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Neurocysticercosis

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https://www.readbyqxmd.com/read/28226078/experimental-neurocysticercosis-absence-of-il-4-induces-lower-encephalitis
#1
Hidelberto Matos Silva, Marina Clare Vinaud, Ruy de Souza Lino
Methods: BALB/c (WT) and BALB/c (IL-4-KO) mice were inoculated intracranially with Taenia crassiceps cysticerci and euthanized at 7, 30, 60 and 90 days later, the encephala removed and histopathologically analyzed. Results: The absence of IL-4 induced greater parasitism. In the initial phase of the infection, IL-4-KO showed a lower intensity in the inflammatory infiltration of polimorphonuclear cells in the host-parasite interface and intra-parenquimatous edema...
February 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28216368/in-vitro-and-in-vivo-cysticidal-activity-of-extracts-and-isolated-flavanone-from-the-bark-of-prunus-serotina-a-bio-guided-study
#2
Francisca Palomares-Alonso, Irma Susana Rojas-Tomé, Guadalupe Palencia Hernández, María Adelina Jiménez-Arellanes, Martha Lydia Macías-Rubalcava, Angélica González-Maciel, Andrea Ramos-Morales, Rosalba Santiago-Reyes, Nelly Castro, Iliana González-Hernández, Yadira Rufino-González, Helgi Jung-Cook
Currently, neurocysticercosis treatment involves two drugs: albendazole and praziquantel; however, their efficacy is suboptimal and new cysticidal drugs are needed. The present paper reports the cysticidal activity of extracts of the bark from Prunus serotina against Taenia crassiceps cysts and the isolation and identification of the main components of the most active extract. Results showed that all extracts displayed in vitro cysticidal activity (EC50=17.9-88.5μg/mL), being the methanolic the most active and selective...
February 16, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28215871/disease-behaviours-of-sows-naturally-infected-with-taenia-solium-in-tanzania
#3
Chiara Trevisan, Maria Vang Johansen, Ernatus Martin Mkupasi, Helena Aminel Ngowi, Björn Forkman
Neurocysticercosis (NCC) is a disease caused by the zoonotic parasite Taenia solium lodging in the central nervous system. Both humans and pigs can get NCC. The impact of the disease in pigs has so far been little explored. The aim of this study was to describe the effect of NCC on social and feeding behaviours as well as the pattern of activity as indicators of reduced welfare in naturally infected sows. In total 13 T. solium naturally infected and 15 non-infected control sows were videotaped for 2 consecutive weeks using close circuit television cameras at research facilities at Sokoine University of Agriculture, Morogoro, Tanzania...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28212398/modelling-the-risk-of-taenia-solium-exposure-from-pork-produced-in-western-kenya
#4
Lian F Thomas, William A de Glanville, Elizabeth A J Cook, Barend M De C Bronsvoort, Ian Handel, Claire N Wamae, Samuel Kariuki, Eric M Fèvre
The tapeworm Taenia solium is the parasite responsible for neurocysticercosis, a neglected tropical disease of public health importance, thought to cause approximately 1/3 of epilepsy cases across endemic regions. The consumption of undercooked infected pork perpetuates the parasite's life-cycle through the establishment of adult tapeworm infections in the community. Reducing the risk associated with pork consumption in the developing world is therefore a public health priority. The aim of this study was to estimate the risk of any one pork meal in western Kenya containing a potentially infective T...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28183336/assessing-the-impact-of-intervention-strategies-against-taenia-solium-cysticercosis-using-the-epicyst-transmission-model
#5
Peter Winskill, Wendy E Harrison, Michael D French, Matthew A Dixon, Bernadette Abela-Ridder, María-Gloria Basáñez
BACKGROUND: The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organization (WHO) has set goals for having a validated strategy for control and elimination of T. solium taeniasis/cysticercosis by 2015 and interventions scaled-up in selected countries by 2020. Timely achievement of these internationally-endorsed targets requires that the relative benefits and effectiveness of potential interventions be explored rigorously within a quantitative framework...
February 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28174186/avoiding-misdiagnosis-cystic-calcified-brain-metastases-of-uterine-cervical-cancer-mimicking-neurocysticercosis
#6
Jacopo Fantini, Arianna Sartori, Paolo Manganotti
The radiological finding of multiple calcified brain lesions is atypical for brain metastases and in absence of a clear evidence of disseminated neoplastic disease the differential diagnosis may be difficult. Calcified brain metastases (CBM) are rarely encountered in clinical practice and they mostly arise from lung, breast and gastrointestinal primitive tumours. Only one case of uterine cervical carcinoma (UCC) with CBM has been reported so far. We describe the case of a 41-year-old Caucasian woman with a history of hysterectomy and bilateral salpingo-oophorectomy for UCC 3 years prior to observation and no evidence of neoplastic recurrence that developed cystic CBM...
February 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28167968/prevalence-response-to-cysticidal-therapy-and-risk-factors-for-persistent-seizure-in-indian-children-with-neurocysticercosis
#7
Animesh Kumar, Anirban Mandal, Sheela Sinha, Amitabh Singh, Rashmi Ranjan Das
Background. Neurocysticercosis (NCC) is the commonest cause of childhood acquired epilepsy in developing countries. The use of cysticidal therapy in NCC, except "single lesion NCC," is still debated in view of its doubtful usefulness and potential adverse effects. Methods. Children presenting with first episode of seizure or acute focal neurological deficit without fever were screened for NCC and received appropriate therapy (followup done for 1 year to look for the response and side effects). Results. The prevalence of NCC was 4...
2017: International Journal of Pediatrics
https://www.readbyqxmd.com/read/28146039/a-rare-ocular-presentation-of-metastatic-lung-cancer-unilateral-anterior-chamber-angle-bilateral-choroidal-and-multiple-intracranial-metastases
#8
Amber Hoang, Kay T Khine, O'Rese J Knight, Rachel A Tesser, David A Chesnutt
A 64-year-old man who presented with photopsia was found to have elevated intraocular pressure in one eye and optic disc swelling in the other eye. He was initially diagnosed with neurocysticercosis and later metastatic lung adenocarcinoma. The purpose of this paper is to report a rare case of bilateral glare as the first sign of diffusely metastatic cancer and to raise clinical suspicion for systemic malignancy in the presence of multiple ocular manifestations.
February 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28143423/report-of-three-imported-cases-of-neurocysticercosis-in-guadeloupe
#9
R Blaizot, B Melot, K Schepers, M Nicolas, S Gaumond, P Poullain, L Belaye, A Lannuzel, B Hoen
BACKGROUND: Neurocysticercosis is endemic in most countries of Central and South America but has rarely been described in the French West Indies. We aimed to better understand the clinical and radiological presentation of our cases. CASE PRESENTATION: We report three cases of neurocysticercosis in patients living in Guadeloupe, with different clinical and radiological presentations. CONCLUSION: Given the eventuality of autochtonous transmission, the diagnosis should be considered in all patients living in Guadeloupe presenting with seizures...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28139530/neurocysticercosis-diagnostic-problems-current-therapeutic-strategies
#10
REVIEW
Vedantam Rajshekhar
Neurocysticercosis (NCC) is the most common single cause of seizures/epilepsy in India and several other endemic countries throughout the world. It is also the most common parasitic disease of the brain caused by the cestode Taenia solium or pork tapeworm. The diagnosis of NCC and the tapeworm carrier (taeniasis) can be relatively inaccessible and expensive for most of the patients. In spite of the introduction of several new immunological tests, neuroimaging remains the main diagnostic test for NCC. The treatment of NCC is also mired in controversy although, there is emerging evidence that albendazole (a cysticidal drug) may be beneficial for patients by reducing the number of seizures and hastening the resolution of live cysts...
September 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28105460/validity-of-a-pcr-assay-in-csf-for-the-diagnosis-of-neurocysticercosis
#11
Arturo Carpio, Alfredo Campoverde, Matthew L Romo, Lorena García, Luis M Piedra, Mónica Pacurucu, Nelson López, Jenner Aguilar, Sebastian López, Luis C Vintimilla, Ana M Toral, Pablo Peña-Tapia
OBJECTIVE: To prospectively evaluate the validity of a PCR assay in CSF for the diagnosis of neurocysticercosis (NC). METHODS: We conducted a multicenter, prospective case-control study, recruiting participants from 5 hospitals in Cuenca, Ecuador, from January 2015 to February 2016. Cases fulfilled validated diagnostic criteria for NC. For each case, a neurosurgical patient who did not fulfill the diagnostic criteria for NC was selected as a control. CT and MRI, as well as a CSF sample, were collected from both cases and controls...
March 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28077750/the-association-between-neurocysticercosis-and-hippocampal-atrophy-is-related-to-age
#12
Oscar H Del Brutto, Naoum P Issa, Perla Salgado, Victor J Del Brutto, Mauricio Zambrano, Julio Lama, Héctor H García
Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case-control study design, residents in a rural village (Atahualpa) aged ≥ 40 years with calcified NCC were identified as cases and paired to NCC-free individuals (control subjects) matched by age, sex, and level of education. Cases and control subjects underwent magnetic resonance imaging for hippocampal rating according to the Scheltens' scale for medial temporal atrophy and were interviewed to identify those with a clinical seizure disorder...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28077749/survey-of-obstetrician-gynecologists-in-the-united-states-about-taeniasis-and-cysticercosis
#13
Rebecca L Hall, Britta Anderson, Jay Schulkin, Paul T Cantey, Susan P Montgomery, Jeffrey L Jones
An estimated 50 million persons worldwide are infected with cysticerci, the larval forms of the Taenia solium tapeworm. Neurocysticercosis can cause seizures, epilepsy, and hydrocephalus, and fatal cases have been reported in the United States in immigrants and in travelers returning from endemic countries. Pregnant women with symptomatic neurocysticercosis present treatment challenges, whereas those with the adult tapeworm infection (i.e., taeniasis) can put their infants and other family members, as well as obstetrician-gynecologists and their staff, at risk for cysticercosis...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28060040/long-term-clinical-and-radiologic-outcome-of-500-children-with-parenchymal-neurocysticercosis
#14
Pratibha Singhi, Renu Suthar, Brijendra Deo, Prabhjot Malhi, N K Khandelwal
BACKGROUND: Our aim was to study long-term clinical and radiologic outcome of children with parenchymal neurocysticercosis (NCC) and its predictors. METHOD: 500 children with NCC registered in the pediatric NCC Clinic between January 1996 and December 2002 and followed to December 2009 were enrolled. Demographic details, clinical presentations and therapy received were recorded. Outcome was evaluated in terms of seizure recurrence and resolution of lesions on neuroimaging...
January 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28053392/isolated-intramuscular-cysticercosis-clinicopathological-features-diagnosis-and-management-a-review
#15
REVIEW
Durgashankar Meena, Mayank Gupta, Vijay Kumar Jain, Rajendra Kumar Arya
Cysticercosis is an emerging parasitic disease affecting worldwide population. There is large volume of data present in the literature for neurocysticercosis. The isolated intramuscular involvement of cysticercosis is uncommon and there are only sporadic case reports available. There is no review available in the literature which gives in detail clinicoradiological features and management of isolated intramuscular cysticercosis. Knowledge about such a presentation is important especially in developing countries and to differentiate the condition from a variety of other similar conditions...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28033226/mobile-subretinal-cysticercus-imaged-by-spectral-domain-optical-coherence-tomography-with-motion-tracker
#16
Ravi Bypareddy, Brijesh Takkar, Rohan Chawla, Neha Sachdeva, Shorya V Azad, Koushik Tripathy
PURPOSE: To report optical coherence tomography-based videoimaging of alive subretinal cysticercus along with its mobile scolex. METHODS: Spectral-domain optical coherence tomography was used to record high-definition videoimages, using the inbuilt motion tracker, in a 12-year-old boy with history of neurocysticercosis. RESULT: The scolex was found to be sensitive to light, and contractile movements were seen in the cyst wall and the germinative layers...
December 28, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28025397/lingual-epilepsia-partialis-continua-in-neurocysticercosis
#17
Sachin Sureshbabu, Dinesh Nayak, Gaurav Mittal, Sudhir Peter, Chindripu Sobhana, Vikash Aggarwal
No abstract text is available yet for this article.
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/28017213/revised-diagnostic-criteria-for-neurocysticercosis
#18
REVIEW
O H Del Brutto, T E Nash, A C White, V Rajshekhar, P P Wilkins, G Singh, C M Vasquez, P Salgado, R H Gilman, H H Garcia
BACKGROUND: A unified set of criteria for neurocysticercosis (NCC) has helped to standardize its diagnosis in different settings. METHODS: Cysticercosis experts were convened to update current diagnostic criteria for NCC according to two principles: neuroimaging studies are essential for diagnosis, and all other information provides indirect evidence favoring the diagnosis. Recent diagnostic advances were incorporated to this revised set. RESULTS: This revised set is structured in absolute, neuroimaging and clinical/exposure criteria...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28013026/nonsubsampled-rotated-complex-wavelet-transform-nsrcxwt-for-medical-image-fusion-related-to-clinical-aspects-in-neurocysticercosis
#19
Satishkumar S Chavan, Abhishek Mahajan, Sanjay N Talbar, Subhash Desai, Meenakshi Thakur, Anil D'cruz
Neurocysticercosis (NCC) is a parasite infection caused by the tapeworm Taenia solium in its larvae stage which affects the central nervous system of the human body (a definite host). It results in the formation of multiple lesions in the brain at different locations during its various stages. During diagnosis of such symptomatic patients, these lesions can be better visualized using a feature based fusion of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). This paper presents a novel approach to Multimodality Medical Image Fusion (MMIF) used for the analysis of the lesions for the diagnostic purpose and post treatment review of NCC...
February 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28012796/antigenic-fractions-from-taenia-crassiceps-metacestodes-obtained-by-hydrophobicity-for-the-immunodiagnosis-of-active-and-inactive-forms-of-neurocysticercosis-in-human-cerebrospinal-fluid-samples
#20
Gabriela B da Silva, Daniela S Nunes, José Eduardo N de Sousa, Maria do R F Gonçalves-Pires, Marcelo A Levenhagen, Julia M Costa-Cruz
This study aimed to evaluate the total extract of Taenia crassiceps metacestodes (TC) and its antigenic fractions obtained by Triton X-114 fractionation techniques, such as detergent (DC) and aqueous (AC), in the immunodiagnosis of human neurocysticercosis (NCC). Cerebrospinal fluid samples were divided into two groups: Group 1 (n=40), which was further divided into active (n=20) and inactive (n=20) NCC, and Group 2 (control group), which comprised 39 CSF samples from patients who had another neurological disorder, were suffering from other infectious diseases of the brain or had other parasitic infections...
April 2017: Parasitology International
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