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https://www.readbyqxmd.com/read/28706091/predict-cp-study-protocol-of-implementation-of-comprehensive-surveillance-to-predict-outcomes-for-school-aged-children-with-cerebral-palsy
#1
Roslyn N Boyd, Peter Sw Davies, Jenny Ziviani, Stewart Trost, Lee Barber, Robert Ware, Stephen Rose, Koa Whittingham, Leanne Sakzewski, Kristie Bell, Christopher Carty, Steven Obst, Katherine Benfer, Sarah Reedman, Priya Edwards, Megan Kentish, Lisa Copeland, Kelly Weir, Camilla Davenport, Denise Brooks, Alan Coulthard, Rebecca Pelekanos, Andrea Guzzetta, Simona Fiori, Meredith Wynter, Christine Finn, Andrea Burgess, Kym Morris, John Walsh, Owen Lloyd, Jennifer A Whitty, Paul A Scuffham
OBJECTIVES: Cerebral palsy (CP) remains the world's most common childhood physical disability with total annual costs of care and lost well-being of $A3.87b. The PREDICT-CP (NHMRC 1077257 Partnership Project: Comprehensive surveillance to PREDICT outcomes for school age children with CP) study will investigate the influence of brain structure, body composition, dietary intake, oropharyngeal function, habitual physical activity, musculoskeletal development (hip status, bone health) and muscle performance on motor attainment, cognition, executive function, communication, participation, quality of life and related health resource use costs...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28690540/the-role-of-microglia-in-prion-diseases-a-paradigm-of-functional-diversity
#2
REVIEW
Juliane Obst, Emilie Simon, Renzo Mancuso, Diego Gomez-Nicola
Inflammation is a major component of neurodegenerative diseases. Microglia are the innate immune cells in the central nervous system (CNS). In the healthy brain, microglia contribute to tissue homeostasis and regulation of synaptic plasticity. Under disease conditions, they play a key role in the development and maintenance of the neuroinflammatory response, by showing enhanced proliferation and activation. Prion diseases are progressive chronic neurodegenerative disorders associated with the accumulation of the scrapie prion protein PrP(Sc), a misfolded conformer of the cellular prion protein PrP(C)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28685156/road-map-fluoroscopy-successfully-guides-endoscopic-interventions-in-the-esophagus
#3
Jochen Weigt, Wilfried Obst, Arne Kandulski, Maciej Pech, Ali Canbay, Peter Malfertheiner
BACKGROUND AND STUDY AIMS : Road Map (RM) fluoroscopy is a radiological technique that enables visualization of anatomic structures using image subtraction at peak opacification. RM fluoroscopy has never previously been evaluated for use in endoscopy. The aim of this study was to evaluate the usefulness of RM in guiding endoscopic intervention in the esophagus. PATIENTS AND METHODS : This was a monocentric observational trial of consecutive patients with esophageal strictures in a university hospital...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28620014/the-tendinopathic-achilles-tendon-does-not-remain-iso-volumetric-upon-repeated-loading-insights-from-3d-ultrasound
#4
Leila Nuri, Steven J Obst, Richard Newsham-West, Rod S Barrett
Mid-portion Achilles tendinopathy (MAT) alters the normal three-dimensional (3D) morphology of the Achilles tendon (AT) at rest and under a single tensile load. However, how MAT changes the 3D morphology of AT during repeated loading remains unclear. This study compared the AT longitudinal, transverse and volume strains during repeated loading in MAT with those of the contralateral tendon in people with unilateral MAT. Ten adults with unilateral MAT performed 10 successive 25 second submaximal (50%) voluntary isometric plantarflexion contractions with both legs...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28582546/the-contribution-of-homology-arms-to-nuclease-assisted-genome-engineering
#5
Oliver Baker, Sarah Tsurkan, Jun Fu, Barbara Klink, Andreas Rump, Mandy Obst, Andrea Kranz, Evelin Schröck, Konstantinos Anastassiadis, A Francis Stewart
Designer nucleases like CRISPR/Cas9 enable fluent site-directed damage or small mutations in many genomes. Strategies for their use to achieve more complex tasks like regional exchanges for gene humanization or the establishment of conditional alleles are still emerging. To optimize Cas9-assisted targeting, we measured the relationship between targeting frequency and homology length in targeting constructs using a hypoxanthine-guanine phosphoribosyl-transferase assay in mouse embryonic stem cells. Targeting frequency with supercoiled plasmids improved steeply up to 2 kb total homology and continued to increase with even longer homology arms, thereby implying that Cas9-assisted targeting efficiencies can be improved using homology arms of 1 kb or greater...
June 5, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28548516/relativistic-electron-streaming-instabilities-modulate-proton-beams-accelerated-in-laser-plasma-interactions
#6
S Göde, C Rödel, K Zeil, R Mishra, M Gauthier, F-E Brack, T Kluge, M J MacDonald, J Metzkes, L Obst, M Rehwald, C Ruyer, H-P Schlenvoigt, W Schumaker, P Sommer, T E Cowan, U Schramm, S Glenzer, F Fiuza
We report experimental evidence that multi-MeV protons accelerated in relativistic laser-plasma interactions are modulated by strong filamentary electromagnetic fields. Modulations are observed when a preplasma is developed on the rear side of a μm-scale solid-density hydrogen target. Under such conditions, electromagnetic fields are amplified by the relativistic electron Weibel instability and are maximized at the critical density region of the target. The analysis of the spatial profile of the protons indicates the generation of B>10  MG and E>0...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28511014/protein-corona-formation-on-colloidal-polymeric-nanoparticles-and-polymeric-nanogels-impact-on-cellular-uptake-toxicity-immunogenicity-and-drug-release-properties
#7
Katja Obst, Guy Yealland, Benjamin Balzus, Enrico Miceli, Mathias Dimde, Christoph Weise, Murat Eravci, Roland Bodmeier, Rainer Haag, Marcelo Calderón, Nada Charbaji, Sarah Hedtrich
The adsorption of biomolecules to the surface of nanoparticles (NPs) following administration into biological environments is widely recognized. In particular, the "protein corona" is well understood in terms of formation kinetics and impact upon the biological interactions of NPs. Its presence is an essential consideration in the design of therapeutic NPs. In the present study, the protein coronas of six polymeric nanoparticles of prospective therapeutic use were investigated. These included three colloidal NPs-soft core-multishell (CMS) NPs, plus solid cationic Eudragit RS (EGRS), and anionic ethyl cellulose (EC) nanoparticles-and three nanogels (NGs)-thermoresponsive dendritic-polyglycerol (dPG) nanogels (NGs) and two amino-functionalized dPG-NGs...
May 26, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28505685/-weaning-unit-of-the-university-medicine-greifswald-institutional-structure-and-weaning-results-from-prolonged-ventilation-over-10-years
#8
A Müller-Heinrich, C Warnke, A Heine, T Bollmann, M Boesche, C Schäper, B Stubbe, S Friesecke, S B Felix, S Gläser, A Obst, R Ewert
The increasing importance of intensive care medicine including mechanical ventilation has been accompanied by the demand of weaning opportunities for patients undergoing prolonged mechanical ventilation. Consequently, specialised clinical institutions, focusing on the weaning from mechanical ventilation, have been established since the 1980 s.The present article illustrates the structural development and results of such a specialised institution at the University Medicine Greifswald, using data of 616 patients collected within the past ten years (2006 - 2015)...
May 15, 2017: Pneumologie
https://www.readbyqxmd.com/read/28455336/insights-into-nitrate-reducing-fe-ii-oxidation-mechanisms-through-analysis-of-cell-mineral-associations-cell-encrustation-and-mineralogy-in-the-chemolithoautotrophic-enrichment-culture-ks
#9
M Nordhoff, C Tominski, M Halama, J M Byrne, M Obst, S Kleindienst, S Behrens, A Kappler
Most described nitrate-reducing Fe(II)-oxidizing bacteria (NRFeOB) are mixotrophic and depend on organic cosubstrates for growth. Encrustation of cells in Fe(III) minerals has been observed for mixotrophic NRFeOB but not for autotrophic phototrophic and microaerophilic Fe(II) oxidizers. So far, little is known about cell-mineral associations in the few existing autotrophic NRFeOB. Here, we investigate whether the designated autotrophic Fe(II)-oxidizing strain (closely related to Gallionella and Sideroxydans) or the heterotrophic nitrate reducers that are present in the autotrophic nitrate-reducing Fe(II)-oxidizing enrichment culture KS form mineral crusts during Fe(II) oxidation under autotrophic and mixotrophic conditions...
July 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28422617/hidden-devices-in-the-school-setting-what-the-nurse-needs-to-know-about-shunts
#10
Barbara Obst, Megan Roesler
The role of school nurse today not only includes making a thorough assessment of the child but also the knowledge and skill to understand hidden medical devices. As of 2011, there were approximately 14.6 million children in the United States living with special health care needs. Many of these children could have hidden medical devices. The Specialized Health Needs Interagency Collaboration (SHNIC) program at the Kennedy Krieger Institute received requests for in-person training regarding ventriculoperitoneal (VP) shunts...
May 2017: NASN School Nurse
https://www.readbyqxmd.com/read/28402123/iron-isotope-fractionation-during-fe-ii-oxidation-mediated-by-the-oxygen-producing-marine-cyanobacterium-synechococcus-pcc-7002
#11
E D Swanner, T Bayer, W Wu, L Hao, M Obst, A Sundman, J M Byrne, F M Michel, I C Kleinhanns, A Kappler, R Schoenberg
In this study, we couple iron isotope analysis to microscopic and mineralogical investigation of iron speciation during circumneutral Fe(II) oxidation and Fe(III) precipitation with photosynthetically produced oxygen. In the presence of the cyanobacterium Synechococcus PCC 7002, aqueous Fe(II) (Fe(II)aq) is oxidized and precipitated as amorphous Fe(III) oxyhydroxide minerals (iron precipitates, Feppt), with distinct isotopic fractionation (ε(56)Fe) values determined from fitting the δ(56)Fe(II)aq (1.79‰ and 2...
May 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28394214/does-online-social-connectedness-buffer-risk-of-depression-following-driving-cessation-an-analysis-of-older-drivers-and-ex-drivers
#12
Kristina G Challands, Philippe Lacherez, Patricia L Obst
This study investigates the role of online social connectedness as a buffer against depression in older adults who cease driving. A survey of 108 over-65 year olds (M = 73.7, SD = 7.37) was conducted. Measures included online and offline social connectedness; depression; online activities; and general health. The online activities in which older adults most frequently engaged were communicating with family and friends, reading the news, and banking. Face-to-face social connectedness was by far the strongest predictor of depression...
April 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28359571/achilles-tendon-stress-is-more-sensitive-to-subject-specific-geometry-than-subject-specific-material-properties-a-finite-element-analysis
#13
Wencke Hansen, Vickie B Shim, Steven Obst, David G Lloyd, Richard Newsham-West, Rod S Barrett
This study used subject-specific measures of three-dimensional (3D) free Achilles tendon geometry in conjunction with a finite element method to investigate the effect of variation in subject-specific geometry and subject-specific material properties on tendon stress during submaximal isometric loading. Achilles tendons of eight participants (Aged 25-35years) were scanned with freehand 3D ultrasound at rest and during a 70% maximum voluntary isometric contraction. Ultrasound images were segmented, volume rendered and transformed into subject-specific 3D finite element meshes...
May 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28285516/investigation-on-key-molecules-of-huanglongbing-hlb-induced-orange-juice-off-flavor
#14
Johannes Kiefl, Birgit Kohlenberg, Anja Hartmann, Katja Obst, Susanne Paetz, Gerhard Krammer, Stephan Trautzsch
Orange fruits from huanglongbing (HLB)-infected trees do not fully mature and show a severe off-flavor described as bitter-harsh, metallic, and less juicy and fruity. The investigation of juice from HLB-infected (HLBOJ) and healthy control oranges (COJ) by gas chromatography-mass spectrometry showed higher concentrations of fruity esters, such as ethyl butyrate and ethyl 2-methylbutyrate, and soapy-waxy alkanals, such as octanal and decanal, in the COJ, whereas the HLBOJ showed higher concentrations of green aldehydes such as hexanal and degradation compounds of limonene and linalool such as α-terpineol...
March 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28261596/the-freedom-of-choice
#15
COMMENT
Jochen Weigt, Wilfried Obst, Peter Malfertheiner
No abstract text is available yet for this article.
February 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28259193/two-and-three-dimensional-mid-infrared-chemical-imaging
#16
Fabio Zobi, Martin Obst
This article describes the state-of-the-art in 2D and 3D tomographic mid-IR imaging and its current and potential applications in the imaging of material and biological systems with a focus on cells and tissues. 2D FTIR microscopy is first presented in terms of the basic experimental configurations of the technique, optics, data and image acquisition. This first section provides a basis for the ensuing discussion on 3D FTIR spectro-microtomography. In the second part, examples of 2D and 3D chemical imaging are given with a focus on the use of molecular chemical probes and probe-free applications, respectively...
February 22, 2017: Chimia
https://www.readbyqxmd.com/read/28252957/a-modular-toolkit-for-generating-pichia-pastoris-secretion-libraries
#17
Ulrike Obst, Timothy K Lu, Volker Sieber
Yeasts are powerful eukaryotic hosts for the production of recombinant proteins due to their rapid growth to high cell densities and ease of genetic modification. For large-scale industrial production, secretion of a protein offers the advantage of simple and efficient downstream purification that avoids costly cell rupture, denaturation and refolding. The methylotrophic yeast Pichia pastoris (Komagataella phaffi) is a well-established expression host that has the ability to perform post-translational modifications and is generally regarded as safe (GRAS)...
March 15, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28187221/smoking-beliefs-among-chinese-secondary-school-students-a-theory-based-qualitative-study
#18
Xiang Zhao, Katherine M White, Ross McD Young, Patricia L Obst
No abstract text is available yet for this article.
January 25, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28159791/microaerophilic-fe-ii-oxidizing-zetaproteobacteria-isolated-from-low-fe-marine-coastal-sediments-physiology-and-composition-of-their-twisted-stalks
#19
K Laufer, M Nordhoff, M Halama, R E Martinez, M Obst, M Nowak, H Stryhanyuk, H H Richnow, A Kappler
Microaerophilic Fe(II) oxidizers are commonly found in habitats containing elevated Fe(II) and low O2 concentrations and often produce characteristic Fe mineral structures, so-called twisted stalks or tubular sheaths. Isolates originating from freshwater habitats are all members of the Betaproteobacteria, while isolates from marine habitats belong almost exclusively to the Zetaproteobacteria So far, only a few isolates of marine microaerophilic Fe(II) oxidizers have been described, all of which are obligate microaerophilic Fe(II) oxidizers and have been thought to be restricted to Fe-rich systems...
April 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28147634/high-resolution-quasi-monochromatic-x-ray-imaging-using-a-fresnel-phase-zone-plate-and-a-multilayer-mirror
#20
A Do, Ph Troussel, S D Baton, V Dervieux, D Gontier, L Lecherbourg, B Loupias, L Obst, F Pérez, P Renaudin, Ch Reverdin, C Rubbelynck, Ph Stemmler, G Soullié
High-resolution, high-sensitivity X-ray imaging is a real challenge in laser plasma diagnostic to attain reliable data in high-energy density plasma experiments. In this context, ultra-high-intensity lasers generate hot and dense plasma but only in a small volume. An experiment has been performed at the LULI2000 laser facility to diagnose such plasma conditions from thermal spectroscopic data. To image the emission zone plasma's Al Heβ, a Fresnel-lens-based X-ray imager has been developed. It features a 846 μm-diameter Fresnel Phase Zone Plate (FPZP) and a Pd/B4C multilayer mirror (thickness d = 5...
January 2017: Review of Scientific Instruments
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