Priyanka Saha, Subhrajita Panda, Aayusha Holkar, Rahul Vashishth, Sandeep Singh Rana, Mohana Priya Arumugam, Ghulam Md Ashraf, Shafiul Haque, Faraz Ahmad
Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely linked to the pathogeneses of several brain disorders. Importantly, exogenous agmatine has been shown to act as a potent neuroprotectant in varied pathologies, including brain ageing and associated comorbidities. The antioxidant, anxiolytic, analgesic, antidepressant and memory-enhancing activities of agmatine may derive from its ability to regulate several cellular pathways; including cell metabolism, survival and differentiation, nitric oxide signalling, protein translation, oxidative homeostasis and neurotransmitter signalling...
September 4, 2023: Ageing Research Reviews