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Bipolar affective disorder

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https://www.readbyqxmd.com/read/29036385/the-latent-taxonicity-of-schizotypy-in-biological-siblings-of-probands-with-schizophrenia
#1
Richard J Linscott, Sarah E Morton
If schizotypy is a taxonic liability for schizophrenia with a general population prevalence of ~10%, it should also be taxonic among biological siblings of probands with schizophrenia. Moreover, assuming this is so, siblings' schizotypy class membership should be predicted by probands' familial load for psychotic disorder and clinical severity, consistent with a multifactorial polygenic threshold model of schizophrenia. We tested these hypotheses in the Genetic Risk and Outcome of Psychosis (GROUP) Study where siblings of probands (n = 792) and unaffected controls (n = 559) provided self-report ratings on the Community Assessment of Psychic Experiences (CAPE)...
October 4, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29033643/dandy-walker-malformation-presenting-with-affective-symptoms
#2
Mert Batmaz, Zeynep Ezgi Balçik, Ürün Özer, Burcu Hamurişçi Yalçin, Şakir Özen
Dandy-Walker malformation is defined by enlarged posterior fossa, cystic dilatation of the fourth ventricle, and cerebellar hypoplasia. Although developmental delay and mental retardation are common in Dandy-Walker malformation cases, other comorbid psychiatric conditions have been rarely reported. There are limited numbers of case reports about comorbidity of bipolar disorder with Dandy-Walker malformation in the literature. Herein, a Dandy-Walker malformation case presenting affective symptoms is reported, and psychiatric symptoms which might be seen in this rare malformation are discussed along with diagnosis, treatment, and follow-up processes...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29029678/positive-and-negative-affect-as-links-between-social-anxiety-and-depression-predicting-concurrent-and-prospective-mood-symptoms-in-unipolar-and-bipolar-mood-disorders
#3
Jonah N Cohen, M Taylor Dryman, Amanda S Morrison, Kirsten E Gilbert, Richard G Heimberg, June Gruber
The co-occurrence of social anxiety and depression is associated with increased functional impairment and a more severe course of illness. Social anxiety disorder is unique among the anxiety disorders in sharing an affective profile with depression, characterized by low levels of positive affect (PA) and high levels of negative affect (NA). Yet it remains unclear how this shared affective profile contributes to the covariation of social anxiety and depressive symptoms. We examined whether self-reported PA and NA accounted for unique variance in the association between social anxiety and depressive symptoms across three groups (individuals with remitted bipolar disorder, type I [BD; n = 32], individuals with remitted major depressive disorder [MDD; n = 31], and nonpsychiatric controls [n = 30]) at baseline and follow-ups of 6 and 12 months...
November 2017: Behavior Therapy
https://www.readbyqxmd.com/read/29028582/internalized-stigma-and-its-impact-in-indian-outpatients-with-bipolar-disorder
#4
Arghya Pal, Pratap Sharan, Rakesh Kumar Chadda
Patients with many psychiatric disorders have considerable internalized stigma. The current study intended to examine the level and impact of internalized stigma in patients with bipolar affective disorder (BPAD). 60 patients with BPAD, 33 patients with schizophrenia and 30 patients with anxiety disorders were compared on Internalized Stigma of Mental Illness scale and The Stigma Scale. The patients with BPAD were assessed using Rosenberg Self-Esteem Scale (RSES), Participation scale (PS) and World Health Organization Quality Of Life - Brief Version - Hindi (WHOQOL-bref)...
October 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29027157/animal-models-for-bipolar-disorder-from-bedside-to-the-cage
#5
REVIEW
Dominik K E Beyer, Nadja Freund
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense of self, self-esteem, circadian rhythm, cognition, and increased risk for suicide. Effective treatment options are limited and diagnosis can be complicated. To overcome these obstacles, a better understanding of the neurobiology underlying bipolar disorder is needed...
October 13, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29026773/neuroleptic-malignant-syndrome-in-a-patient-with-stable-dose-of-olanzapine
#6
Manoj Kumar Sahoo, Sangita Kamath, Abhijeet Sharan
Neuroleptic malignant syndrome (NMS), a potentially fatal consequence due to typical neuroleptics, has been described so far. In the past few years, there has been increased use of atypical antipsychotic drugs. Cases of NMS related to atypical neuroleptics, such as olanzapine, are less common in spite of increasing cases reported in literatures. Here, we report a case of NMS in a patient with bipolar affective disorder on maintenance treatment with 5 mg olanzapine for the last 7 year. He was successfully treated with bromocriptine and discharged in stable condition in 10 days...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29024194/disrupted-cortico-limbic-connectivity-during-reward-processing-in-remitted-bipolar-i-disorder
#7
Sunny J Dutra, Vincent Man, Hedy Kober, William A Cunningham, June Gruber
OBJECTIVES: Bipolar disorder (BD) is associated with elevated reward sensitivity and persistent positive affect, yet the neural mechanisms underlying these patterns are not well understood. In the present study, we examined putative disruptions in communication within a well-known cortico-limbic reward circuit during reward processing as a potential contributing mechanism to these symptoms. METHODS: The present investigation employed a within- and between-subjects design utilizing a monetary and social incentive delay task among adults with bipolar disorder type I (BD; N = 24) and a healthy non-psychiatric control group (HC; N = 25) during functional magnetic resonance imaging (fMRI)...
October 11, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29022840/irritable-temperament-and-lifetime-psychotic-symptoms-as-predictors-of-anxiety-symptoms-in-bipolar-disorder
#8
Gianluca Serafini, Pierre A Geoffroy, Andrea Aguglia, Giulia Adavastro, Giovanna Canepa, Maurizio Pompili, Mario Amore
PURPOSE: Affective temperaments, hopelessness, alexithymia, and anxiety/agitation symptoms may play a significant role in the psychopathological characteristics of bipolar disorder (BD). Here, we aimed to investigate the eventual association between the mentioned explanatory variables and anxiety/agitation symptoms in BD. MATERIALS AND METHODS: We recruited at the Section of Psychiatry, Department of Neuroscience, University of Genoa (Italy), 92 BD inpatients having a mean age of 52 (±13...
October 12, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29018388/emdr-beyond-ptsd-a-systematic-literature-review
#9
Alicia Valiente-Gómez, Ana Moreno-Alcázar, Devi Treen, Carlos Cedrón, Francesc Colom, Víctor Pérez, Benedikt L Amann
Background: Eye Movement Desensitization and Reprocessing (EMDR) is a psychotherapeutic approach that has demonstrated efficacy in the treatment of Post-traumatic Stress Disorder (PTSD) through several randomized controlled trials (RCT). Solid evidence shows that traumatic events can contribute to the onset of severe mental disorders and can worsen their prognosis. The aim of this systematic review is to summarize the most important findings from RCT conducted in the treatment of comorbid traumatic events in psychosis, bipolar disorder, unipolar depression, anxiety disorders, substance use disorders, and chronic back pain...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28994517/the-impact-of-obesity-on-cognitive-functioning-in-euthymic-bipolar-patients-a-cross-sectional-and-longitudinal-study
#10
Ester Mora, Maria J Portella, Montserrat Martinez-Alonso, Montse Teres, Irene Forcada, Eduard Vieta, Maria Mur
OBJECTIVE: To determine the influence of body mass index (BMI) on cognition in euthymic bipolar patients and healthy matched controls in a post hoc study of 2 cross-sectional and longitudinal exploratory studies. METHOD: A total sample of 121 individuals was examined, which included 52 euthymic bipolar disorder I or II patients (DSM-IV-TR criteria) and 69 healthy controls matched by age and gender, categorized in 2 subgroups in terms of body mass index (BMI-factor): normal weight (BMI: 18...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28992535/quality-of-life-in-schizophrenia-and-bipolar-disorder-the-impact-of-symptomatic-remission-and-resilience
#11
A Hofer, Y Mizuno, F Wartelsteiner, W Wolfgang Fleischhacker, B Frajo-Apor, G Kemmler, M Mimura, S Pardeller, C Sondermann, T Suzuki, A Welte, H Uchida
BACKGROUND: Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients. METHODS: Fifty-two patients with schizophrenia and 60 patients suffering from BD-I from outpatient mental health services as well as 77 healthy control subjects from the general community were included into a cross-sectional study...
September 1, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28988373/lithium-treatment-aggregates-the-adverse-effects-on-erythrocytes-subjected-to-arsenic-exposure
#12
Priti Bhardwaj, Kinnri Jain, Devinder Kumar Dhawan
The present study was designed to investigate the effects of lithium treatment on red blood cells which were given arsenic exposure. Long-term lithium therapy is being extensively used for the treatment of bipolar disorders. Arsenic is a group I carcinogen and a major toxic pollutant in drinking water that affects millions of people worldwide. Male SD rats were segregated into four groups, viz. normal control, lithium treated, arsenic treated, and lithium + arsenic treated. Lithium was supplemented as lithium carbonate at a dose level of 1...
October 7, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28982047/rehospitalization-and-suicide-following-electroconvulsive-therapy-for-bipolar-depression-a-population-based-register-study
#13
Katarzyna Popiolek, Ole Brus, Tove Elvin, Mikael Landén, Johan Lundberg, Pia Nordanskog, Axel Nordenskjöld
BACKGROUND: Electroconvulsive therapy (ECT) is effective in bipolar depression, but relapse is common. The aim of the study was (i) to identify prognostic factors (ii) and to determine the impact of pharmacological approaches on the risk for rehospitalization or suicide. METHODS: This register study analyzed data from individuals treated with inpatient ECT for bipolar depression. Subjects were identified using the Swedish National Patient Register between 2011 and 2014 and the Swedish National Quality Register for ECT...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28973398/neurodevelopmental-disease-associated-de-novo-mutations-and-rare-sequence-variants-affect-trio-gdp-gtp-exchange-factor-activity
#14
Sara M Katrancha, Yi Wu, Minsheng Zhu, Betty A Eipper, Anthony J Koleske, Richard E Mains
Bipolar disorder, schizophrenia, autism, and intellectual disability are complex neurodevelopmental disorders, debilitating millions of people. Therapeutic progress is limited by poor understanding of underlying molecular pathways. Using a targeted search, we identified an enrichment of de novo mutations in the gene encoding the 330-kDa triple functional domain (TRIO) protein associated with neurodevelopmental disorders. By generating multiple TRIO antibodies, we show that the smaller TRIO9 isoform is the major brain protein product, and its levels decrease after birth...
September 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28972123/a-multi-level-functional-study-of-a-snap25-at-risk-variant-for-bipolar-disorder-and-schizophrenia
#15
Josselin Houenou, Jennifer Boisgontier, Annabelle Henrion, Marc-Antoine d'Albis, Anne Dumaine, Julia Linke, Michèle Wessa, Claire Daban, Nora Hamdani, Marine Delavest, Pierre-Michel Llorca, Christophe Lançon, Franck Schürhoff, Andrei Szöke, Philippe Le Corvoisier, Caroline Barau, Cyril Poupon, Bruno Etain, Marion Leboyer, Stéphane Jamain
The synaptosomal associated protein SNAP25 is a key player in synaptic vesicle docking and fusion and has been associated with multiple psychiatric conditions, including schizophrenia, bipolar disorder and attention-deficit/hyperactivity disorder. We recently identified a promoter variant in SNAP25, rs6039769, associated with early-onset bipolar disorder and a higher gene expression level in human prefrontal cortex. In the current study, we showed that this variant was associated both in males and females with schizophrenia in two independent cohorts...
October 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28971006/dysfunctional-gaze-processing-in-bipolar-disorder
#16
Cristina Berchio, Camille Piguet, Christoph M Michel, Paolo Cordera, Tonia A Rihs, Alexandre G Dayer, Jean-Michel Aubry
Gaze conveys emotional information, and humans present sensitivity to its direction from the earliest days of life. Bipolar disorder is a disease characterized by fluctuating states of emotional and cognitive dysregulation. To explore the role of attentional control on face processing in bipolar patients (BP) we used gaze direction as an emotion modulation parameter in a two-back Working Memory (WM) task while high-density EEG data were acquired. Since gaze direction influences emotional attributions to faces with neutral expressions as well, we presented neutral faces with direct and averted gaze...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28968199/meta-analysis-of-central-and-peripheral-%C3%AE-aminobutyric-acid-levels-in-patients-with-unipolar-and-bipolar-depression
#17
Bruno Romeo, Walid Choucha, Philippe Fossati, Jean-Yves Rotge
BACKGROUND: Many studies have measured central and peripheral γ-aminobutyric acid (GABA) levels in patients with depression. We performed a meta-analysis to provide an objective overview of GABA changes in those with unipolar or bipolar depression. METHODS: After a systematic database search, original data were extracted with the help of seminal authors to calculate standardized mean differences. We compared GABA levels between patients with current major depressive episodes and controls, between euthymic patients and controls, and in patients before and after treatment...
October 2, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28966902/mental-health-in-allergic-rhinitis-depression-and-suicidal-behavior
#18
Ameya U Amritwar, Christopher A Lowry, Lisa A Brenner, Andrew J Hoisington, Robert Hamilton, John W Stiller, Teodor T Postolache
A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience...
March 2017: Current Treatment Options in Allergy
https://www.readbyqxmd.com/read/28966598/verbal-memory-impairment-in-patients-with-subsyndromal-bipolar-disorder
#19
Tomiki Sumiyoshi, Atsuhito Toyomaki, Naoko Kawano, Tomoko Kitajima, Ichiro Kusumi, Norio Ozaki, Nakao Iwata, Kazuki Sueyoshi, Kazuyuki Nakagome
BACKGROUNDS: Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28963911/structural-characteristics-of-the-brain-reward-circuit-regions-in-patients-with-bipolar-i-disorder-a-voxel-based-morphometric-study
#20
Junyong Lee, Sunyoung Choi, June Kang, Eunsoo Won, Woo-Suk Tae, Min-Soo Lee, Byung-Joo Ham
Bipolar I disorder (BD-I) is often misdiagnosed, leading to inadequate treatment and significant disability along with reduced quality of life. Recent neural models suggest that the reward circuitry is affected in bipolar disorder. The purpose of the present study was to identify structural abnormalities in the brain reward-processing neural circuitry among patients with BD-I. 21 patients with BD-I and 21 healthy controls (HC) participated in this study. Structural magnetic resonance imaging was performed. Region-of-interest (ROI) voxel-based morphometry analysis was applied to assess the presence of structural changes between the BD-I patient group and the control group...
September 20, 2017: Psychiatry Research
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