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https://www.readbyqxmd.com/read/29930383/comprehensive-in-silico-prediction-of-damage-associated-snps-in-human-prolidase-gene
#1
Richa Bhatnager, Amita S Dang
Prolidase is cytosolic manganese dependent exopeptidase responsible for the catabolism of imido di and tripeptides. Prolidase levels have been associated with a number of diseases such as bipolar disorder, erectile dysfunction and varied cancers. Single nucleotide polymorphism present in coding region of proteins (nsSNPs) has the potential to alter the primary structure as well as function of the protein. Hence, it becomes necessary to differentiate the potential harmful nsSNPs from the neutral ones. 19 nsSNPs were predicted as damaging by in-silico analysis of 298 nsSNPs retrieved from dbSNP database...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29928823/weaning-and-mixed-mania-a-case-report
#2
Verinder Sharma
INTRODUCTION: The development of mania during weaning is an underreported phenomenon that has received little attention in the recent past. Lack of timely diagnosis and effective management can negatively affect not only the mother but also her family. Main issue: I describe the case of a woman who experienced onset of mixed mania during weaning. At that time, she was diagnosed with bipolar I disorder, current episode manic, and a mixed-features specifier. The woman had a history of bipolar II disorder and a family history of postpartum depression and bipolar disorder...
June 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29913768/chronic-non-cancer-pain-and-the-long-term-efficacy-and-safety-of-opioids-some-blind-men-and-an-elephant
#3
C Peter, N Watson
Background The use of opioids for chronic non-cancer pain (CNCP) remains very controversial. There are a number of randomized controlled trials (RCTs) showing efficacy and safety in the short-term, but long-term data are limited. Methods This article contains 10 case reports (followed to 2011) that were selected from a survey of 84 patients with intractable CNCP treated with opioids and followed every 3 months now for a median of 10 years. The previous published survey of this group reported outcomes of pain severity, adverse effects, pain relief, satisfaction, mood, problematic opioid use, tolerance, physical dependency, functional status, health-related quality of life (HRQL), immune status and sexual function...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909818/individual-responses-of-rodents-in-modelling-of-affective-disorders-and-in-their-treatment-prospective-review
#4
Haim Einat, Itamar Ezer, Nirit Z Kara, Catherine Belzung
IntroductionLack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals. RESULTS: Differences between mice strains were studied for some decades now, and sex differences get more attention than in the past...
June 18, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29909301/intrinsic-functional-neurocircuitry-associated-with-treatment-response-to-transdiagnostic-cbt-in-bipolar-disorder-with-anxiety
#5
Kristen K Ellard, Aishwarya G Gosai, Emily E Bernstein, Navneet Kaur, Lousia G Sylvia, Joan A Camprodon, Darin D Dougherty, Andrew A Nierenberg, Thilo Deckersbach
BACKGROUND: Anxiety in bipolar disorder (BD) exacerbates emotion dysregulation and reduces treatment response. We recently conducted a pilot trial of transdiagnostic CBT to target anxiety and emotion dysregulation in BD adjunctive to pharmacotherapy. Reductions in depression and anxiety symptoms were significantly predicted by baseline levels of neuroticism and perceived affective control, as well as changes over time in emotion regulation skills. The present study investigates mechanism of treatment response by examining the relationship between baseline emotion regulation-related neural circuitry and trial outcomes...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29902821/lithium-clinics-in-berlin-and-dresden-a-50-year-experience
#6
Werner Felber, Michael Bauer, Ute Lewitzka, Bruno Müller-Oerlinghausen
Although lithium's serendipitous discovery as a medication for depression dates back more than 200 years, the first scientific evidence that it prevents mania and depression arose only in the 1960s. However, at that time there was a lack of knowledge about how to administer and monitor lithium therapy safely and properly. The lithium clinics in Dresden and Berlin were remarkably similar in their beginnings in the late 1960s regarding patient numbers and scientific expertise without being aware of one another due to the Iron Curtain separating Germany into a western and eastern part until 1990...
June 14, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29888231/exon-array-biomarkers-for-the-differential-diagnosis-of-schizophrenia-and-bipolar-disorder
#7
Marquis Philip Vawter, Robert Philibert, Brandi Rollins, Patricia L Ruppel, Terry W Osborn
This study developed potential blood-based biomarker tests for diagnosing and differentiating schizophrenia (SZ), bipolar disorder type I (BD), and normal control (NC) subjects using mRNA gene expression signatures. A total of 90 subjects ( n = 30 each for the three groups of subjects) provided blood samples at two visits. The Affymetrix exon microarray was used to profile the expression of over 1.4 million probesets. We selected potential biomarker panels using the temporal stability of the probesets and also back-tested them at two different visits for each subject...
May 2018: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29888167/chronotype-and-psychiatric-disorders
#8
REVIEW
Liia Kivelä, Marinos Rodolfos Papadopoulos, Niki Antypa
Purpose of Review: Chronotype, reflecting interindividual differences in daily activity patterns and sleep-wake cycles, is intrinsically connected with well-being. Research indicates increased risk of many adverse mental health outcomes for evening-type individuals. Here, we provide an overview of the current evidence available on the relationship between chronotype and psychiatric disorders. Recent Findings: The association between eveningness and depression is well established cross-sectionally, with preliminary support from longitudinal studies...
2018: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/29884960/metallomics-applied-to-the-study-of-neurodegenerative-and-mental-diseases
#9
Alessandra Sussulini, Rachel Ann Hauser-Davis
Biochemical imbalances, provoked by aging or a secondary illness, might directly affect the brain, causing severe problems, such as loss of memory or alteration of behavior patterns. Brain disorders are usually classified as injuries (such as stroke, hematomas, and concussions), tumors, and neurodegenerative (such as Parkinson's and Alzheimer's diseases) and mental (such as depression, bipolar disorder, schizophrenia) diseases. As the pathophysiology of these illnesses is not completely established and multiple factors are involved, metallomics, a bioanalytical strategy that allows the detection of metal ions and metalloproteins in diverse biological matrices, is of extreme relevance in identifying which elements are affected by a disease and/or treatment...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29881339/new-protocol-for-quantitative-analysis-of-brain-cortex-electroencephalographic-activity-in-patients-with-psychiatric-disorders
#10
Grzegorz M Wojcik, Jolanta Masiak, Andrzej Kawiak, Piotr Schneider, Lukasz Kwasniewicz, Nikodem Polak, Anna Gajos-Balinska
The interview is still the main and most important tool in psychiatrist's work. The neuroimaging methods such as CT or MRI are widely used in other fields of medicine, for instance neurology. However, psychiatry lacks effective quantitative methods to support of diagnosis. A novel neuroinformatic approach to help clinical patients by means of electroencephalographic technology in order to build foundations for finding neurophysiological biomarkers of psychiatric disorders is proposed. A cohort of 30 right-handed patients (21 males, 9 females) with psychiatric disorders (mainly with panic and anxiety disorder, Asperger syndrome as well as with phobic anxiety disorders, schizophrenia, bipolar affective disorder, obsessive-compulsive disorder, nonorganic hypersomnia, and moderate depressive episode) were examined using the dense array EEG amplifier in the P300 experiment...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29880069/effects-of-erythropoietin-on-body-composition-and-fat-glucose-metabolism-in-patients-with-affective-disorders
#11
Maj Vinberg, Pernille Højman, Bente Klarlund Pedersen, Lars Vedel Kessing, Kamilla W Miskowiak
BACKGROUND: Erythropoietin (EPO) has been suggested to improve metabolism and also cognition, but human studies are scarce. This randomised controlled trial aimed to investigate whether EPO treatment influences body composition and fat and glycated haemoglobin (HbA1c) and fasting glucose, and whether these changes would be associated with previous observed cognitive benefits of EPO. METHOD: In total, 84 non-obese patients with treatment-resistant unipolar depression or bipolar disorder in remission were randomised to 8 weekly EPO (40,000 IU) or saline (NaCl 0...
June 8, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29875708/psychological-distress-symptoms-associated-with-life-events-in-patients-with-bipolar-disorder-a-cross-sectional-study
#12
Aiko Sato, Tasuku Hashimoto, Atsushi Kimura, Tomihisa Niitsu, Masaomi Iyo
Stressful life events, although less serious than traumatic experiences, affect the clinical course of patients with bipolar disorder. We previously found that bipolarity in patients with major depression is related to the severity of psychological distress symptoms associated with onset-related events. Here, we investigated whether, and to what extent, bipolar patients perceive stressful events as psychological distress symptoms, specifically, intrusion, avoidance, and hyperarousal. Further, we investigated the relationship between the clinical features and the severity of psychological distress symptoms associated with stressful life events, according to mood states...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29875527/neuropsychological-functioning-in-euthymic-phase-of-bipolar-affective-disorder
#13
Priyanka Bhatia, Ajeet Sidana, Subhash Das, Manoj Kumar Bajaj
Background: A substantial proportion of euthymic bipolar disorder patients have neuropsychological impairment which can have a significant impact on the overall functional recovery. Materials and Methods: A total of 60 bipolar disorder patients, currently in euthymic phase for the last 3 months with minimum duration of illness 2 years and current Young Mania Rating Scale <7 and Hamilton Depression Rating Scale <6, currently on medications were administrated various neuropsychological tests...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29875526/managing-bipolar-affective-disorder-in-a-tribal-district-of-odisha
#14
Dheeraj Kattula, Jayaprakash Russell Ravan, Munaf Babajan Nandyal
Background: Managing any chronic illness in marginalized communities in resource-poor settings is always a challenge. Lack of facility to monitor lithium and the common morbidity of hypokalemic periodic paralysis and chronic renal failure among tribals of northern part of Odisha pose unique challenges in managing bipolar disorder. Methodology: This is a cross-sectional study done in a district-level hospital catering to predominantly tribal population. A part of the data was collected by a psychiatrist prospectively and analyzed...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29873955/risk-factors-associated-with-antidepressant-exposure-and-history-of-antidepressant-induced-mania-in-bipolar-disorder
#15
Aislinn J Williams, Zongshan Lai, Seth Knight, Masoud Kamali, Shervin Assari, Melvin G McInnis
OBJECTIVE: Despite their widespread use in bipolar disorder, there is controversy surrounding the inclusion of antidepressant medications in the disorder's management. We sought to identify which demographic, socioeconomic, and clinical factors are associated with antidepressant exposure in bipolar disorder and which bipolar disorder patients are most likely to report a history of antidepressant-induced mania (AIM) when exposed to antidepressants. METHODS: Our study included subjects with bipolar I disorder (n = 309), bipolar II disorder (n = 66), and bipolar disorder not otherwise specified (n = 27) and schizoaffective disorder, bipolar type (n = 14), from a longitudinal, community-based study...
May 15, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29864713/factors-associated-with-false-positives-in-mdq-screening-for-bipolar-disorder-insight-into-the-construct-validity-of-the-scale
#16
Sabrina Paterniti, Jean-Claude Bisserbe
BACKGROUND: Identifying bipolar patients in the first phases of the illness is essential to establish adequate treatment. The goal of this study was to examine the discriminant ability of the Mood Disorders Questionnaire (MDQ) in recognizing bipolar patients referred to a tertiary care structure. METHODS: Between 2006 and 2012, we assessed 843 individuals referred to the Mood Disorders Program by family physicians in the community. The Structured Clinical Interview for DSM-IV-TR (SCID) was used to assess diagnoses...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29863689/-psychopathology-and-phenomenology-of-religious-delusion-of-possession-in-schizophrenia
#17
G I Kopeyko, O A Borisova, E V Gedevani
AIM: To analyze psychopathological features of religious delusion of possession, determine the place of this phenomenon in psychotic syndrome, and identify the prognosis and dynamics of schizophrenia due to this disorder. MATERIAL AND METHODS: Thirteen patients with religious delusion of possession were examined in 1994-2016 by psychopathological and follow-up methods. RESULTS AND CONCLUSION: Hallucinations of a general feeling are the crucial psychopathological phenomenon of states with religious delusion of possession...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29862493/characteristics-of-depressive-and-bipolar-disorder-patients-with-mixed-features
#18
L Tondo, G H Vázquez, M Pinna, P A Vaccotto, R J Baldessarini
OBJECTIVE: To assess differences between subjects with vs. without mixed features in major affective disorders. METHODS: In 3099 out-patient subjects with DSM-5 major depressive disorder (MDD, n = 1921) or bipolar disorders (BD, n = 1178), we compared those with (Mx) vs. without (Non-Mx) mixed features (agitated-irritable depression or dysphoric [hypo]mania) in an index episode. RESULTS: Prevalence of Mx averaged 21.9% [CI: 20.5-23.4] overall, ranking: BD-II > BD-I > MDD, and in BD depression ≥ [hypo]mania > MDD...
June 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29852049/association-of-idiopathic-sudden-sensorineural-hearing-loss-with-affective-disorders
#19
Jong-Yeup Kim, Jong Won Lee, Myoungsuk Kim, Min Jae Kim, Dong-Kyu Kim
Importance: Patients with idiopathic sudden sensorineural hearing loss (ISSNHL) often experience permanent hearing impairment, which could result in psychological perturbations. However, the relationship between ISSNHL and affective disorders, including depression, anxiety, and bipolar disorder, has not been fully evaluated. Objective: To investigate the potential relationship between ISSNHL and affective disorders using nationwide representative cohort sample data...
May 31, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29850349/treatment-emergent-mania-in-a-prepubertal-boy
#20
Dulangi Maneksha Amerasinghe Dahanayake, Gampolage Swarna Wijetunge
Bipolar disorder among children has gained acceptance as a diagnostic entity but continues to pose diagnostic and management challenges due to the developmental differences in children and inadequate evidence for pharmacological management. We present the case of a prepubertal child presenting with an apparent depressive episode who developed treatment-emergent mania when commenced on sertraline. This case highlights the need for further research into the presentations and pharmacological management of prepubertal children with bipolar affective disorder...
2018: Case Reports in Psychiatry
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