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https://www.readbyqxmd.com/read/29908446/predicting-aged-pork-quality-using-a-portable-raman-device
#1
C C Santos, J Zhao, X Dong, S M Lonergan, E Huff-Lonergan, A Outhouse, K B Carlson, K J Prusa, C A Fedler, C Yu, S D Shackelford, D A King, T L Wheeler
The utility of Raman spectroscopic signatures of fresh pork loin (1 d & 15 d postmortem) in predicting fresh pork tenderness and slice shear force (SSF) was determined. Partial least square models showed that sensory tenderness and SSF are weakly correlated (R2  = 0.2). Raman spectral data were collected in 6 s using a portable Raman spectrometer (RS). A PLS regression model was developed to predict quantitatively the tenderness scores and SSF values from Raman spectral data, with very limited success...
May 29, 2018: Meat Science
https://www.readbyqxmd.com/read/29908227/hypogastric-preservation-using-retrograde-endovascular-bypass
#2
Mathew Wooster, Paul Armstrong, Martin Back
OBJECTIVE: Maintenance of pelvic circulation has been connected to reduced risks of ischemic colitis, buttock claudication, erectile dysfunction, and spinal cord ischemia during the treatment of extensive aorto-iliac aneurysmal disease. We evaluate the mid to late follow up of a cohort of patients treated using one preservation technique, the endovascular external (EIA) to internal (IIA) iliac artery bypass. METHODS: All patients undergoing elective retrograde EIA-IIA endovascular bypass at a single institution were retrospectively reviewed over a ten-year period from 2006-2016...
June 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29907913/total-hip-arthroplasty-in-osteonecrosis-secondary-to-sickle-cell-disease
#3
Mohamed Zubair Farook, Moji Awogbade, Karthik Somasundaram, Ines L H Reichert, Patrick L S Li
BACKGROUND: Sickle cell disease (SCD) is a multisystem disease, and the predominant articular manifestation is osteonecrosis (ON). Total hip arthroplasty (THA) is technically challenging, and the complication rates are high. In this retrospective study, we have analysed the outcome of THA in a cohort of patients with SCD at our institution. MATERIALS AND METHODS: We identified 34 THAs between 1999 and 2016 in 30 patients (mean age 37 years) from our SCD database...
June 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29907446/salvaging-the-dehisced-glans-penis
#4
C M White, M K Hanna
OBJECTIVE: The glans penis may show a deep groove (surgically favorable), or may appear flat with an absent sulcus (unfavorable). Glans dehiscence following hypospadias repair, especially after multiple surgeries, frequently results in a scarred, obliterated, or absent urethral plate. The glans penis appears to be flat and grooveless. This study reported on the outcome of a two-stage salvage repair for glans dehiscence in 49 consecutive patients. MATERIALS AND METHODS: Retrospective chart review was performed for all patients who underwent repair for glans dehiscence following hypospadias repair...
May 30, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29907418/long-term-experience-with-a-mandatory-clinical-decision-rule-and-mandatory-d-dimer-in-the-evaluation-of-suspected-pulmonary-embolism
#5
Guy W Soo Hoo, Emily Tsai, Sondra Vazirani, Zhaoping Li, Bruce M Barack, Carol C Wu
PURPOSE: This study evaluated the long-term effectiveness of mandatory assignment of both a clinical decision rule (CDR) and highly sensitive d-dimer in the evaluation of patients with suspected pulmonary embolism (PE). MATERIALS AND METHODS: Institutional guidelines with a CDR and highly sensitive d-dimer were embedded in an order entry menu with mandatory assignment of key components before ordering a CT pulmonary angiogram (CTPA). Data were retrospectively extracted from the electronic health record...
June 12, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29907323/taking-the-measure-of-the-profession-physician-associations-in-the-measurement-age
#6
REVIEW
Baruch Levi, Amos Zehavi, David Chinitz
Systematic measurement of healthcare services enables evaluation of health professionals' quality of work. Whereas policy makers find measurement a useful mechanism for quality improvement, a public choice perspective implies that physicians would resent such an initiative, which undermines their professional autonomy. In this article, we compare two healthcare systems of economically developed countries - Israel and the UK. Both systems share common features such as universal coverage, strong state intervention, and enthusiasm for New Public Management...
June 8, 2018: Health Policy
https://www.readbyqxmd.com/read/29907244/e-health-for-active-ageing-a-systematic-review
#7
REVIEW
Timothy David Robbins, Sarah N Lim Choi Keung, Theodoros N Arvanitis
Enabling successful active ageing is an international priority to meet the challenges of increasing life expectancy. Digital strategies, such as telemedicine and e-health, offer the potential to deliver active ageing in a cost-effective manner at scale. This article aims to establish the extent to which the research literature considers e-health-based and telemedicine-based active ageing interventions. A systematic review was conducted according to PRISMA standards. Independently, two authors searched the Cochrane, EMBASE & CINAHL databases, with subsequent independent extraction and semi-quantitative analysis...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907134/clinical-outcome-and-physical-activity-measured-with-stepwatch-3%C3%A2-activity-monitor-after-minimally-invasive-total-hip-arthroplasty
#8
Steffen Höll, Andreas Blum, Georg Gosheger, Ralf Dieckmann, Corinna Winter, Dieter Rosenbaum
BACKGROUND: Subjective data and physical examinations of patients after total hip arthroplasty are used to assess the outcome. But regarding the physical activity, no objective data can be delivered by existing scores. The level of activity can be measured objectively by counting gait cycles. The aim of this study was to measure activity levels of patients before and after total hip arthroplasty (THA). METHODS: Forty-six patients were included in this prospective study...
June 15, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29906692/rejection-sensitivity-and-psychopathology-symptoms-in-early-adolescence-the-moderating-role-of-personality-organization
#9
Andrea Fontana, Chiara De Panfilis, Erica Casini, Emanuele Preti, Juliette Richetin, Massimo Ammaniti
INTRODUCTION: Emerging personality organization may play an important role in the psychological adjustment of early adolescents, but research in this area is still limited. The current study evaluated if personality organization moderates the association between rejection sensitivity and adverse psychological outcomes in early adolescence. METHODS: Three-hundred eighty-six early adolescents (age range 13-15 years; 51% Female) attending junior high schools in Italy completed the semi-structured Interview of Personality Organization Processes in Adolescence (IPOP-A), the Children's Rejection Sensitivity Questionnaire (CRSQ), and the Youth Self Report/11-18 (YSR)...
June 12, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29906669/generation-of-gene-corrected-ipsc-line-from-parkinson-s-disease-patient-ipsc-line-with-alpha-snca-a53t-mutation
#10
Seo-Young Lee, SangKyun Jeong, Janghwan Kim, Sun-Ku Chung
Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. PD can result from a mutation of alpha-synuclein (α-SNCA), such as α-SNCA A53T. Using episomal vectors, induced pluripotent stem cells (iPSCs) were generated from skin fibroblasts with the α-SNCA A53T mutation. A huge bacterial artificial chromosome (BAC) harboring the normal α-SNCA gene successfully corrected the α-SNCA A53T-mutant iPSCs. Melting curve analysis for allelic composition indicated that the BAC DNA was precisely targeted to the α-SNCA A53T mutation allele, without random integration...
June 9, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29906495/hiv-infection-across-aging-synergistic-effects-on-intrinsic-functional-connectivity-of-the-brain
#11
Anna R Egbert, Bharat Biswal, Keerthana Karunakaran, Agnieszka Pluta, Tomasz Wolak, Stephen Rao, Robert Bornstein, Bogna Szymańska, Andrzej Horban, Ewa Firląg-Burkacka, Marta Sobańska, Natalia Gawron, Przemysław Bieńkowski, Halina Sienkiewicz-Jarosz, Anna Ścińska-Bieńkowska, Emilia Łojek
The objective of the study was to examine additive and synergistic effects of age and HIV infection on resting state (RS) intra- and inter-network functional connectivity (FC) of the brain. We also aimed to assess relationships with neurocognition and determine clinical-, treatment-, and health-related factors moderating intrinsic brain activity in aging HIV-positive (HIV+) individuals. The current report presents data on 54 HIV+ individuals (age M = 41, SD = 12 years) stabilized on cART and 54 socio-demographically matched healthy (HIV-) comparators (age M = 43, SD = 12 years), with cohort education mean of 16 years (SD = 12)...
June 12, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29906287/a-combination-of-quantitative-and-qualitative-methods-in-investigating-risk-factors-for-lost-to-follow-up-for-tuberculosis-treatment-in-japan-are-physicians-and-nurses-at-a-particular-risk
#12
Lisa Kawatsu, Kazuhiro Uchimura, Akihiro Ohkado, Seiya Kato
BACKGROUND: The treatment success rate of pulmonary tuberculosis (PTB) patients aged 64 years and below in Japan, a tuberculosis (TB) middle-burden country with a notification of 13.9 per 100,000 populations in 2016, has been fluctuating around 70% for some years. In order to improve treatment outcome, it is critical to address those lost to follow-up (LTFU). The objective of the study therefore was to describe the characteristics of, and analyze the risk factors for those LTFU among pulmonary TB patients aged between 15 and 64, and discuss policy implications...
2018: PloS One
https://www.readbyqxmd.com/read/29905827/predictors-of-residual-tricuspid-regurgitation-after-percutaneous-closure-of-atrial-septal-defect
#13
Martina Nassif, Frank van der Kley, Mohammad Abdelghani, Deborah N Kalkman, Rianne H A C M de Bruin-Bon, Berto J Bouma, Martin J Schalij, David R Koolbergen, Jan G P Tijssen, Barbara J M Mulder, Robbert J de Winter
Aims: Functional tricuspid regurgitation (TR) associated with atrial septal defects (ASDs) is frequently present due to right-sided volume-overload. Tricuspid valve (TV) repair is often considered in candidates for surgical ASD closure, and percutaneous TV repair is currently under clinical investigation. In this study, we develop a prediction model to identify patients with residual moderate/severe TR after percutaneous ASD closure. Methods and results: In this observational study, 172 adult patients (26% male, age 49 ± 17 years) with successful percutaneous ASD closure had pre- and post-procedural echocardiography...
June 13, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29905793/yeast-as-a-model-to-study-protein-misfolding-in-aged-cells
#14
Sonja E Di Gregorio, Martin L Duennwald
Yeast models of neurodegenerative diseases associated with protein misfolding and protein aggregation have given unique insights into the underlying genetic and cellular pathomechanisms. These yeast models recapitulate central aspects of protein misfolding and the ensuing toxicity, such as interference with cellular protein quality control, concentration-dependent formation of insoluble, often amyloid-like aggregates and the associated toxicity. Advanced age is undoubtedly the highest and most common risk factor for most neurodegenerative diseases...
September 1, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29905792/yeast-as-a-tool-to-identify-anti-aging-compounds
#15
Andreas Zimmermann, Sebastian Hofer, Tobias Pendl, Katharina Kainz, Frank Madeo, Didac Carmona-Gutierrez
In the search for interventions against aging and age-related diseases, biological screening platforms are indispensable tools to identify anti-aging compounds among large substance libraries. The budding yeast, Saccharomyces cerevisiae, has emerged as a powerful chemical and genetic screening platform, as it combines a rapid workflow with experimental amenability and the availability of a wide range of genetic mutant libraries. Given the amount of conserved genes and aging mechanisms between yeast and human, testing candidate anti-aging substances in yeast gene-deletion or overexpression collections, or de novo derived mutants, has proven highly successful in finding potential molecular targets...
September 1, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29905578/translational-models-of-infection-prevention-and-control-lessons-from-studying-high-risk-aging-populations
#16
Lona Mody
PURPOSE OF REVIEW: The present review describes our research experiences and efforts in advancing the field of infection prevention and control in nursing facilities including postacute and long-term care settings. RECENT FINDINGS: There are over two million infections in postacute and long-term care settings each year in the United States and $4 billion in associated costs. To define a target group most amenable to infection prevention and control interventions, we sought to quantify the relation between indwelling device use and microbial colonization in nursing facility patients...
June 13, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29905379/very-poor-long-term-survival-in-past-and-more-recent-studies-for-relapsed-aml-patients-the-ecog-acrin-experience
#17
Chezi Ganzel, Zhuoxin Sun, Larry D Cripe, Hugo F Fernandez, Dan Douer, Jacob M Rowe, Elisabeth M Paietta, Rhett Ketterling, Michael J O'Connell, Peter H Wiernik, John M Bennett, Mark R Litzow, Selina M Luger, Hillard M Lazarus, Martin S Tallman
This study examines the long-term OS of relapsed AML patients who were enrolled to 9 successive ECOG-ACRIN trials for newly diagnosed AML, during 1984-2008. The objectives were to examine whether there is a trend of improvement in the survival of relapsed AML patients in the more recent studies and to search for prognostic factors that are associated with long-term OS after relapse. A total of 3,012 patients were enrolled, 1,779(59.1%) achieved CR1 and of these, 58.9% relapsed. The median follow-up was 9.7 years...
June 15, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29905049/-application-of-combined-transverse-upper-gracilis-flap-and-adductor-magnus-perforator-flap-in-breast-reconstruction
#18
Dajiang Song, Zan Li, Xiao Zhou, Yixin Zhang, Xiaowei Peng, Bo Zhou, Chunliu Lü, Wen Peng, Huangxing Mao
Objective: To explore the clinical application of combined transverse upper gracilis flap and adductor magnus perforator flap in breast reconstruction of breast cancer patients after mastectomy. Methods: Between August 2016 and February 2017, the combined transverse upper gracilis flap and adductor magnus perforator flap was used in 12 cases of breast cancer patients who received modified radical surgery for breast reconstruction. All patients were females with the age of 32 to 59 years (mean, 41...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905047/-treatment-of-gartland-type-%C3%A2-and-%C3%A2-supracondylar-fracture-of-humerus-in-children
#19
Qing Zhou, Qingquan Kong, Bo Gao
Objective: To analyze the treatment of Gartland type Ⅱ and Ⅲ supracondylar fracture of the humerus in children. Methods: Between January 2015 and January 2017, 45 cases of Gartland type Ⅱ and Ⅲ supracondylar fracture of the humerus were treated. There were 28 boys and 17 girls with an age of 1-13 years (mean, 5.7 years). The causes of injury included sports injury in 43 cases and falling from height in 2 cases. Fractures were classified as type Ⅱ in 12 cases and type Ⅲ in 33 cases according to Gartland classification...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905045/-clinical-research-of-debridement-with-prosthesis-retention-for-periprosthetic-joint-infection-after-arthroplasty
#20
Xinggui Song, Xin Li, Junlei Song, Chi Xu, Rui Li, Heng Li, Jiying Chen
Objective: To investigate the mid-term effectiveness of debridement with prosthesis retention for periprosthetic joint infection (PJI) after total hip arthroplasty (THA) and total knee arthroplasty (TKA), and analyze the influence factors that affected the effectiveness. Methods: A clinical data of 45 cases with PJI after THA (16 cases) and TKA (29 cases) that were treated with debridement with prosthesis retention between January 2011 and January 2015 were collected and analyzed...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
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