Qianwen Li, Chen Jia, Wenjing Pan, Hongmei Liu, Congli Tang, Daniel Weber, Kaili Chen, Hai Long, Miranda L Byrne-Steele, Jian Han, Nongyue He, Rong Xiao, Ming Zhao, Nan Che, Qing Guo, Guangji Gui, Shanshan Li, Henan Si, Shuping Guo, Hongye Liu, Gang Wang, Guannan Zhu, Bin Yang, Yu Wang, Yan Ding, Xianxu Yang, Yoshimura Akihiko, Liwei Lu, Christopher Chang, Vera Chan, Chak-Sing Lau, Hai Qi, Wanli Liu, Song Li, Haijing Wu, Qianjin Lu
Lupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and immunopathogenesis. Is discoid lupus truly a form of LE or is it a completely separate entity? This question has not been fully elucidated...
April 20, 2024: Journal of Autoimmunity