biopsy-proved recurrent IgAN. In a median follow-up of 14 (4-38) months, data of proteinuria, hematuria, estimated glomerular filtration rate (eGFR), and serum levels of IgA in these patients were compared before and after tonsillectomy.Patient's survival and renal graft survival were also summarized...
January 16, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29345747/recurrent-iga-nephropathy-after-renal-transplantation-and-steroid-withdrawal
#14
Maria Cristina di Vico, Maria Messina, Fabrizio Fop, Antonella Barreca, Giuseppe Paolo Segoloni, Luigi Biancone
Immunoglobulin A Nephropathy (IgAN), is the most common primary glomerulonephritis; the reported recurrence rate of IgAN after renal transplantation is as high as 13-50%. The impact of immunosuppressive therapy and steroid withdrawal on the risk of recurrence of IgAN is still under debate. We performed a retrospective single center study, selecting 123 kidney transplants (rtx) in 120 patients, between January 1995 and December 2012, with IgAN on the native kidney. In 51/123 at least one post transplantation biopsy for clinical indication was performed; in 28/51 transplants IgAN recurrence (IgANr) was demonstrated...
January 18, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29329643/iga-nephropathy-and-iga-vasculitis-with-nephritis-have-a-shared-feature-involving-galactose-deficient-iga1-oriented-pathogenesis
#15
Hitoshi Suzuki, Junichi Yasutake, Yuko Makita, Yuki Tanbo, Kohei Yamasaki, Tadashi Sofue, Toshiki Kano, Yusuke Suzuki
Galactose-deficient IgA1 has been proposed as an important effector molecule in IgA nephropathy (IgAN). We previously showed that the galactose-deficient IgA1-specific monoclonal antibody KM55 can detect circulating galactose-deficient IgA1 in patients with IgAN, enabling us to study the molecular roles of galactose-deficient IgA1. Herein, we further examined the pathophysiological significance of galactose-deficient IgA1 in glomerular deposits of patients with IgAN by immunohistochemistry using KM55. Immunostaining of galactose-deficient IgA1 with KM55 was performed in paraffin-embedded sections of renal biopsy specimens from 48 patients with IgAN and 49 patients with other renal diseases such as lupus nephritis, HCV-related nephropathy, IgA vasculitis with nephritis (IgA-VN), and membranous nephropathy...
January 9, 2018: Kidney International
https://www.readbyqxmd.com/read/29318516/cloning-and-expression-of-h-influenzae-49247-iga-protease-in-e-coli
#16
Honglian Wang, Xia Zhong, Jianchun Li, Menglian Zhu, Lu Wang, Xingli Ji, Junming Fan, Li Wang
IgA protease is secreted by various mucosal pathogenic bacteria which can cleave human immunoglobulin A1 (IgA1) in its hinge region. In addition to be considered as a virulence factor, it's reported that IgA protease can also be used for IgA nephropathy (IgAN) treatment. Our previous study identified bacteria H. influenzae 49247 expressed high activity of IgA protease with promised application in IgAN therapy. In this study, we cloned the IgA protease gene of H. influenzae 49247 with degenerate primers. Alignment analysis indicated that H...
January 9, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29312588/tripterygium-wilfordii-inhibits-tonsillar-iga-production-by-downregulating-iga-class-switching-in-iga-nephropathy
#17
Huining Li, Dan Kong, Yangyang Xu, Xiaomei Li, Guodong Yao, Kexin Chen, Qi You, Qingtao Shi, Lei Zhang, Xin Wang, Dawei Yuan, Shusheng Miao, Jingshu Geng, Xiaoming Jin, Hongxue Meng
IgA nephropathy (IgAN) is characterized by high serum IgA levels and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils, where present enhancement of IgA production by IgA class switching and immuno-activation. Tripterygium Wilfordii (TW) was found to be especially effective in IgAN by its' immunosuppression effect. Given this background, we investigated the mechanisms underlying the role of TW in the generation of IgA and IgA class switching in tonsillar GCs of IgAN patients...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29299950/interleukin-17-promotes-the-production-of-underglycosylated-iga1-in-dakiki-cells
#18
Jia-Ru Lin, Ji Wen, Hui Zhang, Li Wang, Fang-Fang Gou, Man Yang, Jun-Ming Fan
BACKGROUND: Interleukin 17 (IL-17) plays an important role in the pathogenesis of autoimmune diseases and might be associated with IgA nephropathy (IgAN). This study aimed to investigate the effect of IL-17 on autoimmune pathogenesis in IgA nephropathy. METHODS: DAKIKI cells were cultured and stimulated with IL-17 to perform dose-dependent and time-dependent experiments. Cell proliferation was examined by cell counting and the Cell Counting Kit-8 (CCK-8) assay. The IgA concentration and the degree of galactosylation in the supernatant were tested using ELISA and a helix aspersa (HAA) lectin binding assay, respectively...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29245330/a-first-case-report-of-pulmonary-hyalinizing-granuloma-associated-with-immunoglobulin-a-nephropathy
#19
June Hong Ahn, Jee Seon Kim, Joon Hyuk Choi, Jin Hong Chung
RATIONALE: Pulmonary hyalinizing granuloma (PHG) is a rare benign disease that has been shown to be associated with the deposition of immune complexes in the lung parenchyma caused by infection or autoimmune diseases. There have been no reports of PHG in association with immunoglobulin A nephropathy (IgAN). PATIENT CONCERNS: A 30-year-old woman visited with a 12-month history of dyspnea on exertion and cough that had worsened 1 month before her visit. DIAGNOSIS: PHG associated with IgAN...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29240274/complement-factor-h-gene-polymorphism-rs6677604-and-the-risk-severity-and-progression-of-iga-nephropathy-a-systematic-review-and-meta-analysis
#20
See Cheng Yeo, Xinyang Liu, Adrian Liew
BACKGROUND & AIM: Complement activation plays a key role in the pathogenesis of IgA nephropathy (IgAN). Several studies have reported an association between complement factor H gene rs6677604 polymorphism and susceptibility to IgAN; however, attempts at validating this relationship had yielded inconsistent results. We performed a systematic review and meta-analysis to clarify the association between rs6677604 and IgAN susceptibility, disease severity and chronic progression. METHODS: A comprehensive database search was performed to identify eligible studies...
December 14, 2017: Nephrology
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