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Agmatine

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https://www.readbyqxmd.com/read/28442607/n-methyl-d-aspartate-nmda-receptor-blockade-prevents-neuronal-death-induced-by-zika-virus-infection
#1
Vivian V Costa, Juliana L Del Sarto, Rebeca F Rocha, Flavia R Silva, Juliana G Doria, Isabella G Olmo, Rafael E Marques, Celso M Queiroz-Junior, Giselle Foureaux, Julia Maria S Araújo, Allysson Cramer, Ana Luíza C V Real, Lucas S Ribeiro, Silvia I Sardi, Anderson J Ferreira, Fabiana S Machado, Antônio C de Oliveira, Antônio L Teixeira, Helder I Nakaya, Danielle G Souza, Fabiola M Ribeiro, Mauro M Teixeira
Zika virus (ZIKV) infection is a global health emergency that causes significant neurodegeneration. Neurodegenerative processes may be exacerbated by N-methyl-d-aspartate receptor (NMDAR)-dependent neuronal excitoxicity. Here, we have exploited the hypothesis that ZIKV-induced neurodegeneration can be rescued by blocking NMDA overstimulation with memantine. Our results show that ZIKV actively replicates in primary neurons and that virus replication is directly associated with massive neuronal cell death. Interestingly, treatment with memantine or other NMDAR blockers, including dizocilpine (MK-801), agmatine sulfate, or ifenprodil, prevents neuronal death without interfering with the ability of ZIKV to replicate in these cells...
April 25, 2017: MBio
https://www.readbyqxmd.com/read/28358844/olfactory-effects-of-a-hypervariable-multicomponent-pheromone-in-the-red-legged-salamander-plethodon-shermani
#2
Damien B Wilburn, Kari A Doty, Adam J Chouinard, Sarah L Eddy, Sarah K Woodley, Lynne D Houck, Richard C Feldhoff
Chemical communication via chemosensory signaling is an essential process for promoting and modifying reproductive behavior in many species. During courtship in plethodontid salamanders, males deliver a mixture of non-volatile proteinaceous pheromones that activate chemosensory neurons in the vomeronasal epithelium (VNE) and increase female receptivity. One component of this mixture, Plethodontid Modulating Factor (PMF), is a hypervariable pheromone expressed as more than 30 unique isoforms that differ between individual males-likely driven by co-evolution with female receptors to promote gene duplication and positive selection of the PMF gene complex...
2017: PloS One
https://www.readbyqxmd.com/read/28315344/further-analysis-of-the-inhibition-by-agmatine-on-the-cardiac-sympathetic-outflow-role-of-the-%C3%AE-2-adrenoceptor-subtypes
#3
Luis Cobos-Puc, Hilda Aguayo-Morales, Janeth Ventura-Sobrevilla, Diana Luque-Contreras, Miguel Chin-Chan
This study has investigated the role of the α2-adrenoceptor subtypes involved in the inhibition of the cardiac sympathetic outflow induced by intravenous (i.v) infusions of agmatine. Therefore, we analysed the effect of an i.v. bolus injections of the selective antagonists BRL 44408 (300μg/kg; α2A), imiloxan (3000μg/kg; α2B), and JP-1302 (300μg/kg; α2C) given separately, and their combinations: BRL 44408 plus Imiloxan, JP 1302 plus imiloxan, BRL 44408 plus JP-1302, BRL 44408 plus imiloxan plus JP-1302 on the cardiac sympatho-inhibition of agmatine...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28302445/agmatine-attenuates-chronic-unpredictable-mild-stress-induced-anxiety-depression-like-behaviours-and-cognitive-impairment-by-modulating-nitrergic-signalling-pathway
#4
Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juvekar
Agmatine, a neurotransmitter/neuromodulator, has shown to exert numerous effects on the CNS. Chronic stress is a risk factor for development of depression, anxiety and deterioration of cognitive performance. Compelling evidences indicate an involvement of nitric oxide (NO) pathway in these disorders. Hence, investigation of the beneficial effects of agmatine on chronic unpredictable mild stress (CUMS)-induced depression, anxiety and cognitive performance with the involvement of nitrergic pathway was undertaken...
March 13, 2017: Brain Research
https://www.readbyqxmd.com/read/28238850/further-studies-of-the-effects-of-aging-on-arginine-metabolites-in-the-rat-vestibular-nucleus-and-cerebellum
#5
P Liu, N Gupta, Y Jing, N D Collie, H Zhang, P F Smith
Some studies have demonstrated that aging is associated with impaired vestibular reflexes, especially otolithic reflexes, resulting in postural instability. However, the neurochemical basis of these age-related changes is still poorly understood. The l-arginine metabolic system has been implicated in changes in the brain associated with aging. In the current study, we examined the levels of l-arginine and its metabolizing enzymes and downstream metabolites in the vestibular nucleus complex (VNC) and cerebellum (CE) of rats with and without behavioral testing which were young (4months old), middle-aged (12months old) or aged (24months old)...
February 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28213886/dysregulation-of-metabolic-pathways-in-a-mouse-model-of-allergic-asthma
#6
K D Quinn, M Schedel, Y Nkrumah-Elie, A Joetham, M Armstrong, C Cruickshank-Quinn, R Reisdorph, E W Gelfand, N Reisdorph
BACKGROUND: Asthma is a complex lung disease resulting from the interplay of genetic and environmental factors. To understand the molecular changes that occur during the development of allergic asthma without genetic and environmental confounders, an experimental model of allergic asthma in mice was used. Our goals were to (1) identify changes at the small molecule level due to allergen exposure, (2) determine perturbed pathways due to disease, and (3) determine whether small molecule changes correlate with lung function...
February 18, 2017: Allergy
https://www.readbyqxmd.com/read/28178624/agmatine-enhances-the-antidepressant-like-effect-of-lithium-in-mouse-forced-swimming-test-through-nmda-pathway
#7
Gholmreza Mohseni, Sattar Ostadhadi, Muhammad Imran-Khan, Abbas Norouzi-Javidan, Samira Zolfaghari, Nazgol-Sadat Haddadi, Ahmad-Reza Dehpour
Depression is one the world leading global burdens leading to various comorbidities. Lithium as a mainstay in the treatment of depression is still considered gold standard treatment. Similar to lithium another agent agmatine has also central protective role against depression. Since, both agmatine and lithium modulate various effects through interaction with NMDA receptor, therefore, in current study we aimed to investigate the synergistic antidepressant-like effect of agmatine with lithium in mouse force swimming test...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28131838/phospholipase-c-dependent-hydrolysis-of-phosphatidylinositol-4-5-bisphosphate-underlies-agmatine-induced-suppression-of-n-type-ca-2-channel-in-rat-celiac-ganglion-neurons
#8
Young-Hwan Kim, Ji-Hyun Jeong, Duck-Sun Ahn, Seungsoo Chung
Agmatine suppresses peripheral sympathetic tone by modulating Cav2.2 channels in peripheral sympathetic neurons. However, the detailed cellular signaling mechanism underlying the agmatine-induced Cav2.2 inhibition remains unclear. Therefore, in the present study, we investigated the electrophysiological mechanism for the agmatine-induced inhibition of Cav2.2 current (ICav2.2) in rat celiac ganglion (CG) neurons. Consistent with previous reports, agmatine inhibited ICav2.2 in a VI manner. The agmatine-induced inhibition of the ICav2...
January 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28122652/effects-of-agmatine-sulphate-on-facial-nerve-injuries
#9
O Surmelioglu, L Sencar, S Ozdemir, O Tarkan, M Dagkiran, N Surmelioglu, U Tuncer, S Polat
OBJECTIVE: To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy. METHODS: The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination...
March 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28109885/hetero-and-homodimerization-of-arabidopsis-thaliana-arginine-decarboxylase-atadc1-and-atadc2
#10
Israel Maruri-López, Juan F Jiménez-Bremont
The arginine decarboxylase enzyme (ADC) carries out the production of agmatine from arginine, which is the precursor of the first polyamine (PA) known as putrescine; subsequently, putrescine is turned into the higher PAs, spermidine and spermine. In Arabidopsis thaliana PA production occurs only from arginine and this step is initiated by two ADC paralogues, AtADC1 and AtADC2. PA production is essential for A. thaliana life cycle. Here, we analyzed the sub-cellular localization of AtADC1 and AtADC2 enzymes through GFP translational fusions...
March 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28006753/agmatine-ameliorates-adjuvant-induced-arthritis-and-inflammatory-cachexia-in-rats
#11
Brijesh G Taksande, Dinesh Y Gawande, Chandrabhan T Chopde, Milind J Umekar, Nandkishor R Kotagale
The present study investigated the pharmacological effect of agmatine in Complete Freud Adjuvant (CFA) induced arthritis and cachexia in rats. The rats were injected with CFA (0.1ml/rat) to induced symptoms of arthritis. Day 8 onwards of CFA administration, rats were injected daily with agmatine for next 7days, and arthritis score, body weights and food intake were monitored daily (g). Since cachexia is known to produce severe inflammation, malnutrition and inhibition of albumin gene expression, we have also monitored the total proteins, albumin, TNF-α and IL-6 levels in arthritic rats and its modulation by agmatine...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27994462/novel-guanidinylated-bioresponsive-poly-amidoamine-s-designed-for-short-hairpin-rna-delivery
#12
Jiankun Yu, Jinmin Zhang, Haonan Xing, Yanping Sun, Zhen Yang, Tianzhi Yang, Cuifang Cai, Xiaoyun Zhao, Li Yang, Pingtian Ding
Two different disulfide (SS)-containing poly(amidoamine) (PAA) polymers were constructed using guanidino (Gua)-containing monomers (ie, arginine [Arg] and agmatine [Agm]) and N,N'-cystamine bisacrylamide (CBA) by Michael-addition polymerization. In order to characterize these two Gua-SS-PAA polymers and investigate their potentials as short hairpin RNA (shRNA)-delivery carriers, pSilencer 4.1-CMV FANCF shRNA was chosen as a model plasmid DNA to form complexes with these two polymers. The Gua-SS-PAAs and plasmid DNA complexes were determined with particle sizes less than 90 nm and positive ζ-potentials under 20 mV at nucleic acid:polymer weight ratios lower than 1:24...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27993640/protective-effects-of-agmatine-on-doxorubicin-induced-chronic-cardiotoxicity-in-rat
#13
Fatemeh Yarmohmmadi, Nastaran Rahimi, Hedyeh Faghir-Ghanesefat, Nina Javadian, Alireza Abdollahi, Parvin Pasalar, Farahnaz Jazayeri, Shahram Ejtemaeemehr, Ahmad Reza Dehpour
The detrimental cardio-toxic effect of doxorubicin, an effective chemotherapeutic agent, limited its clinical use. It has been claimed that doxorubicin cardio-toxicity occurs through calcium ions (Ca(2+)) overload and reactive oxygen species production. Agmatine, an endogenous imidazoline receptor agonist, induce uptake of cytosolic Ca(2+) and cause an increase in activity of calcium pumps, including Ca(2+)-ATPase. Also it shows self-scavenging effect against reactive oxygen species production. Therefore, present study was designed to investigate the effects of agmatine against chronic cardio-toxicity of doxorubicin in rats...
December 16, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27988355/agmatine-modulates-melanogenesis-via-mitf-signaling-pathway
#14
Eun-Jeong Kwon, Moon-Moo Kim
Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition to the effect of agmatine on mushroom tyrosinase in vitro in the presence of different concentrations of agmatine...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27934648/arginine-metabolism-revisited
#15
REVIEW
Sidney M Morris
Mammalian arginine metabolism is complex due to the expression of multiple enzymes that utilize arginine as substrate and to interactions or competition between specific enzymes involved in arginine metabolism. Moreover, cells may contain multiple intracellular arginine pools that are not equally accessible to all arginine metabolic enzymes, thus presenting additional challenges to more fully understanding arginine metabolism. At the whole-body level, arginine metabolism ultimately results in the production of a biochemically diverse range of products, including nitric oxide, urea, creatine, polyamines, proline, glutamate, agmatine, and homoarginine...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27899287/pre-treatment-with-vinpocetine-protects-against-retinal-ischemia
#16
Lisa Nivison-Smith, Pauline Khoo, Monica L Acosta, Michael Kalloniatis
Vinpocetine has been shown to have beneficial effects for tissues of the central nervous system subjected to ischemia and other related metabolic insults. We recently showed vinpocetine promotes glucose availability, prevents unregulated cation channel permeability and regulates glial reactivity when present during retinal ischemia. Less is known however about the ability of vinpocetine to protect against future ischemic insults. This study explores the effect of vinpocetine when used as a pre-treatment in an ex vivo model for retinal ischemia using cation channel permeability of agmatine (AGB) combined with immunohistochemistry as a measure for cell functionality...
November 27, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27873165/analysing-the-effect-of-i1-imidazoline-receptor-ligands-on-dss-induced-acute-colitis-in-mice
#17
Ágnes Fehér, Viktória E Tóth, Mahmoud Al-Khrasani, Mihály Balogh, Bernadette Lázár, Zsuzsanna Helyes, Klára Gyires, Zoltán S Zádori
Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases; and moxonidine and rilmenidine, agonists of I1-IRs, are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or other molecular targets, which could be beneficial in patients with inflammatory bowel disease (IBD). On the other hand, several IR ligands may stimulate also alpha2-adrenoceptors, which were earlier shown to inhibit, but in more recent studies to rather aggravate colitis...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27846445/mammalian-agmatinases-constitute-unusual-members-in-the-family-of-mn-2-dependent-ureahydrolases
#18
Nicol Romero, José Benítez, David Garcia, Arlette González, Leonardo Bennun, María A García-Robles, Vasthi López, Liam A Wilson, Gerhard Schenk, Nelson Carvajal, Elena Uribe
Agmatine (1-amino-4-guanidinobutane) plays an important role in a range of metabolic functions, in particular in the brain. Agmatinases (AGMs) are enzymes capable of converting agmatine to the polyamine putrescine and urea. AGMs belong to the family of Mn(2+)-dependent ureahydrolases. However, no AGM from a mammalian source has yet been extracted in catalytically active form. While in human AGM the six amino acid ligands that coordinate the two Mn(2+) ions in the active site are conserved, four mutations are observed in the murine enzyme...
January 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27836390/agmatine-a-potential-novel-therapeutic-strategy-for-depression
#19
Andiara E Freitas, Vivian B Neis, Ana Lúcia S Rodrigues
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence of up to 20% worldwide. It is responsible for more years lost to disability than any other disorder. Despite the fact that current available antidepressant drugs are safe and effective, they are far from ideal. In addition to the need to administer the drugs for weeks or months to obtain clinical benefit, side effects are still a serious problem. Agmatine is an endogenous polyamine synthesized by the enzyme arginine decarboxylase...
December 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27810390/agmatine-ameliorates-type-2-diabetes-induced-alzheimer-s-disease-like-alterations-in-high-fat-diet-fed-mice-via-reactivation-of-blunted-insulin-signalling
#20
Somang Kang, Chul-Hoon Kim, Hosung Jung, Eosu Kim, Ho-Taek Song, Jong Eun Lee
The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promotes tau phosphorylation to cause AD. No therapeutic treatments that target AD in T2DM patients have yet been discovered. Agmatine, a primary amine derived from l-arginine, has exhibited anti-diabetic effects in diabetic animals...
February 2017: Neuropharmacology
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