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Affective instability

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https://www.readbyqxmd.com/read/27930791/computational-biomechanical-analysis-of-asymmetric-ectasia-risk-in-unilateral-post-lasik-ectasia
#1
Ali Vahdati, Ibrahim Seven, Naveen Mysore, J Bradley Randleman, William J Dupps
PURPOSE: To develop a computational approach to corneal biomechanical risk analysis in refractive surgery and to investigate its utility in an enigmatic case of unilateral ectasia after bilateral LASIK. METHODS: Preoperative corneal elevation datasets from both eyes of a patient who developed unilateral post-LASIK ectasia were used to construct geometrically patient-specific, microstructurally motivated finite element models. Models were assessed before and after implementation of case-specific treatment parameters for interocular differences in corneal geometry and strain behavior under physiological loading conditions...
December 1, 2016: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/27930445/motion-and-muscle-activity-are-affected-by-instability-location-during-a-squat-exercise
#2
Brian C Nairn, Chad A Sutherland, Janessa D M Drake
Squat exercise training using instability devices have become increasingly popular for a multitude of reasons. Many devices generate instability at the feet and provide a bottom-up perturbation; however, the effect of a top-down instability device during a squat remains unclear. In order to induce instability at the upper body, a water-filled cylinder called the Attitube® was used. This study analyzed the effects of instability location (top-down, bottom-up, no instability) during a squat exercise in terms of kinematics and muscle activation...
November 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27921087/acute-and-chronic-effects-of-gold-nanoparticles-on-sperm-parameters-and-chromatin-structure-in-mice
#3
Mahsa Nazar, Ali Reza Talebi, Mohammad Hosseini Sharifabad, Abolghasem Abbasi, Arezoo Khoradmehr, Amir Hossein Danafar
BACKGROUND: The particles in the range of 1-100 nm are called nanoparticles. Gold nanoparticle is one of the most important metal nanoparticles with wide usage. OBJECTIVE: This study investigated the effects of gold nanoparticles on sperm parameters and chromatin structure in mice. MATERIALS AND METHODS: In this experimental study, 72 male bulb-c mice were divided into 9 groups including: 4 Sham groups (Sc 1-4), 4 experimental groups (Au 1-4), and 1 control group (C)...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27920299/the-type-iii-secretion-system-effector-sptp-of-salmonella-enterica-serovar-typhi
#4
Rebecca Johnson, Alexander Byrne, Cedric N Berger, Elizabeth Klemm, Valerie F Crepin, Gordon Dougan, Gad Frankel
: Salmonella enterica serovars causes gastroenteritis or typhoid fever in humans, with virulence depending on the action of two type III secretion systems (SPI-1 and SPI-2). SptP is a Salmonella SPI-1 effector, involved in mediating recovery of the host cytoskeleton post-infection. SptP requires a chaperone, SicP, for stability and secretion. SptP has 94% identity between S Typhimurium and S Typhi; direct comparison of the protein sequences revealed that S Typhi SptP has numerous amino acid changes within its chaperone-binding domain...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27920260/how-to-deal-with-anterior-knee-pain-in-the-active-young-patient
#5
Vicente Sanchis-Alfonso, Scott F Dye
CONTEXT: Anterior knee pain (AKP) represents the most common reason to consult with a clinician who specializes in the knee. Despite the high incidence of the disorder, however, its etiology is still controversial. Many unnecessary surgeries that may damage the patient are done for this clinical entity. EVIDENCE ACQUISITION: A PubMed search from 1995 through June 2016. STUDY DESIGN: Clinical review. LEVEL OF EVIDENCE: Level 4...
December 5, 2016: Sports Health
https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#6
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27916577/association-of-fibrosis-in-the-infrapatellar-fat-pad-and-degenerative-cartilage-change-of-patellofemoral-joint-after-anterior-cruciate-ligament-reconstruction
#7
Kyoung Ho Yoon, Dae Hyun Tak, Taeg Su Ko, Sang Eon Park, Juhyun Nam, Sang Hak Lee
BACKGROUND: The purpose of this study was to evaluate the prevalence and risk factor of cartilage degeneration of the patellofemoral joint (PFJ) that was diagnosed by second-look arthroscopy. METHODS: One-hundred and seven patients who underwent ACL reconstruction were evaluated by preoperative MRI, postoperative MRI and second-look arthroscopy. Severity of infrapatellar fat pad (IPFP) fibrosis was evaluated by MRI at an average of 26months after ACL reconstruction...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27913416/mutagenesis-of-nosm-leader-peptide-reveals-important-elements-in-nosiheptide-biosynthesis
#8
Liang Jin, Xuri Wu, Yanjiu Xue, Yue Jin, Shuzhen Wang, Yijun Chen
: Nosiheptide, a typical member of ribosomally synthesized and post-translationally modified peptides (RiPPs), exhibits potent activity against multi-drug resistant Gram-positive bacterial pathogens. The precursor peptide of nosiheptide (NosM) is comprised of a leader peptide with 37 amino acids and a core peptide containing 13 amino acids. To pinpoint essential elements in the leader peptide for nosithpetide biosynthesis, a collection of mutants with unique sequence features, including N- and C-terminal motifs, peptide length as well as specific sites in the leader peptide, was generated by mutagenesis in vivo The effects of various mutants on nosiheptide biosynthesis were evaluated...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27910691/compact-ecei-system-with-in-vessel-reflective-optics-for-west
#9
Y B Nam, H K Park, W Lee, G S Yun, M Kim, R Sabot, D Elbeze, P Lotte, J Shen
An electron cyclotron emission imaging (ECEI) diagnostic system for WEST (W Environment for Steady state Tokamak) is under development to study the MHD instabilities affected by tungsten impurities. The system will provide 2-D Te fluctuation images (width × height = ∼18 cm × ∼ 34 cm at low field side and ∼13 cm × ∼ 39 cm at high field side) from a poloidal cross section with high spatial (≤1.7 cm) and temporal (≤2 μs) resolutions. While the key concept and electronic structure are similar to that of prior ECEI systems on other tokamak devices such as KSTAR, DIII-D, or ASDEX-U, part of the imaging optics have to be placed inside the vacuum vessel in order to resolve issues on limited installation space and longer beam path to the detector position...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910528/compact-and-multi-view-solid-state-neutral-particle-analyzer-arrays-on-national-spherical-torus-experiment-upgrade
#10
D Liu, W W Heidbrink, K Tritz, E D Fredrickson, G Z Hao, Y B Zhu
A compact and multi-view solid state neutral particle analyzer (SSNPA) diagnostic based on silicon photodiode arrays has been successfully tested on the National Spherical Torus Experiment-Upgrade. The SSNPA diagnostic provides spatially, temporally, and pitch-angle resolved measurements of fast-ion distribution by detecting fast neutral flux resulting from the charge exchange (CX) reactions. The system consists of three 16-channel subsystems: t-SSNPA viewing the plasma mid-radius and neutral beam (NB) line #2 tangentially, r-SSNPA viewing the plasma core and NB line #1 radially, and p-SSNPA with no intersection with any NB lines...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908898/clinically-useful-screen-for-borderline-personality-disorder-in-psychiatric-out-patients
#11
Mark Zimmerman, Matthew D Multach, Kristy Dalrymple, Iwona Chelminski
A total of 3674 psychiatric out-patients were evaluated with a semi-structured diagnostic interview for DSM-IV borderline personality disorder (BPD). The affective instability criterion had a sensitivity of 92.8%, higher than the sensitivities of the other eight BPD criteria. The negative predictive value of the affective instability criterion was 99%. We recommend that clinicians screen for BPD in the same way that they screen for other psychiatric disorders: by enquiring about a single feature of the disorder (i...
December 1, 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27908234/sustained-early-disruption-of-mitochondrial-function-contributes-to-arsenic-induced-prostate-tumorigenesis
#12
B Singh, M Kulawiec, K M Owens, A Singh, K K Singh
Arsenic is a well-known human carcinogen that affects millions of people worldwide, but the underlying mechanisms of carcinogenesis are unclear. Several epidemiological studies have suggested increased prostate cancer incidence and mortality due to exposure to arsenic. Due to lack of an animal model of arsenic-induced carcinogenesis, we used a prostate epithelial cell culture model to identify a role for mitochondria in arsenic-induced prostate cancer. Mitochondrial morphology and membrane potential was impacted within a few hours of arsenic exposure of non-neoplastic prostate epithelial cells...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27908012/pt-symmetric-couplers-with-competing-cubic-quintic-nonlinearities
#13
Gennadiy Burlak, Salomon Garcia-Paredes, Boris A Malomed
We introduce a one-dimensional model of the parity-time ( PT)-symmetric coupler, with mutually balanced linear gain and loss acting in the two cores, and nonlinearity represented by the combination of self-focusing cubic and defocusing quintic terms in each core. The system may be realized in optical waveguides, in the spatial and temporal domains alike. Stationary solutions for PT-symmetric solitons in the systems are tantamount to their counterparts in the ordinary coupler with the cubic-quintic nonlinearity, where the spontaneous symmetry breaking of solitons is accounted for by bifurcation loops...
November 2016: Chaos
https://www.readbyqxmd.com/read/27905359/-clinical-and-neuropsychological-features-of-alzheimer-s-disease-in-the-combination-with-cerebrovascular-disease
#14
N A Trusova, O S Levin, A V Arablinsky
AIM: To study clinical/neuropsychological and neuroimaging characteristics of Alzheimer's disease in the combination with cerebrovascular disease (CVD). MATERIAL AND METHODS: Ninety patients with dementia, including 35 patients with AD, 35 patients with mixed dementia (MD) and 20 patients with vascular dementia, were examined. The character of dementia was established according to NINCDS-ADRDA and NINDS-AIREN criteria. The neuropsychological battery included Addenbrooke's Cognitive Examination (ACE-R), Montreal Cognitive Assessment scale (MoCA), fluency test and the visual memory test (SCT)...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27904918/-diagnosis-and-treatment-of-the-watering-eye
#15
M Schargus, G Geerling
The wet eye is a common symptom that ophthalmologists as well as otorhinolaryngolists are confronted with. The causes can be diverse, affecting all parts from the lacrimal gland to the lacrimal drainage system. Frequently tear film changes are the reason for the symptoms, which may vary from classic epiphora and impaired vision to tear film instability with damage of the corneal epithelium. The knowledge and understanding of the underlying pathologies and differential diagnosis is crucial in order to initiate adequate therapy and to avoid overtreating with invasive surgical means...
November 30, 2016: HNO
https://www.readbyqxmd.com/read/27904758/penetrating-thoracic-spinal-cord-injury-with-ice-pick-extending-into-the-aorta-a-technical-note-and-review-of-the-literature
#16
Rani Nasser, Jonathan Nakhla, Saadat Sharif, Merritt Kinon, Reza Yassari
BACKGROUND: Penetrating spinal cord injuries pose a great challenge to both patients and the treating physicians. Although the overall incidence of penetrating spinal cord injury is the highest in the military, the ubiquity of guns in our society continues to make penetrating spinal cord injury prevalent in the civilian population. These types of injuries are particularly complicated because, beyond the trauma to the neural elements and supporting structures, other organs can be affected and a team approach is required for successful treatment...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27904235/management-of-acute-work-related-shoulder-injuries-by-an-early-shoulder-assessment-program-efficiency-of-imaging-investigations
#17
Helen Razmjou, Sandra Lincoln, Christopher Geddes, Dragana Boljanovic, Iona Macritchie, Caterina Virdo-Cristello, Danielle Medeiros, Robin R Richards
Purpose: There has been a significant increase in the number of costly investigations of the shoulder joint over the past decade. The purposes of this study were to (1) describe the diagnostic imaging investigations ordered for injured workers seen at an Early Shoulder Physician Assessment (ESPA) program, (2) evaluate the impact of these investigations on final diagnosis and management, and (3) examine how efficient the program was by determining the appropriateness of referrals and whether costly imaging was justified...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27902841/dynamical-effects-of-calcium-sensitive-potassium-currents-on-voltage-and-calcium-alternans
#18
Matthew Kennedy, Donald M Bers, Nipavan Chiamvimonvat, Daisuke Sato
Cardiac alternans is a precursor to life-threatening arrhythmias. Alternans can be caused by instability of the membrane voltage (Vm ), instability of the intracellular Ca (Cai ) cycling, or both. Vm dynamics and Cai dynamics are coupled via Ca-sensitive currents. In cardiac myocytes, there are several Ca-sensitive potassium (K) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca-activated potassium (SK) current (ISK ). However, the role of these currents in the development of arrhythmias is not well understood...
November 30, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27899802/genomic-and-transcriptional-landscape-of-p2ry8-crlf2-positive-childhood-acute-lymphoblastic-leukemia
#19
C Vesely, C Frech, C Eckert, G Cario, A Mecklenbräuker, U Zur Stadt, K Nebral, F Kraler, S Fischer, A Attarbaschi, M Schuster, C Bock, H Cavé, A von Stackelberg, M Schrappe, M A Horstmann, G Mann, O A Haas, R Panzer-Grümayer
Children with P2RY8-CRLF2-positive ALL have an increased relapse risk. Their mutational and transcriptional landscape as well as the respective patterns at relapse remains largely elusive. We therefore performed an integrated analysis of whole-exome and RNA-sequencing in 41 major clone fusion-positive cases including 19 matched diagnosis/relapse pairs. We detected a variety of frequently subclonal and highly instable JAK/STAT but also RTK/Ras pathway activating mutations in 76% of cases at diagnosis and virtually all relapses...
November 30, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27899194/strategies-for-clinical-implementation-of-screening-for-hereditary-cancer-syndromes
#20
REVIEW
Brandie Heald, Jessica Marquard, Pauline Funchain
Hereditary cancer syndromes generally account for 5%-10% of malignancies. While these syndromes are rare, affected patients carry significantly elevated risks of developing cancer, as do their at-risk relatives. Identification of these patients is critical to ensure timely and appropriate genetic testing relevant to cancer patients and their relatives. Several guidelines and tools are available to assist clinicians. Patients suspected to have hereditary cancer syndromes should be offered genetic testing in the setting of genetic counseling by a qualified genetics professional...
October 2016: Seminars in Oncology
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