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https://www.readbyqxmd.com/read/28320149/corrigendum-to-clinical-and-genetic-studies-in-patients-with-lafora-disease-from-pakistan-j-neurol-sci-373-2017-263-267
#1
Arsalan Ahmad, Rubina Dad, Muhammad Ikram Ullah, Tahir Ahmed Baig, Imran N Ahmad, Abdul Nasir, Christian A Hübner, Muhammad Jawad Hassan
No abstract text is available yet for this article.
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320111/corrigendum-to-the-utility-of-diffusion-mri-with-quantitative-adc-measurements-for-differentiating-high-grade-from-low-grade-cerebral-gliomas-evidence-from-a-meta-analysis-j-neurol-sci-373-2017-9-15
#2
Li Zhang, Zhiqian Min, Min Tang, Sipan Chen, Xiaoyan Lei, Xiaoling Zhang
No abstract text is available yet for this article.
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320049/d-%C3%AE-hydroxybutyrate-promotes-functional-recovery-and-relieves-pain-hypersensitivity-in-mice-with-spinal-cord-injury
#3
Jiao Qian, Wenjun Zhu, Ming Lu, Bin Ni, Jun Yang
BACKGROUND AND PURPOSE: Spinal cord injury (SCI) leads to severe motor and sensory dysfunction and significantly reduces the quality of life. The aim of present work was to investigate the effect of administration of exogenous D-β-hydroxybutyrate (DBHB) on functional recovery and neuropathic pain in spinal-cord-injured mice. EXPERIMENTAL APPROACH: Mice were given a moderate-severe thoracic spinal contusion injury at the T9-10 level, and treated with exogenous DBHB...
March 20, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28319944/time-of-day-could-affect-cognitive-screening-performance-in-older-patients-with-tia-and-stroke
#4
Sara Mazzucco, Linxin Li, Maria A Tuna, Sarah T Pendlebury, Rhoda Frost, Rose Wharton, Peter M Rothwell
BACKGROUND AND PURPOSE: The impact of time-of-day on the cognitive performance of older patients with limited cognitive reserve after a transient ischemic attack (TIA) or stroke, and on short cognitive tests, such as the Montreal Cognitive Assessment (MoCA), is unknown. We retrospectively studied whether morning versus afternoon assessment might affect the classification of patients aged 70 or older as severe (SCI), mild (MCI), and no (NCI) cognitive impairment by the MoCA. METHODS: Morning (12 p...
March 21, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28317599/corrigendum-to-the-effect-of-milk-allowance-on-behavior-and-weight-gains-in-dairy-calves-j-dairy-sci-100-504-512
#5
K Rosenberger, J H C Costa, H W Neave, D M Weary, M A G von Keyserlingk
No abstract text is available yet for this article.
April 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28317598/corrigendum-to-proteomics-method-to-quantify-the-percentage-of-cow-goat-and-sheep-milks-in-raw-materials-for-dairy-products-j-dairy-sci-99-9483-9492
#6
Q Chen, X Ke, J S Zhang, S Y Lai, F Fang, W M Mo, Y P Ren
No abstract text is available yet for this article.
April 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28315725/vibration-training-after-chronic-spinal-cord-injury-evidence-for-persistent-segmental-plasticity
#7
Chu-Ling Yen, Colleen L McHenry, Michael A Petrie, Shauna Dudley-Javoroski, Richard K Shields
H-reflex paired-pulse depression is gradually lost within the first year post-SCI, a process believed to reflect reorganization of segmental interneurons after the loss of normal descending (cortical) inhibition. This reorganization co-varies in time with the development of involuntary spasms and spasticity. The purpose of this study is to determine whether long-term vibration training may initiate the return of H-reflex paired-pulse depression in individuals with chronic, complete SCI. Five men with SCI received twice-weekly vibration training (30Hz, 0...
March 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28314966/-neuro-urological-diagnosis-and-therapy-of-lower-urinary-tract-dysfunction-in-patients-with-spinal-cord-injury-s2k-guideline-of-the-german-speaking-medical-society-of-paraplegia-dmgp-awmf-register-no-179-001
#8
R Böthig, B Domurath, A Kaufmann, J Bremer, W Vance, I Kurze
BACKGROUND: Most patients with spinal cord injury (SCI) suffer from neurogenic lower urinary tract dysfunction (NLUTD), bowel dysfunction and sexual dysfunction. If these remain untreated, severe medical complications and serious limitations (restrictions) in quality of life are imminent. OBJECTIVES: In the long term, there are considerable differences in the treatment results of highly specialized centers versus other treatment facilities. MATERIALS AND METHODS: Against this background, a consensus-based guideline, according to the AWMF (Association of the Scientific Medical Societies in Germany) criteria (S2k), was developed by the neuro-urology working group of the DMPG (German-Speaking Medical Society of Paraplegia)...
March 17, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28314429/erratum-to-heavy-metals-in-iberian-soils-removal-by-current-adsorbents-amendments-and-prospective-for-aerogels-adv-colloid-interf-sci-237-2016-28-42
#9
João P Vareda, Artur J M Valente, Luisa Durães
No abstract text is available yet for this article.
November 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28306359/spinal-cord-injuries-how-could-cell-therapy-help
#10
Anna Badner, Ahad M Siddiqui, Michael G Fehlings
Spinal cord injury (SCI) is a devastating condition, where regenerative failure and cell loss lead to paralysis. The heterogeneous and time-sensitive pathophysiology has made it difficult to target tissue repair. Despite many medical advances, there are no effective regenerative therapies. As stem cells offer multi-targeted and environmentally responsive benefits, cell therapy is a promising treatment approach. Areas covered: This review highlights the cell therapies being investigated for SCI, including Schwann cells, olfactory ensheathing cells, mensenchymal stem/stromal cells, neural precursors, oligodendrocyte progenitors, embryonic stem cells, and induced pluripotent stem cells...
March 17, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28303761/percutaneous-peripheral-nerve-stimulation-for-treatment-of-shoulder-pain-after-spinal-cord-injury-a-case-report
#11
Daniela Mehech, Melvin Mejia, Gregory A Nemunaitis, John Chae, Richard D Wilson
CONTEXT: This describes the first person with spinal cord injury (SCI) treated with percutaneous peripheral nerve stimulation for chronic shoulder pain. FINDINGS: From baseline to one-week after treatment, the subject's worst pain in the last week, rated on a 0-10 numerical rating scale (BPI-SF3), decreased by 44%. Pain interference decreased and remained below baseline 12 weeks after the end of treatment. There was an associated improvement in the mental component of quality of life...
March 17, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28302458/the-effects-of-dexmedetomidine-pretreatment-on-the-pro-and-anti-inflammation-systems-after-spinal-cord-injury-in-rats
#12
Hui Rong, Zhibin Zhao, Jiying Feng, Yishan Lei, Hao Wu, Rao Sun, Zuoxia Zhang, Bailing Hou, Wei Zhang, YuE Sun, Xiaoping Gu, Zhengliang Ma, Yue Liu
Excessive inflammatory responses play important roles in the aggravation of secondary damage to an injured spinal cord. Dexmedetomidine (DEX), a selective α2-adrenoceptor agonist, has recently been implied to be neuroprotective in clinical anesthesia, but the underlying mechanism is elusive. As signaling through Toll-like receptor 4 (TLR4) and nicotinic receptors (nAChRs, notably α7nAChR) play important roles in the pro- and anti-inflammation systems in the central nervous system, respectively, this study investigated whether and how they were modulated by DEX pretreatment in a rat model of spinal cord compression...
March 14, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28301253/efficacy-and-safety-of-varicocelectomies-a-meta-analysis
#13
Renbin Yuan, Hui Zhuo, Dehong Cao, Qiang Wei
This study reviewed the efficacy and safety of the three surgical approaches for varicocele (microsurgical, laparoscopic, and open varicocelectomy). A systematic review of the relevant randomized clinical trials was performed. Trials were identified from specialized trials register of the Cochrane UGDP Group, the Cochrane library, additional electronic searches (mainly MEDLINE, EMBSAE, SCI, CBM), and handsearching. Clinical trials comparing microsurgical, laparoscopic and open varicocelectomies were included...
April 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28298927/therapeutic-potential-of-olfactory-ensheathing-cells-and-mesenchymal-stem-cells-in-spinal-cord-injuries
#14
REVIEW
Zadroga Anna, Jezierska-Woźniak Katarzyna, Czarzasta Joanna, Monika Barczewska, Wojtkiewicz Joanna, Maksymowicz Wojciech
Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28298306/il-1%C3%AE-induces-nf-%C3%AE%C2%BAb-and-upregulates-microrna-372-to-inhibit-spinal-cord-injury-recovery
#15
Wei Zhou, Tongzhou Yuan, Youshui Gao, Peipei Yin, Wei Liu, Chenhao Pan, Yingjie Liu, Xiaowei Yu
Excessive inflammation including IL-1β-initiated signaling is among the earlies reactions that can cause neuronal damage following spinal cord injury (SCI). It has been suggested that microRNAs may participate in stem cell repair to facilitate functional recovery after SCI. Here we showed that in cultured human neural stem cells (hNSC) IL-1β reduced the expressions of both KIF3B (kinesin family member 3B) and NOSIP (nitric oxide synthase interacting protein), two key modulators for restricting inflammation and promoting neuronal regeneration...
March 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28298073/electro-acupuncture-modulated-mir-214-prevents-neuronal-apoptosis-by-targeting-bax-and-inhibits-sodium-channel-nav1-3-expression-in-rats-after-spinal-cord-injury
#16
Jing Liu, Yaochi Wu
Electro-acupuncture (EA) has been proven to contribute towards neurologic and functional recoveries in spinal cord injury (SCI), but the underlying mechanism remains largely unknown especially regarding the effects of preventing neuronal apoptosis and alleviating neuropathic pain involved in the development of EA. In this study, we evaluated the effect of EA treatment in an animal model of SCI using the Basso, Beattie, and Bresnahan (BBB) score method, lesion volume by cresyl violet staining and neuronal apoptosis by TUNEL staining...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28297672/identification-of-intrinsic-axon-growth-modulators-for-intact-cns-neurons-after-injury
#17
Kathren L Fink, Francesc López-Giráldez, In-Jung Kim, Stephen M Strittmatter, William B J Cafferty
Functional deficits persist after spinal cord injury (SCI) because axons in the adult mammalian central nervous system (CNS) fail to regenerate. However, modest levels of spontaneous functional recovery are typically observed after trauma and are thought to be mediated by the plasticity of intact circuitry. The mechanisms underlying intact circuit plasticity are not delineated. Here, we characterize the in vivo transcriptome of sprouting intact neurons from Ngr1 null mice after partial SCI. We identify the lysophosphatidic acid signaling modulators LPPR1 and LPAR1 as intrinsic axon growth modulators for intact corticospinal motor neurons after adjacent injury...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28296144/aligned-poly-%C3%AE%C2%B5-caprolactone-nanofibers-guide-the-orientation-and-migration-of-human-pluripotent-stem-cell-derived-neurons-astrocytes-and-oligodendrocyte-precursor-cells-in-vitro
#18
Anu Hyysalo, Mervi Ristola, Tiina Joki, Mari Honkanen, Minnamari Vippola, Susanna Narkilahti
Stem cell transplantations for spinal cord injury (SCI) have been studied extensively for the past decade in order to replace the damaged tissue with human pluripotent stem cell (hPSC)-derived neural cells. Transplanted cells may, however, benefit from supporting and guiding structures or scaffolds in order to remain viable and integrate into the host tissue. Biomaterials can be used as supporting scaffolds, as they mimic the characteristics of the natural cellular environment. In this study, hPSC-derived neurons, astrocytes, and oligodendrocyte precursor cells (OPCs) are cultured on aligned poly(ε-caprolactone) nanofiber platforms, which guide cell orientation to resemble that of spinal cord in vivo...
March 15, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28295674/skin-hydration-analysis-by-experiment-and-computer-simulations-and-its-implications-for-diapered-skin
#19
M Saadatmand, K J Stone, V N Vega, S Felter, S Ventura, G Kasting, J Jaworska
BACKGROUND: Experimental work on skin hydration is technologically challenging, and mostly limited to observations where environmental conditions are constant. In some cases, like diapered baby skin, such work is practically unfeasible, yet it is important to understand potential effects of diapering on skin condition. To overcome this challenge, in part, we developed a computer simulation model of reversible transient skin hydration effects. METHODS: Skin hydration model by Li et al...
March 13, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28294142/inosine-attenuates-spontaneous-activity-in-the-rat-neurogenic-bladder-through-an-a2b-pathway
#20
Claire Doyle, Vivian Cristofaro, Bryan S Sack, Stefan N Lukianov, Mattias Schäfer, Yeun Goo Chung, Maryrose P Sullivan, Rosalyn M Adam
Neurogenic detrusor overactivity (NDO) is among the most challenging complications of spinal cord injury (SCI). A recent report by us demonstrated an improvement in NDO in SCI rats following chronic systemic treatment with the purine nucleoside inosine. The objective of this study was to investigate the mechanism of action of inosine underlying improvement of NDO. Male Sprague-Dawley rats underwent complete spinal cord transection at T8. Inosine (1 mM) delivered intravesically to SCI rats during conscious cystometry significantly decreased the frequency of spontaneous non-voiding contractions...
March 15, 2017: Scientific Reports
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