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https://www.readbyqxmd.com/read/29146643/are-il18rap-gene-polymorphisms-associated-with-body-mass-regulation-a-cross-sectional-study
#1
Vanesa Martínez-Barquero, Griselda de Marco, Sergio Martínez-Hervas, Victoria Adam-Felici, Cristina Pérez-Soriano, Verónica Gonzalez-Albert, Gemma Rojo, Juan Francisco Ascaso, José Tomás Real, Ana Barbara Garcia-Garcia, Juan Carlos Martín-Escudero, Raquel Cortes, Felipe Javier Chaves
OBJECTIVES: To investigate the association between IL18RAP and body mass index (BMI) and obesity and to verify the effect of a polymorphism in the microRNA136 (MIR136) IL18RAP binding region. DESIGN: We analysed samples from two Spanish cross-sectional studies, VALCAR (Spanish Mediterranean coast) and Hortega (Spanish centre). These studies aimed at analysing cardiovascular risk and development of cardiovascular disease in the general population. Both populations correspond to regions with different characteristics...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29144439/cell-line-secretome-and-tumor-tissue-proteome-markers-for-early-detection-of-colorectal-cancer-a-systematic-review
#2
REVIEW
Megha Bhardwaj, Vanessa Erben, Petra Schrotz-King, Hermann Brenner
Objective: In order to find low abundant proteins secretome and tumor tissue proteome data have been explored in the last few years for the diagnosis of colorectal cancer (CRC). In this review we aim to summarize the results of studies evaluating markers derived from the secretome and tumor proteome for blood based detection of colorectal cancer. Methods: Observing the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines PubMed and Web of Science databases were searched systematically for relevant studies published up to 18 July 2017...
November 16, 2017: Cancers
https://www.readbyqxmd.com/read/29143616/diagnostic-accuracy-of-detection-and-quantification-of-hbv-dna-and-hcv-rna-using-dried-blood-spot-dbs-samples-a-systematic-review-and-meta-analysis
#3
Berit Lange, Teri Roberts, Jennifer Cohn, Jamie Greenman, Johannes Camp, Azumi Ishizaki, Luke Messac, Edouard Tuaillon, Philippe van de Perre, Christine Pichler, Claudia M Denkinger, Philippa Easterbrook
BACKGROUND: The detection and quantification of hepatitis B (HBV) DNA and hepatitis C (HCV) RNA in whole blood collected on dried blood spots (DBS) may facilitate access to diagnosis and treatment of HBV and HCV infection in resource-poor settings. We evaluated the diagnostic performance of DBS compared to venous blood samples for detection and quantification of HBV-DNA and HCV-RNA in two systematic reviews and meta-analyses on the diagnostic accuracy of HBV DNA and HCV RNA from DBS compared to venous blood samples...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29141808/what-should-a-person-with-relapsing-remitting-multiple-sclerosis-know-focus-group-and-survey-data-of-a-risk-knowledge-questionnaire-rikno-2-0
#4
C Heesen, J Pöttgen, A C Rahn, K Liethmann, J Kasper, L Vahter, J Drulovic, A Van Nunen, D Wilkie, Y Beckmann, F Paul, S Köpke, A Giordano, A Solari
BACKGROUND: Risk knowledge is relevant to make informed decisions in multiple sclerosis (MS). The risk knowledge questionnaire for relapsing-remitting MS (RIKNO 1.0) was developed and piloted in Germany. OBJECTIVE: To produce a revised RIKNO 2.0 questionnaire using mixed methodology in a European setting. METHODS: The questionnaire was translated in seven languages. MS patient and health professional (HP) expert feedback was obtained from Germany, Italy, Estonia, Serbia, and the UK...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29138506/diagnostic-performance-of-susceptibility-weighted-magnetic-resonance-imaging-for-the-detection-of-calcifications-a-systematic-review-and-meta-analysis
#5
Lisa C Adams, Keno Bressem, Sarah Maria Böker, Yi-Na Yvonne Bender, Dominik Nörenberg, Bernd Hamm, Marcus R Makowski
Since its introduction, susceptibility-weighted-magnetic resonance imaging (SW-MRI) has shown the potential to overcome the insensitivity of MRI to calcification. Previous studies reporting the diagnostic performance of SW-MRI and magnetic resonance imaging (MRI) for the detection of calcifications are inconsistent and based on single-institution designs. To our knowledge, this is the first meta-analysis on SW-MRI, determining the potential of SW-MRI to detect calcifications. Two independent investigators searched MEDLINE, EMBASE and Web of Science for eligible diagnostic accuracy studies, which were published until March 24, 2017 and investigated the accuracy of SW-MRI to detect calcifications, using computed tomography (CT) as a reference...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130235/-a-meta-analysis-on-risk-factors-of-postoperative-perineal-wound-complications-after-abdominoperineal-resection-for-rectal-cancer
#6
Senqi Lu, Xiaofeng Chang, Xiaodong Yang, Decai Yu, Qigen Huang, Feng Wang
OBJECTIVE: To investigate the risk factors of postoperative perineal wound complications after abdominoperineal resection for rectal cancer. METHODS: The databases of Medline, Embase, Web of Science, Ovid, Cochrane Library, CBM, CNKI, VIP and WANFANG were searched for the studies of abdominoperineal resection up to October 2016. The quality of the included studies was assessed by using "Cochrane collaboration's tool for assessing risk of bias" and "the Newcastle-Ottawa Scale"...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29127948/association-of-high-sensitivity-cardiac-troponin-i-concentration-with-cardiac-outcomes-in-patients-with-suspected-acute-coronary-syndrome
#7
Andrew R Chapman, Kuan Ken Lee, David A McAllister, Louise Cullen, Jaimi H Greenslade, William Parsonage, Andrew Worster, Peter A Kavsak, Stefan Blankenberg, Johannes Neumann, Nils A Söerensen, Dirk Westermann, Madelon M Buijs, Gerard J E Verdel, John W Pickering, Martin P Than, Raphael Twerenbold, Patrick Badertscher, Zaid Sabti, Christian Mueller, Atul Anand, Philip Adamson, Fiona E Strachan, Amy Ferry, Dennis Sandeman, Alasdair Gray, Richard Body, Brian Keevil, Edward Carlton, Kim Greaves, Frederick K Korley, Thomas S Metkus, Yader Sandoval, Fred S Apple, David E Newby, Anoop S V Shah, Nicholas L Mills
Importance: High-sensitivity cardiac troponin I testing is widely used to evaluate patients with suspected acute coronary syndrome. A cardiac troponin concentration of less than 5 ng/L identifies patients at presentation as low risk, but the optimal threshold is uncertain. Objective: To evaluate the performance of a cardiac troponin I threshold of 5 ng/L at presentation as a risk stratification tool in patients with suspected acute coronary syndrome. Data Sources: Systematic search of MEDLINE, EMBASE, Cochrane, and Web of Science databases from January 1, 2006, to March 18, 2017...
November 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29126216/pager-2-0-an-update-to-the-pathway-annotated-list-and-gene-signature-electronic-repository-for-human-network-biology
#8
Zongliang Yue, Qi Zheng, Michael T Neylon, Minjae Yoo, Jimin Shin, Zhiying Zhao, Aik Choon Tan, Jake Y Chen
Integrative Gene-set, Network and Pathway Analysis (GNPA) is a powerful data analysis approach developed to help interpret high-throughput omics data. In PAGER 1.0, we demonstrated that researchers can gain unbiased and reproducible biological insights with the introduction of PAGs (Pathways, Annotated-lists and Gene-signatures) as the basic data representation elements. In PAGER 2.0, we improve the utility of integrative GNPA by significantly expanding the coverage of PAGs and PAG-to-PAG relationships in the database, defining a new metric to quantify PAG data qualities, and developing new software features to simplify online integrative GNPA...
November 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29125628/genomics-based-non-invasive-prenatal-testing-for-detection-of-fetal-chromosomal-aneuploidy-in-pregnant-women
#9
REVIEW
Mylène Badeau, Carmen Lindsay, Jonatan Blais, Leon Nshimyumukiza, Yemisi Takwoingi, Sylvie Langlois, France Légaré, Yves Giguère, Alexis F Turgeon, William Witteman, François Rousseau
BACKGROUND: Common fetal aneuploidies include Down syndrome (trisomy 21 or T21), Edward syndrome (trisomy 18 or T18), Patau syndrome (trisomy 13 or T13), Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX) and 47,XYY syndrome (47,XYY). Prenatal screening for fetal aneuploidies is standard care in many countries, but current biochemical and ultrasound tests have high false negative and false positive rates. The discovery of fetal circulating cell-free DNA (ccfDNA) in maternal blood offers the potential for genomics-based non-invasive prenatal testing (gNIPT) as a more accurate screening method...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29122267/effects-of-traditional-chinese-exercises-on-the-rehabilitation-of-limb-function-among-stroke-patients-a-systematic-review-and-meta-analysis
#10
REVIEW
Li Ge, Qing-Xiang Zheng, Yan-Tan Liao, Jing-Yu Tan, Qiu-Lin Xie, Mikael Rask
OBJECTIVE: To systematically review literature about the rehabilitative effects of traditional Chinese exercises (TCEs) on limb function among patients with stroke. METHODS: Systematic review and meta-analysis of randomized controlled trials (RCTs). Twelve electronic databases were searched from their inceptions to February 2017, including PudMed, The Cochrane Library, Web of Science, EMBase, Science Direct, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine, Chinese Scientific Journal Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database and WanFang Data...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29117929/a-fully-automated-web-based-program-improves-lifestyle-habits-and-hba1c-in-patients-with-type-2-diabetes-and-abdominal-obesity-randomized-trial-of-patient-e-coaching-nutritional-support-the-anode-study
#11
Boris Hansel, Philippe Giral, Laetitia Gambotti, Alexandre Lafourcade, Gilbert Peres, Claude Filipecki, Diana Kadouch, Agnes Hartemann, Jean-Michel Oppert, Eric Bruckert, Michel Marre, Arnaud Bruneel, Emilie Duchene, Ronan Roussel
BACKGROUND: The prevalence of abdominal obesity and type 2 diabetes mellitus (T2DM) is a public health challenge. New solutions need to be developed to help patients implement lifestyle changes. OBJECTIVE: The objective of the study was to evaluate a fully automated Web-based intervention designed to help users improve their dietary habits and increase their physical activity. METHODS: The Accompagnement Nutritionnel de l'Obésité et du Diabète par E-coaching (ANODE) study was a 16-week, 1:1 parallel-arm, open-label randomized clinical trial...
November 8, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29114694/the-impact-of-clinical-pharmacists-in-improving-jordanian-patients-health-outcomes
#12
Eman A Hammad, Rajaa A Qudah, Amal A Akour
To assess the impacts of clinical pharmacists on Jordanian patients' health outcomes. Methods: A systematic review was conducted until July 2016 within EBSCO, Pubmed, Cochrane database, and ISI Web of Knowledge. Published studies evaluating the benefit of clinical pharmacy services on therapeutic, safety, humanistic, and economic outcomes in hospital or community settings in Jordan were targeted. Two reviewers independently extracted and assessed risk of bias using a pre-published validated tool. The literature search identified 130 publications of which 21 full texts met predetermined inclusion criteria...
November 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29114435/hepatitis-c-virus-genie-a-web-2-0-interpretation-and-analytics-platform-for-the-versant-hepatitis-c-virus-genotype-line-probe-assay-version-2-0
#13
Alex M Dussaq, Abha Soni, Christopher Willey, Seung L Park, Shuko Harada
Context: Hepatitis C virus (HCV) genotyping at our institution is performed using the Versant HCV genotype 2.0 Line Probe Assay (LiPA). The last steps of this procedure are manual, laborious, and error-prone process that involves the comparison of the banding pattern on a test strip to a physical reference table. Aim: We developed a web-based HCV genotype interpretation platform that utilizes a scanned image to generate the genotypes, thus minimizing interpretation time and reducing error...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29107943/comparison-of-diagnostic-accuracy-of-magnetic-resonance-elastography-and-fibroscan-for-detecting-liver-fibrosis-in-chronic-hepatitis-b-patients-a-systematic-review-and-meta-analysis
#14
Huanming Xiao, Meijie Shi, Yubao Xie, Xiaoling Chi
AIM: This systematic review and meta-analysis was carried out to compare the diagnostic accuracy of Magnetic resonance elastography (MRE) and Fibroscan for detecting liver fibrosis in Chronic Hepatitis B (CHB) patients. METHODS: The PubMed, the Cochrane Library, and the Web of science databases were searched for studies that evaluated the diagnostic value of MRE and Fibroscan for liver fibrosis in CHB patients until March 1st 2017. The quality of the included studies was assessed by the revised Quality Assessment for Studies of Diagnostic Accuracy tool (QUADAS-2)...
2017: PloS One
https://www.readbyqxmd.com/read/29100533/effectiveness-of-interventions-during-nicu-hospitalization-on-the-neurodevelopment-of-preterm-infants-a-systematic-review-protocol
#15
Marilyn Aita, Robyn Stremler, Nancy Feeley, Andréane Lavallée, Gwenaëlle De Clifford-Faugère
BACKGROUND: Previous systematic reviews have examined preterm infants' long-term neurodevelopment after neonatal intensive care unit (NICU) discharge, although none have explored the effectiveness of interventions on preterm infants' neurodevelopment during NICU hospitalization. The aim of this review is to evaluate whether interventions, i.e., sensory stimulation, parental involvement, and control of environment, improve preterm infants' neurodevelopment during their NICU hospitalization...
November 3, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29082015/does-foreign-aid-crowd-out-government-investments-evidence-from-rural-health-centres-in-rwanda
#16
Chunling Lu, Benjamin Cook, Chris Desmond
BACKGROUND: Rural healthcare facilities in low-income countries play a major role in providing primary care to rural populations. We examined the link of foreign aid with government investments and medical service provision in rural health centres in Rwanda. METHODS: Using the District Health System Strengthening Tool, a web-based database built by the Ministry of Health in Rwanda, we constructed two composite indices representing provision of (1) child and maternal care and (2) HIV, tuberculosis (TB) and malaria services in 330 rural health centres between 2009 and 2011...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29073916/participant-recruitment-and-retention-in-longitudinal-preconception-randomized-trials-lessons-learnt-from-the-calcium-and-pre-eclampsia-cap-trial
#17
Theresa A Lawrie, Ana Pilar Betrán, Mandisa Singata-Madliki, Alvaro Ciganda, G Justus Hofmeyr, José M Belizán, Tina Dannemann Purnat, Sarah Manyame, Catherine Parker, Gabriela Cormick
BACKGROUND: The preconception period has the potential to influence pregnancy outcomes and randomized controlled trials (RCTs) are needed to evaluate a variety of potentially beneficial preconception interventions. However, RCTs commencing before pregnancy have significant participant recruitment and retention challenges. The Calcium And Pre-eclampsia trial (CAP trial) is a World Health Organization multi-country RCT of calcium supplementation commenced before pregnancy to prevent recurrent pre-eclampsia in which non-pregnant participants are recruited and followed up until childbirth...
October 26, 2017: Trials
https://www.readbyqxmd.com/read/29061467/an-interactive-simulation-tool-for-patient-specific-clinical-decision-support-in-single-ventricle-physiology
#18
Timothy Conover, Anthony M Hlavacek, Francesco Migliavacca, Ethan Kung, Adam Dorfman, Richard S Figliola, Tain-Yen Hsia
OBJECTIVE: Modeling of single-ventricle circulations has yielded important insights into their unique flow dynamics and physiology. Here we translated a state-of-the-art mathematical model into a patient-specific clinical decision support interactive Web-based simulation tool and show validation for all 3 stages of single-ventricular palliation. METHODS: Via the adoption a validated lumped parameter method, complete cardiovascular-pulmonary circulatory models of all 3 stages of single-ventricle physiology were created within a simulation tool...
September 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29054676/is-diagnostic-performance-of-quantitative-2d-shear-wave-elastography-optimal-for-clinical-classification-of-benign-and-malignant-thyroid-nodules-a-systematic-review-and-meta-analysis
#19
Haliimah A Nattabi, Norhafidzah M Sharif, Noorazrul Yahya, Rozilawati Ahmad, Mazlyfarina Mohamad, Faizah M Zaki, Ahmad N Yusoff
RATIONALE AND OBJECTIVE: This study is a dedicated 2D-shear wave elastography (2D-SWE) review aimed at systematically eliciting up-to-date evidence of its clinical value in differential diagnosis of benign and malignant thyroid nodules. METHODS: PubMed, Web of Science, and Scopus databases were searched for studies assessing the diagnostic value of 2D-SWE for thyroid malignancy risk stratification published until December 2016. The retrieved titles and abstracts were screened and evaluated according to the predefined inclusion and exclusion criteria...
October 17, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29036527/isyte-2-0-a-database-for-expression-based-gene-discovery-in-the-eye
#20
Atul Kakrana, Andrian Yang, Deepti Anand, Djordje Djordjevic, Deepti Ramachandruni, Abhyudai Singh, Hongzhan Huang, Joshua W K Ho, Salil A Lachke
Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited to visualization by only UCSC-Genome Browser tracks. To increase its efficacy, here we provide an enhanced iSyTE version 2.0 (URL: http://research.bioinformatics.udel.edu/iSyTE) based on well-curated, comprehensive genome-level lens expression data as a one-stop portal for the effective visualization and analysis of candidate genes in lens development and disease...
September 19, 2017: Nucleic Acids Research
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