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https://www.readbyqxmd.com/read/27933730/reactivity-of-9-aminoacridine-drug-quinacrine-with-glutathione-limits-its-anti-prion-activity
#1
Martin Šafařík, Tibor Moško, Zbigniew Zawada, Eva Šafaříková, Martin Dračínský, Karel Holada, Jaroslav Šebestík
Quinacrine - the drug based on 9-aminoacridine - failed in clinical trials for prion diseases, whereas it was active in in-vitro studies. We hypothesize that aromatic nucleophilic substitution at C9 could be contributing factor responsible for this failure because of the transfer of acridine moiety from quinacrine to abundant glutathione. Here, we described the semi-large-scale synthesis of the acridinylated glutathione and the consequences of its formation on biological and biophysical activities. The acridinylated glutathione is one order of magnitude weaker prion protein binder than the parent quinacrine...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933718/constipation-in-older-people-a-consensus-statement
#2
Anton Emmanuel, Francesco Mattace-Raso, Maria Cristina Neri, Karl-Uwe Petersen, Enrique Rey, June Rogers
BACKGROUND AND AIMS: Chronic constipation is a serious medical condition that affects 30%-40% of people over 60 years old. Although not normally life threatening, constipation reduces quality of life by the same extent as diabetes and osteoarthritis. There are currently no Europe-wide guidelines for treating constipation in older people, although there is some country-level guidance for the general population. We have evaluated the existing guidance and best clinical practice to improve the care of older people with constipation...
December 9, 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27933635/vietnamese-version-of-diabetes-self-management-instrument-development-and-psychometric-testing
#3
Tiet-Hanh Dao-Tran, Debra J Anderson, Anne M Chang, Charrlotte Seib, Cameron Hurst
Self-management plays a vital role in diabetes management for adults with type 2 diabetes (T2DM). While there are many people with T2DM in Vietnam, clinical understanding of diabetes self-management (DSM) in this context is limited due to the lack of a valid measurement instrument. Translation and back-translation processes were used to translate the Diabetes Self-Management Instrument (DSMI) into Vietnamese. Then, translation equivalence, face validity, construct validity, and internal consistency were assessed in a sample of 198 Vietnamese adults with T2DM...
December 9, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27933580/headache-service-quality-evaluation-of-quality-indicators-in-14-specialist-care-centres
#4
Sara Schramm, Derya Uluduz, Raquel Gil Gouveia, Rigmor Jensen, Aksel Siva, Ugur Uygunoglu, Giorgadze Gvantsa, Maka Mania, Mark Braschinsky, Elena Filatova, Nina Latysheva, Vera Osipova, Kirill Skorobogatykh, Julia Azimova, Andreas Straube, Ozan Emre Eren, Paolo Martelletti, Valerio De Angelis, Andrea Negro, Mattias Linde, Knut Hagen, Aleksandra Radojicic, Jasna Zidverc-Trajkovic, Ana Podgorac, Koen Paemeleire, Annelien De Pue, Christian Lampl, Timothy J Steiner, Zaza Katsarava
BACKGROUND: The study was a collaboration between Lifting The Burden (LTB) and the European Headache Federation (EHF). Its aim was to evaluate the implementation of quality indicators for headache care Europe-wide in specialist headache centres (level-3 according to the EHF/LTB standard). METHODS: Employing previously-developed instruments in 14 such centres, we made enquiries, in each, of health-care providers (doctors, nurses, psychologists, physiotherapists) and 50 patients, and analysed the medical records of 50 other patients...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27933569/decision-making-in-clinical-practice-oral-anticoagulant-therapy-in-patients-with-non-valvular-atrial-fibrillation-and-a-single-additional-stroke-risk-factor
#5
REVIEW
Tatjana S Potpara, Nikolaos Dagres, Nebojša Mujović, Dragan Vasić, Milika Ašanin, Milan Nedeljkovic, Francisco Marin, Laurent Fauchier, Carina Blomstrom-Lundqvist, Gregory Y H Lip
Approximately 1 in 3-4 patients presenting with an ischemic stroke will also have atrial fibrillation (AF), and AF-related strokes can be effectively prevented using oral anticoagulant therapy (OAC), either with well-controlled vitamin K antagonists (VKAs) or non-vitamin K antagonist oral anticoagulants (NOACs). In addition, OAC use (both VKAs and NOACs) is associated with a 26% reduction in all-cause mortality (VKAs) or an additional 10% mortality reduction with NOACs relative to VKAs. The decision to use OAC in individual AF patient is based on the estimated balance of the benefit from ischemic stroke reduction against the risk of major OAC-related bleeding [essentially intracranial hemorrhage (ICH)]...
December 8, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27933512/effect-of-chinese-medicine-treatment-based-on-pattern-identification-on-cellular-immunophenotype-of-myelodysplastic-syndrome
#6
Yu Zhang, Li-Li Qian, Jian-Ping Shen, Jun-Fa Chen, Yan-Ting Gao, Jing-Jing Xiang, Bao-Dong Ye, Yu-Hong Zhou
OBJECTIVE: To observe the influence of treatment based on Chinese medicine pattern identification on cellular immunophenotype of the myelodysplastic syndrome (MDS). METHODS: Sixty patients with MDS were randomly and equally assigned to the treatment group and the control group using a randomized digital table. Thirty patients in each group included 3 risk levels (low, moderate and high risks) with each level 10 patients according to the international prognostic scoring system...
December 9, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27933511/appraisal-of-the-quality-and-contents-of-clinical-practice-guidelines-for-hypertension-management-in-chinese-medicine-a-systematic-review
#7
REVIEW
Ya Yuwen, Xue-Jie Han, Wei-Liang Weng, Xue-Yao Zhao, Yu-Qi Liu, Wei-Qiang Li, Da-Sheng Liu, Yan-Ping Wang, Ai-Ping Lu
OBJECTIVE: To evaluate the quality and consistency of recommendations in the clinical practice guidelines (CPGs) for hypertension in Chinese medicine (CM). METHODS: CM CPGs were identified from 5 electronic databases and hand searches through related handbooks published from January 1990 to December 2013. Three reviewers independently appraised the CPGs based on the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument, and compared the CPGs' recommendations on CM syndrome pattern classification and treatment...
December 9, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27933508/patterns-of-diabetes-care-in-slovenia-croatia-serbia-bulgaria-and-romania-an-observational-non-interventional-cross-sectional-study
#8
Miro Cokolic, Nebojsa M Lalic, Dragan Micic, Gorana Mirosevic, Sanja Klobucar Majanovic, Ivaylo N Lefterov, Mariana Graur
BACKGROUND: National guidelines for treating type 2 diabetes in the Balkans generally follow European guidelines. The current study was undertaken to estimate the rate of glycated hemoglobin (HbA1c) measurements and level of HbA1c control in diabetic patients treated in regular clinical practice settings in the Balkans and to evaluate if providing HbA1c measurements improves adherence to treatment guidelines. METHODS: This cross-sectional study enrolled type 2 diabetic patients treated by 79 primary care physicians and 102 specialists...
December 8, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27933504/mental-health-support-provided-throughout-the-bariatric-surgery-clinical-pathway-in-french-specialized-care-centers-for-obesity
#9
Kristopher Lamore, Sandra S Kaci, Sébastien Czernichow, Marion Bretault, Jean-Luc Bouillot, Anne-Jeanne Naudé, Sandra Gribe-Ouaknine, Claire Carette, Cécile Flahault
OBJECTIVE: Pre-operative psychological assessment is recommended by international guidelines for bariatric surgery candidates. Thereby, service teams caring for bariatric patients should include at least one mental health provider (e.g., a psychologist or psychiatrist). The objective of this study was to evaluate the psychology and psychiatry resources and practices in the 37 specialized obesity centers (CSOs) created by the French Ministry of Health. MATERIALS AND METHODS: CSO coordinators were contacted by e-mail to collect general information on the centers (e...
December 8, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27933473/high-percentage-of-ibd-patients-with-indefinite-fecal-calprotectin-levels-additional-value-of-a-combination-score
#10
Alexander G L Bodelier, Daisy Jonkers, Tim van den Heuvel, Evelien de Boer, Wim Hameeteman, Ad A M Masclee, Marie J Pierik
BACKGROUND AND AIM: Monitoring mucosal inflammation in inflammatory bowel disease (IBD) is of major importance to prevent complications and improve long-term disease outcome. The correlation of clinical activity indices with endoscopic disease activity is, however, moderate. Fecal calprotectin (FC) is a better predictor of mucosal inflammation, but values between 100 and 250 µg/g are difficult to interpret in clinical practice. We aimed to evaluate the occurrence of indefinite FC levels in a real-life IBD cohort and study the additional value of a combination of biochemical markers and clinical activity indices...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933439/measurement-of-carotid-pulse-wave-velocity-using-ultrafast-ultrasound-imaging-in-hypertensive-patients
#11
Xiaopeng Li, Jue Jiang, Hong Zhang, Hua Wang, Donggang Han, Qi Zhou, Ya Gao, Shanshan Yu, Yanhua Qi
PURPOSE: The study aimed to assess the utility of ultrafast ultrasound imaging for evaluation of carotid pulse wave velocity (PWV) in newly diagnosed hypertension patients. METHODS: This prospective non-randomized study enrolled 90 hypertensive patients in our hospital from September to December 2013 as a hypertension group. An age- and sex-matched cohort of 50 healthy adults in our hospital from September to December 2013 was also included in the study as a control group...
December 8, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27933399/implementation-of-clinical-decision-support-in-young-children-with-acute-gastroenteritis-a-randomized-controlled-trial-at-the-emergency-department
#12
Dorien Geurts, Evelien de Vos-Kerkhof, Suzanne Polinder, Ewout Steyerberg, Johan van der Lei, Henriëtte Moll, Rianne Oostenbrink
: Acute gastroenteritis (AGE) is one of the most frequent reasons for young children to visit emergency departments (EDs). We aimed to evaluate (1) feasibility of a nurse-guided clinical decision support system for rehydration treatment in children with AGE and (2) the impact on diagnostics, treatment, and costs compared with usual care by attending physician. A randomized controlled trial was performed in 222 children, aged 1 month to 5 years at the ED of the Erasmus MC-Sophia Children's hospital in The Netherlands ( 2010-2012)...
December 8, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27933391/-tapering-and-termination-of-immunosuppressive-treatment-in-spondyloarthritides-including-psoriatic-arthritis
#13
REVIEW
G Scholz, B Möller
BACKGROUND: Immunomodulatory long-term treatment has also become the standard treatment for spondyloarthritides (SpA), including psoriatic arthritis (PsA); however, uncertainty exists about dose reduction or termination of treatment after remission or low disease activity. OBJECTIVE: When is it possible to reduce medication or terminate treatment for SpA? MATERIAL AND METHODS: An extensive non-systematic literature search was performed focusing on practice guidelines, systematic meta-analyses and clinical trials on medicinal long-term treatment and voluntary medication reduction in axial and peripheral SpA, including PsA...
December 8, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27933299/strategy-to-prime-the-host-and-cells-to-augment-therapeutic-efficacy-of-progenitor-cells-for-patients-with-myocardial-infarction
#14
REVIEW
Jeehoon Kang, Tae-Won Kim, Jin Hur, Hyo-Soo Kim
Cell therapy in myocardial infarction (MI) is an innovative strategy that is regarded as a rescue therapy to repair the damaged myocardium and to promote neovascularization for the ischemic border zone. Among several stem cell sources for this purpose, autologous progenitors from bone marrow or peripheral blood would be the most feasible and safest cell-source. Despite the theoretical benefit of cell therapy, this method is not widely adopted in the actual clinical practice due to its low therapeutic efficacy...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27933207/what-is-the-reliability-of-non-trained-investigators-in-recognising-structural-mri-lesions-of-sacroiliac-joints-in-patients-with-recent-inflammatory-back-pain-results-of-the-desir-cohort
#15
Charlotte Jacquemin, Roxana Rubio Vargas, Rosaline van den Berg, Fabrice Thévenin, Gregory Lenczner, Monique Reijnierse, Salah Ferkal, Philippe Le Corvoisier, Alain Rahmouni, Damien Loeuille, Antoine Feydy, Maxime Dougados, Désirée van der Heijde, Pascal Claudepierre
OBJECTIVE: The objective of this study was to evaluate the reliability of recognising structural lesions on MRI (erosions, fatty lesions, ankylosis) of the sacroiliac joints (MRI-SIJ) in clinical practice compared to a central reading in patients with a possible recent axial spondyloarthritis (axSpA). METHODS: Patients aged 18-50 years, with recent (<3 years) and chronic (≥3 months) inflammatory back pain, suggestive of axSpA were included in the DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR) cohort...
2016: RMD Open
https://www.readbyqxmd.com/read/27933151/improving-asthma-care-in-a-pediatric-resident-clinic
#16
Julia Lee, Albina Gogo, Daniel Tancredi, Erik Fernandez Y Garcia, Ulfat Shaikh
There is variation in pediatric asthma management in the outpatient setting. Adherence to national asthma guidelines provides a systematic standardized approach to asthma management. There is a gap between usual and guideline-consistent asthma care in resident clinics. Practice improvement modules aimed at improving resident physician adherence to asthma care guidelines have not been consistently utilized and have not yet been studied. Our aim was to increase guideline consistent care in our pediatric resident clinic in a twelve-month period via increasing performance on the following measures to 75%: spirometry testing; influenza immunization recommendation; level of control assessed through the use of a standardized questionnaire; appropriate medications per national guideline; and use of written asthma action plans...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27933105/prevalence-of-atrial-fibrillation-in-the-malaysian-communities
#17
Chiao Wen Lim, Sazzli Kasim, Johan Rizwal Ismail, Nicholas Yul Chye Chua, Rizmy Najme Khir, Hafisyatul Aiza Zainal Abidin, Effarezan Abdul Rahman, Mohd Kamal Mohd Arshad, Zubin Ibrahim Othman, Khalid Yusoff
BACKGROUND AND AIM: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. The REDISCOVER (Responding to Increasing Cardiovascular disease prevalence) study is an observational longitudinal community-based study that tracks changing lifestyles, risk factors and chronic disease in urban and rural areas of Malaysia. In this study, we aim to study the prevalence of AF and its associated risk factors. METHODS: The study was conducted between 2007 and 2014...
2016: Heart Asia
https://www.readbyqxmd.com/read/27932895/are-patients-and-doctors-accounts-of-the-first-specialist-consultation-for-chronic-back-pain-in-agreement
#18
Kathy B White, John Lee, Amanda C de C Williams
INTRODUCTION: The first consultation at a specialist pain clinic is potentially a pivotal event in a patient's pain history, affecting treatment adherence and engagement with longer term self-management. What doctors communicate to patients about their chronic pain and how patients interpret doctors' messages and explanations in pain consultations are under-investigated, particularly in specialist care. Yet, patients value personalized information about their pain problem. PATIENTS AND METHODS: Sixteen patients in their first specialist pain clinic consultation and the doctors they consulted were interviewed shortly after the consultation...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27932873/coherence-between-self-reported-and-objectively-measured-physical-activity-in-patients-with-chronic-obstructive-lung-disease-a-systematic-review
#19
REVIEW
Mimi Thyregod, Uffe Bodtger
The beneficial effects of physical activity (PA) in patients with COPD, as well as the methods of their assessment, are well known and described. As objective measures of PA, such as the use of motion sensors, video recordings, exercise capacity testing, and indirect calorimetry, are not easily obtained in the daily clinical life, the reliability of the more accessible self-reported measurements of PA is important. In this review, we systematically identified original studies involving COPD patients and at least one parameter of self-reported and objective exercise testing, and analyzed every article for coherence between the objectively and self-reported measured PA...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27932844/what-factors-influence-patient-compliance-with-supportive-periodontal-therapy-in-a-general-practice-setting
#20
C Perrell-Jones, R S Ireland
Background The importance of supportive periodontal therapy following active treatment has been well documented but numerous studies have shown patient compliance to be poor. The aim of this study was to ascertain which factors affect patient compliance and whether this included routinely recorded periodontal indices.Methodology This was a five-year retrospective service evaluation study set within a private general dental practice. It utilised demographic and periodontal data from patients who attended the practice for chronic periodontal treatment in 2009 and ascertained whether there were links between this data and compliance with the supportive phase of periodontal treatment...
December 9, 2016: British Dental Journal
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