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https://www.readbyqxmd.com/read/29773810/cardiovascular-disease-risk-varies-by-birth-month-in-canines
#1
Mary Regina Boland, Marc S Kraus, Eddie Dziuk, Anna R Gelzer
The canine heart is a robust physiological model for the human heart. Recently, birth month associations have been reported and replicated in humans using clinical health records. While animals respond readily to their environment in the wild, a systematic investigation of birth season dependencies among pets and specifically canines remains lacking. We obtained data from the Orthopedic Foundation of Animals on 129,778 canines representing 253 distinct breeds. Among canines that were not predisposed to cardiovascular disease, a clear birth season relationship is observed with peak risk occurring in June-August...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29753687/istaroxime-a-positive-inotropic-agent-devoid-of-proarrhythmic-properties-in-sensitive-chronic-atrioventricular-block-dogs
#2
Alexandre Bossu, Amée Kostense, Henriette D M Beekman, Marien J C Houtman, Marcel A G van der Heyden, Marc A Vos
Current inotropic agents in heart failure therapy associate with low benefit and significant adverse effects, including ventricular arrhythmias. Istaroxime, a novel Na+ /K+ -transporting ATPase inhibitor, also stimulates SERCA2a activity, which would confer improved inotropic and lusitropic properties with less proarrhythmic effects. We investigated hemodynamic, electrophysiological and potential proarrhythmic and antiarrhythmic effects of istaroxime in control and chronic atrioventricular block (CAVB) dogs sensitive to drug-induced Torsades de Pointes arrhythmias (TdP)...
May 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29748220/remote-left-ventricular-hemodynamic-monitoring-using-a-novel-intracardiac-sensor
#3
Thomas Mondritzki, Philip Boehme, Jason White, Jin Woo Park, Jessica Hoffmann, Julia Vogel, Peter Kolkhof, Stuart Walsh, Peter Sandner, Erwin Bischoff, Wilfried Dinh, Jörg Hüser, Hubert Truebel
BACKGROUND: Heart failure (HF) remains the most common reason for hospital admission in patients aged >65 years. Despite modern drug therapy, mortality and readmission rates for patients hospitalized with HF remain high. This necessitates further research to identify early patients at risk for readmission to limit hospitalization by timely adjustment of medical therapy. Implantable devices can monitor left ventricular (LV) hemodynamics and remotely and continuously detect the early signs of decompensation to trigger interventions and reduce the risk of hospitalization for HF...
May 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29680382/phenotypic-description-of-cardiac-findings-in-a-population-of-dogue-de-bordeaux-with-an-emphasis-on-atrial-fibrillation
#4
G McAulay, K Borgeat, J Sargent, P Mõtsküla, J Neves, J Dukes-McEwan, V Luis Fuentes
The aim of this study was to describe the clinical phenotype of Dogue de Bordeaux (DdB) referred for cardiac investigation, with particular reference to the prevalence of atrial fibrillation and associated features. Review of canine medical records of two United Kingdom veterinary referral hospitals identified 64 DdB with available echocardiographic and electrocardiographic (ECG)/Holter data. Atrial fibrillation was documented in 25 (39%) dogs and supraventricular tachycardia was recorded in five (7.8%) dogs...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29665072/an-update-on-canine-cardiomyopathies-is-it-all-in-the-genes
#5
REVIEW
E Dutton, J López-Alvarez
Dilated cardiomyopathy is the second most common cardiac disease in dogs and causes considerable morbidity and mortality. Primary dilated cardiomyopathy is suspected to be familial, and genetic loci have been associated with the disease in a number of breeds. Because it is an adult-onset disease, usually with late onset, testing breeding dogs and bitches before breeding for a genetic mutation that could lead to dilated cardiomyopathy would be helpful to prevent disease. There is growing evidence that the genetic basis may be multigenic rather than monogenic in the majority of studied breeds...
April 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29663941/using-the-oculocardiac-reflex-to-characterize-autonomic-imbalance-in-a-naturally-occurring-canine-model-of-valvular-insufficiency
#6
Bruna C Brüler, Thayane C Vieira, Marcela Wolf, Stephany B Lucina, Fabiano Montiani-Ferreira, Marlos G Sousa
Congestive heart failure (CHF) is characterized by reduced heart rate variability. Although various methods to achieve parasympathetic withdrawal and sympathetic activation have been documented, stimulation of the vagal nerve (that is, vagal maneuvers) has not often been used to assess the autonomic impairment associated with disease progression in veterinary species. In this study, we investigated cardiac autonomic control in a naturally occurring canine model of mitral insufficiency by means of individual responses to oculocardiac reflex...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29651618/effect-of-renal-sympathetic-denervation-on-ventricular-and-neural-remodeling
#7
L Wang, G Wei, L Song, C Li, F Zhang, Y Yang, C Lu
BACKGROUND: This study assessed the therapeutic effects of renal sympathetic denervation (RDN) on post-myocardial infarction (MI) ventricular remodeling and sympathetic neural remodeling in dogs. The possible mechanisms and optimal time for treatment are discussed. METHODS: We randomly assigned 30 dogs to five groups: RDN 1 week before MI (RDN1w + MI; n = 6), RDN 1 week after MI (MI1w + RDN; n = 6), RDN 2 weeks after MI (MI2w + RDN; n = 6), control (N; n = 6), and MI (n = 6)...
April 12, 2018: Herz
https://www.readbyqxmd.com/read/29627686/sissr-simultaneous-subdivision-surface-registration-for-the-quantification-of-cardiac-function-from-computed-tomography-in-canines
#8
Davis M Vigneault, Amir Pourmorteza, Marvin L Thomas, David A Bluemke, J Alison Noble
Recent improvements in cardiac computed tomography (CCT) allow for whole-heart functional studies to be acquired at low radiation dose (<2mSv) and high-temporal resolution (<100ms) in a single heart beat. Although the extraction of regional functional information from these images is of great clinical interest, there is a paucity of research into the quantification of regional function from CCT, contrasting with the large body of work in echocardiography and cardiac MR. Here we present the Simultaneous Subdivision Surface Registration (SiSSR) method: a fast, semi-automated image analysis pipeline for quantifying regional function from contrast-enhanced CCT...
March 29, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29621066/electrical-stimulation-based-renal-nerve-mapping-exacerbates-ventricular-arrhythmias-during-acute-myocardial-ischaemia
#9
Bing Huang, Xiaoya Zhou, Menglong Wang, Xuefei Li, Liping Zhou, Guannan Meng, Yuhong Wang, Zhuo Wang, Songyun Wang, Lilei Yu, Hong Jiang
OBJECTIVE: Blood pressure elevation in response to transient renal nerve stimulation (RNS) has been used to determine the ablation target and endpoint of renal denervation. This study aimed to evaluate the safety of transient RNS in canines with normal or ischaemic hearts. METHODS: In ten normal (Group 1) and six healed myocardial infarction (HMI) (Group 2) canines, a large-tip catheter was inserted into the left or right renal artery to perform transient RNS. The left stellate ganglion neural activity (LSGNA) and ventricular electrophysiological parameters were measured at baseline and during transient RNS...
April 4, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29618477/characteristics-of-ice-impedance-recorded-from-a-ring-electrode-placed-at-the-anterior-surface-of-the-cryoballoon-novel-approach-to-define-ice-formation-and-pulmonary-vein-isolation
#10
Boaz Avitall, Arthur Kalinski, G Stephen Kocheril, Ken S Lizama, Nicolas Coulombe, Timothy Laske
BACKGROUND: The success of cryoablation of the pulmonary vein isolation (PVI) is dependent on transmural and circumferential ice formation. We hypothesize that rising impedance recorded from a ring electrode placed 2 mm from the cryoballoon signifies ice formation covering the balloon surface and indicates ice expansion. The impedance level enables titration of the cryoapplication time to avoid extracardiac damage while ensuring PVI. METHODS AND RESULTS: In 12 canines, a total of 57 pulmonary veins were targeted for isolation...
April 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29582428/selective-late-sodium-current-inhibitor-gs-458967-suppresses-torsades-de-pointes-by-mostly-affecting-perpetuation-but-not-initiation-of-the-arrhythmia
#11
Alexandre Bossu, Marien J C Houtman, Veronique M F Meijborg, Rosanne Varkevisser, Henriette D M Beekman, Albert Dunnink, Jacques M T de Bakker, Nevena Mollova, Sridharan Rajamani, Luiz Belardinelli, Marcel A G van der Heyden, Marc A Vos
BACKGROUND AND PURPOSE: Enhanced late sodium current (late INa ) in heart failure and long QT syndrome type 3 is proarrhythmic. GS-458967 (GS967) is a selective and potent late INa inhibitor. This study aimed to evaluate the antiarrhythmic effect of late INa inhibition by GS967 in the chronic atrioventricular block (CAVB) dog model sensitive to Torsade de Pointes arrhythmias (TdP) and to elucidate its electrophysiological mode of action in vivo and in vitro. METHODS - RESULTS: GS967 (IC50 for late INa ~ 200 nM) markedly shortened action potential duration of canine ventricular cardiomyocytes and repolarization parameters in vivo in sinus rhythm (SR, n=10) dogs, in a concentration-dependent manner...
March 27, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29573742/systemic-inflammation-in-dogs-with-advanced-stage-heart-failure
#12
Aleksandra Domanjko Petrič, Tajda Lukman, Barbara Verk, Alenka Nemec Svete
BACKGROUND: Although human studies have shown that inflammation plays a role in the development of congestive heart failure, scarce information exists on white blood cell count (WBC) and differential cell counts in various stages of heart failure in man and dogs. A few studies demonstrated increased concentrations of C-reactive protein (CRP), a major acute-phase protein, in cardiac diseases in dogs. Our research aimed to investigate whether CRP concentration, WBC and neutrophil count (NEUT), as markers of systemic inflammation, are elevated in canine cardiovascular patients...
March 24, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29534991/microtubular-remodeling-and-decreased-expression-of-nav1-5-with-enhanced-ehd4-in-cells-from-the-infarcted-heart
#13
Wen Dun, Peter Danilo, Peter J Mohler, Penelope A Boyden
Cardiac Na+ channel remodeling provides a critical substrate for generation of reentrant arrhythmias in border zones of the infarcted canine heart. Recent studies show that Nav1.5 cytoskeletal- and endosomal-based membrane trafficking and function are linked to tubulin, microtubular (MT) networks, and Eps15 homology domain containing proteins like EHD4. AIM: Our objective is to understand the relation of tubulin and EHD4 to Nav 1.5 channel protein remodeling observed in border zone cells (IZs) when arrhythmias are known to occur; that is, 3-h, 48-h and 5-day post coronary occlusion...
May 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29530679/serum-proteome-profiling-in-canine-idiopathic-dilated-cardiomyopathy-using-tmt-based-quantitative-proteomics-approach
#14
Petra Bilić, Nicolas Guillemin, Alan Kovačević, Blanka Beer Ljubić, Ines Jović, Asier Galan, Peter David Eckersall, Richard Burchmore, Vladimir Mrljak
Idiopathic dilated cardiomyopathy (iDCM) is a primary myocardial disorder with an unknown aetiology, characterized by reduced contractility and ventricular dilation of the left or both ventricles. Naturally occurring canine iDCM was used herein to identify serum proteomic signature of the disease compared to the healthy state, providing an insight into underlying mechanisms and revealing proteins with biomarker potential. To achieve this, we used high-throughput label-based quantitative LC-MS/MS proteomics approach and bioinformatics analysis of the in silico inferred interactome protein network created from the initial list of differential proteins...
May 15, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29483093/desmin-phosphorylation-triggers-preamyloid-oligomers-formation-and-myocyte-dysfunction-in-acquired-heart-failure
#15
Peter P Rainer, Peihong Dong, Matteo Sorge, Justyna Fert-Bober, Ronald J Holewinski, Yuchuan Wang, Catherine A Foss, Steven S An, Alessandra Baracca, Giancarlo Solaini, Charles G Glabe, Martin G Pomper, Jennifer E Van Eyk, Gordon F Tomaselli, Nazareno Paolocci, Giulio Agnetti
RATIONALE: Disrupted proteostasis is one major pathological trait that heart failure (HF) shares with other organ proteinopathies, such as Alzheimer and Parkinson diseases. Yet, differently from the latter, whether and how cardiac preamyloid oligomers (PAOs) develop in acquired forms of HF is unclear. OBJECTIVE: We previously reported a rise in monophosphorylated, aggregate-prone desmin in canine and human HF. We now tested whether monophosphorylated desmin acts as the seed nucleating PAOs formation and determined whether positron emission tomography is able to detect myocardial PAOs in nongenetic HF...
May 11, 2018: Circulation Research
https://www.readbyqxmd.com/read/29469965/vitamin-d-receptor-expression-in-dogs
#16
J A Cartwright, A G Gow, E Milne, D Drummond, S Smith, I Handel, R J Mellanby
BACKGROUND: There is growing evidence linking low blood vitamin D concentration to numerous diseases in people and in dogs. Vitamin D influences cellular function by signaling through the vitamin D receptor (VDR). Little is known about which non-skeletal tissues express the VDR or how inflammation influences its expression in the dog. OBJECTIVES: To define which non-skeletal canine tissues express the VDR and to investigate expression in inflamed small intestine...
March 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29444631/accumulation-of-laforin-and-other-related-proteins-in-canine-lafora-disease-with-epm2b-repeat-expansion
#17
James K Chambers, Atigan Thongtharb, Takanori Shiga, Daigo Azakami, Miyoko Saito, Masumi Sato, Motoji Morozumi, Hiroyuki Nakayama, Kazuyuki Uchida
Canine Lafora disease (LD) is an autosomal recessive genetic disorder causing nonfatal structural epilepsy, mainly affecting miniature wirehaired dachshunds. Repeat expansion in the EPM2B gene causes a functional impairment of the ubiquitin ligase malin which regulates glycogen metabolism. Abnormally structured glycogen accumulates and develop polyglucosan bodies predominantly in the central nervous system. The authors performed a comprehensive clinical, genetic, and pathological study of 4 LD cases affecting miniature wirehaired dachshund dogs with EPM2B repeat expansions, with systemic distribution of polyglucosan bodies and accumulation of laforin and other functionally associated proteins in the polyglucosan bodies...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29428540/in-vitro-assessment-of-the-interactions-of-dopamine-%C3%AE-hydroxylase-inhibitors-with-human-p-glycoprotein-and-breast-cancer-resistance-protein
#18
Joana Bicker, Gilberto Alves, Ana Fortuna, Patrício Soares-da-Silva, Amílcar Falcão
Inhibition of the biosynthesis of noradrenaline is a currently explored strategy for the treatment of hypertension, congestive heart failure and pulmonary arterial hypertension. While some dopamine β-hydroxylase (DBH) inhibitors cross the blood-brain barrier (BBB) and cause central as well as peripheral effects (nepicastat), others have limited access to the brain (etamicastat, zamicastat). In this context, peripheral selectivity is clinically advantageous, in order to prevent alterations of noradrenaline levels in the CNS and the occurrence of adverse central effects...
May 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29428085/evaluation-of-genes-associated-with-human-myxomatous-mitral-valve-disease-in-dogs-with-familial-myxomatous-mitral-valve-degeneration
#19
K M Meurs, S G Friedenberg, B Williams, B W Keene, C E Atkins, D Adin, B Aona, T DeFrancesco, S Tou, T Mackay
Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is believed to be heritable in Cavalier King Charles spaniels (CKCS) and Dachshunds. Myxomatous mitral valve disease is a familial disease in human beings as well and genetic mutations have been associated with its development. We hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated with the development of canine MMVD. DNA was isolated from blood samples from 10 CKCS and 10 Dachshunds diagnosed with MMVD, and whole genome sequences from each animal were obtained...
February 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29398674/canine-case-of-swallowing-syncope-that-improved-after-pacemaker-implantation
#20
Ryuji Fukushima, Toshiki Araie, Naoaki Itou, Takae Kawaguchi, Shusaku Yamada, Aritada Yoshimura, Seijirow Goya, Kazumi Shimada, Tsuyoshi Uchide, Miori Kishimoto, Noboru Machida
A 14-year-old intact male West Highland White Terrier weighing 6.9 kg was admitted to the Tokyo University of Agriculture and Technology Animal Medical Center with the complaint of syncope after showing signs of nausea during feeding. Sinus arrest induced by deglutition was confirmed using a Holter electrocardiography test. However, the clinical symptoms significantly improved after implantation of a permanent pacemaker. Seven months after implantation, the dog died from acute pancreatitis, a cause unrelated to the syncope...
March 24, 2018: Journal of Veterinary Medical Science
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