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https://www.readbyqxmd.com/read/28231408/climbing-bloom-s-taxonomy-pyramid-lessons-from-a-graduate-histology-course
#1
Nikki B Zaidi, Charles Hwang, Sara Scott, Stefanie Stallard, Joel Purkiss, Michael Hortsch
Bloom's taxonomy was adopted to create a subject-specific scoring tool for histology multiple-choice questions (MCQs). This Bloom's Taxonomy Histology Tool (BTHT) was used to analyze teacher- and student-generated quiz and examination questions from a graduate level histology course. Multiple-choice questions using histological images were generally assigned a higher BTHT level than simple text questions. The type of microscopy technique (light or electron microscopy) used for these image-based questions did not result in any significant differences in their Bloom's taxonomy scores...
February 23, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28231405/three-dimensional-printing-of-x-ray-computed-tomography-datasets-with-multiple-materials-using-open-source-data-processing
#2
Ian M Sander, Matthew T McGoldrick, My N Helms, Aislinn Betts, Anthony van Avermaete, Elizabeth Owers, Evan Doney, Taimi Liepert, Glen Niebur, Douglas Liepert, W Matthew Leevy
Advances in three-dimensional (3D) printing allow for digital files to be turned into a "printed" physical product. For example, complex anatomical models derived from clinical or pre-clinical X-ray computed tomography (CT) data of patients or research specimens can be constructed using various printable materials. Although 3D printing has the potential to advance learning, many academic programs have been slow to adopt its use in the classroom despite increased availability of the equipment and digital databases already established for educational use...
February 23, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28230791/the-temporal-pattern-flux-and-function-of-autophagy-in-spinal-cord-injury
#3
REVIEW
Kailiang Zhou, Charles A Sansur, Huazi Xu, Xiaofeng Jia
Previous studies have indicated that autophagy plays a critical role in spinal cord injury (SCI), including traumatic spinal cord injury (TSCI) and ischemia-reperfusion spinal cord injury (IRSCI). However, while the understanding of mechanisms underlying autophagy in SCI has progressed, there remain several controversial points: (1) temporal pattern results of autophagic activation after SCI are not consistent across studies; (2) effect of accumulation of autophagosomes due to the blockade or enhancement of autophagic flux is uncertain; (3) overall effect of enhanced autophagy remains undefined, with both beneficial and detrimental outcomes reported in SCI literature...
February 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28230415/targeting-translational-successes-through-cansort-sci-using-pet-dogs-to-identify-effective-treatments-for-spinal-cord-injury
#4
Sarah A Moore, Nicolas Granger, Natasha Olby, Ingo Spitzbarth, Nick D Jeffery, Andrea Tipold, Yvette S Nout-Lomas, Ronaldo da Costa, Veronika Stein, Linda Noble-Haeusslein, Andrew R Blight, Robert Grossman, D Michele Basso, Jonathan Michael Levine
Translation of therapeutic interventions for spinal cord injury (SCI) from laboratory to clinic has been historically challenging, highlighting the need for robust models of injury that more closely mirror the human condition. The high prevalence of acute, naturally occurring SCI in pet dogs provides a unique opportunity to expeditiously evaluate promising interventions in a population of animals that are diagnosed and managed clinically in a manner similar to spinal cord-injured people, while adhering to NIH guidelines for scientific rigor and transparent reporting...
February 23, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28229644/emg-activity-of-upper-limb-on-spinal-cord-injury-individuals-during-whole-body-vibration
#5
Uslg Da Silva, H A Villagra, L L Oliva, N F Marconi
Whole-body vibration (WBV) has shown positive results increasing electromyographic (EMG) activity and strength in a healthy population when applied to upper and lower limbs. The aim of this study was to verify if WBV increases the EMG signal of the upper limb muscles in patients with spinal cord injury (SCI). For this study, 15 patients with SCI were selected and one single session of WBV was applied to the upper limb. Five sessions of 30 s at 30 Hz were applied and EMG of anterior deltoid and forearm muscles was measured...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28228721/patients-with-chronic-spinal-cord-injury-exhibit-reduced-autonomic-modulation-during-an-emotion-recognition-task
#6
Gonzalo Varas-Díaz, Enzo P Brunetti, Gonzalo Rivera-Lillo, Pedro E Maldonado
Spinal cord injury (SCI) is a devastating event for individuals, who frequently develop motor and sensory impairment as well as autonomic dysfunction. Previous studies reported that autonomic activity plays a major role in social cognition and that difficulties in the ability to interpret social information are commonly observed in a variety of mental disorders, which in turn correlate with a poor autonomic nervous system (ANS) regulation. It is well established that subjects with SCI have an alteration in ANS regulation mechanisms...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28228335/alterations-in-cardiac-autonomic-control-in-spinal-cord-injury
#7
Fin Biering-Sørensen, Tor Biering-Sørensen, Nan Liu, Lasse Malmqvist, Jill Maria Wecht, Andrei Krassioukov
A spinal cord injury (SCI) interferes with the autonomic nervous system (ANS). The effect on the cardiovascular system will depend on the extent of damage to the spinal/central component of ANS. The cardiac changes are caused by loss of supraspinal sympathetic control and relatively increased parasympathetic cardiac control. Decreases in sympathetic activity result in heart rate and the arterial blood pressure changes, and may cause arrhythmias, in particular bradycardia, with the risk of cardiac arrest in those with cervical or high thoracic injuries...
February 15, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28228044/withaferin-a-protects-against-spinal-cord-injury-by-inhibiting-apoptosis-and-inflammation-in-mice
#8
Xianlei Yan, Guangxiang Huang, Quan Liu, Jiemin Zheng, Hongmou Chen, Qidan Huang, Jiakang Chen, Heqing Huang
CONTEXT: Withaferin A (WFA) exhibits diverse pharmaceutical applications on human diseases, including rheumatoid arthritis, cancers and microbial infection. OBJECTIVE: We evaluated the neuroprotective role of WFA using a mouse model of spinal cord injury (SCI). MATERIALS AND METHODS: BALB/c mice were administrated 10 mg/kg of WFA. Gene expression was measured by real-time PCR, western blot and immunohistochemistry. Cell morphology and apoptosis were determined by H&E staining and TUNEL assay...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28227969/effects-of-lower-limb-electrical-stimulation-on-trunk-stability-in-persons-with-sci-during-walking-a-case-series
#9
Kamyar Momeni, Stephen Canton, Arvind Ramanujam, Erica Garbarini, Gail F Forrest, Kamyar Momeni, Stephen Canton, Arvind Ramanujam, Erica Garbarini, Gail F Forrest, Arvind Ramanujam, Gail F Forrest, Kamyar Momeni, Stephen Canton, Erica Garbarini
The purpose of the present case series was to investigate whether three lower limb rehabilitation training approaches have any effects on trunk stability of persons with motor complete SCI during a 10-minute assisted walk. These trainings included electrical stimulation (ES), standing retraining (SRT), and a novel multi-modality approach that combined ES with SRT. We observed that multi-muscle ES directed at the lower limbs had a prominent, indirect effect on the upper and lower muscles of the trunk. More specifically, trunk muscle activations of the ES+SRT subject increased after training for the more distal muscles of the trunk...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#10
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227641/optimization-of-an-unpowered-energy-stored-exoskeleton-for-patients-with-spinal-cord-injury
#11
Xinyu Guan, Linhong Ji, Rencheng Wang, Wenjie Huang, Xinyu Guan, Linhong Ji, Rencheng Wang, Wenjie Huang, Rencheng Wang, Xinyu Guan, Wenjie Huang, Linhong Ji
The paper describes a novel unpowered energy-stored exoskeleton (ES-EXO) for spinal cord injured patients in consideration of patients' characteristics and injured levels. It proposed a method to optimize the energy-stored element to decrease the hip joint moment in walking. EMG patterns, ground reaction force and motion data from one participant with complete spinal cord injury at T10 were recorded. A combined human-ES-EXO model was built and the stored-energy element including locations and stiffness of springs were optimized in AnyBody Modeling System...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227332/using-surface-electromyography-to-detect-changes-in-innervation-zones-pattern-after-human-cervical-spinal-cord-injury
#12
Babak Afsharipour, Milap S Sandhu, Ghulam Rasool, Nina L Suresh, William Z Rymer, Babak Afsharipour, Milap S Sandhu, Ghulam Rasool, Nina L Suresh, William Z Rymer, Milap S Sandhu, Babak Afsharipour, William Z Rymer, Nina L Suresh, Ghulam Rasool
Human spinal cord injuries (SCI) disrupt the pathways between brain and spinal cord, resulting in substantial impairment and loss of function. Currently, we do not have the ability to precisely quantify the "functional" level of motor injury. The aim of this study is to determine if high-density surface electromyography imaging (SEI) can be used to characterize the location and extent of the spinal lesion. SEI is a safe and non-invasive technique, which uses several electrodes to provide a map of muscle activity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227218/effect-of-wearable-sensor-dynamics-on-physical-activity-estimates-a-comparison-between-sci-vs-healthy-individuals
#13
C Jayaraman, C K Mummidisetty, A Jayaraman, C Jayaraman, C K Mummidisetty, A Jayaraman, C K Mummidisetty, A Jayaraman, C Jayaraman
Accuracy of physical activity estimates predicted by activity monitoring technologies may be affected by device location, analysis algorithms, type of technology (i.e. wearable/stickable) and population demographics (disability) being studied. Consequently, the main purpose of this investigation was to study such sensor dynamics (i.e. effect of device location, type and population demographics on energy expenditure estimates) of two commercial activity monitors. It was hypothesized that device location, population studied (disability), choice of proprietary algorithm and type of technology used will significantly impact the accuracy of the predicted physical activity metrics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227184/neuromotor-response-of-the-leg-muscles-following-a-supine-stand-retraining-with-without-neuromuscular-electrical-stimulation-training-intervention-for-individuals-with-sci-a-case-series
#14
Stephen Canton, Kamyar Momeni, Arvind Ramanujam, Erica Garbarini, Gail F Forrest, Stephen Canton, Kamyar Momeni, Arvind Ramanujam, Erica Garbarini, Gail F Forrest, Arvind Ramanujam, Gail F Forrest, Stephen Canton, Kamyar Momeni, Erica Garbarini
The goal of this paper is to study the effects of supine and stand retraining (SRT) interventions with and without multi muscle neuromuscular electrical stimulation (NMES) on the neuromuscular EMG responses of the leg muscles for individuals with motor complete SCI during walking on a body-weight support (BWS) treadmill. The main outcome variables were EMG amplitude, integrated EMG and co-contraction indices (co-excitation and co-activation) collected during a 10-minute walking treadmill trial. Data was analyzed for the first, fifth and tenth minute of walking...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226845/validation-of-empirical-mode-decomposition-combined-with-notch-filtering-to-extract-electrical-stimulation-artifact-from-surface-electromyograms-during-functional-electrical-stimulation
#15
Rakesh Pilkar, Arvind Ramanujam, Erica Garbarini, Gail Forrest, Rakesh Pilkar, Arvind Ramanujam, Erica Garbarini, Gail Forrest, Rakesh Pilkar, Erica Garbarini, Arvind Ramanujam, Gail Forrest
This paper presents the validity of Empirical Mode Decomposition (EMD) combined with Notch filtering to remove the electrical stimulation (ES) artifact from surface electromyogram (EMG) data for interpretation of muscle responses during Functional Electrical Stimulation (FES) experiments. We hypothesized that the EMD algorithm provides a suitable platform for decomposing the EMG signal into physically meaningful intrinsic mode functions (IMFs) which can be further used to isolate electrical stimulation (ES) artifact...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226803/closed-loop-afferent-electrical-stimulation-for-recovery-of-hand-function-in-individuals-with-motor-incomplete-spinal-injury-early-clinical-results
#16
Christopher J Schildt, Sarah H Thomas, Elizabeth S Powell, Lumy Sawaki, Sridhar Sunderam, Christopher J Schildt, Sarah H Thomas, Elizabeth S Powell, Lumy Sawaki, Sridhar Sunderam, Lumy Sawaki, Christopher J Schildt, Elizabeth S Powell, Sarah H Thomas, Sridhar Sunderam
Afferent electrical stimulation is known to augment the effect of rehabilitative therapy through use-dependent cortical plasticity. Experiments pairing transcranial magnetic stimulation (TMS) with peripheral nerve stimulation (PNS) have shown a timing-dependent effect on motor evoked potential (MEP) amplitude suggesting that PNS applied in closed-loop (CL) mode could augment this effect through positive reinforcement. We present early results from a clinical trial in which an EEG brain-machine interface (BMI) was used to apply PNS to two subjects in response to motor intent detected from sensorimotor cortex in a cue-driven hand grip task...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226566/quantifying-the-human-robot-interaction-forces-between-a-lower-limb-exoskeleton-and-healthy-users
#17
Ashish Rathore, Matthew Wilcox, Dafne Zuleima Morgado Ramirez, Rui Loureiro, Tom Carlson, Ashish Rathore, Matthew Wilcox, Dafne Zuleima Morgado Ramirez, Rui Loureiro, Tom Carlson, Rui Loureiro, Matthew Wilcox, Ashish Rathore, Tom Carlson, Dafne Zuleima Morgado Ramirez
To counter the many disadvantages of prolonged wheelchair use, patients with spinal cord injuries (SCI) are beginning to turn towards robotic exoskeletons. However, we are currently unaware of the magnitude and distribution of forces acting between the user and the exoskeleton. This is a critical issue, as SCI patients have an increased susceptibility to skin lesions and pressure ulcer development. Therefore, we developed a real-time force measuring apparatus, which was placed at the physical human-robot interface (pHRI) of a lower limb robotic exoskeleton...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225648/safety-of-autologous-human-schwann-cell-transplantation-in-subacute-thoracic-spinal-cord-injury
#18
Kimberly D Anderson, James Guest, W Dalton Dietrich, Mary B Bunge, Rosie Curiel, Marine Dididze, Barth A Green, Aisha Khan, Damien D Pearse, Efrat Saraf-Lavi, Eva Widerstrom-Noga, Pat Wood, Allan D Levi
The rationale for implantation of autologous human Schwann cells (SCs) in people with subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are neuroprotective, support local axonal plasticity, and are capable of myelinating axons. A Phase I clinical trial was conducted to evaluate the safety of autologous human SC transplantation into the injury epicenter of six subjects with subacute SCI. The trial was an open-label, unblinded, non-randomized, non-placebo controlled study with a dose escalation design and standard medical rehabilitation...
February 18, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28225536/reliability-and-cross-cultural-adaptation-of-the-turkish-version-of-the-spinal-cord-injury-spasticity-evaluation-tool
#19
Pinar Akpinar, Arzu Atici, Kubra N Kurt, Feyza U Ozkan, Ilknur Aktas, Duygu G Kulcu
The Spinal Cord Injury Spasticity Evaluation Tool is a 7-day recall self-reported questionnaire that assesses the problematic and useful effects of spasticity on daily life in patients with spinal cord injury (SCI). We aimed to determine the reliability and cross-cultural validation of the Turkish translation of the Spinal Cord Injury Spasticity Evaluation Tool (SCI-SETT). After translation and back translation of the Spinal Cord Injury Spasticity Evaluation Tool, 66 patients between the ages of 18 and 88 years with SCI, American Spinal Injury Association impairment scale grades from A to D with spasticity, and at least 6 months after injury were assessed...
February 20, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28225323/sci-facts-and-figures
#20
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No abstract text is available yet for this article.
January 2017: Journal of Spinal Cord Medicine
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