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Neurocysticercosis

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https://www.readbyqxmd.com/read/28739367/a-hyperendemic-focus-of-taenia-solium-transmission-in-the-banke-district-of-nepal
#1
Keshav Sah, Ishab Poudel, Suyog Subedi, Dinesh Kumar Singh, Jo Cocker, Peetambar Kushwaha, Angela Colston, Meritxell Donadeu, Marshall W Lightowlers
Neurocysticercosis is a major cause of epilepsy in countries where Taenia solium is endemic and the parasite is a major cause of food-borne disease globally. Pigs are the natural intermediate host involved in transmission of the parasite. T. solium is known to be endemic in Nepal, however there is limited reliable data about the prevalence of the disease in Nepal. The aim of this study was to determine accurately the prevalence of porcine cysticercosis in slaughter age pigs in an area of Nepal where pigs are known to be free-roaming...
July 21, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28716274/head-ct-findings-at-a-public-hospital-in-rural-haiti
#2
Yannis K Valtis, Maggie F Cochran, Louine Martineau, Bregenet Lamour, Jeffrey B Mendel, Aaron L Berkowitz
BACKGROUND: Neuroimaging is often unavailable in low-income countries, creating challenges for precise diagnosis of neurologic disease in individual patients, and impeding acquisition of precise neuroepidemiologic data for program and policy development. METHODS: We analyzed reports from 3614 head CTs performed between July 2013 and January 2016 at Hôpital Universitaire de Mirebalais, a public academic hospital in rural Haiti, extracting patients' age, study indication, and radiologic findings...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28714494/computerized-axial-tomography-findings-in-children-with-afebrile-seizures-a-hospital-based-study-at-eastern-nepal
#3
P Poudel, M K Gupta, S P Kafle
BACKGROUND: Computerized Tomography can be performed in resource limited areas where Magnetic Resonance Imaging is less practical. This study was conducted to find out the proportion of cases with abnormal CT scan and findings of CT scan in children with afebrile seizures in a resource limited area. METHODS: This prospective study was conducted from 1st July 2009 to 31st March 2014 in a university hospital of Nepal. Patients (1 month to 20 years of age) presenting with history of afebrile seizure were included...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28713592/clinicodemographic-profile-of-children-with-seizures-in-a-tertiary-care-hospital-a-cross-sectional-observational-study
#4
Nagendra Chaudhary, Murli Manohar Gupta, Sandeep Shrestha, Santosh Pathak, Om Prakash Kurmi, B D Bhatia, K N Agarwal
Seizures are one of the common causes for hospital admissions in children with significant mortality and morbidity. This study was conducted to study the prevalence and clinicodemographic profile of children with seizures in a tertiary care hospital of western Nepal. This prospective cross-sectional study conducted over a period of 2 years included all admitted children (2 months-16 years) with seizures. Among 4962 admitted children, seizures were present in 3.4% (n = 168) of children, with male preponderance...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28711539/transventricular-migration-of-neurocysticercosis
#5
Abhidha Shah, Ravikiran Vutha, Shilpa Sankhe, Atul Goel
BACKGROUND: The movements of a neurocysticercosis cyst within the ventricular cavity have been identified rarely. CASE DESCRIPTION: A 22-year old male patient presented with the main symptom of diplopia for about a week. Findings of the neurologic examination revealed bilateral sixth cranial nerve weakness. Investigations during the period showed an intraventricular tumor that migrated from lateral ventricle to the third ventricle and subsequently to the fourth ventricle...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28711534/primary-intradural-extramedullary-cervical-spinal-cysticercosis
#6
Vetrivel Muralidharan, Bijesh Ravindran Nair, Bimal Patel, Vedantam Rajshekhar
BACKGROUND: Spinal cysticercosis has been reported in 0.7%-3.0% of patients with neurocysticercosis. Most patients with spinal cysticercosis have a coexisting intracranial disease. Most often this intracranial disease manifests as intradural extramedullary lesions involving thoracic and lumbar regions or intramedullary lesions. Intradural extramedullary primary spinal cysticercosis manifesting as cervical myelopathy is extremely rare and has not been reported to date. CASE DESCRIPTION: A 56-year-old man from the northeastern part of India presented with progressive spastic quadriparesis...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28686662/comparison-of-a-new-multiplex-real-time-pcr-with-the-kato-katz-thick-smear-and-copro-antigen-elisa-for-the-detection-and-differentiation-of-taenia-spp-in-human-stools
#7
COMPARATIVE STUDY
Dinh Ng-Nguyen, Mark A Stevenson, Pierre Dorny, Sarah Gabriël, Tinh Van Vo, Van-Anh Thi Nguyen, Trong Van Phan, Sze Fui Hii, Rebecca J Traub
BACKGROUND: Taenia solium, the cause of neurocysticercosis (NCC), has significant socioeconomic impacts on communities in developing countries. This disease, along with taeniasis is estimated to infect 2.5 to 5 million people globally. Control of T. solium NCC necessitates accurate diagnosis and treatment of T. solium taeniasis carriers. In areas where all three species of Taenia tapeworms (T. solium, Taenia saginata and Taenia asiatica) occur sympatrically, conventional microscope- and copro-antigen based diagnostic methods are unable to distinguish between these three Taenia species...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28676219/de-novo-cystic-brain-lesions-mimicking-neurocysticercosis-in-alk-positive-lung-cancer
#8
Su-Hyun Kim, Jae-Won Hyun, Ho Jin Kim, Ho-Shin Gwak, Sang Hyun Lee, Eun-Kyung Hong, Youngjoo Lee
Cystic brain metastases (CBM) have been recently reported in a minority of patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). All previously reported ALK-positive CBM developed during crizotinib treatment and were often asymptomatic and indolent, even without CNS-directed therapy. Thus, crizotinib was suggested as an etiologic agent for the development of CBM. Here, we report a case of de novo CBM in a patient with ALK-positive NSCLC prior to crizotinib treatment; the ALK-positive NSCLC had initially been misdiagnosed as neurocysticercosis because of the atypical radiological presentation of brain metastases...
August 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28673685/controversies-in-the-treatment-of-seizures-associated-with-neurocysticercosis
#9
REVIEW
Gagandeep Singh, Ravina Sharma
Seizures are the commonest manifestation of brain parenchymal cysticercosis. In terms of pathophysiological basis and prognostic significance of the seizures, a distinction might be applied between viable cysts, solitary cysticercus granuloma and calcific cysticerci. A number of uncertainties shroud the management of seizures in people with neurocysticercosis (NCC). Although antihelminthic treatment is effective in eliminating viable cysts and possibly cysticercus granulomas, its effect on seizure outcome remains uncertain...
June 30, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28673613/parkinsonism-and-other-movement-disorders-in-23-cases-of-neurocysticercosis
#10
Fernando Alarcón, Yuri Cedeño, Justo García de Yébenes
INTRODUCTION: Parkinsonism and other movement disorders have been occasionally described in neurocysticercosis (NCC) but their clinical features and pathogenesis are not well understood. METHODS: This is a descriptive study conducted over 20 years. We studied 590 consecutive patients from the NCC Registry at Eugenio Espejo Hospital, Quito, Ecuador, and found 23 subjects who developed movement disorders. We investigated the clinical features, localization of brain lesions, severity of infection and neurological deficit as well as the outcome of the patients...
June 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28670090/neurocysticercosis-of-the-fourth-ventricle-associated-with-hydrocephalus
#11
Carola Mullins, Jonathan A Muniz, Hugo Sandoval, Osvaldo Padilla, Luis Ramos-Duran
Neurocysticercosis is a parasitic infection of the central nervous system with the cysts of Taenia solium, the pig tapeworm. Infection presents with a pleomorphic picture depending on the stage and location of the infection and the immune response of the infected host. Historically confined to the developing world, neurocysticercosis is no longer limited to endemic regions, as globalization, travel, and immigration permit the spread of the infection. We report a young Hispanic patient who was diagnosed with neurocysticercosis of the fourth ventricle and subsequent hydrocephalus...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28669015/present-status-of-laboratory-diagnosis-of-human-taeniosis-cysticercosis-in-europe
#12
REVIEW
M A Gómez-Morales, T Gárate, J Blocher, B Devleesschauwer, G S A Smit, V Schmidt, M J Perteguer, A Ludovisi, E Pozio, P Dorny, S Gabriël, A S Winkler
Human cysticercosis (CC) is a parasitic zoonosis caused by the larval stage (cyst) of the Taenia solium. Cysts can establish in the human central nervous system (neurocysticercosis, NCC) and other organs and tissues; they also develop in pigs, the natural intermediate host. Human taeniosis may be caused by T. solium, Taenia saginata and Taenia asiatica tapeworms; these infections are usually asymptomatic, but show a significant relevance as they perpetuate the parasites' life cycle, and, in the case of T. solium, they are the origin of (N)CC...
July 1, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28658758/a-stratified-analysis-of-clinical-manifestations-and-different-diagnostic-methods-of-neurocysticercosis-suspected-tamilian-population-residing-in-and-around-puducherry
#13
Piriyatharisini Thamilselvan, Krishna Raja Muthuraman, Sheeba Arockiamary Thasan, Gayathri Kasinathan, Jharna Mandal, Subhash Chandra Parija
INTRODUCTION: Human beings are accidental hosts for Cysticercus cellulosae showing varied clinical manifestations based on the site harbored by the parasitic cyst because of which disease profile remains unexplored at large. Besides this, diagnosis of the disease with a single conventional method is problematic due to lack of specificity and sensitivity. AIM: To assess the varied clinical manifestations and stratify based on imaging and serological methods for diagnosis of Neurocysticercosis (NCC) in our study population...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28643983/-an-underestimated-cause-of-seizure-in-europe
#14
Chloé Godoffe, Pierrick Le Borgne, Claire Kam, Mihaela Mihalcea-Danciu, Pascal Bilbault, Philippe Kauffmann
Seizures are very common in the Emergency Department (ED). We present here a case of a young woman with neurocysticercosis ; a worldwide and nearly endemic cause of seizure in the southern hemisphere. Clinical manifestations are very different between patients from asymptomatic to life-threatening hydrocephalus. Diagnosis is based on a combination of clinical presentation, neuroimaging (CT and MRI) findings, history of exposure, and serologic testing.
June 14, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28622332/comparison-of-monocyte-gene-expression-among-patients-with-neurocysticercosis-associated-epilepsy-idiopathic-epilepsy-and-idiopathic-headaches-in-india
#15
COMPARATIVE STUDY
Vasudevan Prabhakaran, Douglas A Drevets, Govindan Ramajayam, Josephine J Manoj, Michael P Anderson, Jay S Hanas, Vedantam Rajshekhar, Anna Oommen, Hélène Carabin
BACKGROUND: Neurocysticercosis (NCC), a neglected tropical disease, inflicts substantial health and economic costs on people living in endemic areas such as India. Nevertheless, accurate diagnosis using brain imaging remains poorly accessible and too costly in endemic countries. The goal of this study was to test if blood monocyte gene expression could distinguish patients with NCC-associated epilepsy, from NCC-negative imaging lesion-free patients presenting with idiopathic epilepsy or idiopathic headaches...
June 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28615981/human-taeniasis-current-insights-into-prevention-and-management-strategies-in-endemic-countries
#16
REVIEW
Anna L Okello, Lian Francesca Thomas
Human taeniasis is a zoonotic condition resulting from infection with the adult stages of Taenia saginata ("beef tapeworm"), Taenia solium ("pork tapeworm") or Taenia asiatica ("Asian tapeworm"). Although these parasites have a worldwide distribution, the overwhelming burden is felt by communities in low- and middle-income countries. This is particularly true for T. solium, whereby infection of the central nervous system with the larval stage of the parasite (neurocysticercosis) is a major cause of acquired epilepsy in low-resource settings...
2017: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/28607832/headaches-more-common-among-epilepsy-sufferers-with-neurocysticercosis-than-other-structural-brain-lesions
#17
Erin K Saito, Bijal Mehta, Frances Wang, Beau Nakamoto, Aaron M McMurtray
Neurocysticercosis is a leading cause of seizures and epilepsy in the developing world. Cysticercosis is endemic in many regions of Central and South America, sub-Saharan Africa, India, and Asia. Neurocysticercosis is of emerging importance because globalization has increased travel between Hawai'i and disease-endemic areas. Headache and epilepsy are two of the most common complications of neurocysticercosis infection. Currently, it is not known if epilepsy patients with neurocysticercosis are more likely to have headaches than those with other structural brain lesions or those with no structural brain abnormalities...
June 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28606690/antiparasitic-treatment-of-neurocysticercosis-the-effect-of-cyst-destruction-in-seizure-evolution
#18
REVIEW
Hector H Garcia, Oscar H Del Brutto
Antiparasitic agents against Taenia solium cysticercosis have been in use since 1979, although its use has been questioned on the basis that cysts would die naturally and thus treatment-induced inflammation is unnecessary. In addition, isolated reports have also questioned whether neurocysticercosis (NCC) is a cause of epilepsy. After more than three and a half decades, a large body of evidence is available. Little if any doubt exists about NCC as a cause of seizures - NCC is consistently associated with seizures when appropriate groups are compared, and in a large subset of cases, seizure semiology correlates with the anatomical location of lesions...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28602886/primary-spinal-intramedullary-neurocysticercosis-a-report-of-3-cases
#19
S G S Datta, Ritu Mehta, Shrikant Macha, Sanjog Tripathi
No abstract text is available yet for this article.
June 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28599004/extraparenchymal-neurocysticercosis-demographic-clinicoradiological-and-inflammatory-features
#20
Mariana Marcin Sierra, Mariana Arroyo, May Cadena Torres, Nancy Ramírez Cruz, Fernando García Hernández, Diana Taboada, Ángeles Galicia Martínez, Tzipe Govezensky, Edda Sciutto, Andrea Toledo, Agnès Fleury
BACKGROUND: Extraparenchymal neurocysticercosis (ExPNCC), an infection caused by Taenia solium cysticerci that mainly occurs in the ventricular compartment (Ve) or the basal subarachnoid space (SAb), is more severe but less frequent and much less studied than parenchymal neurocysticercosis (ParNCC). Demographic, clinical, radiological, and lumbar cerebrospinal fluid features of patients affected by ExPNCC are herein described and compared with those of ParNCC patients. METHODOLOGY AND PRINCIPAL FINDINGS: 429 patients with a confirmed diagnosis of neurocysticercosis, attending the Instituto Nacional de Neurología y Neurocirugía, a tertiary reference center in Mexico City, from 2000 through 2014, were included...
June 2017: PLoS Neglected Tropical Diseases
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