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Filaggrin

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https://www.readbyqxmd.com/read/29876372/fibroblast-and-keratinocyte-gene-expression-following-exposure-to-the-extracts-of-holy-basil-plant-ocimum-tenuiflorum-malabar-nut-plant-justicia-adhatoda-and-emblic-myrobalan-plant-phyllanthus-emblica
#1
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R G S Wijesekara
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of holy basil plant ( Ocimum tenuiflorum ), sri lankan local name "maduruthala", 0.1% and 0.01% extracts of malabar nut plant ( Justicia adhatoda ), sri lankan local name "adayhoda" and 0.003% and 0.001% extracts of emblic myrobalan plant ( Phyllanthus emblica ), sri lankan local name "nelli", harvested in Sri Lanka. For fibroblasts, the dataset includes expression profiles for genes encoding hyaluronan synthase 1 (HAS1), hyaluronan synthase 2 (HAS2), hyaluronidase-1 (HYAL1), hyaluronidase-2 (HYAL2), versican, aggrecan, CD44, collagen, type I, alpha 1 (COL1A1), collagen, type III, alpha 1 (COL3A1), collagen, type VII, alpha 1 (COL7A1), matrix metalloproteinase 1 (MMP1), acid ceramidase, basic fibroblast growth factor (bFGF), fibroblast growth factor-7 (FGF7), vascular endothelial growth factor (VEGF), interleukin-1 alpha (IL-1α), cyclooxygenase-2 (cox2), transforming growth factor beta (TGF-β), and aquaporin 3 (AQP3)...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29867965/increased-production-of-il-17a-producing-%C3%AE-%C3%AE-t-cells-in-the-thymus-of-filaggrin-deficient-mice
#2
Mia Hamilton Jee, Jeanne Duus Johansen, Terkild Brink Buus, Trine Hilkjær Petersen, Anne-Sofie Østergaard Gadsbøll, Anders Woetmann, Niels Ødum, Jacob Pontoppidan Thyssen, Andrea Jane White, Graham Anderson, Carsten Geisler, Charlotte Menné Bonefeld
Mutations in the filaggrin gene ( Flg ) are associated with increased systemic levels of Th17 cells and increased IL-17A production following antigen exposure in both humans and mice. In addition to Th17 cells, γδ T cells can produce IL-17A. The differentiation of γδ T cells to either IFNγ or IL-17A-producing (γδT17) cells is mainly determined in the thymus. Interestingly, it has been reported that filaggrin is expressed in the Hassall bodies in the human thymic medulla. However, whether filaggrin affects γδ T cell development is not known...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29866992/upregulation-of-flg-lor-and-ivl-expression-by-rhodiola-crenulata-root-extract-via-aryl-hydrocarbon-receptor-differential-involvement-of-ovol1
#3
Akiko Hashimoto-Hachiya, Gaku Tsuji, Mika Murai, Xianghong Yan, Masutaka Furue
Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion...
June 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29863755/ph-in-nature-humans-and-skin
#4
REVIEW
Ehrhardt Proksch
The pH plays an important physiological role in nature and humans. pH varies from 1 to 8 in human organs with tight regulation in blood and epithelia of barrier organs. The physiological pH of the stratum corneum is 4.1-5.8 and several mechanisms contribute to its formation: filaggrin degradation, fatty acid content, sodium-hydrogen exchanger (NHE1) activation and melanosome release. First, the acidic pH of the stratum corneum was considered to present an antimicrobial barrier preventing colonization (e.g. by Staphylococcus aureus and Malassezia)...
June 4, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29851147/effects-of-a-ceramide-containing-water-in-oil-ointment-on-skin-barrier-function-and-allergen-penetration-in-an-il-31-treated-3d-model-of-the-disrupted-skin-barrier
#5
Sebastian Huth, Laurenz Schmitt, Yvonne Marquardt, Ruth Heise, Bernhard Lüscher, Philipp M Amann, Jens M Baron
Atopic dermatitis (AD) is a chronically relapsing, pruritic inflammation of the skin with dryness and disturbed skin barrier function. Recently, we established that IL-31 treatment of human 3D skin models resulted in a disrupted skin barrier phenotype resembling AD. In this model we found that IL-31 interferes with the differentiation of keratinocytes and inhibits the expression of terminal differentiation markers. In the present study, we investigated the effects of a ceramide containing water-in-oil skin care ointment on the physical skin barrier structure and function in disrupted skin barrier models, generated either by using primary normal human epidermal keratinocytes (NHEK) or HaCaT cells...
May 31, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29851030/individuals-with-filaggrin-related-eczema-and-asthma-have-increased-long-term-medication-and-hospital-admission-costs
#6
P Soares, K Fidler, J Felton, R Tavendale, A Hövels, S A Bremner, C N A Palmer, S Mukhopadhyay
BACKGROUND: Eczema and asthma are chronic diseases with onset usually before the age of 5 years. More than 50% of individuals with eczema will develop asthma and/or other allergic diseases. Several loss-of-function mutations in filaggrin (FLG) have been identified in patients with eczema. However, the association of FLG with healthcare use is unknown. OBJECTIVES: To determine whether FLG mutations are associated with increased prescribing for eczema and asthma and whether increased prescribing is associated with increased healthcare costs...
May 31, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29802017/topical-lyophilized-targeted-lipid-nanoparticles-in-the-restoration-of-skin-barrier-function-following-burn-wound
#7
Jilong Li, Subhadip Ghatak, Mohamed S El Masry, Amitava Das, Yang Liu, Sashwati Roy, Robert J Lee, Chandan K Sen
Lyophilized keratinocyte-targeted nanocarriers (TLNκ ) loaded with locked nucleic acid (LNA) modified anti-miR were developed for topical application to full thickness burn injury. TLNκ were designed to selectively deliver LNA-anti-miR-107 to keratinocytes using the peptide sequence ASKAIQVFLLAG. TLNκ employed DOTAP/DODAP combination pH-responsive lipid components to improve endosomal escape. To minimize interference of clearance by non-targeted cells, especially immune cells in the acute wound microenvironment, surface charge was neutralized...
April 27, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29791750/tiled-array-based-sequencing-identifies-enrichment-of-loss-of-function-variants-in-the-highly-homologous-filaggrin-gene-in-african-american-children-with-severe-atopic-dermatitis
#8
Mary Elizabeth Mathyer, Ashley M Quiggle, X F Colin C Wong, Simon L I J Denil, Monique G Kumar, Heather M Ciliberto, Susan J Bayliss, John E Common, Cristina de Guzman Strong
Filaggrin (FLG) loss of function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD), and are often population-specific. African American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known. Discovery of FLG LOF using exome sequencing is challenging given the known difficulties for accurate short-read alignment to FLG's high homology repeat variation...
May 23, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29777949/evaluation-of-skin-or-sweat-characteristic-mrnas-for-inferring-the-human-origin-of-touched-contact-traces
#9
Tomoko Akutsu, Ken Watanabe, Ayari Takamura, Koichi Sakurada
The source of small amounts of touch DNA, which is transferred from the skin to an object when it is handled or touched, could be an issue in the forensic analysis of criminal cases. Here, we performed an extended evaluation of skin- or sweat-characteristic mRNAs to investigate their usability to infer whether an object has been handled or touched by someone. First, we compared the expression levels of candidate genes between skin swabs and other body fluids by quantitative RT-PCR analysis. Among the analyzed genes, corneodesmosin (CDSN), late cornified envelope 1C (LCE1C), filaggrin (FLG), desmocollin 1, and dermcidin were selected for further analysis on the basis of their specificities and sensitivities...
May 14, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29775025/-study-on-the-mutation-of-filaggrin-gene-in-nasal-polyps
#10
Q Zhou, W L Bai, J X Li
Objective: The aim of this study is to investigate the relationship between Filaggrin ( FLG ) gene mutations and nasal polyps. Method: Genomic DNA was extract from 48 nasal polyps tissues, and 30 samples of inferior turbinate tissues from normal human controls. Two FLG gene mutation points (R501X and 3321delA) were detected by polymerase chain reaction (PCR) first, then detected by polypropylene gel electrophoresis, and finally gene sequencing. Result: The FLG gene c. 3321delA was found in 2 cases (4.17%) of nasal polyps, both of them were heterozygous mutations...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770357/mapk-pathway-involved-in-epidermal-terminal-differentiation-of-normal-human-epidermal-keratinocytes
#11
Xianguang Meng, Liyun Qiu, Haiyan Song, Ningning Dang
Objective: To investigate the effect of mitogen-activated protein kinase (MAPK) signaling pathway in epidermal terminal differentiation. Methods: The MAPK pathways (p38, ERK1/2, JNK) were inhibited by SB203580, PD98059, and SP600125 in normal human epidermal keratinocytes (NHEKs), respectively. Western blotting assays were performed to detect expression of filaggrin and differentiation-related proteins. The mRNA expressions of differentiation-related proteins were detected by real-time quantitative PCR (qRT-PCR)...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29762208/prevalence-of-atopic-dermatitis-and-pattern-of-drug-therapy-in-malaysian-children
#12
Yi-Yeong Goh, Fazlollah Keshavarzi, Yik Ling Chew
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing, noncontagious skin inflammation characterized by dry skin and itch. Mutation in filaggrin gene leads to defective skin barrier, allowing entry of allergen and eliciting immunological response. OBJECTIVES: The aims of this study were to investigate the prevalence of AD in Malaysian children and to understand the pattern of drug therapy. Such information could be useful to establish the relationship between ethnicity and family history of atopy and the development of associated signs and symptoms...
May 2018: Dermatitis
https://www.readbyqxmd.com/read/29758285/filaggrin-2-deficiency-results-in-abnormal-cell-cell-adhesion-in-the-cornified-cell-layers-and-causes-peeling-skin-syndrome-type-a
#13
Janan Mohamad, Ofer Sarig, Lisa M Godsel, Alon Peled, Natalia Malchin, Ron Bochner, Dan Vodo, Tom Rabinowitz, Mor Pavlovsky, Shahar Taiber, Maya Fried, Marina Eskin-Schwartz, Siwar Assi, Noam Shomron, Jouni Uitto, Jennifer L Koetsier, Reuven Bergman, Kathleen J Green, Eli Sprecher
Peeling skin syndromes form a large and heterogeneous group of inherited disorders characterized by superficial detachment of the epidermal cornified cell layers, often associated with inflammatory features. Here we report on a consanguineous family featuring non-inflammatory peeling of the skin exacerbated by exposure to heat and mechanical stress. Whole exome sequencing revealed a homozygous nonsense mutation in FLG2, encoding filaggrin 2, which co-segregated with the disease phenotype in the family. The mutation was found to result in decreased FLG2 RNA levels as well almost total absence of filaggrin 2 in the patient epidermis...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29750772/the-ins-and-outs-of-an-outside-in-view-of-allergies-atopic-dermatitis-and-allergy-prevention
#14
Marcus Shaker, Robert G P Murray, Julianne A Mann
PURPOSE OF REVIEW: The skin barrier is a dynamic innate immune organ. This review summarizes the current understanding of how deficiencies associated with atopic dermatitis invite other atopic disorders of the allergic march. RECENT FINDINGS: Atopic dermatitis is characterized by skin barrier defects (such as mutations in filaggrin), intrinsic proallergic T-helper cell 2 immune dysregulation, and skin microbiome alterations. These factors promote the development of food allergy and asthma...
May 9, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29746170/filaggrin-and-tight-junction-proteins-are-crucial-for-il-13-mediated-esophageal-barrier-dysfunction
#15
Liping Wu, Tadayuki Oshima, Min Li, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
Eosinophilic esophagitis (EoE) is an allergy-mediated disease that is accompanied by IL-13 overexpression and an impaired esophageal barrier. Filaggrin (FLG) and tight junction (TJ) proteins are considered to contribute to epithelial barrier function. However, their functional involvement in EoE has not been elucidated. Here, we aimed to determine the IL-13-mediated barrier dysfunction and expression of TJ-related proteins in EoE, and to characterize interactions among TJ-related proteins involved in the barrier function of the esophageal epithelium...
May 10, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29736291/optimization-of-cytokine-milieu-to-reproduce-atopic-dermatitis-related-gene-expression-in-hacat-keratinocyte-cell-line
#16
Hee Joo Kim, Jinok Baek, Jong Rok Lee, Joo Young Roh, YunJae Jung
Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine milieu required for accurate reproduction of AD-related gene expression profile in vitro , we evaluated the expression pattern of CCL22 , CCL17 , IL5 , IL13 , IL33 , IL25 , TSLP , FLG , and LOR in human lesional AD skin and cytokine-stimulated HaCaT cells. An increase in Th2 mediators ( IL5 , IL13 , CCL22 , CCL17, IL25 , IL33 , and TSLP ) and a decrease in genes related to cornified cell envelope (filaggrin and loricrin) were observed in human AD lesions...
April 2018: Immune Network
https://www.readbyqxmd.com/read/29719469/the-skin-protective-effects-of-compound-k-a-metabolite-of-ginsenoside-rb1-from-panax-ginseng
#17
Eunji Kim, Donghyun Kim, Sulgi Yoo, Yo Han Hong, Sang Yun Han, Seonggu Jeong, Deok Jeong, Jong-Hoon Kim, Jae Youl Cho, Junseong Park
Background: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng . There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. Methods: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29691836/early-life-regional-and-temporal-variation-in-filaggrin-derived-natural-moisturising-factor-filaggrin-processing-enzyme-activity-corneocyte-phenotypes-and-plasmin-activity-implications-for-atopic-dermatitis
#18
M A McAleer, I Jakasa, N Raj, C P F O'Donnell, M E Lane, A V Rawlings, R Voegeli, W H I McLean, S Kezic, A D Irvine
BACKGROUND: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products (natural moisturising factors, NMF), activities of filaggrin processing enzymes (bleomycin hydrolase; BH and calpain-1; C-1) and plasmin, and corneocyte envelope (CE) maturity in early life are largely unknown. OBJECTIVES: We did a cross-sectional, observational study investigating regional and age dependent variations in NMF levels, activity of proteases and CE maturity in stratum corneum (SC) from infants to determine if these could explain the observed predilection sites for AD in early life...
April 25, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29691121/stabilization-of-microtubules-restores-barrier-function-after-cytokine-induced-defects-in-reconstructed-human-epidermis
#19
Chiung-Yueh Hsu, Nicolas Lecland, Valérie Pendaries, Cécile Viodé, Daniel Redoulès, Carle Paul, Andreas Merdes, Michel Simon, Christiane Bierkamp
BACKGROUND: A variety of human skin disorders is characterized by defects in the epidermal barrier, leading to dehydration, itchiness, and rashes. Previously published literature suggests that microtubule stabilization at the cortex of differentiating keratinocytes is necessary for the formation of the epidermal barrier. OBJECTIVES: We tested whether stabilization of microtubules with paclitaxel or epothilone B can repair barrier defects that were experimentally induced in three-dimensional culture models of epidermis...
April 18, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29687476/peptidylarginine-deiminase-is-involved-in-maintaining-the-cornified-oral-mucosa-of-rats
#20
S Arita, M Hatta, K Uchida, T Kita, K Okamura, T Ryu, H Murakami, R Sakagami, J Yamazaki
BACKGROUND AND OBJECTIVE: Epithelial cells derived from different regions exhibit marked differences in their differentiation capacity, allowing them to provide a suitable protective barrier. We aimed to clarify the role of peptidylarginine deiminase (PAD) in modifying the key epidermal proteins filaggrin (FLG) and keratin 1 (K1) during stratification of the rat palate and buccal mucosa. MATERIAL AND METHODS: We performed immunofluorescence, immunoblotting, PAD activity assays and 2-dimensional electrophoresis, and developed an organotypic culture model...
April 23, 2018: Journal of Periodontal Research
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