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https://www.readbyqxmd.com/read/29676818/new-insights-into-the-phenotypes-of-atopic-dermatitis-linked-with-allergies-and-asthma-in-children-an-overview
#1
F Amat, A Soria, P Tallon, M Bourgoin-Heck, N Lambert, A Deschildre, J Just
Atopic dermatitis (AD) is a complex disease with multiple causes and complex mechanistic pathways according to age of onset, severity of the illness, ethnic modifiers, response to therapy, and triggers. A group of difficult-to-manage patients characterized by early-onset AD and severe lifelong disease associated with allergic asthma and/or food allergy, has been identified. In this paper, we focus on these severe phenotypes, analyzing their links with other atopic comorbidities, and taking into account the results from recent cohort studies and meta-analyses...
April 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29676067/significance-of-skin-barrier-dysfunction-in-atopic-dermatitis
#2
REVIEW
Byung Eui Kim, Donald Y M Leung
The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Skin barrier dysfunction is the initial step in the development of AD. Multiple factors, including immune dysregulation, filaggrin mutations, deficiency of antimicrobial peptides, and skin dysbiosis contribute to skin barrier defects...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675643/eyelash-length-for-the-diagnosis-of-atopic-dermatitis-and-ichthyosis-vulgaris-in-children-a-case-control-study
#3
Mehak Singh, Manoj Pawar
Eyelash trichomegaly (ET) is increased length (≥ 12 mm), curling, pigmentation, or thickness of eyelashes. Among acquired causes, allergic diseases and atopic dermatitis (AD) have been found to be associated with eyelash trichomegaly especially in children; however, to date, this claim has not been studied in detail. To compare the eyelash lengths of AD and ichthyosis vulgaris (IV) patients with those of age- and sex-matched patients with unrelated skin disorders, we measured (with a digital Vernier caliper) and compared the eyelash lengths of AD (n = 58) and IV (n = 31) patients to those of age- and sex-matched patients with unrelated skin disorders (n = 178)...
April 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29628436/the-rheumatoid-arthritis-associated-citrullinome
#4
Ronak Tilvawala, Son Hong Nguyen, Aaron J Maurais, Venkatesh V Nemmara, Mitesh Nagar, Ari J Salinger, Sunil Nagpal, Eranthie Weerapana, Paul R Thompson
Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti-citrullinated protein antibodies (ACPAs) which are used to diagnose RA. ACPA-recognizing citrullinated enolase, vimentin, keratin, and filaggrin are also pathogenic. Here, we used a chemoproteomic approach to define the RA-associated citrullinome. The identified proteins include numerous serine protease inhibitors (Serpins), proteases and metabolic enzymes...
March 21, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29625778/-the-epidermal-barrier
#5
R Abdayem, M Haftek
The skin acts as an interface between the body and its surrounding environment. The epidermis, the surface layer of the skin, is chiefly responsible for this interactive protective function. The epidermal barrier may be subdivided into three defensive systems: the photoprotective barrier, the immune barrier, and the physical and chemical barrier of the stratum corneum or horny layer. To protect against harmful ultraviolet radiation, the epidermis has absorption factors such as melanin, produced by melanocytes, and urocanic acid, which is a degradation product of filaggrin...
April 3, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29604251/atopic-dermatitis-subjects-colonized-with-staphylococcus-aureus-have-a-distinct-phenotype-and-endotype
#6
Eric L Simpson, Miguel Villarreal, Brett Jepson, Nick Rafaels, Gloria David, Jon Hanifin, Patricia Taylor, Mark Boguniewicz, Takeshi Yoshida, Anna De Benedetto, Kathleen C Barnes, Donald Y M Leung, Lisa A Beck
Atopic dermatitis (AD) patients are commonly colonized with Staphylococcus aureus (ADS.aureus+) but what differentiates this group from noncolonized AD subjects (ADS.aureus-) has not been well-studied. To evaluate whether these two groups have unique phenotypic or endotypic features we performed a multi-center, cross-sectional study enrolling ADS.aureus+ (N=51) and ADS.aureus- (N=45) subjects defined by the presence or absence of S. aureus by routine culture techniques and nonatopic, noncolonized controls NAS...
March 28, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29599666/structure-and-function-of-the-epidermal-barrier-in-patients-with-atopic-dermatitis-treatment-options-part-one
#7
REVIEW
Jagoda Pelc, Magdalena Czarnecka-Operacz, Zygmunt Adamski
Atopic dermatitis is a chronic, recurrent inflammatory skin disease, which is frequently familial. The main cause of the disease seems to be a defect of the epidermal barrier resulting from a genetic predisposition concerning the epidermis, functioning of the immune system as well as environmental factors (which are not related to the immune system). Genes responsible for encoding protein S100, filaggrin, proteases and their inhibitors are the main genes related to the problem of epidermal barrier dysfunction...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29545605/orchestrated-control-of-filaggrin-actin-scaffolds-underpins-cornification
#8
Danuta Gutowska-Owsiak, Jorge Bernardino de La Serna, Marco Fritzsche, Aishath Naeem, Ewa I Podobas, Michael Leeming, Huw Colin-York, Ryan O'Shaughnessy, Christian Eggeling, Graham S Ogg
Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier. Cornification is dynamically controlled by the protein filaggrin, rapidly released from keratohyalin granules (KHGs). However, the mechanisms of cornification largely remain elusive, partly due to limitations of the observation techniques employed to study filaggrin organization in keratinocytes. Moreover, while the abundance of keratins within KHGs has been well described, it is not clear whether actin also contributes to their formation or fate...
March 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29540642/dual-factors-may-be-necessary-for-development-of-atopic-march-in-early-infancy
#9
Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Masaya Takahashi, Hirotaka Minami
The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29528494/the-il-13-periostin-il-24-pathway-causes-epidermal-barrier-dysfunction-in-allergic-skin-inflammation
#10
Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Masahiro Ogawa, Tomohito Yoshihara, Miho Masuoka, Gaku Tsuji, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Simon J Conway, Masutaka Furue, Kenji Izuhara
BACKGROUND: Barrier dysfunction is an important feature of atopic dermatitis (AD) in which IL-4 and IL-13, signature type 2 cytokines, are involved. Periostin, a matricellular protein induced by IL-4 or IL-13, plays a crucial role in the onset of allergic skin inflammation, including barrier dysfunction. However, it remains elusive how periostin causes barrier dysfunction downstream of the IL-13 signal. METHODS: We systematically identified periostin-dependent expression profile using DNA microarrays...
March 12, 2018: Allergy
https://www.readbyqxmd.com/read/29520873/beyond-the-physico-chemical-barrier-glycerol-and-xylitol-markedly-yet-differentially-alter-gene-expression-profiles-and-modify-signalling-pathways-in-human-epidermal-keratinocytes
#11
Edit Páyer, Judit Szabó-Papp, Lídia Ambrus, Attila Gábor Szöllősi, Mónika Andrási, Shabtay Dikstein, Lajos Kemény, István Juhász, Andrea Szegedi, Tamás Bíró, Attila Oláh
Polyols (e.g. glycerol, xylitol) are implicated as moisturizers of the skin and other epithelial tissues. However, we lack information about their exact cellular mechanisms and their effects on the gene expression profiles. Therefore, in this study, we aimed at investigating the effects of glycerol and xylitol on human epidermal keratinocytes. The polyols (identical osmolarities; xylitol: 0.0045%-0.45%; glycerol: 0.0027%-0.27%) did not alter cellular viability or intracellular calcium concentration. However, they exerted differential effects on the expression of certain genes and signalling pathways...
March 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29512781/keratin-5-14%C3%A2-mediated-cell-differentiation-and-transformation-are-regulated-by-tap63-and-notch%C3%A2-1-in-oral-squamous-cell-carcinoma%C3%A2-derived-cells
#12
Saumya S Srivastava, Hunain Alam, Sonam J Patil, Rashmi Shrinivasan, Sweta Raikundalia, Pratik Rajeev Chaudhari, Milind M Vaidya
Keratins 5/14 (K5/14) are intermediate filament proteins expressed in the basal layer of stratified epithelial cells and are known targets of p63. Previous research in our laboratory showed that upon K5/14 downregulation in oral squamous cell carcinoma (OSCC)‑derived cells, there was an increase in intracellular Notch‑1 levels and differentiation markers such as involucrin, keratin 1 and a decrease in tumorigenic potential in vivo. However, the molecules involved in the K14 regulated cell differentiation and transformation are not known to date...
March 6, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29512138/changes-in-filaggrin-degradation-products-and-corneocyte-surface-texture-by-season
#13
K A Engebretsen, S Kezic, C Riethmüller, J Franz, I Jakasa, A Hedengran, A Linneberg, J D Johansen, J P Thyssen
BACKGROUND: During the winter in northern countries, the risk of dermatitis is increased due to low temperature and humidity. Dermatitis is particularly common on weather-exposed skin such as the cheeks and hands. Recently, increased numbers of unidentified nanosized protrusions on the corneocyte surface were associated with dermatitis and deficiency of natural moisturizing factor (NMF). OBJECTIVES: To investigate the effect of season on NMF levels and corneocyte surface texture in cheek and hand skin of healthy adults...
March 7, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29509988/capsaicin-induces-atopic-dermatitis-like-manifestations-through-dysregulation-of-proteolytic-system-and-alteration-of-filaggrin-processing-in-rats
#14
Sewon Kim, Seung Keun Back, Heung Sik Na, Sun-Ho Kee
Atopic dermatitis (AD) is a complex disease featuring pruritic skin inflammation. Many animal models have been developed. In a rat model, subcutaneous capsaicin injection within 48 hours after birth induces AD-like skin manifestations of dermatitis and scratching behavior 3 weeks after the injection. When 2-4-week-old rats were injected with capsaicin, the lag period was shortened and the severity of skin manifestations was significantly reduced, suggesting influences of postnatal development. Lgr6 is an epidermal stem cell marker that is normally restricted to the isthmus area of hair follicles at postnatal 2 weeks...
March 6, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29507996/prognosis-of-preschool-eczema-and-factors-of-importance-for-remission
#15
Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Erik Melén, Samina Asad, Maria Bradley, Agne Liedén, Natalia Ballardini, Carl-Fredrik Wahlgren
Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age. In multivariate prognostic models, persistent preschool eczema (eczema at 1, 2 and 4 years of age) (odds ratio 0.27 (95% confidence interval 0.18-0.41)), preschool eczema with sleep disturbance (due to itch at least once a week at 1, 2 and/or 4 years of age) (0...
March 2, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29500077/protective-role-of-6-formylindolo-3-2-b-carbazole-ficz-an-endogenous-ligand-for-arylhydrocarbon-receptor-in-chronic-mite-induced-dermatitis
#16
Mari Kiyomatsu-Oda, Hiroshi Uchi, Saori Morino-Koga, Masutaka Furue
BACKGROUND: Chronic eczema such as atopic dermatitis imposes significant socio-econo-psychologic burdens on the affected individuals. In addition to conventional topical treatments, phototherapy is recommended for patients with extensive lesions. Although immunosuppression is believed to explain its primary effectiveness, the underlying mechanisms of phototherapy remain unsolved. Ultraviolet irradiation generates various tryptophan photoproducts including 6-formylindolo[3,2-b]-carbazole (FICZ)...
February 21, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29487382/antibodies-to-a-strain-specific-citrullinated-epstein-barr-virus-peptide-diagnoses-rheumatoid-arthritis
#17
Nicole Hartwig Trier, Bettina Eide Holm, Julie Heiden, Ole Slot, Henning Locht, Hanne Lindegaard, Anders Svendsen, Christoffer Tandrup Nielsen, Søren Jacobsen, Elke Theander, Gunnar Houen
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Anti-citrullinated protein antibodies (ACPA) are crucial for the serological diagnosis of RA, where Epstein-Barr virus (EBV) has been suggested to be an environmental agent in triggering the onset of the disease. This study aimed to analyse antibody reactivity to citrullinated EBV nuclear antigen-2 (EBNA-2) peptides from three different EBV strains (B95-8, GD1 and AG876) using streptavidin capture enzyme-linked immunosorbent assay. One peptide, only found in a single strain (AG876), obtained a sensitivity and specificity of 77% and 95%, respectively and showed high sequence similarity to the filaggrin peptide originally used for ACPA detection...
February 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29485689/effect-of-atopic-skin-stressors-on-natural-moisturizing-factors-and-cytokines-in-healthy-adult-epidermis
#18
K A Engebretsen, S Kezic, I Jakasa, A Hedengran, A Linneberg, L Skov, J D Johansen, J P Thyssen
BACKGROUND: Epidermal deficiency of filaggrin, and the derived natural moisturizing factors (NMF), is associated with increased risk of atopic dermatitis (AD). While filaggrin gene mutations cause filaggrin deficiency, there is limited insight in causative environmental factors. OBJECTIVE: To explore the effect of selected exogenous skin stressors on NMF and skin cytokines levels in healthy adult epidermis. MATERIAL AND METHODS: 40 healthy volunteers (18-49 years) were exposed to hard, soft, and chlorinated water, 0...
February 27, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29484729/pinus-densiflora-bark-extract-ameliorates-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-in-nc-nga-mice-by-regulating-th1-th2-balance-and-skin-barrier-function
#19
Jun Woo Lee, Qianwen Wu, Young Pyo Jang, Se Young Choung
Korean red pine (Pinus densiflora) bark has been traditionally used in Korea and other parts of East Asia to relieve inflammatory diseases. Although many studies using P. densiflora bark have been reported, its effect on atopic dermatitis (AD) has not been elucidated. Thus, we investigated whether the P. densiflora bark extract (PBE) has potential to attenuate AD symptoms and elucidated the molecular mechanism. Oral administration of PBE to mice with 2,4-dinitrochlorobenzene (DNCB)-induced AD lessened dermatitis scores and scratching behavior and significantly reduced measures of epidermal thickness, infiltration of mast cells and eosinophils, levels of immunoglobulin E (IgE), and IgG1 /IgG2a ratio in serum...
February 27, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29475513/single-blinded-randomized-placebo-controlled-study-on-the-effects-of-ciclosporin-on-cutaneous-barrier-function-and-immunological-response-in-atopic-beagles
#20
Amelia G White, Domenico Santoro, Kim Ahrens, Rosanna Marsella
Ciclosporin (CsA) is a common treatment for canine atopic dermatitis (cAD). cAD is a very common skin disease with a multifactorial pathogenesis due to complex interactions between the host and the environment. The purpose of this study was to describe the physical and immunological effects of CsA in cAD using a canine model of AD. Fourteen beagles were enrolled; seven received CsA orally every 24 h for 28 days, and seven received placebo. All dogs were exposed to relevant allergens, house dust mite solution, one day prior to treatment and once weekly thereafter for 28 consecutive days...
March 2018: Veterinary Immunology and Immunopathology
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