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https://www.readbyqxmd.com/read/28096864/feline-dirofilariosis-due-to-dirofilaria-immitis-in-meshkin-shahr-district-northwestern-iran
#1
Mahya Khodabakhsh, Abdolali Malmasi, Mehdi Mohebali, Zabihollah Zarei, Eshrat Beigom Kia, Amrollah Azarm
BACKGROUND: Dirofilaria immitis is a common nematode of the cardiovascular system, which infects carnivores all over the world. The infection is prevalent in dogs, but in cats and human is rare. Dirofilariosis is transmitted by mosquitoes. Cats are accidental hosts and are naturally resistant to the infection, compared to the dogs. Mild infection can cause severe illness in cats and may lead to death, so it is clinically important to diagnose the disease. METHODS: In the present study, 103 stray cats were collected from Meshkin Shahr district, Aradabil Province, northwestern Iran that is an endemic area for canine dirofilariosis...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28077754/double-blinded-randomised-placebo-controlled-clinical-trial-of-individualised-homeopathic-treatment-of-hyperthyroid-cats
#2
A L Bodey, C J Almond, M A Holmes
Feline hyperthyroidism is a common endocrine disorder in older cats for which homeopathic treatment has been advocated. A double-blinded, placebo-controlled randomised trial was performed to look for evidence of efficacy for the use of individualised homeopathy in the treatment of this disease. Using a case definition of a concentration of the thyroid hormone T4 >66 nmol/l, cats were randomised into two treatment arms. Either a placebo or a homeopathic treatment was given to each cat blindly. After 21 days, the T4 levels, weight (Wt) and heart rate (HR) were compared with pretreatment values...
January 11, 2017: Veterinary Record
https://www.readbyqxmd.com/read/27997898/mechanisms-of-iherg-ikr-modulation-by-%C3%AE-1-adrenoceptors-in-hek293-cells-and-cardiac-myocytes
#3
Janire Urrutia, Aintzane Alday, Mónica Gallego, L Layse Malagueta-Vieira, Ivan Arael Aréchiga-Figueroa, Oscar Casis, José Antonio Sánchez-Chapula
BACKGROUND: The rapid delayed rectifier K+ current (IKr), carried by the hERG protein, is one of the main repolarising currents in the human heart and a reduction of this current increases the risk of ventricular fibrillation. α1-adrenoceptors (α1-AR) activation reduces IKr but, despite the clear relationship between an increase in the sympathetic tone and arrhythmias, the mechanisms underlying the α1-AR regulation of the hERG channel are controversial. Thus, we aimed to investigate the mechanisms by which α1-AR stimulation regulates IKr...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27973580/a-small-molecule-inhibitor-of-sarcomere-contractility-acutely-relieves-left-ventricular-outflow-tract-obstruction-in-feline-hypertrophic-cardiomyopathy
#4
Joshua A Stern, Svetlana Markova, Yu Ueda, Jae B Kim, Peter J Pascoe, Marc J Evanchik, Eric M Green, Samantha P Harris
Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle characterized by otherwise unexplained thickening of the left ventricle. Left ventricular outflow tract (LVOT) obstruction is present in approximately two-thirds of patients and substantially increases the risk of disease complications. Invasive treatment with septal myectomy or alcohol septal ablation can improve symptoms and functional status, but currently available drugs for reducing obstruction have pleiotropic effects and variable therapeutic responses...
2016: PloS One
https://www.readbyqxmd.com/read/27918152/computed-tomographic-characteristics-of-the-thyroid-glands-in-eight-hyperthyroid-cats-pre-and-postmethimazole-treatment-compared-with-seven-euthyroid-cats
#5
Jennifer L Bush, Sarah Nemanic, Jana Gordon, Gerd Bobe
Hyperthyroidism is the most common feline endocrinopathy; thyroid computed tomography (CT) may improve disease detection and methimazole dose selection. Objectives of this experimental pre-post with historical case-control study were to perform thyroid CT imaging in awake or mildly sedated hyperthyroid cats, compare thyroid gland CT appearance in euthyroid and hyperthyroid cats pre- and postmethimazole treatment, and determine whether thyroid size or attenuation correlate with methimazole dose needed for euthyroidism...
December 5, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27670935/determination-of-gestational-time-and-prediction-of-parturition-in-dogs-and-cats-an-update
#6
M Beccaglia, S Alonge, C Trovo', G C Luvoni
Accurate prediction of delivery date in canine and feline allows a better management of parturition, reducing the loss of neonates. This review evaluates the most common methods adopted to accurately predict the day of delivery: determination of ovulation and hormonal assays, first appearance of embryonic/foetal structures using ultrasound or radiography, echographic measurement of extra-foetal and foetal structures, or evaluation of foetal flux and heart rate. Determination of ovulation and hormonal assays at the time of breeding and close to pregnancy term is widely used to predict parturition in dogs (Concannon et al...
September 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27667689/right-ventricular-involvement-in-feline-hypertrophic-cardiomyopathy
#7
K E Schober, S I Savino, V Yildiz
OBJECTIVES: To evaluate right ventricular (RV) wall thickness and chamber dimensions in cats with hypertrophic cardiomyopathy (HCM). ANIMALS: One hundred fifty-one healthy control cats and 200 cats with HCM. METHODS: Retrospective, observational, clinical cohort study. Two-dimensional echocardiograms from all cats were analyzed. Right atrial diameter, RV free wall thickness, and RV chamber diameter were quantified using multiple imaging views...
December 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27576196/evaluation-of-feline-uterine-and-umbilical-arteries-blood-flow-in-a-pharmacologically-induced-abnormal-gestation-model
#8
P G Blanco, R Vercellini, A Rube, R Rodríguez, D O Arias, C Gobello
The aim of this study was to describe resistance index (RI) and systolic/diastolic ratio (S/D ratio) of uterine and umbilical arteries in an experimental model of abnormal pregnancy in felids. On days 30 to 35 (32 ± 2.9) after mating, 20 domestic short-hair pregnant queens were randomly assigned to one of the following treatment groups: a treated group (TG; n = 8), which received 10 mg/kg of aglepristone subcutaneously twice, 24 hours apart, and a control nontreated group (CG; n = 12). M-mode and Doppler ultrasonographic evaluations were performed at the initiation of the treatment (Day 0) and then every other day during 8 days...
December 2016: Theriogenology
https://www.readbyqxmd.com/read/27573384/effect-of-body-weight-on-echocardiographic-measurements-in-19-866-pure-bred-cats-with-or-without-heart-disease
#9
J Häggström, Å O Andersson, T Falk, L Nilsfors, U OIsson, J G Kresken, K Höglund, M Rishniw, A Tidholm, I Ljungvall
BACKGROUND: Echocardiography is a cost-efficient method to screen cats for presence of heart disease. Current reference intervals for feline cardiac dimensions do not account for body weight (BW). OBJECTIVE: To study the effect of BW on heart rate (HR), aortic (Ao), left atrial (LA) and ventricular (LV) linear dimensions in cats, and to calculate 95% prediction intervals for these variables in normal adult pure-bred cats. ANIMALS: 19 866 pure-bred cats...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27392420/pathological-features-and-pathogenesis-of-the-endomyocardial-form-of-restrictive-cardiomyopathy-in-cats
#10
Y Kimura, S Karakama, A Hirakawa, S Tsuchiaka, M Kobayashi, N Machida
This study reports pathological and molecular features in 41 cases of feline restrictive cardiomyopathy (RCM). Grossly, there were patchy or diffuse areas of endocardial thickening affecting the left ventricle. The more common patchy endocardial lesions occurred as large trabecular or irregular broad bands of fibrous tissue bridging the left ventricular free wall and ventricular septum. Microscopically, regardless of the gross pattern, the thickened endocardium contained various numbers of stellate, spindle-shaped or elongated mesenchymal cells surrounded by fibrous connective tissue...
August 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27371539/perianesthetic-mortality-in-domestic-animals-a-retrospective-study-of-postmortem-lesions-and-review-of-autopsy-procedures
#11
J DeLay
Autopsy of animals that die in the perianesthetic period allows identification of anesthetic and surgical complications as well as preexisting disease conditions that may have contributed to mortality. In most studies to date investigating perianesthetic mortality in animals, inclusion of autopsy data is very limited. This retrospective study evaluated autopsy findings in 221 cases of perianesthetic death submitted to a veterinary diagnostic laboratory from primary care and referral hospitals. Canine (n = 105; 48%) and feline (n = 90; 41%) cases predominated in the study, involving elective (71%) and emergency (19%) procedures...
September 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27283084/infective-endocarditis-in-13-cats
#12
Jean-Sébastien Palerme, Ashley E Jones, Jessica L Ward, Nandhakumar Balakrishnan, Keith E Linder, Edward B Breitschwerdt, Bruce W Keene
INTRODUCTION: To describe the clinical presentation, clinicopathological abnormalities and outcomes of a series of cats diagnosed with infective endocarditis (IE) at two tertiary care referral institutions. ANIMALS: Thirteen client-owned cats presenting to the cardiology or emergency services of tertiary referral institutions with a diagnosis of endocarditis based on the modified Duke criteria. MATERIALS AND METHODS: Retrospective case series...
September 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27270861/cryopreservation-20-%C3%A2-c-of-feline-corneoscleral-tissue-histologic-microbiologic-and-ultrastructural-study
#13
Daniel Costa, Marta Leiva, Carolina Naranjo, José Ríos, Maria Teresa Peña
OBJECTIVE: To evaluate microbiological, histologic, and ultrastructural characteristics of short-term cryopreserved (STC) feline corneoscleral tissue (<1 year) and to compare it with long-term cryopreserved (LTC) tissue (>7 years). ANIMALS STUDIED: Twenty healthy feline globes were obtained from 2003 to 2013. PROCEDURE: After a decontamination protocol, globes were enucleated and stored at -20 °C in broad-spectrum antibiotics. Corneoscleral tissue was evaluated at different storage periods: <1 year (10 eyes) and >7 years (8 eyes)...
July 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27225272/evaluation-of-red-blood-cell-distribution-width-as-a-prognostic-indicator-in-cats-with-acquired-heart-disease-with-and-without-congestive-heart-failure
#14
Kursten V Roderick, Amanda L Abelson, Lindsey Nielsen, Lori Lyn Price, Rebecca Quinn
OBJECTIVES: Congestive heart failure secondary to cardiomyopathy is a common manifestation of cardiac disease in cats, carrying a variable prognosis. The objective of this retrospective study is to evaluate the relationship between red blood cell distribution width (RDW) and survival time in feline patients with acquired heart disease with and without congestive heart failure (CHF). METHODS: Three hundred and forty-nine client-owned cats with echocardiograms and complete blood count, including RDW measurement, performed between March 2006 and December 2011, were included in the study...
May 25, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/26991029/effect-of-timolol-maleate-gel-forming-solution-on-intraocular-pressure-pupil-diameter-and-heart-rate-in-normal-and-glaucomatous-cats
#15
Julie A Kiland, Andrea M Voss, Gillian J McLellan
OBJECTIVE: To determine the effects of once-daily topical treatment with timolol maleate gel-forming solution (GFS) on intraocular pressure (IOP), pupil diameter (PD), and heart rate (HR) in normal cats and cats with feline primary congenital glaucoma (FCG). ANIMALS STUDIED AND PROCEDURES: A single drop of timolol maleate 0.5% GFS was administered topically to one randomly assigned eye of 18 adult cats (8 normal, 10 FCG) at 8 am for 8 days; the opposite eye served as the untreated control...
July 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/26914618/dexmedetomidine-as-a-sedative-in-the-awake-implantation-of-a-neuromodulative-system
#16
Feline F J A Ter Bruggen, Ismail Eralp, Leo Leliveld, Chris Jansen, Dirk L Stronks, Frank J P M Huygen
OBJECTIVE: During implantation of a neuromodulative system, high patient satisfaction is closely associated with the equilibrium between an effective analgesia and sedation regimen, and the possibility for the patient to be awake and cooperative during procedure. This study assessed the efficacy of the sedative dexmedetomidine to achieve this balance, with patient satisfaction as the primary outcome. METHODS: Ten patients undergoing implantation of a dorsal column and dorsal root ganglion stimulator received dexmedetomidine (1 mcg/kg over 10 minutes, followed by 0...
February 23, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/26785092/retention-curves-for-pediatric-and-neonatal-intubation-skills-after-simulation-based-training
#17
Pamela B Andreatta, Suzanne L Dooley-Hash, Jessica J Klotz, Joe G Hauptman, Bea Biddinger, Joseph B House
OBJECTIVES: We evaluated the retention of pediatric and neonatal intubation performance abilities of clinicians trained on a simulated or live tissue model at 3 intervals after initial training to assess competency degradation related to either training modality or retention interval. METHODS: We implemented a quasi-experimental design with purposive sampling to assess performance differences between 171 subjects randomly assigned to 1 of 3 intervals after initial training: 6 weeks, 18 weeks, or 52 weeks...
February 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/26776597/thoracic-radiography-in-the-cat-identification-of-cardiomegaly-and-congestive-heart-failure
#18
REVIEW
Carlo Guglielmini, Alessia Diana
Thoracic radiography is one of the most commonly employed diagnostic tools for the clinical evaluation of cats with suspected heart disease and is the standard diagnostic method in the confirmation of cardiogenic pulmonary edema. In the past, interpretation of feline radiographs focused on a description of the qualitative radiographic features of feline heart disease or the measurement of the cardiac silhouette in healthy cats and cats with different cardiovascular disorders. More recently, studies have begun to critically address the issue of the diagnostic accuracy of thoracic radiography in the diagnostic work-up of cats with heart disease...
December 2015: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/26776595/hypertrophic-cardiomyopathy-in-man-and-cats
#19
EDITORIAL
Barry J Maron, Philip R Fox
OBJECTIVES: To highlight similarities in hypertrophic cardiomyopathy (HCM) that are shared between humans and domestic cats. METHODS: Contemporary clinical and scientific findings were selected from the literature. Evidence is provided to support the concept that HCM in humans and felines are fundamentally the same disease. RESULTS: A number of remarkable similarities have been reported in certain spontaneously occurring myocardial disorders in domestic animals that closely resemble the clinical and phenotypic features of their corresponding diseases in humans...
December 2015: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/26776588/secondary-prevention-of-cardiogenic-arterial-thromboembolism-in-the-cat-the-double-blind-randomized-positive-controlled-feline-arterial-thromboembolism-clopidogrel-vs-aspirin-trial-fat-cat
#20
RANDOMIZED CONTROLLED TRIAL
Daniel F Hogan, Philip R Fox, Kristin Jacob, Bruce Keene, Nancy J Laste, Steven Rosenthal, Kimberly Sederquist, Hsin-Yi Weng
OBJECTIVES: To determine if clopidogrel administration is associated with a reduced likelihood of recurrent cardiogenic arterial thromboembolism (CATE) in cats compared to aspirin administration. Secondary aims were to determine if clopidogrel administration had an effect on the composite endpoint of recurrent CATE and cardiac death and to identify adverse effects of chronic clopidogrel or aspirin therapy. ANIMALS: Seventy-five cats that survived a CATE event. METHODS: Multicenter, double-blind, randomized, positive-controlled study...
December 2015: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
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