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Filaggrin

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https://www.readbyqxmd.com/read/28644349/filaggrin-and-periostin-expression-is-altered-in-eosinophilic-esophagitis-and-normalized-with-treatment
#1
Ekaterini Politi, Aspasia Angelakopoulou, Dimitra Grapsa, Maria Zande, Kalliopi Stefanaki, Ioanna Panagiotou, Eleftheria Roma, Ekaterini Syrigou
OBJECTIVES: Previous data have suggested that filaggrin (FLG) and periostin (POSTN) genes may be dysregulated in eosinophilic esophagitis (EoE). We aimed to further evaluate the expression patterns of FLG and POSTN proteins in esophageal tissue samples of patients with EoE, as compared to those of patients with gastroesophageal reflux disease (GERD) and normal controls. METHODS: A total of 61 prospectively collected cases, including 40 children with EoE and 21 children with GERD, and a control group of 14 sex- and age-matched healthy children were enrolled...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28628158/-effects-of-ptch1-mutations-on-the-epithelial-proliferation-derived-from-keratocystic-odontogenic-tumour
#2
(no author information available yet)
OBJECTIVE: To explore the relationship between the PTCH1 mutation and the expression of bcl-2, filaggrin, and loricrin in the keratocystic odontogenic tumour (KCOT), as well as the effects of the mutated PTCH1 on the epithelial proliferation and differentiation. METHODS: The samples were collected from 20 cases of KCOT with mutated PTCH1, as well as 20 cases without mutation. All the samples were analyzed with immunohistochemical staining, for the purpose of investigating the expression of bcl-2, filaggrin, and loricrin...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28615416/il-17-receptor-a-maintains-and-protects-the-skin-barrier-to-prevent-allergic-skin-inflammation
#3
Achilleas Floudas, Sean P Saunders, Tara Moran, Christian Schwartz, Emily Hams, Denise C Fitzgerald, James A Johnston, Graham S Ogg, Andrew N McKenzie, Patrick T Walsh, Padraic G Fallon
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although type 2 responses are implicated in AD, emerging evidence indicates a potential role for the IL-17A signaling axis in AD pathogenesis. In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA deficiency (Il17ra(-/-) ) resulted in severe exacerbation of skin inflammation. Interestingly, Il17ra(-/-) mice without the filaggrin mutation also developed spontaneous progressive skin inflammation with eosinophilia, as well as increased levels of thymic stromal lymphopoietin (TSLP) and IL-5 in the skin...
June 14, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28603906/atopic-skin-in-vivo-raman-identification-of-global-molecular-signature-a-comparative-study-with-healthy-skin
#4
L Verzeaux, R Vyumvuhore, D Boudier, M Le Guillou, S Bordes, M Essendoubi, M Manfait, B Closs
Atopic dermatitis (AD) is the most common skin inflammatory disease, affecting up to 3% of adults and 20% of children. Skin barrier impairment is thought to be the primary factor in this disease. Currently, there is no method proposed to monitor non-invasively the different molecular disorders involved in the upper layer of AD skin. Raman microspectroscopy has proved to be a powerful tool to characterize some AD molecular descriptors such as lipid content, global hydration level, filaggrin and its derivatives...
June 11, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28600081/a-daily-skincare-regimen-with-a-unique-ceramide-and-filaggrin-formulation-rapidly-improves-chronic-xerosis-pruritus-and-quality-of-life-in-older-adults
#5
Anne Lynn S Chang, Suephy C Chen, Lars Osterberg, Staci Brandt, Erika C von Grote, Matthew H Meckfessel
A skin care regimen which significantly improved atopic dermatitis and pruritus was evaluated for its efficacy and acceptability in senior subjects diagnosed with xerosis who also suffer from pruritus. This was an open-label, single-center study, designed to evaluate the daily use of a skin care regimen for 15 days. Assessments were made at baseline, day 8 and day 15 for visual skin dryness, transepidermal water loss (TEWL), hydration, desquamation, subject-perceived itch and quality of life (QoL). Twenty-five subjects, ages 60-73 years, had significantly improved skin visual dryness, hydration, desquamation, itch and QoL at days 8 and 15, relative to baseline (P < ...
June 6, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28583294/hataedock-treatment-has-preventive-therapeutic-effects-for-atopic-dermatitis-through-skin-barrier-protection-in-dermatophagoides-farinae-induced-nc-nga-mice
#6
Ho-Yeol Cha, Sang-Hyun Ahn, Jin-Hong Cheon, Sun-Young Park, Kibong Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Hataedock treatment is traditionally used for the purpose of preventing the future skin disease by feeding herbal extracts to the newborn in traditional Chinese and Korean medicine. AIM OF THE STUDY: This study investigated the preventive therapeutic effects of Hataedock (HTD) treatment for atopic dermatitis (AD) through skin barrier protection in Dermatophagoides farinae-induced NC/Nga mice. MATERIALS AND METHODS: To the HTD treatment group, the extract of Coptis japonica Makino and Glycyrrhiza uralensis Fischer, which analyzed with High Performance Liquid Chromatography (HPLC)-fingerprint for quality consistency, was administered orally to the 3-week-old mice before inducing AD...
June 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28569792/loss-of-epidermal-ap1-transcription-factor-function-reduces-filaggrin-level-alters-chemokine-expression-and-produces-an-ichthyosis-related-phenotype
#7
Christina A Young, Ellen A Rorke, Gautam Adhikary, Wen Xu, Richard L Eckert
AP1 transcription factors are important controllers of epidermal differentiation. Multiple family members are expressed in the epidermis in a differentiation-dependent manner, where they function to regulate gene expression. To study the role of AP1 factor signaling, TAM67 (dominant-negative c-jun) was inducibly expressed in the suprabasal epidermis. The TAM67-positive epidermis displays keratinocyte hyperproliferation, hyperkeratosis and parakeratosis, delayed differentiation, extensive subdermal vasodilation, nuclear loricrin localization, tail and digit pseudoainhum and reduced filaggrin level...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28569788/disease-linked-connexin26-s17f-promotes-volar-skin-abnormalities-and-mild-wound-healing-defects-in-mice
#8
Eric Press, Katanya C Alaga, Kevin Barr, Qing Shao, Felicitas Bosen, Klaus Willecke, Dale W Laird
Several mutant mice have been generated to model connexin (Cx)-linked skin diseases; however, the role of connexins in skin maintenance and during wound healing remains to be fully elucidated. Here we generated a novel, viable, and fertile mouse (Cx26(CK14-S17F/+)) with the keratitis-ichthyosis-deafness mutant (Cx26S17F) driven by the cytokeratin 14 promoter. This mutant mouse mirrors several Cx26-linked human skin pathologies suggesting that the etiology of Cx26-linked skin disease indeed stems from epidermal expression of the Cx26 mutant...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28559894/multifactorial-modulation-of-food-induced-anaphylaxis
#9
REVIEW
Sara Benedé, María Garrido-Arandia, Laura Martín-Pedraza, Cristina Bueno, Araceli Díaz-Perales, Mayte Villalba
Prevalence of food-induced anaphylaxis increases progressively and occurs in an unpredictable manner, seriously affecting the quality of life of patients. Intrinsic factors including age, physiological, and genetic features of the patient as well as extrinsic factors such as the intake of drugs and exposure to environmental agents modulate this disorder. It has been proven that diseases, such as mastocytosis, defects in HLA, or filaggrin genes, increase the risk of severe allergic episodes. Certain allergen families such as storage proteins, lipid transfer proteins, or parvalbumins have also been linked to anaphylaxis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28556377/deficiency-of-filaggrin-regulates-endogenous-cysteine-protease-activity-leading-to-impaired-skin-barrier-function
#10
X W Wang, J J Wang, D Gutowska-Owsiak, M Salimi, T A Selvakumar, A Gwela, L Y Chen, Y J Wang, E Giannoulatou, G Ogg
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disorder, characterized by skin barrier defects and enhanced allergen priming. Null mutations in the filaggrin gene (FLG) are strongly associated with moderate to severe AD, but the pathways linking barrier dysfunction and cutaneous inflammation are still largely unknown. AIM: To assess alteration of endogenous cysteine protease activity in FLG-deficient keratinocytes, and to determine whether the alteration in cysteine protease activity affects epidermal barrier function and associated gene and protein expression...
May 29, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28543665/immunohistochemical-evaluation-of-epidermal-proliferation-differentiation-and-melanocytic-density-in-symmetrical-acrokeratoderma
#11
P-P Yang, J Peng, Y-Y Wu, Z Liu, P Sheng, Y Zhou, S-J Li, Y-M Fan
BACKGROUND: Symmetrical acrokeratoderma (SAK) is characterized by brown to black hyperkeratotic patches on acral regions. Although epidermal hyperkeratosis and acanthosis are consistent pathological changes, the nature of epidermal hyperplasia is unknown. AIM: To evaluate epidermal proliferation and differentiation and melanocytic density in skin lesions of SAK. METHODS: Expression of keratin 10 (K10), K14, K16, involucrin, filaggrin, Ki-67, and Melan-A was detected by immunohistochemistry in eight patients with SAK, seven patients with ichthyosis vulgaris (IV) and six healthy controls (HCs)...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28538945/purpuric-drug-eruptions-caused-by-epidermal-growth-factor-receptor-inhibitors-for-non-small-cell-lung-cancer-a-clinicopathologic-study-of-32-cases
#12
Yung-Tsu Cho, Kai-Lung Chen, Yi-Shuan Sheen, Che-Wen Yang, Jau-Yu Liau, Yu-Pin Cheng, Chia-Yu Chu
Importance: Purpuric skin lesions have only rarely been reported in patients receiving epidermal growth factor receptor inhibitors. However, their clinical and histopathologic presentations have varied considerably. Objective: To characterize purpuric skin eruptions caused by epidermal growth factor receptor inhibitors. Design, Setting, and Participants: This prospective study enrolled 32 patients who presented to an integrated dermato-oncologic clinic in a tertiary referral medical center with purpuric skin lesions after using epidermal growth factor receptor inhibitors from January 1, 2013, through December 31, 2015...
May 24, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28527695/cytoprotection-proliferation-and-epidermal-differentiation-of-adipose-tissue-derived-stem-cells-on-emu-oil-based-electrospun-nanofibrous-mat
#13
Younes Pilehvar-Soltanahmadi, Mohammad Nouri, Mikaël M Martino, Amir Fattahi, Effat Alizadeh, Masoud Darabi, Mohammad Rahmati-Yamchi, Nosratollah Zarghami
Electrospun nanofibrous scaffolds containing natural substances with wound healing properties such as Emu oil (EO) may have a great potential for increasing the efficiency of stem cell-based skin bioengineering. For this purpose, EO blended PCL/PEG electrospun nanofibrous mats were successfully fabricated and characterized using FE-SEM, FTIR and Universal Testing Machine. The efficiency of the scaffolds in supporting the adherence, cytoprotection, proliferation and differentiation of adipose tissue-derived stem cells (ADSCs) to keratinocyte was evaluated...
May 17, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28526300/embryonic-ap1-transcription-factor-deficiency-causes-a-collodion-baby-like-phenotype
#14
Christina A Young, Richard L Eckert, Gautam Adhikary, Debra Crumrine, Peter M Elias, Miroslav Blumenberg, Ellen A Rorke
AP1 transcription factors are important controllers of gene expression in the epidermis, and altered AP1 factor function can perturb keratinocyte proliferation and differentiation. However, our understanding of how AP1 signaling changes may underlie or exacerbate skin disease is limited. We have shown that inhibiting AP1 factor function in suprabasal adult epidermis leads to reduced filaggrin levels and to a phenotype that resembles the genetic disorder, ichthyosis vulgaris. We now show that inhibiting AP1 factor function during development in embryonic epidermis produces marked phenotypic changes including reduced filaggrin mRNA and protein levels, compromised barrier function, marked ultrastructural change and enhanced dehydration susceptibility that resembles the phenotype observed in the flaky tail mouse, a model for ichthyosis vulgaris...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28525834/exposure-to-phenols-parabens-and-uv-filters-associations-with-loss-of-function-mutations-in-the-filaggrin-gene-in-men-from-the-general-population
#15
Ulla N Joensen, Niels Jørgensen, Jacob P Thyssen, Jørgen Holm Petersen, Pal B Szecsi, Steen Stender, Anne-Maria Andersson, Niels E Skakkebæk, Hanne Frederiksen
BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could have increased trans-epidermal penetration of other chemicals. OBJECTIVES: We investigated exposure to non-persistent chemicals in young Danish men with and without FLG mutations...
May 16, 2017: Environment International
https://www.readbyqxmd.com/read/28522399/anti-allergic-and-profilaggrin-proflg-mrna-expression-modulatory-effects-of-sacran
#16
Nlandu R Ngatu, Keiichi Motoyama, Yasumitsu Nishimura, Maiko Kaneko Okajima, Ryoji Hirota, Taishi Higashi, Suni Lee, Hidetoshi Arima, Mitsunori Ikeda, Sayumi Nojima, Tatsuo Kaneko
Atopic dermatitis (AD) is a skin disorder characterized by filaggrin (FLG) defect. We evaluated sacran's effects on dust-mite extracts (DME)-induced AD-like disease and also its effect on profilaggrin (proFLG) in a murine model of 2,4-dinitroflurobenze (DNFB)-induced contact hypersensitivity. In the murine AD-like disease model, allergic NC/Nga mice (N=60) were randomly divided into five treatment groups of 12 animals each: 0.2% and 1%sacran; 0.1% Tacrolimus; Vaseline and buffer-treated controls. Blood samples were drawn and serum levels of representative Th-1, Th-2 and also Th-17 (IL-17A) cytokines were assayed by Cytometric Bead Array (CBA)...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28516256/-skin-diseases-associated-with-environmental-factors
#17
REVIEW
Vera Mahler
BACKGROUND: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVES: Provide an overview of non-allergic skin diseases associated with environmental factors. MATERIALS AND METHODS: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. RESULTS: Predisposition (constitution e...
June 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28502108/expression-of-the-filaggrin-gene-in-umbilical-cord-blood-predicts-eczema-risk-in-infancy-a-birth-cohort-study
#18
Ali H Ziyab, Susan Ewart, Gabrielle A Lockett, Hongmei Zhang, Hasan Arshad, John W Holloway, Wilfried Karmaus
BACKGROUND: Filaggrin gene (FLG) expression, particularly in the skin, has been linked to the development of the skin barrier and is associated with eczema risk. However, knowledge as to whether FLG expression in umbilical cord blood (UCB) is associated with eczema development and prediction is lacking. OBJECTIVE: This study sought to assess whether FLG expression in UCB associates with and predicts the development of eczema in infancy. METHODS: Infants enrolled in a birth cohort study (n = 94) were assessed for eczema at ages 3-, 6-, and 12-months...
May 14, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28479159/proteomic-analysis-of-filaggrin-deficiency-identifies-molecular-signatures-characteristic-of-atopic-eczema
#19
Martina S Elias, Heather A Long, Carla F Newman, Paul A Wilson, Andrew West, Paul J McGill, Keith C Wu, Michael J Donaldson, Nick J Reynolds
BACKGROUND: Atopic eczema (AE) is characterized by skin barrier and immune dysfunction. Null mutations in filaggrin (FLG), a key epidermal barrier protein, strongly predispose to AE; however, the precise role of FLG deficiency in AE pathogenesis remains incompletely understood. OBJECTIVES: We sought to identify global proteomic changes downstream of FLG deficiency in human epidermal living skin-equivalent (LSE) models and validate findings in skin of patients with AE...
April 28, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28465560/increased-cis-to-trans-urocanic-acid-ratio-in-the-skin-of-chronic-spontaneous-urticaria-patients
#20
Duy Le Pham, Kyung-Min Lim, Kyung-Mi Joo, Hae-Sim Park, Donald Y M Leung, Young-Min Ye
Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 healthy normal controls (NCs) and measured contents of FBPs (pyrrolidone carboxylic acid [PCA] and urocanic acid [UCA]) using UPLC-MS/MS, transepidermal water loss (TEWL) and epidermal pH. Compared to NCs, cis-UCA level was increased in CSU lesions (P < 0...
May 2, 2017: Scientific Reports
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