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https://www.readbyqxmd.com/read/28826266/prevalence-of-and-risk-factors-for-feline-hyperthyroidism-in-south-africa
#1
Joanne L McLean, Remo G Lobetti, Carmel T Mooney, Peter N Thompson, Johan P Schoeman
Objectives Hyperthyroidism is a disorder of older cats that may have a geographical variation in prevalence. Prevalence studies have not yet been performed in South Africa, a geographical area where hyperthyroidism in cats has recently been observed and where, reportedly, the incidence appears to be increasing. The purpose of this study was to determine the prevalence of feline hyperthyroidism in South Africa and to identify any potential risk factors. Further information on the worldwide prevalence and possible causative factors would increase our understanding of the aetiology of this disease and help identify any preventive measures...
December 1, 2016: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28804855/human-heart-failure-with-preserved-ejection-versus-feline-cardiomyopathy-what-can-we-learn-from-both-veterinary-and-human-medicine
#2
REVIEW
Valentine Prat, Bertrand Rozec, Chantal Gauthier, Benjamin Lauzier
Cardiovascular affections are a growing health burden in human populations. Recent advances in cardiology have improved treatments and outcomes for myocardial infarction and arrhythmias, but other conditions still remain poorly understood. To date, the classical approach to study cardiovascular diseases involves rodent models, despite their strong differences with human cardiac physiology. In this context, this review will focus on the common traits between human and feline cardiac diseases, namely heart failure with preserved ejection fraction and feline cardiomyopathies, respectively...
August 14, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28763158/frequency-and-number-of-b-lines-using-a-regionally-based-lung-ultrasound-examination-in-cats-with-radiographically-normal-lungs-compared-to-cats-with-left-sided-congestive-heart-failure
#3
Gregory R Lisciandro, Robert M Fulton, Geoffrey T Fosgate, Kelly A Mann
OBJECTIVE: To establish a baseline lung ultrasound (LUS) artifact profile using a regionally based protocol in cats without clinical signs of respiratory disease and with radiographically normal lungs compared to a cohort of cats with left-sided congestive heart failure (CHF). DESIGN: Prospective case series. ANIMALS: Forty-nine cats without clinical signs of respiratory disease and with radiographically normal lungs and 7 cats with radiographic evidence of left-sided CHF...
September 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28720299/cats-with-diabetes-mellitus-have-diastolic-dysfunction-in-the-absence-of-structural-heart-disease
#4
N J Pereira, J Novo Matos, M Baron Toaldo, U Bartoszuk, N Summerfield, A Riederer, C Reusch, T M Glaus
Diabetes mellitus (DM) can result in cardiovascular dysfunction and heart failure characterized by diastolic dysfunction with or without the presence of systolic dysfunction in people and laboratory animals. The objective of this prospective study was to determine if cats with newly diagnosed DM had myocardial dysfunction and, if present, whether it would progress if appropriate antidiabetic therapy was commenced. Thirty-two diabetic cats were enrolled and received baseline echocardiographic examination; of these, 15 cats were re-examined after 6 months...
July 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28647113/feline-congestive-heart-failure-current-diagnosis-and-management
#5
REVIEW
Etienne Côté
Congestive heart failure (CHF) is a well-known disorder in feline practice, having been recognized as the most common clinical syndrome in cats with hypertrophic cardiomyopathy, for example. This article identifies the reasons that an accurate diagnosis of CHF is important and the means by which to obtain one; pharmacologic and nonpharmacologic methods for controlling signs of CHF; and recommendations for follow-up evaluations, monitoring, and troubleshooting.
June 21, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28642712/investigations-into-the-sarcomeric-protein-and-ca-2-regulation-abnormalities-underlying-hypertrophic-cardiomyopathy-in-cats-felix-catus
#6
Andrew E Messer, Jasmine Chan, Alex Daley, O'Neal Copeland, Steven B Marston, David J Connolly
Hypertrophic cardiomyopathy (HCM) is the most common single gene inherited cardiomyopathy. In cats (Felix catus) HCM is even more prevalent and affects 16% of the outbred population and up to 26% in pedigree breeds such as Maine Coon and Ragdoll. Homozygous MYBPC3 mutations have been identified in these breeds but the mutations in other cats are unknown. At the clinical and physiological level feline HCM is closely analogous to human HCM but little is known about the primary causative mechanism. Most identified HCM causing mutations are in the genes coding for proteins of the sarcomere...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28622497/feline-panleukopenia-virus-is-not-associated-with-myocarditis-or-endomyocardial-restrictive-cardiomyopathy-in-cats
#7
Laura McEndaffer, Alex Molesan, Hollis Erb, Kathleen Kelly
Canine parvovirus-2 (CPV-2) is nearly indistinguishable from feline panleukopenia virus (FPV) and is a well-known cause of viral myocarditis in young puppies; however, it is not known whether either FPV or CPV-2 naturally infects feline cardiomyocytes and causes myocarditis. Endomyocarditis (EMC) and left ventricular endomyocardial fibrosis (LVEF), clinically known as "endomyocardial restrictive cardiomyopathy," are important feline heart diseases suspected to have an infectious etiology. A continuum is suggested with EMC representing the acute reaction to an unknown infectious agent and LVEF the chronic manifestation of repair...
July 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28592415/role-of-stim1-stromal-interaction-molecule-1-in-hypertrophy-related-contractile-dysfunction
#8
Constantine D Troupes, Markus Wallner, Giulia Borghetti, Chen Zhang, Sadia Mohsin, Dirk von Lewinski, Remus M Berretta, Hajime Kubo, Xiongwen Chen, Jonathan Soboloff, Steven Houser
RATIONALE: Pathological increases in cardiac afterload result in myocyte hypertrophy with changes in myocyte electrical and mechanical phenotype. Remodeling of contractile and signaling Ca(2+) occurs in pathological hypertrophy and is central to myocyte remodeling. STIM1 (stromal interaction molecule 1) regulates Ca(2+) signaling in many cell types by sensing low endoplasmic reticular Ca(2+) levels and then coupling to plasma membrane Orai channels to induce a Ca(2+) influx pathway. Previous reports suggest that STIM1 may play a role in cardiac hypertrophy, but its role in electrical and mechanical phenotypic alterations is not well understood...
July 7, 2017: Circulation Research
https://www.readbyqxmd.com/read/28495193/first-genetic-characterization-of-toxoplasma-gondii-in-stray-cats-from-algeria
#9
Feriel Yekkour, Dominique Aubert, Aurélien Mercier, Jean-Benjamin Murat, Mammar Khames, Paul Nguewa, Khatima Ait-Oudhia, Isabelle Villena, Zahida Bouchene
Toxoplasmosis is a parasitic disease with worldwide distribution and a major public health problem. In Algeria, no data are currently available about genotypes of Toxoplasma gondii isolated from animals or humans. The present study assesses for the first time the seroprevalence of toxoplasmosis in stray cats, and provides molecular characterization of T. gondii strains circulating in this feline population in Algiers, the capital city of Algeria. Sera from 96 stray cats were tested for the presence of antibodies against T...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28435002/systemic-arterial-hypertension-secondary-to-chronic-kidney-disease-in-two-captive-born-large-felids
#10
A Leclerc, E Trehiou-Sechi, E M Greunz, C Damoiseaux, J Bouvard, V Chetboul
Systemic arterial hypertension (SHT) has been widely described in the domestic cat (Felis catus). In these feline patients, SHT is considered as the most common vascular disorder of middle-aged to older animals, and secondary SHT related to chronic kidney disease (CKD) represents the most common form of the disease. We describe here the first two cases of spontaneous SHT in large felids, i.e. one 18-year old, 34.4 kg, male North-Chinese leopard (Panthera pardus japonensis, case #1) and one 20-year old, 28...
April 20, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28402392/caveolae-localized-l-type-ca2-channels-do-not-contribute-to-function-or-hypertrophic-signalling-in-the-mouse-heart
#11
Robert N Correll, Catherine A Makarewich, Hongyu Zhang, Chen Zhang, Michelle A Sargent, Allen J York, Remus M Berretta, Xiongwen Chen, Steven R Houser, Jeffery D Molkentin
Aims: L-type Ca2+ channels (LTCCs) in adult cardiomyocytes are localized to t-tubules where they initiate excitation-contraction coupling. Our recent work has shown that a subpopulation of LTCCs found at the surface sarcolemma in caveolae of adult feline cardiomyocytes can also generate a Ca2+ microdomain that activates nuclear factor of activated T-cells signaling and cardiac hypertrophy, although the relevance of this paradigm to hypertrophy regulation in vivo has not been examined...
June 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28320395/vasoproliferative-process-resembling-pulmonary-capillary-hemangiomatosis-in-a-cat
#12
J A Jaffey, K J Williams, I Masseau, M Krueger, C Reinero
BACKGROUND: Pulmonary capillary hemangiomatosis is a rare, vascular obstructive disorder that uniformly causes pulmonary arterial hypertension. Clinically, pulmonary capillary hemangiomatosis is indistinguishable from primary pulmonary arterial hypertension and histology is required for definitive diagnosis. The distinctive histologic feature of pulmonary capillary hemangiomatosis is non-malignant extensive proliferation of capillaries in the alveolar septae. Vasodilator treatment of humans with primary arterial hypertension due to pulmonary capillary hemangiomatosis can result in fatal acute pulmonary edema...
March 20, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28317615/routine-screening-examinations-in-attendance-of-cats-with-obstructive-lower-urinary-tract-disease
#13
REVIEW
Amanda Marin Neri, Luiz Henrique de Araújo Machado, Priscylla Tatiana Chalfun Guimarães Okamoto, Maurício Gianfrancesco Filippi, Regina Kiomi Takahira, Alessandra Melchert, Maria Lúcia Gomes Lourenço
This study evaluates the clinical findings obtained in routine screening examinations in cats with obstructive feline lower urinary tract disease at the time of service. Twenty-six cats with urethral obstruction were assessed by physical examination, blood pressure, electrocardiogram, and laboratory tests. Cats with signs of obstruction less than 36 hours before the service were in a state of alert, with body temperature and heart rate higher compared with cats in lethargy and stupor, obstructed up to 36 hours...
December 2016: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/28295648/echocardiographic-assessment-of-right-ventricular-size-and-function-in-cats-with-hypertrophic-cardiomyopathy
#14
L C Visser, C Q Sloan, J A Stern
BACKGROUND: Studies evaluating right ventricular (RV) structural and functional abnormalities in feline hypertrophic cardiomyopathy (HCM) are limited. HYPOTHESIS: Right ventricular structural and functional abnormalities are present in cats with HCM and are associated with clinical severity. ANIMALS: Eighty-one client-owned cats. METHODS: Retrospective 2-dimensional (2D) echocardiographic study. Right atrial diameter (RAD), RV free wall thickness (RVFWd), RV internal dimension (RVIDd), RV fractional area change (FAC), and tricuspid annular plane systolic excursion (TAPSE) were measured in control cats (n = 26), cats with subclinical HCM (subclinical HCM; n = 31), and cats with HCM and congestive heart failure (HCM + CHF; n = 24)...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28245741/isfm-consensus-guidelines-on-the-diagnosis-and-management-of-hypertension-in-cats
#15
Samantha S Taylor, Andrew H Sparkes, Katherine Briscoe, Jenny Carter, Salva Cervantes Sala, Rosanne E Jepson, Brice S Reynolds, Brian A Scansen
Practical relevance: Feline hypertension is a common disease in older cats that is frequently diagnosed in association with other diseases such as chronic kidney disease and hyperthyroidism (so-called secondary hypertension), although some cases of apparent primary hypertension are also reported. The clinical consequences of hypertension can be severe, related to 'target organ damage' (eye, heart and vasculature, brain and kidneys), and early diagnosis followed by appropriate therapeutic management should help reduce the morbidity associated with this condition...
March 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28238868/seroprevalence-isolation-and-co-infection-of-multiple-toxoplasma-gondii-strains-in-individual-bobcats-lynx-rufus-from-mississippi-usa
#16
Shiv K Verma, Amy R Sweeny, Matthew J Lovallo, Rafael Calero-Bernal, Oliver C Kwok, Tiantian Jiang, Chunlei Su, Michael E Grigg, Jitender P Dubey
Toxoplasma gondii causes lifelong chronic infection in both feline definitive hosts and intermediate hosts. Multiple exposures to the parasite are likely to occur in nature due to high environmental contamination. Here, we present data of high seroprevalence and multiple T. gondii strain co-infections in individual bobcats (Lynx rufus). Unfrozen samples (blood, heart, tongue and faeces) were collected from 35 free ranging wild bobcats from Mississippi, USA. Toxoplasma gondii antibodies were detected in serum by the modified agglutination test (1:≥200) in all 35 bobcats...
April 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28213270/myocardial-leptin-transcription-in-feline-hypertrophic-cardiomyopathy
#17
Sonja Fonfara, Sarah Kitz, Udo Hetzel, Anja Kipar
Leptin is an adipokine, which is in humans with cardiac disease suspected to be involved in myocardial remodeling and thrombus formation. In cats, however, it is not known whether leptin plays a role in cardiac disease, i.e. hypertrophic cardiomyopathy (HCM) and the presence of an atrial thrombus (AT). The objective of the study was therefore to establish whether leptin is transcribed in the feline myocardium and to compare myocardial leptin mRNA concentrations in cats with HCM with and without AT, and in cats without cardiac diseases...
February 13, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28096864/feline-dirofilariosis-due-to-dirofilaria-immitis-in-meshkin-shahr-district-northwestern-iran
#18
Mahya Khodabakhsh, Abdolali Malmasi, Mehdi Mohebali, Zabihollah Zarei, Eshrat Beigom Kia, Amrollah Azarm
BACKGROUND: Dirofilaria immitis is a common nematode of the cardiovascular system, which infects carnivores all over the world. The infection is prevalent in dogs, but in cats and human is rare. Dirofilariosis is transmitted by mosquitoes. Cats are accidental hosts and are naturally resistant to the infection, compared to the dogs. Mild infection can cause severe illness in cats and may lead to death, so it is clinically important to diagnose the disease. METHODS: In the present study, 103 stray cats were collected from Meshkin Shahr district, Aradabil Province, northwestern Iran that is an endemic area for canine dirofilariosis...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28077754/double-blinded-randomised-placebo-controlled-clinical-trial-of-individualised-homeopathic-treatment-of-hyperthyroid-cats
#19
RANDOMIZED CONTROLLED TRIAL
A L Bodey, C J Almond, M A Holmes
Feline hyperthyroidism is a common endocrine disorder in older cats for which homeopathic treatment has been advocated. A double-blinded, placebo-controlled randomised trial was performed to look for evidence of efficacy for the use of individualised homeopathy in the treatment of this disease. Using a case definition of a concentration of the thyroid hormone T4 >66 nmol/l, cats were randomised into two treatment arms. Either a placebo or a homeopathic treatment was given to each cat blindly. After 21 days, the T4 levels, weight (Wt) and heart rate (HR) were compared with pretreatment values...
April 15, 2017: Veterinary Record
https://www.readbyqxmd.com/read/27997898/mechanisms-of-iherg-ikr-modulation-by-%C3%AE-1-adrenoceptors-in-hek293-cells-and-cardiac-myocytes
#20
Janire Urrutia, Aintzane Alday, Mónica Gallego, L Layse Malagueta-Vieira, Ivan Arael Aréchiga-Figueroa, Oscar Casis, José Antonio Sánchez-Chapula
BACKGROUND: The rapid delayed rectifier K+ current (IKr), carried by the hERG protein, is one of the main repolarising currents in the human heart and a reduction of this current increases the risk of ventricular fibrillation. α1-adrenoceptors (α1-AR) activation reduces IKr but, despite the clear relationship between an increase in the sympathetic tone and arrhythmias, the mechanisms underlying the α1-AR regulation of the hERG channel are controversial. Thus, we aimed to investigate the mechanisms by which α1-AR stimulation regulates IKr...
2016: Cellular Physiology and Biochemistry
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