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Agmatine

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https://www.readbyqxmd.com/read/28213886/dysregulation-of-metabolic-pathways-in-a-mouse-model-of-allergic-asthma
#1
Kevin D Quinn, Michaela Schedel, Yasmeen Nkrumah-Elie, Anthony Joetham, Michael Armstrong, Charmion Cruickshank-Quinn, Richard Reisdorph, Erwin W Gelfand, Nichole Reisdorph
BACKGROUND: Asthma is a complex lung disease resulting from the interplay of genetic and environmental factors. To understand the molecular changes that occur during the development of allergic asthma without genetic and environmental confounders, an experimental model of allergic asthma in mice was used. Our goals were to (1) identify changes at the small molecule level due to allergen exposure, (2) determine perturbed pathways due to disease, and (3) determine whether small molecule changes correlate with lung function...
February 18, 2017: Allergy
https://www.readbyqxmd.com/read/28178624/agmatine-enhances-the-antidepressant-like-effect-of-lithium-in-mouse-forced-swimming-test-through-nmda-pathway
#2
Gholmreza Mohseni, Sattar Ostadhadi, Muhammad Imran-Khan, Abbas Norouzi-Javidan, Samira Zolfaghari, Nazgol-Sadat Haddadi, Ahmad-Reza Dehpour
Depression is one the world leading global burdens leading to various comorbidities. Lithium as a mainstay in the treatment of depression is still considered gold standard treatment. Similar to lithium another agent agmatine has also central protective role against depression. Since, both agmatine and lithium modulate various effects through interaction with NMDA receptor, therefore, in current study we aimed to investigate the synergistic antidepressant-like effect of agmatine with lithium in mouse force swimming test...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28131838/phospholipase-c-dependent-hydrolysis-of-phosphatidylinositol-4-5-bisphosphate-underlies-agmatine-induced-suppression-of-n-type-ca-2-channel-in-rat-celiac-ganglion-neurons
#3
Young-Hwan Kim, Ji-Hyun Jeong, Duck-Sun Ahn, Seungsoo Chung
Agmatine suppresses peripheral sympathetic tone by modulating Cav2.2 channels in peripheral sympathetic neurons. However, the detailed cellular signaling mechanism underlying the agmatine-induced Cav2.2 inhibition remains unclear. Therefore, in the present study, we investigated the electrophysiological mechanism for the agmatine-induced inhibition of Cav2.2 current (ICav2.2) in rat celiac ganglion (CG) neurons. Consistent with previous reports, agmatine inhibited ICav2.2 in a VI manner. The agmatine-induced inhibition of the ICav2...
January 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28122652/effects-of-agmatine-sulphate-on-facial-nerve-injuries
#4
O Surmelioglu, L Sencar, S Ozdemir, O Tarkan, M Dagkiran, N Surmelioglu, U Tuncer, S Polat
OBJECTIVE: To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy. METHODS: The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination...
January 26, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28109885/hetero-and-homodimerization-of-arabidopsis-thaliana-arginine-decarboxylase-atadc1-and-atadc2
#5
Israel Maruri-López, Juan F Jiménez-Bremont
The arginine decarboxylase enzyme (ADC) carries out the production of agmatine from arginine, which is the precursor of the first polyamine (PA) known as putrescine; subsequently, putrescine is turned into the higher PAs, spermidine and spermine. In Arabidopsis thaliana PA production occurs only from arginine and this step is initiated by two ADC paralogues, AtADC1 and AtADC2. PA production is essential for A. thaliana life cycle. Here, we analyzed the sub-cellular localization of AtADC1 and AtADC2 enzymes through GFP translational fusions...
March 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28006753/agmatine-ameliorates-adjuvant-induced-arthritis-and-inflammatory-cachexia-in-rats
#6
Brijesh G Taksande, Dinesh Y Gawande, Chandrabhan T Chopde, Milind J Umekar, Nandkishor R Kotagale
The present study investigated the pharmacological effect of agmatine in Complete Freud Adjuvant (CFA) induced arthritis and cachexia in rats. The rats were injected with CFA (0.1ml/rat) to induced symptoms of arthritis. Day 8 onwards of CFA administration, rats were injected daily with agmatine for next 7days, and arthritis score, body weights and food intake were monitored daily (g). Since cachexia is known to produce severe inflammation, malnutrition and inhibition of albumin gene expression, we have also monitored the total proteins, albumin, TNF-α and IL-6 levels in arthritic rats and its modulation by agmatine...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27994462/novel-guanidinylated-bioresponsive-poly-amidoamine-s-designed-for-short-hairpin-rna-delivery
#7
Jiankun Yu, Jinmin Zhang, Haonan Xing, Yanping Sun, Zhen Yang, Tianzhi Yang, Cuifang Cai, Xiaoyun Zhao, Li Yang, Pingtian Ding
Two different disulfide (SS)-containing poly(amidoamine) (PAA) polymers were constructed using guanidino (Gua)-containing monomers (ie, arginine [Arg] and agmatine [Agm]) and N,N'-cystamine bisacrylamide (CBA) by Michael-addition polymerization. In order to characterize these two Gua-SS-PAA polymers and investigate their potentials as short hairpin RNA (shRNA)-delivery carriers, pSilencer 4.1-CMV FANCF shRNA was chosen as a model plasmid DNA to form complexes with these two polymers. The Gua-SS-PAAs and plasmid DNA complexes were determined with particle sizes less than 90 nm and positive ζ-potentials under 20 mV at nucleic acid:polymer weight ratios lower than 1:24...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27993640/protective-effects-of-agmatine-on-doxorubicin-induced-chronic-cardiotoxicity-in-rat
#8
Fatemeh Yarmohmmadi, Nastaran Rahimi, Hedyeh Faghir-Ghanesefat, Nina Javadian, Alireza Abdollahi, Parvin Pasalar, Farahnaz Jazayeri, Shahram Ejtemaeemehr, Ahmad Reza Dehpour
The detrimental cardio-toxic effect of doxorubicin, an effective chemotherapeutic agent, limited its clinical use. It has been claimed that doxorubicin cardio-toxicity occurs through calcium ions (Ca(2+)) overload and reactive oxygen species production. Agmatine, an endogenous imidazoline receptor agonist, induce uptake of cytosolic Ca(2+) and cause an increase in activity of calcium pumps, including Ca(2+)-ATPase. Also it shows self-scavenging effect against reactive oxygen species production. Therefore, present study was designed to investigate the effects of agmatine against chronic cardio-toxicity of doxorubicin in rats...
December 16, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27988355/agmatine-modulates-melanogenesis-via-mitf-signaling-pathway
#9
Eun-Jeong Kwon, Moon-Moo Kim
Agmatine contained in soybean is also found in Manaca, an anti-aging plant, inhabited in Amazon and induces vasodilation by the promotion of NO synthesis in blood vessel. However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. It was determined whether agmatine regulates melanin synthesis at cellular level in addition to the effect of agmatine on mushroom tyrosinase in vitro in the presence of different concentrations of agmatine...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27934648/arginine-metabolism-revisited
#10
REVIEW
Sidney M Morris
Mammalian arginine metabolism is complex due to the expression of multiple enzymes that utilize arginine as substrate and to interactions or competition between specific enzymes involved in arginine metabolism. Moreover, cells may contain multiple intracellular arginine pools that are not equally accessible to all arginine metabolic enzymes, thus presenting additional challenges to more fully understanding arginine metabolism. At the whole-body level, arginine metabolism ultimately results in the production of a biochemically diverse range of products, including nitric oxide, urea, creatine, polyamines, proline, glutamate, agmatine, and homoarginine...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27899287/pre-treatment-with-vinpocetine-protects-against-retinal-ischemia
#11
Lisa Nivison-Smith, Pauline Khoo, Monica L Acosta, Michael Kalloniatis
Vinpocetine has been shown to have beneficial effects for tissues of the central nervous system subjected to ischemia and other related metabolic insults. We recently showed vinpocetine promotes glucose availability, prevents unregulated cation channel permeability and regulates glial reactivity when present during retinal ischemia. Less is known however about the ability of vinpocetine to protect against future ischemic insults. This study explores the effect of vinpocetine when used as a pre-treatment in an ex vivo model for retinal ischemia using cation channel permeability of agmatine (AGB) combined with immunohistochemistry as a measure for cell functionality...
November 27, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27873165/analysing-the-effect-of-i1-imidazoline-receptor-ligands-on-dss-induced-acute-colitis-in-mice
#12
Ágnes Fehér, Viktória E Tóth, Mahmoud Al-Khrasani, Mihály Balogh, Bernadette Lázár, Zsuzsanna Helyes, Klára Gyires, Zoltán S Zádori
Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases; and moxonidine and rilmenidine, agonists of I1-IRs, are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or other molecular targets, which could be beneficial in patients with inflammatory bowel disease (IBD). On the other hand, several IR ligands may stimulate also alpha2-adrenoceptors, which were earlier shown to inhibit, but in more recent studies to rather aggravate colitis...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/27846445/mammalian-agmatinases-constitute-unusual-members-in-the-family-of-mn-2-dependent-ureahydrolases
#13
Nicol Romero, José Benítez, David Garcia, Arlette González, Leonardo Bennun, María A García-Robles, Vasthi López, Liam A Wilson, Gerhard Schenk, Nelson Carvajal, Elena Uribe
Agmatine (1-amino-4-guanidinobutane) plays an important role in a range of metabolic functions, in particular in the brain. Agmatinases (AGMs) are enzymes capable of converting agmatine to the polyamine putrescine and urea. AGMs belong to the family of Mn(2+)-dependent ureahydrolases. However, no AGM from a mammalian source has yet been extracted in catalytically active form. While in human AGM the six amino acid ligands that coordinate the two Mn(2+) ions in the active site are conserved, four mutations are observed in the murine enzyme...
January 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27836390/agmatine-a-potential-novel-therapeutic-strategy-for-depression
#14
Andiara E Freitas, Vivian B Neis, Ana Lúcia S Rodrigues
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence of up to 20% worldwide. It is responsible for more years lost to disability than any other disorder. Despite the fact that current available antidepressant drugs are safe and effective, they are far from ideal. In addition to the need to administer the drugs for weeks or months to obtain clinical benefit, side effects are still a serious problem. Agmatine is an endogenous polyamine synthesized by the enzyme arginine decarboxylase...
December 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27810390/agmatine-ameliorates-type-2-diabetes-induced-alzheimer-s-disease-like-alterations-in-high-fat-diet-fed-mice-via-reactivation-of-blunted-insulin-signalling
#15
Somang Kang, Chul-Hoon Kim, Hosung Jung, Eosu Kim, Ho-Taek Song, Jong Eun Lee
The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promotes tau phosphorylation to cause AD. No therapeutic treatments that target AD in T2DM patients have yet been discovered. Agmatine, a primary amine derived from l-arginine, has exhibited anti-diabetic effects in diabetic animals...
February 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27801550/herring-and-chicken-pork-meals-lead-to-differences-in-plasma-levels-of-tca-intermediates-and-arginine-metabolites-in-overweight-and-obese-men-and-women
#16
Andrew Vincent, Otto I Savolainen, Partho Sen, Nils-Gunnar Carlsson, Annette Almgren, Helen Lindqvist, Mads Vendelbo Lind, Ingrid Undeland, Ann-Sofie Sandberg, Alastair B Ross
SCOPE: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome. METHOD AND RESULTS: A randomized crossover trial with fifteen healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics...
November 1, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27774136/combined-interactions-with-i1-i2-imidazoline-binding-sites-and-%C3%AE-2-adrenoceptors-to-manage-opioid-addiction
#17
Maria Elena Giusepponi, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura, Laura Mattioli, Alan Hudson, Eleonora Diamanti, Fabio Del Bello, Mario Giannella, Valerio Mammoli, Corinne Dalila Paoletti, Alessandro Piergentili, Maria Pigini, Wilma Quaglia
Tolerance and dependence associated with chronic opioid exposure result from molecular, cellular, and neural network adaptations. Such adaptations concern opioid and nonopioid systems, including α2-adrenoceptors (α2-ARs) and I1- and I2-imidazoline binding sites (IBS). Agmatine, one of the hypothesized endogenous ligands of IBS, targeting several systems including α2-ARs and IBS, proved to be able to regulate opioid-induced analgesia and to attenuate the development of tolerance and dependence. Interested in the complex pharmacological profile of agmatine and considering the nature of its targets, we evaluated two series of imidazolines, rationally designed to simultaneously interact with I1-/I2-IBS or I1-/I2-IBS/α2-ARs...
October 13, 2016: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27764887/uptake-pathways-of-guandinylated-disulfide-containing-polymers-as-nonviral-gene-carrier-delivering-dna-to-cells
#18
Jinmin Zhang, Jiankun Yu, Jingzheng Jiang, Xiao Chen, Yanping Sun, Zhen Yang, Tianzhi Yang, Cuifang Cai, Xiaoyun Zhao, Pingtian Ding
Polymers of guanidinylated disulfide containing poly(amido amine)s (Gua-SS-PAAs), have shown high transfection efficiency and low cytotoxicity. Previously, we synthesized two Gua-SS-PAA polymers, using guanidino containing monomers (i.e., arginine and agmatine, denoted as ARG and AGM, respectively) and N,N'-cystaminebisacrylamide (CBA). In this study, these two polymers, AGM-CBA and ARG-CBA were complexed with plasmid DNA, and their uptake pathway was investigated. Complexes distribution in MCF-7 cells, and changes on cell endosomes/lysosomes and membrane after the cells were exposed to complexes were tested...
October 20, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27743829/acute-agmatine-administration-similar-to-ketamine-reverses-depressive-like-behavior-induced-by-chronic-unpredictable-stress-in-mice
#19
Vivian B Neis, Luis E B Bettio, Morgana Moretti, Priscila B Rosa, Camille M Ribeiro, Andiara E Freitas, Filipe M Gonçalves, Rodrigo B Leal, Ana Lúcia S Rodrigues
Agmatine is an endogenous neuromodulator that has been shown to have antidepressant-like properties. We have previously demonstrated that it can induce a rapid increase in BDNF levels after acute administration, suggesting that agmatine may be a fast-acting antidepressant. To investigate this hypothesis, the present study evaluated the effects of a single administration of agmatine in mice subjected to chronic unpredictable stress (CUS), a model of depression responsive only to chronic treatment with conventional antidepressants...
November 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27729248/new-2-aminothiazoline-derivatives-lower-blood-pressure-of-spontaneously-hypertensive-rats-shr-via-i1-imidazoline-and-alpha-2-adrenergic-receptors-activation
#20
Renan B Ferreira, Mariana G de Oliveira, Edson Antunes, Wanda P Almeida, Badr M Ibrahim, Abdel A Abdel-Rahman
2-Aminothiazolines share an isosteric relationship with imidazolines and oxazolines with antihypertensive activity mainly mediated by the imidazoline I1-receptor. In the present work, we have prepared five aminothiazolines, following a previously described synthetic pathway. Aminothiazolines derived from dicyclopropylmethylamine (ATZ1) and cyclohexylamine (3) are unprecedented in the literature. Competitive radioligand assay was carried out with all synthetic compounds, and the I1 receptor affinity in comparison to rilmenidine in PC12 cells was determined...
November 15, 2016: European Journal of Pharmacology
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