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Canine heart

J M Gentile-Solomon, J A Abbott
No abstract text is available yet for this article.
October 16, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Ammar M Killu, Niyada Naksuk, Christopher V Desimone, Prakriti Gaba, Scott Suddendorf, Joanne Powers, Dejae Ladewig, Lilach O Lerman, Barry A Borlaug, Samuel J Asirvatham
INTRODUCTION: Epicardial procedures frequently require pericardial manipulation. We aimed to develop a nonsurgical percutaneous pericardial modification tool that may (1) facilitate epicardial-based procedures by enabling adhesiolysis or (2) attenuate the myocardial constraining effect of the pericardium. METHODS: Three novel devices were developed to enable pericardiotomy, all of which can be deployed in over-the-wire fashion following percutaneous epicardial access...
October 19, 2016: Journal of Cardiovascular Electrophysiology
Rosita Zakeri, Gilles Moulay, Qiang Chai, Ozgur Ogut, Saad Hussain, Hiroyuki Takahama, Tong Lu, Xiao-Li Wang, Wolfgang A Linke, Hon-Chi Lee, Margaret M Redfield
BACKGROUND: Left atrial (LA) compliance and contractility influence left ventricular stroke volume. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. METHODS AND RESULTS: Cardiac magnetic resonance imaging, echocardiography, left ventricular and LA pressure-volume studies, and tissue analyses were performed in a model of early HFpEF (elderly dogs, renal wrap-induced hypertension, exogenous aldosterone; n=9) and young control dogs (sham surgery; n=13)...
October 2016: Circulation. Heart Failure
Daniel A Hernandez, Christina M Bennett, Lyubov Dunina-Barkovskaya, Tatjana Wedig, Yassemi Capetanaki, Harald Herrmann, Gloria M Conover
In the hearts of patients bearing nebulette mutations, a severe general disorganization in cardiomyocytes of the extrasarcomeric desmin intermediate filament system is frequently observed. However, the molecular and functional relationship between the desmin cytoskeleton and nebulette-containing sarcomeres is still unclear. Here we report a high-affinity in vitro interaction between nebulette and desmin filaments. A major interaction site has been mapped to the desmin α-helical rod domain indicating that the filament core is directly involved in the binding of nebulette...
October 12, 2016: Molecular Biology of the Cell
Valérie Chetboul, Isabelle Pitsch, Renaud Tissier, Vassiliki Gouni, Charlotte Misbach, Emilie Trehiou-Sechi, Amandine M Petit, Cécile Damoiseaux, Jean-Louis Pouchelon, Loïc Desquilbet, Eric Bomassi
OBJECTIVE To characterize the epidemiological, clinical, and echocardiographic features of dogs and cats with tetralogy of Fallot (TOF) and determine their survival times. DESIGN Retrospective case series. ANIMALS 15 dogs and 16 cats with a diagnosis of TOF as determined via echocardiography. PROCEDURES Medical records of dogs and cats were reviewed to extract information on signalment, clinical status at the time of TOF diagnosis, echocardiographic findings, and any outcome data. RESULTS The most common canine breeds were terrier types (n = 7)...
October 15, 2016: Journal of the American Veterinary Medical Association
Mareike Arnholz, Stephan Hungerbühler, Clarissa Weil, Alexandra F Schütter, Karl Rohn, Julia Tünsmeyer, Sabine B R Kästner
OBJECTIVE: Comparison of ultrasound-guided femoral and sciatic nerve block versus epidural anaesthesia with bupivacaine and morphine for orthopaedic surgery of the pelvic limb in dogs with respect to analgesic effectiveness, clinical utility and side effects. MATERIAL AND METHODS: The study included 22 dogs (American Society of Anesthesiologists, ASA grades I and II) undergoing orthopaedic surgery distal to the mid-femoral bone. The study was designed as a randomized, prospective, blinded clinical trial...
September 27, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
M Beccaglia, S Alonge, C Trovo', G C Luvoni
Accurate prediction of delivery date in canine and feline allows a better management of parturition, reducing the loss of neonates. This review evaluates the most common methods adopted to accurately predict the day of delivery: determination of ovulation and hormonal assays, first appearance of embryonic/foetal structures using ultrasound or radiography, echographic measurement of extra-foetal and foetal structures, or evaluation of foetal flux and heart rate. Determination of ovulation and hormonal assays at the time of breeding and close to pregnancy term is widely used to predict parturition in dogs (Concannon et al...
September 2016: Reproduction in Domestic Animals, Zuchthygiene
Masashi Mizuno, Shigeki Yamano, Shuichi Chimura, Atsushi Hirakawa, Yoshimi Ukai, Tamotsu Sawada, Shigeki Maetani, Arane Takahashi, Takeshi Mizuno, Kayoko Harada, Asako Shinoda, Shuhei Uchida, Junichiro Takeuchi, Takahiro Mizukoshi, Masaaki Endo, Masami Uechi
The aim of this study was to evaluate the efficacy of pimobendan with conventional therapies on survival and reocurrence of pulmonary edema in dogs with congestive heart failure (CHF) caused by myxomatous mitral valve disease (MMVD). Records of 197 client-owned dogs from 14 veterinary hospitals were included in this study. Dogs were administered conventional treatments with or without pimobendan. Sixty-four dogs received a standard dose of pimobendan (0.20-0.48 mg/kg every 12 hr (q12hr)), 49 dogs received a low dose of pimobendan (0...
September 17, 2016: Journal of Veterinary Medical Science
Jasdeep Kaur, Alberto Alvarez, Hanna W Hanna, Abhinav C Krishnan, Danielle Senador, Tiago M Machado, Yasir H Altamimi, Abe T Lovelace, Maryetta D Dombrowski, Marty D Spranger, Donal O'Leary
The muscle metaboreflex and arterial baroreflex regulate arterial pressure through distinct mechanisms. During submaximal exercise muscle metaboreflex activation (MMA) elicits a pressor response virtually solely by increasing cardiac output (CO) while baroreceptor unloading increases mean arterial pressure (MAP) primarily through peripheral vasoconstriction. The interaction between the two reflexes when activated simultaneously has not been well established. We activated the muscle metaboreflex in chronically instrumented canines during dynamic exercise (via graded reductions in hindlimb blood flow; HLBF) followed by simultaneous baroreceptor unloading (via bilateral carotid occlusion; BCO)...
September 9, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Sang Eon Park, Na-Yeon Jung, Na Kyung Lee, Jeongmin Lee, Brian Hyung, Su Hyeon Myeong, Hyeong Seop Kim, Yeon-Lim Suh, Jung-Il Lee, Kyung Rae Cho, Do Hyung Kim, Soo Jin Choi, Jong Wook Chang, Duk L Na
In this study, we investigated the distribution of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) administered via intracerebroventricular (ICV) injection in a canine model. Ten beagles (11-13 kg per beagle) each received an injection of 1 × 10(6) cells into the right lateral ventricle and were sacrificed 7 days after administration. Based on immunohistochemical analysis, hUCB-MSCs were observed in the brain parenchyma, especially along the lateral ventricular walls. Detected as far as 3...
August 12, 2016: Neurobiology of Aging
Jan Němec
Repolarization alternans precedes certain types of ventricular arrhythmias and its presence may be prognostically useful, but some ventricular arrhythmias are not preceded by repolarization alternans. Nonalternans changes of ventricular repolarization occur in patients with coronary artery disease and in subjects with congenital long QT syndrome. In animal experiments, nonalternans repolarization lability occurs in a canine model of chronic AV block with propensity to polymorphic ventricular tachycardia, in the perfused rabbit heart exposed to IKr block, and in a murine model of catecholaminergic polymorphic ventricular tachycardia...
August 17, 2016: Journal of Electrocardiology
Fady Dawoud, Karl H Schuleri, David D Spragg, B Milan Horáček, Ronald D Berger, Henry R Halperin, Albert C Lardo
INTRODUCTION: The interplay between electrical activation and mechanical contraction patterns is hypothesized to be central to reduced effectiveness of cardiac resynchronization therapy (CRT). Furthermore, complex scar substrates render CRT less effective. We used novel cardiac computed tomography (CT) and noninvasive electrocardiographic imaging (ECGI) techniques in an ischemic dyssynchronous heart failure (DHF) animal model to evaluate electrical and mechanical coupling of cardiac function, tissue viability, and venous accessibility of target pacing regions...
August 30, 2016: Journal of Cardiovascular Electrophysiology
A Russell Moore, Emily Coffey, Sarah E Leavell, Greta Krafsur, Colleen Duncan, Kristy Dowers, Kelly S Santangelo
A 6-year-old, male castrated, mixed-breed dog was referred to the James L. Voss Veterinary Teaching Hospital at Colorado State University for bicavitary effusion. On examination, the dog was tachycardic and tachypneic with bilaterally decreased lung sounds. Thoracic and abdominal ultrasonic examination revealed pleural and peritoneal effusions, which were aspirated and submitted for fluid analysis and cytology. Both cavity fluids were classified as exudates with a large population of vacuolated mononuclear cells...
September 2016: Veterinary Clinical Pathology
Mingyan Dai, Mingwei Bao, Yijie Zhang, Lilei Yu, Quan Cao, Yanhong Tang, He Huang, Xi Wang, Dan Hu, Congxin Huang
BACKGROUND: Low-level carotid baroreflex stimulation (LL-CBS) appears to have potential antiarrhythmogenic effect. OBJECTIVES: To investigate effects of short term LL-CBS on atrial fibrillation (AF) canine model. METHODS: Group 1: anesthetized dogs underwent 6 h of rapid atrial pacing (RAP) with concomitant LL-CBS in last three hours (LL-CBS group, n=7) or without (Control group, n=6). Effective refractory period (ERP), ERP dispersion, and window of vulnerability (WOV) to AF were determined...
August 9, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Amir Geramipour, Zsófia Kohajda, Claudia Corici, János Prorok, Zsolt Szakonyi, Kinga Oravecz, Zoltán Márton, Norbert Nagy, András Tóth, Károly Acsai, László Virág, András Varró, Norbert Jost
The sodium-calcium exchanger (NCX) is considered as the major transmembrane transport mechanism that controls Ca(2+) homeostasis. Its contribution to the cardiac repolarization has not yet been directly studied due to lack of specific inhibitors, so that an urgent need for more selective compounds. In this study, the electrophysiological effects of GYKB-6635, a novel NCX inhibitor, on the NCX, L-type calcium, and main repolarizing potassium currents as well as action potential (AP) parameters were investigated...
July 1, 2016: Canadian Journal of Physiology and Pharmacology
J M Gentile-Solomon, J A Abbott
INTRODUCTION: We sought to define reference intervals for echocardiographic dimensions of the canine right heart. Secondarily, we intended to describe measurement variability of these dimensions. ANIMALS: Forty-five healthy adult pet dogs of diverse somatotype. MATERIALS AND METHODS: To obtain normative data used to define reference intervals, dogs underwent one echocardiographic examination by the same operator. Raw data were subject to logarithmic (log10) transformation and allometric relationships between body weight and echocardiographic variables were determined; reference intervals intended to include 95% of the population were defined...
September 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
X Zhang, Y Zhang, F Gao, F Zhang, Z Yang, S Ouyang, M Rao, Y Hou
Atrial fibrillation (AF) is the most prevalent heart rhythm disorder, and autonomic nervous system (ANS) is important to AF. This study aims to identify whether changes in transmitters released by ANS could reflect their activities. The right atrium (RA) groups (1-40V) included RA500 and RA1000. While ANS groups received high-frequency electrical stimulation (1-8V, 20 Hz, 2 ms), including left stellate ganglion stimulation (LSGS) andleft cervical vagus trunk stimulation (LVTS). The induced rate of AF, duration and atrial effective refractory period (AERP) were measured...
2016: Cellular and Molecular Biology
A Zani, E Becchetti, T Chimenti, V Daddi, M Zani, C Miotti, C Bussadori
A 2-year-old recently spayed female Rottweiler was referred as an emergency with cardiac tamponade and the presence of an anomalous retrograde flow in the pulmonary artery. Echocardiography and angiography demonstrated a left-to-right aortopulmonary fistula. Clinical history and data indicated a possible infectious aetiology. Antibiotics and heart failure medications were administered for 30 days before intervention. Initial attempt at insertion of an Amplatz occluder by means of a percutaneous catheterization technique was tried but a safe release of the device was judged to be not possible due to the angle and the fragile and irregular margins of the window...
July 20, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
S Alonge, M Mauri, M Faustini, G C Luvoni
Few information is available on parameters that can be used to objectively assess the foetal health during canine pregnancy. To identify a reliable parameter for the evaluation of foetal well-being, the effect of pre-gestational maternal bodyweight and gestational age on foetal heart rate (FHR) and on feto-maternal heart rate ratio (FHR/MHR) was investigated. Seventeen client-owned pregnant bitches of different pre-gestational maternal bodyweight were examined by serial echo colour Doppler. Only data from 11 uncomplicated pregnancies were included in the statistical analysis...
October 2016: Reproduction in Domestic Animals, Zuchthygiene
Mingwei Tong, Li Yi, Yuening Cheng, Miao Zhang, Zhigang Cao, Jianke Wang, Hang Zhao, Peng Lin, Yong Yang, Shipeng Cheng
Toll-like receptors (TLRs) could recognize conserved molecular patterns and initiate a wide range of innate and adaptive immune responses against invading infectious agents. The aim of the this study is to assess the transcript profiling of mink TLRs (mTLRs) in mink peripheral blood mononuclear cells (PBMCs) and a range of tissues, and to explore the potential role of mTLRs in the antiviral immune response process. The results indicated that the mTLRs partial nucleotide sequences revealed a high degree of nucleotide identity with ferret sequences (95-98%)...
July 19, 2016: Journal of Microbiology and Biotechnology
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