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Gastric cancer with liver metastasis

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https://www.readbyqxmd.com/read/29650855/-a-case-of-double-cancer-of-intrahepatic-cholangiocarcinoma-and-gastric-carcinoma-with-difficult-diagnosis-of-the-primary-tumor-with-peritoneal-metastasis
#1
Hiroyuki Kanomata, Yasuji Seyama, Hiroki Kudo, Toru Tanizawa, Masahiro Warabi, Masamichi Takahashi, Yujiro Matsuoka, Ikuo Wada, Masayuki Takegami, Yukio Miyamoto, Nobutaka Umekita
Double cancer of intrahepatic cholangiocarcinoma and gastric cancer is rare. A 62-year-old man underwent gastrectomy for gastric cancer. The pathological findings were tub1>tub2, m, ly0, v0, n0, Stage I A. Two years and a month later, a liver tumor(diameter of 3 cm)and a pelvic mass(diameter of 2.5 cm)were observed. Metastasis from gastric cancer was suspected and chemotherapy(SOX)was administered. However, after 5 courses, CT revealed worseningof the liver tumor (diameter of 12 cm)and pelvic mass(diameter of 3 cm)...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650826/-a-case-in-which-s-1-plus-cddp-and-s-1-therapy-responded-to-liver-metastasis-recurrence-after-gastric-cancer-operation
#2
Takeharu Enomoto, Shinya Mikami, Mina Kitajima, Masaki Hiwatari, Tatsunori Ono, Natsuko Sasaki, Osamu Saji, Tsunehisa Matsushita, Shinjiro Kobayashi, Satoshi Koizumi, Yasushi Ariizumi, Takako Nakajima, Takehito Otsubo
A 55-year-old man underwent distal gastrectomy and D2 lymph node dissection for type 2 gastric cancer of the antrum. One year later, CEA elevation was discovered, and contrast-enhanced abdominal computed tomography(CT)revealed a 40 mm mass in the liver(S8), which was judged to be a metastatic recurrence of the gastric cancer.S -1 plus CDDP was administered in 5 courses, followed by regular treatment with S-1 alone.Two years after the recurrence was diagnosed, the patient's CEA level was found to be normal, and CT revealed almost total scarring...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29604141/pgd2-ptgdr2-signaling-restricts-the-self-renewal-and-tumorigenesis-of-gastric-cancer
#3
Bin Zhang, Qingli Bie, Peipei Wu, Jie Zhang, Benshuai You, Hui Shi, Hui Qian, Wenrong Xu
The antitumor effect of prostaglandin D2 (PGD2) on gastric cancer (GC) has been known for decades. However, the mechanism of PGD2's control of GC growth is unclear. Cancer stem cells (CSCs) are implicated in tumor neovascularization, invasiveness, and therapeutic resistance. Herein, we discovered that signaling between PGD2 and its receptor (PTGDR2) has the ability to restrict the self-renewal of GC cells in vitro and suppress tumor growth and metastasis in vivo. To obtain these findings, we first determined that PGD2 synthase (L-PTGDS) and PTGDR2 expression were lower in GC tissues than adjacent tissues and was associated with the patients' prognosis...
March 31, 2018: Stem Cells
https://www.readbyqxmd.com/read/29581580/reduced-expression-of-the-h19-long-non-coding-rna-inhibits-pancreatic-cancer-metastasis
#4
Hisashi Yoshimura, Yoko Matsuda, Masami Yamamoto, Masaki Michishita, Kimimasa Takahashi, Norihiko Sasaki, Naoshi Ishikawa, Junko Aida, Kaiyo Takubo, Tomio Arai, Toshiyuki Ishiwata
H19 is an oncofetal RNA expressed in the developing embryo as well as in bladder, breast, gastric, pancreatic, hepatocellular, and prostate cancers. Recent studies have shown that H19 enhances cancer invasion and metastasis; however, its roles in cancer remain controversial. In the current study, H19 exhibited the second largest increase (82.4-fold) and represented the only non-protein coding gene among 11 genes identified that were elevated over 10-fold in lung-metastasis-derived pancreatic cancer cells compared with their parental cells using a mouse metastatic model...
March 26, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29550974/the-pleiotropic-roles-of-adam9-in-the-biology-of-solid-tumors
#5
REVIEW
Victor O Oria, Paul Lopatta, Oliver Schilling
A disintegrin and a metalloprotease (ADAM) 9 is a metzincin cell-surface protease involved in several biological processes such as myogenesis, fertilization, cell migration, inflammatory response, proliferation, and cell-cell interactions. ADAM9 has been found over-expressed in several solid tumors entities such as glioma, melanoma, prostate cancer, pancreatic ductal adenocarcinoma, gastric, breast, lung, and liver cancers. Immunohistochemical analyses highlight ADAM9 expression by actual cancer cells and associate its abundant presence with clinicopathological features such as shortened overall survival, poor tumor grade, de-differentiation, therapy resistance, and metastasis formation...
March 17, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29547756/silencing-of-discoidin-domain-receptor-1-ddr1-concurrently-inhibits-multiple-steps-of-metastasis-cascade-in-gastric-cancer
#6
Ryo Yuge, Yasuhiko Kitadai, Hidehiko Takigawa, Toshikatsu Naito, Naohide Oue, Wataru Yasui, Shinji Tanaka, Kazuaki Chayama
Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated the expression and role of DDR1 in human gastric cancer metastasis. Proliferation, migration, invasion, and tube formation assays were conducted in DDR1-expressing MKN74 gastric cancer cells and corresponding DDR1-silenced cells. The effects of DDR1 on tumor growth and metastasis were examined in orthotopically implanted and experimental liver metastasis models in nude mice...
March 13, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29500465/the-role-of-osteopontin-in-the-progression-of-solid-organ-tumour
#7
REVIEW
Hailin Zhao, Qian Chen, Azeem Alam, Jiang Cui, Ka Chun Suen, Aurelie Pac Soo, Shiori Eguchi, Jianteng Gu, Daqing Ma
Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment to mineralised bone matrix, as well as being a bone matrix protein, OPN is also a versatile protein that acts on various receptors which are associated with different signalling pathways implicated in cancer. OPN mediates various biological events involving the immune system and the vascular system; the protein plays a role in processes such as immune response, cell adhesion and migration, and tumorigenesis. This review discusses the potential role of OPN in tumour cell proliferation, angiogenesis and metastasis, as well as the molecular mechanisms involved in these processes in different cancers, including brain, lung, kidney, liver, bladder, breast, oesophageal, gastric, colon, pancreatic, prostate and ovarian cancers...
March 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29492920/-d2-radical-resection-of-omental-bursa-and-no-12p-and-no-8p-for-gastric-carcinoma-a-retrospectively-analysis-from-a-single-center-in-china
#8
Luchuan Chen, Shenghong Wei, Zaisheng Ye, Jun Xiao, Yi Zeng, Yi Wang, Zhenmeng Lin, Zhitao Lin, Xiaoling Chen
OBJECTIVE: To evaluate the safty and feasibility of the D2 radical resection of omental bursa and No.12p and No.8p for gastric carcinoma (GC). METHODS: Clinical data of 1801 GC patients undergoing D2 radical resection of omental bursa and No.12p and No.8p at Fujian Medical University Cancer Hospital from January 2000 to January 2010 were analyzed retrospectively. Inclusion case criteria: (1)age of 18 to 90 years;(2)pathologically diagnosed as GC and receiving D2 radical resection of omental bursa and No...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29491090/a-case-of-15-year-recurrence-free-survival-after-microwave-coagulation-therapy-for-liver-metastasis-from-gastric-cancer
#9
Koichi Kinoshita, Toru Beppu, Tatsunori Miyata, Kunitaka Kuramoto, Yasushi Yoshida, Naoki Umesaki, Yuki Kitano, Shigeki Nakagawa, Hirohisa Okabe, Hidetoshi Nitta, Katsunori Imai, Hiromitsu Hayashi, Yo-Ichi Yamashita, Hiroyuki Komori, Kei Horino, Atsunobu Misumi, Hideo Baba
A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of small liver metastases from gastric cancer in segment 8, the patient underwent open microwave coagulation therapy (MCT) for the tumor (diameter: 30 mm) in segment 4. MCT was performed by using 1.5-cm and 3-cm monopolar needle electrodes with 22 times of puncture under the condition of 100 W × 60 sec...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29483454/-three-cases-of-long-term-surviving-stage-iv-gastric-cancer-after-conversion-surgery
#10
Suguru Nukada, Tsutomu Sato, Toru Aoyama, Mariko Kamiya, Shinya Amano, Shuzo Tamura, Takanobu Yamada, Naoto Yamamoto, Hiroshi Harada, Takashi Oshima, Haruhiko Cho, Takaki Yoshikawa, Shoji Yamanaka, Yasushi Rino, Munetaka Masuda
The standard therapy for Stage IV gastric cancer is chemotherapy. It is not certain, but conversion surgery is expected to be effective. We report the cases of 3 patients who achieved long-term survival after conversion surgery. Case 1 was of a 59- year-old woman. The tumor was classified as L-Less Post, Type 2, tub1, cT3N2M1(#16a2lat), Stage IV. Then, we initiated S-1 plus cisplatin and the LN achieved PRafter 4 courses. We performed distal gastrectomy with D2 lymph node dissection in February 2011. It was classified as ypT2N2 and the primary lesion was histologically classified as Grade 1a...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29468059/oxaliplatin-induced-hepatic-sinusoidal-obstruction-syndrome-in-a-patient-with-gastric-cancer-a-case-report
#11
Fang Liu, Xin Cao, Jin Ye, Xiaoli Pan, Xuefeng Kan, Yuhu Song
Oxaliplatin is a platinum-based antineoplastic agent used in cancer chemotherapy. Oxaliplatin-induced hepatic sinusoidal obstruction syndrome (HSOS) has been reported in the context of chemotherapy for liver metastasis of colorectal cancer. However, to the best of our knowledge, there is no report of oxaliplatin-associated HSOS in patients with gastric cancer. The present study reported a patient with gastric cancer who received proximal gastrectomy and oxaliplatin-containing chemotherapy. Contrast-enhanced computed tomography revealed that liver parenchyma appeared heterogeneous and demonstrated hypoattenuation in the portal phase...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29465550/clinical-significance-of-computed-tomography-detected-ascites-in-gastric-cancer-patients-with-peritoneal-metastases
#12
Su Hwan Kim, Young Ho Choi, Ji Won Kim, Sohee Oh, Seohui Lee, Byeong Gwan Kim, Kook Lae Lee
Patients with peritoneal metastases (PM) are generally considered incurable; therefore, the presence of PM is a critical factor in deciding between palliative surgery and curative resection as a therapeutic strategy. Previous studies have not determined the predictive value of ascites detected on computed tomography (CT) for the presence of PM. We aimed to analyze the factors that are associated with PM in patients with CT-detected ascites.A total of 2207 consecutive patients who were diagnosed with gastric cancer between 2004 and 2013 were identified...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464402/clinical-outcomes-of-minimally-invasive-treatment-for-early-gastric-cancer-in-patients-beyond-the-indications-of-endoscopic-submucosal-dissection
#13
Weon Jin Ko, Yoo Min Kim, In Kyung Yoo, Joo Young Cho
BACKGROUND: Endoscopic submucosal dissection (ESD) with laparoscopic sentinel lymph node dissection (ESN) and endoscopic full-thickness gastric resection with laparoscopic sentinel lymph node dissection (Hybrid-natural orifice transluminal endoscopic surgery, Hybrid-NOTES) are minimally invasive treatment options for early gastric cancer (EGC) beyond the indications of ESD. This study aimed to evaluate the short- and long-term clinical outcomes of ESN and Hybrid-NOTES. METHODS: We retrospectively analyzed patients who had undergone ESN or Hybrid-NOTES for EGC from January 2009 to March 2013...
February 20, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29398875/neuroendocrine-carcinoma-of-the-gastric-stump-a-case-report-and-literature-review
#14
Fu-Hai Ma, Li-Yan Xue, Ying-Tai Chen, Yi-Bin Xie, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian
We herein report a case of neuroendocrine carcinoma of the gastric stump found 47 years after Billroth II gastric resection for a benign gastric ulcer. A 74-year-old man was referred to another hospital with melena. Endoscopic examination revealed a localized ulcerative lesion at the gastrojejunal anastomosis. The diagnosis by endoscopic biopsy was neuroendocrine carcinoma. A total gastrectomy of the remnant stomach with D2 lymphadenectomy was performed at our hospital. The lesion invaded the subserosa, and metastasis was found in two of nine the lymph nodes retrieved...
January 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29394842/-stereotactic-body-radiotherapy-for-liver-metastasis-of-gastric-cancer
#15
So Katayanagi, Yousuke Makuuchi, Hiroaki Osakabe, Masatoshi Shigoka, Tetsuo Sumi, Akihiko Tsuchida, Shigeyuki Kawachi
Case 1: A 69-year-old man underwent distal gastrectomy in September 2007 for type 2 gastric cancer with liver metastasis (S5). After the operation, we administered chemotherapy. After that, we performed partial hepatectomy in July 2008. After hepatectomy, liver metastases appeared as 2 lesions in February 2009. Thus, we administered another type of chemotherapy. The effect of the chemotherapy was not favorable. Therefore, SBRT was performed for the liver metastases in December. After SBRT, he did not present with any recurrent tumors...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394810/-a-case-of-neuroendocrine-carcinoma-with-liver-metastasis-treated-with-multimodality-therapy-and-leading-to-complete-response
#16
Hiroaki Osakabe, So Katayanagi, Yosuke Makuuchi, Masatoshi Shigoka, Tetsuo Sumi, Kenji Katsumata, Akihiko Tsuchida, Shigeyuki Kawachi
A 79-year-old man with cStage II A(T2N1H0P0CYXM0)advanced gastric cancer in angle. Distal gastrectomy was performed and liver metastasis was recognized during the operation. The pathological diagnosis was shown as neuroendocrine carcinoma(NEC). Chemotherapy(S-1/cisplatin[CDDP]: 1 course, etoposide/CDDP: 5 courses)was administered. After chemotherapy, liver metastasis disappeared for 9months.
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394772/-a-case-of-alpha-fetoprotein-producing-gastric-cancer-with-synchronous-liver-metastasis-achieving-recurrence-free-survival-for-five-years-by-gastrectomy-hepatectomy-and-adjuvant-chemotherapy
#17
Yusuke Akamaru, Noriko Wada, Takafumi Hirao, Hirofumi Ota, Osakuni Morimoto, Kazuya Sakata, Daisuke Takiuchi, Kunitaka Shibata, Hirotsugu Ohashi
a-fetoprotein(AFP)-producing gastric cancer is relatively rare and tends to show a poor prognosis because of hepatic and lymph node metastasis. We experienced a case of AFP-producing gastric cancer with synchronous liver metastasis wherein the patient survived for 5 years without recurrence after undergoing surgery and adjuvant chemotherapy. A 39-year-old woman was admitted to our hospital complaining of tarry stool. Upper gastrointestinal endoscopy revealed a 40mm type 2 tumor in the greater curvature of the lower gastric body, and abdominal CT indicated a 50mm liver metastasis at the S2 segment...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394735/-two-cases-of-her2-positive-gastric-cancer-with-multiple-liver-metastases-leading-to-conversion-therapy-with-chemotherapy
#18
Hidetaka Andrew Ono, Miyuki Kaneshiro, Masayuki Nakashima, Hiroyuki Baba, Tetsuo Abe, Jiro Kumagai, Mitsutaka Sugita
Case 1: A 69-year-old man underwent chemotherapy with capecitabine plus cisplatin plus trastuzumab to treat advanced gastric cancer that was diagnosed as cStage IV adenocarcinoma(T3N2M1[P0, CYX, H1]). After 12 courses, liver metastases were absent on computed tomography images. The patient underwent total gastrectomy with D2 lymphadenectomy. It has been 22 months since the patient had gastrectomy without recurrence of the cancer. Case 2: A 70-year-old man underwent chemotherapy with capecitabine plus cisplatin plus trastuzumab for treatment of advanced gastric cancer that was diagnosed as cStage IV adenocarcinoma(T4aN1M1[P0, CY0, H1])...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394686/-a-case-of-liver-metastasis-from-esophageal-cancer-successfully-treated-by-surgical-resection-after-chemotherapy-with-weekly-paclitaxel
#19
Akinori Nozawa, Naoshi Kubo, Sadatoshi Shimizu, Akihiro Murata, Akishige Kanazawa, Shintaro Kodai, Yorihisa Urata, Kotaro Miura, Jun Tauchi, Katsunori Sakurai, Akiko Tachimori, Yutaka Tamamori, Toru Inoue, Yoshito Yamashita, Yukio Nishiguchi
A 58-year-old man complaining of dysphagia was admitted to our hospital and diagnosed with esophageal cancer.He underwent thoracoscopic subtotal esophagectomy with 3-field lymph node dissection and reconstruction with a gastric tube created by hand-assisted laparoscopy.The pathological diagnosis was classified as AeLtG, pT3N2M0, pStage III .He was subsequently treated with systemic chemotherapy with 5-fluorouracil and cisplatin.After 2 courses, a single liver metastatic tumor appeared at segment 5.As chemotherapy against the recurrence, weekly-paclitaxel was administered...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394663/-a-case-of-advanced-gastric-cancer-with-liver-metastasis-treated-by-curative-surgery-after-chemotherapy-using-s-1-plus-oxaliplatin
#20
Tsutomu Namikawa, Yasuhio Kawanishi, Yuki Fujieda, Kazune Fujisawa, Eri Munekage, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Michiya Kobayashi, Kazuhiro Hanazaki
A 76-year-old man was referred to our hospital with gastric cancer.Esophagogastroduodenoscopy (EGD)revealed an irregular, nodulated lesion with ulcers in the lower part of the stomach, for which biopsy specimens indicated poorly differentiated adenocarcinoma.Abdominal computed tomography(CT)showed a well-defined mass lesion measuring 5.3 cm in the posterior segment of the liver.Under the clinical diagnosis of advanced gastric cancer with liver metastasis, the patient received chemotherapy using S-1 and oxaliplatin...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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