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https://www.readbyqxmd.com/read/28299636/asymptomatic-heart-valve-dysfunction-in-healthy-middle-aged-companion-dogs-and-its-implications-for-cardiac-aging
#1
Silvan R Urfer, Tammi L Kaeberlein, Susan Mailheau, Philip J Bergman, Kate E Creevy, Daniel E L Promislow, Matt Kaeberlein
Heart disease is the leading cause of death in the USA, accounting for about one in every four deaths. Age is the greatest risk factor for heart disease in both people and dogs; however, heart disease is generally not considered as a major cause of morbidity or mortality in dogs. As part of the preliminary selection process for a veterinary clinical trial, 40 companion dogs with no history of cardiac pathology that were at least 6 years old and weighed at least 18 kg underwent a cardiac screening using Doppler echocardiography...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28296006/intracoronary-allogeneic-cardiosphere-derived-stem-cells-are-safe-for-use-in-dogs-with-dilated-cardiomyopathy
#2
Michael Taylor Hensley, Junnan Tang, Kathleen Woodruff, Teresa Defrancesco, Sandra Tou, Christina M Williams, Mathew Breen, Kathryn Meurs, Bruce Keene, Ke Cheng
Cardiosphere-derived cells (CDCs) have been shown to reduce scar size and increase viable myocardium in human patients with mild/moderate myocardial infarction. Studies in rodent models suggest that CDC therapy may confer therapeutic benefits in patients with non-ischaemic dilated cardiomyopathy (DCM). We sought to determine the safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM. Canine CDCs (cCDCs) were grown from a donor dog heart. Similar to human CDCs, cCDCs express CD105 and are slightly positive for c-kit and CD90...
March 15, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28289990/dual-contrast-agent-photon-counting-computed-tomography-of-the-heart-initial-experience
#3
Rolf Symons, Tyler E Cork, Manu N Lakshmanan, Robert Evers, Cynthia Davies-Venn, Kelly A Rice, Marvin L Thomas, Chia-Ying Liu, Steffen Kappler, Stefan Ulzheimer, Veit Sandfort, David A Bluemke, Amir Pourmorteza
To determine the feasibility of dual-contrast agent imaging of the heart using photon-counting detector (PCD) computed tomography (CT) to simultaneously assess both first-pass and late enhancement of the myocardium. An occlusion-reperfusion canine model of myocardial infarction was used. Gadolinium-based contrast was injected 10 min prior to PCD CT. Iodinated contrast was infused immediately prior to PCD CT, thus capturing late gadolinium enhancement as well as first-pass iodine enhancement. Gadolinium and iodine maps were calculated using a linear material decomposition technique and compared to single-energy (conventional) images...
March 13, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28282234/breed-specific-vertebral-heart-scale-for-the-dachshund
#4
Ryan Birks, Deborah M Fine, Stacey B Leach, Sarah E Clay, Bryan D Eason, Lisa G Britt, Kenneth E Lamb
The objectives of this study were to determine a breed-specific vertebral heart scale (VHS) range for the dachshund and compare results to the established reference range of 9.7 ± 0.5, calculate inter-observer variability, and correlate VHS with echocardiography. Fifty-one normal dachshunds had radiographs and an echocardiogram performed. Five observers measured VHS to the nearest 0.25 vertebra. The data was analyzed using one-way analysis of variance, Wilcoxon Rank Sum test, Mann-Whitney rank sum test, calculation of reference and confidence intervals, Spearman rank-order correlations, and generation of intra-class correlations and confidence intervals...
March 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28270595/differential-responses-of-rabbit-ventricular-and-atrial-transient-outward-current-ito-to-the-ito-modulator-ns5806
#5
Hongwei Cheng, Mark B Cannell, Jules C Hancox
Transient outward potassium current (Ito) in the heart underlies phase 1 repolarization of cardiac action potentials and thereby affects excitation-contraction coupling. Small molecule activators of Ito may therefore offer novel treatments for cardiac dysfunction, including heart failure and atrial fibrillation. NS5806 has been identified as a prototypic activator of canine Ito This study investigated, for the first time, actions of NS5806 on rabbit atrial and ventricular Ito Whole cell patch-clamp recordings of Ito and action potentials were made at physiological temperature from rabbit ventricular and atrial myocytes...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28238671/cardiac-autonomic-ganglia-ablation-suppresses-atrial-fibrillation-in-a-canine-model-of-acute-intermittent-hypoxia
#6
Xiaomei Yu, Zhibing Lu, Wenbo He, Bo He, Ruisong Ma, Jing Xie, Hong Jiang
BACKGROUND: Atrial fibrillation (AF) is associated with hypoxia in which cardiac autonomic nerve system (ANS) plays an important role. Our previous studies indicated that ANS is activated in an intermittent hypoxia model and contributes to AF initiation. This study aimed to investigate the effects of cardiac ganglionated plexus (GP) ablation on AF in this model. METHODS AND RESULTS: In thirteen anesthetized male dogs, GP ablation was applied after 1h of intermittent hypoxia in the first group (n=7) and before that in the second group (n=6)...
February 23, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28212603/effects-of-renal-denervation-on-cardiac-oxidative-stress-and-local-activity-of-the-sympathetic-nervous-system-and-renin-angiotensin-system-in-acute-myocardial-infracted-dogs
#7
Qiaoli Feng, Chengzhi Lu, Li Wang, Lijun Song, Chao Li, Ravi Chandra Uppada
BACKGROUND: This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action. METHODS: Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded...
February 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28183991/cardiac-and-respiratory-motion-correction-for-simultaneous-cardiac-pet-mr
#8
Christoph Kolbitsch, Mark A Ahlman, Cynthia Davies-Venn, Robert Evers, Michael Hansen, Devis Peressutti, Paul Marsden, Peter Kellman, David A Bluemke, Tobias Schaeffter
Cardiac Positron Emission Tomography (PET) is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the heart can strongly impair image quality and therefore diagnostic accuracy of cardiac PET scans. The aim of this study is to investigate a new cardiac PET-Magnetic Resonance (MR) approach providing respiratory and cardiac motion-compensated MR and PET images in less than five minutes. Methods: Free-breathing 3D MR data was acquired and retrospectively binned into multiple respiratory and cardiac motion states...
February 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28176614/acanthomatous-ameloblastoma-with-atypical-foci-in-five-dogs
#9
Jennifer L Malmberg, Elizabeth W Howerth, Barb E Powers, Paula A Schaffer
Acanthomatous ameloblastoma is a common, locally invasive, nonmetastasizing tumor of the canine oral cavity. The long-term prognosis for canine acanthomatous ameloblastoma is good if complete excision can be achieved, usually by maxillectomy or mandibulectomy. A variant of acanthomatous ameloblastoma with atypical foci was noted in 5 dogs. There was no age, breed, or sex predisposition. Atypical cells were pleomorphic with a high mitotic rate. They were immunohistochemically negative for cytokeratin, vimentin, melan A, PNL2, CD3, Pax5, CD18, chromogranin A, and synaptophysin...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28154461/evaluation-of-serum-myeloperoxidase-concentration-in-dogs-with-heart-failure-due-to-chronic-mitral-valvular-insufficiency
#10
Jong-In Park, Sang-Il Suh, Changbaig Hyun
Myeloperoxidase (MPO) is a leukocyte-derived enzyme involved in the process of heart failure and is found to have good diagnostic and prognostic values in humans with chronic heart failure. This study evaluated the relationship between serum MPO levels and the severity of heart failure (HF) due to chronic mitral valvular insufficiency (CMVI) in dogs. Eighty-two client-owned dogs consisting of 69 dogs with different stages of HF due to CMVI and 13 age-matched healthy dogs were enrolled in this study. Serum MPO concentrations in the healthy and CMVI groups were determined by enzyme-linked immunosorbent assay (ELISA) using a canine-specific monoclonal anti-MPO antibody...
January 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28127817/effect-of-cardiac-resynchronization-therapy-on-myocardial-fibrosis-and-relevant-cytokines-in-a-canine-model-with-experimental-heart-failure
#11
Jingfeng Wang, Xue Gong, Haiyan Chen, Shengmei Qin, Nianwei Zhou, Yangang Su, Junbo Ge
INTRODUCTION: Though cardiac resynchronization therapy(CRT) has now proved to be effective on cardiac reverse remodeling, data on the underlying molecular changes are limited. The present study aims to investigate the expression of cytokines concerning myocardial fibrosis in dyssynchronous heart failure (HF) and the potential benefits of CRT. METHODS AND RESULTS: Left bundle branch ablation and rapid pacing was performed to induce a canine model of asynchronous HF...
January 27, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28126497/acute-effects-of-multisite-biventricular-pacing-on-dyssynchrony-and-hemodynamics-in-canines-with-heart-failure
#12
Qiong Qiu, Li Yang, Jing-Ting Mai, Ying Yang, Yong Xie, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Multisite biventricular pacing(MSP) has been proposed as an alternative strategy to improve the efficiency of conventional biventricular pacing(BVP), but its utility remains unclear. This study sought to investigate whether MSP induced better synchrony and hemodynamic effects in canines with heart failure. METHODS AND RESULTS: After 3 weeks' rapid right ventricular pacing(RVP), 7 canines were sutured with 4 left ventricular(LV) leads on anterior, lateral, posterior and apical wall, and followed by MSP and BVP...
January 23, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28096864/feline-dirofilariosis-due-to-dirofilaria-immitis-in-meshkin-shahr-district-northwestern-iran
#13
Mahya Khodabakhsh, Abdolali Malmasi, Mehdi Mohebali, Zabihollah Zarei, Eshrat Beigom Kia, Amrollah Azarm
BACKGROUND: Dirofilaria immitis is a common nematode of the cardiovascular system, which infects carnivores all over the world. The infection is prevalent in dogs, but in cats and human is rare. Dirofilariosis is transmitted by mosquitoes. Cats are accidental hosts and are naturally resistant to the infection, compared to the dogs. Mild infection can cause severe illness in cats and may lead to death, so it is clinically important to diagnose the disease. METHODS: In the present study, 103 stray cats were collected from Meshkin Shahr district, Aradabil Province, northwestern Iran that is an endemic area for canine dirofilariosis...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28095511/epidemiology-and-molecular-typing-of-trypanosoma-cruzi-in-naturally-infected-hound-dogs-and-associated-triatomine-vectors-in-texas-usa
#14
Rachel Curtis-Robles, Karen F Snowden, Brandon Dominguez, Lewis Dinges, Sandy Rodgers, Glennon Mays, Sarah A Hamer
BACKGROUND: Trypanosoma cruzi is the etiologic agent of Chagas disease throughout the Americas. Few population-level studies have examined the epidemiology of canine infection and strain types of T. cruzi that infect canines in the USA. We conducted a cross-sectional study of T. cruzi infection in working hound dogs in south central Texas, including analysis of triatomine vectors collected within kennel environments. METHODOLOGY/PRINCIPLE FINDINGS: Paired IFA and Chagas Stat-Pak serological testing showed an overall seroprevalence of 57...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28086779/the-effect-of-electrical-conductivity-of-myocardium-on-cardiac-pumping-efficacy-a-computational-study
#15
Ana Rahma Yuniarti, Ki Moo Lim
BACKGROUND AND AIMS: The existence of non-excitable cells in the myocardium leads to the increasing conduction non-uniformity and decreasing myocardial electrical conductivity. Slowed myocardial conduction velocity (MCV) believed to enhance the probability of cardiac arryhthmia and alter the cardiac mechanical pumping efficacy, even in sinus rhythm. Though several studies on the correlation between MCV and cardiac electrical instabilities exist, there has been no study concerning correlation or causality between MCV and cardiac mechanical pumping efficacy, due to the limitation in clinical methods to document and evaluate cardiac mechanical responses directly...
January 10, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28079862/extra-neuronal-pathology-in-a-canine-model-of-cln2-neuronal-ceroid-lipofuscinosis-after-intracerebroventricular-gene-therapy-that-delays-neurological-disease-progression
#16
M L Katz, G C Johnson, S B Leach, B G Williamson, J R Coates, R E H Whiting, D P Vansteenkiste, M S Whitney
CLN2 neuronal ceroid lipofuscinosis is a hereditary lysosomal storage disease with primarily neurological signs that results from mutations in TPP1 which encodes the lysosomal enzyme tripeptidyl peptidase-1 (TPP1). Studies using a canine model for this disorder demonstrated that delivery of TPP1 enzyme to the cerebrospinal fluid (CSF) by intracerebroventricular administration of an AAV-TPP1 vector resulted in substantial delays in the onset and progression of neurological signs and prolongation of lifespan...
January 12, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28070608/xuebijing-injection-treatment-inhibits-vasopermeability-and-reduces-fluid-requirements-in-a-canine-burn-model
#17
F-B Tang, Y-L Dai, S Hu, L-Q Ma, J-Y Li, H-P Zhang, W-H Zhang, Y-G Li, H-B Wang, H-Y Lin, Q Hu, L Li
OBJECTIVE: High vasopermeability and excessive inflammation following severe burns may result in tissue edema, organ dysfunction and the loss of circulatory plasma volume, which can influence the doctor to do the prognosis to the patients. The study aims to examine whether Xuebijing injection (XBJ), an extracts of a traditional Chinese medicine used to treat sepsis in clinic, can reduces fluid requirements by inhibiting vasopermeability and tissue edema in a canine model after burn injury...
January 9, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28046380/we-fg-202-06-the-use-of-hybrid-pet-mri-for-identifying-the-presence-of-cardiac-inflammation-following-external-beam-irradiation
#18
O El-Sherif, I Xhaferllari, J Sykes, J Butler, J Battista, G Wisenberg, F Prato, S Gaede
PURPOSE: To monitor the evolution of radiation-induced cardiac inflammation in a canine model using hybrid positron emission tomography (PET/magnetic resonance imaging (MRI). METHODS: Research ethics approval was obtained for a longitudinal imaging study of 5 canines after cardiac irradiation. Animals were imaged at baseline, 3 months, 6 months, and 12 months post cardiac irradiation using a hybrid PET-MRI system (Biograph mMR, Siemens Healthcare). The imaging protocol was designed to assess changes in cardiac inflammation using (18) F-fluorodeoxyglucose ((18) F-FDG) PET tracer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032399/increased-leptin-and-leptin-receptor-expression-in-dogs-with-gallbladder-mucocele
#19
S Lee, O-K Kweon, W H Kim
BACKGROUND: Leptin and its receptor play a role in several disease processes such as pancreatitis and heart disease. However, their association with gallbladder mucocele (GBM) in dogs has not been reported. HYPOTHESIS/OBJECTIVES: To evaluate differences in the expression of leptin and leptin receptor between dogs with and without GBM. ANIMALS: Twenty-five healthy dogs, including 9 laboratory beagle dogs, and 22 client-owned dogs with GBM. METHODS: Serum leptin concentration was determined in blood samples of all dogs by ELISA...
January 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28030338/lethal-angiostrongylus-vasorum-infection-in-a-hungarian-dog
#20
Tibor Benda, Ágnes Csivincsik, Csaba Nemes, Janka Turbók, Attila Zsolnai, Erika Simonyai, Gábor Majoros, Gábor Nagy
During post-mortem examination of lungs and heart of a 7-month-old female French bulldog, 158 worms were collected from the lung vessels and they proved Angiostrongylus vasorum by their morphological and genetic identification by PCR. The histopathological investigation found a multifocal interstitial inflammation characterized by numerous lymphocytes and a smaller number of plasma cells and eosinophils whilst L1 stage larvae could be seen inside dilated alveoli. We suggested a lethal angiostrongylosis supposed to lead to a fatal effect...
March 1, 2017: Acta Parasitologica
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