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https://www.readbyqxmd.com/read/27906545/temperature-dependent-inotropic-and-lusitropic-indices-based-on-half-logistic-time-constants-for-four-segmental-phases-in-isovolumic-left-ventricular-pressure-time-curve-in-excised-cross-circulated-canine-heart
#1
Ju Mizuno, Satoshi Mohri, Takeshi Yokoyama, Mikiya Otsuji, Hideko Arita, Kazuo Hanaoka
Varying temperature affects cardiac systolic and diastolic function and the left ventricular (LV) pressure-time curve (PTC) waveform that includes information about LV inotropism and lusitropism. Our proposed half-logistic (h-L) time constants obtained by fitting using h-L functions for four segmental phases (Phases I-IV) in the isovolumic LV PTC are more useful indices for estimating LV inotropism and lusitropism during contraction and relaxation periods than the mono-exponential (m-E) time constants at normal temperature...
September 5, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27906096/biological-and-functional-evaluation-of-a-novel-pyrolytic-carbon-implant-for-the-treatment-of-focal-osteochondral-defects-in-the-medial-femoral-condyle-assessment-in-a-canine-model
#2
Samantha L Salkeld, Laura P Patron, Joan C Lien, Stephen D Cook, Deryk G Jones
BACKGROUND: Osteochondral defects continue to be a clinical treatment challenge, and when left untreated, may cause pain and functional impairment. Pyrolytic carbon is a unique isotropic biomaterial used in heart valve and small joint replacements due to its excellent wear properties and biocompatibility with bone and articular cartilage. Therefore, a proposed solution is to utilize a focal pyrolytic carbon hemiarthroplasty implant as an alternative resurfacing treatment strategy for isolated cartilage lesions...
December 1, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27891565/expression-and-biochemical-characteristics-of-two-different-aldosterone-receptors-in-both-healthy-and-dilated-cardiomyopathy-dog-heart-tissue
#3
Alejandro R Reynoso Palomar, Moncerrat Rodriguez Bravo, Abel E Villa Mancera, Carlos J Mucha
Recently, replicates of the aldosterone receptor expression have been done in healthy heart dog tissues through immunohistochemistry, showing an apparent heterogeneous distribution in the four chambers. Recent studies have also identified immediate effects of aldosterone, suggesting aldosterone also produces non-genomic effects caused by an unidentified receptor. In order to study the molecular and quantitative expression characteristics of aldosterone binding receptors in the canine heart, we conducted studies, using Western Blot, in the heart from both healthy animals and animals with dilated cardiomyopathy...
November 28, 2016: Veterinary Research Communications
https://www.readbyqxmd.com/read/27876986/prevalence-and-pathological-lesions-of-ovine-cysticercosis-in-slaughtered-sheep-in-western-iran
#4
Mohammad Hashemnia, Yasser Shahbazi, Ghasem Frajani Kish
Cysticercusovis, the intermediate stage of a canine tapeworm, Taenia ovis, produces cystic lesions in the skeletal and cardiac muscle of sheep which, if numerous, will result in the condemnation of an entire carcass. This study was carried out between March 2013 and March 2014 to estimate the prevalence of Taenia oviscysticercosis in sheep slaughtered at the Kermanshah municipal abattoir, in western Iran. Of 69,198 sheep examined, 833 (1.27 %) were infected with cysticerci of Taenia ovis. The prevalence of C...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27853102/cardiac-safety-profile-of-sildenafil-chronotropic-inotropic-and-coronary-vasodilator-effects-in-the-canine-isolated-blood-perfused-heart-preparations
#5
Nur Jaharat Lubna, Yuji Nakamura, Xin Cao, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama
Sildenafil is a phosphodiesterase type-5 inhibitor. We evaluated the effects of sildenafil on the sinoatrial rate, developed tension of the papillary muscle and coronary blood flow by using the canine isolated, blood-perfused sinoatrial node and papillary muscle preparations. The former preparation had a regular automaticity rate of 106 ± 1 beats/min (n = 4), whereas the latter showed a developed tension of 22 ± 4 mN (n = 4) and a coronary blood flow of 3.9 ± 0.1 mL/min (n = 4). Intracoronary injection of 10, 30 and 100 µg of sildenafil, which would provide about 20 to 200 times higher plasma drug concentrations than its therapeutic level, increased the automaticity rate by 4, 12 and 22%, the developed tension by 19, 55 and 118% and the coronary blood flow by 42, 95 and 142%, respectively...
2016: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/27831864/3d-myocardial-elastography-in-vivo
#6
Clement Papadacci, Ethan A Bunting, Elaine Y Wan, Pierre Nauleau, Elisa E Konofagou
Strain evaluation is of major interest in clinical cardiology as it can quantify the cardiac function. Myocardial elastography, a radio-frequency (RF)-based cross-correlation method, has been developed to evaluate the local strain distribution in the heart in vivo. However, inhomogeneities such as RF ablation lesions or infarction require a three-dimensional approach to be measured accurately. In addition, acquisitions at high volume rate are essential to evaluate the cardiac strain in three dimensions. Conventional focused transmit schemes using 2D matrix arrays, trade off sufficient volume rate for beam density or sector size to image rapid moving structure such as the heart, which lowers accuracy and precision in the strain estimation...
November 1, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27818454/vidarabine-an-anti-herpes-virus-agent-protects-against-the-development-of-heart-failure-with-relatively-mild-side-effects-on-cardiac-function-in-a-canine-model-of-pacing-induced-dilated-cardiomyopathy
#7
Takashi Nakamura, Takayuki Fujita, Megumi Kishimura, Kenji Suita, Yuko Hidaka, Wenqian Cai, Masanari Umemura, Utako Yokoyama, Masami Uechi, Yoshihiro Ishikawa
BACKGROUND: In heart failure patients, chronic hyperactivation of sympathetic signaling is known to exacerbate cardiac dysfunction. In this study, the cardioprotective effect of vidarabine, an anti-herpes virus agent, which we identified as a cardiac adenylyl cyclase inhibitor, in dogs with pacing-induced dilated cardiomyopathy (DCM) was evaluated. In addition, the adverse effects of vidarabine on basal cardiac function was compared to those of the β-blocker, carvedilol.Methods and Results:Vidarabine and carvedilol attenuated the development of pacing-induced systolic dysfunction significantly and with equal effectiveness...
November 5, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27816306/intravenous-electrical-vagal-nerve-stimulation-prior-to-coronary-reperfusion-in-a-canine-ischemia-reperfusion-model-markedly-reduces-infarct-size-and-prevents-subsequent-heart-failure
#8
Takahiro Arimura, Keita Saku, Takamori Kakino, Takuya Nishikawa, Takeshi Tohyama, Takafumi Sakamoto, Kazuo Sakamoto, Takuya Kishi, Tomomi Ide, Kenji Sunagawa
BACKGROUND: Reducing myocardial damage is a prerequisite to prevent chronic heart failure after acute myocardial infarction (AMI). Although vagal nerve stimulation (VNS) has been repeatedly demonstrated to have potent anti-infarct effect, technical difficulties have precluded its clinical application. We developed a novel therapeutic strategy of intravenous VNS (iVNS) and examined whether iVNS administered prior to coronary reperfusion in a canine AMI model reduces infarct size and prevents heart failure...
October 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27807888/uterine-haemodynamic-vascularization-and-blood-pressure-changes-along-the-oestrous-cycle-in-bitches
#9
I B Nogueira, L L Almeida, Dsr Angrimani, M M Brito, R A Abreu, C I Vannucchi
Characterization of the bitch's reproductive physiology is of utmost importance for the development of new reproductive techniques and the diagnosis of reproductive diseases. In this respect, uterine B-mode ultrasonography has been employed in several studies; however, the focus on haemodynamic changes along the oestrous cycle is yet to be described. Thus, the aim of this study was to characterize haemodynamic changes (uterine vascularization, systemic arterial blood pressure and heart rate) throughout the oestrous cycle in bitches...
November 3, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27782003/electromechanical-wave-imaging-ewi-validation-in-all-four-cardiac-chambers-with-3d-electroanatomic-mapping-in-canines-in-vivo
#10
Alexandre Costet, Elaine Wan, Ethan Bunting, Julien Grondin, Hasan Garan, Elisa Konofagou
Characterization and mapping of arrhythmias is currently performed through invasive insertion and manipulation of cardiac catheters. Electromechanical wave imaging (EWI) is a non-invasive ultrasound-based imaging technique, which tracks the electromechanical activation that immediately follows electrical activation. Electrical and electromechanical activations were previously found to be linearly correlated in the left ventricle, but the relationship has not yet been investigated in the three other chambers of the heart...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27779469/dose-dependent-electrophysiological-effects-of-the-myosin-activator-omecamtiv-mecarbil-in-canine-ventricular-cardiomyocytes
#11
N Szentandrassy, B Horvath, K Vaczi, K Kistamas, L Masuda, J Magyar, T Banyasz, Z Papp, P P Nanasi
Omecamtiv mecarbil (OM) is a myosin activator agent recently developed for treatment of heart failure. Although its action on extending systolic ejection time and increasing left ventricular ejection fraction is well documented, no data is available regarding its possible side-effects on cardiac ion channels. Therefore, the present study was designed to investigate the effects of OM on action potential morphology and the underlying ion currents in isolated canine ventricular myocytes using sharp microelectrodes, conventional patch clamp, and action potential voltage clamp techniques...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27760722/corrigendum-to-gentile-solomon-jm-abbott-ja-conventional-echocardiographic-assessment-of-the-canine-right-heart-reference-intervals-and-repeatability-j-vet-cardiol-18-3-2016-234-247
#12
J M Gentile-Solomon, J A Abbott
No abstract text is available yet for this article.
October 16, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27759180/beating-heart-validation-of-safety-and-efficacy-of-a-percutaneous-pericardiotomy-tool
#13
Ammar M Killu, Niyada Naksuk, Christopher V Desimone, Prakriti Gaba, Scott Suddendorf, Joanne Powers, Dejae Ladewig, Lilach O Lerman, Barry A Borlaug, Samuel J Asirvatham
INTRODUCTION: Epicardial procedures frequently require pericardial manipulation. We aimed to develop a nonsurgical percutaneous pericardial modification tool that may (1) facilitate epicardial-based procedures by enabling adhesiolysis or (2) attenuate the myocardial constraining effect of the pericardium. METHODS: Three novel devices were developed to enable pericardiotomy, all of which can be deployed in over-the-wire fashion following percutaneous epicardial access...
October 19, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27758811/left-atrial-remodeling-and-atrioventricular-coupling-in-a-canine-model-of-early-heart-failure-with-preserved-ejection-fraction
#14
Rosita Zakeri, Gilles Moulay, Qiang Chai, Ozgur Ogut, Saad Hussain, Hiroyuki Takahama, Tong Lu, Xiao-Li Wang, Wolfgang A Linke, Hon-Chi Lee, Margaret M Redfield
BACKGROUND: Left atrial (LA) compliance and contractility influence left ventricular stroke volume. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. METHODS AND RESULTS: Cardiac magnetic resonance imaging, echocardiography, left ventricular and LA pressure-volume studies, and tissue analyses were performed in a model of early HFpEF (elderly dogs, renal wrap-induced hypertension, exogenous aldosterone; n=9) and young control dogs (sham surgery; n=13)...
October 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27733623/nebulette-is-a-powerful-cytolinker-organizing-desmin-and-actin-in-mouse-hearts
#15
Daniel A Hernandez, Christina M Bennett, Lyubov Dunina-Barkovskaya, Tatjana Wedig, Yassemi Capetanaki, Harald Herrmann, Gloria M Conover
In the hearts of patients bearing nebulette mutations, a severe general disorganization in cardiomyocytes of the extrasarcomeric desmin intermediate filament system is frequently observed. However, the molecular and functional relationship between the desmin cytoskeleton and nebulette-containing sarcomeres is still unclear. Here we report a high-affinity in vitro interaction between nebulette and desmin filaments. A major interaction site has been mapped to the desmin α-helical rod domain, indicating that the filament core is directly involved in the binding of nebulette...
December 1, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27700266/epidemiological-clinical-and-echocardiographic-features-and-survival-times-of-dogs-and-cats-with-tetralogy-of-fallot-31-cases-2003-2014
#16
Valérie Chetboul, Isabelle Pitsch, Renaud Tissier, Vassiliki Gouni, Charlotte Misbach, Emilie Trehiou-Sechi, Amandine M Petit, Cécile Damoiseaux, Jean-Louis Pouchelon, Loïc Desquilbet, Eric Bomassi
OBJECTIVE To characterize the epidemiological, clinical, and echocardiographic features of dogs and cats with tetralogy of Fallot (TOF) and determine their survival times. DESIGN Retrospective case series. ANIMALS 15 dogs and 16 cats with a diagnosis of TOF as determined via echocardiography. PROCEDURES Medical records of dogs and cats were reviewed to extract information on signalment, clinical status at the time of TOF diagnosis, echocardiographic findings, and any outcome data. RESULTS The most common canine breeds were terrier types (n = 7)...
October 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27677086/-comparison-of-ultrasound-guided-femoral-and-sciatic-nerve-block-versus-epidural-anaesthesia-for-orthopaedic-surgery-in-dogs
#17
Mareike Arnholz, Stephan Hungerbühler, Clarissa Weil, Alexandra F Schütter, Karl Rohn, Julia Tünsmeyer, Sabine B R Kästner
OBJECTIVE: Comparison of ultrasound-guided femoral and sciatic nerve block versus epidural anaesthesia with bupivacaine and morphine for orthopaedic surgery of the pelvic limb in dogs with respect to analgesic effectiveness, clinical utility and side effects. MATERIAL AND METHODS: The study included 22 dogs (American Society of Anesthesiologists, ASA grades I and II) undergoing orthopaedic surgery distal to the mid-femoral bone. The study was designed as a randomized, prospective, blinded clinical trial...
September 27, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27670935/determination-of-gestational-time-and-prediction-of-parturition-in-dogs-and-cats-an-update
#18
M Beccaglia, S Alonge, C Trovo', G C Luvoni
Accurate prediction of delivery date in canine and feline allows a better management of parturition, reducing the loss of neonates. This review evaluates the most common methods adopted to accurately predict the day of delivery: determination of ovulation and hormonal assays, first appearance of embryonic/foetal structures using ultrasound or radiography, echographic measurement of extra-foetal and foetal structures, or evaluation of foetal flux and heart rate. Determination of ovulation and hormonal assays at the time of breeding and close to pregnancy term is widely used to predict parturition in dogs (Concannon et al...
September 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27644192/efficacy-of-pimobendan-on-survival-and-reoccurrence-of-pulmonary-edema-in-canine-congestive-heart-failure
#19
Masashi Mizuno, Shigeki Yamano, Shuichi Chimura, Atsushi Hirakawa, Yoshimi Ukai, Tamotsu Sawada, Shigeki Maetani, Arane Takahashi, Takeshi Mizuno, Kayoko Harada, Asako Shinoda, Shuhei Uchida, Junichiro Takeuchi, Takahiro Mizukoshi, Masaaki Endo, Masami Uechi
The aim of this study was to evaluate the efficacy of pimobendan with conventional therapies on survival and reocurrence of pulmonary edema in dogs with congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD). Records of 197 client-owned dogs from 14 veterinary hospitals were included in this study. Dogs were administered conventional treatments with or without pimobendan. Sixty-four dogs received a standard dose of pimobendan (0.20-0.48 mg/kg every 12 hr (q12hr)), 49 dogs received a low dose of pimobendan (0...
September 17, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27614226/interaction-between-the-muscle-metaboreflex-and-the-arterial-baroreflex-in-control-of-arterial-pressure-and-skeletal-muscle-blood-flow
#20
Jasdeep Kaur, Alberto Alvarez, Hanna W Hanna, Abhinav C Krishnan, Danielle Senador, Tiago M Machado, Yasir H Altamimi, Abe T Lovelace, Maryetta D Dombrowski, Marty D Spranger, Donal S O'Leary
The muscle metaboreflex and arterial baroreflex regulate arterial pressure through distinct mechanisms. During submaximal exercise muscle metaboreflex activation (MMA) elicits a pressor response virtually solely by increasing cardiac output (CO) while baroreceptor unloading increases mean arterial pressure (MAP) primarily through peripheral vasoconstriction. The interaction between the two reflexes when activated simultaneously has not been well established. We activated the muscle metaboreflex in chronically instrumented canines during dynamic exercise (via graded reductions in hindlimb blood flow; HLBF) followed by simultaneous baroreceptor unloading (via bilateral carotid occlusion; BCO)...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
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