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Gastric cancer with liver metastasis

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https://www.readbyqxmd.com/read/28186089/adenovirus-mediated-tipe2-overexpression-inhibits-gastric-cancer-metastasis-via-reversal-of-epithelial-mesenchymal-transition
#1
H Yin, X Huang, M Tao, Q Hu, J Qiu, W Chen, J Wu, Y Xie
Tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TNFAIP8L2; also termed TIPE2) has been shown to be involved in both the immune-negative modulation and cancer. We previously found that TIPE2 is lost in human gastric cancer, and TIPE2 restoration suppresses gastric cancer growth by induction of apoptosis and impairment of protein kinase B (PKB/AKT) and extracellular signal-regulated kinase-1/2 (ERK1/2) signaling. However, its correlation with epithelial-mesenchymal transition (EMT) in gastric cancer is largely elusive...
February 10, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28185236/regulation-of-osmolality-for-cancer-treatment
#2
REVIEW
Atsushi Shiozaki, Daisuke Ichikawa, Toshiyuki Kosuga, Yoshinori Marunaka, Eigo Otsuji
Disseminated metastasis is associated with a poor prognosis, and its management in the peritoneal or pleural cavity is crucial in the treatment of cancer. Recent studies show that ion and water transporters play important roles in fundamental cellular functions, including the regulation of cell volume that would be involved in the cancer process. Here, we review the evidence for hypotonic treatments of cancer and evaluate the potential of the cellular physiological approach in clinical management. The regulation of extracellular osmolality is a promising method, with several studies demonstrating the cytocidal effects of hypotonic solution on cancer cells...
February 10, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28133275/-a-case-of-multiple-liver-metastasis-from-gastric-cancer-successfully-treated-with-cpt-11-as-third-line-chemotherapy
#3
Satoru Kikuchi, Masahiko Nishizaki, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara
A 63-year-old man underwent proximal gastrectomy for early gastric cancer(pT1bN0M0, pStage I A). Twenty months after surgery, abdominal CT scans revealed multiple liver metastases. S-1 plus CDDP therapy was administered as first-line chemotherapy. After treatment, CT scans revealed tumor progression and nab-PTX was administrated. This treatment was ineffective; therefore, CPT-11 was administrated as third-line chemotherapy. Treatment with CPT-11 resulted in marked tumor reduction and improved the QOL of the patient; partial response was maintained for 8 months...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133184/-a-case-of-giant-liver-metastasis-from-gastric-cancer-after-surgery-for-which-transcatheter-arterial-embolization-and-chemotherapy-made-hepatic-resection-possible
#4
Fumiaki Ochi, Yusuke Takashima, Jun Shibamoto, Kento Kurashima, Ayana Sakuramachi, Tatsuya Matsumoto, Daisuke Iitaka, Susumu Nakashima, Junshin Fujiyama, Toshikazu Kato, Genichi Kato, Masamichi Banba, Mamoru Masuyama
The prognosis of liver metastasis from gastric cancer, which often exhibits incurable factors, is dismal, and no effective therapy exists. We report a case of giant liver metastasis from gastric cancer after surgery, for which transcatheter arterial embolism and chemotherapy(G-SOX)made it possible to perform hepatic resection. The patient was a 78-year-old woman who underwent distal gastrectomy combined with D2 lymphadenectomy at our department in August 2014. She complained of abdominal distension, and a liver metastasis measuring more than 16 cm in diameter was found on computed tomography in April 2015...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133128/-a-case-of-surgical-resection-for-liver-metastasis-of-gastric-cancer-treated-with-neoadjuvant-chemotherapy
#5
Soichiro Mori, Masahiro Tanemura, Kentaro Kishi, Mitsuyoshi Tei, Toru Masuzawa, Yozo Suzuki, Masahisa Otsuka, Kenta Furukawa, Yoshihiro Sakano, Kazunori Mori, Hiroki Akamatsu
The patient was a 73-year-old man. Upper gastrointestinal endoscopy revealed a type 3 tumor in the antrum of the stomach. Preoperative CT imaging showed multiple liver metastases(S2, S3, S4, S6, S7). We administered 2 courses of chemotherapy( XP therapy)for the unresectable gastric cancer; the impact of the neoadjuvant therapy was PR. We performed distal gastrectomy and D2 dissection. After gastric resection, we administered an additional 3 courses of XP therapy. Unfortunately, new lesions of liver metastases were recurrent at S5 and S8...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133037/-a-case-of-port-site-recurrence-after-laparoscopic-distal-gastrectomy-for-advanced-gastric-cancer
#6
Shotaro Fujita, Shinji Ohki, Koji Kase, Naoto Yamauchi, Shun Chida, Suguru Hayase, Wataru Sakamoto, Tomoyuki Monma, Masashi Takawa, Toru Ohtake, Koji Kono, Seiichi Takenoshita
It has been suggested that port site recurrence is a potential complication after laparoscopic distal gastrectomy for gastric cancer, especially considering the increased number of laparoscopic surgeries being performed. We encountered a case of an 84-year-old man who was diagnosed with 2 port site recurrences at the navel and right hypochondrium after laparoscopic distal gastrectomy(D2). Pathological diagnosis for the original tumor was tub2, pT4a, pN1(1/38), M0, pStage III A, and HER2(0). As first-line chemotherapy with S-1 plus CDDP for the port site recurrence failed, second-line chemotherapy with ramucirumab plus paclitaxel(RAM plus PTX)was administered...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28098914/role-of-mir-647-in-human-gastric-cancer-suppression
#7
Wenlong Cao, Weiyuan Wei, Zexu Zhan, Dongyi Xie, Yubo Xie, Qiang Xiao
MicroRNAs (miRNAs) regulate various oncogenes concomitantly, resulting in tumor suppression. They regulate proliferation and migration pathways in tumor development, suggesting a potential therapeutic role. In the present study, we found that miR-647 was markedly downregulated in gastric cancer (GC), and was significantly correlated with reduced tumor size and metastasis. In addition, miR-647 was also reduced in GC cell lines. Furthermore, overexpression of miR-647 in the GC cell lines inhibited cell proliferation, promoted cell cycle arrest at the G0/G1 phase and induced cell apoptosis...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28008721/therapy-of-primary-and-metastatic-liver-cancer-by-human-ips-cell-derived-myeloid-cells-producing-interferon-%C3%AE
#8
Masataka Sakisaka, Miwa Haruta, Yoshihiro Komohara, Satoshi Umemoto, Keiko Matsumura, Tokunori Ikeda, Motohiro Takeya, Yukihiro Inomata, Yasuharu Nishimura, Satoru Senju
BACKGROUND: iPS-ML are myeloid lineage cells with a proliferative capacity derived from induced pluripotent stem (iPS) cells. This study aimed to examine therapeutic effect of iPS-ML producing interferon-β (iPS-ML/IFN-β) towards primary and metastatic liver cancer and investigate the mechanism of that effect. METHODS: We established a xenograft model of liver metastasis by injecting the spleen of SCID mice with MKN-45 human gastric cancer cells and also a primary liver cancer model by injecting SK-HEP-1 human hepatocellular carcinoma cells into the liver...
December 23, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/28000200/-efficacy-and-safety-of-surgery-combined-with-hyperthermic-intraperitoneal-chemotherapy-in-the-treatment-of-advanced-gastric-cancer-a-meta-analysis
#9
Zhentian Ni, Chen Li, Chao Yan, Wentao Liu, Xuexin Yao, Mingmin Chen, Min Yan, Zhenggang Zhu
OBJECTIVE: To systematically evaluate the efficacy and safety of surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of advanced gastric cancer (AGC). METHODS: Clinical control trials about the efficacy and safety of surgery combined with HIPEC in the treatment of advanced gastric cancer published before June 2014 were searched in Embase, PubMed, Cochrane Library, Wanfang database and CNKI database. Quality of enrolled articles was evaluated with the guidelines from Cochrane collaborative network...
December 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27995033/extremely-high-expression-of-serum-alpha-fetoprotein-level-of-gastric-adenocarcinoma-a-rare-case-with-an-unexpected-well-prognosis
#10
Weihua Gong, Dawei Shou, Ping Gong
INTRODUCTION: Alpha-fetoprotein (AFP)-producing gastric cancer is a relatively rare form of stomach malignancy. Patients with higher serum AFP level (>300 ng/mL) will have a poorer prognosis. CASE DESCRIPTION: In this study, we present a case of 77-year-old woman with an extremely high expression of serum AFP level (>10,000 ng/mL) of gastric cancer. Histological examination revealed gastric adenocarcinoma (Bormann III gastric tumor) invading into the serosal layer and vessel...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27986169/hepatic-steatosis-etiology-patterns-and-quantification
#11
Ilkay S Idilman, Ilknur Ozdeniz, Musturay Karcaaltincaba
Hepatic steatosis can occur because of nonalcoholic fatty liver disease (NAFLD), alcoholism, chemotherapy, and metabolic, toxic, and infectious causes. Pediatric hepatic steatosis is also becoming more frequent and can have distinctive features. The most common pattern is diffuse form; however, it can present in heterogenous, focal, multinodular, perilesional, perivascular, subcapsular, and lobar forms. Focal steatosis and fat sparing can occur because of the presence of veins of Sappey, pancreaticoduodenal vein, and aberrant right and left gastric veins, which drain into the liver as third inflow...
December 2016: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/27965933/colorectal-choriocarcinoma-in-a-patient-with-probable-lynch-syndrome
#12
Viktor H Koelzer, Karl Steuer, Ulrike Camenisch Gross, Dieter Zimmermann, Aino Paasinen-Sohns, Kirsten D Mertz, Gieri Cathomas
BACKGROUND: Personalized therapy of colorectal cancer is influenced by morphological, molecular, and host-related factors. Here, we report the comprehensive clinicopathological and molecular analysis of an extra-gestational colorectal choriocarcinoma in a patient with probable Lynch syndrome. CASE PRESENTATION: A 61-year-old female with history of gastric cancer at age 36 presented with a transmurally invasive tumor of the right hemicolon and liver metastasis. A right hemicolectomy was performed...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27913881/phase-ii-trial-of-s-1-plus-leucovorin-in-patients-with-advanced-gastric-cancer-and-clinical-prediction-by-s-1-pharmacogenetic-pathway
#13
Ming-Ming He, Dong-Sheng Zhang, Feng Wang, Zi-Xian Wang, Shu-Qiang Yuan, Zhi-Qiang Wang, Hui-Yan Luo, Chao Ren, Miao-Zhen Qiu, Ying Jin, De-Shen Wang, Dong-Liang Chen, Zhao-Lei Zeng, Yu-Hong Li, Yang-Yang He, Yuan-Tao Hao, Pi Guo, Feng-Hua Wang, Yi-Xin Zeng, Rui-Hua Xu
BACKGROUND: The first one-arm phase II trial aimed to evaluate and predict efficacy and safety of S-1 plus oral leucovorin (S-1/LV) as first-line chemotherapy for patients with advanced gastric cancer (AGC), using S-1 pharmacogenetic pathway approach. PATIENTS AND METHODS: A total of 39 patients orally took S-1 at conventional dose and LV simultaneously at a dose of 25 mg twice daily for a week, within a 2-week cycle. The primary endpoint was overall response rate (ORR), while the secondary endpoints were progression-free survival (PFS), time to failure (TTF), overall survival (OS), disease control rate (DCR), and adverse events (AEs)...
January 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27843732/resection-of-large-metachronous-liver-metastasis-with-gastric-origin-case-report-and-review-of-the-literature
#14
REVIEW
Ionut Negoi, Alexandru Runcanu, Sorin Paun, Ruxandra Irina Negoi, Mircea Beuran
INTRODUCTION: Increasing evidence suggests that surgical resection may be offered to a subgroup of patients with liver metastasis of gastric adenocarcinoma. The aim of this case report is to illustrate the surgical resection of a single liver metachronous recurrence twelve months after a radical total gastrectomy for cancer. CASE REPORT: A 63-year-old male patient with an Eastern Cooperative Oncology Group performance status of 1 was referred to our hospital for a single, large liver metastasis, twelve months after a radical total gastrectomy and DII lymphadenectomy for upper third gastric adenocarcinoma...
October 3, 2016: Curēus
https://www.readbyqxmd.com/read/27829227/targeted-therapy-of-multiple-liver-metastases-after-resected-solitary-gastric-metastasis-and-primary-pulmonary-adenocarcinoma
#15
Ling-Yu Ding, Ke-Jun Liu, Zhe-Long Jiang, Hai-Ying Wu, Shi-Xi Wu
Gastric metastases from lung adenocarcinoma are rare and usually asymptomatic. A 61-year-old woman was referred to our department because of a right lower pulmonary mass found on a chest X-ray film in August 2012. Right lower lobectomy was performed for pulmonary adenocarcinoma. Four months later, she developed epigastric discomfort. A fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) scan showed a malignancy at the cardias of the stomach. A biopsy diagnosed poorly differentiated carcinoma and a gastric carcinoma was suspected...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27826197/elevated-habp1-protein-expression-correlates-with-progression-and-poor-survival-in-patients-with-gastric-cancer
#16
Hongyu Gao, Qiang Yao, Xiuwen Lan, Sen Li, Junlong Wu, Guangchun Zeng, Yingwei Xue
BACKGROUND: Hyaluronic acid-binding protein 1 (HABP1/gC1qR/p32) has been recently implicated in oncogenesis and cancer progression in various malignancies; however, its clinical role in gastric cancer (GC) is still unclear. PATIENTS AND METHODS: First, HABP1 expression was determined by Western blot analysis and immunohistochemistry. Then, we evaluated the expression of HABP1 and its clinical significance in tumor tissues from 181 patients with GC. RESULTS: Expression of HABP1 protein in GC tissues was noticeably higher than that in adjacent nonneoplastic tissues (P=0...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27781386/hulc-an-oncogenic-long-non-coding-rna-in-human-cancer
#17
REVIEW
Xin Yu, Heyi Zheng, Matthew T V Chan, William Ka Kei Wu
Highly up-regulated in liver cancer (HULC) was originally identified as the most overexpressed long non-coding RNA in hepatocellular carcinoma. Since its discovery, the aberrant up-regulation of HULC has been demonstrated in other cancer types, including gastric cancer, pancreatic cancer, osteosarcoma and hepatic metastasis of colorectal cancer. Recent discoveries have also shed new light on the upstream molecular mechanisms underlying HULC deregulation. As an oncogene, HULC promotes tumorigenesis by regulating multiple pathways, such as down-regulation of EEF1E1, promotion of abnormal lipid metabolism, and up-regulation of sphingosine kinase 1...
February 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27770343/fam46c-serves-as-a-predictor-of-hepatic-recurrence-in-patients-with-resectable-gastric-cancer
#18
Haruyoshi Tanaka, Mitsuro Kanda, Dai Shimizu, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Naoki Iwata, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Michitaka Fujiwara, Yukiko Niwa, Yasuhiro Kodera
BACKGROUND: Gastric cancer (GC) relapse can occur even if curative resection is achieved. Biomarkers predicting recurrence are needed to provide appropriate postoperative surveillance and perioperative therapeutic strategy. METHODS: A global expression profiling was performed using tissues from GC patients with synchronous liver-confined metastasis. Family with sequence similarity 46, member C (FAM46C), was identified as a candidate biomarker. mRNA expression analysis, direct nucleotide sequencing, bisulfite sequencing and copy number assays for FAM46C were performed with eleven GC cell lines...
October 21, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27760941/-a-case-of-long-term-survival-after-combination-therapy-for-gastric-cancer-with-synchronous-multiple-liver-metastasis
#19
Satoshi Kiyota, Yumi Matsuda, Syoji Hanada, Masahiko Kinoshita, Satoshi Nishizawa, Genichi Kanazawa, Hiromu Tanaka
A 63-year-old man was admitted to our hospital owing to weight loss and vertigo. Endoscopic examination revealed advanced gastric cancer type 2. Abdominal CT showed a 62mm liver tumor in segment 4 and a 26mm tumor in segment 8. Distal gastrectomy and D2 lymph node dissection were performed. After surgery, he was administered chemotherapy with S- 1. After 2 courses of treatment, the tumors' in segments 4 and 8 were reduced to 52mm and 16mm, respectively. No other metastases were detected. Left lobectomy and partial resection of segment 8 were performed...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27760940/-a-case-of-her2-positive-advanced-gastric-cancer-with-multiple-liver-metastases-effectively-treated-with-trastuzumab-capecitabine-and-cisplatin-combination-therapy
#20
Yoshio Kuga, Shosuke Kitamura, Hideharu Okanobu, Hideto Sakimoto, Toshihiro Nishida
We reported a case of human epidermal growth factor receptor 2(HER2)-positive advanced gastric cancer with multiple liver metastases that responded well to a combination of trastuzumab, capecitabine, and cisplatin(T-XP therapy)as first-line chemotherapy. A 73-year-old man was admitted to our hospital in December 2012 for liver dysfunction. Based on computed tomography(CT)and gastroendoscopy findings, he was diagnosed with advanced gastric cancer with multiple liver metastases. Because HER2 protein overexpression was observed in the primary tumor, he was treated with T-XP therapy...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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