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https://www.readbyqxmd.com/read/29228020/transplantation-of-canine-olfactory-ensheathing-cells-producing-chondroitinase-abc-promotes-chondroitin-sulphate-proteoglycan-digestion-and-axonal-sprouting-following-spinal-cord-injury
#1
Darren Carwardine, Jonathan Prager, Jacob Neeves, Elizabeth M Muir, James Uney, Nicolas Granger, Liang-Fong Wong
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix of the glial scar can inhibit efficient axonal repair and limit the therapeutic potential of OECs. Here we have used lentiviral vectors to genetically modify canine OECs to continuously deliver mammalian chondroitinase ABC at the lesion site in order to degrade the inhibitory chondroitin sulphate proteoglycans in a rodent model of spinal cord injury...
2017: PloS One
https://www.readbyqxmd.com/read/29227494/the-crucial-role-of-a-spacer-material-on-the-efficiency-of-charge-transfer-processes-in-organic-donor-acceptor-junction-solar-cells
#2
Reed Nieman, Hsinhan Tsai, Wanyi Nie, Adelia J A Aquino, Aditya D Mohite, Sergei Tretiak, Hao Li, Hans Lischka
Organic photovoltaic donor-acceptor junction devices composed of π-conjugated polymer electron donors (D) and fullerene electron acceptors (A) show greatly increased performance when a spacer material is inserted between the two layers (W. Y. Nie, G. Gupta, B. K. Crone, F. L. Liu, D. L. Smith, P. P. Ruden, C. Y. Kuo, H. Tsai, H. L. Wang, H. Li, S. Tretiak and A. D. Mohite, Adv. Sci., 2015, 2, 1500024.). For instance, experimental results reveal significant improvement of photocurrent when a terthiophene oligomer derivative is inserted in between π-conjugated poly(3-hexylthiophene-2,5-diyl) (P3HT) donor and C60 acceptor...
December 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29227178/neuronal-pathophysiology-featuring-prpc-and-its-control-over-ca2-metabolism
#3
Alessandro Bertoli, M Catia Sorgato
Calcium (Ca2+) is an intracellular second messenger that ubiquitously masters remarkably diverse biological processes, including cell death. Growing evidence substantiates an involvement of the prion protein (PrPC) in regulating neuronal Ca2+ homeostasis, which could rationalize most of the wide range of functions ascribed to the protein. We have recently demonstrated that PrPC controls extracellular Ca2+ fluxes, and mitochondrial Ca2+ uptake, in neurons stimulated with glutamate (De Mario et al., J Cell Sci 2017; 130:2736-46), suggesting that PrPC protects neurons from threatening Ca2+ overloads and excitotoxicity...
December 11, 2017: Prion
https://www.readbyqxmd.com/read/29226126/prevalence-of-autonomic-dysreflexia-in-patients-with-spinal-cord-injury-above-t6
#4
Eun Sun Lee, Min Cheol Joo
Objective: To investigate the prevalence of autonomic dysreflexia (AD) using ambulatory blood pressure monitoring (ABPM) and the autonomic dysfunction following spinal cord injury (ADFSCI) questionnaire in patients with spinal cord injury (SCI) above T6. Methods: Twenty-eight patients diagnosed with SCI above T6 were enrolled. ABPM and ADFSCI were utilized to assess AD. Using ABPM, systolic blood pressure (SBP), diastolic blood pressure, and heart rate (HR) were measured at 30-minute intervals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225489/on-stochastic-differential-equations-with-arbitrarily-slow-convergence-rates-for-strong-approximation-in-two-space-dimensions
#5
Máté Gerencsér, Arnulf Jentzen, Diyora Salimova
In a recent article (Jentzen et al. 2016 Commun. Math. Sci.14, 1477-1500 (doi:10.4310/CMS.2016.v14.n6.a1)), it has been established that, for every arbitrarily slow convergence speed and every natural number d∈{4,5,…}, there exist d-dimensional stochastic differential equations with infinitely often differentiable and globally bounded coefficients such that no approximation method based on finitely many observations of the driving Brownian motion can converge in absolute mean to the solution faster than the given speed of convergence...
November 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29225161/self-efficacy-and-pressure-ulcer-prevention-after-spinal-cord-injury-results-from-a-nationwide-community-survey-in-switzerland-swisci
#6
Kerstin Hug, Caroline Stumm, Isabelle Debecker, Carolina Saskia Fellinghauer, Claudio Peter, Magret Hund-Georgiadis
BACKGROUND: Pressure ulcers (PUs) are a common and severe health condition in persons with spinal cord injury (SCI). Skin-care strategies for PU prevention are usually provided during first rehabilitation. However, individuals with SCI often do not perform these strategies continuously, especially after discharge. The influence of psychological factors such as general self-efficacy (GSE) on the performance of PU prevention behavior has not yet been sufficiently explored. OBJECTIVE: To investigate if persons with higher levels of GSE are more likely to perform skin-care strategies for PU prevention regularly...
December 7, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29224176/validation-of-a-method-for-estimating-energy-expenditure-during-walking-in-middle-aged-adults
#7
Nathan Caron, Teddy Caderby, Nicolas Peyrot, Chantal Verkindt, Georges Dalleau
PURPOSE: The aim of this study was to test the validity of a method using an inertial measurement unit for estimating activity-related energy expenditure (AEE) during walking in middle-aged adults. METHODS: Twenty healthy middle-aged participants completed different treadmill walking trials with an inertial measurement unit adhered to their lower back. Gas exchange was monitored with indirect calorimetry. Mechanical data were used to estimate AEE from an algorithm developed by Bouten et al...
December 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29222797/an-in-vivo-compression-model-of-spinal-cord-injury
#8
Irene Paterniti, Emanuela Esposito, Salvatore Cuzzocrea
Animal spinal cord injury (SCI) models have proven highly useful for investigating the mechanisms involved in the injury process and evaluating the effectiveness of experimental therapeutic interventions. Over the last years, substantial improvements have been made in producing consistent and reproducible animal SCI models. Different SCI models have been developed to address the mechanism of injury, being divided into contusion, compression, distraction, dislocation, transection, or chemical models. The method described here is a mouse compression model of SCI that, in many respects, faithfully reproduces SCI in man...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222006/wrist-accelerometry-for-physical-activity-measurement-in-individuals-with-spinal-cord-injury-a-need-for-individually-calibrated-cut-points
#9
Laura A McCracken, Jasmin K Ma, Christine Voss, Franco H N Chan, Kathleen A Martin Ginis, Christopher R West
OBJECTIVE: To create and compare individual and group-based cut-points for wrist-accelerometry that corresponds to moderate-to-vigorous physical activity (MVPA) in people with spinal cord injury (SCI). DESIGN: Participants completed a graded treadmill-wheeling test while being assessed for oxygen consumption, wrist-acceleration vector magnitude, and spoke acceleration. Oxygen consumption was converted to SCI metabolic equivalents (SCI METS) and linear regression was applied to determine an individualized vector magnitude cut-point (counts per minute, VM-CPM) corresponding with MVPA (≥3 SCI METS)...
December 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29221205/thrombospondin-1-modified-bone-marrow-mesenchymal-stem-cells-bmscs-promote-neurite-outgrowth-and-functional-recovery-in-rats-with-spinal-cord-injury
#10
Yujie Pu, Ke Meng, Chuanlong Gu, Linlin Wang, Xiaoming Zhang
Stem cell therapies are currently gaining momentum in the treatment of spinal cord injury (SCI). However, unsatisfied intrinsic neurite growth capacity constitutes significant obstacles for injured spinal cord repair and ultimately results in neurological dysfunction. The present study assessed the efficacy of thrombospondin-1 (TSP-1), a neurite outgrowth-promoting molecule, modified bone marrow mesenchymal stem cells (BMSCs) on promoting neurite outgrowth in vitro and in vivo of Oxygen-Glucose Deprivation (OGD) treated motor neurons and SCI rat models...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218499/effect-of-clip3-upregulation-on-astrocyte-proliferation-and-subsequent-glial-scar-formation-in-the-rat-spinal-cord-via-stat3-pathway-after-injury
#11
Xiaoqing Chen, Cheng Chen, Jie Hao, Jiyun Zhang, Feng Zhang
Spinal cord injury (SCI) is a devastating event resulting in neuron degeneration and permanent paralysis through inflammatory cytokine overproduction and glial scar formation. Presently, the endogenous molecular mechanisms coordinating glial scar formation in the injured spinal cord remain elusive. Signal transducer and activator of transcription 3 (STAT3) is a well-known transcription factor particularly involving in cell proliferation and inflammation in the lesion site following SCI. Meanwhile, CAP-Gly domain containing linker protein 3(CLIP3), a vital cytoplasmic protein, has been confirmed to providing an optimal conduit for intracellular signal transduction and interacting with STAT3 with mass spectrometry analysis...
December 7, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29217422/hyperbaric-oxygen-ameliorated-the-lesion-scope-and-nerve-function-in-acute-spinal-cord-injury-patients-a-retrospective-study
#12
Jie-Wen Tan, Fang Zhang, He-Jun Liu, Zhuo Li
OBJECTIVE: This is a retrospective study to assess the therapeutic effect of hyperbaric oxygen (HBO) in early treatment of acute spinal cord injury (SCI) using magnetic resonance imaging (MRI) and electrophysiology in diagnosing. METHODS: Forty acute SCI patients from Sun Yat-Sen Memorial Hospital who were assigned into HBO treatment were included during August 2013 to October 2014.The patients with adverse reactions or contraindications for HBO were assigned as controls...
December 4, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29215736/protective-effect-of-epigenetic-silencing-of-cyclind1-against-spinal-cord-injury-using-bone-marrow-derived-mesenchymal-stem-cells-in-rats
#13
Yuan Wang, Qing-Jie Kong, Jin-Chuan Sun, Xi-Ming Xu, Yong Yang, Ning Liu, Jian-Gang Shi
OBJECTIVE: This study focuses on the protective effect of epigenetic silencing of CyclinD1 against spinal cord injury (SCI) using bone marrow-derived mesenchymal stem cells (BMSCs) in rats. METHODS: Eighty-eight adult female Wistar rats were randomly assigned into the sham group, the control group, the si-CyclinD1 + BMSCs group and the BMSCs group. CyclinD1 protein and mRNA expressions after siRNA transfection were detected by western blotting and qRT-PCR. The siRNA-CyclinD1 BMSCs were transplanted into rats in the si-CyclinD1 + BMSCs group using stereotaxic method 6 h after SCI...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29211040/promoting-long-term-health-among-people-with-spinal-cord-injury-what-s-new
#14
Mary Ann McColl, Shikha Gupta, Karen Smith, Alexander McColl
A key ingredient to successful health promotion is a primary care provider who can offer an informed first response to lifestyle issues, emerging problems and chronic challenges. This article aims to assist family physicians to play their role in promoting the health of people with SCI, by summarizing the latest evidence in the management of spinal cord injury in primary care. This study used a scoping review methodology to survey peer-reviewed journal articles and clinical guidelines published between January 2012 to June 2016...
December 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29209172/the-role-of-netrin-1-in-improving-functional-recovery-through-autophagy-stimulation-following-spinal-cord-injury-in-rats
#15
Liangjie Bai, Xifan Mei, Yanfeng Wang, Yajiang Yuan, Yunlong Bi, Gang Li, Hongyu Wang, Peng Yan, Gang Lv
Our previous findings indicated that treatment with Netrin-1 could improve functional recovery through the stimulation of autophagy, by activating the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) signaling pathway in rats following spinal cord injury (SCI). However, the underlying mechanisms were not elucidated. The purpose of this study was to investigate the underlying mechanisms by which Netrin-1 promotes autophagy and improves functional recovery after SCI. Following controlled SCI in Sprague-Dawley rats, we observed that the autophagic flux in neurons was impaired, as reflected by the accumulation of light chain 3-II (LC3-II)-positive and LC3-positive autophagosomes (APs), accompanied by the accumulation of the autophagic substrate, Sequestosome 1 (SQSTM1; also known as p62)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29209163/voluntary-ambulation-by-upper-limb-triggered-hal%C3%A2-in-patients-with-complete-quadri-paraplegia-due-to-chronic-spinal-cord-injury
#16
Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Kenji Suzuki, Tetsuya Abe, Tomoyuki Ueno, Yuichiro Soma, Yoshiyuki Sankai, Yasushi Hada, Masashi Yamazaki
Patients with complete paraplegia after spinal cord injury (SCI) are unable to stand or walk on their own. Standing exercise decreases the risk of decubitus ulcers, osteoporosis, and joint deformities in patients with SCI. Conventional gait training for complete paraplegia requires excessive upper limb usage for weight bearing and is difficult in cases of complete quadriplegia. The purpose of this study was to describe voluntary ambulation triggered by upper limb activity using the Hybrid Assistive Limb® (HAL) in patients with complete quadri/paraplegia after chronic SCI...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29208284/corrigendum-to-liposome-based-drug-co-delivery-systems-in-cancer-cells-mater-sci-eng-c-71-2017-1327-1341
#17
Sepideh Zununi Vahed, Roya Salehi, Soodabeh Davaran, Simin Sharifi
No abstract text is available yet for this article.
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29207118/oxysophoridine-rescues-spinal-cord-injury-via-anti%C3%A2-inflammatory-anti%C3%A2-oxidative-stress-and-anti%C3%A2-apoptosis-effects
#18
Zhong Cao, Liang Chen, Yanbin Liu, Tao Peng
Oxysophoridine (OSR) is an alkaloid extracted from Sophora alopecuroides L and has various pharmacological activities. The present study aimed to investigate the protective effects and underlying mechanisms of OSR on spinal cord injury (SCI), a clinically common serious trauma, in a rat model. The results of the present study demonstrated that the anti‑inflammatory effect of OSR improved Basso, Beatie and Bresnahan Locomotor Rating Scale scores and reduced spinal cord tissue water contents in an SCI rat model...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205982/spasticity-or-periodic-limb-movements
#19
Jonathan Levy, Sarah Hartley, Elsa Mauruc-Soubirac, Antoine Leotard, Frederic Lofaso, Maria-Antonia Quera-Salva, Djamel Bensmail
BACKGROUND: Spasticity and spasms are distressing features of the upper motor neuron syndrome (UMNS) following spinal cord injuries (SCI) or multiple sclerosis (MS), and have common therapeutic implications. Despite an increase of antispastic drugs and strategies, sometimes up to the surgical implant of intrathecal baclofen pump, some patients still complain of disabling spasms, which poses diagnostic and therapeutic challenges. Although clinically similar, flexor spasms due to pyramidal tract disruption must be clearly differentiated from periodic limb movements (PLM), often accompanying restless leg syndrome (RLS) and occurring during sleep...
December 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29205960/what-do-medical-students-learn-from-dissection
#20
Natasha A M S Flack, Helen D Nicholson
Dissection has long been the accepted method for teaching anatomy to medical students. More recently, some educators have suggested that easier, cheaper, alternative methods are just as effective. But what do the students think? This paper aimed to identify what undergraduate medical students learn, how they cope, and what effects participating in dissection has on them as individuals. A cohort of 267 second year medical students at Otago Medical School were invited to complete three online surveys; before their first dissection laboratory class, after their first musculoskeletal system dissection and following the last semester of studying anatomy...
December 4, 2017: Anatomical Sciences Education
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