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Affective instability

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https://www.readbyqxmd.com/read/29343857/stimulation-of-epicardial-sympathetic-nerves-at-different-sites-induces-cardiac-electrical-instability-to-various-degrees
#1
Liang Wang, Lin Sun, Kun Wang, Yingying Jin, Qing Liu, Zhongnan Xia, Xudong Liu, Jiakun Zhang, Jingjie Li
The cardiac sympathetic nerves distribute across cardiac tissues with uneven density. Yet, to what extent this anatomical heterogeneity affects electrical activity of the left ventricle is largely unknown. Dogs were randomized into non-stimulation control (NC), posterior basal-stimulation (PB), anterior superior-stimulation (AS), apical part-stimulation (AP) group. The epicardial sympathetic nerves at different sites along their distribution were with electrical stimulation (ES) for 4 hours except in the NC group...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29341797/visual-dependence-affects-postural-sway-responses-to-continuous-visual-field-motion-in-individuals-with-cerebral-palsy
#2
Yawen Yu, Richard T Lauer, Carole A Tucker, Elizabeth D Thompson, Emily A Keshner
The current study aimed to explore the impact of visual dependence on sensorimotor coupling of postural sway and visual motion in adults and teens with spastic cerebral palsy (CP). We hypothesized that individuals with CP would exhibit greater magnitudes of sway than healthy individuals, and the presence of visual dependence (VD) would produce instability in the direction of visual motion. Participants stood in a virtual environment in which the visual scene remained static or continuously rotated 30 degree/second in pitch-up or pitch-down...
January 17, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29341696/coherent-beam-beam-instability-in-collisions-with-a-large-crossing-angle
#3
K Ohmi, N Kuroo, K Oide, D Zhou, F Zimmermann
In recent years the "crab-waist collision" scheme [P. Raimondi, Proceedings of 2nd SuperB Workshop, Frascati, 2006.; M. Zobov et al., Phys. Rev. Lett. 104, 174801 (2010)PRLTAO0031-900710.1103/PhysRevLett.104.174801] has become popular for circular e^{+} e^{-} colliders. The designs of several future colliders are based on this scheme. So far the beam-beam effects for collisions under a large crossing angle with or without crab waist were mostly studied using weak-strong simulations. We present here strong-strong simulations showing a novel strong coherent head-tail instability, which can limit the performance of proposed future colliders...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341674/stochastic-and-resolvable-gravitational-waves-from-ultralight-bosons
#4
Richard Brito, Shrobana Ghosh, Enrico Barausse, Emanuele Berti, Vitor Cardoso, Irina Dvorkin, Antoine Klein, Paolo Pani
Ultralight scalar fields around spinning black holes can trigger superradiant instabilities, forming a long-lived bosonic condensate outside the horizon. We use numerical solutions of the perturbed field equations and astrophysical models of massive and stellar-mass black hole populations to compute, for the first time, the stochastic gravitational-wave background from these sources. In optimistic scenarios the background is observable by Advanced LIGO and LISA for field masses m_{s} in the range ∼[2×10^{-13},10^{-12}] and ∼5×[10^{-19},10^{-16}]  eV, respectively, and it can affect the detectability of resolvable sources...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29339848/habitual-patellar-dislocation-in-children-results-of-surgical-treatment-by-modified-four-in-one-technique
#5
Ravi Mittal, Avtar Singh Balawat, Vikrant Manhas, Amit Roy, Navin Kumar Singh
Background: Habitual patellar dislocation is a rare condition affecting children. The growth plates are open in children and any surgical intervention should take that in to consideration. We are describing a modified four in one technique for habitual patellar dislocation, which is a soft tissue procedure without the use of any implant. Method: In this study we included 6 children (4 females and 2 males) with open growth plates, which were diagnosed with habitual patellar dislocation...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29339483/hells-and-cdca7-comprise-a-bipartite-nucleosome-remodeling-complex-defective-in-icf-syndrome
#6
Christopher Jenness, Simona Giunta, Manuel M Müller, Hiroshi Kimura, Tom W Muir, Hironori Funabiki
Mutations in CDCA7, the SNF2 family protein HELLS (LSH), or the DNA methyltransferase DNMT3b cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. While it has been speculated that DNA methylation defects cause this disease, little is known about the molecular function of CDCA7 and its functional relationship to HELLS and DNMT3b. Systematic analysis of how the cell cycle, H3K9 methylation, and the mitotic kinase Aurora B affect proteomic profiles of chromatin in Xenopus egg extracts revealed that HELLS and CDCA7 form a stoichiometric complex on chromatin, in a manner sensitive to Aurora B...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29338912/-surgical-outcomes-of-traumatic-cervical-fractures-in-patients-with-ankylosing-spondylitis
#7
Alberto Isla Guerrero, Beatriz Mansilla Fernández, Borja Hernández Garcia, Álvaro Gómez de la Riva, María Luisa Gandía González, Elena Isla Paredes
OBJECTIVE: Ankylosing spondylitis is an inflammatory rheumatic disease mainly affecting the axial skeleton. The rigid spine may secondarily develop osteoporosis, further increasing the risk of spinal fracture. In this study, we reviewed fractures in patients with ankylosing spondylitis that had been clinically diagnosed to better define the mechanism of injury, associated neurological deficit, predisposing factors, and management strategies. METHODS: Between January 2004 and December 2014, 6 patients with ankylosing spondylitis and neurological complications after injuries were treated...
January 12, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29338072/targeting-her2-in-colorectal-cancer-the-landscape-of-amplification-and-short-variant-mutations-in-erbb2-and-erbb3
#8
Jeffrey S Ross, Marwan Fakih, Siraj M Ali, Julia A Elvin, Alexa B Schrock, James Suh, Jo-Anne Vergilio, Shakti Ramkissoon, Eric Severson, Sugganth Daniel, David Fabrizio, Garrett Frampton, James Sun, Vincent A Miller, Philip J Stephens, Laurie M Gay
BACKGROUND: In contrast to lung cancer, few precision treatments are available for colorectal cancer (CRC). One rapidly emerging treatment target in CRC is ERBB2 (human epidermal growth factor receptor 2 [HER2]). Oncogenic alterations in HER2, or its dimerization partner HER3, can underlie sensitivity to HER2-targeted therapies. METHODS: In this study, 8887 CRC cases were evaluated by comprehensive genomic profiling for genomic alterations in 315 cancer-related genes, tumor mutational burden, and microsatellite instability...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29336567/non-isothermal-spreading-dynamics-of-self-rewetting-droplets
#9
Dimitrios Mamalis, Vasileios Koutsos, Khellil Sefiane
We experimentally studied the spreading dynamics of binary alcohol mixtures (and pure liquids for reference) deposited on a heated substrate in a partially wetting situation, under non-isothermal conditions. We show that the spreading mechanism of an evaporating droplet exhibits a power law growth with early-stage exponents that depend strongly and non-monotonically on substrate temperature. Moreover, we investigated the temporal and spatial thermal dynamics in the droplet using infrared thermography revealing the existence of unique thermal patterns due to thermal and/or solutal instabilities which lead to surface tension gradients, namely Marangoni effect...
January 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29331781/a-step-wise-self-assembly-approach-in-preparation-of-multi-responsive-poly-styrene-co-methyl-methacrylate-nanoparticles-containing-spiropyran
#10
Fahimeh Khakzad, Ali Reza Mahdavian, Hamid Salehi-Mobarakeh, Mohammad Hossain Sharifian
HYPOTHESIS: Surfactant-free emulsion polymerization has become favorable due to circumventing instability issues reasonably. Incorporation of an appropriate hydrophilic macroRAFT, could provide controlled in-situ self-assembly via copolymerization with hydrophobic monomers into polymer particles. So far, this approach has mostly been studied in dispersion systems and further studies are needed in emulsions. Beside the corresponding mechanistic studies, the prepared latex particles would potentially exhibit smart behaviors by choosing stimuli-responsive monomers...
January 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331064/controlling-the-temporal-structure-of-brain-oscillations-by-focused-attention-meditation
#11
Mona Irrmischer, Simon J Houtman, Huibert D Mansvelder, Michael Tremmel, Ulrich Ott, Klaus Linkenkaer-Hansen
Our focus of attention naturally fluctuates between different sources of information even when we desire to focus on a single object. Focused attention (FA) meditation is associated with greater control over this process, yet the neuronal mechanisms underlying this ability are not entirely understood. Here, we hypothesize that the capacity of attention to transiently focus and swiftly change relates to the critical dynamics emerging when neuronal systems balance at a point of instability between order and disorder...
January 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29329947/-pseudoexfoliation-syndrome-and-pseudoexfoliation-glaucoma
#12
REVIEW
C Schweitzer
Pseudoexfoliation syndrome is an age-related systemic disease that mainly affects the anterior structures of the eye. Despite a worldwide distribution, reported incidence and prevalence of this syndrome vary widely between ethnicities and geographical areas. The exfoliative material is composed mainly of abnormal cross-linked fibrils that accumulate progressively in some organs such as the heart, blood vessels, lungs or meninges, and particularly in the anterior structures of the eye. The exact pathophysiological process still remains unclear but the association of genetic and environmental factors are thought to play a role in the development and progressive extracellular accumulation of exfoliative material...
January 9, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29328985/standing-on-a-sliding-board-affects-generation-of-anticipatory-and-compensatory-postural-adjustments
#13
Bing Chen, Yun-Ju Lee, Alexander S Aruin
Postural control is compromised in the presence of body instability. We studied anticipatory and compensatory postural adjustments people use to maintain balance while standing on an unstable surface and performing voluntary arm movements. Nine healthy participants stood on a sliding board (that was either locked and as such motionless or unlocked and as such free to move in the anterior-posterior direction) and performed fast bilateral arms flexion. Arm acceleration, bilateral electromyographic activity (EMG) of the trunk and lower extremity muscles and center of pressure (COP) displacements were recorded and analyzed within the intervals typical for the anticipatory (APAs) and compensatory (CPAs) postural adjustments...
December 28, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29320937/radiographic-measurements-associated-with-the-natural-progression-of-the-hallux-valgus-during-at-least-2-years-of-follow-up
#14
Seung Yeol Lee, Chin Youb Chung, Moon Seok Park, Ki Hyuk Sung, Sonya Ahmed, Seungbum Koo, Dong-Wan Kang, Kyoung Min Lee
BACKGROUND: This study aimed to investigate the radiographic measurements associated with the progression of hallux valgus during at least 2 years of follow-up. METHODS: Seventy adult patients with hallux valgus who were followed for at least 2 years and underwent weightbearing foot radiography were included. Radiographic measurements included the hallux valgus angle (HVA), hallux interphalangeal angle, intermetatarsal angle (IMA), metatarsus adductus angle, distal metatarsal articular angle (DMAA), tibial sesamoid position, anteroposterior (AP) talo-first metatarsal angle, and lateral talo-first metatarsal angle...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29319735/tibial-tunnel-enlargement-and-joint-instability-after-anterior-cruciate-ligament-reconstruction-a-prospective-comparison-between-autograft-and-allograft
#15
Qiang Zhang, Guangliang Hao, Mingyong Gu, Xuecheng Cao
PURPOSE: To investigate tibial tunnel widening and knee instability after ACL reconstruction with hamstring autograft or irradiated soft tissue allograft. METHODS: Eight-two patients were divided into two groups: autograft group and allograft group. Radiographic and clinical evaluations were performed. RESULTS: Seventy patients were followed up with median of 36.3 months (range 36-38 months). Tibial tunnel widening was at or greater than 30% for nine patients in the autograft group and 15 patients in the allograft group (P = 0...
December 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29313414/a-survey-of-phonological-mid-vowel-intuitions-in-central-catalan
#16
Margaret E L Renwick, Marianna Nadeu
Catalan, like other Romance languages, has two pairs of phonemic mid vowels (/be/ "well" vs. /bɛ/ "lamb"; /os/ "bear" vs. /ɔs/ "bone"). However, these contrasts do not function like others in the language: they are partially phonologically conditioned, and evidence shows that words may be pronounced with different mid vowels by speakers of the same variety or even by the same speaker. Spanish may influence this instability, as first-language Spanish Catalan-Spanish bilinguals struggle to perceive and produce the contrast...
January 1, 2018: Language and Speech
https://www.readbyqxmd.com/read/29309452/a-systematic-review-of-21-tibial-tubercle-osteotomy-studies-and-more-than-1000-knees-indications-clinical-outcomes-complications-and-reoperations
#17
Bryan M Saltzman, Allison Rao, Brandon J Erickson, Gregory L Cvetanovich, David Levy, Bernard R Bach, Brian J Cole
Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched the literature for tibial tubercle osteotomy (TTO) studies and systematically reviewed them for indications, clinical outcomes, complications, and reoperations. Therapeutic clinical studies that reported TTO indications, operative findings, and outcomes were included. Quality of each study was assessed with the modified Coleman methodology score (MCMS). Twenty-one studies (976 patients, 1055 knees) were included in the analysis...
November 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/29308633/blood-tissue-analysis-of-tp53-polymorphisms-and-survival-of-patients-with-glioma
#18
Pier P Panciani, Maria T Giordana, Salvatore Gallone, Andrea Muratori, Rosaria Rotunno, Karol Migliorati, Giannantonio Spena, Alessandro Ducati, Marco Fontanella
BACKGROUND: The role of single nucleotide polymorphisms (SNPs) in TP53 in the pathogenesis of glioma is debated. The aim of our study was to investigate the role of several TP53 SNPs in the risk of glioma and their possible role as prognostic biomarkers of overall and progression-free survival. METHODS: We examined 12 SNPs in TP53 from peripheral blood and neoplastic tissue of patients with a diagnosis of glioma who underwent surgery from 2012 to 2015. Direct genomic sequencing of TP53 was performed to detect the presence of polymorphisms...
January 4, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29308088/distinct-subtypes-of-genomic-pten-deletion-size-influence-the-landscape-of-aneuploidy-and-outcome-in-prostate-cancer
#19
Thiago Vidotto, Daniel Guimarães Tiezzi, Jeremy A Squire
Background: Inactivation of the PTEN tumor suppressor gene by deletion occurs in 20-30% of prostate cancer tumors and loss strongly correlates with a worse outcome. PTEN loss of function not only leads to activation of the PI3K/AKT pathway, but is also thought to affect genome stability and increase levels of tumor aneuploidy. We performed an in silico integrative genomic and transcriptomic analysis of 491 TCGA prostate cancer tumors. These data were used to map the genomic sizes of PTEN gene deletions and to characterize levels of instability and patterns of aneuploidy acquisition...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29307482/-relationship-between-perineal-characteristics-and-symptoms-and-pelvic-girdle-pain-a-literature-review
#20
M Rejano-Campo, A Desvergée, A C Pizzoferrato
INTRODUCTION: Pelvic girdle pain (PGP) is characterized by the presence of pain in the posterior pelvic area, distally and laterally to the fifth lumbar vertebra, and/or at the pubic symphysis. PGP is a very common pain condition in women, especially during pregnancy and postpartum. After delivery, pain prevalence decreases to 7 % in the first three months. The current literature describes an association between pelvic girdle pain and different perineal characteristics and symptoms...
January 4, 2018: Progrès en Urologie
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