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https://www.readbyqxmd.com/read/27914058/osprey-predicts-resistance-mutations-using-positive-and-negative-computational-protein-design
#1
Adegoke Ojewole, Anna Lowegard, Pablo Gainza, Stephanie M Reeve, Ivelin Georgiev, Amy C Anderson, Bruce R Donald
Drug resistance in protein targets is an increasingly common phenomenon that reduces the efficacy of both existing and new antibiotics. However, knowledge of future resistance mutations during pre-clinical phases of drug development would enable the design of novel antibiotics that are robust against not only known resistant mutants, but also against those that have not yet been clinically observed. Computational structure-based protein design (CSPD) is a transformative field that enables the prediction of protein sequences with desired biochemical properties such as binding affinity and specificity to a target...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27912248/mean-arterial-blood-pressure-management-of-acute-spinal-cord-injured-patients-during-the-pre-hospital-and-early-admission-period
#2
Jin Wee Tee, Farhaan Altaf, Lise M Belanger, Tamir Ailon, John Street, Scott J Paquette, Michael C Boyd, Charles G Fisher, Marcel F Dvorak, Brian K Kwon
The optimization and maintenance of mean arterial blood pressure (MAP) and the general avoidance of systemic hypotension for the first 5 to 7 days following acute traumatic SCI is considered to be important for minimizing secondary spinal cord ischemic damage. The characterization of hemodynamic parameters in the immediate post-injury stage prior to admission to a specialized spine unit has not been previously reported. Here we describe the blood pressure management of 40 acute tSCI patients in the early post-injury phases of care prior to their arrival in a specialized spinal injury high dependency unit (HDU), intensive care unit (ICU) or operating room (OR)...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27912032/pain-input-impairs-recovery-after-spinal-cord-injury-treatment-with-lidocaine
#3
Joel D Turtle, Misty M Strain, Miriam Aceves, Yung-Jen Huang, Joshua A Reynolds, Michelle A Hook, James W Grau
More than 90% of spinal cord injuries are caused by traumatic accidents and are often associated with other tissue damage (polytrauma) that can provide a source of continued pain input during recovery. In a clinically relevant spinal cord contusion injury model, prior work has shown that noxious stimulation at an intensity that engages pain (C) fibers soon after injury augments secondary injury and impairs functional recovery. Noxious input increases the expression of pro-inflammatory cytokines (interleukin 1β and 18), cellular signals associated with cell death (caspase 3 and 8), and physiological signs of hemorrhage...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27911990/academic-nightmares-predatory-publishing
#4
Sonya E Van Nuland, Kem A Rogers
Academic researchers who seek to publish their work are confronted daily with a barrage of e-mails from aggressive marketing campaigns that solicit them to publish their research with a specialized, often newly launched, journal. Known as predatory journals, they often promise high editorial and publishing standards, yet their exploitive business models, poor quality control, and minimal overall transparency victimize those researchers with limited academic experience and pave the way for low-quality articles that threaten the foundation of evidence-based research...
December 2, 2016: Anatomical Sciences Education
https://www.readbyqxmd.com/read/27911710/eml-proteins-in-microtubule-regulation-and-human-disease
#5
REVIEW
Andrew M Fry, Laura O'Regan, Jessica Montgomery, Rozita Adib, Richard Bayliss
The EMLs are a conserved family of microtubule-associated proteins (MAPs). The founding member was discovered in sea urchins as a 77-kDa polypeptide that co-purified with microtubules. This protein, termed EMAP for echinoderm MAP, was the major non-tubulin component present in purified microtubule preparations made from unfertilized sea urchin eggs [J. Cell Sci. (1993) 104: , 445-450; J. Cell Sci. (1987) 87: (Pt 1), 71-84]. Orthologues of EMAP were subsequently identified in other echinoderms, such as starfish and sand dollar, and then in more distant eukaryotes, including flies, worms and vertebrates, where the name of ELP or EML (both for EMAP-like protein) has been adopted [BMC Dev...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27910683/publisher-s-note-in-vessel-calibration-of-the-imaging-diagnostics-for-the-real-time-protection-of-the-jet-iter-like-wall-rev-sci-instrum-87-11d430-2016
#6
V Huber, A Huber, D Kinna, I Balboa, S Collins, N Conway, P Drewelow, C F Maggi, G F Matthews, A G Meigs, Ph Mertens, M Price, G Sergienko, S Silburn, A Wynn, K-D Zastrow
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910682/publisher-s-note-electron-density-profile-measurements-from-hydrogen-line-intensity-ratio-method-in-versatile-experiment-spherical-torus-rev-sci-instrum-87-11e540-2016
#7
YooSung Kim, Yue-Jiang Shi, Jeong-Hun Yang, SeongCheol Kim, Young-Gi Kim, Jeong-Jeung Dang, Seongmoo Yang, Jungmin Jo, Soo-Ghee Oh, Kyoung-Jae Chung, Y S Hwang
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910680/publisher-s-note-multi-energy-x-ray-detector-calibration-for-t-and-impurity-density-n-measurements-of-mcf-plasmas-rev-sci-instrum-87-11e320-2016
#8
J Maddox, N Pablant, P Efthimion, L Delgado-Aparicio, K W Hill, M Bitter, M L Reinke, M Rissi, T Donath, B Luethi, B Stratton
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910675/erratum-a-fast-real-time-measurement-system-to-track-in-and-out-of-plane-optical-retardation-birefringence-true-stress-and-true-strain-during-biaxial-stretching-of-polymer-films-rev-sci-instrum-83-123901-2012
#9
https://www.readbyqxmd.com/read/27910662/a-novel-multi-channel-quadrature-doppler-backward-scattering-reflectometer-on-the-hl-2a-tokamak
#10
Zhongbing Shi, Wulu Zhong, Min Jiang, Zengchen Yang, Boyu Zhang, Peiwan Shi, Wei Chen, Jie Wen, Chengyuan Chen, Bingzhong Fu, Zetian Liu, Xuantong Ding, Qingwei Yang, Xuru Duan
A novel 16-channel fixed frequency Doppler backward scattering (DBS) reflectometer system has been developed on the HL-2A tokamak. This system is based on the filter-based feedback loop microwave source (FFLMS) technique, which has lower phase noise and lower power variation compared with present tunable frequency generation and comb frequency array generation techniques [J. C. Hillesheim et al. Rev. Sci. Instrum. 80, 083507 (2009) and W. A. Peebles et al. Rev. Sci. Instrum. 81, 10D902 (2010)]. The 16-channel DBS system is comprised of four × four-frequency microwave transmitters and direct quadrature demodulation receivers...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910645/publisher-s-note-gaseous-electron-multiplier-based-soft-x-ray-plasma-diagnostics-development-preliminary-tests-at-asdex-upgrade-rev-sci-instrum-87-11e325-2016
#11
M Chernyshova, K Malinowski, T Czarski, A Wojeński, D Vezinet, K T Poźniak, G Kasprowicz, D Mazon, A Jardin, A Herrmann, E Kowalska-Strzęciwilk, R Krawczyk, P Kolasiński, W Zabołotny, P Zienkiewicz
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910564/high-resolution-x-ray-thomson-scattering-measurements-from-cryogenic-hydrogen-jets-using-the-linac-coherent-light-source
#12
L B Fletcher, U Zastrau, E Galtier, E J Gamboa, S Goede, W Schumaker, A Ravasio, M Gauthier, M J MacDonald, Z Chen, E Granados, H J Lee, A Fry, J B Kim, C Roedel, R Mishra, A Pelka, D Kraus, B Barbrel, T Döppner, S H Glenzer
We present the first spectrally resolved measurements of x-rays scattered from cryogenic hydrogen jets in the single photon counting limit. The 120 Hz capabilities of the LCLS, together with a novel hydrogen jet design [J. B. Kim et al., Rev. Sci. Instrum. (these proceedings)], allow for the ability to record a near background free spectrum. Such high-dynamic-range x-ray scattering measurements enable a platform to study ultra-fast, laser-driven, heating dynamics of hydrogen plasmas. This measurement has been achieved using two highly annealed pyrolytic graphite crystal spectrometers to spectrally resolve 5...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910530/spectral-measurements-of-asymmetrically-irradiated-capsule-backlighters
#13
P A Keiter, R P Drake
Capsule backlighters provide a quasi-continuum x-ray spectrum over a wide range of photon energies [J. F. Hansen et al., Rev. Sci. Instrum. 79, 013504 (2008)]. Ideally one irradiates the capsule backlighter symmetrically, however, in complex experimental geometries, this is not always possible. In recent experiments we irradiated capsule backlighters asymmetrically and measured the x-ray spectrum from multiple directions. We will present time-integrated spectra over the photon energy range of 2-13 keV and time-resolved spectra over the photon energy range of 2-3 keV...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910520/publisher-s-note-structured-photocathodes-for-improved-high-energy-x-ray-efficiency-in-streak-cameras-rev-sci-instrum-87-11e331-2016
#14
Y P Opachich, P M Bell, D K Bradley, N Chen, J Feng, A Gopal, B Hatch, T J Hilsabeck, E Huffman, J A Koch, O L Landen, A G MacPhee, S R Nagel, S Udin
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910458/publisher-s-note-talbot-lau-x-ray-deflectometer-electron-density-diagnostic-for-laser-and-pulsed-power-high-energy-density-plasma-experiments-invited-rev-sci-instrum-87-11d501-2016
#15
M P Valdivia, D Stutman, C Stoeckl, C Mileham, I A Begishev, W Theobald, J Bromage, S P Regan, S R Klein, G Muñoz-Cordovez, M Vescovi, V Valenzuela-Villaseca, F Veloso
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910406/comparison-of-implosion-core-metrics-a-10-ps-dilation-x-ray-imager-vs-a-100-ps-gated-microchannel-plate
#16
S R Nagel, L R Benedetti, D K Bradley, T J Hilsabeck, N Izumi, S Khan, G A Kyrala, T Ma, A Pak
The dilation x-ray imager (DIXI) [T. J. Hilsabeck et al., Rev. Sci. Instrum. 81, 10E317 (2010); S. R. Nagel et al., ibid. 83, 10E116 (2012); S. R. Nagel et al., ibid. 85, 11E504 (2014)] is a high-speed x-ray framing camera that uses the pulse-dilation technique to achieve a temporal resolution of less than 10 ps. This is a 10 × improvement over conventional framing cameras currently employed on the National Ignition Facility (NIF) (100 ps resolution), and otherwise only achievable with 1D streaked imaging...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910397/enhanced-magnetic-field-probe-array-for-improved-excluded-flux-calculations-on-the-c-2u-advanced-beam-driven-field-reversed-configuration-plasma-experiment
#17
T Roche, M C Thompson, R Mendoza, I Allfrey, E Garate, J Romero, J Douglass
External flux conserving coils were installed onto the exterior of the C-2U [M. W. Binderbauer et al., Phys. Plasmas 22, 056110 (2015)] confinement vessel to increase the flux confinement time of the system. The 0.5 in. stainless steel vessel wall has a skin time of ∼5 ms. The addition of the external copper coils effectively increases this time to ∼7 ms. This led to better-confined/longer-lived field-reversed configuration (FRC) plasmas. The fringing fields generated by the external coils have the side effect of rendering external field measurements invalid...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910364/spectroscopic-imaging-of-limiter-heat-and-particle-fluxes-and-the-resulting-impurity-sources-during-wendelstein-7-x-startup-plasmas
#18
L Stephey, G A Wurden, O Schmitz, H Frerichs, F Effenberg, C Biedermann, J Harris, R König, P Kornejew, M Krychowiak, E A Unterberg
A combined IR and visible camera system [G. A. Wurden et al., "A high resolution IR/visible imaging system for the W7-X limiter," Rev. Sci. Instrum. (these proceedings)] and a filterscope system [R. J. Colchin et al., Rev. Sci. Instrum. 74, 2068 (2003)] were implemented together to obtain spectroscopic data of limiter and first wall recycling and impurity sources during Wendelstein 7-X startup plasmas. Both systems together provided excellent temporal and spatial spectroscopic resolution of limiter 3. Narrowband interference filters in front of the camera yielded C-III and Hα photon flux, and the filterscope system provided Hα, Hβ, He-I, He-II, C-II, and visible bremsstrahlung data...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910360/publisher-s-note-polarimeter-for-the-general-fusion-spector-machine-rev-sci-instrum-87-11e104-2016
#19
Patrick Carle, Aaron Froese, Adrian Wong, Stephen Howard, Peter O'Shea, Michel Laberge
No abstract text is available yet for this article.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910335/detailed-characterization-of-the-llnl-imaging-proton-spectrometer
#20
A M Rasmus, A U Hazi, M J-E Manuel, C C Kuranz, S R Klein, P X Belancourt, J R Fein, M J MacDonald, R P Drake, B B Pollock, J Park, G J Williams, H Chen
Ultra-intense short pulse lasers incident on solid targets (e.g., thin Au foils) produce well collimated, broad-spectrum proton beams. These proton beams can be used to characterize magnetic fields, electric fields, and density gradients in high energy-density systems. The LLNL-Imaging Proton Spectrometer (L-IPS) was designed and built [H. Chen et al., Rev. Sci. Instrum. 81, 10D314 (2010)] for use with such laser produced proton beams. The L-IPS has an energy range of 50 keV-40 MeV with a resolving power (E/dE) of about 275 at 1 MeV and 21 at 20 MeV, as well as a single spatial imaging axis...
November 2016: Review of Scientific Instruments
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